Updated on 2026/03/10

写真a

 
HASHIMOTO Akiyoshi
 
Organization
School of Medicine Department of Health Care Administration and Management Professor
Title
Professor
External link

Degree

  • MD

Research Interests

  • 循環器内科学 心臓核医学

Research Areas

  • Natural Science / Biophysics, chemical physics and soft matter physics

Professional Memberships

Papers

  • Determinant of functional independence in older patients with heart failure: physical function vs. muscle mass. International journal

    Suguru Honma, Satoshi Katano, Toshiyuki Yano, Ryohei Nagaoka, Aki Habaguchi, Ryo Numazawa, Katsuhiko Ohori, Hidemichi Kouzu, Masaki Katayose, Nobuhiro Yoshioka, Masato Furuhashi, Akiyoshi Hashimoto

    Archives of gerontology and geriatrics   137   105933 - 105933   2025.10

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    Language：English   Publishing type：Research paper (scientific journal)  

    AIM: While sarcopenia affects functional independence in older patients with heart failure (HF), the differential impact of its components-including muscle mass (MM), muscle strength (MS), and physical function (PF)-remain underexplored. We investigated these components' independent and synergistic associations with functional independence in older patients with HF, including sex-specific differences. METHODS: We studied 587 older patients with HF (299 women; mean age, 79±7 years). MM, MS, and PF were assessed using dual-energy X-ray absorptiometry, handgrip strength, and physical performance tests (gait speed, five-times sit-to-stand test [FTSS], short physical performance battery [SPPB]), respectively. Cutoffs for each component followed the Asian Working Group for Sarcopenia 2019 criteria. Functional independence was assessed using the Barthel Index (BI). RESULTS: Sarcopenia was associated with lower BI scores. Poor PF independently predicted reduced BI scores (slow gait speed: 8.4 points; prolonged FTSS: 10.9 points; low SPPB: 14.8 points; all p < 0.001), whereas low MM and weak MS did not. Low MM amplified the negative impact of poor PF on BI scores consistently across sexes. Machine-learning analysis revealed MM status-specific predictors of PF: clinical factors (female sex, HF symptoms) and comorbidities predicted poor PF in patients with normal MM; renin-angiotensin system inhibition, and cardiomyopathy were associated with preserved PF in patients with low MM. CONCLUSIONS: In older patients with HF, sarcopenia is closely and negatively associated with BI score primarily through poor PF; MM potentially modifies this relationship independent of sex. MM status-specific factors associated with PF suggest the importance of phenotype-specific approaches in facilitating functional independence.

    DOI： 10.1016/j.archger.2025.105933

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  • Prognostic implication of sarcopenia diagnosed by updated Asian Working Group for Sarcopenia criteria in older patients with heart failure: Utility and limitation. International journal

    Satoshi Katano, Kotaro Yamano, Toshiyuki Yano, Ryo Numazawa, Ryohei Nagaoka, Suguru Honma, Yusuke Fujisawa, Yasuhiro Miki, Yuhei Takamura, Hayato Kunihara, Hiroya Fujisaki, Hidemichi Kouzu, Katsuhiko Ohori, Masaki Katayose, Akiyoshi Hashimoto, Masato Furuhashi

    The journal of nutrition, health & aging   29 ( 1 )   100434 - 100434   2025.1

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    OBJECTIVES: The utility of the updated Asian Working Group for Sarcopenia (AWGS) criteria in diagnosing sarcopenia in older patients with heart failure (HF) remains unclear. OBJECTIVE: To analyze the prevalence and prognostic impact of sarcopenia diagnosed by the updated AWGS criteria in older patients with HF. DESIGN: Ambispective cohort study. SETTING & SUBJECTS: 534 older patients with HF from a university hospital in Japan. MEASUREMENTS: Sarcopenia was assessed using different versions of the AWGS criteria: AWGS 2014, AWGS 2019H (muscle mass relative to height squared), and AWGS 2019B (muscle mass relative to BMI). The primary endpoint was all-cause mortality at three years post-discharge. RESULTS: Of 534 patients, 42%, 57%, and 44% were diagnosed with sarcopenia according to AWGS 2014, AWGS 2019H, AWGS 2019B, respectively. Among patients without AWGS 2014-defined sarcopenia, 23% were reclassified as having sarcopenia by AWGS 2019H criteria. Forty-four percent of sarcopenic patients diagnosed by AWGS 2019H were re-classified as non-sarcopenic by AWGS 2019B, with lower fat mass and poorer nutritional status. After the multivariate Cox proportional hazard analyses, an association between all-cause death and sarcopenia remained significant for AWGS 2014 (hazard ratio [HR], 1.55; 95% confidence interval [CI], 1.01-2.37) and AWGS 2019H (HR, 1.65; 95% CI, 1.05-2.59), but not for AWGS 2019B (HR, 0.99; 95% CI, 0.64-1.51). CONCLUSION: The updated AWGS 2019H criteria detected more sarcopenic patients with HF while maintaining favorable predictive ability. The use of BMI-adjusted muscle mass reclassified underweight and malnourished patients as non-sarcopenic, limiting its impact on the mortality prediction in older patients with HF.

    DOI： 10.1016/j.jnha.2024.100434

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  • VA-ECMOを要したCCB-responder PHの一例

    戸田 皓二郎, 小山 雅之, 大久保 武志, 大友 俊作, 西川 諒, 村上 直人, 永野 伸卓, 國分 宣明, 橋本 暁佳, 古橋 眞人

    日本肺高血圧・肺循環学会学術集会抄録集   9回   220 - 220   2024.8

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    Language：Japanese   Publisher：日本肺高血圧・肺循環学会  

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  • Independent Link Between Use of Mineralocorticoid Receptor Antagonists and Muscle Wasting in Heart Failure Patients Not Receiving Renin-Angiotensin System Inhibitors.

    Ryo Numazawa, Satoshi Katano, Toshiyuki Yano, Ryohei Nagaoka, Katsuhiko Ohori, Hidemichi Kouzu, Suguru Honma, Yusuke Fujisawa, Kotaro Yamano, Arata Osanami, Masayuki Koyama, Akiyoshi Hashimoto, Masato Furuhashi

    Circulation journal : official journal of the Japanese Circulation Society   88 ( 1 )   10 - 19   2023.12

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    BACKGROUND: The renin-angiotensin system (RAS) activation is a proposed mechanism of muscle wasting (MW i.e., reduction in muscle mass). Although we reported that RAS inhibitors (RASIs) were associated with lower prevalence of MW in heart failure (HF) patients, the relationship between mineralocorticoid receptor (MR) signaling and MW has not been analyzed. METHODS AND RESULTS: We analyzed data from 320 consecutive Japanese HF patients who underwent dual-energy X-ray absorptiometry scanning for assessment of appendicular skeletal muscle mass index (ASMI). In multiple linear regression analyses, plasma renin activity (PRA) was negatively correlated with ASMI in patients not receiving RASIs, indicating an untoward role of the RAS in MW. Results of analysis of covariance in which risk factors of MW served as covariates showed that use of MR antagonists (MRAs) was associated with lower ASMI and higher PRA in the non-RASIs group. The close relationship between use of MRAs and lower ASMI or higher PRA in the non-RASIs group was confirmed in analyses in which the differences in baseline characteristics between users and non-users of MRAs were minimized by using an inverse probability of treatment weighting. CONCLUSIONS: Increased PRA by MR inhibition without concurrent RAS inhibition, possibly contributing to upregulation of angiotensin II signaling, may be associated with reduction in muscle mass.

    DOI： 10.1253/circj.CJ-23-0567

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  • Loss of perceived social role, an index of social frailty, is an independent predictor of future adverse events in hospitalized patients with heart failure

    Ayako Watanabe, Satoshi Katano, Toshiyuki Yano, Ryohei Nagaoka, Ryo Numazawa, Suguru Honma, Kotaro Yamano, Yusuke Fujisawa, Katsuhiko Ohori, Hidemichi Kouzu, Tomoyuki Ishigo, Masaki Katayose, Akiyoshi Hashimoto, Masato Furuhashi

    Frontiers in Cardiovascular Medicine   9   2022.12

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    Publishing type：Research paper (scientific journal)   Publisher：Frontiers Media SA  

    Aims

    Although the impact of physical frailty on prognosis and the effect of cardiac rehabilitation in HF patients has been well established, data for the prognostic impact of social frailty (SF) in HF patients are limited. In addition, the relative importance of each SF domain in clinical outcomes remains unclear. We aimed to get a new insight into the associations of SF with clinical outcomes in elderly hospitalized HF patients.

    Methods

    A single-center, retrospective cohort study was conducted using data from 310 in-hospital HF patients aged ≥ 65 years (mean age of 78 ± 8 years; 49% women). Makizako’s five questions, a self-reported questionnaire, were used to define SF. The primary outcome was composite events defined by all-cause death and cardiovascular events.

    Results

    Of the 310 elderly HF patients, 188 patients (61%) had SF. Seventy-five patients (24%) had composite events during a mean follow-up period of 1.93 ± 0.91 years. Kaplan-Meier curves showed that patients with SF had a significantly higher composite event rate than patients without SF. In multivariate Cox regression analyses, SF was independently associated with a higher composite event rate after adjusting for prognostic markers [adjusted hazard ratio (HR), 2.01; 95% confidence interval (CI), 1.07–3.78; p = 0.04]. Of the 5 questions for defining SF, an answer of yes to the question about not feeling helpful toward friends or family, which indicates loss of perceived social role, was an independent predictor of composite events (adjusted HR, 2.28; 95% CI, 1.36–3.82; p &amp;lt; 0.01). Inclusion of loss of perceived social role into the baseline prognostic model improved both the continuous net reclassification improvement (0.562; 95% CI, 0.298–0.827; p &amp;lt; 0.01) and integrated discrimination improvement (0.031; 95% CI, 0.006–0.056; p = 0.02).

    Conclusion

    Loss of perceived social role is associated with increased adverse event risk and provides additive prognostic information in elderly HF patients.

    DOI： 10.3389/fcvm.2022.1051570

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  • Anthropometric parameters‐derived estimation of muscle mass predicts all‐cause mortality in heart failure patients

    Satoshi Katano, Suguru Honma, Ryohei Nagaoka, Ryo Numazawa, Kotaro Yamano, Yusuke Fujisawa, Katsuhiko Ohori, Hidemichi Kouzu, Akiyoshi Hashimoto, Masaki Katayose, Toshiyuki Yano

    ESC Heart Failure   2022.9

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    Publishing type：Research paper (scientific journal)   Publisher：Wiley  

    Other Link： https://onlinelibrary.wiley.com/doi/full-xml/10.1002/ehf2.14121

    DOI： 10.1002/ehf2.14121

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  • Barthel Index Score Predicts Mortality in Elderly Heart Failure - A Goal of Comprehensive Cardiac Rehabilitation.

    Satoshi Katano, Toshiyuki Yano, Katsuhiko Ohori, Hidemichi Kouzu, Ryohei Nagaoka, Suguru Honma, Kanako Shimomura, Takuya Inoue, Yuhei Takamura, Tomoyuki Ishigo, Ayako Watanabe, Masayuki Koyama, Nobutaka Nagano, Takefumi Fujito, Ryo Nishikawa, Wataru Ohwada, Akiyoshi Hashimoto, Masaki Katayose, Sumio Ishiai, Tetsuji Miura

    Circulation journal : official journal of the Japanese Circulation Society   86 ( 1 )   70 - 78   2021.12

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    BACKGROUND: A strategy to predict mortality in elderly heart failure (HF) patients has not been established.Methods and Results:We retrospectively enrolled 413 HF patients aged ≥65 years (mean age 78 years) who had received comprehensive cardiac rehabilitation (CR) during hospitalization. Basic activities of daily life were assessed before discharge using the Barthel index (BI). Of 413 HF patients, 116 (28%) died during a median follow-up period of 1.90 years (interquartile range 1.20-3.23 years). An adjusted dose-dependent association analysis showed that the hazard ratio (HR) of mortality increased in an almost linear manner as the BI score decreased, and that a BI score of 85 corresponded to an HR of 1.0. Kaplan-Meier survival curves showed that the survival rate was lower for patients with a low BI (<85) than for those with a high BI (≥85; 65% vs. 74%, respectively; P=0.007). In multivariate Cox regression analyses, low BI was independently associated with higher mortality after adjusting for predictors, including B-type natriuretic peptide. Inclusion of the BI into the adjusted model improved the accuracy of the prediction of mortality. CONCLUSIONS: A BI score <85 at the time of discharge is associated with increased mortality independent of known prognostic markers, and achieving functional status with a BI score ≥85 by comprehensive CR during hospitalization may contribute to favorable outcomes in elderly HF patients.

    DOI： 10.1253/circj.CJ-21-0584

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  • Abrupt Onset of Cardiac Tamponade in Sarcoidosis.

    Toshiyuki Yano, Shin Hisahara, Nobutaka Nagano, Takahiro Noto, Toshifumi Ogawa, Ryo Nishikawa, Masayuki Koyama, Hidemichi Kouzu, Atsuko Muranaka, Akiyoshi Hashimoto, Shun Shimohama, Tetsuji Miura

    International heart journal   62 ( 5 )   1176 - 1181   2021.9

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    DOI： 10.1536/ihj.21-167

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  • Novel prediction equation for appendicular skeletal muscle mass estimation in patients with heart failure: Potential application in daily clinical practice. International journal

    Satoshi Katano, Toshiyuki Yano, Katsuhiko Ohori, Nobutaka Nagano, Suguru Honma, Kanako Shimomura, Tomoyuki Ishigo, Ayako Watanabe, Remi Honma, Takefumi Fujito, Masayuki Koyama, Hidemichi Kouzu, Akiyoshi Hashimoto, Masaki Katayose, Tetsuji Miura

    European journal of preventive cardiology   28 ( 9 )   e18-e21   2021.8

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    DOI： 10.1177/2047487320904236

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  • Energy intake during hospital stay predicts all-cause mortality after discharge independently of nutritional status in elderly heart failure patients. International journal

    Satoshi Katano, Toshiyuki Yano, Hidemichi Kouzu, Katsuhiko Ohori, Kanako Shimomura, Suguru Honma, Ryohei Nagaoka, Takuya Inoue, Yuhei Takamura, Tomoyuki Ishigo, Ayako Watanabe, Masayuki Koyama, Nobutaka Nagano, Takefumi Fujito, Ryo Nishikawa, Wataru Ohwada, Akiyoshi Hashimoto, Masaki Katayose, Tetsuji Miura

    Clinical research in cardiology : official journal of the German Cardiac Society   110 ( 8 )   1202 - 1220   2021.8

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    OBJECTIVE: Malnutrition is associated with an increased risk of mortality in heart failure (HF) patients. Here, we examined the hypothesis that assessment of energy intake in addition to nutritional status improves the stratification of mortality risk in elderly HF patients. METHODS: We retrospectively examined 419 HF patients aged ≥ 65 years (median 78 years, 49% female). Nutritional status was assessed by the Mini Nutritional Assessment Short Form (MNA-SF), and daily energy intake was calculated from intake during 3 consecutive days before discharge. RESULTS: During a median 1.52-year period (IQR 0.96-2.94 years), 110 patients (26%) died. Kaplan-Meier survival curves showed that patients with low tertile of daily energy intake had a higher mortality rate than did patients with high or middle tertile of daily energy intake. In multivariate Cox regression analyses, low daily energy intake was independently associated with higher mortality after adjustment for the model including age, sex, BNP, Charlson Comorbidity Index, history of HF hospitalization, and cachexia in addition to MNA-SF. Inclusion of both MNA-SF and energy intake into the adjustment model improved the accuracy of prediction of the mortality after discharge (continuous net reclassification improvement, 0.355, p = 0.003; integrated discrimination improvement, 0.029, p = 0.003). Results of a fully adjusted dose-dependent association analysis showed that risk of all-cause mortality was lowest among HF patients who consumed 31.5 kcal/kg/day of energy. CONCLUSIONS: Energy intake during hospital stay is an independent predictor of the mortality in elderly HF patients, and its assessment together with established predictors improves the mortality risk stratification.

    DOI： 10.1007/s00392-020-01774-y

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  • Relationship between Risk Factor Management and Lesion Distribution in Coronary Artery Stenosis: A Cross-sectional Analysis of BOREAS-CAG Registry Data(和訳中)

    高橋 遼, 國分 宣明, 小山 雅之, 岸上 直広, 中田 潤, 西川 諒, 村上 直人, 永野 伸卓, 丹野 雅也, 大西 浩文, 橋本 暁佳, 土橋 和文, 三浦 哲嗣

    日本循環器学会学術集会抄録集   85回   OJ06 - 3   2021.3

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  • High percent body fat mass predicts lower risk of cardiac events in patients with heart failure: an explanation of the obesity paradox. International journal

    Katsuhiko Ohori, Toshiyuki Yano, Satoshi Katano, Hidemichi Kouzu, Suguru Honma, Kanako Shimomura, Takuya Inoue, Yuhei Takamura, Ryohei Nagaoka, Masayuki Koyama, Nobutaka Nagano, Takefumi Fujito, Ryo Nishikawa, Tomoyuki Ishigo, Ayako Watanabe, Akiyoshi Hashimoto, Tetsuji Miura

    BMC geriatrics   21 ( 1 )   16 - 16   2021.1

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    BACKGROUND: Although high body mass index (BMI) is a risk factor of heart failure (HF), HF patients with a higher BMI had a lower mortality rate than that in HF patients with normal or lower BMI, a phenomenon that has been termed the "obesity paradox". However, the relationship between body composition, i.e., fat or muscle mass, and clinical outcome in HF remains unclear. METHODS: We retrospectively analyzed data for 198 consecutive HF patients (76 years of age; males, 49%). Patients who were admitted to our institute for diagnosis and management of HF and received a dual-energy X-ray absorptiometry scan were included regardless of left ventricular ejection fraction (LVEF) categories. Muscle wasting was defined as appendicular skeletal muscle mass index < 7.0 kg/m2 in males and < 5.4 kg/m2 in females. Increased percent body fat mass (increased FM) was defined as percent body fat > 25% in males and > 30% in females. RESULTS: The median age of the patients was 76 years (interquartile range [IQR], 67-82 years) and 49% of them were male. The median LVEF was 47% (IQR, 33-63%) and 33% of the patients had heart failure with reduced ejection fraction. Increased FM and muscle wasting were observed in 58 and 67% of the enrolled patients, respectively. During a 180-day follow-up period, 32 patients (16%) had cardiac events defined as cardiac death or readmission by worsening HF or arrhythmia. Kaplan-Meier survival curves showed that patients with increased FM had a lower cardiac event rate than did patients without increased FM (11.4% vs. 22.6%, p = 0.03). Kaplan-Meier curves of cardiac event rates did not differ between patients with and those without muscle wasting (16.5% vs. 15.4%, p = 0.93). In multivariate Cox regression analyses, increased FM was independently associated with lower cardiac event rates (hazard ratio: 0.45, 95% confidence interval: 0.22-0.93) after adjustment for age, sex, diabetes, muscle wasting, and renal function. CONCLUSIONS: High percent body fat mass is associated with lower risk of short-term cardiac events in HF patients.

    DOI： 10.1186/s12877-020-01950-9

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  • Distinct determinants of muscle wasting in nonobese heart failure patients with and without type 2 diabetes mellitus. International journal

    Toshiyuki Yano, Satoshi Katano, Hidemichi Kouzu, Ryohei Nagaoka, Takuya Inoue, Yuhei Takamura, Tomoyuki Ishigo, Ayako Watanabe, Katsuhiko Ohori, Masayuki Koyama, Nobutaka Nagano, Takefumi Fujito, Ryo Nishikawa, Akiyoshi Hashimoto, Tetsuji Miura

    Journal of diabetes   13 ( 1 )   7 - 18   2021.1

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    BACKGROUND: Muscle wasting, that is, reduction in muscle mass, is frequently observed in patients with chronic heart failure (CHF) and diabetes mellitus (DM). METHODS: We retrospectively examined 185 patients with CHF (median age of 71 years [interquartile range, 61-78 years]; 64% male) who received a dual-energy X-ray absorptiometry scan for assessment of appendicular skeletal muscle mass index (ASMI). RESULTS: Seventy patients with CHF (38%) had DM. Patients with DM had higher prevalences of ischemic heart disease and hypertension, lower levels of estimated glomerular filtration rate (eGFR) and ASMI, and higher levels of plasma renin activity (PRA) than did patients without DM. In simple regression analyses, ASMI was positively correlated with the Mini Nutritional Assessment Short Form (MNA-SF) score and levels of hemoglobin, eGFR, and fasting plasma insulin and was negatively correlated with levels of N-terminal pro B-type natriuretic peptide, PRA, and cortisol. In multiple linear regression analyses, age, MNA-SF score, DM, fasting plasma insulin level, and PRA were independently associated with ASMI. When multiple linear regression analyses were separately performed in a non-DM group and a DM group, MNA-SF score and fasting plasma insulin level were independent variables for ASMI in both groups. PRA was independently associated with ASMI in the DM group but not in the non-DM group, whereas cortisol concentration was independently associated with ASMI only in the non-DM group. CONCLUSIONS: In addition to malnutrition and reduction in plasma insulin, renin-angiotensin system activation may be responsible for the development of muscle wasting in CHF patients with DM.

    DOI： 10.1111/1753-0407.13090

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  • Clinical Risk Factors and Prognostic Impact of Osteoporosis in Patients With Chronic Heart Failure.

    Satoshi Katano, Toshiyuki Yano, Takanori Tsukada, Hidemichi Kouzu, Suguru Honma, Takuya Inoue, Yuhei Takamura, Ryohei Nagaoka, Tomoyuki Ishigo, Ayako Watanabe, Katsuhiko Ohori, Masayuki Koyama, Nobutaka Nagano, Takefumi Fujito, Ryo Nishikawa, Hiroyuki Takashima, Akiyoshi Hashimoto, Masaki Katayose, Tetsuji Miura

    Circulation journal : official journal of the Japanese Circulation Society   84 ( 12 )   2224 - 2234   2020.11

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    BACKGROUND: The clinical significance of osteoporosis in chronic heart failure (CHF) remains unclear.Methods and Results:A total of 303 CHF patients (75 years, [interquartile range (IQR) 66-82 years]; 41% female) were retrospectively examined. Bone mineral densities (BMDs) at the lumbar spine, femoral neck, and total femur were measured by using dual-energy X-ray absorptiometry (DEXA), and osteoporosis was diagnosed when the BMD at any of the 3 sites was <70% of the Young Adult Mean percentage (%YAM). The prevalence of osteoporosis in CHF patients was 40%. Patients with osteoporosis were older (79 [IQR, 74-86] vs. 72 [IQR, 62-80] years), included a large percentage of females, had slower gait speed and had a lower body mass index. Multivariate logistic regression analysis indicated that sex, BMI, gait speed, loop diuretics use and no use of direct oral anticoagulants (DOACs) were independently associated with osteoporosis. Kaplan-Meier survival curves showed that the rate of death and heart failure hospitalization was higher in patients with osteoporotic BMD at 2 or 3 sites than in patients without osteoporosis (hazard ratio 3.45, P<0.01). In multivariate Cox regression analyses, osteoporotic BMD at 2 or 3 sites was an independent predictor of adverse events after adjustment for prognostic markers. CONCLUSIONS: Loop diuretics use and no DOACs use are independently associated with osteoporosis in CHF patients. Osteoporosis is a novel predictor of worse outcome in patients with CHF.

    DOI： 10.1253/circj.CJ-20-0593

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  • 血漿中バリン/グリシン比は心不全患者における有害事象の新たな予後予測因子である(Plasma Valine-to-Glycine Ratio is a Novel Prognostic Maker for Adverse Events in Patients with Heart Failure)

    神津 英至, 片野 唆敏, 矢野 俊之, 大堀 克彦, 本間 傑, 下村 佳奈子, 井上 拓也, 高村 悠平, 高橋 遼, 西川 諒, 永野 伸卓, 小山 雅之, 藤戸 健史, 橋本 暁佳, 三浦 哲嗣

    日本循環器学会学術集会抄録集   84回   PJ37 - 3   2020.7

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  • Novel prediction equation for appendicular skeletal muscle mass estimation in patients with heart failure: Potential application in daily clinical practice. Reviewed International journal

    Satoshi Katano, Toshiyuki Yano, Katsuhiko Ohori, Nobutaka Nagano, Suguru Honma, Kanako Shimomura, Tomoyuki Ishigo, Ayako Watanabe, Remi Honma, Takefumi Fujito, Masayuki Koyama, Hidemichi Kouzu, Akiyoshi Hashimoto, Masaki Katayose, Tetsuji Miura

    European journal of preventive cardiology   2047487320904236 - 2047487320904236   2020.2

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  • Risk classification of pulmonary arterial hypertension by echocardiographic combined assessment of pulmonary vascular resistance and right ventricular function. Reviewed

    Mina Kawamukai, Akiyoshi Hashimoto, Masayuki Koyama, Nobutaka Nagano, Junichi Nishida, Atsushi Mochizuki, Hidemichi Kouzu, Atsuko Muranaka, Nobuaki Kokubu, Daigo Nagahara, Satoshi Yuda, Kazufumi Tsuchihashi, Tetsuji Miura

    Heart and vessels   34 ( 11 )   1789 - 1800   2019.11

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    Which combination of clinical parameters improves the prediction of prognosis in patients with pulmonary arterial hypertension (PAH) remains unclear. We examined whether combined assessment of pulmonary vascular resistance and right ventricular function by echocardiography is useful for classifying risks in PAH. In 41 consecutive patients with PAH (mean age of 48.9 ± 17.3 years, 31 females), a 6-min walk test, pulmonary function test, and echocardiography were performed at baseline and during PAH-specific therapies. The study endpoint was defined as a composite of cardiovascular death and hospitalization for PAH and/or right ventricular failure. During a follow-up period of 9.2 ± 8.7 months, 18 patients reached the endpoint. Multivariate regression analysis showed that the ratio of tricuspid regurgitation pressure gradient to the time-velocity integral of the right ventricular outflow tract (TRPG/TVI) and tricuspid annular plane systolic excursion (TAPSE) during PAH-specific treatment were independent prognostic predictors of the endpoint. Using cutoff values indicated by receiver operating characteristic analysis, the patients were divided into four subsets. Multivariate analyses by Cox's proportional hazards model adjusted for age, sex and body mass index indicated that subset 4 (TRPG/TVI ≥ 3.89 and TAPSE ≤ 18.9 mm) had a significantly higher event risk than did subset 1 (TRPG/TVI < 3.89 and TAPSE > 18.9 mm): HR = 25.49, 95% CI 4.70-476.97, p < 0.0001. Combined assessment of TRPG/TVI and TAPSE during adequate PAH-specific therapies enables classification of risks for death and/or progressive right heart failure in PAH.

    DOI： 10.1007/s00380-019-01429-7

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  • 心臓交感神経イメージにおいて集積低下例ほど心臓リハビリテーションの治療効果が期待できる

    中田 潤, 藤戸 健史, 大堀 克彦, 山 直也, 矢野 俊之, 橋本 暁佳, 石合 純夫, 片野 唆敏, 本間 傑, 下村 佳奈子, 蝶野 大樹, 片寄 正樹

    日本心臓核医学会ニュースレター   21 ( 2 )   120 - 120   2019.6

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  • 成人末梢性肺動脈狭窄症による肺高血圧症に対するバルーン肺動脈形成術の経験 Reviewed

    中田 潤, 鈴木 洋平, 村上 直人, 小山 雅之, 永野 伸卓, 國分 宣明, 橋本 暁佳, 土橋 和文, 三浦 哲嗣

    日本心臓病学会学術集会抄録   66回   O - 111   2018.9

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  • Nutritional Status and Energy Intake as Predictors of Functional Status After Cardiac Rehabilitation in Elderly Inpatients With Heart Failure ― A Retrospective Cohort Study ― Reviewed

    Satoshi Katano, Akiyoshi Hashimoto, Katsuhiko Ohori, Ayako Watanabe, Remi Honma, Rimi Yanase, Tomoyuki Ishigo, Takefumi Fujito, Hirofumi Ohnishi, Kazufumi Tsuchihashi, Sumio Ishiai, Tetsuji Miura

    Circulation Journal   2018.4

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    DOI： 10.1253/circj.CJ-17-1202

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  • Assessment of Left Ventricular Diastolic Function Using ECG-gated Myocardial Perfusion SPECT in Small Heart: Comparison with Ultrasound Echocardiography

    Chono Taiki, Onoguchi Masahisa, Hashimoto Akiyoshi

    Japanese Journal of Radiological Technology   74 ( 6 )   572 - 579   2018

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    Language：Japanese   Publisher：Japanese Society of Radiological Technology  

    <p><i>Background</i>: Assessment of left ventricular (LV) diastolic function is important because it is possible to detect early sign of myocardial ischemia by this assessment. The purpose of this study was to compare between electrocardiogram (ECG) -gated myocardial perfusion single photon emission computed tomography (G-SPECT) and ultrasound echocardiography in assessment of LV diastolic function in the small heart (SH). <i>Methods</i>: The study population consisted of 144 patients who underwent both G-SPECT and ultrasound echocardiography. Peak filling rate (PFR), one-third mean filling rate (1/3 MFR) and the ratio of time to PFR to the RR interval (TPFR/RR) were calculated by quantitative gated SPECT (QGS) and heart risk view-F (HRV-F). Peak early mitral annular velocity (e′) was used as the reference standard of LV diastolic function. <i>Results</i>: There were 33 patients with end-systolic volume (ESV) of ≤10 ml (SH10), 51 patients with ESV of 11–20 ml (SH 20) and 60 patients with ESV of >20 ml (normal-sized heart: NH). In SH10, PFR calculated by QGS was not correlated with e′. However, that by HRV-F was significantly correlated with e′ (<i>r=</i>0.47, <i>p=</i>0.006). On the other hand, 1/3 MFR and TPFR/RR calculated by QGS and HRV-F were not correlated with e′ in SH10 and SH20. PFR, 1/3 MFR and TPFR/RR calculated by QGS and HRV-F were correlated with e′ in NH.</p>

    DOI： 10.6009/jjrt.2018_JSRT_74.6.572

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  • Left atrial strain assessed by three-dimensional speckle tracking echocardiography predicts atrial fibrillation recurrence after catheter ablation in patients with paroxysmal atrial fibrillation Reviewed

    Atsushi Mochizuki, Satoshi Yuda, Takefumi Fujito, Mina Kawamukai, Atsuko Muranaka, Daigo Nagahara, Shinya Shimoshige, Akiyoshi Hashimoto, Tetsuji Miura

    Journal of Echocardiography   15 ( 2 )   79 - 87   2017.6

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    DOI： 10.1007/s12574-017-0329-5

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  • Soleal vein dilatation assessed by ultrasonography is an independent predictor for deep vein thrombosis after major orthopedic surgery Reviewed

    Kiyoshi Abe, Satoshi Yuda, Kenji Yasui, Ayumi Okubo, Chihiro Kobayashi, Atsuko Muranaka, Hirofumi Ohnishi, Akiyoshi Hashimoto, Atsushi Teramoto, Satoshi Nagoya, Kazufumi Tsuchihashi, Toshihiko Yamashita, Satoshi Takahashi, Tetsuji Miura

    JOURNAL OF CARDIOLOGY   69 ( 5-6 )   756 - 762   2017.5

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    DOI： 10.1016/j.jjcc.2016.07.004

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  • Improvement in automated quantitation of myocardial perfusion abnormality by using iterative reconstruction image in combination with resolution recovery, attenuation and scatter corrections for the detection of coronary artery disease Reviewed

    Taiki Chono, Masahisa Onoguchi, Takayuki Shibutani, Akiyoshi Hashimoto, Tomoaki Nakata, Naoya Yama, Kazufumi Tsuchihashi, Masamitsu Hatakenaka

    ANNALS OF NUCLEAR MEDICINE   31 ( 2 )   181 - 189   2017.2

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    DOI： 10.1007/s12149-016-1146-z

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  • High-Frequent and Spontaneously Diminishing Noises after Shock: A Case of Rare Trouble in Replacement of Implantable Cardioverter-Defibrillator Reviewed

    Shinya Shimoshige, Atsushi Mochizuki, Mina Kawamukai, Junichi Nishida, Hidemichi Kohzu, Atsuko Muranaka, Nobuyuki Kokubu, Satoshi Yuda, Mamoru Hase, Akiyoshi Hashimoto, Kazufumi Tsuchihashi, Tetsuji Miura

    journal of arrhythmia   27 ( 4 )   303   2017

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    DOI： 10.4020/jhrs.27.PJ2_066

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  • Operator Safety Zone During the Nitric Oxide Inhalation Vasoreactivity Test for Pulmonary Hypertension Patients

    Hashimoto Kanae, Hashimoto Akiyoshi, Kishimoto Masumi, Sugawara Kosuke, Funahashi Hitomi, Nakano Kota, Takahashi Hirohito, Hashimoto Syuichi, Miura Tetsuji, Tsuchihashi Kazufumi

    Advanced Biomedical Engineering   6   88 - 94   2017

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    Language：English   Publisher：Japanese Society for Medical and Biological Engineering  

    <p>Background and Objective: Acute vasoreactivity testing using inhaled nitric oxide (NO) is performed to determine the treatment strategy in patients with pulmonary hypertension. Operators of the test are exposed to NO and nitrogen dioxide (NO<sub>2</sub>) to the same extent during the test procedure, but the safety zone for operators in the catheterization laboratory is unclear. This study aimed to clarify the safety zone for operators during the NO inhalation test. Methods: The mask was placed on the examination table in the catheterization laboratory. NO was added using the INOvent<sup>®</sup> (INO-Therapeutics, LLC), which was attached to an oxygen line and delivered NO to the mask. During simulated NO inhalation tests (<i>n</i> = 10) in a catheterization laboratory, NO and NO<sub>2</sub> concentrations were measured at nine specified locations: at the mask outflow port (E0); 25 cm (E25) and 50 cm (E50) from the mask outflow port; heights of 25 cm (A25) and 50 cm (A50) above E0 and E25; and a height of 25 cm (B25) below E0 and E25. During NO inhalation testing conducted in 5 patients, concentrations of NO and NO<sub>2</sub> were measured at E0 and E25A50. The Steel-Dwass and Student t-tests were used to perform intergroup analyses. Results: NO-E0A25 (0.00 ± 0.00 ppm), NO-E25A25 (0.01 ± 0.10 ppm), NO-E0A50 (0.00 ± 0.00 ppm), and NO-E25A50 (0.00 ± 0.00 ppm) were significantly lower than NO-E0 (17.01 ± 0.22 ppm), NO-E25 (4.06 ± 0.47 ppm), and NO-E50 (1.90 ± 0.39 ppm) (<i>p</i> < 0.01, all comparisons). NO<sub>2</sub> concentrations were less than 0.1 ppm at all nine locations. NO and NO<sub>2</sub> concentrations were not affected by room temperature (20, 24, or 28℃) or the flow rate of oxygen (15 or 10 L/min). During NO inhalation testing in patients, NO-E25A50 (0.20 ± 0.45 ppm) was significantly lower than NO-E0 (7.20 ± 2.39 ppm, <i>p</i> < 0.01); however, no significant difference in the NO<sub>2</sub> concentration was seen between NO<sub>2</sub>-E0 (0.220 ± 0.179 ppm) and NO<sub>2</sub>-E25A50 (0.180 ± 0.205 ppm). Conclusions: An operator safety zone in NO vasoreactivity testing is a zone >25 cm in all directions from the mask for NO inhalation. The concentrations of NO and NO<sub>2</sub> to which an operator is exposed in the clinical setting are within the permissible exposure limits defined by the National Institute for Occupational Safety and Health.</p>

    DOI： 10.14326/abe.6.88

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  • Pulmonary vascular resistance estimated by Doppler echocardiography predicts mortality in patients with interstitial lung disease Reviewed

    Kenji Yasui, Satoshi Yuda, Kiyoshi Abe, Atsuko Muranaka, Mitsuo Otsuka, Hirofumi Ohnishi, Akiyoshi Hashimoto, Hiroki Takahashi, Kazufumi Tsuchihashi, Hiroki Takahashi, Satoshi Takahashi, Tetsuji Miura

    JOURNAL OF CARDIOLOGY   68 ( 3-4 )   300 - 307   2016.9

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    DOI： 10.1016/j.jjcc.2016.02.025

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  • Favorable response to an endothelin receptor antagonist in mitomycin-induced pulmonary veno-occlusive disease with pulmonary capillary hemangiomatosis Reviewed

    Masayuki Koyama, Toshiyuki Yano, Keisuke Kikuchi, Masashi Mizuno, Nobutaka Nagano, Akiyoshi Hashimoto, Tetsuji Miura

    INTERNATIONAL JOURNAL OF CARDIOLOGY   212   245 - 247   2016.6

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  • Clinical impact of myocardial mTORC1 activation in nonischemic dilated cardiomyopathy Reviewed

    Toshiyuki Yano, Shinya Shimoshige, Takayuki Miki, Masaya Tanno, Atsushi Mochizuki, Takefumi Fujito, Satoshi Yuda, Atsuko Muranaka, Makoto Ogasawara, Akiyoshi Hashimoto, Kazufumi Tsuchihashi, Tetsuji Miura

    JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY   91   6 - 9   2016.2

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    DOI： 10.1016/j.yjmcc.2015.12.022

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  • Does a Reduction in the Glomerular Filtration Rate Increase the Overall Severity of Coronary Artery Stenosis? Reviewed

    Junichi Nishida, Nobuaki Kokubu, Mina Kawamukai, Akiyoshi Hashimoto, Hirofumi Ohnishi, Hidemichi Kouzu, Yoshito Ohnuma, Tohru Hasegawa, Akihito Tsuchida, Tetsuji Miura

    INTERNAL MEDICINE   55 ( 8 )   871 - 877   2016

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    DOI： 10.2169/internalmedicine.55.5198

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  • Intervendor Variabilities of Left and Right Ventricular Myocardial Velocities among Three Tissue Doppler Echocardiography Systems Reviewed

    Kiyoshi Abe, Satoshi Yuda, Yasumi Sato, Kenji Yasui, Ryosuke Nishi, Kyosuke Hanada, Naoko Hashimoto, Mina Kawamukai, Hidemichi Kouzu, Atsuko Muranaka, Akiyoshi Hashimoto, Kazufumi Tsuchihashi, Naoki Watanabe, Tetsuji Miura

    ECHOCARDIOGRAPHY-A JOURNAL OF CARDIOVASCULAR ULTRASOUND AND ALLIED TECHNIQUES   32 ( 12 )   1790 - 1801   2015.12

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    DOI： 10.1111/echo.12962

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  • Cardiac tamponade leading to the diagnosis of eosinophilic granulomatosis with polyangiitis (Churg-Strauss syndrome): a case report and review of the literature Reviewed

    Toshiyuki Yano, Shutaro Ishimura, Tetsuaki Furukawa, Masayuki Koyama, Marenao Tanaka, Shinya Shimoshige, Akiyoshi Hashimoto, Tetsuji Miura

    HEART AND VESSELS   30 ( 6 )   841 - 844   2015.11

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  • "Ballooning" patterns in takotsubo cardiomyopathy reflect different clinical backgrounds and outcomes: a BOREAS-TCM study Reviewed

    Junichi Nishida, Hidemichi Kouzu, Akiyoshi Hashimoto, Takefumi Fujito, Mina Kawamukai, Atsushi Mochizuki, Atsuko Muranaka, Nobuaki Kokubu, Shinya Shimoshige, Satoshi Yuda, Mamoru Hase, Kazufumi Tsuchihashi, Tetsuji Miura

    HEART AND VESSELS   30 ( 6 )   789 - 797   2015.11

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    DOI： 10.1007/s00380-014-0548-x

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  • Pericardial Effusion and Multiple Organ Involvement Are Independent Predictors of Mortality in Patients with Systemic Light Chain Amyloidosis Reviewed

    Satoshi Yuda, Toshiaki Hayashi, Kenji Yasui, Atsuko Muranaka, Hirofumi Ohnishi, Akiyoshi Hashimoto, Tadao Ishida, Kazufumi Tsuchihashi, Yasuhisa Shinomura, Naoki Watanabe, Tetsuji Miura

    INTERNAL MEDICINE   54 ( 15 )   1833 - 1840   2015

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    DOI： 10.2169/internalmedicine.54.3500

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  • Inter-Vendor Variability of Left Ventricular Volumes and Strains Determined by Three-Dimensional Speckle Tracking Echocardiography Reviewed

    Satoshi Yuda, Yasumi Sato, Kiyoshi Abe, Mina Kawamukai, Hidemichi Kouzu, Atsuko Muranaka, Nobuaki Kokubu, Akiyoshi Hashimoto, Kazufumi Tsuchihashi, Naoki Watanabe, Tetsuji Miura

    ECHOCARDIOGRAPHY-A JOURNAL OF CARDIOVASCULAR ULTRASOUND AND ALLIED TECHNIQUES   31 ( 5 )   597 - 604   2014.5

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    DOI： 10.1111/echo.12432

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  • Rationale and design of J-ACCESS 4: Prognostic impact of reducing myocardial ischemia identified using ECG-gated myocardial perfusion SPECT in Japanese patients with coronary artery disease Reviewed

    Mamoru Nanasato, Kenichi Nakajima, Hiroshi Fujita, Kan Zen, Shun Kohsaka, Akiyoshi Hashimoto, Masao Moroi, Shigeru Fukuzawa, Taishiro Chikamori, Shigeyuki Nishimura, Akira Yamashina, Hideo Kusuoka, Atsushi Hirayama, Tsunehiko Nishimura

    JOURNAL OF CARDIOLOGY   63 ( 1-2 )   159 - 164   2014.1

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    DOI： 10.1016/j.jjcc.2013.07.006

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  • 無症状の日本人被験者において改変JASリスク層化は頸動脈プラークを予測するか(Does Revised JAS Risk Stratification Predict Carotid Plaque in Asymptomatic Japanese?)

    Kawamukai Mina, Yuda Satoshi, Fujito Takefumi, Nishida Junichi, Mochizuki Atsushi, Kouzu Hidemichi, Muranaka Atsuko, Akasaka Hiroshi, Kokubu Nobuaki, Shimoshige Shinya, Ohnishi Hirofumi, Hashimoto Akiyoshi, Saitoh Shigeyuki, Tsuchihashi Kazufumi, Watanabe Naoki, Miura Tetsuji

    Circulation Journal   77 ( Suppl.I )   97 - 98   2013.3

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    Ichushi

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  • Assessment of Left Atrial Deformation and Synchrony by Three-Dimensional Speckle-Tracking Echocardiography: Comparative Studies in Healthy Subjects and Patients with Atrial Fibrillation Reviewed

    Atsushi Mochizuki, Satoshi Yuda, Yukiko Oi, Mina Kawamukai, Junichi Nishida, Hidemichi Kouzu, Atsuko Muranaka, Nobuaki Kokubu, Shinya Shimoshige, Akiyoshi Hashimoto, Kazufumi Tsuchihashi, Naoki Watanabe, Tetsuji Miura

    JOURNAL OF THE AMERICAN SOCIETY OF ECHOCARDIOGRAPHY   26 ( 2 )   165 - 174   2013.2

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    DOI： 10.1016/j.echo.2012.10.003

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  • Prognostic value of automated SPECT scoring system for coronary artery disease in stress myocardial perfusion and fatty acid metabolism imaging Reviewed

    Tomoaki Nakata, Akiyoshi Hashimoto, Takayuki Matsuki, Keiichiro Yoshinaga, Kazumasa Tsukamoto, Nagara Tamaki

    INTERNATIONAL JOURNAL OF CARDIOVASCULAR IMAGING   29 ( 1 )   253 - 262   2013.1

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    DOI： 10.1007/s10554-012-0069-6

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  • Cardiac Mortality Assessment Improved by Evaluation of Cardiac Sympathetic Nerve Activity in Combination with Hemoglobin and Kidney Function in Chronic Heart Failure Patients Reviewed

    Takahiro Doi, Tomoaki Nakata, Akiyoshi Hashimoto, Satoshi Yuda, Takeru Wakabayashi, Hidemichi Kouzu, Naofumi Kaneko, Mamoru Hase, Kazufumi Tsuchihashi, Tetsuji Miura

    JOURNAL OF NUCLEAR MEDICINE   53 ( 5 )   731 - 740   2012.5

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    DOI： 10.2967/jnumed.111.095786

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  • Synergistic prognostic values of cardiac sympathetic innervation with left ventricular hypertrophy and left atrial size in heart failure patients without reduced left ventricular ejection fraction: a cohort study Reviewed

    Takahiro Doi, Tomoaki Nakata, Akiyoshi Hashimoto, Satoshi Yuda, Takeru Wakabayashi, Hidemichi Kouzu, Naofumi Kaneko, Mamoru Hase, Kazufumi Tsuchihashi, Tetsuji Miura

    BMJ OPEN   2 ( 6 )   2012

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    DOI： 10.1136/bmjopen-2012-001015

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  • Quantitative Measurement of Circumferential Carotid Arterial Strain by Two-Dimensional Speckle Tracking Imaging in Healthy Subjects Reviewed

    Satoshi Yuda, Reiko Kaneko, Atsuko Muranaka, Akiyoshi Hashimoto, Kazufumi Tsuchihashi, Tetsuji Miura, Naoki Watanabe, Kazuaki Shimamoto

    ECHOCARDIOGRAPHY-A JOURNAL OF CARDIOVASCULAR ULTRASOUND AND ALLIED TECHNIQUES   28 ( 8 )   899 - 906   2011.9

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    DOI： 10.1111/j.1540-8175.2011.01443.x

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  • Validation of Automated Quantitation of Myocardial Perfusion and Fatty Acid Metabolism Abnormalities on SPECT Images Reviewed

    Keiichiro Yoshinaga, Takayuki Matsuki, Akiyoshi Hashimoto, Kazumasa Tsukamoto, Tomoaki Nakata, Nagara Tamaki

    CIRCULATION JOURNAL   75 ( 9 )   2187 - 2195   2011.9

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    DOI： 10.1253/circj.CJ-10-1272

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  • Left Ventricular Hypertrophy Causes Different Changes in Longitudinal, Radial, and Circumferential Mechanics in Patients with Hypertension: A Two-Dimensional Speckle Tracking Study Reviewed

    Hidemichi Kouzu, Satoshi Yuda, Atsuko Muranaka, Takahiro Doi, Hitomi Yamamoto, Shinya Shimoshige, Mamoru Hase, Akiyoshi Hashimoto, Shigeyuki Saitoh, Kazufumi Tsuchihashi, Tetsuji Miura, Naoki Watanabe, Kazuaki Shimamoto

    JOURNAL OF THE AMERICAN SOCIETY OF ECHOCARDIOGRAPHY   24 ( 2 )   192 - 199   2011.2

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    DOI： 10.1016/j.echo.2010.10.020

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  • Impact of ICD Shock on Prognosis and Predictors of the Shock

    Mochizuki Atsushi, Shimoshige Shinya, Kawamukai Mina, Nishida Junichi, Kohzu Hidemichi, Muranaka Atsuko, Kokubu Nobuaki, Yuda Satoshi, Hase Mamoru, Hashimoto Akiyoshi, Tsuchihashi Kazufumi, Miura Tetsuji

    J Arrhythmia   27   CP1_06   2011

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    Language：English   Publisher：Japanese Heart Rhythm Society  

    <B>Background:</B> Implantable cardioverter-defibrillator (ICD) and cardiac resynchronization therapy with defibrillator (CRT-D) are established efficient therapies, but negative effects of their shocks have been reported. <B>Purpose:</B> We assessed if ICD shock or anti-tachycardia pacing (ATP) is associated with poor prognosis, and which factor predicts shocks in ICD and CRT-D patients. <B>Subjects and Methods:</B> A total of 161 consecutive patients who received ICD (n=132) or CRT-D (n=29) (age 57.2±14.3 years, 78% male, 76% non-ischemic cardiomyopathy (NICM)) were retrospectively analyzed. <B>Results:</B> During the follow-up period of 27.0±20.2 months, cardiac events occurred in 14 patients (1 sudden death, 2 death or 11 hospitalization for heart failure). Patients who experienced at least 1 ICD shock had significantly higher incidence of cardiac events and hazard risk was 1.92 (p<0.05). Such an effect on the prognosis was not observed for ATP. Multivariate analysis indicates that class I anti-arrhythmic agents and non-use of amiodarone were independent predictor of appropriate shock and that of inappropriate shock, respectively. <B>Conclusion:</B> ICD shock, but not ATP, was associated with increase in cardiac events in a group which mainly consists of NICM. Untoward effect of class I anti-arrhythmic agents and benefit of amiodarone on ICD shock incidence need to be considered.

    DOI： 10.4020/jhrs.27.CP1_06

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  • Impaired Cardiac Sympathetic Innervation and Myocardial Perfusion Are Related to Lethal Arrhythmia: Quantification of Cardiac Tracers in Patients with ICDs Reviewed

    Kimio Nishisato, Akiyoshi Hashimoto, Tomoaki Nakata, Takahiro Doi, Hitomi Yamamoto, Daigo Nagahara, Shinya Shimoshige, Satoshi Yuda, Kazufumi Tsuchihashi, Kazuaki Shimamoto

    JOURNAL OF NUCLEAR MEDICINE   51 ( 8 )   1241 - 1249   2010.8

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  • Prognostic implications of left atrial dilation evaluated by echocardiographic volume in patients with normal left atrial antero-posterior dimensions Reviewed

    Atsuko Muranaka, Satoshi Yuda, Maki Ichimura, Takahiro Doi, Hitomi Yamamoto, Hidemichi Kouzu, Naofumi Kaneko, Sakiko Fujii, Noriyuki Fujii, Shinya Shimoshige, Akiyoshi Hashimoto, Tomoaki Nakata, Kazufumi Tsuchihashi, Tetsuji Miura, Naoki Watanabe, Kazuaki Shimamoto

    Journal of Echocardiography   7 ( 4 )   63 - 69   2009.12

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    DOI： 10.1007/s12574-009-0015-3

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  • Incremental Prognostic Value of Stress/Rest Gated Perfusion SPECT in Patients With Coronary Artery Disease - Subanalysis of the J-ACCESS Study - Reviewed

    Akiyoshi Hashimoto, Tomoaki Nakata, Takeru Wakabayashi, Hideo Kusuoka, Tsunehiko Nishimura

    CIRCULATION JOURNAL   73 ( 12 )   2288 - 2293   2009.12

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  • 過体重の健常者における心房内電気力学的遅延と左心房機能の変化 2次元Speckle Tracking画像の検討(Alterations in Intra-atrial Electromechanical Delay and Left Atrial Function in Healthy Overweight Subjects: A Study of Two-dimensional Speckle Tracking Imaging)

    Muranaka Atsuko, Yuda Satoshi, Funayama Maki, Yamamoto Hitomi, Kohzu Hidemichi, Doi Takahiro, Kaneko Naofumi, Akasaka Hiroshi, Ohnishi Hirofumi, Shimoshige Shinya, Hashimoto Akiyoshi, Saitoh Shigeyuki, Nakata Tomoaki, Tsuchihashi Kazufumi, Watanabe Naoki, Shimamoto Kazuaki

    Circulation Journal   73 ( Suppl.I )   702 - 702   2009.3

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  • Quantitative assessment of left ventricular and left atrial functions by strain rate imaging in diabetic patients with and without hypertension. Reviewed

    Muranaka A, Yuda S, Tsuchihashi K, Hashimoto A, Nakata T, Miura T, Tsuzuki M, Wakabayashi C, Watanabe N, Shimamoto K

    Echocardiography (Mount Kisco, N.Y.)   26   262 - 271   2009.3

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  • 未治療高血圧患者における心形態および心機能の評価 組織ドプラ法による検討 端野・壮瞥町研究

    舟山 真希, 湯田 聡, 村中 敦子, 山本 均美, 金子 尚史, 土井 崇裕, 神津 英至, 赤坂 憲, 大西 浩文, 下重 晋也, 橋本 暁佳, 斉藤 重幸, 土橋 和文, 渡辺 直樹, 島本 和明

    日本高血圧学会総会プログラム・抄録集   31回   200 - 200   2008.10

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  • Clinical implications of midventricular obstruction and intravenous propranolol use in transient left ventricular apical ballooning (Tako-tsubo cardiomyopathy) Reviewed

    Takuji Yoshioka, Akiyoshi Hashimoto, Kazufumi Tsuchihashi, Kazuhiko Nagao, Michifumi Kyuma, Hitoshi Ooiwa, Akihiko Nozawa, Shinya Shimoshige, Mariko Eguchi, Takeru Wakabayashi, Satoshi Yuda, Mamoru Hase, Tomoaki Nakata, Kazuaki Shimamoto

    AMERICAN HEART JOURNAL   155 ( 3 )   2008.3

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  • Predicting the need for an implantable cardioverter defibrillator using cardiac metaiodobenzylguanidine activity together with plasma natriuretic peptide concentration or left ventricular function Reviewed

    Daigo Nagahara, Tomoaki Nakata, Akiyoshi Hashimoto, Takeru Wakabayashi, Michifumi Kyuma, Ryosuke Noda, Shinya Shimoshige Kikuya Uno, Kazufumi Tsuchihashi, Kazuaki Shimamoto

    JOURNAL OF NUCLEAR MEDICINE   49 ( 2 )   225 - 233   2008.2

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  • Insulin resistance functionally limits endothelium-dependent coronary vasodilation in nondiabetic patients Reviewed

    Noriyuki Fujii, Kazufumi Tsuchihashi, Hisataka Sasao, Mariko Eguchi, Hideyuki Miurakami, Mamoru Hase, Katsuhiro Higashiura, Satoshi Yuda, Akiyoshi Hashimoto, Tetsuji Miura, Nobuyuki Ura, Kazuaki Shimamoto

    HEART AND VESSELS   23 ( 1 )   9 - 15   2008.1

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    DOI： 10.1007/s00380-007-1002-0

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  • Noninvasive assessment of left atrial function by strain rate imaging in patients with hypertension: A possible beneficial effect of renin-angiotensin system inhibition on left atrial function Reviewed

    Nobuaki Kokubu, Satoshi Yuda, Kazufumi Tsuchihashi, Akiyoshi Hashimoto, Tomoaki Nakata, Tetsuji Miura, Nobuyuki Ura, Kazuhiko Nagao, Masahiro Tsuzuki, Chikashi Wakabayashi, Kazuaki Shimamoto

    HYPERTENSION RESEARCH   30 ( 1 )   13 - 21   2007.1

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  • Assessment of left ventricular ejection fraction using long-axis systolic function is independent of image quality: A study of tissue Doppler imaging and M-mode echocardiography Reviewed

    Satoshi Yuda, Yoshie Inaba, Sakiko Fujii, Nobuaki Kokubu, Takuji Yoshioka, Seiichiro Sakurai, Kimio Nishizato, Noriyuki Fujii, Akiyoshi Hashimoto, Kikuya Uno, Tomoaki Nakata, Kazufumi Tsuchihashi, Tetsuji Miura, Nobuyuki Ura, Hiroshi Natori, Kazuaki Shimamoto

    ECHOCARDIOGRAPHY-A JOURNAL OF CARDIOVASCULAR ULTRASOUND AND ALLIED TECHNIQUES   23 ( 10 )   846 - 852   2006.11

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  • Persistent insulin-sensitizing effects of sarpogrelate hydrochloride, a serotonin 2A receptor antagonist, in patients with peripheral arterial disease Reviewed

    Nobuaki Kokubu, Kazufumi Tsuchihashi, Satoshi Yuda, Mamoru Hase, Mariko Eguchi, Takeru Wakabayashi, Akiyoshi Hashimoto, Tomoaki Nakata, Tetsuji Miura, Nobuyuki Ura, Kazuhiko Nagao, Masahiro Tsuzuki, Chikashi Wakabayashi, Kazuaki Shimamoto

    CIRCULATION JOURNAL   70 ( 11 )   1451 - 1456   2006.11

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    DOI： 10.1253/circj.70.1451

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  • Serial alterations and prognostic implications of myocardial perfusion and fatty acid metabolism in patients with acute myocardial infarction Reviewed

    Akiyoshi Hashimoto, Tomoaki Nakata, Nagara Tamaki, Takeshi Kobayashi, Takayuki Matsuki, Takashi Shogase, Masayori Furudate

    CIRCULATION JOURNAL   70 ( 11 )   1466 - 1474   2006.11

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  • Early positive biomarker in relation to myocardial necrosis and impaired fatty acid metabolism in patients presenting with acute chest pain at an emergency room Reviewed

    D Nagahara, T Nakata, A Hashimoto, T Takahashi, M Kyuma, M Hase, K Tsuchihashi, K Shimamoto

    CIRCULATION JOURNAL   70 ( 4 )   419 - 425   2006.4

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  • Early defibrillation and circulatory support can provide better long-term outcomes through favorable neurological recovery in patients with out-of-hospital cardiac arrest of cardiac origin Reviewed

    M Hase, K Tsuchihashi, N Fujii, K Nishizato, N Kokubu, S Nara, Y Kurimoto, A Hashimoto, K Uno, T Miura, N Ura, Y Asai, K Shimamoto

    CIRCULATION JOURNAL   69 ( 11 )   1302 - 1307   2005.11

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    DOI： 10.1253/circj.69.1302

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  • Strain rate imaging for noninvasive functional quantification of the left atrium: Comparative studies in controls and patients with atrial fibrillation Reviewed

    Y Inaba, S Yuda, N Kobayashi, A Hashimoto, K Uno, T Nakata, K Tsuchihashi, T Miura, N Ura, K Shimamoto

    JOURNAL OF THE AMERICAN SOCIETY OF ECHOCARDIOGRAPHY   18 ( 7 )   729 - 736   2005.7

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    DOI： 10.1016/j.echo.2004.12.005

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  • ECHOCARDIOGRAPHIC DETECTION OF ELEVATED LEFT-VENTRICULAR END-DIASTOLIC PRESSURE BY LEFT ATRIAL CONTRACTILE FUNCTION Reviewed

    H MURAKAMI, S YONEKURA, K TSUCHIHASHI, T NAKATA, N HIKITA, K NAGAO, A HASHIMOTO, N TAKAHASHI, S TANAKA, O IIMURA

    AMERICAN JOURNAL OF NONINVASIVE CARDIOLOGY   7 ( 3 )   152 - 159   1993.5

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  • [Assessment of myocardial perfusion abnormality and hibernating myocardium by gated blood pool and exercise-stress thallium tomographies after successful coronary angioplasty]. Reviewed

    A Hashimoto, T Nakata, K Tsuchihashi, A Endoh, N Takahashi, K Nagao, S Tanaka, T Tsuda, M Kubota, O Iimura

    Kaku igaku. The Japanese journal of nuclear medicine   30 ( 2 )   135 - 44   1993.2

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    Cardiac function and myocardial perfusion were assessed by exercise-stress thallium SPECT and resting gated blood pool SPECT techniques before and after 47 successful coronary angioplasties. Thallium perfusion was analyzed visually and quantitatively in stress and resting studies. Left ventricular ejection fraction (LVEF) and peak filling rate (PFR) were calculated and regional wall motion was scored by amplitude and phase images in radionuclide planar and tomographic imagings. The thallium redistribution in delayed or resting SPECTs was more sensitive (87%) for detecting myocardial ischemia compared to symptoms (36%) and ECG changes (60%). An exercise capacity, LVEF, PFR, and the scores of perfusion and regional wall motion were improved significantly after coronary angioplasty. Stress thallium and gated blood pool SPECTs showed the improvements of myocardial perfusion in 159 (79%) of 201 segments and regional wall motion in 47 (51%) of 92 segments, respectively. These results suggest that the combined use of stress thallium SPECT, gated blood pool planar and SPECT techniques can contribute not only to the assessment of the efficacy of coronary angioplasty but also to detecting the mismatching of myocardial perfusion and contraction ("myocardial hibernation") in infarct-related myocardial lesions.

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  • INSPIRATORY RIGHT VENTRICULAR OUTFLOW OBSTRUCTION IN A PATIENT WITH HYPERTROPHIC CARDIOMYOPATHY Reviewed

    K TSUCHIHASHI, A TSUCHIDA, N HIKITA, S YONEKURA, M IWAKURA, A HASHIMOTO, H MURAKAMI, S TANAKA, O IIMURA

    JAPANESE HEART JOURNAL   29 ( 6 )   871 - 875   1988.11

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  • Bortezomibベースのレジメンによる治療を受けた重度心不全を有するALアミロイドーシス患者における予後および1年死亡率の予測因子(Prognosis and Predictors of 1-year Mortality in AL Amyloidosis with Severe Heart Failure who Received the Treatment with Bortezomib-based Regimens)

    藤田 雄吾, 永野 伸卓, 矢野 俊之, 小山 雅之, 村中 敦子, 橋本 暁佳, 三浦 哲嗣

    日本循環器学会学術集会抄録集   83回   OJ12 - 6   2019.3

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  • 重度の心不全を伴うALアミロイドーシスの1年死亡の予測因子(Predictors of 1-year Mortality in AL Amyloidosis with Severe Heart Failure)

    永野 伸卓, 矢野 俊之, 池田 博, 藤田 雄吾, 小山 雅之, 村中 敦子, 湯田 聡, 橋本 暁佳, 三浦 哲嗣

    日本循環器学会学術集会抄録集   82回   PJ066 - 5   2018.3

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  • Predictors of 1-year Mortality in AL Amyloidosis with Severe Heart Failure(和訳中)

    永野 伸卓, 矢野 俊之, 池田 博, 藤田 雄吾, 小山 雅之, 村中 敦子, 湯田 聡, 橋本 暁佳, 三浦 哲嗣

    日本循環器学会学術集会抄録集   82回   PJ066 - 5   2018.3

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  • Assessment of Both Energy Intake and Nutritional Status Predicts Functional Recovery after Cardiac Rehabilitation in Elderly Inpatients with Heart Failure

    Satoshi Katano, Akiyoshi Hashimoto, Katsuhiko Ohori, Yoshitaka Kiyofuji, Takefumi Fujito, Ayako Watanabe, Rimi Yanase, Remi Honma, Kazufumi Tsuchihashi, Tetsuji Miura

    JOURNAL OF CARDIAC FAILURE   22 ( 9 )   S163 - S163   2016.9

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  • 週一回の監視下外来心臓リハビリテーションが身体機能やQOLの改善に有効であった肺動脈性肺高血圧症の一症例

    片野唆敏, 片野唆敏, 橋本暁佳, 橋本暁佳, 塚田貴紀, 藤戸健史, 内澤あゆみ, 吉田玲, 岩本えりか, 根木亨, 土橋和文, 土橋和文, 片寄正樹, 三浦哲嗣

    日本心臓病学会学術集会(Web)   63rd   ROMBUNNO.O‐019 (WEB ONLY) - 398   2015.9

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  • 週一回の監視下外来心臓リハビリテーションが身体機能やQOLの改善に有効であった肺動脈性肺高血圧症の一症例

    片野 唆敏, 橋本 暁佳, 塚田 貴紀, 藤戸 健史, 内澤 あゆみ, 吉田 玲, 岩本 えりか, 根木 亨, 土橋 和文, 片寄 正樹, 三浦 哲嗣

    日本心臓病学会学術集会抄録   63回   398 - 398   2015.9

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  • Activation of mTORC1 in Cardiomyocyte is Associated with Fibrosis and Cardiomyocyte Loss in Heart Failure with Reduced Ejection Fraction

    Toshiyuki Yano, Shinya Shimoshige, Atsushi Mochizuki, Takefumi Fujito, Atsuko Muranaka, Satoshi Yuda, Masaya Tanno, Takayuki Miki, Akiyoshi Hashimoto, Kazufumi Tsuchihashi, Tetsuji Miura

    CIRCULATION   130   2014.11

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  • Do Two Scoring Systems of Coronary Stenosis, Syntax Score and Gensini Score, Similarly Predict Clinical Outcome After Pci in Patients With Stable Angina Pectoris?

    Naoto Murakami, Nobuaki Kokubu, Junichi Nishida, Mamoru Hase, Takefumi Fujito, Mina Kawamukai, Atsushi Mochizuki, Hidemichi Kouzu, Atsuko Muranaka, Shinya Shimoshige, Satoshi Yuda, Akiyoshi Hashimoto, Kazufumi Tsuchihashi, Tetsuji Miura

    CIRCULATION   130   2014.11

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  • Improved Mortality Risk Assessment in Idiopathic Dilated Cardiomyopathy by Combination of Cardiac Sympathetic Nerve Activity Imaging with Blood Biomarkers

    Takahiro Doi, Tomoaki Nakata, Akiyoshi Hashimoto, Tetsuji Miura

    JOURNAL OF CARDIAC FAILURE   20 ( 10 )   S175 - S176   2014.10

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  • Clinical Significance of mTORC1 Activation in Cardiomyocytes in Failing Hearts with Reduced Ejection Fraction

    Toshiyuki Yano, Shinya Shimoshige, Atsushi Mochizuki, Takefumi Fujito, Atsuko Muranaka, Satoshi Yuda, Masaya Tanno, Takayuki Miki, Akiyoshi Hashimoto, Tetsuji Miura

    JOURNAL OF CARDIAC FAILURE   20 ( 10 )   S188 - S188   2014.10

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  • Left Atrial Appendage Flow Velocity Predicts Recurrence of Atrial Fibrillation After Catheter Ablation

    Atsushi Mochizuki, Shinya Shimoshige, Takefumi Fujito, Mina Kawamukai, Junichi Nishida, Hidemichi Kouzu, Atsuko Muranaka, Nobuaki Kokubu, Satoshi Yuda, Mamoru Hase, Akiyoshi Hashimoto, Kazufumi Tsuchihashi, Tetsuji Miura

    CIRCULATION   128 ( 22 )   2013.11

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  • Overall severity of stenosis in the coronary artery has distinct impacts on clinical outcomes after PCI and CABG in patients with stable angina pectoris

    Nobuaki Kokubu, Junichi Nishida, Mamoru Hase, Mina Kawamukai, Atsushi Mochizuki, Atsuko Muranaka, Shinya Shimoshige, Satoshi Yuda, Akiyoshi Hashimoto, Kazufumi Tsuchihashi, Tetsuji Miura

    JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY   62 ( 18 )   B100 - B100   2013.10

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  • Therapy in the Chronic Phase and Long-term Prognosis of Takotsubo Cardiomyopathy

    37 ( 7 )   537 - 542   2013.7

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  • Pathology of Takotsubo cardiomyopathy

    72 ( 6 )   584 - 591   2012.12

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  • Reproducibility and Inter-vendor Variability of Left Ventricular Strains Determined by 3D-speckle Tracking Systems

    Satoshi Yuda, Yasumi Sato, Kiyoshi Abe, Mina Kawamukai, Atsuko Muranaka, Hidemichi Kouzu, Akiyoshi Hashimoto, Kazufumi Tsuchihashi, Naoki Watanabe, Tetsuji Miura

    CIRCULATION   126 ( 21 )   2012.11

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  • Does Stage of Chronic Kidney Disease Predict Coronary Stenosis or Cardiovascular Event in Patients with Stable Coronary Artery Disease?

    Junichi Nishida, Nobuaki Kokubu, Takefumi Fujito, Mina Kawamukai, Atsushi Mochizuki, Hidemichi Kouzu, Atsuko Muranaka, Shinya Shimoshiqe, Satoshi Yuda, Mamoru Hase, Akiyoshi Hashimoto, Kazufumi Tsuchihashi, Tetsuji Miura

    CIRCULATION   126 ( 21 )   2012.11

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  • INCIDENCE AND MORTALITY OF PULMONARY HYPERTENSION ARE SIGNIFICANTLY RAISED BY COMBINATION OF PULMONARY INTERSTITIAL FIBROSIS WITH EMPHYSEMA

    Masayuki Koyama, Akiyoshi Hashimoto, Hidemichi Kouzu, Atsuko Muranaka, Hideaki Yoshida, Satoshi Yuda, Tsuchihashi Kazufumi, Mitsuo Otsuka, Hiorki Takahashi, Tetsuji Miura

    JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY   59 ( 13 )   E1615 - E1615   2012.3

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  • ASSESSMENT OF LEFT ATRIAL DYSFUNCTION AND DYSSYNCHRONY BY 3-DIMENSIONAL SPECKLE TRACKING IN PATIENTS WITH ATRIAL FIBRILLATION

    Atsushi Mochizuki, Satoshi Yuda, Yukiko Ohi, Mina Kawamukai, Junichi Nishida, Hidemichi Kouzu, Atsuko Muranaka, Nobuaki Kokubu, Shinya Shimoshige, Mamoru Hase, Akiyoshi Hashimoto, Tsuchihashi Kazufumi, Tetsuji Miura

    JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY   59 ( 13 )   E1266 - E1266   2012.3

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  • PROGNOSIS OF VASOSPASTIC ANGINA PATIENTS WHO SURVIVED CARDIAC ARREST: DOES IMPLANTABLE CARDIOVERTER-DEFIBRILLATORS HAVE AN IMPACT?

    Junichi Nishida, Mina Kawamukai, Atsushi Mochizuki, Hidemichi Kouzu, Atsuko Muranaka, Nobuaki Kokubu, Shinya Shimoshige, Satoshi Yuda, Mamoru Hase, Akiyoshi Hashimoto, Tsuchihashi Kazufumi, Tetsuji Miura

    JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY   59 ( 13 )   E1484 - E1484   2012.3

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  • Combined pulmonary fibrosis and emphysema(CPFE)における肺高血圧合併と予後の検討

    小山 雅之, 橋本 暁佳, 神津 英至, 村中 敦子, 吉田 英昭, 湯田 聡, 土橋 和文, 三浦 哲嗣, 大塚 満雄, 高橋 弘毅

    日本内科学会雑誌   101 ( Suppl. )   166 - 166   2012.2

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  • Prognostic Value of Cardiac Sympathetic Imaging with Metaiodobenzylguanidine for the Prediction of Mortality in Patients with Cardiorenal Syndrome

    Hidemichi Kouzu, Takahiro Doi, Mina Kawamukai, Junichi Nishida, Atsushi Mochizuki, Atsuko Muranaka, Nobuaki Kokubu, Shinya Shimoshige, Satoshi Yuda, Mamoru Hase, Akiyoshi Hashimoto, Tomoaki Nakata, Kazufumi Tsuchihashi, Tetsuji Miura

    CIRCULATION   124 ( 21 )   2011.11

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  • Impacts of Gensini Score for Coronary Angiographic Severity on Outcomes of Out-of-Hospital Cardiac Arrest due to Acute Myocardial Infarction Patients.

    Nobuaki Kokubu, Mamoru Hase, Junichi Nishida, Naohiro Funayama, Atsushi Mochizuki, Atsuko Muranaka, Shinya Shimoshige, Satoshi Yuda, Akiyoshi Hashimoto, Kazufumi Tsuchihashi, Tetsuji Miura

    AMERICAN JOURNAL OF CARDIOLOGY   107 ( 8A )   5A - 5A   2011.4

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  • IMPACTS OF GENSINI SCORE FOR CORONARY ANGIOGRAPHIC SEVERITY ON OUTCOMES OF OUT-OF-HOSPITAL CARDIAC ARREST DUE TO ACUTE MYOCARDIAL INFARCTION PATIENTS

    Nobuaki Kokubu, Mamoru Hase, Junichi Nishida, Naohiro Funayama, Atsushi Mochizuki, Atsuko Muranaka, Shinya Shimoshige, Satoshi Yuda, Akiyoshi Hashimoto, Kazufumi Tsuchihashi, Tetsuji Miura

    JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY   57 ( 14 )   E1786 - E1786   2011.4

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  • Incremental Prognostic Value of Stress/Rest Gated Perfusion SPECT in Patients With Coronary Artery Disease - Subanalysis of the J-ACCESS Study (vol 73, pg 2288, 2009)

    Akiyoshi Hashimoto, Tomoaki Nakata, Takeru Wakabayashi, Hideo Kusuoka, Tsunehiko Nishimura

    CIRCULATION JOURNAL   74 ( 11 )   2505 - 2505   2010.11

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  • 地域一般住民における心形態・心機能異常の検出頻度に関する検討:端野・壮瞥町研究

    村中敦子, 湯田聡, 舟山直宏, 西田絢一, 望月敦史, 土井崇裕, 赤坂憲, 大西浩文, 下重晋也, 橋本暁佳, 斉藤重幸, 土橋和文, 渡邉直樹, 島本和明

    日本心臓病学会誌   5 ( Supplement 1 )   377   2010.8

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  • 心臓病学研究の進歩(循環器学2009年の進歩)

    土橋 和文, 橋本 暁佳, 島本 和明

    循環器専門医 : 日本循環器学会専門医誌   18 ( 1 )   101 - 106   2010.3

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  • 肥満例における高インスリン血症のIntra‐atrial Electromechanical Delayへの影響

    村中敦子, 湯田聡, 山本均美, 神津英至, 土井崇裕, 赤坂憲, 大西浩文, 下重晋也, 橋本暁佳, 斉藤重幸, 土橋和文, 渡邉直樹, 島本和明

    日本心エコー図学会学術集会抄録集   21st   141   2010

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  • Immediate Extracorporeal Cardiopulmonary Resuscitation Can Provide Better Neurological Outcomes In Patients With Out-of-hospital Cardiac Arrest

    Mamoru Hase, Nobuaki Kokubu, Hidemichi Kouzu, Satoshi Nara, Shinya Shimoshige, Satoshi Yuda, Akiyoshi Hashimoto, Kazufumi Tsuchihashi, Tetsuji Miura, Yasufumi Asai, Kazuaki Shimamoto

    CIRCULATION   120 ( 18 )   S1477 - S1477   2009.11

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  • Prognostic value of cardiac sympathetic nerve activity in heart failure patients with preserved left ventricular ejection fraction

    A. Hashimoto, T. Nakata, T. Doi, N. Kaneko, K. Tsuchihashi, K. Shimamoto, T. Takada, T. Wakabayashi

    EUROPEAN HEART JOURNAL SUPPLEMENTS   11 ( B )   S10 - S10   2009.5

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  • Massive Cerebral Embolism Originated from Ruptured Infective Mitral Annular Calcification in a Chronic Hemodialysis Patient

    Junichi Nishida, Takuto Maeda, Satoshi Yuda, Marenao Tanaka, Akiyoshi Hashimoto, Kazufumi Tsuchihashi, Kazuaki Shimamoto

    ECHOCARDIOGRAPHY-A JOURNAL OF CARDIOVASCULAR ULTRASOUND AND ALLIED TECHNIQUES   26 ( 1 )   107 - 108   2009.1

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  • 16) Adaptive-Servo Ventilator使用により心不全症状の顕著な改善を示した中枢性無呼吸合併拡張型心筋症の1例(第99回日本循環器学会北海道地方会)

    村中 敦子, 高田 明典, 横山 豊, 山本 均美, 矢野 俊之, 下重 晋也, 湯田 聡, 橋本 暁佳, 新谷 朋子, 土橋 和文, 島本 和明

    Circulation journal : official journal of the Japanese Circulation Society   72   1073 - 1073   2008.10

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  • Evaluation of Longitudinal, Radial and Circumferential Dyssynchrony in Non-ischemic Cardiomyopathy Using Two-dimensional Speckle Tracking Imaging

    YUDA Satoshi, FUNAYAMA Maki, MURANAKA Atsuko, SHIMOSHIGE Shinya, HASHIMOTO Akiyoshi, TSUCHIHASHI Kazufumi, TSUZUKI Masahiro, WAKABAYASHI Chikashi, WATANABE Naoki, SHIMAMOTO Kazuaki

    35   S332   2008.4

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  • Prediction of Appropriate Discharge of Implantable Cardioverter Defibrillator (ICD) by Impaired Myocardial Perfusion Quantified by Resting Gated Tomographic Imaging

    NISHISATO Kimio, WAKABAYASHI Takeru, HASHIMOTO Akiyoshi, SAKURAI Seiichirou, SHIMOSHIGE Shinya, YAMAMOTO Hitomi, KANEKO Naofumi, MURANAKA Atsuko, YUDA Satoshi, HASE Mamoru, NAKATA Tomoaki, TSUCHIHASHI Kazufumi, SHIMAMOTO Kazuaki

    1 ( 1 )   31 - 37   2008.1

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  • Left Atrial Function Assessed by Strain Rate Imaging : A Comparison with Transesophageal Echocardiography

    YAMAMOTO Hitomi, YUDA Satoshi, MURANAKA Atsuko, KANEKO Naofumi, FUJII Sakiko, SAKURAI Seiichiro, SHIMOSHIGE Shinya, WAKABAYASHI Takeru, HASHIMOTO Akiyoshi, TSUCHIHASHI Kazufumi, SHIMAMOTO Kazuaki

    34   S597   2007.4

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  • Determinants of Left Atrial Function by Strain Rate Imaging : A Study in Normal Subjects

    KOKUBU Nobuaki, YUDA Satoshi, MURANAKA Atsuko, YAMAMOTO Hitomi, SHIMOSHIGE Shinya, WAKABAYASHI Takeru, HASHIMOTO Akiyoshi, TSUCHIHASHI Kazufumi, SHIMAMOTO Kazuaki

    34   S371   2007.4

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  • Determinants and Reproducibilty of Carotid Arterial Wall Elasticity by the Phased-tracking Method in Normal Subjects

    SOTOYAMA Minori, YUDA Satoshi, ITO Azusa, OHGAI Nao, FUKAI Sayuri, MURANAKA Atsuko, YAMAMOTO Hitomi, HASHIMOTO Akiyoshi, TSUCHIHASHI Kazuifumi, NATORI Hiroshi, SHIMAMOTO Kazuaki

    34   S618   2007.4

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  • Predictiong lethal cardiac events by combining impaired cardiac sympathetic nerve activity with myocardial perfusion abnormality in patients with dilated cardiomyopathy

    Naofumi Kaneko, Takeru Wakabayashi, Akiyoshi Hashimoto, Hitomi Yamamoto, Atsuko Muranaka, Seiichirou Sakurai, Sakiko Fujii, Noriyuki Fujii, Shinya Shimoshige, Satoshi Yuda, Mamoru Hase, Tomoaki Nakata, Kazufumi Tsuchihashi, Kazuaki Shimamoto

    JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY   49 ( 9 )   169A - 169A   2007.3

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  • Clinical implications of mid-ventricular obstruction and intravenous propranolol use in patients with transient left ventricular apical ballooning, so-called tako-tsubo cardiornyopathy

    Akiyoshi Hashimoto, Kazufumi Tsuchihashi, Yoshioka Takuji, Shinya Shimoshige, Eguchi Mariko, Takeru Wakabayashi, Satoshi Yuda, Mamoru Hase, Tomoaki Nakata, Kazuaki Shimamoto

    JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY   49 ( 9 )   93A - 93A   2007.3

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  • Determinants of left atrial function by strain rate Imaging in healthy subjects

    N Kokubu, S Yuda, K Tsuchihashi, Y Inaba, A Hashimoto, K Uno, T Nakata, K Nagao, M Tsuzuki, C Wakabayashi, K Shimamoto

    JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY   47 ( 4 )   103A - 103A   2006.2

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  • Predicting cardiac event risk by combined assessment of cardiac sympathetic nerve activity and myocardial perfusion in patients with implantable cardioverter defibrillators

    K Nishizato, A Hashimoto, S Sakurai, N Kokubu, T Yoshioka, T Wakabayashi, S Yuda, M Hase, K Uno, T Nakata, K Tsuchihashi, K Shimamoto

    JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY   47 ( 4 )   105A - 105A   2006.2

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  • Nicorandil can affect left ventricular geometry at the chronic phase of myocardial infarction: Assessment with ECG-gated myocardial perfusion imaging

    T Yoshioka, A Hashimoto, S Sakurai, N Kokubu, T Wakabayashi, S Yuda, M Hase, K Uno, T Nakata, K Tsuchihashi, K Shimamoto

    JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY   47 ( 4 )   105A - 105A   2006.2

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  • Noninvasive assessment of left atrial function by strain rate imaging in patients with hypertension: Possible beneficial effect of renin-angiotensin system inhibition on left atrial function

    N Kokubu, S Yuda, K Tsuchihashi, Y Inaba, A Hashimoto, K Uno, T Nakata, K Nagao, M Tsuzuki, C Wakabayashi, K Shimamoto

    CIRCULATION   112 ( 17 )   U398 - U398   2005.10

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  • Assessment of ventricular systolic and diastolic function in patients with hemodialysis using tissue Doppler imaging

    YUDA Satoshi, INABA Yoshie, FUJII Sakiko, KOKUBU Nobuaki, YOSHIOKA Takuji, KAIDE Jyunichi, HASHIMOTO Akiyoshi, UNO Kikuya, TSUCHIHASHI Kazufumi, URA Nobuyuki, NATORI Hiroshi, SHIMAMOTO Kazuaki

    32   S234   2005.4

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  • Orally Administered Nicorandil Can Affect Left Ventricular Geometry at Chronic Phase of Myocardial Infarction : Assessment with ECG-gated Myocardial Perfusion Imaging(Acute Myocardial Infarction, Clinical (Diagnosis/Treatment) 2 (IHD), The 69th Annual Scientific Meeting of the Japanese Circulation Society)

    Kokubu Nobuaki, Yoshioka Takuji, Nishisato Kimio, Inaba Yoshie, Yuda Satoshi, Hase Mamoru, Hashimoto Akiyoshi, Uno Kikuya, Nakata Tomoaki, Tsuchihashi Kazufumi, Shimamoto Kazuaki

    Circulation journal : official journal of the Japanese Circulation Society   69   458 - 458   2005.3

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  • Incremental prognostic implications of brain natriuretic peptide, cardiac sympathetic nerve innervation, and noncardiac disorders in patients with heart failure

    M Kyuma, T Nakata, A Hashimoto, K Nagao, H Sasao, T Takahashi, K Tsuchihashi, K Shimamoto

    JOURNAL OF NUCLEAR MEDICINE   45 ( 2 )   155 - 163   2004.2

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  • Cardiac MIBG activity in combination with cardiac function or plasma BNP level can predict a need for ICD

    D Nagahara, T Nakata, K Uno, S Shimosige, S Yuda, A Hashimoto, K Tsuchihashi, K Shimamoto

    CIRCULATION   108 ( 17 )   544 - 544   2003.10

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  • Prognostic implications of an initial loss of cardiac metaiodobenzylguanidine uptake and diabetes mellitus in patients with left ventricular dysfunction

    T Nakata, T Wakabayashi, M Kyuma, T Takahashi, A Hashimoto, H Ogata, K Tsuchihashi, K Shimamoto

    JOURNAL OF CARDIAC FAILURE   9 ( 2 )   113 - 121   2003.4

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  • Comparison of Diagnostic Values of Stress Quantitative Gated SPECT between High-Risk Coronary Patients with and without Previous Myocardial Infarction

    Nitta Masamitsu, Nakata Tomoaki, Hashimoto Akiyoshi, Takahashi Toru, Kyuma Michifumi, Nagahara Daigo, Noda Ryosuke, Tsuchihashi Kazufumi, Shimamoto Kazuaki

    Circulation journal : official journal of the Japanese Circulation Society   67   607 - 607   2003.3

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  • Human heart-type fatty acid-binding protein as an early diagnostic and prognostic marker in acute coronary syndrome

    T Nakata, A Hashimoto, M Hase, K Tsuchihashi, K Shimamoto

    CARDIOLOGY   99 ( 2 )   96 - 104   2003

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  • High-dose dobutamine stress TI-201/I123-BMIPP dual SPECT identifies cumulatively damaged myocardial metabolism caused by repetitive episodes of demand ischemia

    A Hashimoto, M Kyuma, T Takahashi, K Uno, T Wakabayashi, T Nakata, K Tsuchihashi

    CIRCULATION   106 ( 19 )   581 - 581   2002.11

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  • Myocardial perfusion defect and impaired fatty acid metabolism in patients presenting with biomarker-positive chest pain in emergency room

    T Nakata, D Nagahara, T Takahashi, M Kyuuma, A Hashimoto, M Hase, H Ooiwa, A Hashimoto, K Nagao, T Matuki, H Kobayashi, K Tuchihashi, K Shimamoto

    CIRCULATION   106 ( 19 )   581 - 581   2002.11

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  • Quantitative assessment of right ventricular structural abnormalities by right ventricular polar mapping of single photon emission computed tomogram

    M Eguchi, K Tsuchihashi, A Hashimoto, K Uno, M Kyuma, T Takahashi, S Shimoshige, T Wakabayashi, N Nakahara, T Nakata, K Shimamoto

    NUCLEAR MEDICINE COMMUNICATIONS   23 ( 10 )   943 - 950   2002.10

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  • Validation of quantitative gated single photon emission computed tomography and an automated scoring system for the assessment of regional left ventricular systolic function

    A Hashimoto, T Nakata, T Wakabayashi, M Kyuma, T Takahashi, K Tsuchihashi, K Shimamoto

    NUCLEAR MEDICINE COMMUNICATIONS   23 ( 9 )   887 - 898   2002.9

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  • Impact of natriuretic peptides on risk stratification of heart failure by cardiac function and sympathetic nerve innervation.

    T Nakata, T Wakabayashi, A Hashimoto, M Kyuma, T Takahashi, K Shimamoto, K Tsuchihashi

    JOURNAL OF NUCLEAR MEDICINE   43 ( 5 )   184P - 185P   2002.5

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  • Identification of high-risk coronary patients by ejection fraction response and transient schemic dilatation (TID) quantified by stress gated SPECT

    Takahashi Toru, Nakata Tomoaki, Hashimoto Akiyoshi, Kyuma Michifumi, Nagahara Daigo, Nitta Masamitsu, Noda Ryosuke, Tsuchihashi Kazufumi, Shimamoto Kazuaki

    Circulation journal : official journal of the Japanese Circulation Society   66   326 - 326   2002.3

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  • Assessment of underlying etiology and cardiac sympathetic innervation to identify patients at high risk of cardiac death

    T Wakabayashi, T Nakata, A Hashimoto, S Yuda, K Tsuchihashi, MI Travin, K Shimamoto

    JOURNAL OF NUCLEAR MEDICINE   42 ( 12 )   1757 - 1767   2001.12

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  • Prediction of the timing of cardiac death by impaired cardiac sympathetic innervation assessed by metaiodobenzylguanidine

    T Nakata, M Kyuma, T Wakabayashi, A Hashimoto, T Takahashi, K Uno, K Tsuchihashi

    CIRCULATION   104 ( 17 )   721 - 721   2001.10

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  • Identification of high-risk coronary patients by functional abnormality quantified by stress gated myocardial perfusion SPECT

    T Nakata, A Hashimoto, M Kyuma, T Wakabayashi, T Takahashi, D Nagahara, K Tsuchihashi

    CIRCULATION   104 ( 17 )   637 - 637   2001.10

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  • Quantification of limited augmentation of myocardial Tc-99m-tetrofosmin uptake at exercise in stable coronary artery disease

    H Sasao, T Nakata, A Hashimoto, T Wakabayashi, T Takahashi, K Miyamoto, K Tsuchihashi, K Shimamoto

    NUCLEAR MEDICINE COMMUNICATIONS   22 ( 9 )   955 - 962   2001.9

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  • Cibenzoline and verapamil reveal focal discharges from pulmonary veins from chaotic atrial activation in chronic atrial fibrillation

    K Uno, K Miyamoto, S Shimoshige, N Kyuma, A Hashimoto, K Tsuchihashi, K Shimamoto

    EUROPEAN HEART JOURNAL   22   328 - 328   2001.9

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  • Ability of the human heart type-fatty acid binding protein to predict early adverse outcomes in patients with suspected acute coronary syndrome in emergency room: A multicenter study

    T Nakata, T Takahashi, M Hase, H Oh-iwa, A Hashimoto, K Nagao, T Matsuki, H Kobayashi, K Tsuchihashi, K Shimamoto

    JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY   37 ( 2 )   321S - 322S   2001.2

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  • Impaired exercise-related myocardial uptake of technetium-99m-tetrofosmin in relation to coronary narrowing and diabetic state - Assessment with quantitative single photon emission computed tomography

    H Sasao, T Nakata, K Tsuchihashi, T Wakabayashi, N Nakahara, A Doi, A Hashimoto, H Kobayashi, K Shimamoto

    JAPANESE HEART JOURNAL   42 ( 1 )   29 - 42   2001.1

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  • Right ventricular abnormalities assessed by myocardial single-photon emission computed tomography using technetium-99m sestamibi/tetrofosmin in right ventricle-originated ventricular tachyarrhythmias

    M Eguchi, K Tsuchihashi, T Nakata, A Hashimoto, K Shimamoto

    JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY   36 ( 6 )   1767 - 1773   2000.11

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  • Are there any differences in long-term prognostic values of altered cardiac sympathetic innervation and metaiodo-benzylguanidine kinetics between patients with left ventricular dysfunction due to idiopathic cardiomyopathy and to ischemic cardiomyopathy?

    T Wakabayashi, T Nakata, S Shimoshige, N Nakahara, A Hashimoto, K Uno, K Tsuchihashi

    CIRCULATION   102 ( 18 )   726 - 726   2000.10

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  • Detection of cardiac calcinosis in hemodialysis patients by whole-body scintigraphy with 99m-technetium methylene diphosphonate

    M Eguchi, K Tsuchihashi, H Takizawa, N Nakahara, M Hagiwara, H Ohnishi, T Torii, A Hashimoto, S Marusaki, T Nakata, N Ura, K Shimamoto

    AMERICAN JOURNAL OF NEPHROLOGY   20 ( 4 )   278 - 282   2000.7

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  • Electrocardiographic and echocardiographic abnormalities in patients with arrhythmogenic right ventricular cardiomyopathy and in their pedigrees

    N Yoshioka, K Tsuchihashi, S Yuda, A Hashimoto, K Uno, T Nakata, K Shimamoto

    AMERICAN JOURNAL OF CARDIOLOGY   85 ( 7 )   885 - +   2000.4

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  • Technetium-99m sestamibi/tetrofosmin myocardial perfusion scanning in cardiac and noncardiac sarcoidosis

    M Eguchi, K Tsuchihashi, D Hotta, A Hashimoto, H Sasao, S Yuda, T Nakata, N Shijubou, S Abe, K Shimamoto

    CARDIOLOGY   94 ( 3 )   193 - 199   2000

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  • Limitations of spontaneous reperfusion and conventional medical therapy to afford myocardial protection through antecedent angina pectoris in acute myocardial infarction

    A Hashimoto, T Nakata, T Wakabayashi, S Yuda, M Eguchi, H Sasao, K Tsuchihashi, K Shimamoto

    ANNALS OF NUCLEAR MEDICINE   13 ( 5 )   337 - 346   1999.10

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  • Cardiac BMIPP imaging in acute myocardial infarction

    T Nakata, A Hashimoto, M Eguchi

    INTERNATIONAL JOURNAL OF CARDIAC IMAGING   15 ( 1 )   21 - 26   1999.2

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  • Outcome significance of thallium-201 and iodine-123-BMIPP perfusion-metabolism mismatch in preinfarction angina

    T Nakata, A Hashimoto, H Kobayashi, K Miyamoto, K Tsuchihashi, T Miura, K Shimamoto

    JOURNAL OF NUCLEAR MEDICINE   39 ( 9 )   1492 - 1499   1998.9

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  • Sustained right ventricular dyskinesis complicated by right ventricular infarction

    T Nakata, A Hashimoto, A Kuno, K Tsuchihashi, S Yonekura, K Shimamoto

    JOURNAL OF NUCLEAR MEDICINE   38 ( 9 )   1421 - 1423   1997.9

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  • Discordancy of myocardial perfusion and metabolism augmented by pre-infarction angina and functional recovery: A possible link with protective effect of pre-infarct angina?

    T Nakata, A Hashimoto, H Kobayashi, T Tsuchihashi, K Miyamoto, S Tanaka, K Fujimori, K Ohhori, K Shimamoto

    JOURNAL OF NUCLEAR MEDICINE   38 ( 5 )   410 - 410   1997.5

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  • Regional cardiac sympathetic nerve dysfunction and the diagnostic efficacy of metaiodobenzylguanidine tomography in stable coronary artery disease

    T Nakata, K Nagao, K Tsuchihashi, A Hashimoto, S Tanaka, O Iimura

    AMERICAN JOURNAL OF CARDIOLOGY   78 ( 3 )   292 - 297   1996.8

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  • Postischemic functional recovery and BMIPP uptake after primary percutaneous transluminal coronary angioplasty in acute myocardial infarction

    A Hashimoto, T Nakata, K Tsuchihashi, S Tanaka, K Fujimori, O Iimura

    AMERICAN JOURNAL OF CARDIOLOGY   77 ( 1 )   25 - 30   1996.1

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  • [Deformity of the thorax]

    Ryoikibetsu Shokogun Shirizu   0   347 - 9   1996

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  • PREDICTION OF FUNCTIONAL RECOVERY FOLLOWING PRIMARY CORONARY ANGIOPLASTY WITH QUANTITATIVE ASSESSMENT OF MYOCARDIAL PERFUSION AND FATTY-ACID METABOLISM

    T NAKATA, A HASHIMOTO, H KOBAYASHI, K TSUCHIHASHI, S TANAKA, O LIMURA

    CIRCULATION   92 ( 8 )   3794 - 3794   1995.10

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  • Prediction of left ventricular functional recovery in patients with acute myocardial infarction using single photon emission computed tomography with thallium-201 and iodine-123-beta-methyl-p-iodophenyl-pentadecanoic acid

    A. Hashimoto, T. Nakata, K. Nagao, H. Kobayashi, M. Hase, N. Yoshioka, K. Tsuchihashi, S. Yonekura, S. Tanaka, O. Iimura

    Journal of Cardiology   26 ( 2 )   59 - 68   1995

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  • Clinical implications of mismatched uptakes of beta-methyl fatty acid analogue and thallium in infarcted myocardium: Correlations with coronary stenosis and regional wall motion abnormality

    T. Nakata, A. Hashimoto, K. Miyamoto, K. Fujimori, T. Shogase, K. Hirasawa, H. Ogata, T. Fujiwara, T. Mita, J. Katoh, S. Tanaka, H. Yamashita, T. Aburano, T. Kobayashi, M. Furudate

    Kakuigaku   32 ( 10 )   1061 - 1071   1995

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  • EXERCISE-INDUCED STV1 ELEVATION - A SIGN OF RIGHT-VENTRICULAR DYSFUNCTION IN RECENT INFERIOR MYOCARDIAL-INFARCTION

    H KOBAYASHI, K TSUCHIHASHI, A HASHIMOTO, K NAGAO, S TANAKA, K SHIMAMOTO, O IIMURA

    CANADIAN JOURNAL OF CARDIOLOGY   10 ( 3 )   355 - 362   1994.4

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  • Fatty acid metabolic and perfusion abnormalities in hypertrophied myocardium assessed by dual tracer tomography using thallium-201 and iodine-123-beta-methylpentadecanoic acid

    H. Kobayashi, T. Nakata, S. Han, N. Takahashi, K. Tsuchihashi, K. Nagao, S. Tanaka, K. Shimamoto, O. Iimura

    Journal of Cardiology   24 ( 1 )   35 - 43   1994

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  • HEMODYNAMICS OF LEFT-VENTRICULAR EJECTION AND EFFECTS OF ISOPROTERENOL INFUSION IN PATIENTS WITH SIGMOID SEPTUM - EVALUATION BY DOPPLER ECHOCARDIOGRAPHY AND TL-201 MYOCARDIAL SCINTIGRAPHY

    M IWAKURA, S YONEKURA, A ENDO, S HIKITA, F KAMEI, A HASHIMOTO, K TSUCHIHASHI, S TANAKA, O IIMURA

    JAPANESE CIRCULATION JOURNAL-ENGLISH EDITION   52 ( 9 )   1001 - 1001   1988.9

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Awards

  • 3rd International Conference of Nuclear Cardiology Young Investigator Award

    1997  

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  • 第3回世界心臓核医学会若手研究者賞

    1997  

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Research Projects

  • 心臓核医学

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    Grant type：Competitive

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