Details of a Researcher - HASHIMOTO Akiyoshi

HASHIMOTO Akiyoshi

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Affiliation	School of Medicine, Department of Health Care Administration and Management
Job title	Professor

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Degree 【 display / non-display 】

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Professional Memberships 【 display / non-display 】

　

　

　

日本心臓病学会
　

　

　

日本内科学会
　

　

　

日本核医学会
　

　

　

日本循環器学会

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Sapporo Medical University School of Medicine, 2th Dept.of Internal Medicine Instructor

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循環器内科学心臓核医学

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Misc 【 display / non-display 】

Incremental prognostic implications of brain natriuretic peptide, cardiac sympathetic nerve innervation, and noncardiac disorders in patients with heart failure.

J Nucl Med 45 155 - 63 2004
Prognostic implications of an initial loss of cardiac metaiodobenzylguanidine uptake and diabetes mellitus in patients with left ventricular dysfunction

T Nakata, T Wakabayashi, M Kyuma, T Takahashi, A Hashimoto, H Ogata, K Tsuchihashi, K Shimamoto

JOURNAL OF CARDIAC FAILURE ( CHURCHILL LIVINGSTONE INC MEDICAL PUBLISHERS ) 9 ( 2 ) 113 - 121 2003.04

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Background: Although altered cardiac sympathetic innervation is related to fatal outcome, the mechanisms and prognostic value of an initial cardiac metaiodobenzylguanidine (MIBG) defect are not known. Methods and Results: After quantitative cardiac MIBG imaging, 205 patients with left ventricular ejection fraction <50% were prospectively followed up with a primary end-point of cardiac death for 35 months. In regard to 38 cardiac deaths, consisting of 25 pump failure deaths, 11 sudden deaths, and 2 fatal acute myocardial infarctions, multivariate analysis identified diabetes mellitus as a significant independent predictor as well as reduced cardiac MIBG activity, use of nitrate, and New York Heart Association functional status. Independent of washout kinetics and cardiac function, patients with profound loss of initial MIBG uptake and those with late-phase MIBG activity of 1.74 or less had significantly greater mortality rates than did their counterparts. Initial cardiac MIBG activity closely correlated inversely with annual cardiac death rate. Conclusions: An initial cardiac MIBG defect and presence of diabetes mellitus indicate a low probability of long-term survival. The profound loss of initial MIBG activity is likely to be due to structural deficit of sympathetic neurons themselves, rather than accelerated sympathetic function, suggesting that denervation is one of mechanisms of cardiac sympathetic dysfunction leading to lethal clinical outcomes.

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Human heart-type fatty acid-binding protein as an early diagnostic and prognostic marker in acute coronary syndrome

T Nakata, A Hashimoto, M Hase, K Tsuchihashi, K Shimamoto

CARDIOLOGY ( KARGER ) 99 ( 2 ) 96 - 104 2003

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Although heart-type fatty acid-binding protein (H-FABP) can be a marker of sarcolemmal injury due to acute myocardial ischemia, the diagnostic or prognostic value is not established in patients with acute chest pain. This multicenter prospective study aimed to determine the diagnostic and prognostic values of H-FABP in 133 patients presenting to an emergency room with suspected acute coronary syndrome (ACS) by comparing with those of conventional biomarkers. H-FABP and myoglobin had greater positive results than did creatine kinase-MB or troponin T. Receiver operating characteristics analysis revealed that H-FABP was the most reliable for detection of ACS and that H-FABP had the greatest sensitivities for identification of patients requiring emergency hospitalization, coronary angiography, and interventional therapy within 7 days among the biomarkers. Thus, H-FABP can be an early diagnostic and prognostic biochemical marker, particularly within the first 6 h from the onset of chest symptoms, in patients with chest pain at an emergency department. Copyright (C) 2003 S. Karger AG, Basel.

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Validation of quantitative gated single photon emission computed tomography and an automated scoring system for the assessment of regional left ventricular systolic function.

Nucl Med Commun 23 887 - 98 2002

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Quantitative assessment of right ventricular structural abnormalities by right ventricular polar mapping of single photon emission computed tomogram.

Nucl Med Commun 23 943 - 50 2002

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