橋本　暁佳 (ハシモト　アキヨシ)

写真a

所属

医学部 病院管理学

職名

教授
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  • 医学博士

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所属学協会 【 表示 ／ 非表示 】

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    日本循環器学会

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    日本心臓病学会

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    日本内科学会

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    日本核医学会

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  • 札幌医科大学   医学部 医学科 内科学第二講座 医学部医学科臨床医学部門講座内科学第二講座   助手  

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研究キーワード 【 表示 ／ 非表示 】

  • 循環器内科学 心臓核医学

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  • Incremental prognostic implications of brain natriuretic peptide, cardiac sympathetic nerve innervation, and noncardiac disorders in patients with heart failure.

    J Nucl Med   45   155 - 63  2004年

  • Prognostic implications of an initial loss of cardiac metaiodobenzylguanidine uptake and diabetes mellitus in patients with left ventricular dysfunction

    T Nakata, T Wakabayashi, M Kyuma, T Takahashi, A Hashimoto, H Ogata, K Tsuchihashi, K Shimamoto

    JOURNAL OF CARDIAC FAILURE ( CHURCHILL LIVINGSTONE INC MEDICAL PUBLISHERS )  9 ( 2 ) 113 - 121  2003年04月

    　概要を見る

    Background: Although altered cardiac sympathetic innervation is related to fatal outcome, the mechanisms and prognostic value of an initial cardiac metaiodobenzylguanidine (MIBG) defect are not known. Methods and Results: After quantitative cardiac MIBG imaging, 205 patients with left ventricular ejection fraction <50% were prospectively followed up with a primary end-point of cardiac death for 35 months. In regard to 38 cardiac deaths, consisting of 25 pump failure deaths, 11 sudden deaths, and 2 fatal acute myocardial infarctions, multivariate analysis identified diabetes mellitus as a significant independent predictor as well as reduced cardiac MIBG activity, use of nitrate, and New York Heart Association functional status. Independent of washout kinetics and cardiac function, patients with profound loss of initial MIBG uptake and those with late-phase MIBG activity of 1.74 or less had significantly greater mortality rates than did their counterparts. Initial cardiac MIBG activity closely correlated inversely with annual cardiac death rate. Conclusions: An initial cardiac MIBG defect and presence of diabetes mellitus indicate a low probability of long-term survival. The profound loss of initial MIBG activity is likely to be due to structural deficit of sympathetic neurons themselves, rather than accelerated sympathetic function, suggesting that denervation is one of mechanisms of cardiac sympathetic dysfunction leading to lethal clinical outcomes.

    DOI PubMed CiNii

  • Human heart-type fatty acid-binding protein as an early diagnostic and prognostic marker in acute coronary syndrome

    T Nakata, A Hashimoto, M Hase, K Tsuchihashi, K Shimamoto

    CARDIOLOGY ( KARGER )  99 ( 2 ) 96 - 104  2003年

    　概要を見る

    Although heart-type fatty acid-binding protein (H-FABP) can be a marker of sarcolemmal injury due to acute myocardial ischemia, the diagnostic or prognostic value is not established in patients with acute chest pain. This multicenter prospective study aimed to determine the diagnostic and prognostic values of H-FABP in 133 patients presenting to an emergency room with suspected acute coronary syndrome (ACS) by comparing with those of conventional biomarkers. H-FABP and myoglobin had greater positive results than did creatine kinase-MB or troponin T. Receiver operating characteristics analysis revealed that H-FABP was the most reliable for detection of ACS and that H-FABP had the greatest sensitivities for identification of patients requiring emergency hospitalization, coronary angiography, and interventional therapy within 7 days among the biomarkers. Thus, H-FABP can be an early diagnostic and prognostic biochemical marker, particularly within the first 6 h from the onset of chest symptoms, in patients with chest pain at an emergency department. Copyright (C) 2003 S. Karger AG, Basel.

    DOI

  • Validation of quantitative gated single photon emission computed tomography and an automated scoring system for the assessment of regional left ventricular systolic function.

    Nucl Med Commun   23   887 - 98  2002年

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  • Quantitative assessment of right ventricular structural abnormalities by right ventricular polar mapping of single photon emission computed tomogram.

    Nucl Med Commun   23   943 - 50  2002年

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受賞 【 表示 ／ 非表示 】

  • 3rd International Conference of Nuclear Cardiology Young Investigator Award

    1997年  

  • 第3回世界心臓核医学会若手研究者賞

    1997年  

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共同研究・競争的資金等の研究課題 【 表示 ／ 非表示 】

  • 心臓核医学

  • 心血管インターベンション

  • 虚血性心疾患

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