Faculty Profiles - MIZUGUCHI Tooru

写真a

MIZUGUCHI Tooru

Organization

School of Health Science Department of Nursing Division of Fundamental and Adult Nursing Professor

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Degree

M.D., Ph.D.

Research Areas

Life Science / Medical management and medical sociology

Education

Sapporo Medical University

- 1992

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Country： Japan

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Sapporo Medical University

- 1992

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Papers

ロボット支援肝切除の導入と初期成績

村上武志, 永山稔, 今村将史, 加藤透, 久木田和晴, 水口徹, 木村康利, 竹政伊知朗

日本臨床外科学会雑誌 85 ( 2 ) 295 - 295 2024.2

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Language：Japanese Publisher：日本臨床外科学会

Ichushi

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ePROによる手術部位感染症が肝胆膵外科手術後の総医療費へ与える評価

水口徹, 石貫智裕, 加藤透, 合田恵理香, 進士誠一, 吉田寛, 渡邉学, 横尾英樹, 柴田英貴, 青木武士, 問山裕二, 西森英史, 秦史壯

日本外科感染症学会雑誌 20 ( 3 ) 474 - 474 2023.11

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Ichushi

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オンラインPRO情報システムによるがん手術患者の術創部感染症の危険因子と予後の検証

石貫智裕, 久冨五郎, 島宏彰, 和田朝香, 青木武士, 吉田寛, 渡邉学, 長田拓哉, 横尾英樹, 問山裕二, 大西浩文, 林宏至, 森脇健介, 大柳俊夫, 水口徹

日本癌治療学会学術集会抄録集 61回 P61 - 5 2023.10

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Language：Japanese Publisher：(一社)日本癌治療学会

Ichushi

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【周術期感染管理マニュアル】肝臓手術における周術期感染管理

永山稔, 石貫智裕, 水口徹

日本外科感染症学会雑誌 20 ( 2 ) 113 - 116 2023.9

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Other Link： https://search.jamas.or.jp/default/link?pub_year=2023&ichushi_jid=J04188&link_issn=&doc_id=20230928370009&doc_link_id=10.24679%2Fgekakansen.20.2_113&url=https%3A%2F%2Fdoi.org%2F10.24679%2Fgekakansen.20.2_113&type=J-STAGE&icon=https%3A%2F%2Fjk04.jamas.or.jp%2Ficon%2F00007_3.gif

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Synergistic antitumor effect of histone deacetylase class IIa inhibitor with lenvatinib in hepatocellular carcinoma. International journal

Ryo Ito, Koji Miyanishi, Tomohiro Kubo, Kota Hamaguchi, Takahiro Osuga, Shingo Tanaka, Hiroyuki Ohnuma, Kazuyuki Murase, Kohichi Takada, Minoru Nagayama, Yasutoshi Kimura, Toru Mizuguchi, Ichiro Takemasa, Junji Kato

Hepatology international 17 ( 3 ) 735 - 744 2023.6

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BACKGROUND: Histone deacetylase (HDAC) class I and IIa are highly expressed in hepatocellular carcinoma (HCC) and associated with decreased survival. However, clinically used pan and class I inhibitors have serious adverse events. In this study, we assessed the antitumor effects and tolerability of class IIa HDAC inhibitor (HDACI) with lenvatinib, which is a standard therapy for HCC. METHODS AND RESULT: Combination therapy with class IIa HDACI and lenvatinib exerted synergistic antitumor effect in human HCC cell lines. In mouse models, this therapy showed significant antitumor effects, and few adverse events occurred. In immunoblotting, the expression of fibroblast growth factor receptor 4 (FGFR4) and fibroblast growth factor 19 (FGF19) was high in cell lines that showed a high antitumor effect. In addition, class IIa HDACI administration decreased the expression of FGFR4. In the small interfering RNA (siRNA) analysis, knockdown of HDAC9, which is an isoform of HDAC class IIa, reduced the expression of FGFR4 and induced apoptosis. Immunohistochemistry of human clinical specimens showed a positivity rate of 32% for FGFR4 and 84% for HDAC9 in HCC, and all FGFR4-positive patients were HDAC9 positive. CONCLUSION: Class IIa HDACI and lenvatinib combination therapy induces apoptosis by downregulating FGFR4 and blocking the FGFR signaling in FGFR4-positive HCC cell lines and has demonstrated synergistic antitumor effects and safety. This combination therapy overcomes the problems of conventional therapies and will be beneficial for FGFR4-positive HCC patients.

DOI： 10.1007/s12072-023-10484-2

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肝がん患者のSSI発生に関連する要因の検討

石貫智裕, 合田恵理香, 巽博臣, 加藤透, 原田敬介, 升田好樹, 大西浩文, 秦史壯, 大柳俊夫, 水口徹

日本外科系連合学会誌 48 ( 3 ) 409 - 409 2023.5

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肝がん患者のSSI発生に関連する要因の検討

石貫智裕, 合田恵理香, 巽博臣, 加藤透, 原田敬介, 升田好樹, 大西浩文, 秦史壯, 大柳俊夫, 水口徹

日本外科系連合学会誌 48 ( 3 ) 409 - 409 2023.5

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Positional advantages of supine MRI for diagnosis prior to breast‑conserving surgery. International journal

Goro Kutomi, Hiroaki Shima, Daisuke Kyuno, Fukino Satomi, Asaka Wada, Yoko Kuga, Minoru Okazaki, Akira Okazaki, Hideji Masuoka, Toshihiko Mikami, Yuichi Yuyama, Takashi Matsuno, Tosei Ohmura, Hidekazu Kameshima, Toru Mizuguchi, Ichiro Takemasa

Molecular and clinical oncology 18 ( 5 ) 44 - 44 2023.5

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The present study aimed to evaluate the rate of positive surgical margins for magnetic resonance imaging (MRI) performed in the supine position prior to breast-conserving surgery (BCS). The rate of positive surgical margins and the clinicopathological factors were examined in consecutive patients with BCS who underwent preoperative MRI performed in the supine position at Sapporo Medical University Hospital (Sapporo, Japan) and related hospitals and clinics between January 2012 and December 2013. Of 1,175 eligible patients, 1,150 were included after excluding 25 patients with either bilateral breast cancer or stage IV disease. Positive margin was defined as no cancer seen on the resected margin. The primary endpoint was the rate of positive surgical margins when preoperative MRI was performed in the supine position and the secondary endpoint was identification of the factors that predict positive margins. Of the 1,150 female patients (median age, 55 years; range, 29-97 years) who underwent BCS for breast cancer following MRI performed in the supine position, 215 (18.8%) had positive margins, which is similar to the rate with MRI in the prone position, and 930 (81.2%) had negative margins. The rate of positive surgical margins in patients of the human epidermal growth factor receptor 2 (HER2) type was significantly higher than that in the non-HER2 type group (6.5 and 2.9%; χ2 P=0.0103). There was no increase in the rate of positive margins in breast cancers with a diameter of >T2. The rate of positive surgical margins following MRI performed in the supine position was 18.8%. Supine MRI appears to be suitable for informing on the extent of resection of breast cancer.

DOI： 10.3892/mco.2023.2640

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当科における肝硬変合併肝細胞癌に対する腹腔鏡下肝切除術と周術期成績

永山稔, 加藤透, 村上武志, 久木田和晴, 今村将史, 水口徹, 伊東竜哉, 信岡隆幸, 木村康利, 竹政伊知朗

日本消化器外科学会雑誌 55 ( Suppl.2 ) 328 - 328 2022.10

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肝臓

水口徹, 石貫智裕, 張苓, 巽博臣, 久野芳佳, 原田敬介, 大西浩文, 加藤透, 沖田憲司, 川本雅樹, 永山稔, 竹政伊知朗, 大柳俊夫

日本外科感染症学会雑誌 19 ( 1 ) 230 - 230 2022.10

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一次縫合創に対するNPWTの最適な適応とは SSI予防ガイドラインの次期改定に必要な予防的NPWTに関する有効性の再考

水口徹, 石貫智裕, 張苓, 巽博臣, 久野芳佳, 原田敬介, 大西浩文, 加藤透, 沖田憲司, 川本雅樹, 目黒誠, 秦史壯, 大柳俊夫

日本外科感染症学会雑誌 19 ( 1 ) 185 - 185 2022.10

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当科における腹腔鏡下肝葉切除の手技と成績

加藤透, 永山稔, 木村康利, 今村将史, 久木田和晴, 村上武志, 水口徹, 竹政伊知朗

日本臨床外科学会雑誌 83 ( 増刊 ) S458 - S458 2022.10

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一次縫合創に対するNPWTの最適な適応とは SSI予防ガイドラインの次期改定に必要な予防的NPWTに関する有効性の再考

水口徹, 石貫智裕, 張苓, 巽博臣, 久野芳佳, 原田敬介, 大西浩文, 加藤透, 沖田憲司, 川本雅樹, 目黒誠, 秦史壯, 大柳俊夫

日本外科感染症学会雑誌 19 ( 1 ) 185 - 185 2022.10

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肝胆膵外科における周術期感染対策肝切除後の腹腔内合併症に対する治療方法の検討

永山稔, 木村康利, 加藤透, 村上武志, 久木田和晴, 今村将史, 水口徹, 竹政伊知朗

日本外科感染症学会雑誌 19 ( 1 ) 153 - 153 2022.10

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肝臓

水口徹, 石貫智裕, 張苓, 巽博臣, 久野芳佳, 原田敬介, 大西浩文, 加藤透, 沖田憲司, 川本雅樹, 永山稔, 竹政伊知朗, 大柳俊夫

日本外科感染症学会雑誌 19 ( 1 ) 230 - 230 2022.10

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【ここまで進んだERAS】肝外科

石貫智裕, 太田盛道, 小野崎由香, 加藤透, 川本雅樹, 目黒誠, 永山稔, 竹政伊知朗, 大柳俊夫, 水口徹

消化器外科 45 ( 9 ) 1003 - 1010 2022.9

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Ichushi

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Current standard values of health utility scores for evaluating cost-effectiveness in liver disease: A meta-analysis

Tomohiro Ishinuki, Shigenori Ota, Kohei Harada, Masaki Kawamoto, Makoto Meguro, Goro Kutomi, Hiroomi Tatsumi, Keisuke Harada, Koji Miyanishi, Toru Kato, Toshio Ohyanagi, Thomas T Hui, Toru Mizuguchi

World Journal of Gastroenterology 28 ( 31 ) 4442 - 4455 2022.8

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Publishing type：Research paper (scientific journal) Publisher：Baishideng Publishing Group Inc.

DOI： 10.3748/wjg.v28.i31.4442

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Association between Hepatic Oxidative Stress Related Factors and Activation of Wnt/β-Catenin Signaling in NAFLD-Induced Hepatocellular Carcinoma. International journal

Kota Hamaguchi, Koji Miyanishi, Takahiro Osuga, Shingo Tanaka, Ryo Ito, Hiroki Sakamoto, Tomohiro Kubo, Hiroyuki Ohnuma, Kazuyuki Murase, Kohichi Takada, Minoru Nagayama, Yasutoshi Kimura, Toru Mizuguchi, Ichiro Takemasa, Junji Kato

Cancers 14 ( 9 ) 2022.4

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We investigated the association between iron overload, oxidative stress (8-oxo-7,8-dihydroguanine: 8-oxo-dG scores), Wnt/β-catenin pathway activation (expression of glutamine synthetase: GS), and tumor hyperintensity in the Gd-EOB-DTPA-enhanced MRI hepatobiliary phase (relative enhancement ratio: RER). This was a retrospective analysis of 94 hepatocellular carcinoma (HCC) patients who underwent surgical resection. In HBV-, HCV-, and alcohol-associated HCC, serum ferritin levels in the high and low RER groups were equivalent. In contrast, ferritin levels were elevated in the 'high RER' group of patients with nonalcoholic fatty liver disease (NAFLD)-HCC. As predictors of GS positivity, high RER had a sensitivity of 57.2% and a specificity of 100%. High serum ferritin had a sensitivity of 85.7% and a specificity of 85.7%. All cases with serum ferritin ≥275.5 ng/mL and high RER were 8-oxo-dG- and iron staining-positive. Additionally, GS positivity was seen in all cases with "serum ferritin levels above the upper limits or iron staining-positive" and '8-oxo-dG high' cases. Therefore, combining serum ferritin levels with RER may increase the accuracy with which activated Wnt/β-catenin signaling is predicted in NAFLD-HCC. We suggest that 8-oxo-dG accumulates following increased oxidative stress due to hepatic tissue iron deposition; this may activate Wnt/β-catenin signaling and trigger carcinogenesis.

DOI： 10.3390/cancers14092066

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高齢者におけるMajor hepatectomyに伴う術後合併症にGeriatric Nutritional Risk Index(GNRI)で評価した栄養状態が及ぼす影響

加藤透, 永山稔, 木村康利, 今村将史, 久木田和晴, 村上武志, 水口徹, 竹政伊知朗

日本臨床外科学会雑誌 83 ( 3 ) 599 - 600 2022.3

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回腸瘻閉鎖術と腹腔鏡下肝切除術を同時施行した2例

永山稔, 木村康利, 今村将史, 村上武志, 加藤透, 久木田和晴, 伊東竜哉, 水口徹, 竹政伊知朗

日本外科感染症学会雑誌 18 ( 1 ) 252 - 252 2021.11

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An Optimal Timing for Removing a Drain After Breast Surgery: A Systematic Review and Meta-Analysis. International journal

Hiroaki Shima, Goro Kutomi, Kiminori Sato, Yoko Kuga, Asaka Wada, Fukino Satomi, Satoko Uno, Noriko Nisikawa, Hidekazu Kameshima, Tosei Ohmura, Toru Mizuguchi, Ichiro Takemasa

The Journal of surgical research 267 267 - 273 2021.11

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BACKGROUND: In clinical practice, drains had been routinely used for reducing seroma formation after breast surgery. However, an optimal timing to remove drains does not identify yet. METHODS: This study aimed to compare the clinical outcome, such as seroma formation, surgical site infection (SSI), and a length of hospital stay between early removal and late removal. A systematic review was performed using PubMed, MEDLINE, and the Cochrane Library. Breast cancer patients who received surgery using drains were eligible. Those parameters were compared between early vs late removal. RESULTS: Eleven studies included in this meta-analysis. Seroma formation in the early removal group was significantly higher than the one in the late removal group (RR = 1.58: 95%CI [1.25-2.01], P = 0.0001), meanwhile no significant difference was found among the groups for SSI (RR = 0.82: 95%CI [0.51-1.31], P= 0.40). A length of hospital stay in the early removal group was also significantly shorter than late removal (RR -3.31: 95%CI [-5.13-1.49], P = 0.0004). CONCLUSIONS: Seroma formation was significantly higher in patients who had early drain removal. Conversely, SSI incidence was low, and early removal did not increase SSI incidence. In conclusion, early drain removal has no proved clinical benefit in these settings besides reduction of hospital stays.

DOI： 10.1016/j.jss.2021.05.031

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Maturation of robotic liver resection during the last decade: A systematic review and meta-analysis

Tomohiro Ishinuki, Shigenori Ota, Kohei Harada, Makoto Meguro, Masaki Kawamoto, Goro Kutomi, Hiroomi Tatsumi, Keisuke Harada, Koji Miyanishi, Ichiro Takemasa, Toshio Ohyanagi, Thomas T Hui, Toru Mizuguchi

World Journal of Meta-Analysis 9 ( 5 ) 462 - 473 2021.10

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Publishing type：Research paper (scientific journal) Publisher：Baishideng Publishing Group Inc.

DOI： 10.13105/wjma.v9.i5.462

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Major hepatectomyにおけるGeriatric Nutritional Risk Index(GNRI)で評価した栄養状態と短期予後との関連に関する検討

永山稔, 木村康利, 今村将史, 久木田和晴, 村上武志, 加藤透, 伊東竜哉, 信岡隆幸, 水口徹, 竹政伊知朗

日本臨床外科学会雑誌 82 ( 増刊 ) S773 - S773 2021.10

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Extracellular vesicles containing miR-146a-5p secreted by bone marrow mesenchymal cells activate hepatocytic progenitors in regenerating rat livers. International journal

Norihisa Ichinohe, Masayuki Ishii, Naoki Tanimizu, Toru Mizuguchi, Yusuke Yoshioka, Takahiro Ochiya, Hiromu Suzuki, Toshihiro Mitaka

Stem cell research & therapy 12 ( 1 ) 312 - 312 2021.5

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BACKGROUND: Small hepatocyte-like progenitor cells (SHPCs) appear to form transient clusters in rat livers treated with retrorsine (Ret) and 70% partial hepatectomy (PH). We previously reported that the expansion of SHPCs was amplified in Ret/PH-treated rat livers transplanted with Thy1+ cells derived from D-galactosamine-treated injured livers. Extracellular vesicles (EVs) produced by hepatic Thy1+ donor cells activated SHPCs via interleukin (IL)-17 receptor B signaling. As bone marrow-derived mesenchymal cells (BM-MCs) also express Thy1, we aimed to determine whether BM-MCs could also promote the growth of SHPCs. METHODS: BM-MCs were isolated from dipeptidyl-peptidase IV (DPPIV)-positive rats. BM-MCs or BM-MC-derived EVs were administered to DPPIV-negative Ret/PH rat livers, and the growth and the characteristics of SHPC clusters were evaluated 14 days post-treatment. miRNA microarrays and cytokine arrays examined soluble factors within EVs. Small hepatocytes (SHs) isolated from an adult rat liver were used to identify factors enhancing hepatocytic progenitor cells growth. RESULTS: The recipient's livers were enlarged at 2 weeks post-BM-MC transplantation. The number and the size of SHPCs increased remarkably in livers transplanted with BM-MCs. BM-MC-derived EVs also stimulated SHPC growth. Comprehensive analyses revealed that BM-MC-derived EVs contained miR-146a-5p, interleukin-6, and stem cell factor, which could enhance SHs' proliferation. Administration of EVs derived from the miR-146a-5p-transfected BM-MCs to Ret/PH rat livers remarkably enhanced the expansion of SHPCs. CONCLUSIONS: miR-146a-5p involved in EVs produced by BM-MCs may play a major role in accelerating liver regeneration by activating the intrinsic hepatocytic progenitor cells.

DOI： 10.1186/s13287-021-02387-6

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外科周術期感染予防に関するガイドライン SSI予防の周術期管理ガイドライン発表から2年経過して

水口徹, 石貫智裕, 太田盛道, 沖田憲司, 西舘敏彦, 久野芳佳, 首藤英里香, 城丸瑞恵, 堀口雅美, 秦史壮, 角隆臣, 大柳俊夫, 久冨五郎, 永山稔, 竹政伊知朗

日本外科系連合学会誌 46 ( 3 ) 323 - 323 2021.5

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Health-related quality of life in patients that have undergone liver resection: A systematic review and meta-analysis

Tomohiro Ishinuki, Shigenori Ota, Kohei Harada, Hiroomi Tatsumi, Keisuke Harada, Koji Miyanishi, Minoru Nagayama, Ichiro Takemasa, Toshio Ohyanagi, Thomas T Hui, Toru Mizuguchi

World Journal of Meta-Analysis 9 ( 1 ) 88 - 100 2021.2

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Publishing type：Research paper (scientific journal) Publisher：Baishideng Publishing Group Inc.

DOI： 10.13105/wjma.v9.i1.88

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Surgical advantage of ultrasonically activated devices during axillary lymph node dissection for breast cancer

Goro Kutomi, Hiroaki Shima, Hideki Maeda, Fukino Satomi, Asaka Wada, Kiminori Sato, Toru Mizuguchi, Ichiro Takemasa

International Surgery 105 ( 1-3 ) 623 - 627 2021

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Language：English Publishing type：Research paper (scientific journal) Publisher：International College of Surgeons

DOI： 10.9738/INTSURG-D-20-00032.1

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Nature of the liver volume depending on the gender and age assessing volumetry from a reconstruction of the computed tomography. Reviewed International journal

Kohei Harada, Tomohiro Ishinuki, Yoshiya Ohashi, Takeo Tanaka, Ayaka Chiba, Kanako Numasawa, Tatsuya Imai, Shun Hayasaka, Takahito Tsugiki, Koji Miyanishi, Minoru Nagayama, Ichiro Takemasa, Junji Kato, Toru Mizuguchi

PloS one 16 ( 12 ) e0261094 2021

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Although the liver is a regenerating organ, excessive loss of liver volume (LV) can cause fatal liver failure. It is unclear whether LV is correlated with age; however, it is known that liver function decreases with age. In addition, the gender-related role of LV remains unclear. This study aimed to investigate the changes in LV by age and gender. Between January and December 2018, 374 consecutive patients who underwent abdominal multidetector computed tomography (MDCT) for any abdominal examinations were enrolled. LV was evaluated using MDCT. The relationship between the LV and body mass index (BMI), body surface area (BSA), age, and gender was investigated. The modified LV (mLV) was calculated by a formula measured LV × 1.5/BSA. LV correlated to BSA more than to BMI in both the males (R: 0.559 vs. 0.416) and females (R: 0.479 vs. 0.300) in our study. Age was negatively correlated to LV and BSA, and correlated to LV more than to BSA in males (R: 0.546 vs. 0.393) and females (R: 0.506 vs. 0.385). In addition, the absolute slope between age and LV in the males was higher than that in the females (14.1 vs. 10.2, respectively). Furthermore, the absolute slope of age and mLV in the males was slightly higher than in the females (9.1 vs. 7.3, respectively). In conclusion, LV in the normal liver is correlated to age rather than the one in the diseased liver. Liver volume in the males decreased more with age than LV in the females.

DOI： 10.1371/journal.pone.0261094

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Effect of Rikkunshito, a Traditional Japanese Herbal Medicine, on Delayed Gastric Emptying and Oral Dietary Intake After Pancreaticoduodenectomy: A Prospective, Randomized, Single-Center, Open-Labeled Study. International journal

Hiroshi Yamaguchi, Yasutoshi Kimura, Masafumi Imamura, Minoru Nagayama, Tatsuya Ito, Daisuke Kyuno, Tsuyoshi Kono, Akina Kimura, Emi Akizuki, Toshihiko Nishidate, Kenji Okita, Takayuki Nobuoka, Toru Mizuguchi, Koichi Hirata, Ichiro Takemasa

Clinical and experimental gastroenterology 13 577 - 587 2020.12

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Introduction: Delayed gastric emptying (DGE) remains an important problem after pancreaticoduodenectomy (PD). There is a lack of effective treatments for early recovery of oral dietary intake. Rikkunshito (RKT), a Japanese herbal medicine, has been gaining attention as a facilitator of gastric emptying. We evaluated the effects of RKT on DGE after PD. Methods: In this prospective, randomized, open-labeled study, patients were randomly allocated before PD in a 1:1 ratio to the RKT group or the control group that received no additional treatment. The RKT group received 2.5 g of RKT three times daily (7.5 g/day) from postoperative day (POD) 1 to POD 21. The primary endpoint was the incidence of DGE. Secondary endpoints were short-term postoperative outcomes including oral dietary intake volume and perioperative changes in levels of the hormones ghrelin and leptin. Patients were observed until hospital discharge. Results: Twenty-six patients in each group (n = 52) completed the protocol treatment and were included in the analysis set. There were no statistically significant differences in basic characteristics and operative factors. The overall incidence of DGE was not statistically different between the RKT and control groups (30.8% vs 30.8%, p>0.9999). There were no statistically significant differences in the amount of postoperative oral dietary intake represented by total dietary intake (TDI) up to POD 14 and POD 21, complications, and length of hospital stay. No adverse events related to this study were observed. In the RKT group, total ghrelin and acyl-ghrelin were significantly upregulated and leptin was significantly downregulated earlier than in the control group. Conclusion: RKT treatment from POD 1 to 21 did not reduce the incidence of DGE and had no clinically beneficial effect on short-term postoperative outcomes irrespective of changes in hormone levels.

DOI： 10.2147/CEG.S252913

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The Unique Mental Impacts of Breast-Conserving Surgery and Mastectomy According to a Multi-Centered Cross Sectional Survey Conducted in Japan

Yuri Hazawa, Goro Kutomi, Hiroaki Shima, Toshio Honma, Tosei Ohmura, Asaka Wada, Toshihiko Mikami, Miki Hotta, Momoka Narumi, Tomohiro Ishinuki, Yoshika Kuno, Makoto Meguro, Ichiro Takemasa, Minoru Okazaki, Hideji Masuoka, Kazuaki Asaishi, Toshio Ohyanagi, Thomas T. Hui, Toru Mizuguchi

Archives of Breast Cancer 119 - 126 2020.8

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Background: Improving health-related quality of life (HRQOL) has become a fundamental goal of breast cancer management. This study aimed to examine the differences between the QOL outcomes of breast-conserving surgery (BCS) and mastectomy. We also established structural equation models for BCS and mastectomy to elucidate their unique effects on QOL.Methods: Between July 2019 and November 2019, 254 patients, who were scheduled to visit one of four clinics, were recruited for this study. We evaluated HRQOL using various questionnaires, such as the BREAST-Q, EQ-5D-5L, and Hospital Anxiety and Depression Scale (HADS). The relationships among the examined clinical indicators were evaluated using structural equation modeling (SEM). Results: The QOL scores of the BCS group were better than those of the mastectomy group (0.85±0.129 vs. 0.81±0.12, P=0.020). Also, anxiety (2.94±2.95 vs. 3.81±3.08, P=0.025) and depression (2.55±2.77 vs. 3.74±3.19, P=0.002) were less severe in the BCS group than in the mastectomy group. Furthermore, the relationships among QOL status and mental health status were more complex in the BCS group than in the mastectomy group (Chi-square minimization p-value: 0.231 vs. 0.469, respectively). Also, depression directly affected QOL in the mastectomy group (R=-0.47), but not in the BCS group.Conclusions: There were differences in QOL and mental health between the BCS and mastectomy groups. SEM is useful for identifying such differences, which can be used to develop strategies for improving QOL.

DOI： 10.32768/abc.202073119-126

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【外科栄養-最新のアプローチ】肝臓外科手術の周術期栄養管理

水口徹, 永山稔, 山口洋志, 石貫智裕, 久野芳佳, 今村将史, 竹政伊知朗, 木村康利

外科 82 ( 4 ) 357 - 363 2020.4

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Other Link： https://search.jamas.or.jp/default/link?pub_year=2020&ichushi_jid=J00393&link_issn=&doc_id=20200420210010&doc_link_id=issn%3D0016-593X%26volume%3D82%26issue%3D4%26spage%3D357&url=http%3A%2F%2Fwww.pieronline.jp%2Fopenurl%3Fissn%3D0016-593X%26volume%3D82%26issue%3D4%26spage%3D357&type=PierOnline&icon=https%3A%2F%2Fjk04.jamas.or.jp%2Ficon%2F00005_2.gif

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Self‐Renewal Capability of Hepatocytic Parental Progenitor Cells Derived From Adult Rat Liver Is Maintained Long Term When Cultured on Laminin 111 in Serum‐Free Medium

Junichi Kino, Norihisa Ichinohe, Masayuki Ishii, Hiromu Suzuki, Toru Mizuguchi, Naoki Tanimizu, Toshihiro Mitaka

Hepatology Communications 4 ( 1 ) 21 - 37 2020.1

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Publishing type：Research paper (scientific journal) Publisher：Wiley

Other Link： https://onlinelibrary.wiley.com/doi/full-xml/10.1002/hep4.1442

DOI： 10.1002/hep4.1442

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Central pancreatectomy in portal annular pancreas for metastatic renal cell carcinoma: a case report

Hiroshi Yamaguchi, Yasutoshi Kimura, Minoru Nagayama, Masafumi Imamura, Shingo Tanaka, Makoto Yoshida, Eiji Yoshida, Hiroki Fujino, Takashi Machiki, Koji Miyanishi, Toru Mizuguchi, Junji Kato, Ichiro Takemasa

World Journal of Surgical Oncology 17 ( 1 ) 2019.12

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Publishing type：Research paper (scientific journal) Publisher：Springer Science and Business Media LLC

Other Link： http://link.springer.com/article/10.1186/s12957-019-1622-8/fulltext.html

DOI： 10.1186/s12957-019-1622-8

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Immunohistological analysis of pancreatic carcinoma after vaccination with survivin 2B peptide: Analysis of an autopsy series. International journal

Terufumi Kubo, Giichiro Tsurita, Yoshihiko Hirohashi, Hiroshi Yasui, Yasunori Ota, Kazue Watanabe, Aiko Murai, Kazuhiko Matsuo, Hiroko Asanuma, Hiroaki Shima, Satoshi Wada, Munehide Nakatsugawa, Takayuki Kanaseki, Tomohide Tsukahara, Toru Mizuguchi, Koichi Hirata, Ichiro Takemasa, Kohzoh Imai, Noriyuki Sato, Toshihiko Torigoe

Cancer science 110 ( 8 ) 2386 - 2395 2019.8

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Immune checkpoint inhibitors (ICIs) have revolutionized the treatment of cancer by providing new options in addition to existing therapies. However, peptide vaccination therapies still represent an attractive approach, because of the antigen specificity. We identified survivin 2B peptide (SVN-2B), a 9-mer antigenic peptide encoded by survivin, and an SVN-2B peptide vaccine-based phase II randomized clinical trial targeting unresectable and refractory pancreatic carcinoma was undertaken. The SVN-2B peptide vaccine did not have any statistically significant clinical benefits in that study. Therefore, we undertook an autopsy study to analyze the immune status of the pancreatic cancer lesions at the histological level. Autopsies were carried out in 13 patients who had died of pancreatic cancer, including 7 who had received SVN-2B peptide vaccination and 6 who had not, as negative controls. The expression of immune-related molecules was analyzed by immunohistochemical staining. Cytotoxic T lymphocytes were analyzed by tetramer staining and enzyme-linked immunospot assay. Histological analysis revealed dense infiltration of CD8+ T cells in some lesions in patients who had received the SVN-2B peptide vaccine. A high rate of programmed cell death ligand 1 expression in cancer cells was observed in these cases, indicating that CTLs were induced by SVN-2B peptide vaccination and had infiltrated the lesions. The lack of a significant antitumor effect was most likely attributable to the expression of immune checkpoint molecules. These findings suggest that the combination of a tumor-specific peptide vaccine and an ICI might be a promising approach to the treatment of pancreatic carcinoma in the future.

DOI： 10.1111/cas.14099

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Randomized phase II trial of survivin 2B peptide vaccination for patients with HLA-A24-positive pancreatic adenocarcinoma

Hiroaki Shima, Giichiro Tsurita, Satoshi Wada, Yoshihiko Hirohashi, Hiroshi Yasui, Hiroshi Hayashi, Takashi Miyakoshi, Kazue Watanabe, Aiko Murai, Hiroko Asanuma, Serina Tokita, Terufumi Kubo, Munehide Nakatsugawa, Takayuki Kanaseki, Tomohide Tsukahara, Yutaka Nakae, Osamu Sugita, Yoichi M. Ito, Yasunori Ota, Yasutoshi Kimura, Goro Kutomi, Koichi Hirata, Toru Mizuguchi, Kohzoh Imai, Ichiro Takemasa, Noriyuki Sato, Toshihiko Torigoe

CANCER SCIENCE 110 ( 8 ) 2378 - 2385 2019.8

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DOI： 10.1111/cas.14106

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Scoring criteria for determining the safety of liver resection for malignant liver tumors Reviewed

Harada K, Nagayama M, Ohashi Y, Chiba A, Numasawa K, Meguro M, Kimura Y, Yamaguchi H, Kobayashi M, Miyanishi K, Kato J, Mizuguchi T

World J Meta-Anal 7 ( 5 ) 234 - 248 2019.5

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Language：English Publishing type：Research paper (scientific journal) Publisher：Baishideng Publishing Group Inc.

DOI： 10.13105/wjma.v7.i5.234

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Case report: Long-term survival of a pancreatic cancer patient immunized with an SVN-2B peptide vaccine. International journal

Hiroaki Shima, Goro Kutomi, Fukino Satomi, Masafumi Imamura, Yasutoshi Kimura, Toru Mizuguchi, Kazue Watanabe, Akari Takahashi, Aiko Murai, Tomohide Tsukahara, Takayuki Kanaseki, Yoshihiko Hirohashi, Yuji Iwayama, Tetsuhiro Tsuruma, Hidekazu Kameshima, Noriyuki Sato, Toshihiko Torigoe, Ichiro Takemasa

Cancer immunology, immunotherapy : CII 67 ( 10 ) 1603 - 1609 2018.10

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A 62-year-old woman who underwent surgery to treat pancreatic cancer provided written, informed consent to undergo adjuvant therapy with gemcitabine, tegafur, and uracil. However, this was stopped after only 14 days due to Grade 4 neutropenia. She was then started on vaccine therapy with Survivin 2B peptide (SVN-2B) including IFA and INF-α. Although metastatic lung tumors were identified and resected at 82 months after surgery, the patient has remained free of new or relapsed disease for 12 years thereafter. Tetramer and ELISPOT assays revealed the continuous circulation of SVN-2B-restricted cytotoxic T-lymphocytes (CTLs) in her peripheral blood, and CTL clones had specific activity for SVN-2B at 12 years after surgery. The adverse effects of the peptide vaccination were tolerable and comprised low-grade headache, nausea, and fatigue. A prognosis beyond 10 years in the face of pancreatic cancer with distant metastasis is extremely rare. This experience might indicate the value of cancer vaccination therapy.

DOI： 10.1007/s00262-018-2217-x

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外科医のための癌免疫療法進行膵臓がんを対象とした複合型CTLワクチン療法第2相試験

水口徹, 島宏彰, 九冨五郎, 木村康利, 竹政伊知朗, 鳥越俊彦, 廣橋良彦, 塚原智英, 金関貴幸, 釣田義一郎, 安井寛, 和田聡, 林宏至, 宮腰崇

日本臨床外科学会雑誌 78 ( 増刊 ) 419 - 419 2017.10

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Transplantation of Thy1(+) Cells Accelerates Liver Regeneration by Enhancing the Growth of Small Hepatocyte-Like Progenitor Cells via IL17RB Signaling Reviewed

Norihisa Ichinohe, Masayuki Ishii, Naoki Tanimizu, Junko Kon, Yusuke Yoshioka, Takahiro Ochiya, Toru Mizuguchi, Koichi Hirata, Toshihiro Mitaka

STEM CELLS 35 ( 4 ) 920 - 931 2017.4

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DOI： 10.1002/stem.2548

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Hepatocytic parental progenitor cells of rat small hepatocytes maintain self-renewal capability after long-term culture Reviewed

Masayuki Ishii, Junichi Kino, Norihisa Ichinohe, Naoki Tanimizu, Takafumi Ninomiya, Hiromu Suzuki, Toru Mizuguchi, Koichi Hirata, Toshihiro Mitaka

SCIENTIFIC REPORTS 7 46177 2017.4

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DOI： 10.1038/srep46177

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ST6GALNAC1 plays important roles in enhancing cancer stem phenotypes of colorectal cancer via the Akt pathway Reviewed

Tadashi Ogawa, Yoshihiko Hirohashi, Aiko Murai, Toshihiko Nishidate, Kenji Okita, Liming Wang, Yuzuru Ikehara, Tetsuta Satoyoshi, Akihiro Usui, Terufumi Kubo, Munehide Nakastugawa, Takayuki Kanaseki, Tomohide Tsukahara, Goro Kutomi, Tomohisa Furuhata, Koichi Hirata, Noriyuki Sato, Toru Mizuguchi, Ichiro Takemasa, Toshihiko Torigoe

Oncotarget 8 ( 68 ) 112550 - 112564 2017

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DOI： 10.18632/oncotarget.22545

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Flap revascularization in patients following immediate reconstruction using an autologous free dermal fat graft for breast cancer: a report of two cases. International journal

Hiroaki Shima, Goro Kutomi, Takuro Kyuno, Fukino Satomi, Satoko Uno, Hideki Maeda, Hidekazu Kameshima, Tosei Omura, Yasutoshi Kimura, Toru Mizuguchi, Koichi Hirata, Ichiro Takemasa

Surgical case reports 2 ( 1 ) 54 - 54 2016.12

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It has been reported that use of the free dermal fat graft (FDFG) technique produces a good cosmetic outcome for breast cancer. An FDFG is harvested from the lower abdomen as a columnar-shaped specimen and implanted into the defect of the breast after a partial mastectomy as a volume replacement technique. In this report, two patients who underwent breast-conserving surgery with immediate reconstruction using an autologous FDFG are described in order to show the difference in status between one case with and one without blood flow in the graft. To assess the benefit of this technique using FDFGs, their cosmetic satisfaction was evaluated using a questionnaire, graft shrinkage was measured by CT, and blood flow was assessed using contrast-enhanced ultrasound (CEUS). Both patients scored 10 of 12 points on the questionnaire. After 2 years, shrinkage of the grafts was 21.6 and 25.2 %, respectively. Although one patient had no blood flow in the center of the graft, the other had blood flow from the pectoralis major muscle to the center of the graft. While satisfaction and graft shrinkage were similar in the two patients, one case showed blood flow and had a somewhat softer graft than the other. The graft status was maintained with a good cosmetic outcome for 3 years after breast-conserving surgery with immediate reconstruction using an autologous FDFG, despite mild shrinkage and hardness of the graft. It is notable that blood flow was observed into the graft on CEUS, and more distinct perfusion was seen in the softer graft case after more than 3 years.

DOI： 10.1186/s40792-016-0181-2

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Liver Progenitors Isolated from Adult Healthy Mouse Liver Efficiently Differentiate to Functional Hepatocytes In Vitro and Repopulate Liver Tissue Reviewed

Naoki Tanimizu, Norihisa Ichinohe, Masayuki Ishii, Junichi Kino, Toru Mizuguchi, Koichi Hirata, Toshihiro Mitaka

STEM CELLS 34 ( 12 ) 2889 - 2901 2016.12

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DOI： 10.1002/stem.2457

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Involvement of Pancreatic Stellate Cells in Regeneration of Remnant Pancreas after Partial Pancreatectomy Reviewed

Shigenori Ota, Miyuki Nishimura, Yuya Murakami, Naoko Kubo Birukawa, Akihiro Yoneda, Hiroki Nishita, Ryosuke Fujita, Yasushi Sato, Kenjiro Minomi, Keiko Kajiwara, Miyono Miyazaki, Maki Uchiumi, Shintaro Mikuni, Yasuaki Tamura, Toru Mizuguchi, Masafumi Imamura, Makoto Meguro, Yasutoshi Kimura, Koichi Hirata, Yoshiro Niitsu

PLOS ONE 11 ( 12 ) e0165747 2016.12

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DOI： 10.1371/journal.pone.0165747

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Olfactory Receptor Family 7 Subfamily C Member 1 Is a Novel Marker of Colon Cancer-Initiating Cells and Is a Potent Target of Immunotherapy. International journal

Rena Morita, Yoshihiko Hirohashi, Toshihiko Torigoe, Satoko Ito-Inoda, Akari Takahashi, Tasuku Mariya, Hiroko Asanuma, Yasuaki Tamura, Tomohide Tsukahara, Takayuki Kanaseki, Terufumi Kubo, Goro Kutomi, Toru Mizuguchi, Takeshi Terui, Kunihiko Ishitani, Satoshi Hashino, Toru Kondo, Nozomi Minagawa, Norihiko Takahashi, Akinobu Taketomi, Satoru Todo, Masahiro Asaka, Noriyuki Sato

Clinical cancer research : an official journal of the American Association for Cancer Research 22 ( 13 ) 3298 - 309 2016.7

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PURPOSE: Cancer-initiating cells (CICs) are thought to be essential for tumor maintenance, recurrence, and distant metastasis, and they are therefore reasonable targets for cancer therapy. Cancer immunotherapy is a novel approach to target cancer. In this study, we aimed to establish novel CIC-targeting immunotherapy. EXPERIMENTAL DESIGN: Colorectal cancer (CRC) CICs were isolated as side population (SP) cells. The gene expression profile of CRC CICs was analyzed by cDNA microarray and RT-PCR. Protein expression of olfactory receptor family 7 subfamily C member 1 (OR7C1) were analyzed by Western blot and immunohistochemical staining. The functions of OR7C1 were analyzed by gene overexpression and gene knockdown using siRNAs. OR7C1-positive cells were isolated by a flow cytometer and analyzed. CTLs specific for OR7C1 peptide were generated, and the antitumor effect was addressed by mice adoptive transfer model. RESULTS: OR7C1 has essential roles in the maintenance of colon CICs, and the OR7C1-positive population showed higher tumorigenicity than that of the OR7C1-negative population, indicating that OR7C1 is a novel functional marker for colon CIC. Immunohistochemical staining revealed that OR7C1 high expression was correlated with poorer prognosis in CRC patients. OR7C1-derived antigenic peptide-specific CTLs showed specific cytotoxicity for CICs, and an OR7C1-specific CTL clone showed a greater antitumor effect than did a CTL clone targeting all cancer cells in a CTL adoptive transfer mouse model. CONCLUSIONS: OR7C1 is a novel marker for colon CICs and can be a target of potent CIC-targeting immunotherapy. Clin Cancer Res; 22(13); 3298-309. ©2016 AACR.

DOI： 10.1158/1078-0432.CCR-15-1709

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Intrahepatic Bile Ducts Are Developed Through Formation of Homogeneous Continuous Luminal Network and Its Dynamic Rearrangement in Mice Reviewed

Naoki Tanimizu, Kota Kaneko, Tohru Itoh, Norihisa Ichinohe, Masayuki Ishii, Toru Mizuguchi, Koichi Hirata, Atsushi Miyajima, Toshihiro Mitaka

HEPATOLOGY 64 ( 1 ) 175 - 188 2016.7

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DOI： 10.1002/hep.28521

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Pancreatic regeneration: basic research and gene regulation Reviewed

Kenji Okita, Toru Mizuguchi, Ota Shigenori, Masayuki Ishii, Toshihiko Nishidate, Tomomi Ueki, Makoto Meguro, Yasutoshi Kimura, Naoki Tanimizu, Norihisa Ichinohe, Toshihiko Torigoe, Takashi Kojima, Toshihiro Mitaka, Noriyuki Sato, Norimasa Sawada, Koichi Hirata

SURGERY TODAY 46 ( 6 ) 633 - 640 2016.6

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DOI： 10.1007/s00595-015-1215-2

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Multiple hepatocellular adenomas: A case report

Fumito Tamura, Yutaka Kawano, Koji Miyanishi, Tomohiro Kubo, Yusuke Kamihara, Yutaka Okagawa, Kazuma Ishikawa, Kohichi Takada, Tsuyoshi Hayashi, Tsutomu Sato, Yasushi Sato, Masayoshi Kobune, Rishu Takimoto, Masaki Kawamoto, Makoto Meguro, Toru Mizuguchi, Ziro Ogino, Tadashi Hasegawa, Norihide Yoneda, Motoko Sasaki, Junji Kato

Acta Hepatologica Japonica 56 ( 11 ) 584 - 595 2015.12

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Language：Japanese Publishing type：Research paper (scientific journal) Publisher：Japan Society of Hepatology

DOI： 10.2957/kanzo.56.584

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Surgical and oncological impact of main pancreatic duct spread in invasive ductal adenocarcinoma: A clinicopathological study of 184 resected cases Reviewed

Masayuki Ishii, Yasutoshi Kimura, Shintaro Sugita, Masafumi Imamura, Tatsuya Ito, Takayuki Nobuoka, Makoto Meguro, Tadashi Hasegawa, Toru Mizuguchi, Koichi Hirata

PANCREATOLOGY 15 ( 6 ) 681 - 687 2015.11

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DOI： 10.1016/j.pan.2015.09.017

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Long-term and perioperative outcomes of laparoscopic versus open liver resection for colorectal liver metastases with propensity score matching: a multi-institutional Japanese study Reviewed

Toru Beppu, Go Wakabayashi, Kiyoshi Hasegawa, Naoto Gotohda, Toru Mizuguchi, Yutaka Takahashi, Fumitoshi Hirokawa, Nobuhiko Taniai, Manabu Watanabe, Masato Katou, Hiroaki Nagano, Goro Honda, Hideo Baba, Norihiro Kokudo, Masaru Konishi, Koichi Hirata, Masakazu Yamamoto, Kazuhisa Uchiyama, Eiji Uchida, Shinya Kusachi, Keiichi Kubota, Masaki Mori, Keiichi Takahashi, Ken Kikuchi, Hiroaki Miyata, Takeshi Takahara, Masafumi Nakamura, Hironori Kaneko, Hiroki Yamaue, Masaru Miyazaki, Tadahiro Takada

JOURNAL OF HEPATO-BILIARY-PANCREATIC SCIENCES 22 ( 10 ) 711 - 720 2015.10

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DOI： 10.1002/jhbp.261

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バイオマーカーをめぐるQ&A(Question 16) hERO1-Lα発現による乳癌予後予測は可能か?

九冨五郎, 久木田和晴, 里見蕗乃, 前田豪樹, 島宏彰, 水口徹, 平田公一

Surgery Frontier 22 ( 3 ) 283 - 285 2015.9

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Clinical comparison of laparoscopic and open liver resection after propensity matching selection Reviewed

Makoto Meguro, Toru Mizuguchi, Masaki Kawamoto, Shigenori Ota, Masayuki Ishii, Toshihiko Nishidate, Kenji Okita, Yasutoshi Kimura, Koichi Hirata

SURGERY 158 ( 3 ) 573 - 587 2015.9

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DOI： 10.1016/j.surg.2015.02.031

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Effects of antecolic versus retrocolic reconstruction for gastro/duodenojejunostomy on delayed gastric emptying after pancreatoduodenectomy: A systematic review and meta-analysis

Masafumi Imamura, Yasutoshi Kimura, Tatsuya Ito, Takuro Kyuno, Takayuki Nobuoka, Toru Mizuguchi, Koichi Hirata

Journal of Surgical Research 200 ( 1 ) 147 - 157 2015.5

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DOI： 10.1016/j.jss.2015.08.004

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Prognostic roles of preoperative α-fetoprotein and des-γ-carboxy prothrombin in hepatocellular carcinoma patients

Makoto Meguro, Toru Mizuguchi, Toshihiko Nishidate, Kenji Okita, Masayuki Ishii, Shigenori Ota, Tomomi Ueki, Emi Akizuki, Koichi Hirata

World Journal of Gastroenterology 21 ( 16 ) 4933 - 4945 2015.4

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DOI： 10.3748/wjg.v21.i16.4933

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A dose-escalation study of oxaliplatin/capecitabine/irinotecan (XELOXIRI) and bevacizumab as a first-line therapy for patients with metastatic colorectal cancer Reviewed

Yasushi Sato, Hiroyuki Ohnuma, Masahiro Hirakawa, Minoru Takahashi, Takahiro Osuga, Yutaka Okagawa, Kazuyuki Murase, Kohichi Takada, Yutaka Kawano, Satoshi Iyama, Tsuyoshi Hayashi, Tsutomu Sato, Koji Miyanishi, Rishu Takimoto, Masayoshi Kobune, Kenji Okita, Toru Mizuguchi, Tomohisa Furuhata, Koichi Hirata, Junji Kato

CANCER CHEMOTHERAPY AND PHARMACOLOGY 75 ( 3 ) 587 - 594 2015.3

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DOI： 10.1007/s00280-014-2672-9

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An immunohistochemical marker panel including claudin-18, maspin, and p53 improves diagnostic accuracy of bile duct neoplasms in surgical and presurgical biopsy specimens. International journal

Yoshiko Keira, Akira Takasawa, Masaki Murata, Masanori Nojima, Kumi Takasawa, Jiro Ogino, Yukimura Higashiura, Ayaka Sasaki, Yasutoshi Kimura, Toru Mizuguchi, Satoshi Tanaka, Koichi Hirata, Norimasa Sawada, Tadashi Hasegawa

Virchows Archiv : an international journal of pathology 466 ( 3 ) 265 - 77 2015.3

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Biliary tract cancers have an extremely poor outcome, and specific diagnostic markers and effective treatments are needed urgently. In this study, we assessed the capacity of panel of immunohistochemical markers including claudin-18, maspin, and p53 to distinguish biliary tract carcinoma and biliary intraepithelial neoplasia (BilIN) from non-neoplastic epithelium. We performed a retrospective study of 66 biliary tract cancer specimens and 63 specimens with non-neoplastic lesions. Of the surgical specimens, 96.7 % with adenocarcinoma/BilIN were detected as neoplastic, and all 63 specimens histologically diagnosed as non-neoplastic lesion were detected as non-neoplastic with high sensitivity (91.1 %) and specificity (100 %). Of presurgical endobiliary forceps biopsy specimens, all with adenocarcinoma/BilIN and only 1 of the 19 with a non-neoplastic lesion were distinguished as neoplastic with high sensitivity (100 %) and specificity (94.7 %). Moreover, this panel provided good separation of neoplasm from malignancy-undetermined atypical epithelium (18/21, 85.7 %). This panel achieves a more reliable distinction of biliary tract cancers and BilINs from non-neoplastic epithelia in both surgical and biopsy specimens than immunohistochemical analysis with single antibodies and is useful in supporting a diagnosis of adenocarcinoma and BilIN.

DOI： 10.1007/s00428-014-1705-4

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Clinical feasibility of laparoscopic lateral pelvic lymph node dissection following total mesorectal excision for advanced rectal cancer Reviewed

Tomohisa Furuhata, Kenji Okita, Toshihiko Nishidate, Tatsuya Ito, Hiroshi Yamaguchi, Tomomi Ueki, Emi Akizuki, Makoto Meguro, Tadashi Ogawa, Kazuharu Kukita, Yasutoshi Kimura, Toru Mizuguchi, Koichi Hirata

SURGERY TODAY 45 ( 3 ) 310 - 314 2015.3

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DOI： 10.1007/s00595-014-0906-4

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New technique of extracorporeal hepatic inflow control for pure laparoscopic liver resection

Toru Mizuguchi, Masaki Kawamoto, Yukio Nakamura, Makoto Meguro, Thomas T. Hui, Koichi Hirata

Surgical Laparoscopy, Endoscopy and Percutaneous Techniques 25 ( 1 ) e16 - e20 2015.2

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Language：English Publishing type：Research paper (scientific journal) Publisher：Lippincott Williams and Wilkins

DOI： 10.1097/SLE.0b013e3182a4c0f4

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Prognostic value of HLA class I expression in patients with colorectal cancer Reviewed

Yuji Iwayama, Tetsuhiro Tsuruma, Toru Mizuguchi, Tomohisa Furuhata, Nobuhiko Toyota, Masayuki Matsumura, Toshihiko Torigoe, Noriyuki Sato, Koichi Hirata

WORLD JOURNAL OF SURGICAL ONCOLOGY 13 2015.2

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DOI： 10.1186/s12957-015-0456-2

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Remnant Pancreas Reconstruction with Duct-To-Duct Anastomosis after Middle Pancreatectomy: A Report of Two Cases Reviewed

Masayuki Ishii, Yasutoshi Kimura, Masafumi Imamura, Daisuke Kyuno, Tomomi Ueki, Motonobu Uchiyama, Toru Mizuguchi, Mitsuhiro Mukaiya, Koichi Hirata

HEPATO-GASTROENTEROLOGY 62 ( 137 ) 190 - 194 2015.1

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DOI： 10.5754/hge14568

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Soluble Lutheran/basal cell adhesion molecule is detectable in plasma of hepatocellular carcinoma patients and modulates cellular interaction with laminin-511 in vitro

Yamato Kikkawa, Takahiro Miwa, Naoki Tanimizu, Yuichi Kadoya, Takaho Ogawa, Fumihiko Katagiri, Kentaro Hozumi, Motoyoshi Nomizu, Toru Mizuguchi, Koichi Hirata, Toshihiro Mitaka

Experimental Cell Research 328 ( 1 ) 197 - 206 2014.10

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DOI： 10.1016/j.yexcr.2014.07.012

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プロペンシティ解析を用いた膵頭十二指腸切除術後アウトカムの比較研究

安田尚美, 木村康利, 今村将史, 伊東竜哉, 沖田憲司, 水口徹, 古畑智久, 平田公一

日本臨床外科学会雑誌 75 ( 9 ) 2643 - 2643 2014.9

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Saline Injection Method for Facilitating the Liver Hanging Maneuver During Hepatectomy for a Large Right Liver Tumor Reviewed

Toru Mizuguchi, Masaki Kawamoto, Makoto Meguro, Kenji Okita, Toshihiko Nishidate, Tomohisa Furuhata, Thomas T. Hui, Koichi Hirata

JOURNAL OF THE AMERICAN COLLEGE OF SURGEONS 219 ( 2 ) E11 - E14 2014.8

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DOI： 10.1016/j.jamcollsurg.2014.01.065

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Highest intraoperative lactate level could predict postoperative infectious complications after hepatectomy, reflecting the Pringle maneuver especially in chronic liver disease Reviewed

Makoto Meguro, Toru Mizuguchi, Masaki Kawamoto, Toshihiko Nishidate, Masayuki Ishii, Hiroomi Tatsumi, Yasutoshi Kimura, Tomohisa Furuhata, Koichi Hirata

JOURNAL OF HEPATO-BILIARY-PANCREATIC SCIENCES 21 ( 7 ) 489 - 498 2014.7

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DOI： 10.1002/jhbp.87

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Preoperative hepatocyte transplantation improves the survival of rats with nonalcoholic steatohepatitis-related cirrhosis after partial hepatectomy

Yukio Nakamura, Toru Mizuguchi, Naoki Tanimizu, Norihisa Ichinohe, Hidekazu Ooe, Masaki Kawamoto, Makoto Meguro, Koichi Hirata, Toshihiro Mitaka

Cell Transplantation 23 ( 10 ) 1243 - 1254 2014

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DOI： 10.3727/096368913X668645

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Propensity score analysis demonstrated the prognostic advantage of anatomical liver resection in hepatocellular carcinoma

Masayuki Ishii, Toru Mizuguchi, Masaki Kawamoto, Makoto Meguro, Shigenori Ota, Toshihiko Nishidate, Kenji Okita, Yasutohsi Kimura, Thomas T. Hui, Koichi Hirata

World Journal of Gastroenterology 20 ( 12 ) 3335 - 3342 2014

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DOI： 10.3748/wjg.v20.i12.3335

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Pancreaticoduodenectomy for biliary tract carcinoma with situs inversus totalis: difficulties and technical notes based on two cases. Reviewed International journal

Daisuke Kyuno, Yasutoshi Kimura, Masafumi Imamura, Motonobu Uchiyama, Masayuki Ishii, Makoto Meguro, Masaki Kawamoto, Toru Mizuguchi, Koichi Hirata

World journal of surgical oncology 11 312 - 312 2013.12

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DOI： 10.1186/1477-7819-11-312

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腹腔鏡補助下腹会陰式直腸切断術後の会陰ヘルニアの1例

及能拓朗, 古畑智久, 植木知身, 沖田憲司, 秋月恵美, 川本雅樹, 西舘敏彦, 目黒誠, 信岡隆幸, 木村康利, 水口徹, 平田公一, 久木田和晴

北海道外科雑誌 58 ( 2 ) 177 - 178 2013.12

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Hepatic biliary epithelial cells acquire epithelial integrity but lose plasticity to differentiate into hepatocytes in vitro during development Reviewed

Naoki Tanimizu, Yukio Nakamura, Norihisa Ichinohe, Toru Mizuguchi, Koichi Hirata, Toshihiro Mitaka

JOURNAL OF CELL SCIENCE 126 ( 22 ) 5239 - + 2013.11

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DOI： 10.1242/jcs.133082

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大腸癌転移性肝転移の術前化学療法症例の検討

西舘敏彦, 古畑智久, 沖田憲司, 植木知身, 秋月恵美, 久木田和晴, 小川宰司, 目黒誠, 川本雅樹, 信岡隆幸, 木村康利, 水口徹, 秦史壮, 佐々木一晃, 平田公一

日本消化器外科学会雑誌 46 ( Suppl.2 ) 250 - 250 2013.10

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Continuous monitoring of central venous oxygen saturation predicts postoperative liver dysfunction after liver resection Reviewed

Makoto Meguro, Toru Mizuguchi, Masaki Kawamoto, Yukio Nakamura, Shigenori Ota, Kazuharu Kukita, Masayuki Ishii, Hiroomi Tatsumi, Koichi Hirata

SURGERY 154 ( 2 ) 351 - 362 2013.8

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DOI： 10.1016/j.surg.2013.04.039

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下部直腸癌における腹腔鏡下側方リンパ節郭清術

古畑智久, 沖田憲司, 西舘敏彦, 植木知身, 秋月恵美, 久木田和晴, 信岡隆幸, 木村康利, 水口徹, 平田公一

日本消化器外科学会総会 68回 RV - 1 2013.7

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Asialoglycoprotein receptor scintigraphy with Tc-99m-galactosyl human serum albumin (Tc-99m-GSA) as an early predictor of survival in acute liver failure Reviewed

H. Tatsumi, Y. Masuda, H. Imaizumi, S. Yoshida, K. Goto, N. Yama, T. Mizuguchi, K. Hirata

ANAESTHESIA AND INTENSIVE CARE 41 ( 4 ) 523 - 528 2013.7

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Prognosis and Predictors of Surgical Complications in Hepatocellular Carcinoma Patients With or Without Cirrhosis after Hepatectomy Reviewed

Toru Mizuguchi, Masaki Kawamoto, Makoto Meguro, Yukio Nakamura, Shigenori Ota, Thomas T. Hui, Koichi Hirata

WORLD JOURNAL OF SURGERY 37 ( 6 ) 1379 - 1387 2013.6

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DOI： 10.1007/s00268-013-1989-6

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Differentiation capacity of hepatic stem/progenitor cells isolated from D-galactosamine-treated rat livers. International journal

Norihisa Ichinohe, Naoki Tanimizu, Hidekazu Ooe, Yukio Nakamura, Toru Mizuguchi, Junko Kon, Koichi Hirata, Toshihiro Mitaka

Hepatology (Baltimore, Md.) 57 ( 3 ) 1192 - 202 2013.3

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UNLABELLED: Oval cells and small hepatocytes (SHs) are known to be hepatic stem and progenitor cells. Although oval cells are believed to differentiate into mature hepatocytes (MHs) through SHs, the details of their differentiation process are not well understood. Furthermore, it is not certain whether the induced cells possess fully mature functions as MHs. In the present experiment, we used Thy1 and CD44 to isolate oval and progenitor cells, respectively, from D-galactosamine-treated rat livers. Epidermal growth factor, basic fibroblast growth factor, or hepatocyte growth factor could trigger the hepatocytic differentiation of sorted Thy1(+) cells to form epithelial cell colonies, and the combination of the factors stimulated the emergence and expansion of the colonies. Cells in the Thy1(+) -derived colonies grew more slowly than those in the CD44(+) -derived ones in vitro and in vivo and the degree of their hepatocytic differentiation increased with CD44 expression. Although the induced hepatocytes derived from Thy1(+) and CD44(+) cells showed similar morphology to MHs and formed organoids from the colonies similar to those from SHs, many hepatic differentiated functions of the induced hepatocytes were less well performed than those of mature SHs derived from the healthy liver. The gene expression of cytochrome P450 1A2, tryptophan 2,3-dioxygenase, and carbamoylphosphate synthetase I was lower in the induced hepatocytes than in mature SHs. In addition, the protein expression of CCAAT/enhancer-binding protein alpha and bile canalicular formation could not reach the levels of production of mature SHs. CONCLUSION: The results suggest that, although Thy1(+) and CD44(+) cells are able to differentiate into hepatocytes, the degree of maturation of the induced hepatocytes may not be equal to that of healthy resident hepatocytes. (HEPATOLOGY 2013).

DOI： 10.1002/hep.26084

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Soluble form of luthern/B-CAM in plasma as a potential maker for hepatocellular carcinoma Reviewed

Kikkawa Yamato, Tanimizu Naoki, Miwa Takahiro, Mizuguchi Toru, Hirata Koichi, Nomizu Motoyoshi, Mitaka Toshihiro

GLYCOBIOLOGY 22 ( 11 ) 1601 2012.11

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Area between the hepatic and heart curves of Tc-99m-galactosyl-human serum albumin scintigraphy represents liver function and disease progression for preoperative evaluation in hepatocellular carcinoma patients Reviewed

Kohei Harada, Toru Mizuguchi, Yoshimi Katagiri, Masaki Kawamoto, Yukio Nakamura, Makoto Meguro, Shigenori Ota, Shigeru Sasaki, Koji Miyanishi, Tomoko Sonoda, Mitsuru Mori, Yasuhisa Shinomura, Junji Kato, Koichi Hirata

JOURNAL OF HEPATO-BILIARY-PANCREATIC SCIENCES 19 ( 6 ) 667 - 673 2012.11

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DOI： 10.1007/s00534-011-0486-2

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Serum Antithrombin III Level is Well Correlated with Multiple Indicators for Assessment of Liver Function and Diagnostic Accuracy for Predicting Postoperative Liver Failure in Hepatocellular Carcinoma Patients Reviewed

Toru Mizuguchi, Masaki Kawamoto, Makoto Meguro, Seiichi Son, Yukio Nakamura, Kohei Harada, Toshihito Shibata, Shigenori Ota, Koichi Hirata

HEPATO-GASTROENTEROLOGY 59 ( 114 ) 551 - 557 2012.3

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DOI： 10.5754/hge10052

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【Oncologic emergency】胆道閉塞

孫誠一, 木村康利, 今村将史, 今野愛, 鶴間哲弘, 目黒誠, 水口徹, 平田公一

消化器外科 35 ( 3 ) 301 - 309 2012.3

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Low-dose steroid pretreatment ameliorates the transient impairment of liver regeneration Reviewed

Toshihito Shibata, Toru Mizuguchi, Yukio Nakamura, Masaki Kawamoto, Makoto Meguro, Shigenori Ota, Koichi Hirata, Hidekazu Ooe, Toshihiro Mitaka

WORLD JOURNAL OF GASTROENTEROLOGY 18 ( 9 ) 905 - 914 2012.3

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DOI： 10.3748/wjg.v18.i9.905

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Vascular endothelial growth factor 165b expression in stromal cells and colorectal cancer Reviewed

Makoto Tayama, Tomohisa Furuhata, Yoshiko Inafuku, Kenji Okita, Toshihiko Nishidate, Toru Mizuguchi, Yasutoshi Kimura, Koichi Hirata

WORLD JOURNAL OF GASTROENTEROLOGY 17 ( 44 ) 4867 - 4874 2011.11

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DOI： 10.3748/wjg.v17.i44.4867

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Prognostic Impact of Preoperative the Branched-Chain Amino Acid to the Tyrosine Ratio in Hepatocellular Carcinoma Patients after Initial Hepatectomy Reviewed

Toru Mizuguchi, Masaki Kawamoto, Makoto Meguro, Yukio Nakamura, Kohei Harada, Kazuharu Kukita, Koichi Hirata

JOURNAL OF GASTROINTESTINAL SURGERY 15 ( 8 ) 1433 - 1439 2011.8

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DOI： 10.1007/s11605-011-1566-y

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Cluster analysis of indicators of liver functional and preoperative low branched-chain amino acid tyrosine ration indicate a high risk of early recurrence in analysis of 165 hepatocellular carcinoma patients after initial hepatectomy Reviewed

Yukio Nakamura, Toru Mizuguchi, Masaki Kawamoto, Makoto Meguro, Kohei Harada, Shigenori Ota, Koichi Hirata

SURGERY 150 ( 2 ) 250 - 262 2011.8

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DOI： 10.1016/j.surg.2011.06.001

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フォンダパリヌクスナトリウム使用による下部消化管手術後の静脈血栓塞栓症予防対策

山口洋志, 古畑智久, 久木田和晴, 西舘敏彦, 沖田憲司, 信岡隆幸, 木村康利, 水口徹, 平田公一

日本消化器外科学会総会 66回 546 - 546 2011.7

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【肝・胆・膵外科における感染症に対する治療戦略】肝切除術創部管理に関する検討真皮埋没縫合と皮下持続吸引ドレナージの有用性について

川本雅樹, 水口徹, 目黒誠, 久木田和晴, 中村幸雄, 信岡隆幸, 木村康利, 古畑智久, 平田公一

日本外科感染症学会雑誌 8 ( 1 ) 21 - 25 2011.2

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Other Link： https://search.jamas.or.jp/default/link?pub_year=2011&ichushi_jid=J04188&link_issn=&doc_id=20110324440004&doc_link_id=%2Fdg9srgif%2F2011%2F000801%2F005%2F0021-0025%26dl%3D0&url=https%3A%2F%2Fwww.medicalonline.jp%2Fjamas.php%3FGoodsID%3D%2Fdg9srgif%2F2011%2F000801%2F005%2F0021-0025%26dl%3D0&type=MedicalOnline&icon=https%3A%2F%2Fjk04.jamas.or.jp%2Ficon%2F00004_2.gif

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当科での下部消化管手術におけるフォンダパリヌクスナトリウムの使用経験

山口洋志, 古畑智久, 久木田和晴, 西舘敏彦, 沖田憲司, 信岡隆幸, 木村康利, 水口徹, 平田公一

日本大腸肛門病学会雑誌 64 ( 2 ) 102 - 102 2011.2

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ローカルSSIサーベイランス2007 最新の報告を10年分と比較して

水口徹, 川本雅樹, 目黒誠, 久木田和晴, 中村幸雄, 木村康利, 信岡隆幸, 古畑智久, 平田公一

日本外科感染症学会雑誌 7 ( 6 ) 589 - 594 2010.12

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Other Link： https://search.jamas.or.jp/default/link?pub_year=2010&ichushi_jid=J04188&link_issn=&doc_id=20110113580002&doc_link_id=%2Fdg9srgif%2F2010%2F000706%2F002%2F0589-0594%26dl%3D0&url=https%3A%2F%2Fwww.medicalonline.jp%2Fjamas.php%3FGoodsID%3D%2Fdg9srgif%2F2010%2F000706%2F002%2F0589-0594%26dl%3D0&type=MedicalOnline&icon=https%3A%2F%2Fjk04.jamas.or.jp%2Ficon%2F00004_2.gif

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当科における腹腔鏡補助下肝切除術出血量の抑制と手術時間の短縮を目指して

川本雅樹, 水口徹, 目黒誠, 久木田和晴, 永山稔, 信岡隆幸, 木村康利, 古畑智久, 平田公一

日本消化器外科学会総会 65回 81 - 81 2010.7

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大腸癌における血清抗p53抗体測定の有用性に関する検討

久木田和晴, 古畑智久, 沖田憲司, 西舘敏彦, 信岡隆幸, 木村康利, 水口徹, 秦史壮, 佐々木一晃, 平田公一

日本消化器外科学会総会 65回 491 - 491 2010.7

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原発巣切除versus非切除根治切除不能Stage IV大腸癌に対する治療方針

古畑智久, 沖田憲司, 西舘敏彦, 久木田和晴, 山口洋志, 木村康利, 水口徹, 平田公一

北海道外科雑誌 55 ( 1 ) 12 - 16 2010.6

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直腸周囲膿瘍で発症し門脈気腫を認めた直腸GISTの1例

久木田和晴, 古畑智久, 沖田憲司, 西舘敏彦, 信岡隆幸, 木村康利, 水口徹, 平田公一

北海道外科雑誌 55 ( 1 ) 65 - 65 2010.6

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腹腔鏡(補助)下肝切除術における肝離断方法の工夫症例によるdeviceの選択

川本雅樹, 水口徹, 目黒誠, 久木田和晴, 永山稔, 信岡隆幸, 木村康利, 古畑智久, 平田公一

日本肝胆膵外科学会・学術集会プログラム・抄録集 22回 262 - 262 2010.5

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イレウスに対する診断と外科治療下部大腸癌イレウスに対する治療戦略

沖田憲司, 古畑智久, 西舘敏彦, 久木田和晴, 原田敬介, 川本雅樹, 今村将史, 目黒誠, 永山稔, 信岡隆幸, 木村康利, 水口徹, 秦史壮, 佐々木一晃, 平田公一

日本外科系連合学会誌 35 ( 3 ) 452 - 452 2010.5

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完全腹腔鏡下外側区域部分切除術を施行した一例

庄司哲明, 水口徹, 川本雅樹, 目黒誠, 久木田和晴, 永山稔, 信岡隆幸, 木村康利, 古畑智久, 平田公一

日本臨床外科学会雑誌 71 ( 5 ) 1375 - 1375 2010.5

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肝細胞癌患者における分枝鎖アミノ酸/チロシンモル比(BTR)値の術前肝機能評価および予後予測因子としての有用性に関する検討

久木田和晴, 水口徹, 川本雅樹, 目黒誠, 中村幸雄, 信岡隆幸, 木村康利, 古畑智久, 平田公一

日本外科学会雑誌 111 ( 臨増2 ) 729 - 729 2010.3

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肝硬変ラットモデルにおける肝細胞移植の肝機能改善効果についての検討

中村幸雄, 水口徹, 目黒誠, 川本雅樹, 柴田稔人, 久木田和晴, 古畑智久, 木村康利, 信岡隆幸, 平田公一, 三高俊広

日本外科学会雑誌 111 ( 臨増2 ) 526 - 526 2010.3

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当科における腹腔鏡補助下肝切除術

久木田和晴, 水口徹, 川本雅樹, 目黒誠, 永山稔, 信岡隆幸, 木村康利, 古畑智久, 平田公一, 孫誠一

日本臨床外科学会雑誌 71 ( 3 ) 869 - 870 2010.3

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肝機能指標としてのATIIIの有用性とICGとの相関性と互換性に関する検討

水口徹, 川本雅樹, 目黒誠, 久木田和晴, 中村幸雄, 永山稔, 今村将史, 木村康利, 信岡隆幸, 古畑智久, 平田公一

日本外科学会雑誌 111 ( 臨増2 ) 729 - 729 2010.3

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進行直腸癌からの出血にたいして、緊急骨盤内臓全摘術を施行した1例

西舘敏彦, 古畑智久, 沖田憲司, 久木田和晴, 目黒誠, 原田敬介, 川本正樹, 今村将史, 永山稔, 信岡隆幸, 木村康利, 水口徹, 平田公一

日本腹部救急医学会雑誌 30 ( 2 ) 249 - 249 2010.2

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[Present status and future prospects of nutritional support teams].

Koichi Hirata, Kieko Kawasaki, Hiroomi Tatsumi, Toru Mizuguchi, Makoto Meguro, Itaru Hasegawa, Ken-ichi Sasaki, Eri Ishizaka, Ayumi Fujita, Takayuki Nobuoka

Nippon Geka Gakkai zasshi 111 ( 6 ) 341 - 347 2010

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当科における腹腔鏡(補助)下肝切除術の現状と標準化に向けて

目黒誠, 水口徹, 川本雅樹, 久木田和晴, 永山稔, 西舘敏彦, 沖田憲司, 信岡隆幸, 木村康利, 古畑智久, 平田公一

日本内視鏡外科学会雑誌 14 ( 7 ) 598 - 598 2009.12

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当科の肝切除術における創管理法の工夫と術後創感染の検討

目黒誠, 水口徹, 川本雅樹, 久木田和晴, 西舘敏彦, 沖田憲司, 永山稔, 信岡隆幸, 木村康利, 古畑智久, 平田公一

北海道外科雑誌 54 ( 2 ) 119 - 123 2009.12

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Effects of a low-fat meal on the oral bioavailability of UFT and leucovorin in patients with colorectal cancer

Tomohisa Furuhata, Makoto Meguro, Toshihiko Nishidate, Kenji Okita, Gentarou Ishiyama, Yuuji Iwayama, Yuuichi Hosokawa, Tetsuhiko Tsuruma, Yasutoshi Kimura, Toru Mizuguchi, Kazuaki Sasaki

International Journal of Clinical Oncology 14 ( 6 ) 529 - 533 2009.12

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DOI： 10.1007/s10147-009-0919-y

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当科における肝切除術における手術創およびドレーン管理

久木田和晴, 水口徹, 川本雅樹, 目黒誠, 永山稔, 信岡隆幸, 木村康利, 古畑智久, 平田公一

北海道外科雑誌 54 ( 2 ) 159 - 159 2009.12

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当科における肝切除術における手術創およびドレーン管理

川本雅樹, 水口徹, 久木田和晴, 目黒誠, 永山稔, 信岡隆幸, 木村康利, 古畑智久, 平田公一

日本外科感染症学会雑誌 6 ( 5 ) 528 - 528 2009.11

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ローカルサーベイランス2007 最新の報告を10年分と比較して

水口徹, 川本雅樹, 目黒誠, 久木田和晴, 永山稔, 今村将史, 木村康利, 信岡隆幸, 古畑智久, 平田公一

日本外科感染症学会雑誌 6 ( 5 ) 520 - 520 2009.11

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当科における腹腔鏡(補助)下肝切除術の工夫

目黒誠, 水口徹, 川本雅樹, 久木田和晴, 中村幸雄, 西舘敏彦, 沖田憲司, 永山稔, 信岡隆幸, 木村康利, 古畑智久, 平田公一

日本臨床外科学会雑誌 70 ( 増刊 ) 481 - 481 2009.10

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Clinical compliance with an oral uracil/tegafur (UFT) plus leucovorin (LV) regimen as adjuvant chemotherapy in Japanese colorectal cancer patients Reviewed

Makoto Meguro, Tomohisa Furuhata, Kenji Okita, Toshihiko Nishidate, Gentaro Ishiyama, Yuji Iwayama, Yasutoshi Kimura, Toru Mizuguchi, Koichi Hirata

INTERNATIONAL JOURNAL OF CLINICAL ONCOLOGY 14 ( 5 ) 402 - 407 2009.10

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DOI： 10.1007/s10147-009-0888-1

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当科における高齢者肝切除症例の検討

川本雅樹, 水口徹, 目黒誠, 久木田和晴, 孫誠一, 永山稔, 西舘敏彦, 沖田憲司, 今村将史, 信岡隆幸, 木村康利, 古畑智久, 平田公一

日本臨床外科学会雑誌 70 ( 増刊 ) 683 - 683 2009.10

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How I do it?肝切除ラウンドチップCUSAによる高度癒着剥離術と新規肝切離法

水口徹, 川本雅樹, 久木田和晴, 目黒誠, 木村康利, 古畑智久, 信岡隆幸, 平田公一

日本臨床外科学会雑誌 70 ( 増刊 ) 343 - 343 2009.10

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同時多発性に発症し異なった組織型を呈した混合型肝癌の1切除例

久木田和晴, 水口徹, 川本雅樹, 目黒誠, 孫誠一, 西舘敏彦, 原田敬介, 沖田憲司, 今村将史, 永山稔, 信岡隆幸, 木村康利, 古畑智久, 平田公一

日本臨床外科学会雑誌 70 ( 増刊 ) 680 - 680 2009.10

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Impaired liver regeneration with humoral and genetic disturbances in urinary trypsin inhibitor-deficient mice Reviewed

Takayuki Nobuoka, Toru Mizuguchi, Hideki Oshima, Toshihito Shibata, Shinsuke Kaji, Minoru Nagayama, Makoto Meguro, Toshihiro Mitaka, Koichi Hirata

LIVER INTERNATIONAL 29 ( 7 ) 979 - 987 2009.8

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DOI： 10.1111/j.1478-3231.2009.01990.x

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Matrix metalloproteinase-2 expression in stromal tissues is a consistent prognostic factor in stage II colon cancer Reviewed

Yoshiko Inafuku, Tomohisa Furuhata, Makoto Tayama, Kenji Okita, Toshihiko Nishidate, Toru Mizuguchi, Yasutoshi Kimura, Koichi Hirata

CANCER SCIENCE 100 ( 5 ) 852 - 858 2009.5

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DOI： 10.1111/j.1349-7006.2009.01116.x

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Prognostic Impact of Surgical Complications and Preoperative Serum Hepatocyte Growth Factor in Hepatocellular Carcinoma Patients After Initial Hepatectomy Reviewed

Toru Mizuguchi, Minoru Nagayama, Makoto Meguro, Toshihito Shibata, Shinsuke Kaji, Takayuki Nobuoka, Yasutoshi Kimura, Tomohisa Furuhata, Koichi Hirata

JOURNAL OF GASTROINTESTINAL SURGERY 13 ( 2 ) 325 - 333 2009.2

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DOI： 10.1007/s11605-008-0711-8

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Rapid recovery of postoperative liver function after major hepatectomy using saline-linked electric cautery

Toru Mizuguchi, Tadashi Katsuramaki, Minoru Nagayama, Makoto Meguro, Toshihito Shibata, Shinsuke Kaji, Koichi Hirata

Hepato-Gastroenterology 55 ( 88 ) 2188 - 2192 2008.11

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Laminin alpha 5 mediates ectopic adhesion of hepatocellular carcinoma through integrins and/or Lutheran/basal cell adhesion molecule Reviewed

Yamato Kikkawa, Ryo Sudo, Junko Kon, Toru Mizuquchi, Motoyoshi Nomizu, Koichi Hirata, Toshihiro Mitaka

EXPERIMENTAL CELL RESEARCH 314 ( 14 ) 2579 - 2590 2008.8

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DOI： 10.1016/j.yexcr.2008.05.021

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膵癌に対する膵頭十二指腸切除術の各種手術手技膵周囲剥離面陰性化を目指した神経叢郭清と門脈合併切除・再建

木村康利, 永山稔, 今野愛, 信岡隆幸, 今村将史, 水口徹, 古畑智久, 平田公一

日本消化器外科学会雑誌 41 ( 7 ) 1013 - 1013 2008.7

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Prospective nonrandomized comparison between pylorus-preserving and subtotal stomach-preserving pancreaticoduodenectomy from the perspectives of DGE occurrence and postoperative digestive functions

Emi Akizuki, Yasutoshi Kimura, Takayuki Nobuoka, Masafumi Imamura, Toshihiko Nishidate, Toru Mizuguchi, Tomohisa Furuhata, Koichi Hirata

Journal of Gastrointestinal Surgery 12 ( 7 ) 1185 - 1192 2008.7

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DOI： 10.1007/s11605-008-0513-z

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【膵切除術の術式選択と手術手技】膵頭部浸潤性膵管癌に対する外科治療

永山稔, 木村康利, 今野愛, 信岡隆幸, 水口徹, 古畑智久, 平田公一

消化器外科 31 ( 7 ) 1123 - 1131 2008.6

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膵と胆管で乳頭粘液性腫瘍が同時重複した一例

永山稔, 木村康利, 今野愛, 信岡隆幸, 古畑智久, 水口徹, 平田公一, 廣川直樹

膵臓 23 ( 3 ) 432 - 432 2008.6

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膵IPMCと胆管IPMNが並存した1例

永山稔, 木村康利, 今野愛, 信岡隆幸, 水口徹, 古畑智久, 平田公一

北海道外科雑誌 53 ( 1 ) 96 - 96 2008.6

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教室における小膵癌(ts1)症例の検討

木村康利, 永山稔, 今野愛, 信岡隆幸, 西館敏彦, 水口徹, 古畑智久, 平田公一

膵臓 23 ( 3 ) 443 - 443 2008.6

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術前に腫瘤を指摘しえなかった膵癌の1例

今野愛, 木村康利, 永山稔, 信岡隆幸, 古畑智久, 水口徹, 石渡裕俊, 林毅, 新津洋司郎, 平田公一

北海道外科雑誌 53 ( 1 ) 94 - 94 2008.6

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腫瘍性病変疑診例に対する腹腔鏡下膵切除

今野愛, 木村康利, 永山稔, 信岡隆幸, 今村将史, 秋月恵美, 水口徹, 古畑智久, 平田公一

日本臨床外科学会雑誌 69 ( 3 ) 714 - 714 2008.3

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腹腔鏡下脾臓摘出術の有用性開腹術との比較による臨床的検討

永山稔, 木村康利, 今野愛, 信岡隆幸, 西舘敏彦, 水口徹, 古畑智久, 平田公一

日本臨床外科学会雑誌 69 ( 3 ) 709 - 709 2008.3

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Proliferation of Hepatocyte Progenitor Cells Isolated From Adult Human Livers in Serum-Free Medium Reviewed

Kazunori Sasaki, Rtnko Kon, Toru Mizuguchi, Qijie Chen, Hidekazu Ooe, Hideki Oshima, Koichi Hirata, Toshihiro Mitaka

CELL TRANSPLANTATION 17 ( 10-11 ) 1221 - 1230 2008

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Short- and midterm outcomes of laparoscopy-assisted colectomy for colon and rectosigmoid cancer

Toshihiko Nishidate, Tomohisa Furuhata, Kenji Okita, Makoto Meguro, Gentaro Ishiyama, Takayuki Nobuoka, Koji Yamaguchi, Yasutoshi Kimura, Toru Mizuguchi, Fumitake Hata, Koichi Hirata

Tumor Research 43 31 - 37 2008

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In vitro transformation of adult rat hepatic progenitor cells into pancreatic endocrine hormone-producing cells. Reviewed

Hiroyuki Kawasaki, Toru Mizuguchi, Yamato Kikkawa, Hideki Oshima, Yasushi Sasaki, Takashi Tokino, Yasuo Kokai, Jun-Ichi Miyazaki, Tadashi Katsuramaki, Toshihiro Mitaka, Koichi Hirata

Journal of hepato-biliary-pancreatic surgery 15 ( 3 ) 310 - 7 2008

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BACKGROUND/PURPOSE: Pancreatic and duodenal homeobox factor 1 (Pdx-1) plays an important role in initiating differentiation toward pancreatic endocrine cells. The transdifferentiation or transformation of hepatocytes into pancreatic endocrine cells could be feasible, due to their similar cellular origins. Our goal in this study was to see if small hepatocytes (SHs) could give rise to pancreatic endocrine cells via exogenous Pdx-1 gene expression. METHODS: SHs were cultured for 10 days before adenovirus (Adt)-mediated Pdx-1 gene transfection. We performed western blot analysis for pancreatic transcription factors in the nuclei and reverse-transcription polymerase chain reaction (RT-PCR) for the gene expression of pancreatic endocrine hormones. Confocal laser microscanning analysis was used to observe the transformation of SHs. RESULTS: Pancreatic transcription factors such as Pdx-1, Ngn3, NeuroD, Nkx2.2, and Pax6 were induced after Adt-Pdx-1 gene transfection. The mRNA expression of pancreatic endocrine hormones (insulin, glucagon, and somatostatin) was induced after the gene transfection. Pdx-1 was expressed in the nucleus, where the cells were positive for one or more of the hormones and cytokeratin (CK) 8. Some cells were positive for multiple hormones. The insulin level increased while the glucagon level decreased after the glucose loading test, depending on the glucose concentration. CONCLUSIONS: SHs are transformed into functional pancreatic endocrine cells after Pdx-1 gene transfection.

DOI： 10.1007/s00534-007-1252-3

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Efficient transformation of small hepatocytes into insulin-expressing cells by forced expression of Pdx1. Reviewed

Kawasaki H, Mizuguchi T, Oshima H, Nobuoka T, Shibata T, Kaji S, Kokai Y, Katsuramaki T, Mitaka T, Hirata K

Journal of hepato-biliary-pancreatic surgery 15 403 - 409 2008

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DOI： 10.1007/s00534-007-1318-2

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Surgical treatment for gallbladder carcinoma with subserosal invasion

NOBUOKA Takayuki, KIMURA Yasutoshi, OHONO Keisuke, NISHIDATE Toshihiko, AKIZUKI Emi, MIZUGUCHI Toru, MUKAIYA Mitsuhiro, HIRATA Koichi

Tando 21 ( 5 ) 630 - 636 2007.12

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We investigated clinicopathological factors and prognosis for appropriate operation for 44 patients who received resections for gallbladder carcinoma with subserosal invasion. Their 5-year survival rate was 50.2%. There was a significant difference in the survival rate between the patients with and without hepatectomy, whereas there was no survival advantage for the anatomical liver resection or partial hepatectomy group cornpared with the extended cholecystectomy group. However, the 3-year survival rate of patients who underwent pancreaticoduodenectomy was 83.3%; the outcome after pancreaticoduodenectomy was comparable to that after resection of the bile duct. A significant difference in the survival rate was observed between lympahadectomy with D2 and D0/1. In particular, the tendency was remarkable in the gallbladder neck and cystic duct carcinoma. The significance of anatomical liver resection, pancreaticoduodenectomy, and resection of the bile duct was indistinct. The presence of lymph node metastasis was an independent prognostic factor by multivariate analyses. These results suggest that radical resection with hepatectomy and lympahadectomy with D2 is the appropriate procedure for gallbladder carcinoma with subserosal invasion.

Other Link： http://search.jamas.or.jp/link/ui/2008159607

DOI： 10.11210/tando1987.21.5_630

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腹腔鏡下脾臓摘出術の有用性開腹術との比較による臨床的検討

永山稔, 木村康利, 今野愛, 信岡隆幸, 水口徹, 古畑智久, 平田公一

北海道外科雑誌 52 ( 2 ) 144 - 147 2007.12

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Other Link： https://search.jamas.or.jp/default/link?pub_year=2007&ichushi_jid=J01375&link_issn=&doc_id=20080220220008&doc_link_id=%2Fdc7hksrg%2F2007%2F005202%2F009%2F0144-0147%26dl%3D0&url=https%3A%2F%2Fwww.medicalonline.jp%2Fjamas.php%3FGoodsID%3D%2Fdc7hksrg%2F2007%2F005202%2F009%2F0144-0147%26dl%3D0&type=MedicalOnline&icon=https%3A%2F%2Fjk04.jamas.or.jp%2Ficon%2F00004_2.gif

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New strategy for the antifibrotic therapy with oral administration of FR260330 (a selective inducible nitric oxide synthase inhibitor) in rat experimental liver cirrhosis

Hitoshi Kikuchi, Tadashi Katsuramaki, Kazuma Kukita, Sonofu Taketani, Makoto Meguro, Minoru Nagayama, Masato Isobe, Toru Mizuguchi, Koichi Hirata

Wound Repair and Regeneration 15 ( 6 ) 881 - 888 2007.11

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DOI： 10.1111/j.1524-475X.2007.00308.x

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Current status of surgery for pancreatic cancer. Reviewed

Hirata Koichi, Egawa Shinichi, Kimura Yasutoshi, Nobuoka Takayuki, Oshima Hidenori, Katsuramaki Tadashi, Mizuguchi Toru, Furuhata Tomohisa

Dig Surg 24 ( 2 ) 137 - 147 2007.4

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DOI： 10.1159/000102067

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Assessment of nutritional status and prediction of postoperative liver function from serum apolioprotein A-1 levels with hepatectomy Reviewed

Tadashi Katsuramaki, Toru Mizuguchi, Masaki Kawamoto, Kouji Yamaguchi, Makoto Meguro, Minoru Nagayama, Takayuki Nobuoka, Yasutoshi Kimura, Tomohisa Furuhata, Koichi Hirata

WORLD JOURNAL OF SURGERY 30 ( 10 ) 1886 - 1891 2006.10

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DOI： 10.1007/s00268-005-0590-z

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In situ graft-trimming method using polyester vascular prosthesis for inferior vena cava reconstruction after hepatectomy

Toru Mizuguchi, Tadashi Katsuramaki, Kiyofumi Morishita, Masaki Kawamoto, Takayuki Nobuoka, Masato Imamura, Yasutoshi Kimura, Koichi Hirata

Digestive Surgery 23 ( 1-2 ) 115 - 118 2006.8

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DOI： 10.1159/000094229

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Assessment of liver fibrosis by a noninvasive method of transient elastography and biochemical markers

Masaki Kawamoto, Toru Mizuguchi, Tadashi Katsuramaki, Minoru Nagayama, Hideki Oshima, Hiroyuki Kawasaki, Takayuki Nobuoka, Tasutoshi Kimura, Koichi Hirata

World Journal of Gastroenterology 12 ( 27 ) 4325 - 4330 2006.7

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DOI： 10.3748/wjg.v12.i27.4325

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Serum lipid and lipoprotein alterations represent recovery of liver function after hepatectomy Reviewed

M Kawamoto, T Mizuguchi, M Nagayama, T Nobuoka, H Kawasaki, T Sato, K Koito, S Parker, T Katsuramaki, K Hirata

LIVER INTERNATIONAL 26 ( 2 ) 203 - 210 2006.3

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DOI： 10.1111/j.1478-3231.2005.01217.x

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Liver repopulation and long-term function of rat small hepatocyte transplantation as an alternative cell source for hepatocyte transplantation Reviewed

C Shibata, T Mizuguchi, Y Kikkawa, T Nobuoka, H Oshima, H Kawasaki, M Kawamoto, T Katsuramaki, T Mitaka, K Hirata

LIVER TRANSPLANTATION 12 ( 1 ) 78 - 87 2006.1

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DOI： 10.1002/lt.20558

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Portal blood flow regulates volume recovery of the rat liver after partial hepatectomy: Molecular evaluation Reviewed

T. Nobuoka, T. Mizuguchi, H. Oshima, T. Shibata, Y. Kimura, T. Mitaka, T. Katsuramaki, K. Hirata

EUROPEAN SURGICAL RESEARCH 38 ( 6 ) 522 - 532 2006

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DOI： 10.1159/000096292

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Successful management of locally advanced hilar cholangiocarcinoma : Surgical procedure for extended left hepatic lobectomy coupled by resection/ reconstruction of the right hepatic artery

Akizuki Shindo Emi, Kimura Yasutoshi, Mukaiya Mitsuhiro, Honnma Toshio, Mizuguchi Toru, Furuhata Tomohisa, Koito Kazumitsu, Katsuramaki Tadashi, Hirata Koichi

Tumor Research 41 77 - 81 2006

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DOI： 10.15114/tr.41.77

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Hyperbaric oxygen stimulates cell proliferation and normalizes multidrug resistance protein-2 protein localization in primary rat hepatocytes Reviewed

T Mizuguchi, H Oshima, H Imaizumi, H Kohara, M Kawamoto, T Nobuoka, H Kawasaki, K Harada, Y Masuda, Y Kikkawa, T Mitaka, Y Asai, K Hirata

WOUND REPAIR AND REGENERATION 13 ( 6 ) 551 - 557 2005.11

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DOI： 10.1111/j.1524-475X.2005.00077.x

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Hepatic organoid formation in collagen sponge of cells isolated from human liver tissues Reviewed

S Sugimoto, K Harada, T Shiotani, S Ikeda, N Katsura, Ikai, I, T Mizuguchi, K Hirata, Y Yamaoka, T Mitaka

TISSUE ENGINEERING 11 ( 3-4 ) 626 - 633 2005.3

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DOI： 10.1089/ten.2005.11.626

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Biliary tract malignancy and chronic inflammation from the perspective of pancreaticobiliary maljunction Reviewed

Y Kimura, N Nishikawa, K Okita, T Furuhata, T Mizuguchi, T Nobuoka, H Nishimori, H Zenbutsu, M Satoh, T Katsuramaki, K Hirata

ONCOLOGY 69 41 - 45 2005

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DOI： 10.1159/000086632

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Hepatocyte transplantation for total liver repopulation. Reviewed

Mizuguchi T, Mitaka T, Katsuramaki T, Hirata K

Journal of hepato-biliary-pancreatic surgery 12 378 - 385 2005

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Publisher：5

DOI： 10.1007/s00534-005-0986-z

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A case of alveolar echinococcosis of the liver for which hepatectomy with hepatic artery and biliary resection was performed

NOBUOKA Takayuki, KATSURAMAKI Tadashi, MIZUGUCHI Toru, SHIMA Hiroaki, KIMURA Yasutoshi, MUKAIYA Mitsuhiro, HIRATA Koichi

Tando 18 ( 1 ) 81 - 87 2004.3

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We encountered a case of alveolar echinococcosis of the liver that was treated by extended left lobectomy with hepatic artery and biliary resection. A 58-year-old woman complained of jaundice and itching, and a hepatic tumor of the left lobe was noted by abdominal US and CT. She was finally diagnosed as having alveolar echinococcosis of the liver by serological tests. Endoscopic retrograde cholangiography showed an obstruction of the left hepatic duct and stenosis of the upper bile duct. Based on these observations, the echinococcosis seemed to extend to the extrahepatic bile duct. She received extended left lobectomy. Echinococcosis lesions extended to the hepatoduodenal ligament, and involved the upper bile duct and proper hepatic artery. We performed resection of the proper hepatic artery and reconstructed it between the right hepatic artery and proper hepatic artery. Bile duct resection and reconstruction (hepaticojejunostomy) was also performed. In conclusion, we succeeded in extended left lobectomy with reconstruction of the hepatic artery in a case of highly extended echinococcosis.

Other Link： http://search.jamas.or.jp/link/ui/2004174890

DOI： 10.11210/tando1987.18.1_81

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A case of giant hepatic hemangioma with spontaneous intratumoral bleeding <Case Report>

Nobuoka Takayuki, Katsuramaki Tadashi, Mizuguchi Toru, Shima Hiroaki, Kimura Yasutoshi, Mukaiya Mitsuhiro, Hirata Koichi

Tumor research : experimental and clinical 39 1 - 5 2004

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Other Link： http://ir.cc.sapmed.ac.jp/dspace/handle/123456789/205

DOI： 10.15114/tr.39.1

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Effects of bone marrow stromal cells on the structural and functional polarity of primary rat hepatocytes Reviewed

T Mizuguchi, K Palm, T Hui, T Aoki, Y Mochizuki, T Mitaka, AA Demetriou, J Rozga

IN VITRO CELLULAR & DEVELOPMENTAL BIOLOGY-ANIMAL 38 ( 2 ) 62 - 65 2002.2

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DOI： 10.1290/1071-2690(2002)038<0062:EOBMSC>2.0.CO;2

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Regulation of c-Met expression in rats with acute hepatic failure

T Mizuguchi, Y Kamohara, T Hui, T Neuman, T Mitaka, AA Demetriou, J Rozga

JOURNAL OF SURGICAL RESEARCH 99 ( 2 ) 385 - 396 2001.8

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DOI： 10.1006/jsre.2001.6216

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Effects of nicotinamide-related agents on the growth of primary rat hepatocytes and formation of small hepatocyte colonies

F Sato, T Mitaka, T Mizuguchi, Y Mochizuki, K Hirata

LIVER 19 ( 6 ) 481 - 488 1999.12

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DOI： 10.1111/j.1478-3231.1999.tb00080.x

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Reconstruction of hepatic organoid by rat small hepatocytes and hepatic nonparenchymal cells

T Mitaka, F Sato, T Mizuguchi, T Yokono, Y Mochizuki

HEPATOLOGY 29 ( 1 ) 111 - 125 1999.1

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DOI： 10.1002/hep.510290103

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Growth and maturation of small hepatocytes

T Mitaka, T Mizuguchi, F Sato, C Mochizuki, Y Mochizuki

JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY 13 S70 - S77 1998.9

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Mechanism of metastasis and tumor invasion in gastric carcinoma

Ryuichi Denno, Koichi Hirata, Takahiro Yasoshima, Takayuki Shishido, Hideki Ura, Koji Yamaguchi, Toru Mizuguchi, Fumihiko Sato

Japanese Journal of Gastroenterological Surgery 31 ( 4 ) 974 - 978 1998

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DOI： 10.5833/jjgs.31.974

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Subculture of proliferating adult rat hepatocytes in medium supplemented with nicotinamide and EGF Reviewed

T Mitaka, T Kojima, T Mizuguchi, Y Mochizuki

IN VITRO CELLULAR & DEVELOPMENTAL BIOLOGY-ANIMAL 32 ( 8 ) 469 - 477 1996.9

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Effects of oxygen radical scavengers on connexins 32 and 26 expression in primary cultures of adult rat hepatocytes Reviewed

T Kojima, T Mitaka, T Mizuguchi, Y Mochizuki

CARCINOGENESIS 17 ( 3 ) 537 - 544 1996.3

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Changes in cellular distribution of connexins 32 and 26 during formation of gap junctions in primary cultures of rat hepatocytes Reviewed

T Kojima, M Yamamoto, H Tobioka, T Mizuguchi, T Mitaka, Y Mochizuki

EXPERIMENTAL CELL RESEARCH 223 ( 2 ) 314 - 326 1996.3

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GROWTH AND MATURATION OF SMALL HEPATOCYTES ISOLATED FROM ADULT-RAT LIVER Reviewed

T MITAKA, T KOJIMA, T MIZUGUCHI, Y MOCHIZUKI

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS 214 ( 2 ) 310 - 317 1995.9

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electronic Patient Reported Outcome(ePRO)システムを活用した消化器外科手術後の手術部位感染が医療費に与える影響に関する検討

石貫智裕, 加藤透, 合田恵理香, 進士誠一, 吉田寛, 渡邉学, 横尾英樹, 柴田英貴, 青木武士, 問山裕二, 西森英史, 秦史壯, 水口徹

日本外科感染症学会雑誌 20 ( 5-6 ) 527 - 532 2024.9

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Other Link:： https://search.jamas.or.jp/default/link?pub_year=2024&ichushi_jid=J04188&link_issn=&doc_id=20240920460002&doc_link_id=%2Fdg9srgif%2F2023%2F002005%2F002%2F0527-0532%26dl%3D0&url=https%3A%2F%2Fwww.medicalonline.jp%2Fjamas.php%3FGoodsID%3D%2Fdg9srgif%2F2023%2F002005%2F002%2F0527-0532%26dl%3D0&type=MedicalOnline&icon=https%3A%2F%2Fjk04.jamas.or.jp%2Ficon%2F00004_2.gif

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オンラインPRO情報システムによる乳がん患者の精神状態と生活の質変化に関する研究

石貫智裕, 九冨五郎, 沖田憲司, 島宏彰, 和田朝香, 青木武士, 吉田寛, 渡邉学, 横尾英樹, 問山裕二, 大西浩文, 大柳俊夫, 水口徹

日本癌治療学会学術集会抄録集 60回 P63 - 5 2022.10

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【外科周術期における微生物検査の意義】肝胆膵領域の手術における周術期微生物検査の意義

永山稔, 今村将史, 太田盛道, 木村明菜, 加藤透, 及能大輔, 水口徹, 木村康利, 竹政伊知朗

日本外科感染症学会雑誌 17 ( 6 ) 520 - 526 2020.12

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膵臓悪性

山口洋志, 木村康利, 今村将史, 永山稔, 及能大輔, 村上武志, 伊東竜哉, 信岡隆幸, 水口徹, 竹政伊知朗

日本消化器外科学会雑誌 53 ( Suppl.2 ) 318 - 318 2020.11

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再肝切除症例に対する腹腔鏡下肝切除術-当科における手技の工夫と短期成績-

永山稔, 木村康利, 今村将史, 山口洋志, 及能大輔, 古来貴寛, 金澤あゆみ, 水口徹, 信岡隆幸, 竹政伊知朗

日本消化器外科学会雑誌(Web) 53 ( Supplement1 ) P239 - 3 2020

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近赤外蛍光色素で標識した単球による肝区域可視化技術の開発

及能大輔, Qian Baifeng, Ryschich Eduard, 村上武志, 山口洋志, 今村将史, 永山稔, 水口徹, 木村康利, 竹政伊知朗

日本消化器外科学会総会 74回 ( Supplement1 ) RS20 - 4 2019.7

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MCN疑い病変の取扱い-経過観察可能な病変はあるか? 術前経過に注目したMCN切除症例の検討

山口洋志, 木村康利, 今村将史, 永山稔, 及能大輔, 水口徹, 竹政伊知朗

膵臓 34 ( 3 ) A130 - A130 2019.6

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Immunohistological analysis of the unresectable pancreatic carcinoma after survivin 2B peptide vaccination

Terufumi Kubo, Giichiro Tsurita, Yoshihiko Hirohashi, Yasunori Ota, Hiroshi Yasui, Kazue Watanabe, Aiko Murai, Hiroko Asanuma, Hiroaki Shima, Ichiro Takemasa, Toru Mizuguchi, Noriyuki Sato, Toshihiko Torigoe

CANCER SCIENCE 109 1335 - 1335 2018.12

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サバイビン2Bペプチドワクチン第II相試験施行後の膵癌組織の免疫病理学的解析

久保輝文, 釣田義一郎, 廣橋良彦, 大田泰徳, 安井寛, 渡邉一絵, 村井愛子, 浅沼広子, 島宏彰, 塚原智英, 金関貴幸, 中津川宗秀, 水口徹, 竹政伊知朗, 平田公一, 佐藤昇志, 鳥越俊彦

日本臨床免疫学会総会プログラム・抄録集 46回 134 - 134 2018.11

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切除不能膵がんに対するサバイビン2Bペプチドワクチン療法後腫瘍組織の免疫病理学的検討(Immunohistological analysis of the unresectable pancreatic carcinoma after survivin 2B peptide vaccination)

久保輝文, 釣田義一郎, 廣橋良彦, 大田泰徳, 安井寛, 渡邉一絵, 村井愛子, 浅沼広子, 島宏彰, 竹政伊知朗, 水口徹, 佐藤昇志, 鳥越俊彦

日本癌学会総会記事 77回 2371 - 2371 2018.9

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サバイビン2Bペプチドワクチン第II相臨床試験における膵がん組織の免疫病理学的解析

久保輝文, 釣田義一郎, 廣橋良彦, 大田泰徳, 安井寛, 渡邉一絵, 村井愛子, 浅沼広子, 島宏彰, 塚原智英, 金関貴幸, 中津川宗秀, 水口徹, 竹政伊知朗, 平田公一, 佐藤昇志, 鳥越俊彦

日本がん免疫学会総会プログラム・抄録集 22回 93 - 93 2018.7

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サバイビン2Bペプチドワクチン第II相臨床試験における膵がん組織の免疫病理学的解析

久保輝文, 釣田義一郎, 廣橋良彦, 大田泰徳, 安井寛, 渡邉一絵, 村井愛子, 浅沼広子, 島宏彰, 塚原智英, 金関貴幸, 中津川宗秀, 水口徹, 竹政伊知朗, 平田公一, 佐藤昇志, 鳥越俊彦

日本がん免疫学会総会プログラム・抄録集 22回 93 - 93 2018.7

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膵癌における免疫療法-基礎と臨床- 進行膵がんに対するがん免疫療法

鳥越俊彦, 島宏彰, 水口徹, 木村康利, 竹政伊知朗, 釣田義一郎, 安井寛, 和田聡

膵臓 33 ( 3 ) 324 - 324 2018.5

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進行膵がんに対するがん免疫療法

鳥越俊彦, 島宏彰, 水口徹, 木村康利, 竹政伊知朗, 釣田義一郎, 安井寛, 和田聡

膵臓 33 ( 3 ) 324 - 324 2018.5

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UR膵癌に対する治療戦略切除不能膵癌に対する切除移行を踏まえた逐次治療による治療戦略の有用性北海道膵癌研究グループ(Hokkaido pancreatic cancer study group:HOPS)による多施設研究

木村康利, 今村将史, 中村透, 永山稔, 山口洋志, 吉田瑛士, 水口徹, 平野聡, 竹政伊知朗

日本外科学会定期学術集会抄録集 118回 615 - 615 2018.4

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Propensity解析を用いた胆道癌に対する化学・放射線療法後切除症例の検討

河野剛, 木村康利, 今村将史, 及能大輔, 山口洋志, 永山稔, 信岡隆幸, 水口徹, 竹政伊知朗

日本外科学会定期学術集会抄録集 117回 PS - 214 2017.4

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Current status of the prognostic molecular biomarkers in breast cancer: A systematic review

Goro Kutomi, Toru Mizuguchi, Fukino Satomi, Hideki Maeda, Hiroaki Shima, Yasutoshi Kimura, Koichi Hirata

ONCOLOGY LETTERS 13 ( 3 ) 1491 - 1498 2017.3

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DOI： 10.3892/ol.2017.5609

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右副腎巨大褐色細胞腫摘出において肝脱転前の生食ジェット法が有用であった1例

目黒誠, 水口徹, 沖田憲司, 西舘敏彦, 植木知身, 秋月恵美, 及能大輔, 信岡隆幸, 木村康利, 竹政伊知朗

IVR: Interventional Radiology 32 ( 1 ) 79 - 79 2017.3

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大腸癌切除後の異時性肝単独転移例に対する術前化学療法の意義についての検討

及能大輔, 沖田憲司, 古畑智久, 西舘敏彦, 植木知身, 秋月恵美, 原田敬介, 信岡隆幸, 木村康利, 水口徹, 佐々木一晃, 平田公一

日本大腸肛門病学会雑誌 70 ( 2 ) 136 - 136 2017.2

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進行膵臓がんを対象とした複合型CTLワクチン療法第2相試験

水口徹, 島宏彰, 九冨五郎, 木村康利, 竹政伊知朗, 鳥越俊彦, 廣橋良彦, 塚原智英, 金関貴幸, 釣田義一郎, 安井寛, 和田聡, 林宏至, 宮腰崇

日本臨床外科学会雑誌 78 2017

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当初切除不能であった局所進行膵癌に対し、化学放射線療法後に動脈合併切除再建を伴う拡大切除を行った3例

河野剛, 木村康利, 今村将史, 伊東竜哉, 山口洋志, 及能大輔, 目黒誠, 水口徹, 竹政伊知朗

北海道外科雑誌 61 ( 2 ) 194 - 195 2016.12

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肝嚢胞の経時的な増大を認め卵巣顆粒膜細胞腫の転移と診断し切除術を行った1例

山口洋志, 木村康利, 及能大輔, 河野剛, 今村将史, 沖田憲司, 信岡隆幸, 水口徹, 竹政伊知朗

北海道外科雑誌 61 ( 2 ) 188 - 189 2016.12

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CA19-9高値を示した径12cmの脾門部嚢胞性腫瘤に対し、腹腔鏡下尾側膵切除術を施行した一例

河野剛, 木村康利, 及能大輔, 山口洋志, 今村将史, 目黒誠, 水口徹, 竹政伊知朗

日本内視鏡外科学会雑誌 21 ( 7 ) DP107 - 4 2016.12

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診断に苦慮した膵嚢胞性病変の1例

河野剛, 木村康利, 及能大輔, 山口洋志, 今村将史, 目黒誠, 水口徹, 竹政伊知朗

日本臨床外科学会雑誌 77 ( 11 ) 2812 - 2812 2016.11

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巨大脾嚢胞に対して腹腔鏡下嚢胞天蓋切除術を施行した2症例

及能大輔, 水口徹, 河野剛, 山口洋志, 目黒誠, 今村将史, 木村康利, 沖田憲司, 信岡隆幸, 竹政伊知朗

日本臨床外科学会雑誌 77 ( 11 ) 2813 - 2813 2016.11

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局所進行膵癌根治術における動脈合併切除再建の在り方

河野剛, 木村康利, 今村将史, 伊東竜哉, 山口洋志, 及能大輔, 目黒誠, 信岡隆幸, 水口徹, 竹政伊知朗

日本臨床外科学会雑誌 77 ( 増刊 ) 770 - 770 2016.10

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当科における散発性非機能性膵神経内分泌腫瘍の特徴と治療成績

山口洋志, 木村康利, 今村将史, 伊東竜哉, 及能大輔, 河野剛, 水口徹, 竹政伊知朗

日本臨床外科学会雑誌 77 ( 増刊 ) 482 - 482 2016.10

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DOI： 10.3919/jjsa.77.482

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安全・正確な肝離断のための工夫肝離断に関する現時点で考えられる理想的方法と工夫

水口徹, 目黒誠, 今村将史, 及能大輔, 山口洋志, 河野剛, 沖田憲司, 西舘敏彦, 木村康利, 竹政伊知朗

日本臨床外科学会雑誌 77 ( 増刊 ) 374 - 374 2016.10

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UR膵癌に対するconversion surgeryの現状

今村将史, 木村康利, 山口洋志, 及能大輔, 河野剛, 信岡隆幸, 水口徹, 竹政伊知朗

日本臨床外科学会雑誌 77 ( 増刊 ) 472 - 472 2016.10

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成人小腸間膜リンパ管腫の一切除例

渡久山晃, 及能大輔, 植木知身, 沖田憲司, 西舘敏彦, 目黒誠, 秋月恵美, 水口徹, 古畑智久, 信岡隆幸, 木村康利, 竹政伊知朗

日本臨床外科学会雑誌 77 ( 9 ) 2330 - 2331 2016.9

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腹壁静脈怒張が著明な肝細胞癌症例に対してオプティカル法で腹腔鏡ポート留置を施行した一例

及能大輔, 目黒誠, 水口徹, 植木知身, 秋月恵美, 西舘敏彦, 沖田憲司, 信岡隆幸, 木村康利, 古畑智久, 竹政伊知朗

日本臨床外科学会雑誌 77 ( 9 ) 2332 - 2332 2016.9

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当科における膵・胆管合流異常切除症例の解析

河野剛, 木村康利, 今村将史, 伊東竜哉, 山口洋志, 及能大輔, 目黒誠, 信岡隆幸, 水口徹, 竹政伊知朗

日本膵・胆管合流異常研究会プロシーディングス 39 58 - 59 2016.8

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腹壁瘢痕ヘルニア、術後合併症からみた当科における術式の変遷

植木知身, 沖田憲司, 西舘敏彦, 秋月恵美, 及能大輔, 目黒誠, 水口徹, 古畑智久, 竹政伊知朗

日本消化器外科学会総会 71回 VD8 - 8 2016.7

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腹腔鏡下天蓋切除術を施行した嚢胞内出血を伴う単純性肝嚢胞の一例

及能大輔, 目黒誠, 水口徹, 秋月恵美, 植木知身, 西舘敏彦, 沖田憲司, 信岡隆幸, 木村康利, 古畑智久, 竹政伊知朗

北海道外科雑誌 61 ( 1 ) 117 - 117 2016.6

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腹腔鏡下腹壁瘢痕ヘルニア修復術後の慢性疼痛に対し手術を行った一例

渡久山晃, 植木知身, 西舘敏彦, 目黒誠, 及能大輔, 秋月恵美, 水口徹, 古畑智久, 沖田憲司, 竹政伊知朗

北海道外科雑誌 61 ( 1 ) 123 - 123 2016.6

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膵癌細胞の遊走・浸潤へ密接に関係する新規細胞間接着分子LSRの制御機構

及能大輔, 河野剛, 伊東竜哉, 沖田憲司, 信岡隆幸, 木村康利, 水口徹, 古畑智久, 小島隆, 平田公一

日本外科学会定期学術集会抄録集 116回 PS - 029 2016.4

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肝細胞癌術前BCAA製剤内服による予後への影響についてバイオマーカーとしてのBTR変動の意義

目黒誠, 水口徹, 沖田憲司, 西舘敏彦, 植木知身, 秋月恵美, 及能大輔, 今村将史, 信岡隆幸, 木村康利, 平田公一

日本外科学会定期学術集会抄録集 116回 PS - 017 2016.4

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大腸癌切除後の異時性肝単独転移例に対する術前化学療法の意義についての検討

沖田憲司, 古畑智久, 西舘敏彦, 植木知身, 秋月恵美, 及能大輔, 今村将史, 目黒誠, 信岡隆幸, 木村康利, 水口徹, 秦史壮, 佐々木一晃, 平田公一

日本外科学会定期学術集会抄録集 116回 PS - 145 2016.4

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肝脱転前の生食ジェット注入法が有用であった右副腎巨大褐色細胞腫の1例

及能大輔, 目黒誠, 水口徹, 植木知身, 秋月恵美, 西舘敏彦, 沖田憲司, 信岡隆幸, 木村康利, 古畑智久, 平田公一

日本臨床外科学会雑誌 77 ( 3 ) 710 - 710 2016.3

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大腸癌切除後の異時性肝単独転移例に対する術前化学療法の意義についての検討

沖田憲司, 西舘敏彦, 植木知身, 秋月恵美, 及能大輔, 目黒誠, 九冨五郎, 信岡隆幸, 木村康利, 水口徹, 古畑智久, 平田公一

日本臨床外科学会雑誌 77 ( 3 ) 706 - 707 2016.3

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孤立性上腸間膜動脈解離に対して保存的治療にて経過した一例

渡久山晃, 西舘敏彦, 沖田憲司, 植木知身, 秋月恵美, 及能大輔, 目黒誠, 九冨五郎, 信岡隆幸, 木村康利, 水口徹, 古畑智久, 平田公一

日本臨床外科学会雑誌 77 ( 3 ) 705 - 705 2016.3

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腹部救急疾患に対する内視鏡下手術下部消化管憩室炎によるS状結腸膀胱瘻に対する腹腔鏡下手術

及能大輔, 古畑智久, 沖田憲司, 植木知身, 秋月恵美, 西舘敏彦, 伊東竜哉, 今村将史, 目黒誠, 信岡隆幸, 木村康利, 水口徹, 平田公一

日本腹部救急医学会雑誌 36 ( 2 ) 364 - 364 2016.2

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生食ジェット法を用いた下大静脈近傍腫瘍へのアプローチ法の工夫について

目黒誠, 水口徹, 沖田憲司, 西舘敏彦, 植木知身, 秋月恵美, 及能大輔, 今村将史, 信岡隆幸, 木村康利, 平田公一

日本腹部救急医学会雑誌 36 ( 2 ) 482 - 482 2016.2

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Trials of vaccines for pancreatic ductal adenocarcinoma: Is there any hope of an improved prognosis?

Toru Mizuguchi, Toshihiko Torigoe, Fukino Satomi, Hiroaki Shima, Goro Kutomi, Shigenori Ota, Masayuki Ishii, Hiroshi Hayashi, Sumiyo Asakura, Yoshihiko Hirohashi, Makoto Meguro, Yasutoshi Kimura, Toshihiko Nishidate, Kenji Okita, Masaho Ishino, Atsushi Miyamoto, Masamitsu Hatakenaka, Noriyuki Sato, Koichi Hirata

SURGERY TODAY 46 ( 2 ) 139 - 148 2016.2

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DOI： 10.1007/s00595-015-1120-8

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S状結腸憩室炎による結腸膀胱瘻に対して腹腔鏡下手術を施行した一例

秋月恵美, 沖田憲司, 植木知身, 西舘敏彦, 及能大輔, 古畑智久, 目黒誠, 木村康利, 水口徹

日本内視鏡外科学会雑誌 20 ( 7 ) OS147 - 2 2015.12

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グリソン鞘に沿った進展形式をとった転移性肝癌の一切除例

及能大輔, 目黒誠, 水口徹, 植木知身, 秋月恵美, 西舘敏彦, 沖田憲司, 信岡隆幸, 木村康利, 古畑智久, 平田公一, 斉藤正人, 守田玲菜

北海道外科雑誌 60 ( 2 ) 198 - 198 2015.12

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腹腔鏡下側方廓清のピットフォールとその対策腹腔鏡下側方郭清におけるリンパ嚢胞発症のrisk factorに関する検討

沖田憲司, 古畑智久, 西舘敏彦, 植木知身, 秋月恵美, 及能大輔, 伊東竜哉, 原田敬介, 今村将史, 目黒誠, 信岡隆幸, 木村康利, 水口徹, 佐々木一晃, 平田公一

日本内視鏡外科学会雑誌 20 ( 7 ) WS9 - 7 2015.12

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二期的に腹腔鏡下腹壁瘢痕ヘルニア修復術を施行した一例

植木知身, 沖田憲司, 西舘敏彦, 目黒誠, 秋月恵美, 及能大輔, 信岡隆幸, 木村康利, 水口徹, 古畑智久

日本内視鏡外科学会雑誌 20 ( 7 ) OS219 - 8 2015.12

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当科における腹腔鏡(補助)下肝切除術の現状について

目黒誠, 水口徹, 沖田憲司, 西舘敏彦, 植木知身, 秋月恵美, 及能大輔, 今村将史, 信岡隆幸, 木村康利, 古畑智久, 平田公一

日本内視鏡外科学会雑誌 20 ( 7 ) OS37 - 1 2015.12

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肝胆膵手術における術後感染症対策当施設における肝切除術後創感染予防に関する抗菌薬投与法および創管理法の工夫について

目黒誠, 水口徹, 沖田憲司, 西舘敏彦, 植木知身, 秋月恵美, 及能大輔, 信岡隆幸, 木村康利, 古畑智久, 平田公一

日本外科感染症学会雑誌 12 ( 5 ) 462 - 462 2015.11

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肝生検で高分化型肝細胞癌との鑑別が困難であった多発肝細胞腺腫の1切除例

田村文人, 河野豊, 宮西浩嗣, 久保智洋, 神原悠輔, 岡川泰, 石川和真, 高田弘一, 林毅, 佐藤勉, 佐藤康史, 小船雅義, 瀧本理修, 川本雅樹, 目黒誠, 水口徹, 荻野次郎, 長谷川匡, 米田憲秀, 佐々木素子, 加藤淳二

肝臓 56 ( 11 ) 584 - 595 2015.11

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緊急手術後の深部静脈血栓症に起因する敗血症性肺塞栓症の一例

及能大輔, 目黒誠, 水口徹, 植木知身, 秋月恵美, 西舘敏彦, 沖田憲司, 信岡隆幸, 木村康利, 古畑智久, 平田公一

日本外科感染症学会雑誌 12 ( 5 ) 555 - 555 2015.11

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腹腔鏡下腹壁瘢痕ヘルニア修復術後の慢性疼痛に対する治療経験

植木知身, 沖田憲司, 西舘敏彦, 目黒誠, 秋月恵美, 及能大輔, 信岡隆幸, 木村康利, 水口徹, 古畑智久

日本臨床外科学会雑誌 76 ( 増刊 ) 1013 - 1013 2015.10

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DOI： 10.3919/jjsa.76.1013

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肝細胞癌初回肝切除術前の分枝鎖アミノ酸製剤内服の意義について BTR値の術前変動からみた検討

目黒誠, 水口徹, 沖田憲司, 西舘敏彦, 植木知身, 秋月恵美, 及能大輔, 信岡隆幸, 木村康利, 古畑智久, 平田公一

日本臨床外科学会雑誌 76 ( 増刊 ) 528 - 528 2015.10

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【生活習慣病と消化器疾患】生活習慣と胆のう癌、胆管癌

平田公一, 信岡隆幸, 巽博臣, 荒川朋子, 秋月恵美, 今村将史, 木村康利, 及能大輔, 太田盛道, 小川宰司, 沖田憲司, 水口徹

Modern Physician 35 ( 10 ) 1243 - 1249 2015.10

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Other Link:： http://search.jamas.or.jp/link/ui/2016019499

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遠隔転移を有する大腸癌に対する腹腔鏡下手術症例の検討

西舘敏彦, 古畑智久, 沖田憲司, 植木知身, 秋月恵美, 及能大輔, 目黒誠, 信岡隆幸, 木村康利, 水口徹, 秦史壮, 佐々木一晃, 平田公一

日本臨床外科学会雑誌 76 ( 増刊 ) 709 - 709 2015.10

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DOI： 10.3919/jjsa.76.709

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直腸癌集学的治療における放射線療法とSSIとの関連とその対策

植木知身, 沖田憲司, 西舘敏彦, 目黒誠, 秋月恵美, 及能大輔, 木村康利, 水口徹, 古畑智久, 平田公一

日本大腸肛門病学会雑誌 68 ( 9 ) 720 - 720 2015.9

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【危惧する感染症-院内感染防止対策-】B型肝炎ウイルス感染症に関する最近の動向

水口徹, 目黒誠, 沖田憲司, 西舘敏彦, 信岡隆幸, 今村将史, 河野豊, 高木秀安, 佐々木茂, 宮西浩嗣, 加藤淳二, 平田公一

Surgery Frontier 22 ( 3 ) 221 - 226 2015.9

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直腸肛門内圧検査による直腸術後肛門機能の評価

秋月恵美, 古畑智久, 西舘敏彦, 沖田憲司, 植木知身, 及能大輔, 目黒誠, 木村康利, 水口徹

日本大腸肛門病学会雑誌 68 ( 9 ) 649 - 649 2015.9

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What's New in SURGERY FRONTIER(第86回) 常在細菌叢の解析と治療的応用 NASHと腸内細菌叢

目黒誠, 水口徹, 沖田憲司, 西舘敏彦, 植木知身, 秋月恵美, 及能大輔, 信岡隆幸, 木村康利, 平田公一

Surgery Frontier 22 ( 3 ) 250 - 254 2015.9

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合併切除を要した進行結腸癌の腹腔鏡下手術とその成績

西舘敏彦, 古畑智久, 沖田憲司, 植木知身, 秋月恵美, 及能大輔, 目黒誠, 木村康利, 水口徹, 佐々木一晃, 平田公一

日本大腸肛門病学会雑誌 68 ( 9 ) 674 - 674 2015.9

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直腸癌同時性肝転移に対して術前全身化学療法後に腹腔鏡下同時切除を施行し得た1例

目黒誠, 水口徹, 沖田憲司, 西舘敏彦, 植木知身, 秋月恵美, 及能大輔, 信岡隆幸, 木村康利, 古畑智久, 平田公一

日本癌治療学会誌 50 ( 3 ) 2473 - 2473 2015.9

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The impact of aging on morbidity and mortality after liver resection: a systematic review and meta-analysis

Toru Mizuguchi, Masaki Kawamoto, Makoto Meguro, Kenji Okita, Shigenori Ota, Masayuki Ishii, Tomomi Ueki, Toshihiko Nishidate, Yasutoshi Kimura, Tomohisa Furuhata, Koichi Hirata

SURGERY TODAY 45 ( 3 ) 259 - 270 2015.3

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DOI： 10.1007/s00595-014-0863-y

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孤立性上腸間膜動脈解離に対して保存的治療にて経過した一例

西舘敏彦, 古畑智久, 沖田憲司, 植木知身, 秋月恵美, 伊東竜哉, 目黒誠, 今村将史, 信岡隆幸, 木村康利, 水口徹, 平田公一

日本腹部救急医学会雑誌 35 ( 2 ) 533 2015.2

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右横隔膜ドーム直下の小型肝細胞癌に対して完全腹腔鏡下肝ラジオ波焼灼術を施行した1例

目黒誠, 水口徹, 川本雅樹, 橋本亜紀, 今村将史, 木村康利, 古畑智久, 平田公一, 田村文人, 河野豊, 宮西浩嗣, 加藤淳二

IVR: Interventional Radiology 29 ( 4 ) 425 - 425 2014.12

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腹腔鏡下胃切除術;エキスパートの手術を学ぶ腹腔鏡下幽門側胃切除術

信岡隆幸, 伊東竜哉, 及能拓朗, 西舘俊彦, 今村雅史, 木村康利, 水口徹, 古畑智久, 平田公一

消化器外科 37 ( 12 ) 1775 - 1783 2014.11

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The Clinical Implication of Repeat Pancreatectomy for Recurrent Pancreatic Cancer in the Remnant Pancreas After Initial Pancreatectomy

T. Kyuno, Y. Kimura, M. Imamura, T. Ito, T. Nobuoka, T. Mizuguchi, T. Furuhata, K. Hirata

PANCREAS 43 ( 8 ) 1383 - 1383 2014.11

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StageIV胃癌に対するconversion therapy症例の検討

信岡隆幸, 伊東竜哉, 西舘敏彦, 沖田憲司, 今村雅史, 及能拓朗, 木村康利, 水口徹, 古畑智久, 平田公一

日本臨床外科学会雑誌 75 623 2014.10

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術前確定診断が得られなかった潜在型膵癌の1例

及能拓朗, 木村康利, 沖田憲司, 今村将史, 伊東竜哉, 信岡隆幸, 西舘敏彦, 目黒誠, 九冨五郎, 水口徹, 古畑智久, 平田公一

日本臨床外科学会雑誌 75 707 2014.10

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膵頭十二指腸切除後の膵空腸吻合部狭窄に対して再吻合術を施行した2例

今村将史, 木村康利, 伊東竜哉, 及能拓朗, 信岡隆幸, 目黒誠, 水口徹, 平田公一

日本臨床外科学会雑誌 75 771 2014.10

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当科における遠隔転移のない他臓器浸潤直腸癌の治療成績

沖田憲司, 古畑智久, 西舘敏彦, 植木知身, 秋月恵美, 伊東竜哉, 川本雅樹, 目黒誠, 信岡隆幸, 木村康利, 水口徹, 平田公一

日本臨床外科学会雑誌 75 ( 9 ) 2633 - 2634 2014.9

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下部消化管術後創感染の危険因子の解析

植木知身, 沖田憲司, 目黒誠, 川本雅樹, 秋月恵美, 及能拓朗, 伊東竜哉, 西舘敏彦, 信岡隆幸, 木村康利, 水口徹, 古畑智久, 平田公一

日本臨床外科学会雑誌 75 ( 9 ) 2629 2014.9

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術前AI療法を施行した巨大膵周囲脂肪肉腫の1切除例

石井雅之, 木村康利, 高田弘一, 信岡隆幸, 今村将史, 目黒誠, 西舘敏彦, 伊東竜哉, 及能大輔, 水口徹, 古畑智久, 加藤淳二, 平田公一

日本臨床外科学会雑誌 75 ( 9 ) 2629 - 2630 2014.9

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膵頭部に発生した成熟奇形腫の1例

安田尚美, 木村康利, 今村将史, 伊東竜哉, 西舘敏彦, 沖田憲司, 信岡隆幸, 水口徹, 古畑智久, 平田公一

北海道外科雑誌 59 ( 1 ) 88 2014.6

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直近の10年におけるTS1膵癌切除例の臨床病理学的検討

今村将史, 木村康利, 伊東竜哉, 石井雅之, 沖田憲司, 信岡隆幸, 水口徹, 古畑智久, 平田公一

すい臓 29 ( 3 ) 579 2014.6

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Propensity scoreを用いた下部消化管術後創感染のrisk factorの解析

植木知身, 沖田憲司, 目黒誠, 川本雅樹, 秋月恵美, 及能拓朗, 伊東竜哉, 西舘敏彦, 信岡隆幸, 木村康利, 水口徹, 古畑智久, 平田公一

日本外科学会雑誌 115 663 2014.3

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IS-6-2 Clinical role of aldehyde dehydrogenase 1 expression in NBNC hepatocellular carcinoma patients after initial hepatectomy(IS-6 International Session (6) Hepato-biliary surgery-1)

Journal of Japan Surgical Society 115 ( 2 ) 93 - 93 2014.3

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術前化学療法を施行した胃癌手術症例に対する経腸栄養管理の検討

秋月恵美, 信岡隆幸, 西舘敏彦, 伊東竜哉, 石井雅之, 木村康利, 水口徹, 古畑智久, 平田公一

日本外科学会雑誌 115 855 2014.3

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PS-041-7 当科におけるStageIV大腸癌(肝転移単独は除外)に対する切除の適応と限界(PS-041 大腸再発・予後-1,ポスターセッション,第114回日本外科学会定期学術集会)

沖田憲司, 古畑智久, 西舘敏彦, 植木知身, 秋月恵美, 及能拓朗, 原田敬介, 川本雅樹, 九冨五郎, 目黒誠, 今村将史, 信岡隆幸, 木村康利, 水口徹, 秦史壮, 佐々木一晃, 平田公一

日本外科学会雑誌 115 ( 2 ) 2014.3

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S状結腸憩室穿通に対して腹腔鏡下結腸切除術を施行した1例

西舘敏彦, 古畑智久, 沖田憲司, 植木知身, 伊東竜哉, 秋月恵美, 目黒誠, 信岡隆幸, 木村康利, 水口徹, 平田公一

日本腹部救急医学会雑誌 34 ( 2 ) 451 2014.2

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UPDATE OF REGENERATIVE MEDICINE OF THE HEPATIC STEM CELLS

T. Mizuguchi, Y. Ichinohe, Y. Nakmaura, T. Shibata, N. Tanimizu, Y. Kikkawa, T. Mitaka, K. Hirata

WOUND REPAIR AND REGENERATION 22 ( 1 ) A1 - A1 2014.1

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Web of Science

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【ロボット手術とハイブリッド手術室】ハイブリッド手術室での取り組み消化器外科領域

平田公一, 木村康利, 今村将史, 石井雅之, 太田盛道, 及能大輔, 久木田和晴, 及能拓朗, 水口徹, 樋上哲哉

消化器外科 37 ( 1 ) 87 - 94 2014.1

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Ichushi

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Preoperative liver function assessments to estimate the prognosis and safety of liver resections

Toru Mizuguchi, Masaki Kawamoto, Makoto Meguro, Thomas T. Hui, Koichi Hirata

SURGERY TODAY 44 ( 1 ) 1 - 10 2014.1

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DOI： 10.1007/s00595-013-0534-4

Web of Science

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胃癌術後SSI発生における術前背景因子に関する検討

信岡隆幸, 西舘敏彦, 伊東竜哉, 目黒誠, 沖田憲司, 石井雅之, 木村康利, 水口徹, 古畑智久, 平田公一

日本胃癌学会総会記事 86th 243 2014

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腹腔鏡下大動脈周囲リンパ節生検の経験

信岡隆幸, 伊東竜哉, 西舘敏彦, 沖田憲司, 今村雅史, 及能拓朗, 木村康利, 水口徹, 古畑智久, 平田公一

日本内視鏡外科学会雑誌 19 ( 7 ) 548 2014

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術前化学(放射線)療法を施行した直腸癌切除症例の検討

西舘敏彦, 古畑智久, 沖田憲司, 植木知身, 秋月恵美, 伊東竜哉, 信岡隆幸, 木村康利, 水口徹, 平田公一

大腸癌研究会プログラム・抄録集 80th 65 2014

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Saline injection method in reply to julianov

Toru Mizuguchi, Makoto Meguro, Thomas T. Hui

Journal of the American College of Surgeons 219 ( 6 ) 1198 - 1199 2014

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DOI： 10.1016/j.jamcollsurg.2014.09.005

PubMed

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医師主導型治験として施行したSUCCESS試験(臨床第I相試験)の結果

水口徹, 島宏彰, 九冨五郎, 鳥越俊彦, 林宏至, 西舘敏彦, 沖田憲司, 川本雅樹, 佐藤昇志, 平田公一

日本消化器外科学会雑誌(Web) 47 ( Supplement1 ) 2014

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Comprehensive review of post-liver resection surgical complications and a new universal classification and grading system

Masayuki Ishii, Toru Mizuguchi, Kohei Harada, Shigenori Ota, Makoto Meguro, Tomomi Ueki, Toshihiko Nishidate, Kenji Okita, Koichi Hirata

World Journal of Hepatology 6 ( 10 ) 745 - 751 2014

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DOI： 10.4254/wjh.v6.i10.745

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膵NET・肝IPNB併存の過小残肝容積症例に対してPTPEと膵頭切除を施行後,2期的に肝切除を施行した1例

目黒誠, 木村康利, 石井雅之, 西舘敏彦, 伊東竜哉, 信岡隆幸, 水口徹, 古畑智久, 平田公一

北海道外科雑誌 58 ( 2 ) 187 2013.12

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完全内臓逆位をともなう胆管癌の2症例

及能大輔, 木村康利, 今村将史, 植木知身, 内山素伸, 石井雅之, 目黒誠, 川本雅樹, 林毅, 中西勝也, 藤田朋紀, 松本岳, 水口徹, 平田公一

日本臨床外科学会雑誌 74 ( 12 ) 3505 - 3505 2013.12

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膵中央切除、膵(管)膵(管)吻合にて治療したインスリノーマの一例

石井雅之, 木村康利, 今村将史, 植木知身, 内山素伸, 及能大輔, 本谷雅代, 水口徹, 篠村恭久, 平田公一

日本臨床外科学会雑誌 74 ( 12 ) 3506 - 3506 2013.12

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胆摘後に発覚した胆嚢癌に対する二期的根治術のアウトカム

木村康利, 信岡隆幸, 目黒誠, 西舘敏彦, 伊東竜哉, 石井雅之, 水口徹, 古畑智久, 平田公一

日本臨床外科学会雑誌 74 394 2013.10

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下部進行直腸癌の治療成績と問題点

古畑智久, 沖田憲司, 西舘敏彦, 植木知身, 秋月恵美, 伊東竜哉, 小川宰司, 久木田和晴, 及能拓朗, 木村康利, 水口徹, 佐々木一晃, 平田公一

日本臨床外科学会雑誌 74 372 2013.10

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切除不能胃癌に対するDocetaxel/CDDP/S‐1(DCS)療法後のConversion surgery

信岡隆幸, 西舘敏彦, 伊東竜哉, 目黒誠, 沖田憲司, 石井雅之, 木村康利, 水口徹, 古畑智久, 平田公一

日本臨床外科学会雑誌 74 643 2013.10

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【肥満の基礎と臨床】特集によせて肥満の疫学と最近のトピックス

平田公一, 小川宰司, 河野剛, 石井雅之, 及能大輔, 九冨五郎, 木村康利, 水口徹

Surgery Frontier 20 ( 3 ) 249 - 254 2013.9

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放射線化学療法後にSalvage surgeryを施行したcStage IVb胆道がん症例の解析

木村康利, 信岡隆幸, 目黒誠, 今村将史, 西舘敏彦, 伊東竜哉, 石井正行, 水口徹, 平田公一

胆道 27 ( 3 ) 490 2013.8

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膵・十二指腸NET症例における術前後病理診断の乖離について

木村康利, 今村将史, 及能大輔, 石井雅之, 川本雅樹, 目黒誠, 水口徹, 長谷川匡, 平田公一

日本消化器外科学会総会 68回 O - 18 2013.7

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分枝型IPMC22例についての検討

石井雅之, 木村康利, 今村将史, 及能大輔, 川本雅樹, 目黒誠, 水口徹, 平田公一, 長谷川匡

日本消化器外科学会総会 68回 P - 112 2013.7

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膵癌切除後長期生存例の臨床学的検討

及能大輔, 木村康利, 今村将史, 石井雅之, 川本雅樹, 目黒誠, 水口徹, 古畑智久, 平田公一

日本消化器外科学会総会 68回 P - 17 2013.7

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最新のSurgical Site Infection(SSI)予防策と対処法膵頭十二指腸切除後の膵液瘻と細菌感染の関与術後早期のIVRの重要性

今村将史, 木村康利, 及能大輔, 石井雅之, 川本雅樹, 目黒誠, 水口徹, 古畑智久, 平田公一

日本消化器外科学会総会 68回 PD - 2 2013.7

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術前放射線化学療法施行後にR0手術を施行し得た局所進行直腸癌の1例

久木田和晴, 古畑智久, 西舘敏彦, 植木知身, 秋月恵美, 伊東竜哉, 沖田憲司, 信岡隆幸, 木村康利, 水口徹, 平田公一

北海道外科雑誌 58 ( 1 ) 64 2013.6

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Stage IV膵癌に対する手術前治療の妥当性

木村康利, 今村将史, 及能大輔, 石井正之, 目黒誠, 川本雅樹, 水口徹, 古畑智久, 平田公一

膵臓 28 ( 3 ) 463 - 463 2013.6

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肝細胞癌における細胞接着分子ルテランの放出メカニズムの解明

小川貴穂, 三輪隆博, 谷水直樹, 門谷裕一, 水口徹, 平田公一, 野水基義, 三高俊広, 吉川大和

日本結合組織学会学術大会・マトリックス研究会大会合同学術集会プログラム・抄録集 45回・60回 125 - 125 2013.6

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膵頭部癌における幽門下リンパ節転移陽性症例の検討

及能大輔, 木村康利, 今村将史, 石井雅之, 目黒誠, 川本雅樹, 水口徹, 古畑智久, 平田公一

日本肝胆膵外科学会・学術集会プログラム・抄録集 25回 497 - 497 2013.6

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膵中央切除、膵膵吻合にて治療したインスリノーマの1例

石井雅之, 木村康利, 今村将史, 内山素伸, 植木知身, 及能大輔, 水口徹, 古畑智久, 平田公一

日本肝胆膵外科学会・学術集会プログラム・抄録集 25回 439 - 439 2013.6

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幽門側胃切除症例に対し尾側膵切除術を施行した3例

石井雅之, 木村康利, 今村将史, 及能大輔, 川本雅樹, 目黒誠, 水口徹, 古畑智久, 平田公一

北海道外科雑誌 58 ( 1 ) 81 - 81 2013.6

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膵頭十二指腸切除後膵液瘻の危険因子

今村将史, 木村康利, 及能大輔, 石井雅之, 川本雅樹, 目黒誠, 水口徹, 古畑智久, 平田公一

日本肝胆膵外科学会・学術集会プログラム・抄録集 25回 563 - 563 2013.6

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Borderline resectability膵癌の治療方針と成績 Stage IV膵癌に対する放射線・化学療法と救済的根治術による治療成績

木村康利, 今村将史, 及能大輔, 石井雅之, 目黒誠, 川本雅樹, 水口徹, 古畑智久, 平田公一

日本肝胆膵外科学会・学術集会プログラム・抄録集 25回 265 - 265 2013.6

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PS-059-3 切除可能大腸癌術後肝単独転移症例に対する術前化学療法の意義に関する検討(PS ポスターセッション,第113回日本外科学会定期学術集会)

沖田憲司, 古畑智久, 西舘敏彦, 原田敬介, 川本雅樹, 目黒誠, 今村将史, 前佛均, 信岡隆幸, 木村康利, 水口徹, 秦史壮, 佐々木一晃, 平田公一

日本外科学会雑誌 114 ( 2 ) 2013.3

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分子標的剤併用術前化学療法を施行し,完全切除可能であった局所進行初発直腸癌,再発直腸癌3例の報告.

村上武志, 古畑智久, 沖田憲司, 伊東竜哉, 中野正一郎, 信岡隆幸, 木村康利, 水口徹, 平田公一

日本大腸こう門病学会雑誌 66 ( 3 ) 201 2013.3

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分子生物学的手法を用いた肝細胞癌治療戦略肝細胞癌における細胞外マトリックスの分子環境ラミニンα鎖と受容体ルテランによる分子機序

水口徹, 吉川大和, 谷水直樹, 一戸義久, 中村幸雄, 川本雅樹, 目黒誠, 野水基義, 三高俊広, 平田公一

日本外科学会雑誌 114 ( 臨増2 ) 242 - 242 2013.3

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胆膵外科診療における癌救急

木村康利, 今村将史, 及能大輔, 石井雅之, 川本雅樹, 目黒誠, 水口徹, 古畑智久, 平田公一

日本腹部救急医学会雑誌 33 ( 2 ) 379 - 379 2013.2

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合同シンポジウム2-5 がんワクチン創薬への道程：がん抗原の同定から臨床試験まで

鳥越俊彦, 廣橋良彦, 塚原智英, 島宏彰, 水口徹, 平田公一, 佐藤昇志

日本臨床免疫学会会誌 36 ( 5 ) 313 - 313 2013

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我々は過去20年以上にわたってヒトがん抗原の同定とそれに対する免疫応答の分子機構を解明し，Survivinをはじめとする10種類以上のヒトがん抗原とそのHLA class I拘束性T細胞エピトープの構造を明らかにしてきた．抗原ペプチドを用いて患者の末梢血リンパ球を刺激すると，ペプチド特異的細胞障害性T細胞が誘導される．平成14年度からSVN-2Bペプチドワクチンの臨床試験を開始．平成23年度からは医師主導治験を実施している．Tetramerを用いた免疫モニタリングの結果，ペプチド特異的T細胞の頻度と抗腫瘍効果との間に相関性が見出された．また，インターフェロンの併用によって臨床効果が増強することが判明した．10月には進行膵臓がんに対する第2相試験（二重盲検試験）をスタートする．一方で我々は，ヒトの固形腫瘍細胞株からがん幹細胞（CSC）を分離することに成功し，現在CSC特異抗原の探索を実施している．がん幹細胞は，長寿命・高い造腫瘍能力・高い遊走能・抗がん剤耐性などの特性を有することから，がん再発と転移の根幹をなす細胞であると推察されている．CSC特異抗原はどのような分子か，CSC特異的細胞障害性T細胞の誘導とCSC標的治療モデル等を紹介し，がん幹細胞標的ワクチン創薬に向けての歩みと展望についても議論したい．

DOI： 10.2177/jsci.36.313

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Survivin2Bペプチドを用いた進行再発消化器癌に対するSUCCESS試験の途中経過

水口徹, 島宏彰, 鳥越俊彦, 九冨五郎, 下館広慎, 島田圭規, 林宏至, 稲毛富士郎, 杉田修, 朝倉純代, 佐藤昇志, 平田公一

日本外科系連合学会誌 38 ( 3 ) 2013

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大腸癌転移性肝転移の術前化学療法症例の検討

西舘敏彦, 古畑智久, 沖田憲司, 植木知身, 秋月恵美, 伊東竜哉, 信岡隆幸, 木村康利, 水口徹, 平田公一

大腸癌研究会プログラム・抄録集 79th 70 2013

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ステージ4腹腔鏡下大腸癌手術症例の検討

西舘敏彦, 古畑智久, 沖田憲司, 植木知身, 秋月恵美, 伊東竜哉, 目黒誠, 信岡隆幸, 木村康利, 水口徹, 秦史壮, 佐々木一晃, 平田公一

日本癌治療学会学術集会(CD-ROM) 51st ROMBUNNO.O62-1 2013

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【がん関連データベース、その特徴と今後の展開】がん登録を指標とした「がん診療ガイドライン」の普及と評価を目指して

平田公一, 沖田憲司, 今村将史, 太田盛道, 久木田和晴, 及能大輔, 水口徹, 古畑智久

Surgery Frontier 19 ( 4 ) 413 - 420 2012.12

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当科における進行大腸癌に対する腹腔鏡補助下大腸切除術

古畑智久, 沖田憲司, 西舘敏彦, 伊東竜哉, 山口洋志, 小川宰司, 信岡隆幸, 石井雅之, 木村康利, 水口徹, 佐々木一晃, 平田公一

日本臨床外科学会雑誌 73 453 2012.10

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A case of double cholangiolocellular carcinoma and hepatocellular carcinoma complicated with non-alcoholic steatohepatitis

KAWANO Yutaka, KIKUCHI Shohei, MIYANISHI Koji, NAGASHIMA Hiroyuki, HIRAKAWA Masahiro, TAMURA Fumito, YOSHIDA Makoto, TAKAHASHI Sho, TAKADA Kohichi, HAYASHI Tsuyoshi, SATO Tsutomu, SATO Yasushi, TAKIMOTO Risyu, KOBUNE Masayoshi, KAWAMOTO Masaki, MIZUGUCHI Toru, HIRATA Koichi, HASEGAWA Tadashi, KATO Junji

Kanzo 53 ( 10 ) 615 - 623 2012.10

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DOI： 10.2957/kanzo.53.615

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【EMTのUP DATE】特集によせて epithelial-mesenchymal transition(EMT)とは

平田公一, 及能大輔, 太田盛道, 島宏彰, 九冨五郎, 木村康利, 水口徹

Surgery Frontier 19 ( 3 ) 253 - 259 2012.9

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肝細胞癌における細胞接着分子Lutheran/B-CAMの発現とシェディング(Shedding of Luthern/basal cell adhesion molecule (Lu/B-CAM) from hepatocellular carcinoma)

吉川大和, 水口徹, 平田公一, 野水基義, 三高俊広

日本癌学会総会記事 71回 484 - 484 2012.8

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Luminalタイプの抗癌剤感受性と長期予後

鈴木やすよ, 水口徹, 岡崎稔, 高丸智子, 大村東生, 島宏彰, 九冨五郎, 里見蕗乃, 平田公一

日本乳癌学会総会プログラム抄録集 20回 301 - 301 2012.5

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【癌化学療法のエビデンス】膵癌

平田公一, 木村康利, 今村将史, 川本雅樹, 中村幸雄, 及能大輔, 久木田和晴, 太田盛道, 水口徹

消化器外科 35 ( 6 ) 987 - 996 2012.5

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PS-081-5 大腸切除における創感染のリスクファクターとその対策(PS-081 大腸周術期管理-1,ポスターセッション,第112回日本外科学会定期学術集会)

沖田憲司, 古畑智久, 西舘敏彦, 伊東竜哉, 原田敬介, 今村将史, 目黒誠, 信岡隆幸, 木村康利, 水口徹, 秦史壮, 佐々木一晃, 平田公一

日本外科学会雑誌 113 ( 2 ) 2012.3

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PS-069-2 腹腔鏡下補助下噴門側胃切除後の間置空腸嚢再建と機能評価(PS-069 胃鏡視下-1,第112回日本外科学会定期学術集会)

原田敬介, 信岡隆幸, 斎藤慶太, 橋本亜紀, 中野正一郎, 山口浩司, 傳野隆一, 木村康利, 水口徹, 古畑智久, 平田公一

日本外科学会雑誌 113 ( 2 ) 2012.3

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SF-110-3 切除不能・再発胃癌に対するDocetaxel/CDDP/S-1(DCS)療法と外科手術の位置づけ(SF-110 サージカルフォーラム(110)胃集学的治療,第112回日本外科学会定期学術集会)

信岡隆幸, 原田敬介, 斎藤慶太, 橋本亜紀, 中野正一郎, 木村康利, 水口徹, 古畑智久, 佐藤康史, 加藤淳二, 平田公一

日本外科学会雑誌 113 ( 2 ) 2012.3

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PS-144-7 肝細胞移植の展望(PS-144 肝基礎-3,ポスターセッション,第112回日本外科学会定期学術集会)

中村幸雄, 水口徹, 川本雅樹, 太田盛道, 目黒誠, 信岡隆幸, 木村康利, 古畑智久, 平田公一, 谷水直樹, 三高俊広, 村田雅樹, 沢田典均

日本外科学会雑誌 113 ( 2 ) 2012.3

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PS-125-1 術前化学療法施行進行胃癌における術後栄養補助療法の有用性(PS-125 胃周術期-1,ポスターセッション,第112回日本外科学会定期学術集会)

齋藤慶太, 信岡隆幸, 原田敬介, 巽博臣, 橋本亜紀, 中野誠一郎, 木村康利, 水口徹, 古畑智久, 平田公一

日本外科学会雑誌 113 ( 2 ) 2012.3

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遺伝子発現プロファイルに基づく乳がん術前化学療法感受性予測システムの構築

鈴木やすよ, 水口徹, 西舘敏彦, 植木知身, 里見蕗乃, 高丸智子, 九富五郎, 島宏彰, 大村東生, 鬼原史, 平田公一

日本外科学会雑誌 113 ( 臨増2 ) 444 - 444 2012.3

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膵の縮小手術その適応と問題点膵頭部縮小手術の手技と問題点

木村康利, 今村将史, 目黒誠, 三浦亮, 及能大輔, 伊東竜哉, 水口徹, 古畑智久, 平田公一

日本外科学会雑誌 113 ( 臨増2 ) 172 - 172 2012.3

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当科における下部消化管手術後の静脈血栓塞栓症対策

山口洋志, 古畑智久, 沖田憲司, 西舘敏彦, 伊東竜哉, 信岡隆幸, 木村康利, 水口徹, 平田公一

日本腹部救急医学会雑誌 32 ( 2 ) 359 2012.2

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Clinicopathological characteristics of basal-type breast cancer

Kutomi G, Furuhata T, Otokozawa S, Mori M, Hirata K, Ohmura T, Satomi F, Takamaru T, Shima H, Kameshima H, Suzuki Y, Kimura Y, Mizuguchi T

Japan Journal of Molecular Tumor Marker Research 27 79 - 79 2012

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DOI： 10.11241/jsmtmr.27.79

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当科における大腸癌Stage4・CurB術後の予後と適切なサーベイランス方法に関する検討

沖田憲司, 古畑智久, 西舘敏彦, 伊東竜哉, 秋月恵美, 小川宰司, 山口洋志, 石井雅之, 目黒誠, 前佛均, 信岡隆幸, 木村康利, 水口徹, 佐々木一晃, 平田公一

日本癌治療学会学術集会(CD-ROM) 50th ROMBUNNO.PS1-168 2012

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他科との連携手術―知っておくべき最新の知識 III.婦人科との連携大腸癌の卵巣・子宮・腟浸潤

沖田憲司, 古畑智久, 西舘敏彦, 伊東竜哉, 信岡隆幸, 木村康利, 水口徹, 平田公一

外科 73 ( 13 ) 1455 - 1460 2011.12

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【緊急手術の適応と手術手技の実際】急性胆嚢炎・急性胆管炎

目黒誠, 木村康利, 今村将史, 及能大輔, 山口洋志, 秋月恵美, 伊東竜哉, 川本雅樹, 信岡隆幸, 水口徹, 平田公一

消化器外科 34 ( 11 ) 1589 - 1603 2011.10

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大腸癌手術後サーベイランスにおける血清CEA値測定の意義

古畑智久, 沖田憲司, 西舘敏彦, 山口洋志, 伊東竜哉, 信岡隆幸, 木村康利, 水口徹, 佐々木一晃, 平田公一

日本癌治療学会誌 46 ( 2 ) 477 2011.9

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IPMNを併存した通常型膵管癌の臨床像と病理組織学的特徴

木村康利, 今村将史, 奥谷浩一, 伊東竜哉, 及能大輔, 川本雅樹, 目黒誠, 水口徹, 平田公一

膵臓 26 ( 3 ) 395 - 395 2011.6

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PS-091-3 進行胃癌に対する術前Docetaxel/CDDP/S-1 (DCS)療法の治療成績(PS-091 ポスターセッション(91)胃:化学療法-3,第111回日本外科学会定期学術集会)

原田敬介, 信岡隆幸, 木村康利, 水口徹, 古畑智久, 佐藤康史, 加藤淳二, 山口浩司, 平田公一

日本外科学会雑誌 112 ( 1 ) 2011.5

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SF-083-1 Stage IV胃癌に対するDocetaxel/CDDP/S-1(DCS)療法後adjuvant surgeryの有用性(サージカルフォーラム(83)胃:化学療法,第111回日本外科学会定期学術集会)

信岡隆幸, 原田敬介, 秋月恵美, 及能大輔, 宇野智子, 木村康利, 水口徹, 古畑智久, 佐藤康史, 加藤淳二, 平田公一

日本外科学会雑誌 112 ( 1 ) 2011.5

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IPMNを併存した通常型膵管癌の臨床病理学的特徴

奥谷浩一, 木村康利, 今村将史, 伊東竜哉, 川本雅樹, 目黒誠, 水口徹, 古畑智久, 平田公一

日本外科学会雑誌 112 871 2011.5

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PS-207-2 肝切除後離断面膿瘍に関する検討(PS-207 ポスターセッション(207)肝臓:周術期管理-2,第111回日本外科学会定期学術集会)

川本雅樹, 水口徹, 目黒誠, 西舘敏彦, 原田敬介, 沖田憲司, 今村将史, 信岡隆幸, 木村康利, 古畑智久, 平田公一

日本外科学会雑誌 112 ( 1 ) 2011.5

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【StageIV胃癌治療への挑戦】 StageIV胃癌に対する積極的化学療法後の胃切除の安全性

信岡隆幸, 原田敬介, 及能大輔, 三浦亮, 木村康利, 水口徹, 佐藤康史, 加藤淳二, 平田公一

消化器外科 34 ( 5 ) 559 - 567 2011.5

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Stage IV胃癌に対するDocetaxel/CDDP/S-1(DCS)療法後adjuvant surgeryの有用性

信岡隆幸, 原田敬介, 秋月恵美, 及能大輔, 宇野智子, 木村康利, 水口徹, 古畑智久, 佐藤康史, 加藤淳二, 平田公一

日本外科学会雑誌 112 ( 臨増1-2 ) 439 - 439 2011.5

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Docetaxel+Cisplatin+S-1併用術前補助化学療法が著効した進行胃癌の1例

信岡隆幸, 原田敬介, 秋月恵美, 及能大輔, 宇野智子, 木村康利, 水口徹, 古畑智久, 佐藤康史, 加藤淳二, 平田公一

日本胃癌学会総会記事 83回 287 - 287 2011.3

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A case of pancreatic foreign-body granulation tissue showed stenosis of the main pancreatic duct

SON Seiichi, KIMURA Yasutoshi, NAGAYAMA Minoru, KONNO Ai, IMAMURA Masafumi, MIZUGUCHI Toru, FURUHATA Tomohisa, NAKANISHI Katsuya, NAGAKAWA Tatsuya, HASEGAWA Tadashi, HIRATA Koichi

26 ( 1 ) 91 - 98 2011.2

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Laparoscopic Hepatectomy: A Systematic Review, Meta-Analysis, and Power Analysis

Toru Mizuguchi, Masaki Kawamoto, Makoto Meguro, Toshihito Shibata, Yukio Nakamura, Yasutoshi Kimura, Tomohisa Furuhata, Tomoko Sonoda, Koichi Hirata

SURGERY TODAY 41 ( 1 ) 39 - 47 2011.1

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DOI： 10.1007/s00595-010-4337-6

Web of Science

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進行胃癌術前化学療法施行症例に対する周術期管理の実際

信岡隆幸, 原田敬介, 巽博臣, 秋月恵美, 宇野智子, 及能大輔, 木村康利, 水口徹, 古畑智久, 川崎喜恵子, 山口浩司, 平田公一

静脈経腸栄養 26 ( 1 ) 377 - 377 2011.1

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遺伝性出血性血管拡張症(Osler病)を合併した悪性黒色腫胃転移に対しLECSを施行した1例

宇野智子, 信岡隆幸, 原田敬介, 秋月恵美, 及能大輔, 木村康利, 水口徹, 古畑智久, 平田公一

北海道外科雑誌 55 ( 2 ) 166 - 166 2010.12

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がんの分子機構解明から臨床応用へ肝細胞癌の細胞外マトリックス環境異所的なラミニンα5鎖とその受容体ルテランによる細胞接着の解明

吉川大和, 谷水直樹, 水口徹, 平田公一, 三高俊広, 野水基義

日本生化学会大会・日本分子生物学会年会合同大会講演要旨集 83回・33回 2W21 - p 2010.12

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胸腔鏡下核出術を行った食道平滑筋腫の1例

宇野智子, 信岡隆幸, 原田敬介, 秋月恵美, 及能大輔, 木村康利, 水口徹, 古畑智久, 平田公一

日本臨床外科学会雑誌 71 ( 10 ) 2733 - 2733 2010.10

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胸腔鏡下手術により切除した食道平滑筋腫の1例

信岡隆幸, 原田敬介, 秋月恵美, 及能大輔, 宇野智子, 西舘敏彦, 木村康利, 水口徹, 古畑智久, 平田公一

日本内視鏡外科学会雑誌 15 ( 7 ) 564 - 564 2010.10

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【エキスパートに学ぶ胃切除後の再建法】噴門側胃切除術空腸嚢間置術

信岡隆幸, 原田敬介, 宇野智子, 及能大輔, 木村康利, 水口徹, 古畑智久, 川崎喜恵子, 平田公一

消化器外科 33 ( 11 ) 1739 - 1746 2010.10

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遺伝性出血性血管拡張症(Osler病)を合併した悪性黒色腫胃転移に対しLECSを施行した1例

宇野智子, 信岡隆幸, 原田敬介, 秋月恵美, 及能大輔, 木村康利, 水口徹, 古畑智久, 平田公一

日本臨床外科学会雑誌 71 ( 増刊 ) 832 - 832 2010.10

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診断に苦慮した胃癌と乳癌の同時性重複癌の1例

宇野智子, 信岡隆幸, 原田敬介, 及能大輔, 木村康利, 水口徹, 古畑智久, 佐藤康史, 加藤淳二, 平田公一

日本癌治療学会誌 45 ( 2 ) 782 - 782 2010.9

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mFOLFOX6+ベバシズマブによる術前化学療法が著効した進行大腸癌の1例

山口洋志, 古畑智久, 沖田憲司, 西舘敏彦, 久木田和晴, 及能大輔, 川本雅樹, 目黒誠, 水口徹, 平田公一

日本癌治療学会誌 45 ( 2 ) 562 - 562 2010.9

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腹腔鏡下直腸切断術施行時の腹膜外経路人工肛門造設法

西舘敏彦, 古畑智久, 沖田憲司, 山口洋志, 及能大輔, 久木田和晴, 原田敬介, 川本雅樹, 目黒誠, 今村将史, 永山稔, 信岡隆幸, 木村康利, 水口徹, 秦史壮, 佐々木一晃, 平田公一

日本大腸肛門病学会雑誌 63 ( 9 ) 611 - 611 2010.9

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切除不能大腸癌に対する3次治療以降でのセツキシマブの使用経験

河野剛, 古畑智久, 沖田憲司, 西舘敏彦, 及能大輔, 信岡隆幸, 木村康利, 水口徹, 佐々木一晃, 平田公一

日本消化器外科学会総会 65回 53 - 53 2010.7

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大腸癌肝転移に対する計画的術前化学療法の安全性と効果の検討

西舘敏彦, 古畑智久, 沖田憲司, 久木田和晴, 及能大輔, 目黒誠, 川本雅樹, 木村康利, 水口徹, 平田公一

日本消化器外科学会総会 65回 178 - 178 2010.7

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大動脈周囲リンパ節転移陽性胃癌に対する術前Docetaxel/CDDP/S-1(DCS)療法の治療成績

原田敬介, 信岡隆幸, 山口浩司, 及能大輔, 木村康利, 水口徹, 古畑智久, 平田公一, 佐藤康史, 加藤淳二

日本消化器外科学会総会 65回 666 - 666 2010.7

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進行胃癌に対する術前Docetaxel+Cisplatin+S-1(DCS)併用化学療法

信岡隆幸, 原田敬介, 及能大輔, 木村康利, 水口徹, 古畑智久, 佐藤康史, 加藤淳二, 山口浩司, 平田公一

日本消化器外科学会総会 65回 22 - 22 2010.7

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当科における人工肛門閉鎖術の術後表層SSIの危険因子に関する検討

及能大輔, 古畑智久, 沖田憲司, 西舘敏彦, 信岡隆幸, 木村康利, 水口徹, 秦史壮, 佐々木一晃, 平田公一

日本消化器外科学会総会 65回 412 - 412 2010.7

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胃粘膜下腫瘍に対する腹腔鏡(補助)下手術の経験

及能大輔, 信岡隆幸, 原田敬介, 里見蕗乃, 山口浩司, 木村康利, 水口徹, 古畑智久, 平田公一

北海道外科雑誌 55 ( 1 ) 22 - 26 2010.6

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胃GISTに対してLECSを施行した1例

及能大輔, 信岡隆幸, 原田敬介, 里見蕗乃, 古畑智久, 水口徹, 木村康利, 平田公一, 山下健太郎, 有村佳明, 篠村恭久

北海道外科雑誌 55 ( 1 ) 59 - 59 2010.6

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スニチニブ投与中の肝・肺転移を伴う胃GISTに対する手術経験

及能大輔, 信岡隆幸, 原田敬介, 里見蕗乃, 木村康利, 水口徹, 古畑智久, 奥田博介, 山下健太郎, 有村佳明, 篠村恭久, 平田公一

日本臨床外科学会雑誌 71 ( 5 ) 1369 - 1369 2010.5

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消化管に対する鏡視下手術の工夫腹腔鏡下直腸癌手術を安全に行うための我々の工夫助手の役割

西舘敏彦, 古畑智久, 沖田憲司, 久木田和磨, 及能大輔, 原田敬介, 川本雅樹, 目黒誠, 今村将史, 信岡隆幸, 木村康利, 水口徹, 秦史壮, 佐々木一晃, 平田公一

日本外科系連合学会誌 35 ( 3 ) 460 - 460 2010.5

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FOLFOX+アバスチンが有効であった進行大腸癌の一例

久木田和晴, 古畑智久, 沖田憲司, 西舘敏彦, 及能大輔, 川本正樹, 目黒誠, 原田敬介, 信岡隆幸, 木村康利, 水口徹, 平田公一

日本臨床外科学会雑誌 71 ( 5 ) 1364 - 1365 2010.5

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DOI： 10.3919/jjsa.71.1364

Ichushi

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Reconsideration of the Severity Assessment of Acute Cholangitis from the Perspective of Organ Dysfunction and the Prognosis

KIMURA Yasutoshi, NAGAYAMA Minoru, IMAMURA Masafumi, AKIZUKI Emi, MEGURO Makoto, OKITA Kenji, KAWAMOTO Masaki, HARADA Keisuke, NISHIDATE Toshihiko, NOBUOKA Takayuki, MIZUGUCHI Toru, FURUHATA Tomohisa, HIRATA Koichi

30 ( 3 ) 449 - 454 2010.3

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DOI： 10.11231/jaem.30.449

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VD-015-5 当科における腹腔鏡補助下肝切除術 : 適応拡大と系統的切除の確立へ向けて(鏡視下手術・肝-1,一般ビデオ,第110回日本外科学会定期学術集会)

川本雅樹, 水口徹, 目黒誠, 久木田和晴, 永山稔, 西舘敏彦, 原田敬介, 沖田憲司, 今村将史, 信岡隆幸, 木村康利, 古畑智久, 平田公一

日本外科学会雑誌 111 ( 2 ) 2010.3

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PD-7-9 Stage IV胃癌に対する集学的治療の治療成績 : 術前Docetaxel/CDDP/S-1 (DCS)療法+手術の有効性(Stage IV胃癌における外科治療の有用性,パネルディスカッション,第110回日本外科学会定期学術集会)

原田敬介, 信岡隆幸, 山口浩司, 木村康利, 水口徹, 古畑智久, 佐藤康史, 加藤淳二, 平田公一

日本外科学会雑誌 111 ( 2 ) 2010.3

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WS-7-9 教室における噴門側胃切除後空腸嚢間置再建術式の変遷と術後機能評価(胃癌術後QOL向上に役立つ手技・再建法とその機能的評価,ワークショップ(7),第110回日本外科学会定期学術集会)

信岡隆幸, 原田敬介, 里見蕗乃, 木村康利, 水口徹, 古畑智久, 山口浩司, 平田公一

日本外科学会雑誌 111 ( 2 ) 2010.3

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当科におけるセツキシマブ使用6症例の使用経験

及能大輔, 古畑智久, 沖田憲司, 西舘敏彦, 目黒誠, 信岡隆幸, 木村康利, 水口徹, 秦史壮, 佐々木一晃, 平田公一

日本大腸肛門病学会雑誌 63 ( 3 ) 188 - 188 2010.3

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肝・肺転移を伴うSunitinib投与胃GISTに対する手術経験

原田敬介, 信岡隆幸, 及能大輔, 里見蕗乃, 木村康利, 水口徹, 古畑智久, 奥田博介, 山下健太郎, 有村佳昭, 篠村恭久, 平田公一

日本胃癌学会総会記事 82回 367 - 367 2010.3

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胃粘膜下腫瘍に対する腹腔鏡下胃局所切除術 laparoscopy endoscopy cooperative surgeryの導入

信岡隆幸, 原田敬介, 及能大輔, 里見蕗乃, 木村康利, 水口徹, 古畑智久, 山口浩司, 平田公一

日本胃癌学会総会記事 82回 321 - 321 2010.3

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当科における大腸癌肺転移症例の予後に関する検討

及能大輔, 古畑智久, 沖田憲司, 西舘敏彦, 目黒誠, 信岡隆幸, 木村康利, 水口徹, 平田公一, 秦史壮, 佐々木一晃

日本臨床外科学会雑誌 71 ( 3 ) 865 - 865 2010.3

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腹腔鏡下修復術を行なった横隔膜ヘルニアの1例

原田敬介, 信岡隆幸, 及能大輔, 里見蕗乃, 木村康利, 水口徹, 古畑智久, 平田公一

日本腹部救急医学会雑誌 30 ( 2 ) 379 - 379 2010.2

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Summarized Review of the Clinical Guideline of Acute Pancreatitis (Third Edition): Changes in the new assessment of severity and diagnostic criteria

HIRATA KOICHI, KIMURA YASUTOSHI, NOBUOKA TAKAYUKI, YAMAGUCHI HIROSHI, ITO TATSUYA, KAWAMOTO MASAKI, IMAMURA MASASHI, NAGAYAMA MINORU, AKIZUKI EMI, NARITA AKANE, YAMAYA YORIKO, MIZUGUCHI TOORU, FURUHATA TOMOHISA

日本救急医学会雑誌 21 ( 1 ) 1 - 18 2010.1

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DOI： 10.3893/jjaam.21.1

J-GLOBAL

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膀胱浸潤大腸癌切除症例の臨床病理学的検討と治療成績

及能大輔, 古畑智久, 沖田憲司, 西舘敏彦, 目黒誠, 原田敬介, 信岡隆幸, 木村康利, 水口徹, 平田公一, 秦史壮, 佐々木一晃

北海道外科雑誌 54 ( 2 ) 156 - 156 2009.12

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腹腔鏡補助下低位前方切除後に発生した内ヘルニアの1例

西舘敏彦, 古畑智久, 沖田憲司, 及能大輔, 目黒誠, 原田敬介, 川本正樹, 今村将史, 永山稔, 信岡隆幸, 木村康利, 水口徹, 平田公一

日本内視鏡外科学会雑誌 14 ( 7 ) 487 - 487 2009.12

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直腸癌手術における腹腔鏡下側方リンパ節郭清術

古畑智久, 沖田憲司, 西舘敏彦, 及能大輔, 信岡隆幸, 原田敬介, 目黒誠, 木村康利, 水口徹, 秦史壮, 佐々木一晃, 平田公一

日本内視鏡外科学会雑誌 14 ( 7 ) 309 - 309 2009.12

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人工肛門閉鎖術における環状皮膚縫合法の有用性

沖田憲司, 古畑智久, 西舘敏彦, 及能大輔, 目黒誠, 原田敬介, 信岡隆幸, 木村康利, 水口徹, 平田公一

日本ストーマ・排泄リハビリテーション学会誌 25 ( 3 ) 220 - 220 2009.12

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当科における腹腔鏡下直腸手術症例の検討

沖田憲司, 古畑智久, 西舘敏彦, 及能大輔, 原田敬介, 目黒誠, 信岡隆幸, 木村康利, 水口徹, 秦史壮, 佐々木一晃, 平田公一

日本内視鏡外科学会雑誌 14 ( 7 ) 306 - 306 2009.12

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一時的人工肛門閉鎖術の皮膚縫合法の検討

西舘敏彦, 古畑智久, 沖田憲司, 及能大輔, 河野剛, 目黒誠, 永山稔, 木村康利, 水口徹, 平田公一

日本外科感染症学会雑誌 6 ( 5 ) 540 - 540 2009.11

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術者と助手の協調操作による安全な腹腔鏡下大腸切除術

西舘敏彦, 古畑智久, 沖田憲司, 及能大輔, 目黒誠, 川本正樹, 今村将史, 永山稔, 信岡隆幸, 原田敬介, 木村康利, 水口徹, 秦史壮, 佐々木一晃, 平田公一

日本臨床外科学会雑誌 70 ( 増刊 ) 462 - 462 2009.10

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腹腔鏡補助下低位前方切除術における手技上の工夫

古畑智久, 沖田憲司, 西舘敏彦, 及能大輔, 信岡隆幸, 原田敬介, 川本雅樹, 永山稔, 今村将史, 木村康利, 目黒誠, 水口徹, 秦史壮, 佐々木一晃, 平田公一

日本臨床外科学会雑誌 70 ( 増刊 ) 480 - 480 2009.10

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化学療法のための上腕部留置ポートの導入

沖田憲司, 古畑智久, 西舘敏彦, 及能大輔, 河野剛, 川本雅樹, 目黒誠, 信岡隆幸, 木村康利, 水口徹, 秦史壮, 佐々木一晃, 平田公一

日本臨床外科学会雑誌 70 ( 増刊 ) 418 - 418 2009.10

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下部消化管術後手術創感染における危険因子の検討

及能大輔, 古畑智久, 沖田憲司, 西舘敏彦, 目黒誠, 信岡隆幸, 木村康利, 水口徹, 秦史壮, 佐々木一晃, 平田公一

日本臨床外科学会雑誌 70 ( 増刊 ) 999 - 999 2009.10

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進行直腸癌に対する腹腔鏡補助下手術の取り組み

古畑智久, 沖田憲司, 西舘敏彦, 及能大輔, 河野剛, 原田敬介, 信岡隆幸, 川本雅樹, 今村将史, 永山稔, 木村康利, 水口徹, 佐々木一晃, 平田公一

日本癌治療学会誌 44 ( 2 ) 834 - 834 2009.9

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大腸癌再発時血清CEA値と再発後の予後の関連に関する検討

沖田憲司, 古畑智久, 西舘敏彦, 及能大輔, 目黒誠, 木村康利, 水口徹, 秦史壮, 佐々木一晃, 平田公一

日本癌治療学会誌 44 ( 2 ) 443 - 443 2009.9

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切除可能な大腸癌肝転移症例に対しての肝切除術前後化学療法の治療成績

西舘敏彦, 古畑智久, 沖田憲司, 及能大輔, 川本雅樹, 目黒誠, 今村将史, 永山稔, 信岡隆幸, 木村康利, 水口徹, 平田公一

日本癌治療学会誌 44 ( 2 ) 894 - 894 2009.9

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EFFECT OF FOOD ON THE ORAL BIOAVAILABILITY OF UFT AND LEUCOVORIN IN JAPANESE COLORECTAL CANCER PATIENTS

T. Furuhata, T. Nishidate, M. Meguro, K. Okita, G. Ishiyama, Y. Kimura, T. Mizuguchi, K. Sasaki, Y. Hosokawa, K. Hirata

ANNALS OF ONCOLOGY 19 135 - 135 2008.9

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Web of Science

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O-1-310 胆嚢癌治癒切除症例の術式と予後の検討(胆嚢悪性2,一般演題(口演),第63回日本消化器外科学会総会)

永山稔, 木村康利, 今野愛, 信岡隆幸, 今村将史, 水口徹, 古畑智久, 平田公一

日本消化器外科学会雑誌 41 ( 7 ) 1191 2008.7

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CiNii Research

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PD-3-3 手術症例数からみた肝胆膵外科医育成のための取り組み(パネルディスカッション3 こうする,こうしてほしい消化器外科領域の教育体制-肝・胆・膵-,第63回日本消化器外科学会総会)

今村将史, 木村康利, 永山稔, 今野愛, 信岡隆幸, 水口徹, 古畑智久, 平田公一

日本消化器外科学会雑誌 41 ( 7 ) 1030 2008.7

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PD-4-3 膵頭十二指腸切除術後の胃内容排出遅延発生に切除術式・再建方法は如何に関与しているのか?(パネルディスカッション4 最新の消化器外科領域の術後障害に対する対策,第63回日本消化器外科学会総会)

秋月恵美, 木村康利, 永山稔, 信岡隆幸, 西舘敏彦, 今野愛, 今村将史, 水口徹, 古畑智久, 平田公一

日本消化器外科学会雑誌 41 ( 7 ) 1033 2008.7

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O-1-292 当科における小膵癌(ts1)症例の検討(膵悪性,一般演題(口演),第63回日本消化器外科学会総会)

今野愛, 木村康利, 永山稔, 秋月恵美, 水口徹, 古畑智久, 平田公一

日本消化器外科学会雑誌 41 ( 7 ) 1189 2008.7

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維持透析患者に対する安全な肝切除術と周術期管理 1症例検討

太田盛道, 水口徹, 永山稔, 信岡隆幸, 木村康利, 宮西浩嗣, 河野豊, 山口浩司, 古畑智久, 新津洋司郎, 平田公一

北海道外科雑誌 53 ( 1 ) 63 - 68 2008.6

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血液透析施行中患者に対し安全に肝切除を施行し得た1例

太田盛道, 水口徹, 永山稔, 信岡隆幸, 木村康利, 山口浩司, 古畑智久, 平田公一, 宮西浩嗣, 河野豊, 新津洋司郎

北海道外科雑誌 52 ( 2 ) 190 - 190 2007.12

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How to manage pancreatic cancer patients during and after potentially curative resection?

Yasutoshi Kimura, Takayuki Nobuoka, Keisuke Ohno, Emi Akizuki, Toru Mizuguchi, Tomohisa Furuhata

JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY 22 A52 - A52 2007.10

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A novel molecular marker of pituitary tumor transforming gene involves in a rat liver regeneration

K Akino, S Akita, T Mizuguchi, Takumi, I, R Yu, XY Wang, J Rozga, AA Demetriou, S Melmed, A Ohtsuru, S Yamashita

JOURNAL OF SURGICAL RESEARCH 129 ( 1 ) 142 - 146 2005.11

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DOI： 10.1016/j.jss.2005.04.019

Web of Science

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緊急手術を要した稀な急性胆嚢疾患の2切除例

井上大成, 木村康利, 信岡隆幸, 藤兼智子, 水口徹, 桂巻正, 平田公一

日本臨床外科学会雑誌 66 ( 増刊 ) 688 - 688 2005.10

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非閉塞性腸管虚血症(NOMI)による広範な腸管壊死を伴った重症急性膵炎の一例

信岡隆幸, 木村康利, 井上大成, 藤兼智子, 水口徹, 桂巻正, 平田公一

日本臨床外科学会雑誌 66 ( 増刊 ) 630 - 630 2005.10

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Language：Japanese Publisher：日本臨床外科学会

Ichushi

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膵管胆道合流異常症・膵癒合不全に総肝管隔壁形成を伴った一例

秋月恵美, 木村康利, 信岡隆幸, 井上大成, 藤兼智子, 水口徹, 桂巻正, 平田公一

日本膵管胆道合流異常研究会プロシーディングス 28回 62 - 63 2005.10

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Language：Japanese Publisher：日本膵・胆管合流異常研究会

Ichushi

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膵管胆道合流異常症・膵癒合不全に総肝管隔壁形成を伴った一例

藤兼智子, 木村康利, 信岡隆幸, 井上大成, 水口徹, 桂巻正, 宮西浩嗣, 林毅, 石渡裕俊, 平田公一

日本臨床外科学会雑誌 66 ( 9 ) 2347 - 2347 2005.9

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Language：Japanese Publisher：日本臨床外科学会

Ichushi

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十二指腸乳頭部癌とカルチノイドを合併したCholedochoceleの1例

井上大成, 木村康利, 信岡隆幸, 藤兼智子, 水口徹, 桂巻正, 遠藤高夫, 阿部環, 岡俊州, 平田公一

日本臨床外科学会雑誌 66 ( 9 ) 2348 - 2348 2005.9

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Language：Japanese Publisher：日本臨床外科学会

Ichushi

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Hand-assisted laparoscopic pylorus-preserving pancreaticoduodenectomy for pancreas head disease

Y Kimura, K Hirata, M Mukaiya, T Mizuguchi, K Koito, T Katsuramaki

AMERICAN JOURNAL OF SURGERY 189 ( 6 ) 734 - 737 2005.6

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Language：English

DOI： 10.1016/j.amjsurg.2005.03.017

Web of Science

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Biliary injury after laparoscopic cholecystectomy: end-to-end anastomosis covered with umbilical vein

Y Kimura, K Hirata, M Mukaiya, T Mizuguchi, T Nobuoka, T Furuhata, T Katsuramaki

JOURNAL OF HEPATO-BILIARY-PANCREATIC SURGERY 12 ( 3 ) 269 - 271 2005

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Language：English

DOI： 10.1007/s00534-004-0968-6

PubMed

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Growth of hepatic angiomyolipoma indicating malignant potential

T Mizuguchi, T Katsuramaki, T Nobuoka, A Nishikage, H Oshima, H Kawasaki, S Kimura, M Satoh, K Hirata

JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY 19 ( 11 ) 1328 - 1330 2004.11

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Language：English Publishing type：Rapid communication, short report, research note, etc. (scientific journal)

DOI： 10.1111/j.1400-1746.2004.03583.x

Web of Science

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Endo-bowel clamp (PL540S) for safe rectal irrigation in laparoscopy-assisted rectal resection

T Furuhata, F Hata, T Tsuruma, H Nishimori, K Yamaguchi, T Mizuguchi, Y Kimura, T Katsuramaki, M Mukaiya, K Sasaki, K Hirata

SURGERY TODAY 34 ( 10 ) 882 - 884 2004.10

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Language：English

DOI： 10.1007/s00595-004-2838-x

Web of Science

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Serum hyaluronate level for predicting subclinical liver dysfunction after hepatectomy

T Mizuguchi, T Katsuramaki, T Nobuoka, M Kawamoto, H Oshima, H Kawasaki, H Kikuchi, C Shibata, K Hirata

WORLD JOURNAL OF SURGERY 28 ( 10 ) 971 - 976 2004.10

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Language：English

DOI： 10.1007/s00268-004-7389-1

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Significance of combined spiral 3-D computed tomography angiogram and pneumocolon for primary mesenteric stromal tumor

T Mizuguchi, T Katsuramaki, T Nobuoka, T Hirano, T Ichimura, H Maeda, H Kawasaki, K Koito, K Hirata

JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY 19 ( 8 ) 946 - 948 2004.8

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Language：English Publishing type：Rapid communication, short report, research note, etc. (scientific journal)

DOI： 10.1111/j.1440-1746.2004.03533.x

Web of Science

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Successful management of severe acute pancreatitis with multiple organ failure

T Mizuguchi, M Mukaiya, H Imaizumi, Y Kimura, Y Masuda, T Katsuramaki, Y Asai, K Hirata

PANCREAS 28 ( 2 ) 211 - 213 2004.3

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Language：English

DOI： 10.1097/00006676-200403000-00014

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Hepatectomy for hepatic metastasis from breast cancer

KATSURAMAKI Tadashi, MIZUGUCHI Touru, OHMURA Tousei, NAKAMURA Yukio, KIMURA Yasutoshi, HONMA Toshio, FURUHATA Tomohisa, MUKAIYA Mitsuhiro, SASAKI Kazuaki, HIRATA Koichi

J Jpn Surg Assoc 65 ( 9 ) 2304 - 2308 2004

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Language：Japanese Publisher：Japan Surgical Association

We report 8 cases of hepatectomy for hepatic metastases of breast cancer in the last 7 years. Patients were a mean 48.5±11.6 years old. Mean tumor diameter was 3.6 cm (2.2-6.0cm), with single tumors in 3 and multiple tumors in 5. Resections involved partial resection in 4, left lobectomy in 2, and extended subsegmentectomy and left lobectomy with right partial resection in 1 case each. No hospital deaths occurred. One-year survival was 87.5% and 3-year survival 33.3%. Three-year survival for single tumors was 66.7% and that for multiple tumors 0%. Significantly higher cumulative survival was noted in single-tumor cases (p<0.05). Recurrence in the remnant liver had a digmal prognosis, although recurrence in other organs had a comparatively better proguosis. In conclusion, hepatectomy of liver metastases from breast cancer maybe hopeful in patients with single tumors, but limited in efficacy in patients with multiple tumors.

DOI： 10.3919/jjsa.65.2304

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Clinical application and limitation of apheresis for fulminant hepatic failure.

Japanese J. Apheresis 22 213 - 218 2003

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劇症肝炎に対するアフェレシス治療の適応と限界.

日本アフェレシス学会雑誌 22 213 - 218 2003

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A case of intraductal cholangiocarcinoma with atypical multinodular image findings.

Nishikawa Noriko, Katsuramaki Tadashi, Mizuguchi Toru, Kimura Sachiko, Sasaki Aya, Nobuoka Takayuki, Nui Akihiro, Kimura Yasutoshi, Furuhata Tomohisa, Yamaguchi Koji, Hirata Koichi

Tumor Res. 38 13 - 16 2003

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Language：English Publisher：Sapporo Medical University

Other Link:： http://ir.cc.sapmed.ac.jp/dspace/handle/123456789/204

DOI： 10.15114/tr.38.13

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Regenerative Medicine and Embryonic Stem Cells - The Future of Epithelium Transplantation -

MIZUGUCHI Toru, HIRATA Koichi, HARADA Keisuke, MIYAMOTO Shigeki

22 ( 7 ) 1015 - 1021 2002.11

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Language：Japanese

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長期生存したstage4大腸癌症例の検討

水口徹, 佐々木一晃, 古畑智久, 泰史壮, 桂巻正, 高坂一, 平田公一

日本消化器外科学会雑誌 35 ( 7 ) 2002

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J-GLOBAL

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Enhanced proliferation and differentiation of rat hepatocytes cultured with bone marrow stromal cells

T Mizuguchi, T Hui, K Palm, N Sugiyama, T Mitaka, AA Demetriou, J Rozga

JOURNAL OF CELLULAR PHYSIOLOGY 189 ( 1 ) 106 - 119 2001.10

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Language：English

DOI： 10.1002/jcp.1136

PubMed

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Paper is a compatible bed for rat hepatocytes

T Mizuguchi, T Mitaka, F Sato, Y Mochizuki, K Hirata

ARTIFICIAL ORGANS 24 ( 4 ) 271 - 277 2000.4

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Language：English

DOI： 10.1046/j.1525-1594.2000.06506.x

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Alteration of expression of liver-enriched transcription factors in the transition between growth and differentiation of primary cultured rat hepatocytes

T Mizuguchi, T Mitaka, K Hirata, H Oda, Y Mochizuki

JOURNAL OF CELLULAR PHYSIOLOGY 174 ( 3 ) 273 - 284 1998.3

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Language：English

DOI： 10.1002/(SICI)1097-4652(199803)174:3<273::AID-JCP1>3.0.CO;2-L

PubMed

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Recovery of mRNA Expression of Tryptophan 2,3-Dioxygenase and Serine Dehydratase in Long-Term Cultures of Primary Rat Hepatocytes^1

MIZUGUCHI Toru, MITAKA Toshihiro, KOJIMA Takashi, HIRATA Koichi, NAKAMURA Toshikazu, MOCHIZUKI Yohichi

J Biochem 120 ( 3 ) 511 - 517 1996.9

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Language：English

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A case report: Progression and regression of biloma after laparoscopic cholecystectomy evaluated by computed tomography.

Int. Surg.

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9999

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Research Projects

The Web System and Prognostic Model for Mental Support of Critically Ill Patients and Families

Grant number：21K10715 2021.4 - 2024.3

Japan Society for the Promotion of Science Grants-in-Aid for Scientific Research Grant-in-Aid for Scientific Research (C)

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Grant amount：\4290000 （ Direct Cost: \3300000 、 Indirect Cost：\990000 ）

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Construction and implementation research of PRO and feedback system to clarify QOL value after surgery

Grant number：20K10404 2020.4 - 2023.3

Japan Society for the Promotion of Science Grants-in-Aid for Scientific Research Grant-in-Aid for Scientific Research (C)

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Grant amount：\4160000 （ Direct Cost: \3200000 、 Indirect Cost：\960000 ）

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Renewal of severely damaged livers by activating hepatic progenitor cells

Grant number：18H02873 2018.4 - 2021.3

Japan Society for the Promotion of Science Grants-in-Aid for Scientific Research Grant-in-Aid for Scientific Research (B)

MITAKA Toshihiro

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Grant amount：\17420000 （ Direct Cost: \13400000 、 Indirect Cost：\4020000 ）

Small hepatocytes (SHs) are a subpopulation of mature hepatocytes that can act as hepatocytic progenitor cells. Hepatocytic parental progenitor cells (HPPCs) exist among SHs. In this study we demonstrated that the self-renewal ability of HPPCs depended on laminin111 through integrin beta1 signaling. In addition, we succeeded in generating a hepatobiliary tubular organoid using mouse hepatocytic progenitor cells and cholangiocytes. Hepatocytes form the bile canalicular network and secret metabolites into the canaliculi, which are then transported into the biliary tubular structure.
Transplantation of bone marrow-derived mesenchymal cells (BM-MCs) enhanced the regeneration of retrorsine/PH (Ret/PH) model rat livers. Small hepatocyte-like progenitor cells (SHPCs) are intrinsic hepatic progenitor cells appeared in Ret/PH-treated livers. Administration of BM-MC-derived extracellular vesicles containing miR-146a-5p, interleukin 6, and stem cell factor could enhance the growth of SHPCs.

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Translational research for clinical apply using liver stem cells from cell banking

Grant number：17K10672 2017.4 - 2020.3

Japan Society for the Promotion of Science Grants-in-Aid for Scientific Research Grant-in-Aid for Scientific Research (C)

MIZUGUCHI TORU

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Grant amount：\4680000 （ Direct Cost: \3600000 、 Indirect Cost：\1080000 ）

We established a method to identify and separate liver stem cells from CD45-, TER119-, CD31-, EpCAM-negative, and ICAM-1-positive cells as donor cells for hepatocyte-transplantation. From this cell population, cloned liver stem cells were established. Besides, donor cells treated with oncostatin M had improved regeneration replacement efficiency. Twenty-five studies targeting liver volume assessment were collected and reviewed to improve donor collection efficiency. When projected on a three-dimensional scatter plot as a standard liver volume calculation method, it was found that it was classified into two clusters.
The involvement of the structural variant of laminin could be on the self-renewal performance of the parental progenitor cells. When hyaluronic acid was used as a substrate, CD44-positive small hepatocytes proliferated, and the cell recovery rate and the retransplantation rate were improved under the conditions using Matrigel as a substrate.

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Analysis of Intestinal disorder and liver damage resulting from cardiac arrest

Grant number：16K11413 2016.4 - 2020.3

Japan Society for the Promotion of Science Grants-in-Aid for Scientific Research Grant-in-Aid for Scientific Research (C)

Harada Keisuke

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Grant amount：\4550000 （ Direct Cost: \3500000 、 Indirect Cost：\1050000 ）

We established a rat model of intestinal ischemic injury with post cardiopulmonary arrest syndrome. We also evaluated the damage of intestine and liver cells after cardiopulomonary resuscitation. The cell damage induced by extracorporeal pulmonary resuscitation, which were found in intestinal mucosa, but were not found in hepatic tissue.
The mechanism of intestinal dysfunction induced by the short term of resuscitation, the change of hemodynamics and brain hypothermia therapy might also correlated with reperfusion injury after the cardiopulmonary arrest.

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肝切除術後肝不全予防のための術中ビジリオモニタリングによる新規管理法の開発

Grant number：26461920 2014.4 - 2017.3

日本学術振興会科学研究費助成事業基盤研究(C)

目黒誠, 水口徹, 川本雅樹, 山口洋志, 石井雅之

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Grant amount：\4810000 （ Direct Cost: \3700000 、 Indirect Cost：\1110000 ）

我々がこれまでに報告してきた、FloTrac/Vigileoシステムを用いた肝切除術中モニタリングにより算出された肝切除後肝不全を予防しうる値である、上大静脈内酸素飽和度（ScvO2)における手術開始時の基準値からのScvO2の低下度（ΔScvO2)が10.2%を超えないように、また、Stroke volume variation (SVV)の術中の平均値（mean SVV)が13.6%を超えないように術中管理の目標として管理することによって術後のアウトカムが変わってくるかどうかを検証することを目的とした（Meguro et al. Surgery 2013でこれらのカットオフ値を報告済み)。肝切除術前に院内IRBにより認可していただき、患者さんに説明し同意していただいた上で肝切除術中にモニタリングを行いつつ、麻酔科医に協力していただきながら、これらの目標値を参考にして術中全身循環管理を行ってきた。具体的には、ΔScvO2値が10.2%を超えるようなときに昇圧剤投与、輸血、補液強化などの管理を行っていただいたところ、以前にSurgery 2013で報告した術中モニタリング値による術中介入を行わなかったときと比べて有意な術後総ビリルビン値の改善が認められた。
また、副次的研究として、SVV値のデータを解析したところ、肝離断中のSVV平均値が13%以上群と13%未満群で比較すると、有意に13%以上群で出血量が少ない結果であった。さらに、術中出血量と術後総ビリルビン最高値との間に正の相関関係が認められた。一般的には肝離断中に中心静脈圧(CVP)を1-3cmH2O未満に管理していただくことで肝静脈からのバックフローによる出血を抑制することができるが、このSVV値をみることでCVPよりもより正確な肝静脈圧のコントロールをすることができ、肝離断中の出血を抑制できる可能性が示唆された重要かつ興味深い結果であった。

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Translational research of the regenerative treatment of using human hepatic stem cells which were frozen by super-freezing program

Grant number：26461921 2014.4 - 2017.3

Japan Society for the Promotion of Science Grants-in-Aid for Scientific Research Grant-in-Aid for Scientific Research (C)

MIZUGUCHI TORU

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Grant amount：\4810000 （ Direct Cost: \3700000 、 Indirect Cost：\1110000 ）

We aimed at establishing the cell harvest method for human hepatocyte with safety and technical issues. We reported an effective method for donor cell harvests with video presentation. We also elucidate clinical values of lactate levels during the cell harvesting. We developed a standard for evaluating postoperative complications. We investigate a cell harvest method regarding anatomical location of the donor cells. BCAA plays an important role to maintain nutritional balance. We also aimed at establishing a banking hepatic stem cells and investigate cell preparation and cell nature. In the research period, we success to separate and culture hepatic stem cells. We tried to protect the method by a patent. Finally, we found an antigen to identify hepatic stem cells and select specific cells for regenerative therapy.

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Research for the establishment of human hepatocytic progenitor cells

Grant number：26670584 2014.4 - 2016.3

Japan Society for the Promotion of Science Grants-in-Aid for Scientific Research Grant-in-Aid for Challenging Exploratory Research

Mitaka Toshihiro, TANIMIZU Naoki, ICHINOHE Norihisa, MIZUGUCHI Toru, HIRATA Koichi

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Grant amount：\3770000 （ Direct Cost: \2900000 、 Indirect Cost：\870000 ）

We performed the experiments to establish hepatocytic progenitor cell lines that can be subcultured. CD44-positive small hepatocytes (CD44-SHs) sorted from SH colonies were cultured in serum-free medium on Matrigel-coated dishes. CD44-SHs could be subcultured at least 4 times and maintain the growth ability for more than 4 months. The cells showed expression of hepatocyte-specific genes and proteins such as albumin and HNF4α in a whole period. CD44-SHs morphologically and functionally demonstrated typical characteristics as hepatocytes. When the cells were transplanted into NOG mouse livers, they could be engrafted and differentiate into hepatocytes. On the other hand, mouse SHs derived from a healthy adult mouse could be lined, which possessed hepatocytic characteristics. Although we succeeded in performing one passage of human SHs, we have not yet succeeded the sequential passages of human SHs. We try to establish human SH lines for clinical application in near future.

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Fundamental Researches for the Application of Human Small Hepatocytes in Clinical Treatment

Grant number：25293289 2013.4 - 2016.3

Japan Society for the Promotion of Science Grants-in-Aid for Scientific Research Grant-in-Aid for Scientific Research (B)

HIRATA Koichi, MITAKA Toshihiro, MIZUGUCHI Toru, TANIGUCHI Naoki, ISHII Masayuki, HONMOU Osamu, MEGURO Makoto, KAWAMOTO Masaki, TATSUMI Hiroomi, ZENBUTSU Hitoshi

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Grant amount：\18070000 （ Direct Cost: \13900000 、 Indirect Cost：\4170000 ）

The researches for the clinical application of human small hepatocyte stem cells (hu-SHSC) for cell transplantation in liver resulted as follows. (1) The hu-SHSC isolation were stable, using the step-wise collagenase perfusion method and the Percoll○R gradient centrifugation method. To identify the specificity of hu-SHSC, histochemical examinations and molecular analysis were reffered. The cytological influence under several kinds of preservation intervals in freezed condition were analysed. Finally, it has been proven that the purification and preservation of hu-SHSC were steadied. (2) The possibility of artificial control on proliferation, differentiation and promotion in hepatic regeneration were satisfied. (3) The transplantation of hu-SHSC in rodent liver was succeeded in proliferation and differentiation. (4)No characteristics concerned to tumorigenicity of SHSC has been examined, but now is ongoing.
SHSC may be a candidate as the donor cell in injured liver.

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Establishment of cell transplantation therapy for hepatic failure by hepatic stem/progenitor cells and/or hepatic organoids

Grant number：24390304 2012.4 - 2015.3

Japan Society for the Promotion of Science Grants-in-Aid for Scientific Research Grant-in-Aid for Scientific Research (B)

MITAKA Toshihiro, TANIMIZU Naoki, ICHINOHE Norihisa, MIZUGUCHI Toru, HIRATA Koichi, SUDO Ryo, KIKKAWA Yamato

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Grant amount：\18330000 （ Direct Cost: \14100000 、 Indirect Cost：\4230000 ）

We showed that a small part of Thy1-positive cells isolated from galactosamine-treated rat livers were hepatic stem/progenitors and could differentiate into hepatocytes by HGF/FGF via CD44-positive ones. However, it was hard for the progenitors to fully differentiate into mature hepatocytes. Transplantation of the Thy1-positive cells or rat bone marrow-derived mesenchymal cells stimulated the growth of resident hepatocytic progenitors in recipient rat livers by IL17B and IL25 that were secreted by sinusoidal endothelial and Kupffer cells, respectively. Laminin alpha 1 chains are necessary to form bile ducts in fetal mouse livers and expression of laminin alpha 5 chains is critical to differentiate into mature cholangiocytes. Plasticity of cholangiocytes to hepatocytes was rapidly lost after birth and Grhl2 expression is crucial to maturation of the cells.

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Developing a novel vaccine therapy targeting cancer stem cells

Grant number：24659592 2012.4 - 2015.3

Japan Society for the Promotion of Science Grants-in-Aid for Scientific Research Grant-in-Aid for Challenging Exploratory Research

HIRATA Koichi, SATO Noriyuki, TORIGOE Toshihiko, TAMURA Yasuaki, HIROHASHI Yoshihiko, MIZUGUCHI Toru, KIMURA Yasutoshi, KUTOMI Goro, OGAWA Tadashi, KOUNO Tsuyoshi

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Grant amount：\3900000 （ Direct Cost: \3000000 、 Indirect Cost：\900000 ）

Pancreatic cancer is known as high mortality disease compared with other cancers due to higher drug resistance and invasive and metastatic potentials. We started to research for developing new treatments that kill pancreatic CSCs selectively by immunological approaches such as cancer vaccines. In past we reported that we identified a CSC specific gene OR7C1 from colorectal cancers, so we thought OR7C1 may be a CSC specific gene in pancreatic cancer, too.
At first, we isolated pancreatic CSCs by sphere culture method and analyze expression levels. Sphere culture cell showed predominantly higher expression of OR7C1 and this suggested that OR7C1 may be a good target for CSC specific therapy. Next, we isolated OR7C1 high expression (OR7C1high) cells by flowcytometry and try to analyze about stemness. But analyses did not work well because we could not expand OR7C1high cells due to cell death and finally we could not identify CSC specific peptides in 3 years.

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A clinical and basic research for developing human small hepatocyte bank using super-cooling program and generating mass hybrid mouse.

Grant number：23591993 2011 - 2013

Japan Society for the Promotion of Science Grants-in-Aid for Scientific Research Grant-in-Aid for Scientific Research (C)

MIZUGUCHI TORU, HIRATA Koichi, MITAKA Toshihiro, NAKAMURA Yukio, KAWAMOTO Masaki, MEGURO Makoto

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Grant amount：\4940000 （ Direct Cost: \3800000 、 Indirect Cost：\1140000 ）

We investigated that basic research for applying clinical liver regenerative therapy and clinical research for securing donor cell procurement. In the basic research, we developed a rat model of liver regenerative therapy by hepatocyte transplantation. In this model, we revealed a cell physiology of the transplanted cells which generated bile duct linage cells. In addition, we succeded to increase survival rate in NASH liver cirrhotic model. In the clinical research, we reported a benefit and default of donor cell procurement. We also revealed that a clinical value of BTR, ATIII, and GSA. We classified various liver functional indicators using clustering analysis. Furthermore, in technical reports, we developed a surgical devise for conducting safety right liver hepatectomy (J Am Col Surg : in press).

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Clinical and Basic Researches of Hepatic Stem Cells onLiver Regeneration as Defense Mechanism.

Grant number：22390259 2010 - 2012

Japan Society for the Promotion of Science Grants-in-Aid for Scientific Research Grant-in-Aid for Scientific Research (B)

HIRATA Koichi, MITAKA Toshihiro, MIZUGUCHI Toru, NAKAMURA Yukio, MEGURO Makoto, KAWAMOTO Masaki, IMAMURA Masafumi, YAMAGUCHI Hiroshi, YAMA Naoya, TATSUMI Hiroomi, OTA Shigenori, KOJIMA Takashi, SAWADA Norimasa

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Grant amount：\19240000 （ Direct Cost: \14800000 、 Indirect Cost：\4440000 ）

We have achieved the results by the clinical and basic studies.【Study 1】We developed a rat model of acute liver failure after 2/3 partial hepatectomy (PH) for non-alcoholic steatohepatitis (NASH)-related cirrhosis. The mechanism by which HT improved the survival of the model rats was examined in short- and long-term investigations. Overall survival was significantly longer in the HT group than the non-HT group (7-day survival rates: 46.7% and 7.7%, respectively). Preoperative HT might improve the survival of rats with NASH-related cirrhosis after PH by preventing the host hepatocytes from accelerating their growth and falling into apoptosis. 【Study 2】We developed software to calculate the pixels of interest in the area between the hepatic and heart curves (ABC) of 99mTc-galactocyl human serum albumin (GSA) scintigraphy. The area under the receiver operating characteristic curve (AUC) was calculated for evaluation of Child-Pugh score grade B (Child B), pathological chronic hepatitis (CH), and liver cirrhosis (LC). We developed a novel liver functional indicator, the ABC, to count radioactivity in sequence.

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Basic research for the production of human hepatocytes and the transplantation of hepatic tissues

Grant number：21390365 2009 - 2011

Japan Society for the Promotion of Science Grants-in-Aid for Scientific Research Grant-in-Aid for Scientific Research (B)

MITAKA Toshihiro, TANIMIZU Naoki, OOE Hidekazu, ICHINOHE Norihisa, MIZUGUCHI Toru, HIRATA Koichi, KIKKAWA Yamato, TANISHITA Kazuo

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Grant amount：\17420000 （ Direct Cost: \13400000 、 Indirect Cost：\4020000 ）

We aimed to develop the methods of producing a large number of small hepatocytes(SHs), hepatic progenitor cells, and to establish the methods of hepatic organoid formation in vitro. In addition, we examined how cells and tissues could be transplanted into liver. Unlike mature hepatocytes the growth of rat SHs was regulated by Follistatin/Activin system. Although oval cells, hepatic stem cells, differentiated into hepatocytes via SHs, they could not completely mature. The transplanted hepatic stem/progenitor cells could not survive for a long term in the recipient liver and disappeared by cellular senescence. Thus, the role of hepatic stem/progenitor cells in severe liver failure may be to compensate for the lost hepatic functions transiently. To use the model of hepatic sinusoids constituting rat SHs, stellate cells, and endothelial cells, we clarified that quiescent stellate cells might regulate the capillary formation of endothelial cells and maturation of SHs.

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Analysis on factors relating metastasis in human gastric cancer cell line focusing on the metastasis patterns

Grant number：21591709 2009 - 2011

Japan Society for the Promotion of Science Grants-in-Aid for Scientific Research Grant-in-Aid for Scientific Research (C)

KIMURA Yasutoshi, HIRATA Koichi, MIZUGUCHI Toru

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Grant amount：\4160000 （ Direct Cost: \3200000 、 Indirect Cost：\960000 ）

To elucidate the mechanisms of cancer metastasis, we established highly lymphatic, liver metastatic and peritoneal disseminated models in nude mice, and then characterized several factors related to metastasis in these cells. We investigated several biological properties and mRNA levels of differentially-expressed genes involved in cancer metastasis by cDNA macroarray. We also conducted the availability of metastasis inhibition substances and the relation between metastatic potential and angiogenesis factorts. To date, Endothelin expression level in gastric cancer cell line might contribute to the liver metastasis and VEGF-C to the lymphatic metastasis. Osteopontin might also contribute to the liver metastasis in pancreatic cancer cell line.

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Development of hybrit mouse with humanized liver using superfreezing preserved human small hepatocytes.

Grant number：20591615 2008 - 2010

Japan Society for the Promotion of Science Grants-in-Aid for Scientific Research Grant-in-Aid for Scientific Research (C)

MIZUGUCHI Toru, HIRATA Koichi, MITAKA Toshihiro, NAGAYAMA Minoru, MEGURO Makoto, SHIBATA Toshihito, KAJI Shinsuke, KAWAMOTO Masaki, NAKAMURA Yukio

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Grant amount：\4550000 （ Direct Cost: \3500000 、 Indirect Cost：\1050000 ）

It is very important to perform surgical operation to obtain cell donation for cell transplantation therapy. Conventional hepatectomy has been considered to be difficult to decrease high mobidity with mortlity. A saline-linked electiric cautery was very effective to achieve vessel sealing and decrease bleeding. In addition, recovery of postoperative Apo-B in this group was much faster than conventional hepatectomy (Hepatogastroenterology 2008 ; 55 : 2188-2192.). Gene transduction of Pdx-1 could transform small hepatocyte into insulin, glucagon, and somatostatine producing cells. Furthermore, small hepatocytes tend to be trans-differentiated into beta cells and mature hepatocytes tend to be trans-differentiated into alpha cells after transduction of Pdx-1 gene (J Hepatobiliary Pancreat Surg 2008 ; 15 : 403-409.). On the other hand, urinary trypsin inhibitor (UTI) is one of the proteins which the liver could produce by itself exclusively. The liver regeneration has been impaired in UTI deficient animals (Liver Int 2009 ; 29 : 979-987.). The gene expression could be depending on host conditions and human races. So, we compared gene expressions using micro DNA array analysis among Japanese patients and Finn patients (Genes Chromosomes Cancer 2010; 49: 28-39.). We proved all above research results and presented the data in both national and international congresses. We also discuss each other to promote further collaboration in future.

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免疫逃避克服による新規癌ペプチドワクチン療法の確立

Grant number：20659202 2008 - 2009

日本学術振興会科学研究費助成事業挑戦的萌芽研究

平田公一, 佐藤昇志, 水口徹, 鳥越俊彦, 古畑智久, 大村東生, 山口浩司

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Grant amount：\3200000 （ Direct Cost: \3200000 ）

1. 研究計画書の作成と臨床研究審査委員会への提出及び並行的研究
研究計画書については臨床研究審査会の承認を得たが、他診療科でのペプチドワクチン癌療法実施例において、脳出血をともなったとのことで、その内容を吟味した結果、以下の結論となった。当該症例においては、抗凝固療法併用中であり、ペプチド、インターフェロンαが本患者において、危険性を完全に否定することもできず、関連性については不明と考える。以上のことから適応外基準に「抗凝固療法をおこなっている」の一文を追加とすることが妥当との結論に至った。その後、研究継続が承認されたため、症例登録を開始することとした。なお、並行して行っているバルプロ酸非投与プロトコール投与の処方のもと、臨床試験に参加いただいている症例にあっては、基礎的研究としてスクリーニングをし、その推移から臨床効果との比較検討をすることも目的とした。
2. サバイビン2Bペプチドワクチン投与例について
上記の最終臨床報告書が臨床研究審査会の再考に到っていなかったため、バルプロ酸投与を除いた形でサバイビン2BペプチドとIFNの投与を行っている。
これらは今日までの一貫したプロトコールの中で行い、平成21年度の本研究費該当期間については以下の5例に施術した。
(1) 有効性
5症例中2例で画像上SD、腫瘍マーカー不変という結果が見られた。他の3例は画像上PD、2例が腫瘍マーカー増加という結果であった(平滑筋肉腫症例は特異的腫瘍マーカー存在しないため未測定)
(2) 安全性
有害事象は3例に発熱がみられているがいずれもgrade2以下である。他に重篤な有害事象は起こっていない。
(3) 逸脱例
投与日の大幅な変更や臨床試験中止となるような逸脱例はなかった。

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Basic research objected to establish the highly qualified assessment of hepatic reserve function by utilizing new molecular marker localized in liver

Grant number：19390353 2007 - 2009

Japan Society for the Promotion of Science Grants-in-Aid for Scientific Research Grant-in-Aid for Scientific Research (B)

HIRATA Koichi

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Grant amount：\18720000 （ Direct Cost: \14400000 、 Indirect Cost：\4320000 ）

The researches were composed of three kinds of contents as follows : (1) the studies about low localized molucules utilized for the assessments of hepatic function, (2) the regulation on isolation, identification and proliferation of hepatic stem cells recognized to have key roles and (3) the possibility of gene-transfected hepatocyte or heparic stem cell on the treatment for hepatic dysfunction. Our results showed (1) the logical significance of asialoglycoprotein receptor count method and the distribution of adhesion molecules (especially claudins) on hepatic cell function, (2) successful modification of hepatic stem cells in vitro, and (3) the clinical capability by the cell transplantation utilized gene-transfected hepatocytes or fresh hepatic stem cells.

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Analysis of the hepatic transporter expression and the research regarding the control in the large animal hepatectomy model

Grant number：19591515 2007 - 2008

Japan Society for the Promotion of Science Grants-in-Aid for Scientific Research Grant-in-Aid for Scientific Research (C)

NAGAYAMA Minoru, HIRATA Koichi, MIZUGUCHI Toru, KIMURA Yasutoshi, MEGURO Makoto

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Grant amount：\3900000 （ Direct Cost: \3000000 、 Indirect Cost：\900000 ）

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The analysis of the gene cluster and biological function about the gastric cancer cell lines highly metastatic to liver and lymph node metastasis

Grant number：19591550 2007 - 2008

Japan Society for the Promotion of Science Grants-in-Aid for Scientific Research Grant-in-Aid for Scientific Research (C)

YAMAGUCHI Koji, KIMURA Yasutoshi, MIZUGUCHI Toru, HIRATA Koichi, YAMAGUCHI Koji

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Grant amount：\4160000 （ Direct Cost: \3200000 、 Indirect Cost：\960000 ）

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高い有効性を誘導するための新たなる癌ペプチドワクチン療法適応決定因子の確立

Grant number：18659374 2006 - 2007

日本学術振興会科学研究費助成事業萌芽研究

平田公一, 佐藤昇志, 水口徹, 鳥越俊彦, 古畑智久, 山口浩司, 桂巻正, 鶴間哲弘

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Grant amount：\3300000 （ Direct Cost: \3300000 ）

サバイビン2Bペプチドワクチン投与により、ペプチド特異的tetramer陽性CTLの発現頻度上昇およびELISPOT assayでのスポット数増加などのペプチド特異的免疫学的反応を誘導しても、必ずしもすべての症例に臨床学的抗腫瘍反応を認めない場合があることを明らかにした。また、そのような免疫学的反応と臨床学的反応の相違を生じる症例の多くに、癌原発巣におけるMHCクラスI発現の低下を認めたことより、MHCクラスI発現の低下がペプチドワクチンによる臨床学的効果非誘導の一因子となりうるのではないかと考えられた。また、癌原発巣におけるMHCクラスI発現の程度が、癌そのものの悪性度にも深く関与しているのではないかと考え、当院での大腸癌および膵臓癌における手術症例でのMHCクラスI発現の程度と予後および病理学的因子との相関についても検討した。すると、MHCクラスI発現低下群では、非低下群に比較し有意に生存率低下を認めた。また、大腸癌においては脈管侵襲因子とともに、膵臓癌においてはN因子とともにMHCクラスI発現の程度が予後因子であることが判明した。以上より、MHCクラスI発現の程度は重要な悪性度を示す指標と考えられ、かつ、MHCクラスI発現低下症例ではペプチドワクチン療法により抗腫瘍臨床学的効果を得難いことが明らかとなった。このような結果より、今後は、より高い抗腫瘍臨床効果を高率に得るためには、MHCクラスI発現が低下していない低悪性度症例をペプチドワクチン療法の最適な治療適応とすべきと考えられた。
また、本年度は、進行・再発乳癌におけるサバイビン2Bペプチドの免疫学的および臨床学的評価についての研究結果を論文化し、Journal of Translational Medicineにaccept(in press)された。

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Development of novel cocktail solutions for cryo-preserving human small hepatocytes and generation of humanoid mouse liver

Grant number：18591519 2006 - 2007

Japan Society for the Promotion of Science Grants-in-Aid for Scientific Research Grant-in-Aid for Scientific Research (C)

MIZUGUCHI Toru, HIRATA Koichi, KAJI Shinsuke, SHIBATA Toshihito, NAGAYAMA Minoru, MEGURO Makoto

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Grant amount：\3950000 （ Direct Cost: \3500000 、 Indirect Cost：\450000 ）

Hepatocyte transplanation (HT) is an attractive therapeutic modality for liver disease as an alternative for liver organ transplantation. Primary fresh hepatocytes (FHs) are the exclusive cell source that has been used for clinical HT. However, the use of FHs is limited due to a shortage of donor cells. Small hepatocytes (SHs) are hepatic progenitor cells, and can be isolated not only from rodents but also from humans. SHs can proliferate in vitro and express liver functions, although conventional hepatocytes lose them within a short period after culture. SH functions in vivo have never been studied. We therefore investigated HT using SHs to evaluate cell engraftment and function compared to HT using FHs.
The donor cell number in the SH group was smaller than that in the FH group at HT. The cell engraftment in the SH group was smaller in the liver and larger in the spleen than in the FH group. The cell engraftment in the liver increased after HT ; however, that in the spleen decreased after HT in both groups. HT using SHs supported the serum albumin level in the NAR experiment as well as that using FH, and albumin mRNA was detectable in the recipients' tissues at 12 weeks after HT.
In conclusion, HT using SHs showed hepatic repopulation similar to that using FHs. This suggests that both SHs and FHs can repopulate the liver as if they were hepatic stem cells. In addition, HT using SHs supported liver functions such as albumin correction at the same level as that using FHs. These observations strongly support the idea that SHs could be an alternative to primary FHs as a novel cell source for future HT.

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Research for the formation of hepatic organoids by using human hepatic progenitor cells and the model of artificial liver device incorporated with human hepatic organoids

Grant number：17390353 2005 - 2007

Japan Society for the Promotion of Science Grants-in-Aid for Scientific Research Grant-in-Aid for Scientific Research (B)

MITAKA Toshihiro, KIKKAWA Yamato, KON Junko, ICHINOHE Norihisa, MIZUGUCHI Toni, HIRATA Koichi

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Grant amount：\16900000 （ Direct Cost: \15400000 、 Indirect Cost：\1500000 ）

We have reported that CD44 is specifically expressed in rat small hepatocytes and that CD44^+ hepatocytes transiently appear in injured rat livers. Using a specific antibody, we sorted CD44^+ cells from galactosamine-treated rat livers and cultured them. The phenotypes and gene expression of the cells were similar to those of cultured SHs and the ^+ cells could differentiate into hepatocytes (J Hepatol, 2006). In addition, some Thy1^+ cells that appeared in the galactosamine-treated livers could differentiate into + SHs and mature into hepatocytes. When the Thyl+ and CD44^+ cells were transplanted into livers treated with retrorsine/PH, they could survive and proliferate to form hepatic foci in the recipient livers. Furthermore, when cultured SHs were transplanted into congenic rat livers treated with radiation/PH, the cells migrated into hepatic trabecules and the liver was partially repopulated by the donor cells (Liver Transplant, 2006). Rat SHs cultured in hyaluronic acid (HA ; ligand for CD44)-coated dishes and serum-free medium could selectively proliferate with hepatic functions (Nature Protocols, 2007) and this method could be applied for the isolation of human SHs from normal liver tissues, which were surgically resected from patients with informed consent. The number of human SHs increased about 100-fold within 3 weeks and the cells showed hepatic characteristics such as albumin secretion (Cell Transplant, 2008). Furthermore, we found that the proliferation of rat SHs was enhanced by follistatin produced by SHs to inhibit the action of activin A, which is secreted by mature hepatocytes. On the other hand, we succeeded in reconstructing functional hepatic tissues by stacking up two-dimensional tissues composed of rat SHs (FASEB J, 2006). In addition, we could culture normal rat biliary epithelial cells for a long term and reconstruct functional bile ductules between collagen gels (Am J Pathol, 2008).

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Development of new therapy for prevention of fibrosis in liver cirrhosis or chronic pancreatitis.

Grant number：17591420 2005 - 2006

Japan Society for the Promotion of Science Grants-in-Aid for Scientific Research Grant-in-Aid for Scientific Research (C)

KATSURAMAKI Tadasi, HIRATA Koichi, MIZUGUCHI Touri, KIMURA Yasutoshi, NAGAYAMA Minoru

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Grant amount：\3500000 （ Direct Cost: \3500000 ）

Inducible nitric oxide synthase (iNOS) activity was significantly elevated in viral hepatitis, alcoholic cirrhosis, and cholestasis. however, there are few reports on the relationship between iNOS and cirrhosis. Here, we investigated the effects of a new iNOS inhibitor which has been developed for oral administration in an experimental rat liver cirrhosis model. A cirrhotic rat model was developed by long-term administration of thioacetamide (TAA) injections. FR260330, is a new, rationally designed, selective iNOS inhibitor that can be administered orally. After 12 weeks of treatment with FR260330, the rats showed inhibition of progressions of cirrhosis, ascites, and splenomegaly as well as a significant reduction in the proportions of connective tissue in the liver. The expression of nitrotyrosine, which indicates the existence of peroxynitrite and nuclear factor- kappa B (NFkB) activation, was remarkably decreased in the FR260330 treatment group. In addition, imnunohistochemical and western blot analyses showed that the expression of transforming growth factor beta-1 (TGFb1) was remarkably decreased in this group. The present study demonstrates that FR260330 reduces liver fibrosis by the inhibition of TGFb1 and retards the development of cirrhosis. This oral iNOS inhibitor will be a new strategy for the treatment of cirrhosis

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Research of the mechanism of non-obstructive cholestasis in severe infection and of the treatment for hepatic insufficiency

Grant number：15390403 2003 - 2005

Japan Society for the Promotion of Science Grants-in-Aid for Scientific Research Grant-in-Aid for Scientific Research (B)

HIRATA Koichi, MITAKA Toshihiro, KATSURAMAKI Tadashi, MIZUGUCHI Tohru, TSURUMA Tetsuhiro, NOBUOKA Takayuki

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Grant amount：\14100000 （ Direct Cost: \14100000 ）

(1)It has been suggested that the mostly irregular contractions of bile canalicular net work constituted among the hepatoid structure by cultured small hepatocytes were. This movement was presented as calculated number by the specific-soft utilization of analysis for the changes of bile canalicular contraction in vitro. Moreover, some circumstances and their influences on several transporters on membrance have been studied. Interesting results have already been published during this research schedule.
(2)The completion of hepatoid tissue in vitro by cultured small hepatocyte purified from Sprague-Dawley rat (male, 6-10 week age) liver had successfully been performed. And then the distribution of transportaters localized on membrane of colonied small hepatocytes which constituted hepatoid tissue was studied by the hemi-quantitative RT-PCR and the immunofluorescence method. Preserved small hepatocytes in refregerater had been tried to culture repeatedly and the successful results showed that the colonied hepatocytes were slightly enlarged during 4 weeks after the start of culture and the hepatoid tissue with trabecular patterns of bile canallculus formed among cultured hepatocytes was organized. On the analysis of RT-PCR, the up-regulations of Oatp (organic anion transporting polypeptide) family, Ntcp (Na taurocholate cotransporting polypeptide), Mrp2 (multiple resistance associated protein 2) and Besp (bile salt export pump), which of all are the up-take transporters of bilirubin and bile acids or the excretion-type transporters of them, were definitely observed. Under the TNF-α addition in culture, the down-regulation or decreased of proteins of Oatp2 and CAR (constitutive androstane receptor), was induced.
(3) Human small hepatocyte was isolated from the resected liver after hepatectomy in our department. Those procedures were performed on the material without HBV and HCV infection by serum-analysis. Successful results were experienced in all cases but wide differences in results were ascertained. Further studied would be continued.

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活性型小型肝細胞と骨髄細胞とによる全肝再生置換細胞移植方法の確立

Grant number：15790696 2003 - 2004

日本学術振興会科学研究費助成事業若手研究(B)

水口徹

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Grant amount：\3500000 （ Direct Cost: \3500000 ）

これまでの肝細胞移植では新鮮肝細胞が使用されてきた。小型肝細胞は培養条件下においても増殖可能であり、ヒトからも分離可能であるため将来の肝細胞移植の移植細胞源として有力な候補である。今回、小型肝細胞と新鮮肝細胞を比較し、放射線照射による肝再生置換モデルを使用し、移植効率やアルブミンで評価した蛋白合成機能に関して検討した。50Gyの肝臓放射線照射により新鮮肝細胞を使用したモデルでは部分的な肝再生置換に成功した。また、2/6匹においては完全に近い肝再生置換を観察した。一方、培養小型肝細胞を使用したモデルにおいては、新鮮肝細胞に比べ肝臓での移植細胞は低率であったが、経過中は漸増傾向にあった。脾臓においては、新鮮肝細胞群で早期に移植細胞が漸減するのにくらべ培養小型肝細胞においては移植細胞がとどまる傾向が見られた。とくに、培養小型肝細胞群の移植後3ヶ月での脾臓においては類肝組織や胆管構造の再構築が見られた。そこで、小型肝細胞による肝細胞移植を肝機能補助の観点から検討した。無アルブミンラットを用いた実験を行った。これには、免疫抑制剤を使用し、よりヒト臨床に近いモデルで行った。血清アルブミン値では両群間に統計学的有意差を認めず、12週では2.5mg/dlと改善した。肝臓におけるアルブミンの発現にはmRNAレベルおよび蛋白レベルで両群間に有意差を認めなかったが、脾臓においては小型肝細胞群において有意に発現を認めた。肝臓ではアルブミン陽性細胞を両群において肝細胞に認めたが、新鮮肝細胞群では散在性に見られるのに対して培養小型肝細胞群においては集団塊を形成しコロニー様の構造を呈していた。本実験では移植細胞数が培養小型肝細胞群において1/20と少数であったことを考慮すると培養小型肝細胞は肝再生置換効率では新鮮肝細胞とほぼ同等と考えられた。免疫抑制下においては移植細胞の生着が抑制される傾向にあったが、培養小型肝細胞は新鮮肝細胞と同等にアルブミンを補正した。とくに培養小型肝細胞では脾臓において新鮮肝細胞より長期に生着し、類肝組織を形成することから肝臓同様の細胞機能を発現していることが示唆された。これは、移植細胞が肝臓で再生置換される間に十分な機能補助を脾臓での移植肝細胞が補填できる可能性を示唆している。これらの結果より、培養小型肝細胞移植は肝再生置換効率や肝機能補助の点からも新鮮肝細胞移植と同等と考えられた。

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Identification of specific surface proteins in small hepatocytes and reconstruction of hepatic organoids ex vivo.

Grant number：14370393 2002 - 2004

Japan Society for the Promotion of Science Grants-in-Aid for Scientific Research Grant-in-Aid for Scientific Research (B)

MITAKA Toshihiro, TAKEDA Hiroshi, KIKKAWA Yamato, HIRATA Koichi, KATSUMMALA Tadashi, MIZUGUCHI Toru

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Grant amount：\13900000 （ Direct Cost: \13900000 ）

We found three genes, CD44, BRI3, and D6.1A, with much higher expression in small hepatocytes (SHs)than in mature hepatocytes (MHs)and possessing transmembrane domain. Using specific antibody to CD44, BRI3, and D6.1A, we examined the localization of SHs in a rat liver. Although none of expressions of the proteins were observed in hepatic lobules of a normal liver, the hepatocytes reacting with the antibodies existed in the periportal lesion of severely injured liver treated with galactosamine. Using the antibody with magnetic beads (MACS), CD44+ cells were sorted from the galactosamine-treated livers and then cultured. The CD44+ cells could proliferate and form colonies, which are morphologically similar to SHs. Although hepatic marker genes were expressed in both sorted and cultured CD44+ cells, neither bile duct cell nor oval cell marker genes were detected by PCR. When cultured SHs were transplanted into congenic rat livers in combination with radiation and partial portal ligation, SHs were inserted into hepatic trabecules and proliferated.
To reconstruct hepatic organoids, we tried three different methods. (1)When SHs and NPCs were plated on collagen sponge, SHs could proliferate and expand to form a hepatic organoid in the sponge. The structure includes MHs with bile canaliculi, bile ducts, and capillary-like structures. Furthermore, we also observed that isolated human hepatic cells could form hepatic organoid in the sponge. (2)After SHs were cultured on two multiporous membranes until they formed large colonies, one membrane were stacked on the other membrane as cells faced each other. The stacked cells could differentiate into MHs with forming bile canalicular networks. (3)When both SH colonies and the connective tissues of the remnant after the hepatocyte isolation were cultured in the microgravity rotating culture system, a relatively large size of hepatic organoids was formed with a few weeks.

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Basic research of the treatment for hepatic failure by hepatocyte transplantation

Grant number：13557107 2001 - 2003

Japan Society for the Promotion of Science Grants-in-Aid for Scientific Research Grant-in-Aid for Scientific Research (B)

HIRATA Koichi, MITAKA Toshihiro, KATSURAMAKI Tadashi, MIZUGUCHI Toru, KIMURA Yasutoshi, TSURUMA Tetsuhiro, NOBUOKA Takayuki

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Grant amount：\13800000 （ Direct Cost: \13800000 ）

[Background] It is envisaged that hepatocyte transplantation and extracorporeal liver support systems may be a future alternative therapy to orthotopic liver transplantation. Small hepatocytes known as liver hepatocyte stem cells would be considered to be more adequate in hepatoyte transplantation. In addition, if a kind of specific function by a gene transfection to small hepatocytes was inducted, some benefits would provide for the patients with hepatic failure.
[Object] At first, small hepatocytes were determined as the objective cell source in hepatocyte transplantation. Whether alternative changes of contructed hepatocytes from recipient hepatocytes to small hepatocytes might occur or not has been studied. Therefore, PDX 1 gene, an insulin-producing gene, was tranfected to small hepatocytes by adenovial infection and those stem cells were analysed about the functional maintenance in vitro and in vivo. And the possibility of hepatosyte transplantation by those cells has been tried.
[Experimental Classification] This research is composed of three kinds of experiments as shown as followings.
(1) Establishment of the transfection method of insulin-production gene. The transfection of PDX-1 gene, as an insulin-producing gene to adult hepatocytes and to small hepatocytes had been studied by the infection of adenoviral vectors. The expression of transfere genes, the production of pancreatic endocrine hormones and the characteristics of the hepatocytes were immurohis topathologically made sure in the transfected cells.
(2) Expression and production of insulin in the transfected cells. Immunohistologic determination of the transfected cells, analysis of m-RNA specific to the proteins, maintenance of function in the transfected cells were studied.
(3) Hepatocyte transplantation in vivo. Small hepatocyte or adult hepatocytes with or without transfection of the gene were transplanted into liver via the injection into spleen.
[Results] All of above research plans have been performed during 2001 to 2004, as shown in followings.
(1) Expression of several transfere factors were determined in the infected cells after the transfection of PDX-1. The quantitations of insulin, glucagon, somatostatin and pancreatic polypeptide in the cultured solution were succeeded. But it was very difficult to get the stable transfection and to repeat this experiment successfully.
(2) The transfection rates were extremely low but was observed higher in the adult hepatocytes than in small hepatocytes. The limitation of the maintenance of the function gained by transfection was strongly impressed on this research.
(3) Highly succeeded repopulation in the recipient liver was observed in the experiment with non gene transfected small hepatocytes and the proliferation of small hepatocyte in injected was also confident.
[Conclusion] This pilot research suggest that small hepatocytes transplantations would invite an entrance of the actuarial utilization of clinics.

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Study of analysis of bile stasis using the extracorporeal hepatic tissue model and of the effect of cell transplantation on hepatic failure

Grant number：12470265 2000 - 2002

Japan Society for the Promotion of Science Grants-in-Aid for Scientific Research Grant-in-Aid for Scientific Research (B)

HIRATA Koichi, FURUHATA Tomohisa, KATSURAMAKI Tadashi, MITAKA Toshihiro, MIZUGUCHI Toru, HONMA Toshio

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Grant amount：\13600000 （ Direct Cost: \13600000 ）

This research program was composed of three components, namely the first is"the establishment extracorporeal hepatic tissue structure", the second is"the study of bile stasis under in vitro condition" and the third is "the treatment of hepatic failure by cell transplantation". The first one is most important research extending to the regenerative medicine and to the tartificial liver. The culture of small hepatocyte invited the organoid structure resembling with liver, tissue. Moreover, small hepatocytes maintain growth ability and hepatic differentiated functions even after long-term cryopreservation. This result means that the establishment of isolation method for mouse and human hepatocytes will be important, and the application of the method shown in this study may be useful for the establishment of a hepatocyte bank and development of an artificial liver. The second research was performed by the number of bile canalicular contractions in the couplets treated with cytokines. The rapid movement of a droplet from bilecanaliculus was observed at the intercellular space of the hepatocyte couplet treated with TNF-α. And TNF-αand IL-6 reduce bile canaliculus contractions. Moreover, the similar result was observed in the movement of bile canaliculus formed in hepatic organoid structure reconstructed by rat small hepatocytes and nonparenchymal cells.
The utilization of those hepatic cells referred to cell transplantation into a liver. The successful proliferation of the injected hepatocyte observed in some cases, but reproducible results in experiments have not been established. Further efforts would be required for the establishment of hepatocytic stem cell transplantation in liver tissue.
In summary, we demonstrated that, the culture of small hepatocyte provides a hepatoid structure, improves hepatocyte differentiation and maintains a tissue-specific plans typical characteristics. This might have a significant therapeutic impact on the care of the patients with liver failure.

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肝幹細胞移植による肝再生置換療法の確立

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Grant type：Competitive

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