研究者詳細 - 水口　徹

論文 - 水口　徹

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ロボット支援肝切除の導入と初期成績

村上武志, 永山稔, 今村将史, 加藤透, 久木田和晴, 水口徹, 木村康利, 竹政伊知朗

日本臨床外科学会雑誌 ( 日本臨床外科学会 ) 85 ( 2 ) 295 - 295 2024年02月

ePROによる手術部位感染症が肝胆膵外科手術後の総医療費へ与える評価

水口徹, 石貫智裕, 加藤透, 合田恵理香, 進士誠一, 吉田寛, 渡邉学, 横尾英樹, 柴田英貴, 青木武士, 問山裕二, 西森英史, 秦史壯

日本外科感染症学会雑誌 ( (一社)日本外科感染症学会 ) 20 ( 3 ) 474 - 474 2023年11月

オンラインPRO情報システムによるがん手術患者の術創部感染症の危険因子と予後の検証

石貫智裕, 久冨五郎, 島宏彰, 和田朝香, 青木武士, 吉田寛, 渡邉学, 長田拓哉, 横尾英樹, 問山裕二, 大西浩文, 林宏至, 森脇健介, 大柳俊夫, 水口徹

日本癌治療学会学術集会抄録集 ( (一社)日本癌治療学会 ) 61回 P61 - 5 2023年10月

【周術期感染管理マニュアル】肝臓手術における周術期感染管理

永山稔, 石貫智裕, 水口徹

日本外科感染症学会雑誌 ( (一社)日本外科感染症学会 ) 20 ( 2 ) 113 - 116 2023年09月

Synergistic antitumor effect of histone deacetylase class IIa inhibitor with lenvatinib in hepatocellular carcinoma.

Ryo Ito, Koji Miyanishi, Tomohiro Kubo, Kota Hamaguchi, Takahiro Osuga, Shingo Tanaka, Hiroyuki Ohnuma, Kazuyuki Murase, Kohichi Takada, Minoru Nagayama, Yasutoshi Kimura, Toru Mizuguchi, Ichiro Takemasa, Junji Kato

Hepatology international 17 ( 3 ) 735 - 744 2023年06月 [国際誌]

BACKGROUND: Histone deacetylase (HDAC) class I and IIa are highly expressed in hepatocellular carcinoma (HCC) and associated with decreased survival. However, clinically used pan and class I inhibitors have serious adverse events. In this study, we assessed the antitumor effects and tolerability of class IIa HDAC inhibitor (HDACI) with lenvatinib, which is a standard therapy for HCC. METHODS AND RESULT: Combination therapy with class IIa HDACI and lenvatinib exerted synergistic antitumor effect in human HCC cell lines. In mouse models, this therapy showed significant antitumor effects, and few adverse events occurred. In immunoblotting, the expression of fibroblast growth factor receptor 4 (FGFR4) and fibroblast growth factor 19 (FGF19) was high in cell lines that showed a high antitumor effect. In addition, class IIa HDACI administration decreased the expression of FGFR4. In the small interfering RNA (siRNA) analysis, knockdown of HDAC9, which is an isoform of HDAC class IIa, reduced the expression of FGFR4 and induced apoptosis. Immunohistochemistry of human clinical specimens showed a positivity rate of 32% for FGFR4 and 84% for HDAC9 in HCC, and all FGFR4-positive patients were HDAC9 positive. CONCLUSION: Class IIa HDACI and lenvatinib combination therapy induces apoptosis by downregulating FGFR4 and blocking the FGFR signaling in FGFR4-positive HCC cell lines and has demonstrated synergistic antitumor effects and safety. This combination therapy overcomes the problems of conventional therapies and will be beneficial for FGFR4-positive HCC patients.

DOI PubMed

肝がん患者のSSI発生に関連する要因の検討

石貫智裕, 合田恵理香, 巽博臣, 加藤透, 原田敬介, 升田好樹, 大西浩文, 秦史壯, 大柳俊夫, 水口徹

日本外科系連合学会誌 ( 日本外科系連合学会 ) 48 ( 3 ) 409 - 409 2023年05月

肝がん患者のSSI発生に関連する要因の検討

石貫智裕, 合田恵理香, 巽博臣, 加藤透, 原田敬介, 升田好樹, 大西浩文, 秦史壯, 大柳俊夫, 水口徹

日本外科系連合学会誌 ( 日本外科系連合学会 ) 48 ( 3 ) 409 - 409 2023年05月

Positional advantages of supine MRI for diagnosis prior to breast‑conserving surgery.

Goro Kutomi, Hiroaki Shima, Daisuke Kyuno, Fukino Satomi, Asaka Wada, Yoko Kuga, Minoru Okazaki, Akira Okazaki, Hideji Masuoka, Toshihiko Mikami, Yuichi Yuyama, Takashi Matsuno, Tosei Ohmura, Hidekazu Kameshima, Toru Mizuguchi, Ichiro Takemasa

Molecular and clinical oncology 18 ( 5 ) 44 - 44 2023年05月 [国際誌]

The present study aimed to evaluate the rate of positive surgical margins for magnetic resonance imaging (MRI) performed in the supine position prior to breast-conserving surgery (BCS). The rate of positive surgical margins and the clinicopathological factors were examined in consecutive patients with BCS who underwent preoperative MRI performed in the supine position at Sapporo Medical University Hospital (Sapporo, Japan) and related hospitals and clinics between January 2012 and December 2013. Of 1,175 eligible patients, 1,150 were included after excluding 25 patients with either bilateral breast cancer or stage IV disease. Positive margin was defined as no cancer seen on the resected margin. The primary endpoint was the rate of positive surgical margins when preoperative MRI was performed in the supine position and the secondary endpoint was identification of the factors that predict positive margins. Of the 1,150 female patients (median age, 55 years; range, 29-97 years) who underwent BCS for breast cancer following MRI performed in the supine position, 215 (18.8%) had positive margins, which is similar to the rate with MRI in the prone position, and 930 (81.2%) had negative margins. The rate of positive surgical margins in patients of the human epidermal growth factor receptor 2 (HER2) type was significantly higher than that in the non-HER2 type group (6.5 and 2.9%; χ2 P=0.0103). There was no increase in the rate of positive margins in breast cancers with a diameter of >T2. The rate of positive surgical margins following MRI performed in the supine position was 18.8%. Supine MRI appears to be suitable for informing on the extent of resection of breast cancer.

DOI PubMed

一次縫合創に対するNPWTの最適な適応とは SSI予防ガイドラインの次期改定に必要な予防的NPWTに関する有効性の再考

水口徹, 石貫智裕, 張苓, 巽博臣, 久野芳佳, 原田敬介, 大西浩文, 加藤透, 沖田憲司, 川本雅樹, 目黒誠, 秦史壯, 大柳俊夫

日本外科感染症学会雑誌 ( (一社)日本外科感染症学会 ) 19 ( 1 ) 185 - 185 2022年10月

肝臓

水口徹, 石貫智裕, 張苓, 巽博臣, 久野芳佳, 原田敬介, 大西浩文, 加藤透, 沖田憲司, 川本雅樹, 永山稔, 竹政伊知朗, 大柳俊夫

日本外科感染症学会雑誌 ( (一社)日本外科感染症学会 ) 19 ( 1 ) 230 - 230 2022年10月

肝胆膵外科における周術期感染対策肝切除後の腹腔内合併症に対する治療方法の検討

永山稔, 木村康利, 加藤透, 村上武志, 久木田和晴, 今村将史, 水口徹, 竹政伊知朗

日本外科感染症学会雑誌 ( (一社)日本外科感染症学会 ) 19 ( 1 ) 153 - 153 2022年10月

当科における肝硬変合併肝細胞癌に対する腹腔鏡下肝切除術と周術期成績

永山稔, 加藤透, 村上武志, 久木田和晴, 今村将史, 水口徹, 伊東竜哉, 信岡隆幸, 木村康利, 竹政伊知朗

日本消化器外科学会雑誌 ( (一社)日本消化器外科学会 ) 55 ( Suppl.2 ) 328 - 328 2022年10月

当科における腹腔鏡下肝葉切除の手技と成績

加藤透, 永山稔, 木村康利, 今村将史, 久木田和晴, 村上武志, 水口徹, 竹政伊知朗

日本臨床外科学会雑誌 ( 日本臨床外科学会 ) 83 ( 増刊 ) S458 - S458 2022年10月

一次縫合創に対するNPWTの最適な適応とは SSI予防ガイドラインの次期改定に必要な予防的NPWTに関する有効性の再考

水口徹, 石貫智裕, 張苓, 巽博臣, 久野芳佳, 原田敬介, 大西浩文, 加藤透, 沖田憲司, 川本雅樹, 目黒誠, 秦史壯, 大柳俊夫

日本外科感染症学会雑誌 ( (一社)日本外科感染症学会 ) 19 ( 1 ) 185 - 185 2022年10月

肝臓

水口徹, 石貫智裕, 張苓, 巽博臣, 久野芳佳, 原田敬介, 大西浩文, 加藤透, 沖田憲司, 川本雅樹, 永山稔, 竹政伊知朗, 大柳俊夫

日本外科感染症学会雑誌 ( (一社)日本外科感染症学会 ) 19 ( 1 ) 230 - 230 2022年10月

【ここまで進んだERAS】肝外科

石貫智裕, 太田盛道, 小野崎由香, 加藤透, 川本雅樹, 目黒誠, 永山稔, 竹政伊知朗, 大柳俊夫, 水口徹

消化器外科 ( (株)へるす出版 ) 45 ( 9 ) 1003 - 1010 2022年09月

Current standard values of health utility scores for evaluating cost-effectiveness in liver disease: A meta-analysis

Tomohiro Ishinuki, Shigenori Ota, Kohei Harada, Masaki Kawamoto, Makoto Meguro, Goro Kutomi, Hiroomi Tatsumi, Keisuke Harada, Koji Miyanishi, Toru Kato, Toshio Ohyanagi, Thomas T Hui, Toru Mizuguchi

World Journal of Gastroenterology ( Baishideng Publishing Group Inc. ) 28 ( 31 ) 4442 - 4455 2022年08月

DOI

Association between Hepatic Oxidative Stress Related Factors and Activation of Wnt/β-Catenin Signaling in NAFLD-Induced Hepatocellular Carcinoma.

Kota Hamaguchi, Koji Miyanishi, Takahiro Osuga, Shingo Tanaka, Ryo Ito, Hiroki Sakamoto, Tomohiro Kubo, Hiroyuki Ohnuma, Kazuyuki Murase, Kohichi Takada, Minoru Nagayama, Yasutoshi Kimura, Toru Mizuguchi, Ichiro Takemasa, Junji Kato

Cancers 14 ( 9 ) 2022年04月 [国際誌]

We investigated the association between iron overload, oxidative stress (8-oxo-7,8-dihydroguanine: 8-oxo-dG scores), Wnt/β-catenin pathway activation (expression of glutamine synthetase: GS), and tumor hyperintensity in the Gd-EOB-DTPA-enhanced MRI hepatobiliary phase (relative enhancement ratio: RER). This was a retrospective analysis of 94 hepatocellular carcinoma (HCC) patients who underwent surgical resection. In HBV-, HCV-, and alcohol-associated HCC, serum ferritin levels in the high and low RER groups were equivalent. In contrast, ferritin levels were elevated in the 'high RER' group of patients with nonalcoholic fatty liver disease (NAFLD)-HCC. As predictors of GS positivity, high RER had a sensitivity of 57.2% and a specificity of 100%. High serum ferritin had a sensitivity of 85.7% and a specificity of 85.7%. All cases with serum ferritin ≥275.5 ng/mL and high RER were 8-oxo-dG- and iron staining-positive. Additionally, GS positivity was seen in all cases with "serum ferritin levels above the upper limits or iron staining-positive" and '8-oxo-dG high' cases. Therefore, combining serum ferritin levels with RER may increase the accuracy with which activated Wnt/β-catenin signaling is predicted in NAFLD-HCC. We suggest that 8-oxo-dG accumulates following increased oxidative stress due to hepatic tissue iron deposition; this may activate Wnt/β-catenin signaling and trigger carcinogenesis.

DOI PubMed

高齢者におけるMajor hepatectomyに伴う術後合併症にGeriatric Nutritional Risk Index(GNRI)で評価した栄養状態が及ぼす影響

加藤透, 永山稔, 木村康利, 今村将史, 久木田和晴, 村上武志, 水口徹, 竹政伊知朗

日本臨床外科学会雑誌 ( 日本臨床外科学会 ) 83 ( 3 ) 599 - 600 2022年03月

回腸瘻閉鎖術と腹腔鏡下肝切除術を同時施行した2例

永山稔, 木村康利, 今村将史, 村上武志, 加藤透, 久木田和晴, 伊東竜哉, 水口徹, 竹政伊知朗

日本外科感染症学会雑誌 ( (一社)日本外科感染症学会 ) 18 ( 1 ) 252 - 252 2021年11月

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