Misc - OONISHI Hirofumi

PJ-642 A Polymorphism in Promoter Region of CYP4A11 Gene is Associated with a New Onset of Hypertension : the Tanno-Sobetsu Study(Hypertension, basic-3, The 71st Annual Scientific Meeting of the Japanese Circulation Society)

Akasaka Hiroshi, Sugimoto Ken, Katsuya Tomohiro, Saitoh Shigeyuki, Ohnishi Hirofumi, Rakugi Hiromi, Ura Nobuyuki, Ogihara Toshio, Shimamoto Kazuaki

Circulation journal : official journal of the Japanese Circulation Society ( Japanese Circulation Society )  71   632 - 632  2007.03

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A polymorphism in promoter region of cytochrome P450 4A11 gene is associated with a new onset of hypertension: the Tanno and Sobetsu study

Hiroshi Akasaka, Ken Sugimoto, Tomohiro Katsuya, Shigeyuki Saitch, Hirofumi Ohnishi, Toshio Ogihara, Kazuaki Shimamoto

JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY ( ELSEVIER SCIENCE INC )  49 ( 9 ) 414A - 414A  2007.03

Research paper, summary (international conference)  

地域一般住民における腹部肥満およびメタボリックシンドロームからの2型糖尿病発症リスクに関する検討-端野 壮瞥町研究より

大西浩文

糖尿病   49 ( 1 ) s - 50  2007

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Accumulation of risk factors in individuals with abdominal obesity in a rural Japanese population: The Tanno and Sobetsu study

Hirofumi Ohnishi, Shigeyuki Saitoh, Satoru Takagi, Nobuo Katoh, Hiroshi Akasaka, Yosuke Nakamura, Kaneto Mitsumata, Mizue Okabe, Kazuaki Shimamoto

JOURNAL OF HYPERTENSION ( LIPPINCOTT WILLIAMS & WILKINS )  24   386 - 386  2006.12

Research paper, summary (international conference)  

Metabolic syndrome is a significant risk factor for atherosclerosis beyond cholesterol in Japanese

Satoru Takagi, Shigeyuki Saitoh, Hirofumi Ohnishi, Hiroshi Akasaka, Kazuaki Shimamoto

JOURNAL OF HYPERTENSION ( LIPPINCOTT WILLIAMS & WILKINS )  24   385 - 385  2006.12

Research paper, summary (international conference)  

Post-challenge hyperglycemia causes arteriosclerosis if fasting glucose level is normal.

Satoru Takagi, Shigeyuki Saitoh, Hirofumi Ohnishi, Hiroshi Akasaka, Kazuaki Shimamoto

JOURNAL OF HYPERTENSION ( LIPPINCOTT WILLIAMS & WILKINS )  24   223 - 223  2006.12

Research paper, summary (international conference)  

Incidence of hypertension in individuals with abdominal obesity in a rural Japanese population: The tanno and sobetsu study

Hirofumi Ohnishi, Shigeyuki Saitoh, Satoru Takagi, Nobuo Katoh, Hiroshi Akasaka, Yosuke Nakamura, Kaneto Mitsumata, Mizue Okabe, Kazuaki Shimamoto

JOURNAL OF HYPERTENSION ( LIPPINCOTT WILLIAMS & WILKINS )  24   63 - 63  2006.12

Research paper, summary (international conference)  

Relationship between gene polymorphisms in beta-2 and beta-3 adrenergic receptors and metabolic syndrome: The tanno and sobetsu study

Hiroshi Akasaka, Tomohiro Katsuya, Ken Sugimoto, Shigeyuki Saitoh, Hirofumi Ohnishi, Nobuyuki Ura, Hiromi Rakugi, Toshio Ogihara, Kazuaki Shimamoto

JOURNAL OF HYPERTENSION ( LIPPINCOTT WILLIAMS & WILKINS )  24   174 - 174  2006.12

Research paper, summary (international conference)  

心血管疾患危険因子からみた腹部超音波法による内臓脂肪量評価の試み : 端野・壮瞥町研究

千葉 雄, 斉藤 重幸, 高木 覚, 大西 浩文, 加藤 伸郎, 赤坂 憲, 中村 陽介, 島本 和明

肥満研究 : 日本肥満学会誌 = Journal of Japan Society for the Study of Obesity ( 日本肥満学会 )  12 ( 2 ) 142 - 146  2006.08

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FRS-107 Incidence of Diabetes Mellitus in Subjects with Metabolic Syndrome in a Rural Japanese Population : The Tanno and Sobetsu Study(Progress in Preventive Medicine-2 (H) FRS22,Featured Research Session (English),The 70th Anniversary Annual Scientific Meeting of the Japanese Circulation Society)

Ohnishi Hirofumi, Saitoh Shigeyuki, Takagi Satoru, Katoh Nobuo, Chiba Yu, Akasaka Hiroshi, Nakamura Yosuke, Shimamoto Kazuaki

Circulation journal : official journal of the Japanese Circulation Society ( Japanese Circulation Society )  70   140 - 140  2006.03

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Study of visceral fat measurement using ultrasonography and cardiovascular disease risk factors: the Tanno and Sobetu study

斎藤 重幸, 高木 覚, 大西 浩文

研究助成論文集 ( 健康管理事業団 )  ( 22 ) 29 - 36  2006

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臨床・医薬品情報データベースシステムの将来像 形態学的解析に基づくコンテキスト指向データベース技術の医療・医学への応用

新見 隆彦, 辰巳 治之, 明石 浩史, 大西 浩文, 戸倉 一, 中村 正弘, 岡崎 光洋, 三浦 光貴, 若狭 敏樹

医療情報学連合大会論文集 ( (一社)日本医療情報学会 )  25回   471 - 474  2005.11

Relation of hypertension and glucose tolerance impairment in elderly people to the development of arteriosclerosis : Investigation using pulse wave velocity

ISOBE Takeshi, SAITOH Shigeyuki, TAKAGI Satoru, OHNISHI Hirofumi, OHHATA Junichi, TAKEUCHI Hiroshi, CHIBA Yu, KATOH Nobuo, FUJIWARA Tadashi, AKASAKA Hiroshi, SHIMAMOTO Kazuaki

Geriatrics & gerontology international   5 ( 1 ) 10 - 16  2005.03

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Incidence of insulin resistance in obese subjects in a rural Japanese population: The Tanno and Sobetsu study

H Ohnishi, S Saitoh, S Takagi, J Ohata, H Takeuchi, T Isobe, N Katoh, Y Chiba, T Fujiwara, H Akasaka, K Shimamoto

DIABETES OBESITY & METABOLISM ( BLACKWELL PUBLISHING LTD )  7 ( 1 ) 83 - 87  2005.01

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Objectives: Although it is well known that obesity is closely related to insulin resistance, the incidence of the development of insulin resistance in people with obesity is not known. In this study, we investigated the incidence of insulin resistance in citizens of two rural communities in Japan. Subjects and methods: The subjects were 102 men and 126 women over the age of 30 years selected from 1035 citizens who had undergone medical examinations in the towns of Tanno and Sobetsu, Hokkaido, in 1991 and 1998. Those who were on medication for hypertension, diabetes, hyperlipidaemia, coronary heart disease and cerebral vessel disease were excluded. The simple index to determine insulin resistance [i.e. homeostasis model assessment (HOMA-R) greater than or equal to 1.73] was used, and subjects who were determined to be positive for insulin resistance according to this index in 1991 were also excluded in order to determine the incidence of insulin resistance in subjects who had no abnormalities other than obesity. The systolic blood pressure (SBP), diastolic blood pressure, body mass index (BMI), triglyceride level, high-density lipoprotein level, blood sugar level, serum insulin value and HOMA-R were measured in all subjects in 1991 and in 1998. Moreover, the subjects were divided into two groups according to BMI, a normal group consisting of subjects with BMI < 25 and an obesity group consisting of subjects with BMI greater than or equal to 25. We also compared the incidences of insulin resistance in normal and obesity groups of subjects who were newly determined to be positive for insulin resistance on the basis of data obtained from medical examinations conducted in 1998. Results: The incidence of insulin resistance was significantly higher in the obesity group than in the normal group (25.0 vs. 4.5%). The results of logistic regression analysis showed that obesity was closely related to insulin resistance and that the relative risk of development of insulin resistance adjusted for age, sex, SBP, FPG and HDL was 3.193 (95% CI 1.085-9.401). Conclusions: The incidence of insulin resistance was significantly higher in the obesity group than in the normal group in this study, suggesting that improvement in obesity is important for prevention of the occurrence of type 2 diabetes or atherosclerotic disease based on insulin resistance.

DOI

Risk factors for heavy burden among family caregivers in a rural town in Hokkaido

Masakazu Washio, Shigeyuki Saitoh, Yumiko Arai, Satoru Takagi, Hirofumi Oonishi, Takeshi Isobe, Hiroshi Takeuchi, Junichi Oohata, Mitsuru Mori, Kazuaki Shimamoto

Japanese Journal of Geriatrics ( Japan Geriatrics Society )  42 ( 2 ) 221 - 228  2005

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Objective: The present study was conducted in order to investigate risk factors for heavy burden of family caregivers. Study design: Cross-sectional study. Participants: 51 pairs of the frail elderly and their family caregivers in one town in Hokkaido. Results: Compared to those with a lighter burden, family caregivers with heavier burden looked after the frail elderly with more behavior disturbances due to dementia. They cared for the elderly longer and had less time to go out without accompanying their charges than less burdened caregivers. On the other hand, the elderly had similar activities of daily living and degree of need of care between the two groups. In addition, physical caring time did not differ between the two groups. These findings suggest that the psychological burden may be more important than the physical burden. In addition, caregivers used only 30-40% of services they had the right to use with long-term care insurance. These findings suggest that more convenient services for users should be provided.

DOI PubMed CiNii

Risk factors for heavy burden among family caregivers in a rural town in Hokkaido

Masakazu Washio, Shigeyuki Saitoh, Yumiko Arai, Satoru Takagi, Hirofumi Oonishi, Takeshi Isobe, Hiroshi Takeuchi, Junichi Oohata, Mitsuru Mori, Kazuaki Shimamoto

Japanese Journal of Geriatrics ( Japan Geriatrics Society )  42 ( 2 ) 221 - 228  2005

　View Summary

Objective: The present study was conducted in order to investigate risk factors for heavy burden of family caregivers. Study design: Cross-sectional study. Participants: 51 pairs of the frail elderly and their family caregivers in one town in Hokkaido. Results: Compared to those with a lighter burden, family caregivers with heavier burden looked after the frail elderly with more behavior disturbances due to dementia. They cared for the elderly longer and had less time to go out without accompanying their charges than less burdened caregivers. On the other hand, the elderly had similar activities of daily living and degree of need of care between the two groups. In addition, physical caring time did not differ between the two groups. These findings suggest that the psychological burden may be more important than the physical burden. In addition, caregivers used only 30-40% of services they had the right to use with long-term care insurance. These findings suggest that more convenient services for users should be provided.

DOI PubMed CiNii

一般住民における高齢糖尿病者の生命予後：NIPPON DATA90より

齋藤重行, 大西浩文, 高木覚, 島本和明, 上島弘嗣, 岡村智教, 岡山明, 小野田敏行, 坂田清美, NIPPON DATA解析グループ

日本老年医学会雑誌   42   85 - 85  2005

Research paper, summary (national, other academic conference)  

すぐに役立つ臨床医のためのIT情報(11)遠隔医療のIT利活用の展望--十勝プロジェクトから

戸倉 一, 大西 浩文, 明石 浩史

クリニカルプラクティス ( エルゼビア・ジャパン )  23 ( 12 ) 1246 - 1249  2004.12

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Adiponectin levels and coronary risk factors in the elderly

ISOBE Takeshi, SAITOH Shigeyuki, TAKAGI Satoru, OHNISHI Hirofumi, OHHATA Junichi, TAKEUCHI Hiroshi, FUJIWARA Tadashi, HIGASHIURA Katsuhiro, URA Nobuyuki, SHIMAMOTO Kazuaki

Japanese journal of geriatrics ( 日本老年医学会 )  41 ( 3 ) 328 - 333  2004.05

DOI CiNii

Post-challenge hyperglycemia results in accumulation of risk factors and acceleration of cardiovascular morbidity

S Takagi, S Saitoh, J Ohata, H Ohnishi, H Takeuchi, T Isobe, N Katoh, Y Chiba, T Fujiwara, H Akasaka, Y Nakamura, K Shimamoto

JOURNAL OF HYPERTENSION ( LIPPINCOTT WILLIAMS & WILKINS )  22   S107 - S107  2004.02

Research paper, summary (international conference)