Updated on 2025/08/22

写真a

 
SUMI Aako
 
Organization
Medical Development Center Dean Department of Liberal Arts and Sciences Physics Professor
Title
Professor
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Degree

  • Ph.D ( Hokkaido University )

Research Interests

  • Mathematical biology Epidemiology of infectious diseases Nonlinear science Time series analysis

Research Areas

  • Natural Science / Biophysics, chemical physics and soft matter physics

Education

  • Hokkaido University   Faculty of Science (Geophysics)   B.S.

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    Country： Japan

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  • Kobe University   Graduate School of Science   M.S.

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    Country： Japan

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  • Hokkaido University   School of Medicine   Ph.D.

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Research History

  • 札幌医科大学 医学部 衛生学講座 准教授

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  • 札幌医科大学 医学部 衛生学講座 講師

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  • 札幌医科大学 医学部 衛生学講座 助手

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  • デンマーク国立オーデンセ大学

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  • 日本学術振興会特別研究員（PD）

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  • 日本学術振興会特別研究員（DC）

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Professional Memberships

Papers

  • Spectral study of COVID-19 pandemic in Japan: the dependence of spectral gradient on the population size of the community Reviewed

    Ayako Sumi, Masayuki Koyama, Manato Katagiri, Norio Ohtomo

    PLoS ONE   20 ( 1 )   e0314233   2025.1

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    Authorship：Lead author,　Corresponding author   Publishing type：Research paper (scientific journal)  

    DOI： 10.1371/journal.pone.0314233

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  • Time series analysis of daily reported number of new positive cases of COVID-19 in Japan from January 2020 to February 2023 Reviewed

    Ayako Sumi

    PLoS ONE   2023.9

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    Authorship：Lead author,　Corresponding author   Publishing type：Research paper (scientific journal)  

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  • Associations between Meteorological Factors and Reported Mumps Cases from 1999 to 2020 in Japan Reviewed

    Keiji Mise, Ayako Sumi, Shintaro Takatsuka, Shin-ichi Toyoda

    Epidemiologia   2 ( 2 )   162 - 178   2021.4

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    Authorship：Corresponding author   Publishing type：Research paper (scientific journal)   Publisher：MDPI AG  

    The present study investigated associations between epidemiological mumps patterns and meteorological factors in Japan. We used mumps surveillance data and meteorological data from all 47 prefectures of Japan from 1999 to 2020. A time-series analysis incorporating spectral analysis and the least-squares method was adopted. In all power spectral densities for the 47 prefectures, spectral lines were observed at frequency positions corresponding to 1-year and 6-month cycles. Optimum least-squares fitting (LSF) curves calculated with the 1-year and 6-month cycles explained the underlying variation in the mumps data. The LSF curves reproduced bimodal and unimodal cycles that are clearly observed in northern and southern Japan, respectively. In investigating factors associated with the seasonality of mumps epidemics, we defined the contribution ratios of a 1-year cycle (Q1) and 6-month cycle (Q2) as the contributions of amplitudes of 1-year and 6-month cycles, respectively, to the entire amplitude of the time series data. Q1 and Q2 were significantly correlated with annual mean temperature. The vaccine coverage rate of a measles–mumps–rubella vaccine might not have affected the 1-year and 6-month modes of the time series data. The results of the study suggest an association between mean temperature and mumps epidemics in Japan.

    DOI： 10.3390/epidemiologia2020013

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  • Clonal lineages and antimicrobial resistance of nonencapsulated Streptococcus pneumoniae in the post-pneumococcal conjugate vaccine era in Japan. International journal

    Mitsuyo Kawaguchiya, Noriko Urushibara, Meiji Soe Aung, Kenji Kudo, Masahiko Ito, Ayako Sumi, Nobumichi Kobayashi

    International journal of infectious diseases : IJID : official publication of the International Society for Infectious Diseases   105   695 - 701   2021.3

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    Language：English   Publishing type：Research paper (scientific journal)  

    OBJECTIVES: The emergence and spread of nonencapsulated Streptococcus pneumoniae (NESp) is a public health concern in the post-pneumococcal conjugate vaccine era. We analyzed the prevalence, molecular characteristics, and antimicrobial resistance of NESp responsible for non-invasive infections in northern Japan. METHODS: Among 4463 S. pneumoniae isolates collected from non-invasive infection cases during four study periods between January 2011 and January 2019, NESp isolates were identified using molecular and phenotypical methods. NESp isolates were analyzed for antimicrobial susceptibility, genotype, and virulence-associated genes. RESULTS: A total of 71 NESp isolates were identified (1.6% of all the clinical isolates) and assigned to the null capsule clade (NCC)1 (pspK+) (94.4%) or NCC2 (aliC+/aliD+) (5.6%). Five dominant sequence types (STs) were ST7502 (23.9%), ST4845 (19.7%), ST16214 (11.3%), ST11379 (9.9%), and ST7786 (7.0%). These dominant STs and all seven novel STs were related to the sporadic NESp lineage ST1106 or PMEN clone Denmark14-ST230. High non-susceptibility rates of NESp were observed for trimethoprim-sulfamethoxazole, erythromycin, and tetracycline (>92.9%), and multidrug resistance was observed in 88.7% of the NESp isolates, including all the ST7502, ST4845, and ST11379 isolates. CONCLUSIONS: The present study revealed that the dominant clonal groups of NESp were associated with a high prevalence of non-susceptibility to antimicrobials in northern Japan.

    DOI： 10.1016/j.ijid.2021.02.109

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  • New Development of Disaster-Related and Tropical Infectious Diseases Control Reviewed

    Gaowa Bai, Toshiro Niki, Haruhisa Kikuchi, Ayako Sumi, Nobuyuki Kobayashi, Takahiro Haruyama, Jing Zhang, Haorile Chagan-Yasutan, Toshio Hattori

    Reports — Medical Cases, Images, and Videos   3 ( 1 )   5 - 5   2020.3

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    Language：English   Publishing type：Research paper (scientific journal)   Publisher：MDPI AG  

    As described in Japanese essay (Hojoki), written around 1200, various disasters such as big fires, earthquakes, and famines have occurred in Japan. Asian countries have been suffering from the disasters; furthermore, natural disasters are increasing due to global warming. Because tropical-infectious diseases are often disaster-related infectious diseases (DRIDs), the strategies against the former kind of disease could be applicable to DRIDs. Meteorological analysis of the occurrence of DRIDs using a method of time series analysis is important. In situations of disasters, it is desirable if you can identify the pathogen and identify disease severity simultaneously. A dipstick DNA chromatography assay termed as Single-Tag Hybridization—Printed Array Strip (STH—PAS) system was developed based on the DNA sequences of various mosquito-borne diseases. The plasma levels of matricellular proteins including galectin-9 (Gal-9) and osteopontin (OPN) were found to reflect the disease severities in the dengue virus and other DIRDs. Because both proteins have been reported to be immune-check molecules, their inhibition might enhance the immune system against pathogens. We found that brefelamide derivatives could inhibit OPN and other inflammatory molecules synthesis. Very recently, different derivatives were found to inhibit PD-L1 transcription. Applications of these agents should be considered as multi-step strategies against DRIDs.

    DOI： 10.3390/reports3010005

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  • Clonal Diversity and Genetic Characteristics of Methicillin-Resistant Staphylococcus aureus Isolates from a Tertiary Care Hospital in Japan. International journal

    Meiji Soe Aung, Noriko Urushibara, Mitsuyo Kawaguchiya, Ayako Sumi, Masaaki Shinagawa, Satoshi Takahashi, Nobumichi Kobayashi

    Microbial drug resistance (Larchmont, N.Y.)   25 ( 8 )   1164 - 1175   2019.10

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    Molecular epidemiological characteristics were investigated for 1,041 isolates of methicillin-resistant Staphylococcus aureus (MRSA) collected in a tertiary care hospital in northern Japan for a 4-year period (2011-2014). Genotypes (staphylococcal cassette chromosome mec [SCCmec], sequence type, spa, coa, etc.) and the presence of drug resistance/virulence factor genes in the isolates were analyzed by multiplex/uniplex PCR, and PCR-direct sequencing as needed. Among these MRSA, predominant SCCmec type was IIa (87.2%), followed by IV (10.1%) and V (1.2%). The SCCmec IIa-MRSA belonged to coagulase genotype (coa) IIa and ST5/ST764, which are known as major health care-associated-MRSA (HA-MRSA) in Japan (New York/Japan clone) and its variant. Panton-Valentine leucocidine (PVL) genes were detected in only five isolates (0.5%) with genotypes ST8-SCCmec IVa/spa-t008/coa-IIIa (USA300 clone), ST6-SCCmec IVb, and ST59-SCCmec V (Taiwanese clone). Arginine catabolic mobile element (ACME) type I and II' were identified in three and five isolates of ST8-SCCmec IVa and ST764-SCCmec IIa MRSA, respectively. PVL-/ACME- isolates were classified into various STs/clonal complexes (CCs), with CC1, CC5, CC8, CC89, and CC121 being common. It was notable that SCCmec IVl was the most common among SCCmec IV subtypes, and was carried by almost half of coa-IIIa isolates (47%, 34/72) without PVL genes, which represented the novel ST8 MRSA clone spreading in Japan (i.e., "ST8/CA-MRSA/J"). Uncommon MRSA clones in Japan, ST72-SCCmec IV (South Korean clone), ST398 livestock-associated clone, and ST20 bovine-associated MRSA, were identified. Furthermore, we isolated PVL-negative ST8-SCCmec I/coa-IIIa and ST81-SCCmec V/coa-VIIa MRSA, which were considered presumptive novel clones. The present study revealed the genetic diversity of HA-MRSA, including potentially emerging clones of putative different origins.

    DOI： 10.1089/mdr.2018.0468

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  • Molecular Epidemiological Characterization of Staphylococcus argenteus Clinical Isolates in Japan: Identification of Three Clones (ST1223, ST2198, and ST2550) and a Novel Staphylocoagulase Genotype XV. International journal

    Meiji Soe Aung, Noriko Urushibara, Mitsuyo Kawaguchiya, Ayako Sumi, Seika Takahashi, Miyo Ike, Masahiko Ito, Satoshi Habadera, Nobumichi Kobayashi

    Microorganisms   7 ( 10 )   2019.9

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    Staphylococcus argenteus, a novel emerging species within Staphylococcus aureus complex (SAC), has been increasingly reported worldwide. In this study, prevalence of S. argenteus among human clinical isolates, and their clonal diversity and genetic characteristics of virulence factors were investigated in Hokkaido, the northern main island of Japan. During a four-month period starting from March 2019, twenty-four S. argenteus and 4330 S. aureus isolates were recovered from clinical specimens (the ratio of S. argenteus to S. aureus :0.0055). Half of S. argenteus isolates (n = 12) belonged to MLST sequence type (ST) 2250 and its single-locus variant, with staphylocoagulase genotype (coa-) XId, while the remaining isolates were assigned to ST2198/coa-XIV (n = 6), and ST1223 with a novel coa-XV identified in this study (n = 6). All the isolates were mecA-negative, and susceptible to all the antimicrobials tested, except for an ST2198 isolate with blaZ and an ST2250 isolate with tet(L) showing resistance to ampicillin and tetracyclines, respectively. Common virulence factors in the S. argenteus isolates were staphylococcal enterotoxin (-like) genes sey, selz, sel26, and sel27 in ST2250, selx in ST2198, and enterotoxin gene cluster (egc-1: seg-sei-sem-sen-seo) in ST1223 isolates, in addition to hemolysin genes (hla, hlb, and hld) distributed universally. Elastin binding protein gene (ebpS) and MSCRAMM family adhesin SdrE gene (sdrE) detected in all the isolates showed high sequence identity among them (> 97%), while relatively lower identity to those of S. aureus (78-92%). Phylogenetically, ebpS, sdrE, selx, sey, selw, sel26, and sel27 of S. argenteus formed clusters distinct from those of S. aureus, unlike sec, selz, tst-1, and staphylokinase gene (sak). The present study revealed the prevalence of S. argenteus among clinical isolates, and presence of three distinct S. argenteus clones (ST2250; ST2198 and ST1223) harboring different virulence factors in northern Japan. ST2198 S. argenteus, a minor clone (strain BN75-like) that had been rarely reported, was first identified in Japan as human isolates.

    DOI： 10.3390/microorganisms7100389

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  • Prevalence and Genetic Diversity of Toxin Genes in Clinical Isolates of Clostridium perfringens: Coexistence of Alpha-Toxin Variant and Binary Enterotoxin Genes (bec/cpile). International journal

    Asami Matsuda, Meiji Soe Aung, Noriko Urushibara, Mitsuyo Kawaguchiya, Ayako Sumi, Mayumi Nakamura, Yuka Horino, Masahiko Ito, Satoshi Habadera, Nobumichi Kobayashi

    Toxins   11 ( 6 )   2019.6

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    Language：English   Publishing type：Research paper (scientific journal)  

    Clostridium perfringens (C. perfringens) is responsible for food-borne gastroenteritis and other infectious diseases, and toxins produced by this bacterium play a key role in pathogenesis. Although various toxins have been described for C. perfringens isolates from humans and animals, prevalence of individual toxins among clinical isolates has not yet been well explored. In the present study, a total of 798 C. perfringens clinical isolates were investigated for prevalence of eight toxin genes and their genetic diversity by PCR, nucleotide sequencing, and phylogenetic analysis. Besides the alpha-toxin gene (plc) present in all the isolates, the most common toxin gene was cpe (enterotoxin) (34.2%), followed by cpb2 (beta2 toxin) (1.4%), netB (NetB) (0.3%), and bec/cpile (binary enterotoxin BEC/CPILE) (0.1%), while beta-, epsilon-, and iota-toxin genes were not detected. Genetic analysis of toxin genes indicated a high level of conservation of plc, cpe, and netB. In contrast, cpb2 was revealed to be considerably divergent, containing at least two lineages. Alpha-toxin among 46 isolates was classified into ten sequence types, among which common types were distinct from those reported for avian isolates. A single isolate with bec/cpile harbored a plc variant containing an insertion of 834-bp sequence, suggesting its putative origin from chickens.

    DOI： 10.3390/toxins11060326

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  • Time-series analysis of geographically specific monthly number of newly registered cases of active tuberculosis in Japan Reviewed

    Sumi A, Kobayashi N

    PLoS ONE   14 ( 3 )   e0213856   2019.3

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    Authorship：Corresponding author   Language：English   Publishing type：Research paper (scientific journal)  

    DOI： 10.1371/journal.pone.0213856

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  • Molecular characterization of Staphylococcus argenteus in Myanmar: identification of novel genotypes/clusters in staphylocoagulase, protein A, alpha-haemolysin and other virulence factors. International journal

    Meiji Soe Aung, Thida San, Nilar San, Win Mar Oo, Phyoe May Ko, Khin Thet Thet, Noriko Urushibara, Mitsuyo Kawaguchiya, Ayako Sumi, Nobumichi Kobayashi

    Journal of medical microbiology   68 ( 1 )   95 - 104   2019.1

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    PURPOSE: Staphylococcus argenteus is a novel emerging species of coagulase-positive staphylococcus that is genetically closely related to Staphylococcus aureus. To elucidate the molecular differences in the virulence factors (staphylocoagulase, protein A, alpha-haemolysin, enterotoxin-like toxin and staphylokinase) between these staphylococcal species, S. argenteus that had recently been isolated in Myanmar (five nasal isolates and four clinical isolates) were analysed. METHODOLOGY: The nucleotide sequences of the virulence factors were determined by PCR and direct sequencing, followed by phylogenetic analysis by mega6 and multiple alignment by clustalw using the published sequence data for S. aureus and S. argenteus. RESULTS: Six S. argenteus isolates belonged to MLST sequence type (ST) 2250, while others belonged to ST4625, ST2198 and ST2854. The novel staphylocoagulase (coa) genotype XIV and the novel coa-XI subtype (XId) were identified in an ST2198 isolate and all other isolates, respectively. Among the S. argenteus isolates, the protein A and alpha-haemolysin genes showed high sequence identity (96-98 % and >99 %, respectively), while lower identity was observed between S. argenteus and S. aureus (88-91 % and 86 %, respectively), with both species showing phylogenetically distinct clusters. Similar findings were found for the staphylococcal enterotoxin (SE)-like toxin genes selw, selx and sely. In contrast, the staphylokinase genes were almost identical between these two species. All of the coa-XId isolates had a CRISPR/Cas locus at the site of orfX without having SCCmec, whereas an ST2198 isolate lacked this locus. CONCLUSION: The primary virulence factors (staphylocoagulase, protein A andalpha-haemolysin) as well as the SE-like toxins of S. argenteus were genetically discriminated from those of S. aureus, revealing the presence of the novel coa-type/subtype (coa-IXd, XIV) in S. argenteus.

    DOI： 10.1099/jmm.0.000869

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  • Prevalence of Extended-Spectrum Beta-Lactamase and Carbapenemase Genes in Clinical Isolates of Escherichia coli in Myanmar: Dominance of blaNDM-5 and Emergence of blaOXA-181. International journal

    Meiji Soe Aung, Nilar San, Win Win Maw, Thida San, Noriko Urushibara, Mitsuyo Kawaguchiya, Ayako Sumi, Nobumichi Kobayashi

    Microbial drug resistance (Larchmont, N.Y.)   24 ( 9 )   1333 - 1344   2018.11

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    The increasing trend of Escherichia coli producing extended-spectrum beta-lactamases (ESBLs) and carbapenemases is a global public health concern. In this study, prevalence and molecular characteristics of E. coli harboring ESBL and carbapenemase genes were investigated for 426 isolates derived from various clinical specimens in a teaching hospital in Yangon, Myanmar, for the 1-year period beginning January 2016. A total of 157 isolates (36.9%) were ESBL producers and harbored CTX-M-1 group genes (146 isolates; blaCTX-M-15, blaCTX-M55) or CTX-M-9 group genes (11 isolates; blaCTX-M-14, blaCTX-M-27). Carbapenem resistance was detected in 35 isolates (8.2%), among which 26 isolates had carbapenemase genes encoding NDM-1 (2 isolates), NDM-4 (6 isolates), NDM-5 (14 isolates), NDM-7 (3 isolates), and OXA-181 (2 isolates). blaNDM-5 was identified in phylogenetic groups A, B1, and D isolates belonging to various genotypes (ST101, ST354, ST405, ST410, ST1196) associated with blaTEM-1, blaCTX-M-15, blaOXA-181, blaCMY-2, blaCMY-6, blaCMY-42, qnrB, qnrS, or aac6'-Ib-cr. While two isolates with blaOXA-181 belonged to phylogenetic group A-ST410, one isolate had also blaNDM-5, as well as blaCTX-M-15 and blaCMY-2, and the other harbored blaCMY-42 and aac6'-Ib-cr, showing different resistance patterns. Phylogenetic group B2 isolates examined were classified into mostly ST131 and had solely blaCTX-M-15 or blaCTX-M-27, harboring more virulence factors than other phylogenetic groups. The present study revealed high prevalence of ESBL genes represented by blaCTX-M-15 and dominance of blaNDM-5 among NDM genes, disseminating to various E. coli clones. Notably, carbapenemase gene encoding OXA-181 was first identified in Myanmar, suggesting its spread together with NDM genes.

    DOI： 10.1089/mdr.2017.0387

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  • Role of temperature in reported chickenpox cases in northern European countries: Denmark and Finland Reviewed

    Ayako Sumi

    BMC Research Notes   11 ( 1 )   377 - 382   2018.6

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    Authorship：Corresponding author   Language：English   Publishing type：Research paper (scientific journal)   Publisher：BioMed Central Ltd.  

    DOI： 10.1186/s13104-018-3497-0

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  • ミャンマーの大腸菌臨床分離株におけるESBL・カルバペネマーゼ遺伝子の分布状況

    小林 宣道, アウン・メイジソウ, サン・ニラ, モウ・ウィンウィン, 川口谷 充代, 漆原 範子, 鷲見 紋子

    日本衛生学雑誌   73 ( Suppl. )   S261 - S261   2018.3

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    Language：Japanese   Publisher：(一社)日本衛生学会  

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  • Association between meteorological factors and reported cases of hand, foot, and mouth disease from 2000 to 2015 in Japan Reviewed

    A. Sumi, S. Toyoda, K. Kanou, T. Fujimoto, K. Mise, Y. Kohei, A. Koyama, N. Kobayashi

    EPIDEMIOLOGY AND INFECTION   145 ( 14 )   2896 - 2911   2017.10

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    Authorship：Corresponding author   Language：English   Publishing type：Research paper (scientific journal)  

    DOI： 10.1017/S0950268817001820

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  • Role of meteorological conditions in reported chickenpox cases in Wuhan and Hong Kong, China Reviewed

    Banghua Chen, Ayako Sumi, Lei Wang, Wang Zhou, Nobumichi Kobayashi

    BMC INFECTIOUS DISEASES   17   538 - 546   2017.8

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    Authorship：Corresponding author   Language：English   Publishing type：Research paper (scientific journal)  

    DOI： 10.1186/s12879-017-2640-1

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  • Molecular Characterization of Methicillin-Resistant Staphylococcus aureus from Outpatients in Northern Japan: Increasing Tendency of ST5/ST764 MRSA-IIa with Arginine Catabolic Mobile Element Reviewed

    Meiji Soe Aung, Mitsuyo Kawaguchiya, Noriko Urushibara, Ayako Sumi, Masahiko Ito, Kenji Kudo, Shigeo Morimoto, Shino Hosoya, Nobumichi Kobayashi

    MICROBIAL DRUG RESISTANCE   23 ( 5 )   616 - 625   2017.7

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    Language：English   Publishing type：Research paper (scientific journal)  

    DOI： 10.1089/mdr.2016.0176

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  • Effect of temperature, relative humidity and rainfall on dengue fever and leptospirosis infections in Manila, the Philippines Reviewed

    A. Sumi, E. F. O. Telan, H. Chagan-Yasutan, M. B. Piolo, T. Hattori, N. Kobayashi

    EPIDEMIOLOGY AND INFECTION   145 ( 1 )   78 - 86   2017.1

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    Authorship：Corresponding author   Language：English   Publishing type：Research paper (scientific journal)  

    DOI： 10.1017/S095026881600203X

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  • Collaborative Research on Puerperal Infections in Bangladesh.

    Nobumichi Kobayashi, Salma Ahmed, Ayako Sumi, Noriko Urushibara, Mitsuyo Kawaguchiya, Meiji Soe Aung

    Nihon eiseigaku zasshi. Japanese journal of hygiene   72 ( 2 )   106 - 111   2017

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    Language：Japanese   Publishing type：Research paper (scientific journal)  

    Bangladesh is considered as a high-risk country for emerging infectious diseases because of its high population density, poverty, and unhygienic conditions. Although control efforts have primarily been focused on major infectious diseases such as diarrheal diseases, tuberculosis, malaria, and HIV infection, the prevalence and impact of many local or minor infectious diseases are still unclarified in this country. In this review, we present our recent experience and outcomes of collaborative research on puerperal infection (PI), which is a poorly defined infectious disease in Bangladesh. PI is the most common complication during the perinatal period in developing countries. We investigated the incidence of individual species of aerobic bacteria causing PIs and their drug resistance, and the genetic traits of isolates during the two-year period (2010-2012). The common species of isolates from patients with PIs were Escherichia coli, Enterococcus faecalis, Staphylococcus haemolyticus, Proteus mirabilis, Staphylococcus aureus, and Klebsiella pneumoniae. A remarkable finding was the high rates of resistance to cephalosporins among Gram-negative bacteria harboring extended-spectrum beta-lactamase genes, which were associated with carbapenem resistance in a few isolates. This study defined the importance of control of antimicrobial resistance in Bangladesh, and provided suggestions for the future direction of collaborative research on infectious diseases in Bangladesh.

    DOI： 10.1265/jjh.72.106

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  • Time-series analysis of monthly age-specific numbers of newly registered cases of active tuberculosis in Japan from 1998 to 2013 Reviewed

    Y. Kohei, A. Sumi, N. Kobayashi

    EPIDEMIOLOGY AND INFECTION   144 ( 11 )   2401 - 2414   2016.8

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    DOI： 10.1017/S0950268816000546

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  • バングラデシュにおける産褥期感染症由来の大腸菌と黄色ブドウ球菌の分子疫学的解析

    小林 宣道, アーメッド・サルマ, 川口谷 充代, 漆原 範子, メイジ・ソウアウン, 鷲見 紋子

    日本衛生学雑誌   71 ( Suppl. )   S215 - S215   2016.5

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    Ichushi

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  • Time series analysis of reported cases of hand, foot, and mouth disease from 2010 to 2013 in Wuhan, China Reviewed

    Banghua Chen, Ayako Sumi, Shin'ichi Toyoda, Quan Hu, Dunjin Zhou, Keiji Mise, Junchan Zhao, Nobumichi Kobayashi

    BMC INFECTIOUS DISEASES   15   495 - 509   2015.11

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    Authorship：Corresponding author   Language：English   Publishing type：Research paper (scientific journal)  

    DOI： 10.1186/s12879-015-1233-0

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  • The role of temperature in reported chickenpox cases from 2000 to 2011 in Japan Reviewed

    K. Harigane, A. Sumi, K. Mise, N. Kobayashi

    EPIDEMIOLOGY AND INFECTION   143 ( 12 )   2666 - 2678   2015.9

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    Authorship：Corresponding author   Language：English   Publishing type：Research paper (scientific journal)  

    DOI： 10.1017/S095026881400363X

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  • Seasonality of reported tuberculosis cases from 2006 to 2010 in Wuhan, China Reviewed

    T. Luo, A. Sumi, D. Zhou, N. Kobayashi, K. Mise, B. Yu, D. Kong, J. Wang, Q. Duan

    EPIDEMIOLOGY AND INFECTION   142 ( 10 )   2036 - 2048   2014.10

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    Authorship：Corresponding author   Language：English   Publishing type：Research paper (scientific journal)  

    DOI： 10.1017/S0950268813003142

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  • Effect of temperature, relative humidity and rainfall on rotavirus infections in Kolkata, India Reviewed

    A. Sumi, K. Rajendran, T. Ramamurthy, T. Krishnan, G. B. Nair, K. Harigane, N. Kobayashi

    EPIDEMIOLOGY AND INFECTION   141 ( 8 )   1652 - 1661   2013.8

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    Authorship：Corresponding author   Language：English   Publishing type：Research paper (scientific journal)  

    DOI： 10.1017/S0950268812002208

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  • Time-series analysis of hepatitis A, B, C and e infections in a large Chinese city: Application to prediction analysis Reviewed

    A. Sumi, T. Luo, D. Zhou, B. Yu, D. Kong, N. Kobayashi

    Epidemiology and Infection   141 ( 5 )   905 - 915   2013.5

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    Authorship：Corresponding author   Language：English   Publishing type：Research paper (scientific journal)  

    DOI： 10.1017/S095026881200146X

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  • MEM spectral analysis for predicting influenza epidemics in Japan Reviewed

    Ayako Sumi, Ken-Ichi Kamo

    Environmental Health and Preventive Medicine   17 ( 2 )   98 - 108   2012.3

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    Authorship：Corresponding author   Language：English   Publishing type：Research paper (scientific journal)  

    DOI： 10.1007/s12199-011-0223-0

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  • Study on the effect of measles control programmes on periodic structures of disease epidemics in a large Chinese city Reviewed

    T. Luo, A. Sumi, D. Zhou, K. Kamo, B. Yu, D. Zhao, K. Mise, N. Kobayashi

    EPIDEMIOLOGY AND INFECTION   139 ( 2 )   257 - 264   2011.2

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    DOI： 10.1017/S0950268810001056

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  • Influence of relative humidity in Vibrio cholerae infection: A time series model Reviewed

    K. Rajendran, A. Sumi, M. K. Bhattachariya, B. Manna, D. Sur, N. Kobayashi, T. Ramamurthy

    INDIAN JOURNAL OF MEDICAL RESEARCH   133 ( 2 )   138 - 145   2011.2

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  • Time Series Analysis of Incidence Data of Influenza in Japan Reviewed

    Ayako Sumi, Ken-ichi Kamo, Norio Ohtomo, Keiji Mise, Nobumichi Kobayashi

    JOURNAL OF EPIDEMIOLOGY   21 ( 1 )   21 - 29   2011.1

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    Language：English   Publishing type：Research paper (scientific journal)  

    DOI： 10.2188/jea.JE20090162

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  • Relationship of cholera incidence to El Nino and solar activity elucidated by time-series analysis Reviewed

    K. Ohtomo, N. Kobayashi, A. Sumi, N. Ohtomo

    EPIDEMIOLOGY AND INFECTION   138 ( 1 )   99 - 107   2010.1

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    Language：English   Publishing type：Research paper (scientific journal)  

    DOI： 10.1017/S0950268809990203

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  • Predicting the incidence of human campylobacteriosis in Finland with time series analysis Reviewed

    Ayako Sumi, Harri Hemila, Keiji Mise, Nobumichi Kobayashi

    APMIS   117 ( 8 )   614 - 622   2009.8

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    DOI： 10.1111/j.1600-0463.2009.02507.x

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  • Spectral Analysis of Spatial Series Data of Pathologic Tissue: A Study on Small Intestine in ICR Mouse Reviewed

    Keiji Mise, Ayako Sumi, Nobumichi Kobayashi, Toshihiko Torigoe, Norio Ohtomo

    JAPANESE JOURNAL OF APPLIED PHYSICS   48 ( 1 )   017001-1 - 017001-9   2009.1

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    Language：English   Publishing type：Research paper (scientific journal)  

    DOI： 10.1143/JJAP.48.017001

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  • Diversity of staphylocoagulase and identification of novel variants of staphylocoagulase gene in Staphylococcus aureus Reviewed

    Marie Kinoshita, Nobumichi Kobayashi, Shigeo Nagashima, Masaho Ishino, Seiko Otokozawa, Keiji Mise, Ayako Sumi, Hiroyuki Tsutsumi, Nobuyuki Uehara, Naoki Watanabe, Miyoko Endo

    MICROBIOLOGY AND IMMUNOLOGY   52 ( 7 )   334 - 348   2008.7

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    DOI： 10.1111/j.1348-0421.2008.00045.x

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  • Study of the effect of vaccination on periodic structures of measles epidemics in Japan Reviewed

    Ayako Sumi, Ken-ichi Kam, Norio Ohtomo, Nobumichi Kobayashi

    MICROBIOLOGY AND IMMUNOLOGY   51 ( 9 )   805 - 814   2007

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  • Proportion of sporadic gastroenteritis cases caused by rotavirus, norovirus, adenovirus and bacteria in Japan from January 2000 to December 2003 Reviewed

    A Sumi, N Kobayashi, N Ohtomo

    MICROBIOLOGY AND IMMUNOLOGY   49 ( 8 )   745 - 756   2005

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    Language：English   Publishing type：Research paper (scientific journal)  

    DOI： 10.1111/j.1348-0421.2005.tb03665.x

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  • Prediction analysis for measles epidemics Reviewed

    A Sumi, N Ohtomo, Y Tanaka, S Sawamura, LF Olsen, N Kobayashi

    JAPANESE JOURNAL OF APPLIED PHYSICS PART 1-REGULAR PAPERS SHORT NOTES & REVIEW PAPERS   42 ( 12 )   7611 - 7620   2003.12

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    Language：English   Publishing type：Research paper (scientific journal)  

    DOI： 10.1143/JJAP.42.7611

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  • Spectral study of measles epidemics: The dependence of spectral gradient on the population size of the community Reviewed

    A Sumi, LF Olsen, N Ohtomo, Y Tanaka, S Sawamura

    JAPANESE JOURNAL OF APPLIED PHYSICS PART 1-REGULAR PAPERS SHORT NOTES & REVIEW PAPERS   42 ( 2A )   721 - 733   2003.2

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    Language：English   Publishing type：Research paper (scientific journal)  

    DOI： 10.1143/JJAP.42.721

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  • Time Series Analysis for Incidence Data of Infectious Disease in Japan Reviewed

    Sumi A

    Hokkaido J. Med. Sci   73   743 - 763   1998

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  • Study on chaotic characteristics of incidence data of measles Reviewed

    A Sumi, N Ohtomo, Y Tanaka

    JAPANESE JOURNAL OF APPLIED PHYSICS PART 1-REGULAR PAPERS BRIEF COMMUNICATIONS & REVIEW PAPERS   36 ( 12A )   7460 - 7472   1997.12

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    Language：English   Publishing type：Research paper (scientific journal)  

    DOI： 10.1143/JJAP.36.7460

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  • Comprehensive spectral analysis of time series data of recurrent epidemics Reviewed

    A Sumi, N Ohtomo, Y Tanaka, A Koyama, K Saito

    JAPANESE JOURNAL OF APPLIED PHYSICS PART 1-REGULAR PAPERS BRIEF COMMUNICATIONS & REVIEW PAPERS   36 ( 3A )   1303 - 1318   1997.3

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    Language：English   Publishing type：Research paper (scientific journal)  

    DOI： 10.1143/JJAP.36.1303

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  • A detailed study of power spectral density for Rossler system Reviewed

    N Ohtomo, A Sumi, Y Tanaka, K Tokiwano, S Terachi

    JOURNAL OF THE PHYSICAL SOCIETY OF JAPAN   65 ( 9 )   2811 - 2823   1996.9

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    Language：English   Publishing type：Research paper (scientific journal)  

    DOI： 10.1143/JPSJ.65.2811

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  • EXPONENTIAL CHARACTERISTICS OF POWER SPECTRAL DENSITIES CAUSED BY CHAOTIC PHENOMENA Reviewed

    N OHTOMO, K TOKIWANO, Y TANAKA, A SUMI, S TERACHI, H KONNO

    JOURNAL OF THE PHYSICAL SOCIETY OF JAPAN   64 ( 4 )   1104 - 1113   1995.4

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    Language：English   Publishing type：Research paper (scientific journal)  

    DOI： 10.1143/JPSJ.64.1104

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Books

  • 時間感染症学

    鷲見, 紋子, 大友, 詔雄, 小林, 宣道

    北海道大学出版会  2020.2  （ ISBN:9784832982338 ）

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    Total pages：viii, 339p   Language：Japanese  

    CiNii Books

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Research Projects

  • 新型コロナウイルス感染症の時間的および空間的な流行動態に関する研究

    Grant number：22K10529  2022.4 - 2025.3

    日本学術振興会  科学研究費助成事業  基盤研究(C)

    鷲見 紋子, 小山 雅之

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    Grant amount：\4290000 （ Direct Cost: \3300000 、 Indirect Cost：\990000 ）

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  • 日本・中国・北欧における多剤耐性結核の時間的および空間的な流行動態に関する研究

    2019.4 - 2022.3

    文部科学省  科学研究費補助金（基盤研究(C)） 

    鷲見 紋子

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    Authorship：Principal investigator  Grant type：Competitive

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  • 時間感染症学

    2019.4 - 2020.3

    文部科学省  科学研究費補助金（学術図書） 

    鷲見 紋子

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    Authorship：Principal investigator  Grant type：Competitive

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  • 有酸素運動の運動強度の新たな指標に関する研究－ランニングの場合－

    2019.4 - 2020.3

    （公財）石本記念デサントスポーツ科学振興財団  自由課題学術研究 

    鷲見 紋子

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    Authorship：Principal investigator  Grant type：Competitive

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  • Analysis of present status and comprehensive molecular epidemiology of emerging drug-resistant bacteria in developing regions of Asia and Caribbean province

    Grant number：17H04664  2017.4 - 2020.3

    Japan Society for the Promotion of Science  Grants-in-Aid for Scientific Research  Grant-in-Aid for Scientific Research (B)

    Kobayashi Nobumichi

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    Grant amount：\17940000 （ Direct Cost: \13800000 、 Indirect Cost：\4140000 ）

    In three countries in Asia and Caribbean regions (Bangladesh, Myanmar, and Cuba) where information on antimicrobial resistance (AMR) is insufficient, resistance rates to various antimicrobials, prevalence of genes associated with AMR and virulence, genetic characteristics of drug-resistant isolates were analyzed for major pathogenic bacterial species (Escherichia coli, Klebsiella pneumoniae, Acinetobacter, Staphylococccus aureus, Enterococcus). As a result, it was revealed that various beta-lactamase genes have been widely distributed to Gram-negative rods represented by E. coli, and virulence factor PVL (Panton-Valentine leukocidin) associated with increased pathogenicity has been prevalent at relatively high rate among methicillin-resistant S. aureus (MRSA).

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  • 日本と中国における結核の時間的・空間的な流行動態に関する研究

    2016.4 - 2019.3

    文部科学省  科学研究費補助金（基盤研究(C)） 

    鷲見 紋子

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    Authorship：Principal investigator  Grant type：Competitive

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  • Study on prevalence and molecular epidemiological characteristics of novel community-acquired MRSA that emerged in Japan

    Grant number：26460804  2014.4 - 2018.3

    Japan Society for the Promotion of Science  Grants-in-Aid for Scientific Research  Grant-in-Aid for Scientific Research (C)

    Kobayashi Nobumichi, KAWAGUCHIYA Mitsuyo, AUNG Meijisoe, ITO Masahiko, SHINAGAWA Masaaki

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    Grant amount：\4940000 （ Direct Cost: \3800000 、 Indirect Cost：\1140000 ）

    Methicillin-resistant Staphylococcus aureus (MRSA) is drug-resistant bacteria known for a long time. Recently, two MRSA clones with novel genetic traits (①MRSA harboring SCCmec-IVl which is a novel genetic complex; ②Coagulase type-II MRSA having ACME which is a genetic complex related to attachment to human skin) have been reported. We investigated their prevalence in clinical isolates in Hokkaido, Japan. These MRSA ①, ② were detected in 3.5% and 5.1% of isolates from outpatients of community, and 3% and 0.9% of isolates from a university hospital, respectively. Genetic diversity was found in MRSA with ACME, and their spread in the community and hospitals was concerned.

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  • Molecular epidemiology and population dynamics of rotaviruses in Asia based on novel comprehensive whole genomic analysis method

    Grant number：25305022  2013.4 - 2017.3

    Japan Society for the Promotion of Science  Grants-in-Aid for Scientific Research  Grant-in-Aid for Scientific Research (B)

    Nobumichi Kobayashi, AIDA Satoru, WANG Yuanhong, PAUL Shyamal

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    Grant amount：\17550000 （ Direct Cost: \13500000 、 Indirect Cost：\4050000 ）

    Epidemic dynamics for long periods of human rotaviruses in Asia was analyzed molecular epidemiologically based on whole genome (11 gene segments). In Wuhan, China, G3P[8] was the most prevalent genotype of rotaviruses over past 10 years, which was thereafter replaced by G9P[8]. Change of lineages was detected for most of their gene segments with the passage of time. In Bangladesh, two lineages of the most prevalent G2P[4] genotype in 2010 were replaced by a novel lineage after 3 years. These findings indicated that replacement of gene segments via reassortment and mutation occurred over time among rotaviruses with prevalent genotypes. It was suggested that genetic changes have been occurring constantly even among the same genotype of rotaviruses.

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  • 中国における結核およびインフルエンザの時間的・空間的な流行動態に関する研究

    2013.4 - 2016.3

    文部科学省  科学研究費補助金（基盤研究(C)） 

    鷲見 紋子

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    Authorship：Principal investigator  Grant type：Competitive

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  • Identification and molecular epidemiological analysis of emerging clones of community-acquired MRSA

    Grant number：23590746  2011 - 2013

    Japan Society for the Promotion of Science  Grants-in-Aid for Scientific Research  Grant-in-Aid for Scientific Research (C)

    KOBAYASHI Nobumichi, SUMI Ayako, URUSHIBARA Noriko, GHOSH Souvik

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    Grant amount：\5460000 （ Direct Cost: \4200000 、 Indirect Cost：\1260000 ）

    To investigate prevalence in Japan of community-acquired MRSA (CA-MRSA) which is concerned for its global spread, and their molecular epidemiological characteristics, we analyzed clinical isolates from the Sapporo Medical University Hospital (601 isolates, 2008-2010) and those from local hospitals/clinics in Hokkaido prefecture (outpatients, 422 isolates in 2011). As a result, SCCmec types IV and V, which are genetic markers of CA-MRSA, were detected in 4.3% and 17.1% in the isolates from the University Hospital and local hospitals/clinics, respectively. Among them, seven isolates were revealed to be USA300 clone which is dominant in the US (ST8, positive for PVL and ACME), and many ST5 MRSA having ACME were detected. These emerging CA-MRSA clones were confirmed to be distributed in Japan.

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  • Infection dynamics and molecular mechanisms of prevalence of new variant and emerging Rotaviruses prevailing in Asia

    Grant number：22406017  2010 - 2012

    Japan Society for the Promotion of Science  Grants-in-Aid for Scientific Research  Grant-in-Aid for Scientific Research (B)

    KOBAYASHI Nobumichi, ISHINO Masaho, SUMI Ayako, URUSHIBARA Noriko, GHOSH Souvik

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    Grant amount：\19500000 （ Direct Cost: \15000000 、 Indirect Cost：\4500000 ）

    To elucidate genetic characteristics of new variants and emerging types of rotavirus that spread to mainly in Asian countries, whole genomic sequence analysis and phylogenetic analysis were conducted. In China and Bangladesh, the predominant genotypes were G1P[8]/G3P[8], G2P[4], respectively, among which reassortant viruses containing gene segments derived from animal rotavirus were detected. Rotaviruses with P[8]b, a new variant of P[8]-VP4 genotype, were detected in China, Bangladesh, and Myanmar, and mostly associated with globally emerging type G9. Whole genomic analysis of various rotaviruses strains with emerging genotypes from Asia and other regions (genotypes G1P[6], G2P[6], G3P[2]、G3P[6], G3P[9], G4P[10], G6P[9], G8P[1], G9P[19]) revealed that these strains could be classified into 1)reassortant between different human rotavirus genogroups, 2)reassortant between human and animal rotaviruses, and 3) animal rotaviruses that directly transmitted to humans. These findings indicated that reassortment and interspecies transmission may be the main causing mechanisms of new variants and emergingtypes of human rotaviruses.

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  • インフルエンザの時間的および空間的な流行動態に関する研究

    2008.4 - 2011.3

    文部科学省  科学研究費補助金（基盤研究(C)） 

    鷲見 紋子

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    Authorship：Principal investigator  Grant type：Competitive

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  • Study on prevalence of PVL-positive Staphylococcus aureus and MRSA with the use of novel molecular epidemiologic methods

    Grant number：20590608  2008 - 2010

    Japan Society for the Promotion of Science  Grants-in-Aid for Scientific Research  Grant-in-Aid for Scientific Research (C)

    KOBAYASHI Nobumichi, ISHINO Masaho, SUMI Ayako, NAGASHIMA Mshigeo, URUSHIBARA Noriko

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    Grant amount：\4810000 （ Direct Cost: \3700000 、 Indirect Cost：\1110000 ）

    Prevalence and molecular epidemiologic characteristics of methicillin-resistant S.aureus (MRSA) were analyzed for numerous Staphylococcus aureus isolates derived from outpatients in hospitals in Hokkaido. As a result, several MRSA strains (genotypes ST6, ST59) which harbor the Panton-Valentine Leukocidin (PVL) gene typical to CA-MRSA, and the genetic element ACME unique to USA300 CA-MRSA clone predominating in USA,were identified, suggesting the wide distribution of these MRSA to the community.

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  • Study of characteristics and prevalence of novel species rotavirus detected in Asia

    Grant number：18406018  2006 - 2008

    Japan Society for the Promotion of Science  Grants-in-Aid for Scientific Research  Grant-in-Aid for Scientific Research (B)

    KOBAYASHI Nobumichi, ISHINO Masaho, SUMI Ayako, NAGASHIMA Shigeo, MISE Keiji, TANIGUCHI Koki, T.N Naik, T Krishnan, M Chawla-sarkar, S.K Paul, M.M Alam, T.S Aung, Y-H Wang, X Zhou

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    Grant amount：\15750000 （ Direct Cost: \13500000 、 Indirect Cost：\2250000 ）

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  • Identification and prevalence of antiseptip resistance genes in enterococci

    Grant number：17590521  2005 - 2007

    Japan Society for the Promotion of Science  Grants-in-Aid for Scientific Research  Grant-in-Aid for Scientific Research (C)

    KOBAYAHI Nobumichi, ISHINO Masaho, SUMI Ayako, NAGASHIMA Shigeo

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    Grant amount：\3900000 （ Direct Cost: \3600000 、 Indirect Cost：\300000 ）

    The purpose of this study is to identify antiseptic resistance genes in enterococci and clarify their epidemiological characteristics. We analyzed a total of about 1100 clinical isolates from the Sapporo Medical University Hospital obtained from 1997 to 2007, and 117 strains isolated outside this hospital. These strains were analyzed for presence of genes encoding multidrug efflux pumps, EfrA, EfrB, EmeA, and QacH, by PCR. The emeA was detected in all the E.faecalis, and efrA/efrB was found in all the isolates of E.faecalis and E.faecium. However, qacH gene was not detected in any enterococcal species. Through genetic analysis of E.faecium, at least four different kinds of genes encoding multidrug-efflux proteins were detected. Furthermore, in the whole gonome of E.faecium deposited in GenBank database, at least 80 genes encoding ABC transporters were found to be described. Enterococcal ABC transporters EfrA and EfrB are considered to belong to a same group as T LmrA of lactococcus, but different from MsrC which mediates efflux of macrolides. Further analysis on influence of sorts and numbers of drug-efflux genes on expression of antiseptic resistance in enterococci was considered to be needed in the future.

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  • Study on actual status of adult rotavirus infections in Southern Asia and Southeastern Asia

    Grant number：15406028  2003 - 2005

    Japan Society for the Promotion of Science  Grants-in-Aid for Scientific Research  Grant-in-Aid for Scientific Research (B)

    KOBAYASHI Nobumichi, KOJIMA Kazunobu, ISHINO Masaho, TANIGUCHI Koki, MISE Keiji, SUMI Ayako

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    Grant amount：\11400000 （ Direct Cost: \11400000 ）

    The purpose of this study is to characterize rotaviruses which cause diarrheal diseases in adults in Southern Asian and Southeast Asian regions. This study was performed in collaboration with India, Bangladesh, Thailand, and China. Stool specimens were collected from diarrheal patients in a period between 2003 and 2005. While detection rate of group A rotavirus in children was 25-35%, detection rate in adult ranged from approx. 1% to 10%. In the study in China, most rotavirus strains from children and adults showed identical antigenic types. Group B rotavirus was detected in adult stool specimens in Bangladesh (14 specimens) and China (2 specimens). In India, group B rotavirus was detected by RT-PCR in about 20% of diarrheal stool specimens from children. Phylogenetic analysis of the group B rotaviruses from individual countries indicated that the viruses from India and Bangladesh were genetically closely related but distinct from Chinese viruses. The Indian-Bangladeshi group B rotaviruses and Chinese viruses were suggested to be diverged from a common ancestral virus approximately 60-70 years ago based on estimation of mutation rate calculated for Chinese virus strains. In Bangladesh, an unusual rotavirus strain was detected. This virus was genetically different from the known group A, B, and C rotaviruses, and suggested to represent a novel species (group) of rotavirus. As a study on special characteristic of group B rotavirus, i.e., causing diarrhea primarily in adults, nonstructural protein NSP4 was studied for its sequence diversity and presence of enterotoxin activity which is known as one of the mechanisms causing diarrhea in animals. As a result, group B rotavirus NSP4 exhibited high degree of sequence divergence from group A rotavirus NSP4, however, it was demonstrated that sequences near the C-terminal region possess enterotoxin activity in suckling mice. These findings suggested that group B rotavirus may have similar mechanisms for causing diarrhea in human to group A rotavirus.

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  • 感染症サーベイランスデータの時系列解析方法の開発

    1998.4 - 2001.3

    文部省  科学研究費補助金（特別研究員奨励費・PD） 

    鷲見 紋子

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    Authorship：Principal investigator  Grant type：Competitive

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  • 医学・生物学分野のカオス時系列の予測解析

    1996.4 - 1998.3

    文部省  科学研究費補助金（特別研究員奨励費・DC） 

    鷲見 紋子

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    Authorship：Principal investigator  Grant type：Competitive

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  • 感染症およびその病原体の発生変動の時間的変動構造に関する研究、DNA配列のフラクタル性に関する研究

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    Grant type：Competitive

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