SUMI Aako

写真a

Affiliation

Medical Development Center Dean, Department of Liberal Arts and Sciences, Physics

Job title

Professor

Education 【 display / non-display

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    1998

    Hokkaido University  

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    1994

    Kobe University  

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    1991

    Hokkaido University  

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    Kobe University   Graduate School of Science   地球科学科非線形科学講座  

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    Hokkaido University   School of Science   地球物理学科  

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Degree 【 display / non-display

  • Ph.D

Professional Memberships 【 display / non-display

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    日本ウイルス学会

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    日本衛生学会

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    日本臨床ウイルス学会

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    日本物理学会

Research Areas 【 display / non-display

  • Natural sciences   Bio-, chemical, and soft-matter physics  

Affiliation 【 display / non-display

  • Sapporo Medical University   医療人育成センター 教養教育研究部門   教授  

 

Research Interests 【 display / non-display

  • Mathematical biology Epidemiology of infectious diseases Nonlinear science Time series analysis

Papers 【 display / non-display

  • Time series analysis of daily reported number of new positive cases of COVID-19 in Japan from January 2020 to February 2023

    Ayako Sumi

    PLoS ONE    2023.09  [Refereed]

    Authorship:   Lead author  , Corresponding author

  • Associations between Meteorological Factors and Reported Mumps Cases from 1999 to 2020 in Japan

    Keiji Mise, Ayako Sumi, Shintaro Takatsuka, Shin-ichi Toyoda

    Epidemiologia ( MDPI AG )  2 ( 2 ) 162 - 178  2021.04  [Refereed]

    Authorship:   Corresponding author

     View Summary

    The present study investigated associations between epidemiological mumps patterns and meteorological factors in Japan. We used mumps surveillance data and meteorological data from all 47 prefectures of Japan from 1999 to 2020. A time-series analysis incorporating spectral analysis and the least-squares method was adopted. In all power spectral densities for the 47 prefectures, spectral lines were observed at frequency positions corresponding to 1-year and 6-month cycles. Optimum least-squares fitting (LSF) curves calculated with the 1-year and 6-month cycles explained the underlying variation in the mumps data. The LSF curves reproduced bimodal and unimodal cycles that are clearly observed in northern and southern Japan, respectively. In investigating factors associated with the seasonality of mumps epidemics, we defined the contribution ratios of a 1-year cycle (Q1) and 6-month cycle (Q2) as the contributions of amplitudes of 1-year and 6-month cycles, respectively, to the entire amplitude of the time series data. Q1 and Q2 were significantly correlated with annual mean temperature. The vaccine coverage rate of a measles–mumps–rubella vaccine might not have affected the 1-year and 6-month modes of the time series data. The results of the study suggest an association between mean temperature and mumps epidemics in Japan.

    DOI

  • Clonal lineages and antimicrobial resistance of nonencapsulated Streptococcus pneumoniae in the post-pneumococcal conjugate vaccine era in Japan.

    Mitsuyo Kawaguchiya, Noriko Urushibara, Meiji Soe Aung, Kenji Kudo, Masahiko Ito, Ayako Sumi, Nobumichi Kobayashi

    International journal of infectious diseases : IJID : official publication of the International Society for Infectious Diseases   105   695 - 701  2021.03  [International journal]

     View Summary

    OBJECTIVES: The emergence and spread of nonencapsulated Streptococcus pneumoniae (NESp) is a public health concern in the post-pneumococcal conjugate vaccine era. We analyzed the prevalence, molecular characteristics, and antimicrobial resistance of NESp responsible for non-invasive infections in northern Japan. METHODS: Among 4463 S. pneumoniae isolates collected from non-invasive infection cases during four study periods between January 2011 and January 2019, NESp isolates were identified using molecular and phenotypical methods. NESp isolates were analyzed for antimicrobial susceptibility, genotype, and virulence-associated genes. RESULTS: A total of 71 NESp isolates were identified (1.6% of all the clinical isolates) and assigned to the null capsule clade (NCC)1 (pspK+) (94.4%) or NCC2 (aliC+/aliD+) (5.6%). Five dominant sequence types (STs) were ST7502 (23.9%), ST4845 (19.7%), ST16214 (11.3%), ST11379 (9.9%), and ST7786 (7.0%). These dominant STs and all seven novel STs were related to the sporadic NESp lineage ST1106 or PMEN clone Denmark14-ST230. High non-susceptibility rates of NESp were observed for trimethoprim-sulfamethoxazole, erythromycin, and tetracycline (>92.9%), and multidrug resistance was observed in 88.7% of the NESp isolates, including all the ST7502, ST4845, and ST11379 isolates. CONCLUSIONS: The present study revealed that the dominant clonal groups of NESp were associated with a high prevalence of non-susceptibility to antimicrobials in northern Japan.

    DOI PubMed

  • Clonal Diversity and Genetic Characteristics of Methicillin-Resistant Staphylococcus aureus Isolates from a Tertiary Care Hospital in Japan.

    Meiji Soe Aung, Noriko Urushibara, Mitsuyo Kawaguchiya, Ayako Sumi, Masaaki Shinagawa, Satoshi Takahashi, Nobumichi Kobayashi

    Microbial drug resistance (Larchmont, N.Y.)   25 ( 8 ) 1164 - 1175  2019.10  [International journal]

     View Summary

    Molecular epidemiological characteristics were investigated for 1,041 isolates of methicillin-resistant Staphylococcus aureus (MRSA) collected in a tertiary care hospital in northern Japan for a 4-year period (2011-2014). Genotypes (staphylococcal cassette chromosome mec [SCCmec], sequence type, spa, coa, etc.) and the presence of drug resistance/virulence factor genes in the isolates were analyzed by multiplex/uniplex PCR, and PCR-direct sequencing as needed. Among these MRSA, predominant SCCmec type was IIa (87.2%), followed by IV (10.1%) and V (1.2%). The SCCmec IIa-MRSA belonged to coagulase genotype (coa) IIa and ST5/ST764, which are known as major health care-associated-MRSA (HA-MRSA) in Japan (New York/Japan clone) and its variant. Panton-Valentine leucocidine (PVL) genes were detected in only five isolates (0.5%) with genotypes ST8-SCCmec IVa/spa-t008/coa-IIIa (USA300 clone), ST6-SCCmec IVb, and ST59-SCCmec V (Taiwanese clone). Arginine catabolic mobile element (ACME) type I and II' were identified in three and five isolates of ST8-SCCmec IVa and ST764-SCCmec IIa MRSA, respectively. PVL-/ACME- isolates were classified into various STs/clonal complexes (CCs), with CC1, CC5, CC8, CC89, and CC121 being common. It was notable that SCCmec IVl was the most common among SCCmec IV subtypes, and was carried by almost half of coa-IIIa isolates (47%, 34/72) without PVL genes, which represented the novel ST8 MRSA clone spreading in Japan (i.e., "ST8/CA-MRSA/J"). Uncommon MRSA clones in Japan, ST72-SCCmec IV (South Korean clone), ST398 livestock-associated clone, and ST20 bovine-associated MRSA, were identified. Furthermore, we isolated PVL-negative ST8-SCCmec I/coa-IIIa and ST81-SCCmec V/coa-VIIa MRSA, which were considered presumptive novel clones. The present study revealed the genetic diversity of HA-MRSA, including potentially emerging clones of putative different origins.

    DOI PubMed

  • Molecular Epidemiological Characterization of Staphylococcus argenteus Clinical Isolates in Japan: Identification of Three Clones (ST1223, ST2198, and ST2550) and a Novel Staphylocoagulase Genotype XV.

    Meiji Soe Aung, Noriko Urushibara, Mitsuyo Kawaguchiya, Ayako Sumi, Seika Takahashi, Miyo Ike, Masahiko Ito, Satoshi Habadera, Nobumichi Kobayashi

    Microorganisms   7 ( 10 )  2019.09  [International journal]

     View Summary

    Staphylococcus argenteus, a novel emerging species within Staphylococcus aureus complex (SAC), has been increasingly reported worldwide. In this study, prevalence of S. argenteus among human clinical isolates, and their clonal diversity and genetic characteristics of virulence factors were investigated in Hokkaido, the northern main island of Japan. During a four-month period starting from March 2019, twenty-four S. argenteus and 4330 S. aureus isolates were recovered from clinical specimens (the ratio of S. argenteus to S. aureus :0.0055). Half of S. argenteus isolates (n = 12) belonged to MLST sequence type (ST) 2250 and its single-locus variant, with staphylocoagulase genotype (coa-) XId, while the remaining isolates were assigned to ST2198/coa-XIV (n = 6), and ST1223 with a novel coa-XV identified in this study (n = 6). All the isolates were mecA-negative, and susceptible to all the antimicrobials tested, except for an ST2198 isolate with blaZ and an ST2250 isolate with tet(L) showing resistance to ampicillin and tetracyclines, respectively. Common virulence factors in the S. argenteus isolates were staphylococcal enterotoxin (-like) genes sey, selz, sel26, and sel27 in ST2250, selx in ST2198, and enterotoxin gene cluster (egc-1: seg-sei-sem-sen-seo) in ST1223 isolates, in addition to hemolysin genes (hla, hlb, and hld) distributed universally. Elastin binding protein gene (ebpS) and MSCRAMM family adhesin SdrE gene (sdrE) detected in all the isolates showed high sequence identity among them (> 97%), while relatively lower identity to those of S. aureus (78-92%). Phylogenetically, ebpS, sdrE, selx, sey, selw, sel26, and sel27 of S. argenteus formed clusters distinct from those of S. aureus, unlike sec, selz, tst-1, and staphylokinase gene (sak). The present study revealed the prevalence of S. argenteus among clinical isolates, and presence of three distinct S. argenteus clones (ST2250; ST2198 and ST1223) harboring different virulence factors in northern Japan. ST2198 S. argenteus, a minor clone (strain BN75-like) that had been rarely reported, was first identified in Japan as human isolates.

    DOI PubMed

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Books and Other Publications 【 display / non-display

  • 時間感染症学

    鷲見, 紋子, 大友, 詔雄, 小林, 宣道

    北海道大学出版会  2020.02 ISBN: 9784832982338

Misc 【 display / non-display

  • 有酸素運動の運動強度の新たな指標に関する研究 ランニングの場合

    鷲見 紋子

    デサントスポーツ科学 ( (公財)石本記念デサントスポーツ科学振興財団 )  41   252 - 259  2020.09

     View Summary

    本研究の目的は,有酸素運動に関する運動強度の新たな指標を提起することを目指して,心拍変動の時間的変動構造,すなわち心拍変動の周期構造とゆらぎの性質を詳細に調べることである.このために,これまで広く用いられてきたスペクトル解析法を土台にした時系列解析法を用いて,心拍変動の時間的変動構造を調べた.研究対象としては,今日とりわけ競技人口の多いランニングをとりあげ,ランニング中の被験者のR-R間隔・心拍数を測定し,スペクトル解析を実行した.その結果,ランニング中の心拍変動の極低周波数領域(VLF)領域(0.003-0.04Hz)と超低周波数領域(ULF)領域(0.003Hz未満)において,明瞭な周期構造が観測された.最近VLF成分およびULF成分が疾病予後あるいは生命予後の指標として注目されているが,これらの機序については未だほとんど明らかにされていない.今回の解析結果が,VLF成分およびULF成分の機序を明らかにする有益な情報を提供することが期待される.(著者抄録)

  • 海外情報 なぜ、フィンランドでは麻疹の排除が、先進国で最初に可能となったのか?

    鷲見 紋子, 久末 智実, Salvola Helmi

    北海道公衆衛生学雑誌 ( 北海道公衆衛生学会 )  33 ( 2 ) 103 - 106  2020.03

     View Summary

    フィンランドでは、1994年に麻疹の排除が報告され、これは先進国の中で一番早い。麻疹を排除するためには、ワクチンを2回接種すること、そしてその2回の接種率をそれぞれ95%以上にすることが必要であると考えられており、フィンランドではこの2点を達成している。本稿ではフィンランドで高い予防接種率が実現されている背景をハメーンリンナ市の保健センターの見学を基に報告する。(著者抄録)

  • 【開発途上国における感染症研究支援】中国・インド・フィリピン・北欧との感染症発生動向に関する共同研究

    鷲見 紋子, 小林 宣道

    日本衛生学雑誌 ( (一社)日本衛生学会 )  72 ( 2 ) 112 - 122  2017.05  [Refereed]

    Article, review, commentary, editorial, etc. (scientific journal)  

    DOI

  • Molecular epidemiologic analysis of group A rotaviruses from adults and children in Wuhan city, China

    KOBAYASHI Nobumichi

    日本衞生學雜誌   62 ( 2 ) 592 - 592  2007.03

    CiNii

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Research Projects 【 display / non-display

  • 新型コロナウイルス感染症の時間的および空間的な流行動態に関する研究

    基盤研究(C)

    Project Year :

    2022.04
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    2025.03
     

    鷲見 紋子, 小山 雅之

  • 日本・中国・北欧における多剤耐性結核の時間的および空間的な流行動態に関する研究

    Project Year :

    2019.04
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    2022.03
     

    鷲見 紋子

    Authorship: Principal investigator

  • 時間感染症学

    Project Year :

    2019.04
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    2020.03
     

    鷲見 紋子

    Authorship: Principal investigator

  • 有酸素運動の運動強度の新たな指標に関する研究-ランニングの場合-

    Project Year :

    2019.04
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    2020.03
     

    鷲見 紋子

    Authorship: Principal investigator

  • Analysis of present status and comprehensive molecular epidemiology of emerging drug-resistant bacteria in developing regions of Asia and Caribbean province

    Grant-in-Aid for Scientific Research (B)

    Project Year :

    2017.04
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    2020.03
     

    Kobayashi Nobumichi

     View Summary

    In three countries in Asia and Caribbean regions (Bangladesh, Myanmar, and Cuba) where information on antimicrobial resistance (AMR) is insufficient, resistance rates to various antimicrobials, prevalence of genes associated with AMR and virulence, genetic characteristics of drug-resistant isolates were analyzed for major pathogenic bacterial species (Escherichia coli, Klebsiella pneumoniae, Acinetobacter, Staphylococccus aureus, Enterococcus). As a result, it was revealed that various beta-lactamase genes have been widely distributed to Gram-negative rods represented by E. coli, and virulence factor PVL (Panton-Valentine leukocidin) associated with increased pathogenicity has been prevalent at relatively high rate among methicillin-resistant S. aureus (MRSA).

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