Education 【 display / non-display 】

Education 【 display / non-display 】

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  Kobe University   Graduate School of Science   M.S.  

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  修了

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  Hokkaido University   Faculty of Science (Geophysics)   B.S.  

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  卒業

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  Hokkaido University   School of Medicine   Ph.D.  

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  修了

Degree 【 display / non-display 】

Degree 【 display / non-display 】

• Hokkaido University   Ph.D

Research Experience 【 display / non-display 】

Research Experience 【 display / non-display 】

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  札幌医科大学 医学部 衛生学講座 助手  

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  日本学術振興会特別研究員（PD）  

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  デンマーク国立オーデンセ大学  

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  日本学術振興会特別研究員（DC）  

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  札幌医科大学 医学部 衛生学講座 講師  

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Professional Memberships 【 display / non-display 】

Professional Memberships 【 display / non-display 】

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  日本数理生物学会

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  日本医学教育学会

Research Areas 【 display / non-display 】

Research Areas 【 display / non-display 】

• Natural sciences   Bio-, chemical, and soft-matter physics  

Affiliation 【 display / non-display 】

Affiliation 【 display / non-display 】

• Sapporo Medical University   Division of Physics, Department of Liberal Arts and Sciences, Center for Medical Education   Professor  

Research Interests 【 display / non-display 】

Research Interests 【 display / non-display 】

• Mathematical biology Epidemiology of infectious diseases Nonlinear science Time series analysis

Papers 【 display / non-display 】

Papers 【 display / non-display 】

• Spectral study of COVID-19 pandemic in Japan: the dependence of spectral gradient on the population size of the community (in press)

  Ayako Sumi, Masayuki Koyama, Manato Katagiri, Norio Ohtomo

  PLoS ONE    2024.11  [Refereed]

  Authorship：   Lead author  , Corresponding author

• Time series analysis of daily reported number of new positive cases of COVID-19 in Japan from January 2020 to February 2023

  Ayako Sumi

  PLoS ONE    2023.09  [Refereed]

  Authorship：   Lead author  , Corresponding author

• Associations between Meteorological Factors and Reported Mumps Cases from 1999 to 2020 in Japan

  Keiji Mise, Ayako Sumi, Shintaro Takatsuka, Shin-ichi Toyoda

  Epidemiologia ( MDPI AG )  2 ( 2 ) 162 - 178  2021.04  [Refereed]

  Authorship：   Corresponding author

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  The present study investigated associations between epidemiological mumps patterns and meteorological factors in Japan. We used mumps surveillance data and meteorological data from all 47 prefectures of Japan from 1999 to 2020. A time-series analysis incorporating spectral analysis and the least-squares method was adopted. In all power spectral densities for the 47 prefectures, spectral lines were observed at frequency positions corresponding to 1-year and 6-month cycles. Optimum least-squares fitting (LSF) curves calculated with the 1-year and 6-month cycles explained the underlying variation in the mumps data. The LSF curves reproduced bimodal and unimodal cycles that are clearly observed in northern and southern Japan, respectively. In investigating factors associated with the seasonality of mumps epidemics, we defined the contribution ratios of a 1-year cycle (Q1) and 6-month cycle (Q2) as the contributions of amplitudes of 1-year and 6-month cycles, respectively, to the entire amplitude of the time series data. Q1 and Q2 were significantly correlated with annual mean temperature. The vaccine coverage rate of a measles–mumps–rubella vaccine might not have affected the 1-year and 6-month modes of the time series data. The results of the study suggest an association between mean temperature and mumps epidemics in Japan.

  DOI

• Clonal lineages and antimicrobial resistance of nonencapsulated Streptococcus pneumoniae in the post-pneumococcal conjugate vaccine era in Japan.

  Mitsuyo Kawaguchiya, Noriko Urushibara, Meiji Soe Aung, Kenji Kudo, Masahiko Ito, Ayako Sumi, Nobumichi Kobayashi

  International journal of infectious diseases : IJID : official publication of the International Society for Infectious Diseases   105   695 - 701  2021.03  [International journal]

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  OBJECTIVES: The emergence and spread of nonencapsulated Streptococcus pneumoniae (NESp) is a public health concern in the post-pneumococcal conjugate vaccine era. We analyzed the prevalence, molecular characteristics, and antimicrobial resistance of NESp responsible for non-invasive infections in northern Japan. METHODS: Among 4463 S. pneumoniae isolates collected from non-invasive infection cases during four study periods between January 2011 and January 2019, NESp isolates were identified using molecular and phenotypical methods. NESp isolates were analyzed for antimicrobial susceptibility, genotype, and virulence-associated genes. RESULTS: A total of 71 NESp isolates were identified (1.6% of all the clinical isolates) and assigned to the null capsule clade (NCC)1 (pspK+) (94.4%) or NCC2 (aliC+/aliD+) (5.6%). Five dominant sequence types (STs) were ST7502 (23.9%), ST4845 (19.7%), ST16214 (11.3%), ST11379 (9.9%), and ST7786 (7.0%). These dominant STs and all seven novel STs were related to the sporadic NESp lineage ST1106 or PMEN clone Denmark14-ST230. High non-susceptibility rates of NESp were observed for trimethoprim-sulfamethoxazole, erythromycin, and tetracycline (>92.9%), and multidrug resistance was observed in 88.7% of the NESp isolates, including all the ST7502, ST4845, and ST11379 isolates. CONCLUSIONS: The present study revealed that the dominant clonal groups of NESp were associated with a high prevalence of non-susceptibility to antimicrobials in northern Japan.

  DOI PubMed

• New Development of Disaster-Related and Tropical Infectious Diseases Control

  Gaowa Bai, Toshiro Niki, Haruhisa Kikuchi, Ayako Sumi, Nobuyuki Kobayashi, Takahiro Haruyama, Jing Zhang, Haorile Chagan-Yasutan, Toshio Hattori

  Reports — Medical Cases, Images, and Videos ( MDPI AG )  3 ( 1 ) 5 - 5  2020.03  [Refereed]

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  As described in Japanese essay (Hojoki), written around 1200, various disasters such as big fires, earthquakes, and famines have occurred in Japan. Asian countries have been suffering from the disasters; furthermore, natural disasters are increasing due to global warming. Because tropical-infectious diseases are often disaster-related infectious diseases (DRIDs), the strategies against the former kind of disease could be applicable to DRIDs. Meteorological analysis of the occurrence of DRIDs using a method of time series analysis is important. In situations of disasters, it is desirable if you can identify the pathogen and identify disease severity simultaneously. A dipstick DNA chromatography assay termed as Single-Tag Hybridization—Printed Array Strip (STH—PAS) system was developed based on the DNA sequences of various mosquito-borne diseases. The plasma levels of matricellular proteins including galectin-9 (Gal-9) and osteopontin (OPN) were found to reflect the disease severities in the dengue virus and other DIRDs. Because both proteins have been reported to be immune-check molecules, their inhibition might enhance the immune system against pathogens. We found that brefelamide derivatives could inhibit OPN and other inflammatory molecules synthesis. Very recently, different derivatives were found to inhibit PD-L1 transcription. Applications of these agents should be considered as multi-step strategies against DRIDs.

  DOI

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Books and Other Publications 【 display / non-display 】

Books and Other Publications 【 display / non-display 】

• 時間感染症学

  鷲見, 紋子, 大友, 詔雄, 小林, 宣道

  北海道大学出版会  2020.02 ISBN: 9784832982338

Misc 【 display / non-display 】

Misc 【 display / non-display 】

• 有酸素運動の運動強度の新たな指標に関する研究 ランニングの場合

  鷲見 紋子

  デサントスポーツ科学 ( (公財)石本記念デサントスポーツ科学振興財団 )  41   252 - 259  2020.09

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  本研究の目的は,有酸素運動に関する運動強度の新たな指標を提起することを目指して,心拍変動の時間的変動構造,すなわち心拍変動の周期構造とゆらぎの性質を詳細に調べることである.このために,これまで広く用いられてきたスペクトル解析法を土台にした時系列解析法を用いて,心拍変動の時間的変動構造を調べた.研究対象としては,今日とりわけ競技人口の多いランニングをとりあげ,ランニング中の被験者のR-R間隔・心拍数を測定し,スペクトル解析を実行した.その結果,ランニング中の心拍変動の極低周波数領域(VLF)領域(0.003-0.04Hz)と超低周波数領域(ULF)領域(0.003Hz未満)において,明瞭な周期構造が観測された.最近VLF成分およびULF成分が疾病予後あるいは生命予後の指標として注目されているが,これらの機序については未だほとんど明らかにされていない.今回の解析結果が,VLF成分およびULF成分の機序を明らかにする有益な情報を提供することが期待される.(著者抄録)

• 海外情報 なぜ、フィンランドでは麻疹の排除が、先進国で最初に可能となったのか?

  鷲見 紋子, 久末 智実, Salvola Helmi

  北海道公衆衛生学雑誌 ( 北海道公衆衛生学会 )  33 ( 2 ) 103 - 106  2020.03

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  フィンランドでは、1994年に麻疹の排除が報告され、これは先進国の中で一番早い。麻疹を排除するためには、ワクチンを2回接種すること、そしてその2回の接種率をそれぞれ95%以上にすることが必要であると考えられており、フィンランドではこの2点を達成している。本稿ではフィンランドで高い予防接種率が実現されている背景をハメーンリンナ市の保健センターの見学を基に報告する。(著者抄録)

• 【開発途上国における感染症研究支援】中国・インド・フィリピン・北欧との感染症発生動向に関する共同研究

  鷲見 紋子, 小林 宣道

  日本衛生学雑誌 ( (一社)日本衛生学会 )  72 ( 2 ) 112 - 122  2017.05  [Refereed]

  Article, review, commentary, editorial, etc. (scientific journal)  

  DOI

• Collaborative Research with Chinese, Indian, Filipino and North European Research Organizations on Infectious Disease Epidemics

  Ayako Sumi, Nobumichi Kobayashi

  Nihon eiseigaku zasshi. Japanese journal of hygiene   72 ( 2 ) 112 - 122  2017

  Book review, literature introduction, etc.  

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  In this report, we present a short review of applications of time series analysis, which consists of spectral analysis based on the maximum entropy method in the frequency domain and the least squares method in the time domain, to the incidence data of infectious diseases. This report consists of three parts. First, we present our results obtained by collaborative research on infectious disease epidemics with Chinese, Indian, Filipino and North European research organizations. Second, we present the results obtained with the Japanese infectious disease surveillance data and the time series numerically generated from a mathematical model, called the susceptible/exposed/infectious/recovered (SEIR) model. Third, we present an application of the time series analysis to pathologic tissues to examine the usefulness of time series analysis for investigating the spatial pattern of pathologic tissue. It is anticipated that time series analysis will become a useful tool for investigating not only infectious disease surveillance data but also immunological and genetic tests.

  DOI PubMed

• Molecular epidemiologic analysis of group A rotaviruses from adults and children in Wuhan city, China

  KOBAYASHI Nobumichi

  日本衞生學雜誌   62 ( 2 ) 592 - 592  2007.03

  CiNii

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Research Projects 【 display / non-display 】

Research Projects 【 display / non-display 】

• 新型コロナウイルス感染症の時間的および空間的な流行動態に関する研究

  基盤研究(C)

  Project Year :

  2022.04

  -

  2025.03

   

  鷲見 紋子, 小山 雅之

• 日本・中国・北欧における多剤耐性結核の時間的および空間的な流行動態に関する研究

  Project Year :

  2019.04

  -

  2022.03

   

  鷲見 紋子

  Authorship： Principal investigator

• 時間感染症学

  Project Year :

  2019.04

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  2020.03

   

  鷲見 紋子

  Authorship： Principal investigator

• 有酸素運動の運動強度の新たな指標に関する研究－ランニングの場合－

  Project Year :

  2019.04

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  2020.03

   

  鷲見 紋子

  Authorship： Principal investigator

• Analysis of present status and comprehensive molecular epidemiology of emerging drug-resistant bacteria in developing regions of Asia and Caribbean province

  Grant-in-Aid for Scientific Research (B)

  Project Year :

  2017.04

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  2020.03

   

  Kobayashi Nobumichi

  　View Summary

  In three countries in Asia and Caribbean regions (Bangladesh, Myanmar, and Cuba) where information on antimicrobial resistance (AMR) is insufficient, resistance rates to various antimicrobials, prevalence of genes associated with AMR and virulence, genetic characteristics of drug-resistant isolates were analyzed for major pathogenic bacterial species (Escherichia coli, Klebsiella pneumoniae, Acinetobacter, Staphylococccus aureus, Enterococcus). As a result, it was revealed that various beta-lactamase genes have been widely distributed to Gram-negative rods represented by E. coli, and virulence factor PVL (Panton-Valentine leukocidin) associated with increased pathogenicity has been prevalent at relatively high rate among methicillin-resistant S. aureus (MRSA).

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