心筋細胞のネクロプトーシスにおけるミトコンドリア動態の影響(Impact of Mitochondrial Dynamics on Necroptosis in Cardiomyocytes)

戸田 悠貴, 矢野 俊之, 久野 篤史, 丹野 雅也, 神津 英至, 佐藤 達也, 大和田 渉, 舘越 勇輝, 小川 俊史, 清水 将輝, 古橋 眞人

日本循環器学会学術集会抄録集   88回   PJ080 - 3   2024.3

Role of AMP deaminase in diabetic cardiomyopathy

Tetsuji Miura, Hidemichi Kouzu, Masaya Tanno, Yuki Tatekoshi, Atsushi Kuno

Molecular and Cellular Biochemistry   2024.2

Early Commencement and Long-Term Continuation of Tolvaptan Treatment Attenuate Functional Impairment of Renal Vasopressin V2 Receptors and Improve Clinical Outcomes in Patients with Heart Failure Reviewed

Takahiro Noto, Arata Osanami, Nobutaka Nagano, Nobuaki Kokubu, Hidemichi Kouzu, Masaya Tanno

International Heart Journal   64 ( 1 )   36 - 43   2023.3

Downregulation of BCKDH Activity and Uncoupling from AMP Deaminase Underlie Substrate Inflexibility in Type 2 Diabetic Hearts(タイトル和訳中)

小川 俊史, 神津 英至, 長南 新太, 清水 将輝, 戸田 悠貴, 大和田 渉, 佐藤 達也, 矢野 俊之, 久野 篤史, 丹野 雅也, 三浦 哲嗣, 古橋 眞人

日本循環器学会学術集会抄録集   87回   OJ03 - 2   2023.3

BCKDH活性のダウンレギュレーションとAMPデアミナーゼとのアンカップリングが2型糖尿病性心臓における基質柔軟性の欠如を引き起こす(Downregulation of BCKDH Activity and Uncoupling from AMP Deaminase Underlie Substrate Inflexibility in Type 2 Diabetic Hearts)

小川 俊史, 神津 英至, 長南 新太, 清水 将輝, 戸田 悠貴, 大和田 渉, 佐藤 達也, 矢野 俊之, 久野 篤史, 丹野 雅也, 三浦 哲嗣, 古橋 眞人

日本循環器学会学術集会抄録集   87回   OJ03 - 2   2023.3

Adenosine monophosphate deaminase in the endoplasmic reticulum-mitochondria interface promotes mitochondrial Ca2+ overload in type 2 diabetes rat hearts.

Arata Osanami, Tatsuya Sato, Yuki Toda, Masaki Shimizu, Atsushi Kuno, Hidemichi Kouzu, Toshiyuki Yano, Wataru Ohwada, Toshifumi Ogawa, Tetsuji Miura, Masaya Tanno

Journal of diabetes investigation   2023.2

Downregulation of extramitochondrial BCKDH and its uncoupling from AMP deaminase in type 2 diabetic OLETF rat hearts Reviewed International journal

Toshifumi Ogawa, Hidemichi Kouzu, Arata Osanami, Yuki Tatekoshi, Tatsuya Sato, Atsushi Kuno, Yugo Fujita, Shoya Ino, Masaki Shimizu, Yuki Toda, Wataru Ohwada, Toshiyuki Yano, Masaya Tanno, Takayuki Miki, Tetsuji Miura

Physiological Reports   11 ( 4 )   e15608   2023.2

Nuclear translocation of MLKL enhances necroptosis by a RIP1/RIP3-independent mechanism in H9c2 cardiomyoblasts. Reviewed

Shoya Ino, Toshiyuki Yano, Atsushi Kuno, Masaya Tanno, Hidemichi Kouzu, Tatsuya Sato, Tomohisa Yamashita, Wataru Ohwada, Arata Osanami, Toshifumi Ogawa, Yuki Toda, Masaki Shimizu, Tetsuji Miura

Journal of pharmacological sciences   151 ( 2 )   134 - 143   2023.2

Features and Outcomes of Histologically Proven Myocarditis With Fulminant Presentation Reviewed

Koshiro Kanaoka, Kenji Onoue, Satoshi Terasaki, Tomoya Nakano, Michikazu Nakai, Yoko Sumita, Kinta Hatakeyama, Fumio Terasaki, Rika Kawakami, Yoshitaka Iwanaga, Yoshihiro Miyamoto, Yoshihiko Saito, Satoshi Yuda, Masaya Tanno, Toru Takahashi, Hisashi Yokoshiki, Masahiro Toba, Toshihisa Anzai, Toshiyuki Nagai, Takuma Sato, Takashi Takenaka, Seiji Yamazaki, Yuki Katagiri, Toshiharu Takeuchi, Kazuya Sugitatsu, Shigeo Kakinoki, Tomoaki Matsumoto, Kazushi Urasawa, Michinao Tan, Ichizo Tsujino, Mitsunori Kamigaki, Hirofumi Tomita, Kenji Hanada, Motoi Kushibiki, Akihiro Nakamura, Yoshihiro Morino, Takahito Nasu, Satoshi Yasuda, Hideaki Suzuki, Kaoru Iwabuchi, Kanako Tsuji, Shigeto Namiuchi, Tatsuya Komaru, Masahiro Yagi, Shoko Uematsu, Toshiaki Takahashi, Satoru Takeda, Toru Nakanishi, Masafumi Watanabe, Masahiro Wanezaki, Motoyuki Matsui, Shigeo Sugawara, Yasuchika Takeishi, Masayoshi Oikawa, Nobuo Komatsu, Satoshi Suzuki, Hiroshi Okamoto, Noriyuki Takeyasu, Daiki Akiyama, Yutaka Eki, Tsunekazu Kakuta, Tomoyo Sugiyama, Tomomi Koizumi, Koji Ueno, Kazuomi Kario, Mizuri Taki, Yuri Matsumoto, Takanori Yasu, Osamu Nishioka, Shigeto Naito, Makoto Murata, Shoichi Tange, Katsumi Kaneko, Makoto Muto, Hiroshi Inagaki, Shuichi Hasegawa, Eizo Tachibana, Wataru Atsumi, Masahiro Suzuki, Toshihiro Muramatsu, Yoshihiro Yamada, Isao Taguchi, Yoshiaki Fukuda, Akihiro Matsui, Junji Kanda, Koji Hozawa, Akihiko Matsumura, Wataru Shimizu, Takeshi Yamamoto, Issei Komuro, Masaru Hatano, Takanori Ikeda, Shunsuke Kiuchi, Taishiro Chikamori, Yasuyoshi Takei, Kyoko Soejima, Toshinori Minamishima, Hiroyuki Tanaka, Shigeo Shimizu, Masashi Kasao, Tadayuki Kadohira, Tohru Minamino, Kazunori Shimada, Hiroshi Iwata, Yukihiko Momiyama, Takashi Ashikaga, Toshihiro Nozato, Yasumasa Fujiwara, Kenji Inoue, Tetsuo Sasano, Junji Matsuda, Yasuhiro Ishii, Yuichi Ono, Kengo Tanabe, Yu Horiuchi, Toshiro Shinke, Yusuke Kodama, Masao Moroi, Yoshiyuki Yazaki, Taisuke Mizumura, Hiroshi Ohta, Yoshihiro Akashi, Nozomi Kotoku, Yuji Ikari, Mitsunori Maruyama, Yasuhiro Sato, Koichi Tamura, Masaaki Konishi, Hiroshi Suzuki, Mio Ebato, Kazuki Fukui, Kazuhiko Yumoto, Takamasa Iwasawa, Takeshi Kashimura, Kazuyoshi Takahashi, Yoshinobu Okada, Bunji Kaku, Kazuo Usuda, Michiro Maruyama, Tomoki Kameyama, Toshinori Higashikata, Akihiko Hodatsu, Kazuo Osato, Yoji Nagata, Koji Maeno, Kazuo Satake, Takao Sawanobori, Noboru Watanabe, Koichiro Kuwahara, Hirohiko Motoki, Hiroshi Kitabayashi, Kyuhachi Otagiri, Tsunesuke Kono, Daisuke Yamagishi, Yoshikazu Yazaki, Toshiyuki Noda, Itsuro Morishima, Naoki Watanabe, Shinichiro Tanaka, Tomoya Onodera, Ryuzo Nawada, Akinori Watanabe, Masaki Matsunaga, Satoru Suwa, Hiroshi Sakamoto, Hiroki Sakamoto, Takeshi Aoyama, Norio Kanamori, Masahiro Muto, Yuichiro Maekawa, Hayato Ohtani, Yukio Ozaki, Kenshin Naruse, Kenji Takemoto, Haruo Kamiya, Takeshi Suzuki, Yasushi Tomita, Susumu Suzuki, Ryosuke Kametani, Hidekazu Aoyama, Hiroyuki Osanai, Ken Harada, Kenji Kada, Tomoaki Saeki, Koichi Kobayashi, Yasuhiro Ogawa, Akihiro Terasawa, Masanori Shinoda, Mitsutoshi Oguri, Kiyokazu Shimizu, Akinori Sawamura, Atsushi Sugiura, Kosuke Hattori, Shinji Mokuno, Kazuhisa Kondo, Kaoru Dohi, Keishi Moriwaki, Atsunobu Kasai, Tetsuya Nakakuki, Kazuaki Kaitani, Toshikazu Jinnai, Takashi Yamamoto, Hiroyuki Kurata, Atsuyuki Wada, Masaharu Akao, Yasuhiro Hamatani, Kazuya Ishibashi, Yoshiki Akakabe, Yasuhide Asaumi, Hideo Matama, Yasushi Sakata, Hidetaka Kioka, Hiroshi Takaishi, Yoshitaka Iwanaga, Toru Takase, Mitsuo Matsuda, Fumi Sato, Shinji Hasegawa, Kenichi Ishigami, Minoru Ichikawa, Takashi Takagi, Moriaki Inoko, Masaaki Hoshiga, Shuichi Fujita, Yoshihiro Takeda, Takahiko Kawarabayashi, Hideyuki Takaoka, Kenji Nakajima, Tadashi Yuguchi, Tatsuya Kawasaki, Yukinori Shinoda, Yukihito Sato, Masaharu Ishihara, Yuki Matsumoto, Hiroya Kawai, Tomofumi Takaya, Kouki Matsuo, Toshiaki Mano, Kenichi Hirata, Eriko Hisamatsu, Nobutaka Inoue, Koichi Tamita, Naoki Mukohara, Hisashi Shimoyama, Toru Miyajima, Toshihiro Tamura, Yodo Tamaki, Megumi Suzuki, Ryoji Yokota, Manabu Horii, Kazuo Yamanaka, Hiroyuki Kawata, Yukihiro Hashimoto, Yasuki Nakada, Hitoshi Nakagawa, Tomoya Ueda, Taku Nishida, Ayako Seno, Makoto Watanabe, Takashi Akasaka, Takashi Tanimoto, Mamoru Toyofuku, Kazuhiro Yamamoto, Yoshiharu Kinugasa, Masayuki Hirai, Hiroshi Nasu, Kinya Shirota, Tsuyoshi Oda, Takefumi Oka, Kazushige Kadota, Masanobu Ohya, Hiroshi Ito, Kazufumi Nakamura, Soichiro Ogura, Soichiro Fuke, Shiro Uemura, Hiromi Matsubara, Atsuyuki Watanabe, Nobuyuki Morishima, Yasuki Kihara, Takayuki Hidaka, Hironori Ueda, Yujiro Ono, Yuji Muraoka, Miyo Hatanari, Yoshinori Miyamoto, Keigo Dote, Masaya Kato, Masafumi Yano, Mamoru Mochizuki, Yasuhiro Ikeda, Hiroyuki Fujinaga, Shinobu Hosokawa, Masataka Sata, Koji Yamaguchi, Naoko Aki, Tetsuo Minamino, Yuichi Miyake, Yuichiro Takagi, Masayuki Doi, Yoshio Taketani, Hideki Okayama, Tatsuya Shigematsu, Akinori Higaki, Osamu Yamaguchi, Shinji Inaba, Shuntaro Ikeda, Kazuya Kawai, Hiroaki Kitaoka, Toru Kubo, Kenji Ando, Kaoru Inui, Yoshihiro Fukumoto, Kensuke Hori, Takehiro Homma, Tomohiro Kawasaki, Masahiro Mohri, Masaki Fujiwara, Hiroyuki Tsutsui, Tomomi Ide, Shin-Ichiro Miura, Takashi Kuwano, Hideki Shimomura, Toshiaki Kadokami, Masanao Taba, Katsuhiro Kondou, Toru Kubota, Daisuke Nagatomo, Yasushi Mukai, Ryuichi Matsukawa, Hideki Tashiro, Mitsuhiro Shimomura, Koji Maemura, Hiroaki Kawano, Koji Oku, Toshihiko Yamasa, Yoshihisa Kizaki, Tomohiro Sakamoto, Yudai Tamura, Teruhiko Ito, Kazuteru Fujimoto, Kenichi Tsujita, Seiji Takashio, Hirofumi Kurokawa, Naohiko Takahashi, Shotaro Saito, Masaya Arikawa, Yoshisato Shibata, Kensaku Nishihira, Toshihiro Tsuruda, Masahiro Sonoda, Nobuhiko Atsuchi, Mitsuru Ohishi, Koji Higuchi, Masaaki Miyata, Naoya Oketani, Yoshinori Akimoto, Tomohiro Asahi, Minoru Wake

Circulation   146 ( 19 )   1425 - 1433   2022.11

AMPデアミナーゼの役割 2型糖尿病合併心不全の新しい治療標的

丹野 雅也, 長南 新太, 小川 俊史, 神津 英至

BIO Clinica   37 ( 10 )   940 - 945   2022.9

今月の症例 脳梗塞発症を契機に診断されたLoeffler心内膜心筋炎を伴う好酸球性多発血管炎性肉芽腫症の1例

大和田 渉, 矢野 俊之, 赤澤 史子, 神津 英至, 續 太郎, 宮森 大輔, 西川 諒, 永野 伸卓, 小山 雅之, 村中 敦子, 丹野 雅也

日本内科学会雑誌   111 ( 8 )   1580 - 1586   2022.8

Enhanced nuclear localization of phosphorylated MLKL predicts adverse events in patients with dilated cardiomyopathy Reviewed

Yugo Fujita, Toshiyuki Yano, Hiromitsu Kanamori, Daigo Nagahara, Atsuko Muranaka, Hidemichi Kouzu, Atsushi Mochizuki, Masayuki Koyama, Nobutaka Nagano, Takefumi Fujito, Ryo Nishikawa, Naoyuki Kamiyama, Marenao Tanaka, Atsushi Kuno, Masaya Tanno, Tetsuji Miura

ESC Heart Failure   2022.7

Insulin Resistance ― Beginning of the Road to Coronary Microvascular Dysfunction and Beyond ― Reviewed

Masaya Tanno, Arata Osanami

Circulation Journal   86 ( 5 )   874 - 876   2022.4

Ubiquitin-dependent rapid degradation conceals a cell-protective function of cytoplasmic SIRT3 against oxidative stress. Reviewed International journal

Takashi Hayashi, Takashi Matsushita, Shin Hisahara, Naotoshi Iwahara, Atsushi Kuno, Risa Kunimoto, Ryusuke Hosoda, Masaya Tanno, Shun Shimohama, Yoshiyuki Horio

Journal of biochemistry   171 ( 2 )   201 - 213   2022.2

Reduction in GLP-1 secretory capacity may be a novel independent risk factor of coronary artery stenosis. Reviewed International journal

Chihiro Nagase, Masaya Tanno, Hidemichi Kouzu, Takayuki Miki, Junichi Nishida, Naoto Murakami, Nobuaki Kokubu, Nobutaka Nagano, Ryo Nishikawa, Nobuhiro Yoshioka, Tohru Hasegawa, Hiroyuki Kita, Akihito Tsuchida, Hirofumi Ohnishi, Tetsuji Miura

Scientific reports   11 ( 1 )   15578 - 15578   2021.8

Involvement of necroptosis in contrast-induced nephropathy in a rat CKD model. Reviewed

Satoru Shibata, Norihito Moniwa, Atsushi Kuno, Ayumu Kimura, Wataru Ohwada, Hirohito Sugawara, Yufu Gocho, Marenao Tanaka, Toshiyuki Yano, Masato Furuhashi, Masaya Tanno, Takayuki Miki, Tetsuji Miura

Clinical and experimental nephrology   25 ( 7 )   708 - 717   2021.7

Characteristics of patients with emergency attendance for severe hypoglycemia and hyperglycemia in a general hospital in Japan

Keisuke Endo, Takahito Itoh, Masaya Tanno, Kouhei Ohno, Hiroyuki Hotta, Nobuo Kato, Tomoaki Matsumoto, Hitoshi Ooiwa, Hirofumi Kubo, Takayuki Miki

Medicine   100 ( 25 )   e26505   2021.6

Prognostic Value of Abnormalities in the Coagulation/Fibrinolysis Status in Patients after Resuscitation from Out-of-Hospital Cardiac Arrest(和訳中)

中田 潤, 國分 宣明, 永野 伸卓, 西川 諒, 高橋 遼, 岸上 直広, 大友 俊作, 小山 雅之, 丹野 雅也, 三浦 哲嗣

日本循環器学会学術集会抄録集   85回   OJ26 - 6   2021.3

AMPデアミナーゼの細胞内局在化とXORによるROS生成におけるCytosolic AMPDの役割(Intracellular Localization of AMP Deaminase and a Role of Cytosolic AMPD in XOR-mediated ROS Production)

Osanami Arata, Tanno Masaya, Kuno Atsushi, Kouzu Hidemichi, Yano Toshiyuki, Ogawa Toshifumi, Sato Tatsuya, Miura Tetsuji

日本循環器学会学術集会抄録集   85回   OE081 - 6   2021.3

Mitochondrial associated ER membraneにおけるAMPD3の役割とミトコンドリア膜透過性遷移の閾値制御(Role of AMPD3 in Mitochondria-associated ER Membranes in Regulation of Threshold for Mitochondrial Permeability Transition)

Osanami Arata, Tanno Masaya, Kuno Atsushi, Kouzu Hidemichi, Yano Toshiyuki, Ogawa Toshifumi, Sato Tatsuya, Miura Tetsuji

日本循環器学会学術集会抄録集   85回   OE080 - 6   2021.3

ミトコンドリア関連ER膜および細胞質におけるAMPデアミナーゼの上昇は糖尿病心の圧負荷による心機能障害に大きく寄与する(Upregulated AMP Deaminase in Mitochondria-associated ER Membranes and Cytosol Distinctively Contributes to Pressure Overload-induced Cardiac Dysfunction in Diabetic Hearts)

Tanno Masaya, Osanami Arata, Kouzu Hidemichi, Ogawa Toshifumi, Kuno Atsushi, Miura Tetsuji

日本循環器学会学術集会抄録集   85回   SS14 - 4   2021.3

糖尿病腎の心腎症候群type 1への感受性増加におけるTLRs/NOXsシグナル伝達とオートファジー障害の影響(Detrimental Roles of TLRs/NOXs Signaling and Impaired Autophagy in Increased Susceptibility of the Diabetic Kidney to Type 1 Cardiorenal Syndrome)

Kuno Atsushi, Sato Tatsuya, Kouzu Hidemichi, Yano Toshiyuki, Tanno Masaya, Miura Tetsuji

日本循環器学会学術集会抄録集   85回   PL09 - 1   2021.3

院外心停止蘇生後患者における血液凝固/線溶異常の予後的意義(Prognostic Value of Abnormalities in the Coagulation/Fibrinolysis Status in Patients after Resuscitation from Out-of-Hospital Cardiac Arrest)

中田 潤, 國分 宣明, 永野 伸卓, 西川 諒, 高橋 遼, 岸上 直広, 大友 俊作, 小山 雅之, 丹野 雅也, 三浦 哲嗣

日本循環器学会学術集会抄録集   85回   OJ26 - 6   2021.3

Xanthine oxidoreductase-mediated injury is amplified by upregulated AMP deaminase in type 2 diabetic rat hearts under the condition of pressure overload. Reviewed International journal

Yusuke Igaki, Masaya Tanno, Tatsuya Sato, Hidemichi Kouzu, Toshifumi Ogawa, Arata Osanami, Toshiyuki Yano, Atsushi Kuno, Takayuki Miki, Takashi Nakamura, Tetsuji Miura

Journal of molecular and cellular cardiology   154   21 - 31   2021.2

Activation of the angiotensin II receptor promotes autophagy in renal proximal tubular cells and affords protection from ischemia/reperfusion injury Reviewed

Hirohito Sugawara, Norihito Moniwa, Atsushi Kuno, Wataru Ohwada, Arata Osanami, Satoru Shibata, Yukishige Kimura, Koki Abe, Yufu Gocho, Masaya Tanno, Tetsuji Miura

Journal of Pharmacological Sciences   145 ( 2 )   187 - 197   2021.2

経口ブドウ糖負荷試験で診断し得た機能性低血糖症の1例

寺沢 誠, 長南 新太, 佐藤 達也, 原田 なお, 川原田 航, 箱崎 頌平, 後町 結, 茂庭 仁人, 矢野 俊之, 古橋 眞人, 丹野 雅也, 三浦 哲嗣

日本内分泌学会雑誌   96 ( 3 )   596 - 596   2021.1

Distinct intra-mitochondrial localizations of pro-survival kinases and regulation of their functions by DUSP5 and PHLPP-1 Reviewed

Wataru Ohwada, Masaya Tanno, Toshiyuki Yano, Sang-Bing Ong, Koki Abe, Tatsuya Sato, Atsushi Kuno, Takayuki Miki, Hirohito Sugawara, Yusuke Igaki, Tetsuji Miura

Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease   1866 ( 10 )   165851 - 165851   2020.10

非専門医の外来診療における慢性合併症評価率の年次変化

小川 俊史, 佐藤 達也, 三木 隆幸, 東浦 幸村, 伊野 祥哉, 矢野 俊之, 古橋 眞人, 神津 英至, 丹野 雅也, 斎藤 重幸, 三浦 哲嗣

糖尿病   63 ( Suppl.1 )   S - 204   2020.8

非虚血性拡張型心筋症において核内および介在板に局在するnecroptosisの実行因子リン酸化MLKLは各々独立して働いている(Phosphorylated MLKL, an Executor of Necroptosis, Localized in the Nucleus and Intercalated Disc Plays Distinct Roles in Nonischemic Dilated Cardiomyopathy)

Fujita Yugo, Yano Toshiyuki, Nagano Nobutaka, Nishikawa Ryo, Kamiyama Naoyuki, Fujito Takefumi, Mochizuki Atsushi, Koyama Masayuki, Kouzu Hidemichi, Muranaka Atsuko, Nagahara Daigo, Tanno Masaya, Miki Takayuki, Miura Tetsuji

日本循環器学会学術集会抄録集   84回   OE61 - 5   2020.7

ドキソルビシン誘発性心筋症の発症には鉄結合タンパク質ではなく遊離鉄のミトコンドリアへの蓄積が関与している可能性がある(Accumulation of Free Iron, but not Protein-bound Iron, in Mitochondria may Contribute to Development of Doxorubicin-induced Cardiomyopathy)

Sato Tatsuya, Kikuchi Tatsuya, Yano Toshiyuki, Miki Takayuki, Tanno Masaya, Kuno Atsushi, Kouzu Hidemichi, Miura Tetsuji

日本循環器学会学術集会抄録集   84回   PE48 - 7   2020.7

糖尿病外来診療における慢性合併症評価の実態調査

小川 俊史, 佐藤 達也, 東浦 幸村, 伊野 祥哉, 矢野 俊之, 古橋 眞人, 丹野 雅也, 三木 隆幸, 斎藤 重幸, 三浦 哲嗣

糖尿病   63 ( 5 )   356 - 356   2020.5

mTORC1 inhibition attenuates necroptosis through RIP1 inhibition-mediated TFEB activation Reviewed

Abe K, Yano T, Tanno M, Miki T, Kuno A, Sato T, Kouzu H, Nakata K, Ohwada W, Kimura Y, Sugawara H, Shibata S, Igaki Y, Ino S, Miura T

BBA Molecular Basis of Disease   1865 ( 12 )   165552   2019.12

心不全と心腎連関における髄質集合管バソプレシンV2受容体の役割 BOREAS-ADHFレジストリ解析結果より

丹野 雅也, 永野 伸卓, 能登 貴弘, 長南 新太, 神津 英至, 三浦 哲嗣

日本心臓病学会学術集会抄録   67回   SS - 3   2019.9

Canagliflozin, an SGLT2 inhibitor, normalizes renal susceptibility to type 1 cardiorenal syndrome through reduction of renal oxidative stress in diabetic rats. Reviewed

Kimura Y, Kuno A, Tanno M, Sato T, Ohno K, Shibata S, Nakata K, Sugawara H, Abe K, Igaki Y, Yano T, Miki T, Miura T

Journal of Diabetes Investigation   10 ( 4 )   933 - 946   2019.7

mTORC1活性阻害はRIP1の抑制的リン酸化により心筋細胞のネクロプトーシスを抑制する

矢野 俊之, 安倍 功記, 佐藤 達也, 神津 英至, 久野 篤史, 丹野 雅也, 三木 隆幸, 三浦 哲嗣

日本循環制御医学会総会プログラム・抄録集   40回   63 - 63   2019.6

AKIに対するアンジオテンシンII前投与による腎保護効果はAT1およびMas受容体減少の軽減とautophagy活性化を伴う

菅原 浩仁, 茂庭 仁人, 柴田 智, 矢野 俊之, 久野 篤史, 丹野 雅也, 三木 隆幸, 三浦 哲嗣

日本腎臓学会誌   61 ( 3 )   285 - 285   2019.5

Accuracy of flash glucose monitoring in insulin-treated patients with type 2 diabetes. Reviewed

Tatsuya Sato, Hiroto Oshima, Kei Nakata, Yukishige Kimura, Toshiyuki Yano, Masato Furuhashi, Masaya Tanno, Takayuki Miki, Tetsuji Miura

Journal of diabetes investigation   10 ( 3 )   846 - 850   2019.5

糖尿病の外来診療における慢性合併症評価実態の検討

伊野 祥哉, 中田 圭, 東浦 幸村, 佐藤 達也, 矢野 俊之, 古橋 眞人, 丹野 雅也, 三木 隆幸, 斎藤 重幸, 三浦 哲嗣

糖尿病   62 ( Suppl.1 )   S - 306   2019.4

Empagliflozin, an SGLT2 inhibitor, reduced the mortality rate after acute myocardial infarction with modification of cardiac metabolomes and anti-oxidants in diabetic rats. Reviewed

Oshima H, Miki T, Kuno A, Mizuno M, Sato T, Tanno M, Yano T, Nakata K, Kimura Y, Abe K, Ohwada W, Miura T

The Journal of pharmacology and experimental therapeutics   368 ( 3 )   524 - 534   2019.3

エピジェネティクスにおけるNon-coding RNA 糖尿病性心筋症の重要因子であるAMP deaminaseの新規microRNA介在性制御(Non-coding RNAs as Regulators in Epigenetics Novel microRNA-mediated Regulation of AMP Deaminase, a Key Player in Diabetic Cardiomyopathy)

Tanno Masaya, Tatekoshi Yuki, Kouzu Hidemichi, Kuno Atsushi, Yano Toshiyuki, Miki Takayuki, Miura Tetsuji

日本循環器学会学術集会抄録集   83回   SY14 - 4   2019.3

JDS-JCSジョイントシンポ(Controversy or Debate)-"Stop DM for Stop CVD"生命予後改善のための糖尿病管理とは 心血管イベントリスクの高い糖尿病患者を検出するためのECG検査の重要性とSGLT2阻害薬によって得られる利点(Importance of ECG Examination to Detect High Risk Diabetic Patients for Cardiovascular Events and Their Benefit Afforded by SGLT2 Inhibitors)

三木 隆幸, 佐藤 達也, 大西 浩文, 矢野 俊之, 中田 圭, 丹野 雅也, 三浦 哲嗣

日本循環器学会学術集会抄録集   83回   SY12 - 3   2019.3

バソプレシンV2受容体機能が維持された心不全患者において、トルバプタンの早期開始は長期予後を改善する

能登 貴弘, 丹野 雅也, 永野 伸卓, 長南 新太, 神津 英至, 三浦 哲嗣

日本内科学会雑誌   108 ( Suppl. )   265 - 265   2019.2

【心不全(第2版)上-最新の基礎・臨床研究の進歩-】心不全の基礎研究 心不全の分子機序 心筋リモデリング DNA・転写制御障害 Sirtuin

丹野 雅也, 久野 篤史

日本臨床   76 ( 増刊9 心不全(上) )   325 - 330   2018.12

Does p53 Inhibition Suppress Myocardial Ischemia-Reperfusion Injury? Reviewed

Yano T, Abe K, Tanno M, Miki T, Kuno A, Miura T, Steenbergen C

Journal of cardiovascular pharmacology and therapeutics   23 ( 4 )   350 - 357   2018.7

Empagliflozin normalizes the size and number of mitochondria and prevents reduction in mitochondrial size after myocardial infarction in diabetic hearts. Reviewed

Mizuno M, Kuno A, Yano T, Miki T, Oshima H, Sato T, Nakata K, Kimura Y, Tanno M, Miura T

Physiological Reports   6 ( 12 )   e13741   2018.6

Translational regulation by miR-301b upregulates AMP deaminase in diabetic hearts. Reviewed

Tatekoshi Y, Tanno M, Kouzu H, Abe K, Miki T, Kuno A, Yano T, Ishikawa S, Ohwada W, Sato T, Niinuma T, Suzuki H, Miura T

Journal of Molecular and Cellular Cardiology   119   138 - 146   2018.6

アンジオテンシンIIの短期投与は尿細管autophagyを活性化し,急性腎障害を軽減する

菅原 浩仁, 茂庭 仁人, 柴田 智, 木村 幸滋, 山下 智久, 矢野 俊之, 久野 篤史, 丹野 雅也, 三木 隆幸, 三浦 哲嗣

日本腎臓学会誌   60 ( 3 )   460 - 460   2018.4

糖尿病が重症急性心不全の予後に及ぼす影響

柴田 智, 三木 隆幸, 山下 智久, 菅原 浩仁, 佐藤 達也, 大島 洸人, 矢野 俊之, 丹野 雅也, 三浦 哲嗣

糖尿病   61 ( Suppl.1 )   S - 426   2018.4

Distinct impacts of sleep-disordered breathing on glycemic variability in patients with and without diabetes mellitus Reviewed

Kei Nakata, Takayuki Miki, Masaya Tanno, Hirofumi Ohnishi, Toshiyuki Yano, Atsuko Muranaka, Tatsuya Sato, Hiroto Oshima, Yuki Tatekoshi, Masashi Mizuno, Koki Abe, Tetsuji Miura

PLOS ONE   12 ( 12 )   e0188689   2017.12

Diabetes increases the susceptibility to acute kidney injury after myocardial infarction through augmented activation of renal Toll-like receptors in rats Reviewed

Kouhei Ohno, Atsushi Kuno, Hiromichi Murase, Shingo Muratsubaki, Takayuki Miki, Masaya Tanno, Toshiyuki Yano, Satoko Ishikawa, Tomohisa Yamashita, Tetsuji Miura

AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY   313 ( 6 )   H1130 - H1142   2017.12

Effect of sodium-glucose co-transporter-2 inhibitors on impaired ventricular repolarization in people with Type 2 diabetes Reviewed

T. Sato, T. Miki, H. Ohnishi, T. Yamashita, A. Takada, T. Yano, M. Tanno, A. Tsuchida, T. Miura

DIABETIC MEDICINE   34 ( 10 )   1367 - 1371   2017.10

循環器内科学 心不全の発症進展におけるAMPデアミナーゼの役割

舘越 勇輝, 丹野 雅也

医学のあゆみ   262 ( 3 )   243 - 244   2017.7

Suppression of autophagic flux contributes to cardiomyocyte death by activation of necroptotic pathways. Reviewed

Ogasawara M, Yano T, Tanno M, Abe K, Ishikawa S, Miki T, Kuno A, Tobisawa T, Muratsubaki S, Ohno K, Tatekoshi Y, Nakata K, Ohwada W, Miura T

Journal of molecular and cellular cardiology   108   203 - 213   2017.7

Suppressed autophagic response underlies augmentation of renal ischemia/reperfusion injury by type 2 diabetes Reviewed

Shingo Muratsubaki, Atsushi Kuno, Masaya Tanno, Takayuki Miki, Toshiyuki Yano, Hirohito Sugawara, Satoru Shibata, Koki Abe, Satoko Ishikawa, Kouhei Ohno, Yukishige Kimura, Yuki Tatekoshi, Kei Nakata, Wataru Ohwada, Masashi Mizuno, Tetsuji Miura

SCIENTIFIC REPORTS   7 ( 1 )   5311   2017.7

Insufficient activation of Akt upon reperfusion because of its novel modification by reduced PP2A-B55 alpha contributes to enlargement of infarct size by chronic kidney disease Reviewed

Toshiyuki Tobisawa, Toshiyuki Yano, Masaya Tanno, Takayuki Miki, Atsushi Kuno, Yukishige Kimura, Satoko Ishikawa, Hidemichi Kouzu, Keitaro Nishizawa, Hideaki Yoshida, Tetsuji Miura

BASIC RESEARCH IN CARDIOLOGY   112 ( 3 )   31   2017.5

多腺性自己免疫症候群3A型に房室ブロックを合併した一例 抗Ro/SS-A抗体との関連

中田 圭, 矢野 俊之, 大島 洸人, 古橋 眞人, 丹野 雅也, 斎藤 重幸, 三木 隆幸, 三浦 哲嗣

糖尿病   60 ( Suppl.1 )   S - 452   2017.4

2型糖尿病による腎虚血再灌流障害の増悪におけるautophagy障害の役割

菅原 浩仁, 茂庭 仁人, 柴田 智, 山下 智久, 村椿 真悟, 久野 篤史, 矢野 俊之, 丹野 雅也, 三木 隆幸, 三浦 哲嗣

日本腎臓学会誌   59 ( 3 )   226 - 226   2017.4

Toll様受容体の活性化により2型糖尿病における心筋梗塞後のAKIに対する腎臓の感受性が増大する(Increased Renal Susceptibility to AKI after Myocardial Infarction in Type 2 Diabetes is Mediated by Augmented Activation of Toll-like Receptors)

大野 紘平, 久野 篤史, 三木 隆幸, 丹野 雅也, 矢野 俊之, 大和田 渉, 木村 幸滋, 安部 功記, 中田 圭, 舘越 勇輝, 三浦 哲嗣

日本循環器学会学術集会抄録集   81回   PJ - 594   2017.3

多発性脳梗塞にて発症し、診断と治療効果の指標にPET-CTが有用であったLoeffler心内膜心筋炎の1例

大岩 修太郎, 茂庭 仁人, 能登 貴弘, 瀬野 結, 永野 伸卓, 神津 英至, 村中 敦子, 矢野 俊之, 丹野 雅也, 三浦 哲嗣

心臓   49 ( 3 )   253 - 259   2017.3

Distinct risk factors of atrial fibrillation in patients with and without coronary artery disease: A cross-sectional analysis of the BOREAS-CAG Registry data Reviewed

Naoto Murakami, Masaya Tanno, Nobuaki Kokubu, Junichi Nishida, Nobutaka Nagano, Hirofumi Ohnishi, Hiroshi Akasaka, Takayuki Miki, Kazufumi Tsuchihashi, Tetsuji Miura

Open Heart   4 ( 1 )   e000573   2017

Chronic Treatment With an Erythropoietin Receptor Ligand Prevents Chronic Kidney Disease-Induced Enlargement of Myocardial Infarct Size. Reviewed

Nishizawa K, Yano T, Tanno M, Miki T, Kuno A, Tobisawa T, Ogasawara M, Muratsubaki S, Ohno K, Ishikawa S, Miura T

Hypertension (Dallas, Tex. : 1979)   68 ( 3 )   697 - 706   2016.9

糖尿病が腎虚血再灌流障害に及ぼす影響 オートファジーとの関連

村椿 真悟, 久野 篤史, 大野 紘平, 丹野 雅也, 矢野 俊之, 水野 雅司, 西沢 慶太郎, 大和田 渉, 舘越 勇輝, 中田 圭, 三木 隆幸, 三浦 哲嗣

日本腎臓学会誌   58 ( 3 )   276 - 276   2016.5

睡眠呼吸障害が血糖変動に与える影響の検討

中田 圭, 丹野 雅也, 矢野 俊之, 小笠原 淳, 赤坂 憲, 古橋 眞人, 三木 隆幸, 三浦 哲嗣

糖尿病   59 ( Suppl.1 )   S - 191   2016.4

糖尿病心臓のAMP deaminaseの活性化においては翻訳後修飾ではなくfructose 1,6-diphosphateの枯渇が主要な役割を果たす(Depletion of Fructose 1,6-diphosphate but not Post-translational Modification Plays a Major Role in Activation of AMP Deaminase in Diabetic Hearts)

Tatekoshi Yuki, Kouzu Hidemichi, Tanno Masaya, Kuno Atsushi, Ishikawa Satoko, Yano Toshiyuki, Miki Takayuki, Ogasawara Makoto, Tobisawa Toshiyuki, Ono Kouhei, Muratsubaki Shingo, Nishizawa Keitaro, Miura Tetsuji

Circulation Journal   80 ( Suppl.I )   1115 - 1115   2016.3

RIP1によるp62の隔離はオートファジーの流れを障害し、心筋細胞におけるRIP1依存的ネクロトーシスにつながる(Sequestration of p62 by RIP1 Impairs Autophagic Flux and Leads to RIP1-dependent Necroptosis in Cardiomyocytes)

Ogasawara Makoto, Yano Toshiyuki, Miki Takayuki, Tanno Masaya, Kuno Atsushi, Kouzu Hidemichi, Tobisawa Toshiyuki, Muratsubaki Shingo, Ono Kouhei, Nishizawa Keitaro, Ishikawa Satoko, Miura Tetsuji

Circulation Journal   80 ( Suppl.I )   2404 - 2404   2016.3

2型糖尿病初期ではAMI誘発性急性腎障害に対する感受性がTLR介在性メカニズムによって増加する(Susceptibility to AMI-induced Acute Kidney Injury is Increased by a TLR-mediated Mechanism in the Early Stage of Type 2 Diabetes)

Ono Kouhei, Kuno Atsushi, Miki Takayuki, Tanno Masaya, Yano Toshiyuki, Kouzu Hidemichi, Ogasawara Makoto, Tobisawa Toshiyuki, Muratsubaki Shingo, Nishizawa Keitaro, Miura Tetsuji

Circulation Journal   80 ( Suppl.I )   1352 - 1352   2016.3

Clinical impact of myocardial mTORC1 activation in nonischemic dilated cardiomyopathy Reviewed

Toshiyuki Yano, Shinya Shimoshige, Takayuki Miki, Masaya Tanno, Atsushi Mochizuki, Takefumi Fujito, Satoshi Yuda, Atsuko Muranaka, Makoto Ogasawara, Akiyoshi Hashimoto, Kazufumi Tsuchihashi, Tetsuji Miura

JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY   91   6 - 9   2016.2

Inhibition of DPP-4 reduces acute mortality after myocardial infarction with restoration of autophagic response in type 2 diabetic rats. Reviewed

Murase H, Kuno A, Miki T, Tanno M, Yano T, Kouzu H, Ishikawa S, Tobisawa T, Ogasawara M, Nishizawa K, Miura T

Cardiovascular diabetology   14   103   2015.8

早期2型糖尿病腎ではオートファジーが亢進している

村椿 真悟, 久野 篤史, 大野 紘平, 丹野 雅也, 矢野 俊之, 神津 英至, 田中 希尚, 飛澤 利之, 小笠原 惇, 西沢 慶太郎, 石川 聡子, 三木 隆幸, 三浦 哲嗣

日本腎臓学会誌   57 ( 3 )   569 - 569   2015.4

心筋梗塞による急性腎障害に対する2型糖尿病の影響と死亡率の関連

大野 紘平, 久野 篤史, 村椿 真悟, 村瀬 弘通, 丹野 雅也, 矢野 俊之, 神津 英至, 飛澤 利之, 小笠原 惇, 西澤 慶太郎, 石川 聡子, 田中 希尚, 三木 隆幸, 三浦 哲嗣

日本腎臓学会誌   57 ( 3 )   569 - 569   2015.4

慢性腎不全の虚血/再灌流障害への感受性亢進において再灌流中のmTORC2活性化障害は中心的な役割を果たす(Impairment of mTORC2 Activation upon Reperfusion Plays a Pivotal Role in Increased Susceptibility to Ischemia/Reperfusion Injury in Chronic Renal Failure)

Tobisawa Toshiyuki, Yano Toshiyuki, Miki Takayuki, Tanno Masaya, Kuno Atsushi, Kouzu Hidemichi, Ogasawara Makoto, Muratsubaki Shingo, Nishizawa Keutarou, Sugawara Hirohito, Ishikawa Satoko, Yoshida Hideaki, Miura Tetsuji

Circulation Journal   79 ( Suppl.I )   2071 - 2071   2015.3

Excessive degradation of adenine nucleotides by up-regulated AMP deaminase underlies afterload-induced diastolic dysfunction in the type 2 diabetic heart. Reviewed

Kouzu H, Miki T, Tanno M, Kuno A, Yano T, Itoh T, Sato T, Sunaga D, Murase H, Tobisawa T, Ogasawara M, Ishikawa S, Miura T

Journal of molecular and cellular cardiology   80   136 - 145   2015.3

The effects of resveratrol and SIRT1 activation on dystrophic cardiomyopathy Reviewed

Atsushi Kuno, Masaya Tanno, Yoshiyuki Horio

RESVERATROL AND HEALTH   1348   46 - 54   2015

Translocation of Glycogen Synthase Kinase-3 beta (GSK-3 beta), a Trigger of Permeability Transition, Is Kinase Activity-dependent and Mediated by Interaction with Voltage-dependent Anion Channel 2 (VDAC2) Reviewed

Tanno Masaya, Kuno Atsushi, Ishikawa Satoko, Miki Takayuki, Kouzu Hidemichi, Yano Toshiyuki, Murase Hiromichi, Tobisawa Toshiyuki, Ogasawara Makoto, Horio Yoshiyuki, Miura Tetsuji

JOURNAL OF BIOLOGICAL CHEMISTRY   289 ( 42 )   29285 - 29296   2014.10

Does glycemic control reverse dispersion of ventricular repolarization in type 2 diabetes? Reviewed

Takayuki Miki, Toshiyuki Tobisawa, Tatsuya Sato, Masaya Tanno, Toshiyuki Yano, Hiroshi Akasaka, Atsushi Kuno, Makoto Ogasawara, Hiromichi Murase, Shigeyuki Saitoh, Tetsuji Miura

CARDIOVASCULAR DIABETOLOGY   13   125   2014.8

Type 2 diabetes induces subendocardium-predominant reduction in transient outward K+ current with downregulation of Kv4.2 and KChIP2. Reviewed

Sato T, Kobayashi T, Kuno A, Miki T, Tanno M, Kouzu H, Itoh T, Ishikawa S, Kojima T, Miura T, Tohse N

American journal of physiology. Heart and circulatory physiology   306 ( 7 )   H1054 - 65   2014.4

ミトコンドリアKATPチャンネル活性化による酸化ストレス後のmPTP再閉鎖促進は残存ROS産生の抑制により達成される(Acceleration of mPTP Re-closure after Oxidant Stress by Mitochondrial KATP Channel Activation is Achieved by Suppression of Residual ROS Production)

Ogasawara Makoto, Tanno Masaya, Kuno Atsushi, Ishikawa Satoko, Murase Hiromichi, Tobisawa Toshiyuki, Kouzu Hidemichi, Yano Toshiyuki, Miki Takayuki, Miura Tetsuji

Circulation Journal   78 ( Suppl.I )   323 - 324   2014.3

糖尿病ラットにおいてIncretinを中心とする治療により心筋オートファジーフラックスが回復し、心筋梗塞後の死亡率が減少する(Incretin-based Therapy Restores Myocardial Autophagic Flux and Reduces Mortality after Myocardial Infarction in Diabetic Rats)

Murase Hiromichi, Kuno Atsushi, Miki Takayuki, Tanno Masaya, Yano Toshiyuki, Kouzu Hidemichi, Tobisawa Toshiyuki, Ogasawara Makoto, Ishikawa Satoko, Miura Tetsuji

Circulation Journal   78 ( Suppl.I )   401 - 402   2014.3

慢性腎不全は虚血/再灌流傷害に対する心筋感受性を高める(Chronic Renal Failure Enhances Myocardial Susceptibility to Ischemia/Reperfusion Injury)

Tobisawa Toshiyuki, Yano Toshiyuki, Miki Takayuki, Tanno Masaya, Kuno Atsushi, Kouzu Hidemichi, Murase Hiromichi, Ogasawara Makoto, Ishikawa Satoko, Yoshida Hideaki, Miura Tetsuji

Circulation Journal   78 ( Suppl.I )   269 - 269   2014.3

心保護シグナル伝達におけるmTORC2およびリボソーム蛋白質S6の中心的役割(The Pivotal Role of mTORC2 and Ribosomal Protein S6 in Cardioprotective Signaling)

Yano Toshiyuki, Miki Takayuki, Tanno Masaya, Kuno Atsushi, Kouzu Hidemichi, Murase Hiromichi, Ogasawara Makoto, Tobisawa Toshiyuki, Ishikawa Satoko, Miura Tetsuji

Circulation Journal   78 ( Suppl.I )   470 - 470   2014.3

Accelerated recovery of mitochondrial membrane potential by GSK-3β inactivation affords cardiomyocytes protection from oxidant-induced necrosis. Reviewed

Sunaga D, Tanno M, Kuno A, Ishikawa S, Ogasawara M, Yano T, Miki T, Miura T

PloS one   9 ( 11 )   e112529   2014

2型糖尿病の心筋におけるミトコンドリア蛋白脱アセチル化酵素SIRT3の役割(Role of SIRT3, a Mitochondrial Protein Deacetylase, in Type 2 Diabetic Myocardium)

Kuno Atsushi, Itoh Takahito, Sato Tatsuya, Kouzu Hidemichi, Tanno Masaya, Miki Takayuki, Horio Yoshiyuki, Miura Tetsuji

Circulation Journal   77 ( Suppl.I )   168 - 168   2013.3

虚血中のcyclophilin Dと無機リン酸担体の相互作用はmPTP開口の閾値と再灌流誘発性細胞壊死を決定する(Interaction of Cyclophilin D with Inorganic Phosphate Carrier during Ischemia Determines Threshold for mPTP Opening and Reperfusion-induced Cell Necrosis)

Itoh Takahito, Miki Takayuki, Tanno Masaya, Kuno Atsushi, Kouzu Hidemichi, Sato Tatsuya, Sunaga Daisuke, Murase Hiromichi, Ishikawa Satoko, Miura Tetsuji

Circulation Journal   77 ( Suppl.I )   45 - 45   2013.3

VDAC2との相互作用はGSK3Bのミトコンドリア移行をキナーゼ活性依存性に促進し、細胞死を誘発する(Interaction with VDAC2 Promotes Mitochondrial Translocation of GSK3β in a Kinase Activity-Dependent Manner and Induces Cell Death)

Tanno Masaya, Sunaga Daisuke, Ishikawa Satoko, Itoh Takahito, Kouzu Hidemichi, Sato Tatsuya, Kuno Atsushi, Murase Hiromichi, Miki Takayuki, Miura Tetsuji

Circulation Journal   77 ( Suppl.I )   55 - 56   2013.3

mPTP再閉鎖の促進はROS誘発性壊死を防ぐミトコンドリアKATPチャネルの活性化によって心筋細胞を防御する(Promotion of Re-closure of the mPTP Underlies Cardiomyocyte Protection by Activation of the Mitochondrial KATP Channel against ROS-induced Necrosis)

Sunaga Daisuke, Kuno Atsushi, Ishikawa Satoko, Miki Takayuki, Tanno Masaya, Kouzu Hidemichi, Itoh Takahito, Sato Tatsuya, Murase Hiromichi, Miura Tetsuji

Circulation Journal   77 ( Suppl.I )   245 - 245   2013.3

Titinによる心室スティフネスの変化は、2型糖尿病心臓における急性収縮期圧負荷により示された拡張機能障害を生じる可能性がある(Changes in Titin-based Ventricular Stiffness May Underlie Diastolic Dysfunction Unmasked by Acute Systolic Pressure Overloading in Type 2 Diabetic Hearts)

Kouzu Hidemichi, Kuno Atsushi, Miki Takayuki, Tanno Masaya, Itoh Takahito, Sato Tatsuya, Sunaga Daisuke, Murase Hiromichi, Miura Tetsuji

Circulation Journal   77 ( Suppl.I )   64 - 64   2013.3

Resveratrol improves cardiomyopathy in dystrophin-deficient mice through SIRT1 protein-mediated modulation of p300 protein. Reviewed

Kuno A, Hori YS, Hosoda R, Tanno M, Miura T, Shimamoto K, Horio Y

The Journal of biological chemistry   288 ( 8 )   5963 - 5972   2013.2

特発性右房拡張症の1例

菅原 浩仁, 小笠原 惇, 村中 敦子, 川向 美奈, 望月 敦史, 伊藤 孝仁, 丹野 雅也, 下重 晋也, 湯田 聡, 橋本 暁佳, 土橋 和文, 三浦 哲嗣

超音波医学   40 ( 1 )   33 - 33   2013.1

Histopathology of the pancreas in fulminant type 1 diabetes after 23-year follow-up: a case report Reviewed

Tatsuya Sato, Takayuki Miki, Naoto Murakami, Yoshihiko Hirohashi, Hidemichi Kouzu, Masato Furuhashi, Masaya Tanno, Satoshi Yuda, Shigeyuki Saitoh, Tadashi Hasegawa, Tetsuji Miura

PATHOLOGY INTERNATIONAL   62 ( 12 )   827 - 829   2012.12

Cytoprotective regulation of the mitochondrial permeability transition pore is impaired in type 2 diabetic Goto-Kakizaki rat hearts. Reviewed

Itoh T, Kouzu H, Miki T, Tanno M, Kuno A, Sato T, Sunaga D, Murase H, Miura T

Journal of molecular and cellular cardiology   53 ( 6 )   870 - 879   2012.12

軽度血圧上昇を伴う肥満2型糖尿病が左室・動脈カップリングに及ぼす影響

神津 英至, 須永 大介, 高田 明典, 久野 篤史, 丹野 雅也, 三木 隆幸, 三浦 哲嗣

日本高血圧学会総会プログラム・抄録集   35回   475 - 475   2012.9

Emerging beneficial roles of sirtuins in heart failure. Reviewed

Tanno M, Kuno A, Horio Y, Miura T

Basic research in cardiology   107 ( 4 )   273   2012.7

Role of connexin-43 in protective PI3K-Akt-GSK-3β signaling in cardiomyocytes. Reviewed

Ishikawa S, Kuno A, Tanno M, Miki T, Kouzu H, Itoh T, Sato T, Sunaga D, Murase H, Miura T

American journal of physiology. Heart and circulatory physiology   302 ( 12 )   H2536 - 44   2012.6

The mPTP and its regulatory proteins: final common targets of signalling pathways for protection against necrosis Reviewed

Tetsuji Miura, Masaya Tanno

CARDIOVASCULAR RESEARCH   94 ( 2 )   181 - 189   2012.5

糖尿病の心臓において、無機リン酸輸送体のANTおよびシクロフィリンDとの相互作用増大がmPTP調節異常の根底にある(Increased Interaction of Inorganic Phosphate Carrier with ANT and Cyclophilin D Underlies Dysregulation of the mPTP in Diabetetic Hearts)

Itoh Takahito, Kouzu Hidemichi, Miki Takayuki, Tanno Masaya, Kuno Atsushi, Satoh Tatsuya, Sunaga Daisuke, Murase Hiromichi, Ishikawa Satoko, Miura Tetsuji

Circulation Journal   76 ( Suppl.I )   2171 - 2171   2012.3

Ito電流は肥満2型糖尿病においてKv4.2およびKChIP2のダウンレギュレーションにより心内膜下で選択的に低下する(The Ito Current is Reduced Selectively in the Subendocardium by Downregulation of Kv4.2 and KChIP2 in Obese Type 2 Diabetes)

Sato Tatsuya, Miki Takayuki, Tanno Masaya, Kuno Atsushi, Kobayashi Takeshi, Kouzu Hidemichi, Itoh Takahito, Sunaga Daisuke, Murase Hiromichi, Ishikawa Satoko, Miura Tetsuji, Tohse Noritsugu

Circulation Journal   76 ( Suppl.I )   1592 - 1592   2012.3

Ser9位のGSK-3βのリン酸化はミトコンドリアへの移行を阻害し、ミトコンドリアによる致死性ROS産生を減弱する(Phosphorylation of GSK-3β at Ser9 Inhibits Its Translocation to Mitochondria and Attenuates Lethal ROS Production by Mitochondria)

Tanno Masaya, Miki Takayuki, Kuno Atsushi, Kouzu Hidemichi, Itoh Takahito, Satoh Tatsuya, Ishikawa Satoko, Sunaga Daisuke

Circulation Journal   76 ( Suppl.I )   943 - 943   2012.3

Role of ER stress in ventricular contractile dysfunction in type 2 diabetes. Reviewed

Takada A, Miki T, Kuno A, Kouzu H, Sunaga D, Itoh T, Tanno M, Yano T, Sato T, Ishikawa S, Miura T

PloS one   7 ( 6 )   e39893   2012

Resveratrol ameliorates muscular pathology in the dystrophic mdx mouse, a model for Duchenne muscular dystrophy. Reviewed

Hori YS, Kuno A, Hosoda R, Tanno M, Miura T, Shimamoto K, Horio Y

The Journal of pharmacology and experimental therapeutics   338 ( 3 )   784 - 794   2011.9

2型糖尿病におけるerythropoietinに対する心筋反応欠如の根底にはミトコンドリア膜透過性遷移孔のERストレス介在性の異常調節がある(ER Stress-mediated Dysregulation of the Mitochondrial Permeability Transition Pore Underlies Loss of Myocardial Response to Erythropoietin in Type 2 Diabetes)

Kouzu Hidemichi, Miki Takayuki, Tanno Masaya, Yano Toshiyuki, Kuno Atsushi, Itoh Takahito, Sato Tatsuya, Takada Akifumi, Ishikawa Satoko, Miura Tetsuji

Circulation Journal   75 ( Suppl.I )   17 - 17   2011.3

軽度の心室機能不全とadrenalin刺激に対する反応鈍化は肥満2型糖尿病における心筋梗塞後の高い死亡率の素因となる(Slight Ventricular Dysfunction and Blunted Response to Adrenergic Stimulation Predispose to Higher Mortality after Infarction in Obese Type 2 Diabetes)

Takada Akifumi, Miki Takayuki, Tanno Masaya, Kuno Atsushi, Kohzu Hidemichi, Itoh Takahito, Satoh Tatsuya, Sunaga Daisuke, Miura Tetsuji

Circulation Journal   75 ( Suppl.I )   44 - 44   2011.3

Hypertensive hypertrophied myocardium is vulnerable to infarction and refractory to erythropoietin-induced protection. Reviewed

Yano T, Miki T, Tanno M, Kuno A, Itoh T, Takada A, Sato T, Kouzu H, Shimamoto K, Miura T

Hypertension (Dallas, Tex. : 1979)   57 ( 1 )   110 - 115   2011.1

Erythropoietin (EPO) affords more potent cardioprotection by activation of distinct signaling to mitochondrial kinases compared with carbamylated EPO. Reviewed

Sato T, Tanno M, Miki T, Yano T, Sato T, Shimamoto K, Miura T

Cardiovascular drugs and therapy / sponsored by the International Society of Cardiovascular Pharmacotherapy   24   401 - 408   2010.12

Roles of phospho-GSK-3β in myocardial protection afforded by activation of the mitochondrial K ATP channel. Reviewed

Terashima Y, Sato T, Yano T, Maas O, Itoh T, Miki T, Tanno M, Kuno A, Shimamoto K, Miura T

Journal of molecular and cellular cardiology   49 ( 5 )   762 - 770   2010.11

Mitochondrial kinase signalling pathways in myocardial protection from ischaemia/reperfusion-induced necrosis Reviewed

Tetsuji Miura, Masaya Tanno, Tatsuya Sato

CARDIOVASCULAR RESEARCH   88 ( 1 )   7 - 15   2010.10

Protein deacetylase SIRT1 in the cytoplasm promotes nerve growth factor-induced neurite outgrowth in PC12 cells Reviewed

Toshiya Sugino, Mitsuhisa Maruyama, Masaya Tanno, Atsushi Kuno, Kiyohiro Houkin, Yoshiyuki Horio

FEBS LETTERS   584 ( 13 )   2821 - 2826   2010.7

Protein deacetylase SIRT1 in the cytoplasm promotes nerve growth factor-induced neurite outgrowth in PC12 cells. Reviewed

Sugino T, Maruyama M, Tanno M, Kuno A, Houkin K, Horio Y

FEBS letters   584 ( 13 )   2821 - 2826   2010.7

Mitochondria and GSK-3beta in cardioprotection against ischemia/reperfusion injury. Reviewed

Miura T, Tanno M

Cardiovascular drugs and therapy / sponsored by the International Society of Cardiovascular Pharmacotherapy   24   255 - 263   2010.6

Induction of manganese superoxide dismutase by nuclear translocation and activation of SIRT1 promotes cell survival in chronic heart failure. Reviewed

Tanno M, Kuno A, Yano T, Miura T, Hisahara S, Ishikawa S, Shimamoto K, Horio Y

The Journal of biological chemistry   285 ( 11 )   8375 - 8382   2010.3

Angiotensin II type 1 receptor-mediated upregulation of calcineurin activity underlies impairment of cardioprotective signaling in diabetic hearts. Reviewed

Hotta H, Miura T, Miki T, Togashi N, Maeda T, Kim SJ, Tanno M, Yano T, Kuno A, Itoh T, Satoh T, Terashima Y, Ishikawa S, Shimamoto K

Circulation research   106 ( 1 )   129 - 132   2010.1

Endoplasmic reticulum stress in diabetic hearts abolishes erythropoietin-induced myocardial protection by impairment of phospho-glycogen synthase kinase-3beta-mediated suppression of mitochondrial permeability transition. Reviewed

Miki T, Miura T, Hotta H, Tanno M, Yano T, Sato T, Terashima Y, Takada A, Ishikawa S, Shimamoto K

Diabetes   58   2863 - 2872   2009.12

Roles of Cx43-associated protein kinases in suppression of gap junction-mediated chemical coupling by ischemic preconditioning. Reviewed

Naitoh K, Yano T, Miura T, Itoh T, Miki T, Tanno M, Sato T, Hotta H, Terashima Y, Shimamoto K

American journal of physiology. Heart and circulatory physiology   296   H396 - 403   2009.2

Ser9 phosphorylation of mitochondrial GSK-3beta is a primary mechanism of cardiomyocyte protection by erythropoietin against oxidant-induced apoptosis. Reviewed

Ohori K, Miura T, Tanno M, Miki T, Sato T, Ishikawa S, Horio Y, Shimamoto K

American journal of physiology. Heart and circulatory physiology   295   H2079 - 86   2008.11

Histone deacetylase SIRT1 modulates neuronal differentiation by its nuclear translocation Reviewed

Shin Hisahara, Susumu Chiba, Hiroyuki Matsumoto, Masaya Tanno, Hideshi Yagi, Shun Shimohama, Makoto Sato, Yoshiyuki Horio

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA   105 ( 40 )   15599 - 15604   2008.10

Adenine nucleotide translocator, a mitochondrial carrier protein, and fate of cardiomyocytes after ischaemia/reperfusion Reviewed

Masaya Tanno, Tetsuji Miura

CARDIOVASCULAR RESEARCH   80 ( 1 )   1 - 2   2008.10

Limitation of infarct size by erythropoietin is associated with translocation of Akt to the mitochondria after reperfusion. Reviewed

Kobayashi H, Miura T, Ishida H, Miki T, Tanno M, Yano T, Sato T, Hotta H, Shimamoto K

Clinical and experimental pharmacology & physiology   35   812 - 819   2008.7

Modulation of the mitochondrial permeability transition pore complex in GSK-3beta-mediated myocardial protection. Reviewed

Nishihara M, Miura T, Miki T, Tanno M, Yano T, Naitoh K, Ohori K, Hotta H, Terashima Y, Shimamoto K

Journal of molecular and cellular cardiology   43   564 - 570   2007.11

Delta-opioid receptor activation before ischemia reduces gap junction permeability in ischemic myocardium by PKC-epsilon-mediated phosphorylation of connexin 43. Reviewed

Miura T, Yano T, Naitoh K, Nishihara M, Miki T, Tanno M, Shimamoto K

American journal of physiology. Heart and circulatory physiology   293   H1425 - 31   2007.9

Protecting ischemic hearts by modulation of SR calcium handling Reviewed

Masaya Tanno, Tetsuji Miura

CARDIOVASCULAR RESEARCH   75 ( 3 )   453 - 454   2007.8

Impairment of cardioprotective PI3K-Akt signaling by post-infarct ventricular remodeling is compensated by an ERK-mediated pathway. Reviewed

Miki T, Miura T, Tanno M, Nishihara M, Naitoh K, Sato T, Takahashi A, Shimamoto K

Basic research in cardiology   102   163 - 170   2007.3

Nucleocytoplasmic shuttling of the NAD+-dependent histone deacetylase SIRT1. Reviewed

Tanno M, Sakamoto J, Miura T, Shimamoto K, Horio Y

The Journal of biological chemistry   282   6823 - 6832   2007.3

Activation of ERK and suppression of calcineurin are interacting mechanisms of cardioprotection afforded by delta-opioid receptor activation. Reviewed

Ikeda Y, Miura T, Sakamoto J, Miki T, Tanno M, Kobayashi H, Ohori K, Takahashi A, Shimamoto K

Basic research in cardiology   101   418 - 426   2006.9

Erythropoietin affords additional cardioprotection to preconditioned hearts by enhanced phosphorylation of glycogen synthase kinase-3 beta. Reviewed

Nishihara M, Miura T, Miki T, Sakamoto J, Tanno M, Kobayashi H, Ikeda Y, Ohori K, Takahashi A, Shimamoto K

American journal of physiology. Heart and circulatory physiology   291   H748 - 55   2006.8

Alteration in erythropoietin-induced cardioprotective signaling by postinfarct ventricular remodeling. Reviewed

Miki T, Miura T, Yano T, Takahashi A, Sakamoto J, Tanno M, Kobayashi H, Ikeda Y, Nishihara M, Naitoh K, Ohori K, Shimamoto K

The Journal of pharmacology and experimental therapeutics   317   68 - 75   2006.4

Time window for the contribution of the delta-opioid receptor to cardioprotection by ischemic preconditioning in the rat heart Reviewed

A Tsuchida, T Miura, M Tanno, Y Nozawa, H Kita, K Shimamoto

CARDIOVASCULAR DRUGS AND THERAPY   12 ( 4 )   365 - 373   1998.9

Clinical impact of nuclear MLKL phosphorylation in nonischemic dilated cardiomyopathy

FUJITA Yugo, YANO Toshiyuki, NISHIKAWA Ryo, NAGANO Nobutaka, KAMIYAMA Naoyuki, FUJITO Takefumi, MOCHIZUKI Atsushi, KOYAMA Masayuki, KOUZU Hidemichi, MURANAKA Atsuko, NAGAHARA Daigo, KUNO Atsushi, TANNO Masaya, MIURA Tetsuji

日本心不全学会学術集会プログラム・抄録集   24th (CD-ROM)   2020

Xanthine oxidoreductase-mediated metabolic and functional dysfunction is amplified by upregulated AMP deaminase in diabetic hearts

OSANAMI Arata, IGAKI Yusuke, TANNO Masaya, KOUZU Hidemichi, SATO Tatsuya, KUNO Atsushi, MIURA Tetsuji

日本心不全学会学術集会プログラム・抄録集   24th (CD-ROM)   2020

Longitudinal impact of dapagliflozin treatment on ventricular repolarization heterogeneity in patients with type 2 diabetes

Tatsuya Sato, Takayuki Miki, Shinya Furukawa, Bunzo Matsuura, Yoichi Hiasa, Hirofumi Ohnishi, Masaya Tanno, Tetsuji Miura

Journal of Diabetes Investigation   10 ( 6 )   1593 - 1594   2019.11

2型糖尿病ラットにおけるxanthine oxidase阻害は圧過負荷誘発拡張機能障害を減弱させる(Inhibition of Xanthine Oxidase in Type 2 Diabetic Rats Ameliorates Pressure Overload-induced Diastolic Dysfunction)

井垣 勇祐, 丹野 雅也, 舘越 勇輝, 木村 幸滋, 佐藤 達也, 神津 英至, 矢野 俊之, 久野 篤史, 三木 隆幸, 三浦 哲嗣

日本循環器学会学術集会抄録集   83回   OJ40 - 9   2019.3

拡張型心筋症においてnecroptosisの内因性阻害因子caspase-8値の低下は左室拡大と関連する(Reduced Level of Caspase-8, an Endogenous Inhibitor of Necroptosis, is Associated with Left Ventricular Enlargement in Dilated Cardiomyopathy)

藤田 雄吾, 矢野 俊之, 永野 伸卓, 神山 直之, 藤戸 健史, 望月 敦史, 小山 雅之, 神津 英至, 村中 敦子, 永原 大五, 丹野 雅也, 三木 隆幸, 三浦 哲嗣

日本循環器学会学術集会抄録集   83回   OJ19 - 7   2019.3

Distinct expressions of caspase-8 and phospho-MLKL, necroptosis regulatory proteins, in nonischemic dilated cardiomyopathy

FUJITA Yugo, FUJITA Yugo, YANO Toshiyuki, NAGANO Nobutaka, NISHIKAWA Ryo, KAMIYAMA Naoyuki, FUJITO Takefumi, MOCHIZUKI Atsushi, KOYAMA Masayuki, KOUZU Hidemichi, MURANAKA Atsuko, NAGAHARA Daigo, TANNO Masaya, MIKI Takayuki, MIURA Tetsuji

日本心不全学会学術集会プログラム・抄録集   23rd   2019

mTORC1 inhibition attenuates necroptosis through RIP1 inhibition-mediated TFEB activation

Abe Koki, Yano Toshiyuki, Tanno Masaya, Miki Takayuki, Kuno Atsushi, Kuno Atsushi, Sato Tatsuya, Sato Tatsuya, Kouzu Hidemichi, Nakata Kei, Ohwada Wataru, Kimura Yukishige, Sugawara Hirohito, Shibata Satoru, Igaki Yusuke, Ino Shoya, Miura Tetsuji

Biochimica et Biophysica Acta   1865 ( 12 )   2019

糖尿病の外来診療における慢性合併症評価実態の検討

伊野祥哉, 中田圭, 東浦幸村, 佐藤達也, 矢野俊之, 古橋眞人, 丹野雅也, 三木隆幸, 斎藤重幸, 三浦哲嗣

糖尿病(Web)   62 ( Suppl )   2019

Novel microRNA-mediated Regulation of AMP Deaminase, a Key Player in Diabetic Cardiomyopathy

TANNO Masaya, TATEKOSHI Yuki, KOUZU Hidemichi, KUNO Atsushi, YANO Toshiyuki, MIKI Takayuki, MIURA Tetsuji

日本循環器学会学術集会(Web)   83rd   2019

Impact of activation of necroptosis signaling on mitochondrial dynamics in cardiomyocytes

YANO Toshiyuki, ONG Sang-Bing, SATO Tatsuya, KOUZU Hidemichi, KUNO Atsushi, TANNO Masaya, MIKI Takayuki, MIURA Tetsuji

日本心血管内分泌代謝学会学術総会プログラム及び抄録集   23rd   2019

AMP deaminase: a promising therapeutic target for diabetic cardiomyopathy

TANNO Masaya, TATEKOSHI Yuki, KOUZU Hidemichi, MIURA Tetsuji

日本心不全学会学術集会プログラム・抄録集   22nd   2018

冠疾患危険因子の管理目標達成率が冠動脈病変に与える影響

中田圭, 村上直人, 青山ちひろ, 鎌田祐介, 能登貴弘, 国分宜明, 丹野雅也, 三木隆幸, 三浦哲嗣

糖尿病(Web)   61 ( Suppl )   2018

Dysregulation of miR-301b Contributes to Diabetic Cardiomyopathy via Upregulation of AMP Deaminase in the Vicinity of the Sarcoplasmic Reticulum

Yuki Tatekoshi, Masaya Tanno, Takayuki Miki, Atsushi Kuno, Toshiyuki Yano, Wataru Ohwada, Koki Abe, Yusuke Igaki, Yugo Fujita, Tetsuji Miura

CIRCULATION   136   2017.11

Empagliflozin, an SGLT2 inhibitor, improves survival after myocardial infarction in diabetic rats by up-regulating anti-oxidative stress proteins

H. Oshima, M. Mizuno, T. Miki, A. Kuno, K. Nakata, Y. Kimura, T. Yano, M. Tanno, T. Miura

DIABETOLOGIA   60   S32 - S32   2017.9

An SGLT-2 inhibitor reverses impaired ventricular repolarisation in patients with type 2 diabetes

T. Sato, T. Miki, H. Ohnishi, T. Yamashita, A. Takada, T. Yano, M. Tanno, A. Tsuchida, T. Miura

DIABETOLOGIA   60   S424 - S425   2017.9

【高齢者の循環器診療の加齢変化の課題-ここが知りたい-】高齢者糖尿病治療における高血圧 高血圧治療ガイドライン2014の活用

大和田 渉, 丹野 雅也

臨床医のための循環器診療   ( 26 )   29 - 31   2017.3

急性心不全患者へのバソプレシンV2受容体遮断薬長期投与の効果:BOREAS-ADHFレジストリ研究

長南新太, 丹野雅也, 能登貴弘, 永野伸卓, 神津英至, 村上直人, 西田絢一, 国分宣明, 三浦哲嗣

日本循環器学会北海道地方会(Web)   118th   2017

Tristetraprolin-mediated regulation of Rieske, a mitochondrial complex III protein, protects the heart against iron deficiency

SATO Tatsuya, TANNO Masaya, YANO Toshiyuki, MIKI Takayuki, KUNO Atsushi, KOUZU Hidemichi, ARDEHALI Hossein, MIURA Tetsuji

日本心不全学会学術集会プログラム・抄録集   21st   2017

多腺性自己免疫症候群3A型に房室ブロックを合併した一例:抗Ro/SS-A抗体との関連

中田圭, 矢野俊之, 大島洸人, 古橋眞人, 丹野雅也, 斎藤重幸, 三木隆幸, 三浦哲嗣

糖尿病(Web)   60 ( Suppl )   2017

ROS-Induced Mitochondrial Translocation of Phosphatases Cancels Cell-Protective Signals Activated by Phosphorylation of Mitochondrial Protective Kinases

Wataru Ohwada, Masaya Tanno, Toshiyuki Yano, Atsushi Kuno, Takayuki Miki, Satoko Ishikawa, Yuki Tatekoshi, Koki Abe, Kouhei Ohno, Masashi Mizuno, Kei Nakata, Tetsuji Miura

CIRCULATION   134   2016.11

The Role of AMP Deaminase in Diabetic Cardiomyopathy and Its Regulatory Mechanisms: A Potential Novel Therapeutic Target

Masaya Tanno, Hidemichi Kouzu, Yuki Tatekoshi, Tetsuji Miura

JOURNAL OF CARDIAC FAILURE   22 ( 9 )   S161 - S161   2016.9

Aberrant mTORC1 Activation in Cardiomyocytes: A Novel Prognostic Marker and Possible Therapeutic Target in Nonischemic Dilated Cardiomyopathy

Toshiyuki Yano, Masayuki Koyama, Daigo Nagahara, Atsushi Mochizuki, Takefumi Fujito, Masaya Tanno, Takayulci Miki, Tetsuji Miura

JOURNAL OF CARDIAC FAILURE   22 ( 9 )   S174 - S174   2016.9

Sequestration of p62 by RIP1 promotes necroptosis through suppression of autophagic flux in cardiomyocytes; a novel cross-talk between autophagy and necroptosis

T. Yano, M. Ogasawara, T. Miki, M. Tanno, A. Kuno, K. Ohno, K. Nishizawa, W. Owada, M. Mizuno, H. Sugawara, Y. Takekoshi, K. Nakata, S. Ishikawa, T. Miura

EUROPEAN HEART JOURNAL   37   307 - 307   2016.8

Upregulation of AMP deaminase activity in diabetic hearts by decreased interaction with phosphoglucomutase-1 and depletion of fructose 1,6-diphosphate: a novel mechanism for diabetic cardiomyopathy

Y. Tatekoshi, M. Tanno, H. Kouzu, T. Miki, A. Kuno, S. Ishikawa, T. Yano, W. Ohwada, K. Ohno, M. Mizuno, K. Nishizawa, K. Nakata, T. Miura

EUROPEAN HEART JOURNAL   37   1037 - 1038   2016.8

Restoration of the intra-mitochondrial interplay between protective signals and malate-aspartate shuttle by continuous erythropoietin receptor activation prevents CKD-induced infarct size enlargement

K. Nishizawa, T. Yano, T. Miki, M. Tanno, A. Kuno, T. Tobisawa, M. Ogasawara, S. Muratsubaki, K. Ohno, M. Mizuno, W. Ohwada, S. Ishikawa, T. Miura

EUROPEAN HEART JOURNAL   37   522 - 523   2016.8

Excessive ROS production in mitochondria switches off protective mitochondrial kinase signaling

M. Tanno, W. Ohwada, T. Yano, T. Miki, A. Kuno, S. Ishikawa, Y. Tatekoshi, K. Nishizawa, M. Mizuno, T. Miura

CARDIOVASCULAR RESEARCH   111   S1 - S1   2016.7

Ischemic conditioning : pre-, post-, and remote-conditioning (特集 わが国の循環器診療pros・cons : 2016)

丹野 雅也, 三浦 哲嗣

循環器内科 = Cardioangiology   79 ( 6 )   522 - 527   2016.6

睡眠呼吸障害が血糖変動に与える影響の検討

中田圭, 丹野雅也, 矢野俊之, 小笠原淳, 赤坂憲, 古橋眞人, 三木隆幸, 三浦哲嗣

糖尿病(Web)   59 ( Suppl )   2016

Increased activity of AMP deaminase in the vicinity of sarcoplasmic reticulum: a novel mechanism of diabetic cardiomyopathy

TATEKOSHI Yuki, TANNO Masaya, KOUZU Hidemichi, YANO Toshiyuki, KUNO Atsushi, ISHIKAWA Satoko, MIKI Takayuki, MIURA Tetsuji

日本心血管内分泌代謝学会学術総会プログラム及び抄録集   20th   2016

Intramolecular Inhibition of Ser473 Phosphorylation by Up-regulated Thr308 Phosphorylation in Akt Contributes to Enlargement of Infarct Size by Chronic Renal Failure

Toshiyuki Tobisawa, Toshiyuki Yano, Takayuki Miki, Masaya Tanno, Atushi Kuno, Hidemichi Kouzu, Makoto Ogasawara, Shingo Muratsubaki, Kohei Ohno, Keitaro Nishizawa, Masashi Mizuno, Wataru Ohwada, Satoko Ishikawa, Tetsuji Miura

CIRCULATION   132   2015.11

Regulation of Mitochondrial Functions by Sirtuin Proteins in Heart Failure

Masaya Tanno, Atsushi Kuno, Yoshiyuki Horio, Tetsuji Miura

JOURNAL OF CARDIAC FAILURE   21 ( 10 )   S158 - S159   2015.10

Enlargement of Infarct Size by CKD is Preventable by Consistent Activation of the Erythropoietin Receptor

Keitaro Nishizawa, Toshiyuki Yano, Takayuki Miki, Masaya Tanno, Atsushi Kuno, Hidemichi Kouzu, Toshiyuki Tobisawa, Tetsuji Miura

JOURNAL OF CARDIAC FAILURE   21 ( 10 )   S180 - S180   2015.10

Dysregulation of two phosphorylation sites in Akt, Thr308 and Ser473, upon reperfusion mediates enlargement of myocardial infarct size by chronic renal failure

T. Tobisawa, T. Yano, T. Miki, A. Kuno, M. Tanno, H. Kouzu, M. Ogasawara, S. Muratsubaki, K. Ohno, T. Miura

EUROPEAN HEART JOURNAL   36   170 - 170   2015.8

Predictors for atrial fibrillation in patients with coronary artery disease: a cross-sectional analysis of BOREAS registry data

N. Kokubu, H. Akasaka, J. Nishida, N. Nagano, N. Murakami, S. Muratsubaki, M. Tanno, A. Hashimoto, T. Miki, T. Miura

EUROPEAN HEART JOURNAL   36   905 - 905   2015.8

Continuous erythropoietin receptor activation reverses increased myocardial susceptibility to ischemia/reperfusion injury in chronic renal failure

K. Nishizawa, T. Yano, T. Miki, M. Tanno, A. Kuno, H. Kouzu, T. Tobisawa, M. Mizuno, H. Sugawara, T. Miura

EUROPEAN HEART JOURNAL   36   378 - 378   2015.8

老化と心血管疾患(第4回)心疾患発症における長寿遺伝子の役割

丹野 雅也, 三浦 哲嗣

Anti-aging science : 脳心血管抗加齢研究会機関誌   7 ( 1 )   44 - 48   2015.3

心不全と糖尿病が,睡眠呼吸障害と血糖変動の関連へ与える影響

藤田雄吾, 中田圭, 丹野雅也, 鈴木洋平, 長南新太, 舘越勇輝, 能登貴弘, 瀬野結, 三木隆幸, 三浦哲嗣

日本循環器学会北海道地方会(Web)   114th   2015

多発脳梗塞を契機に診断された,特発性好酸球増加症候群にLoefller心内膜心筋炎を合併した一例

大岩修太郎, 能登貴弘, 瀬野結, 神津英至, 村中敦子, 矢野俊之, 丹野雅也, 三浦哲嗣

日本循環器学会北海道地方会(Web)   114th   2015

Dysregulation of intramolecular interplay between two phosphorylation sites in Akt contributes to enlargement of infarct size by chronic renal failure

TOBISAWA Toshiyuki, YANO Toshiyuki, MIKI Takayuki, TANNO Masaya, KUNO Atsushi, KOUZU Hidemichi, OGASAWARA Makoto, MIURA Tetsuji

日本血管生物医学会学術集会プログラム・抄録集   23rd   2015

Disruption of mTORC2 Integrity Underlies Increased Myocardial Susceptibility to Ischemia/reperfusion Injury in Chronic Renal Failure

Toshiyuki Tobisawa, Toshiyuki Yano, Takayuki Miki, Masaya Tanno, Atsushi Kuno, Hidemichi Kouzu, Hiromichi Murase, Makoto Ogasawara, Shingo Muratsubaki, Masashi Mizuno, Keitaro Nishizawa, Satoko Ishikawa, Hideaki Yoshida, Tetsuji Miura

CIRCULATION   130   2014.11

Accumulation of P62 by Dysregulation of Autophagy Induces Rip1-dependent Necroptosis in Cardiomyocytes: a Novel Interplay Between Autophagy and Necroptosis

Makoto Ogasawara, Toshiyuki Yano, Takayuki Miki, Masaya Tanno, Atsushi Kuno, Hidemichi Kouzu, Hiromichi Murase, Toshiyuki Tobisawa, Shingo Muratsubaki, Keitaro Nishizawa, Masashi Mizuno, Satoko Ishikawa, Tetsuji Miura

CIRCULATION   130   2014.11

Activation of mTORC1 in Cardiomyocyte is Associated with Fibrosis and Cardiomyocyte Loss in Heart Failure with Reduced Ejection Fraction

Toshiyuki Yano, Shinya Shimoshige, Atsushi Mochizuki, Takefumi Fujito, Atsuko Muranaka, Satoshi Yuda, Masaya Tanno, Takayuki Miki, Akiyoshi Hashimoto, Kazufumi Tsuchihashi, Tetsuji Miura

CIRCULATION   130   2014.11

Clinical Significance of mTORC1 Activation in Cardiomyocytes in Failing Hearts with Reduced Ejection Fraction

Toshiyuki Yano, Shinya Shimoshige, Atsushi Mochizuki, Takefumi Fujito, Atsuko Muranaka, Satoshi Yuda, Masaya Tanno, Takayuki Miki, Akiyoshi Hashimoto, Tetsuji Miura

JOURNAL OF CARDIAC FAILURE   20 ( 10 )   S188 - S188   2014.10

Insufficient ATP supply due to excessive degradation of adenine nucleotides by AMP deaminase underlies afterload-induced diastolic dysfunction in the type 2 diabetic heart

H. Kouzu, T. Miki, M. Tanno, A. Kuno, T. Yano, H. Murase, T. Tobisawa, M. Ogasawara, S. Muratsubaki, T. Miura

EUROPEAN HEART JOURNAL   35   327 - 327   2014.9

リバース・リモデリングへの挑戦 リバース・リモデリングの分子標的 基礎から臨床へ

矢野 俊之, 小山 雅之, 望月 敦史, 神津 英至, 村中 敦子, 下重 晋也, 丹野 雅也, 湯田 聡, 橋本 暁佳, 三木 隆幸, 三浦 哲嗣

日本心臓病学会学術集会抄録   62回   JS8 - 5   2014.9

Inhibition of DPP-4 restores myocardial autophagic flux and reduces mortality after myocardial infarction in diabetic rats

H. Murase, A. Kuno, T. Miki, M. Tanno, T. Yano, H. Kouzu, T. Tobisawa, M. Ogasawara, S. Ishikawa, T. Miura

EUROPEAN HEART JOURNAL   35   443 - 444   2014.9

Mitochondrial translocation of GSK-3beta, a trigger of mitochondrial permeability transition, is mediated by its N-terminal domain and promoted by interaction with VDAC2.

M. Tanno, T. Miura, T. Miki, A. Kuno, S. Ishikawa, T. Yano, H. Kouzu

CARDIOVASCULAR RESEARCH   103   2014.7

A novel interplay between RIP1-dependent necroptosis and autophagy in cardiomyocytes.

OGASAWARA Makoto, YANO Toshiyuki, MIKI Takayuki, TANNO Masaya, KUNO Atsushi, KOUZU Hidemichi, ISHIKAWA Satoko, MIURA Tetsuji

International Society for Heart Research Annual Meeting of the Japanese Section. Program and Abstracts   31st   2014

DPP-4 inhibition restores myocardial autophagic flux through attenuation of Bcl2-beclin-1 interaction and improves survival after myocardial infarction in diabetic rats.

MURASE Hiromichi, KUNO Atsushi, MIKI Takayuki, TANNO Masaya, YANO Toshiyuki, KOUZU Hidemichi, ISHIKAWA Satoko, MIURA Tetsuji

International Society for Heart Research Annual Meeting of the Japanese Section. Program and Abstracts   31st   2014

Activation of the Glucagon-Like Peptide-1 Receptor Restores Myocardial Autophagic Flux and Reduces Mortality After Myocardial Infarction in Diabetic Rats

Hiromichi Murase, Atsushi Kuno, Takayuki Miki, Masaya Tanno, Toshiyuki Yano, Hidemichi Kouzu, Toshiyuki Tobisawa, Makoto Ogasawara, Satoko Ishikawa, Tetsuji Miura

CIRCULATION   128 ( 22 )   2013.11

The Role of mTORC2 and Ribosomal Protein S6 in Cardioprotective Signaling

Toshiyuki Yano, Marcella Ferlito, Toshiyuki Tobisawa, Atsushi Ogasawara, Hiromichi Murase, Atsushi Kuno, Masaya Tanno, Takayuki Miki, Charles Steenbergen, Tetsuji Miura

JOURNAL OF CARDIAC FAILURE   19 ( 10 )   S138 - S138   2013.10

Type 2 diabetes induces ventricular electrical remodeling with a transmural gradient

T. Tobisawa, T. Sato, S. Yuda, T. Miki, M. Tanno, A. Kuno, T. Kobayashi, H. Akasaka, N. Tohse, T. Miura

EUROPEAN HEART JOURNAL   34   926 - 926   2013.8

Mechanisms Underlying Mitochondrial Translocation Of GSK-3 beta, A Crucial Inducer Of Mitochondrial Permeability Transition: GSK-3 beta Activity, Interaction With VDAC2 And A Mitochondrial Targeting Sequence

Masaya Tanno, Atsushi Kuno, Satoko Ishikawa, Makoto Ogasawara, Toshiyuki Tobisawa, Hiromichi Murase, Tatsuya Sato, Hidemichi Kouzu, Takayuki Miki, Tetsuji Miura

CIRCULATION RESEARCH   113 ( 4 )   2013.8

Mechanisms of atherosclerosis promoted by hypertension

245 ( 13 )   1148 - 1152   2013.6

酸化ストレスによるミトコンドリア透過性遷移に対するニコランジルの効果

須永 大介, 石川 聡子, 神津 英至, 久野 篤史, 丹野 雅也, 三木 隆幸, 三浦 哲嗣

Therapeutic Research   34 ( 3 )   296,304 - 299,304   2013.3

Reversal of metabolic shift in post-infarct-remodelled hearts: possible novel therapeutic approach

Masaya Tanno, Atsushi Kuno

CARDIOVASCULAR RESEARCH   97 ( 2 )   195 - 196   2013.2

急激な血糖悪化を契機に偶然発見され、多腺性内分泌腫瘍症1型が疑われた1例

菅原 浩仁, 小笠原 惇, 伊藤 孝仁, 田中 希尚, 古橋 眞人, 下重 晋也, 丹野 雅也, 三浦 哲嗣

糖尿病   56 ( 1 )   41 - 41   2013.1

Insufficient ATP Supply due to Excessive Degradation of Adenine Nucleotides Underlies Afterload-induced Diastolic Dysfunction in Type 2 Diabetic Heart

KOUZU Hidemichi, MIKI Takayuki, TANNO Masaya, KUNO Atsushi, YANO Toshiyuki, MURASE Hiromichi, TOBISAWA Toshiyuki, OGASAWARA Makoto, MIURA Etsuji

Journal of Cardiac Failure   19 ( 10 Supplement 1 )   2013

Mechanisms of mPTP re-closure by activation of the mitochondrical ATP-sensitive K⁺ channel: suppression of GSK-3β-Rieske interaction and ROS production after oxidative stress

SUNAGA Daisuke, TANNO Masaya, ISHIKAWA Satoko, KUNO Atsushi, SATO Tatsuya, KOUZU Hidemichi, MIKI Takayuki, MIURA Tetsuji

International Society for Heart Research Annual Meeting of the Japanese Section. Program and Abstracts   30th   2013

Type 2 diabetes induces subendocardium-predominant reduction of transient outward K⁺ current via downregulation of Kv4.2 and KChIP2.

SATO Tatsuya, KOBAYASHI Takeshi, KUNO Atsushi, MURASE Hiromichi, ISHIKAWA Satoko, KOUZU Hidemichi, TANNO Masaya, MIKI Takayuki, MIURA Tetsuji, TOHSE Noritsugu

International Society for Heart Research Annual Meeting of the Japanese Section. Program and Abstracts   30th   2013

Titin-isoform Shift May Underlie Distinct Ventricular Responses to Pressure and Volume Overloads in Type 2 Diabetic Heart

Hidemichi Kouzu, Atsushi Kuno, Takayuki Miki, Masaya Tanno, Takahito Itoh, Tatsuya Sato, Daisuke Sunaga, Hiromichi Murase, Tetsuji Miura

CIRCULATION   126 ( 21 )   2012.11

Determinants of Plasma BNP Level in Apparently Healthy Subjects: A Cross-sectional Analysis in the Tanno-Sobetsu Study

Hiroshi Akasaka, Hirofumi Ohnishi, Masaya Tanno, Tetsuji Miura

JOURNAL OF CARDIAC FAILURE   18 ( 10 )   S154 - S154   2012.10

Modified interaction of inorganic phosphate carrier with cyclophilin D underlies impaired response of diabetic heart to cardioprotection

T. Itoh, T. Miki, M. Tanno, A. Kuno, H. Kouzu, T. Sato, D. Sunaga, H. Murase, S. Ishikawa, T. Miura

EUROPEAN HEART JOURNAL   33   109 - 109   2012.8

Resveratrol, a SIRT1 activator, prevents cardiomyopathy in dystrophin-deficient mice by down-regulation of p300

A. Kuno, M. Tanno, T. Miki, S. Ishikawa, Y. Horio, T. Miura

EUROPEAN HEART JOURNAL   33   803 - 803   2012.8

Transient Outward K+ Current (I-To) is Reduced Especially in the Suben-docardium via Downregulation of Kv4.2 and KChIP2 Gene Expression in Obese Type2 Diabetic Rat Hearts

Tatsuya Sato, Takeshi Kobayashi, Atsushi Kuno, Takayuki Miki, Masaya Tanno, Tetsuji Miura, Noritsugu Tohse

BIOPHYSICAL JOURNAL   102 ( 3 )   339A - 340A   2012.1

SIRT1 activation by resveratrol ameliorates dystrophic muscle pathology in mdx mice

Yusuke Hori, Atsushi Kuno, Ryusuke Hosoda, Masaya Tanno, Tetsuji Miura, Kazuaki Shimamoto, Yoshiyuki Horio

JOURNAL OF PHARMACOLOGICAL SCIENCES   118   72P - 72P   2012

Increased Interaction of Inorganic Phosphate Carrier with Cyclophilin D Underlies Impaired Cardioprotection in Diabetic Heart

ITOH Takahito, MIKI Takayuki, TANNO Masaya, KUNO Atsushi, KOUZU Hidemichi, SATO Tatsuya, SUNAGA Daisuke, MURASE Hiromichi, ISHIKAWA Satoko, MIURA Tetsuji

International Society for Heart Research Annual Meeting of the Japanese Section. Program and Abstracts   29th   2012

UPR In Endoplasmic Reticulum vs. UPR In Mitochondria In Diabetic Myocardium: Which Is Responsible For Deficient Regulation Of Mitochondrial Permeability Transition Pores?

Takahito Itoh, Hidemichi Kouzu, Takayuki Miki, Masaya Tanno, Atsushi Kuno, Tatsuya Sato, Daisuke Sunaga, Satoko Ishikawa, Tetsuji Miura

CIRCULATION   124 ( 21 )   2011.11

Long-Term Treatment with the SIRT1 Activator Resveratrol Ameliorates Cardiomyopathy in Dystrophin-Deficient Mice

Atsushi Kuno, Yusuke Hori, Masaya Tanno, Hidemichi Kouzu, Takahito Itoh, Daisuke Sunaga, Yoshiyuki Horio, Tetsuji Miura

CIRCULATION   124 ( 21 )   2011.11

GSK-3 beta Translocates to Mitochondria by Oxidant Stress in a Kinase Activity-Dependent Manner and Contributes to Lethal ROS Production

Masaya Tanno, Takayuki Miki, Atsushi Kuno, Hidemichi Kouzu, Takahito Itoh, Tatsuya Sato, Satoko Ishikawa, Daisuke Sunaga, Tetsuji Miura

CIRCULATION   124 ( 21 )   2011.11

Treatment with a Sirt1 Activator Resveratrol Prevents Cardiomyopathy in Dystrophin-Deficient Mice

Atsushi Kuno, Yusuke Hori, Tatsuya Sato, Hidemichi Kouzu, Masaya Tanno, Takayuki Miki, Yoshiyuki Horio, Tetsuji Miura

JOURNAL OF CARDIAC FAILURE   17 ( 9 )   S149 - S149   2011.9

肥満2型糖尿病ラットの心臓における左室収縮および活動電位の特徴(Characteristics of Left Ventricular Contractility and Action Potential in Heart of Obese Type2 Diabetes Rats)

Sato Tatsuya, Takada Akifumi, Hotta Hiroyuki, Miki Takayuki, Tanno Masaya, Kobayashi Takeshi, Maeda Sachiko, Ichise Nobutoshi, Kuno Atsushi, Kohzu Hidemichi, Itoh Takahito, Sunaga Daisuke, Ishikawa Satoko, Miura Tetsuji, Tohse Noritsugu

Circulation Journal   75 ( Suppl.I )   3 - 3   2011.3

Dysregulation of the mitochondrial permeability transition pore by increased UPRs in the ER and mitochondria underlies loss of protection in diabetic hearts.

ITOH Takahito, KOUZU Hidemichi, MIKI Takayuki, TANNO Masaya, KUNO Atsushi, SATO Tatsuya, SUNAGA Daisuke, ISHIKAWA Satoko, MIURA Tetsuji

International Society for Heart Research Annual Meeting of the Japanese Section. Program and Abstracts   28th   2011

Connexin-43 Contributes to Transmission of MitoK(ATP) Channel-Derived Redox Signal to Akt-GSK-3 beta Pathway in Cardiomyocyte Protection Afforded by G-protein Coupled Receptors

Satoko Ishikawa, Atsushi Kuno, Takayuki Miki, Masaya Tanno, Toshiyuki Yano, Hidemichi Kouzu, Tatsuya Sato, Daisuke Sunaga, Tetsuji Miura

CIRCULATION   122 ( 21 )   2010.11

Activation of Sirt1 Suppresses Hypertrophic Response of Cardiomyocytes by Inhibition of H3K9 Acetylation via Proteasome-mediated p300 Degradation.

Atsushi Kuno, Masaya Tanno, Satoko Ishikawa, Yoshiyuki Horio, Tetsuji Miura

CIRCULATION   122 ( 21 )   2010.11

Increased ER Stress is a Fundamental Mechanism for Impairment of Cardioprotective Signaling in Type 2 Diabetes

Hidemichi Kouzu, Takahito Itoh, Takayuki Miki, Masaya Tanno, Toshiyuki Yano, Tatsuya Sato, Akifumi Takada, Daisuke Sunaga, Tetsuji Miura

CIRCULATION   122 ( 21 )   2010.11

Ventricular Dysfunction and Blunted Response to Adrenergic Stimulation in Obese Type 2 Diabetes Predispose to Fatal Heart Failure After Infarction: Possible Involvement of MicroRNA-1 Down-Regulation

Akifumi Takada, Takayuki Miki, Masaya Tanno, Hiromu Suzuki, Toshiyuki Yano, Atushi Kuno, Takahito Itoh, Tatsuya Sato, Tetsuji Miura

CIRCULATION   122 ( 21 )   2010.11

Apparently Slight Ventricular Dysfunction Predisposes Obese Type 2 Diabetic Rats to High Mortality After Myocardial Infarction

Hidemichi Kouzu, Akifumi Takada, Takayuki Miki, Masaya Tanno, Toshiyuki Yano, Atsushi Kuno, Takahito Itoh, Tatsuya Satoh, Tetsuji Miura

JOURNAL OF CARDIAC FAILURE   16 ( 9 )   S169 - S169   2010.9

Activation of SIRT1 modifies histone acetylation/methylation and attenuates cardiomyocyte hypertrophy

Atsushi Kuno, Masaya Tanno, Yoshiyuki Horio

JOURNAL OF PHARMACOLOGICAL SCIENCES   112   200P - 200P   2010

ROS-mediated Dysregulation of Mitochondrial Permeability Transition Pore Underlies Increased Susceptibility of Hypertensive Hypertrophied Hearts to Ischemia/reperfusion Injury

Toshiyuki Yano, Tetsuji Miura, Takayuki Miki, Masaya Tanno, Atsushi Kuno, Takahito Itoh, Akifumi Takada, Tatsuya Satoh, Kazuaki Shimamoto

CIRCULATION   120 ( 18 )   S784 - S784   2009.11

The SIRT1 Activator Resveratrol Suppresses Cardiomyocyte Hypertrophy by Promoting Histone H3 Lys9 Deacetylation and Tri-methylation

Atsushi Kuno, Masaya Tanno, Toshiyuku Yano, Akifumi Takada, Satoko Ishikawa, Tetsuji Miura, Yoshiyuki Horio, Kazuaki Shimamoto

CIRCULATION   120 ( 18 )   S617 - S617   2009.11

Activation of histone/protein deacetylase SIRT1 by resveratrol induces MnSOD up-regulation via FOXO3a and improves survival of heart failure animals

A. Kuno, M. Tanno, T. Miura, Y. Horio, K. Shimamoto

EUROPEAN HEART JOURNAL   30   421 - 421   2009.9

Enhanced ANT-cyclophilin-D interaction underlies reduced anti-infarct tolerance and loss of protective response to erythropoietin in hypertensive hypertrophied hearts

T. Miki, T. Yano, T. Miura, M. Tanno, K. Shimamoto

EUROPEAN HEART JOURNAL   30   213 - 213   2009.9

Role of GSK-3beta in negative regulation of mitochondrial permeability transition pore by the mitochondrial KATP channel

T. Miura, Y. Terashima, O. Maas, T. Miki, M. Tanno, S. Ishikawa, K. Shimamoto

EUROPEAN HEART JOURNAL   30   212 - 213   2009.9

OE-036 Roles of GSK-3 β in Myocardial Protection Afforded by Activation of the Mitochondrial K_<ATP> Channel(OE06,Myocardial Ischemia-reperfusion (Basic) (IHD),Oral Presentation (English),The 73rd Annual Scientific Meeting of The Japanese Circulation Society)

Terashima Yoshiaki, Miura Tetsuji, Miki Takayuki, Tanno Masaya, Yano Toshiyuki, Hotta Hiroyuki, Ishikawa Satoko, Shimamoto Kazuaki

Circulation journal : official journal of the Japanese Circulation Society   73   183 - 183   2009.3

OE-010 Distinct Roles of PKC ε and p38MAPK in Preconditioning-induced Modulation of Gap Junction Permeability during Ischemia(OE02,ACS/AMI (Basic) (IHD),Oral Presentation (English),The 73rd Annual Scientific Meeting of The Japanese Circulation Society)

Yano Toshiyuki, Miura Tetsuji, Miki Takayuki, Tanno Masaya, Naitoh Kazuyuki, Hotta Hiroyuki, Terashima Yoshiaki, Ito Takahito, Hongo Tamaki, Shimamoto Kazuaki

Circulation journal : official journal of the Japanese Circulation Society   73   176 - 176   2009.3

DPE-012 Activation of SIRT1, a Histone/Protein Deacetylase, by Resveratrol Up-regulates MnSOD and Suppresses the Progression of Heart Failure(DPE02,Heart Failure, Basic (M),Digital Poster Session (English),The 73rd Annual Scientific Meeting of The Japanese Circulation Society)

Tanno Masaya, Kuno Atsushi, Ishikawa Satoko, Miura Tetsuji, Miki Takayuki, Horio Yoshiyuki, Shimamoto Kazuaki

Circulation journal : official journal of the Japanese Circulation Society   73   358 - 359   2009.3

PE-545 Distinct Roles of FOXO Subtypes in SIRT1-mediated Mn-SOD Up-regulation under Oxidative Stress(PE091,Molecular Biology (M),Poster Session (English),The 73rd Annual Scientific Meeting of the Japanese Circulation Society)

Kuno Atsushi, Tanno Masaya, Miura Tetsuji, Horio Yoshiyuki, Shimamoto Kazuaki

Circulation journal : official journal of the Japanese Circulation Society   73   537 - 537   2009.3

FRS-044 ROS-mediated Enhancement of ANT-cyclophilin-D Interaction Underlies Reduced Anti-infarct Tolerance and Lost Response of Cardiomyocytes to Pro-survival Signaling in Hypertrophied Hearts(FRS9,Novel Mechanisms of Myocardial Ischemia (IHD),Featured Research Session (English),The 73rd Annual Scientific Meeting of The Japanese Circulation Society)

Yano Toshiyuki, Miura Tetsuji, Miki Takayuki, Tanno Masaya, Terashima Yoshiaki, Ito Takahito, Ishikawa Satoko, Takada Akifumi, Shimamoto Kazuaki

Circulation journal : official journal of the Japanese Circulation Society   73   147 - 147   2009.3

OE-008 Homodimeric Erythropoietin (EPO) Receptor Provokes More Potent and Distinct Cytoprotective Signaling Compared with Heterodimeric EPO-common-β Subunit Receptor in the Heart(OE02,ACS/AMI (Basic) (IHD),Oral Presentation (English),The 73rd Annual Scientific Meeting of The Japanese Circulation Society)

Satoh Takahiro, Miura Tetsuji, Miki Takayuki, Tanno Masaya, Yano Toshiyuki, Hotta Hiroyuki, Hongo Tamaki, Shimamoto Kazuaki

Circulation journal : official journal of the Japanese Circulation Society   73   175 - 176   2009.3

Activation of SIRT1 by resveratrol prevents progression of heart failure and improves the survival in cardiomyopathic hamsters by upregulating MnSOD

Atsushi Kuno, Masaya Tanno, Yoshiyuki Horio

JOURNAL OF PHARMACOLOGICAL SCIENCES   109   112P - 112P   2009

Resveratrol activates protein deacetylase SIRT1 and prolongs the survival of heart failure animals by up-regulating MnSOD through transactivation of FOXO3a

Atsushi Kuno, Masaya Tanno, Tetsuji Miura, Yoshiyuki Horio, Kazuaki Shimamoto

JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY   45   S19 - S19   2008.10

Activation of a Protein Deacetylase, SIRT1, by Resveratrol Suppresses Progression of Heart Failure and Improves Survival by Up-Regulation of Mn-SOD

Masaya Tanno, Atsushi Kuno, Takayuki Miki, Tetsuji Miura, Yoshiyuki Horio, Kazuaki Shimamoto

CIRCULATION   118 ( 18 )   S388 - S388   2008.10

Rasveratrol, an Activator of Protein Deacetylase SIRT1, Suppresses Oxidative Stress-Induced Call Death by Upregulating MnSOD Expression through Transactivation of FOXO3a

Atsushi Kuno, Masaya Tanno, Tetsuji Miura, Yoshiyuki Horio, Kazuaki Shimamoto

CIRCULATION   118 ( 18 )   S391 - S391   2008.10

Connexin43-dependent And -independent Mechanisms Of Mitochondrial GSK-3 beta Phosphorylation In Protection Of Cardiomyocyte Against Necrosis

Satoko Ishilkawa, Takayuki Miki, Masaya Tanno, Atsushi Kuno, Takahiro Sato, Hiroyuki Hotta, Yoshiaki Terashima, Tetsuji Miura

CIRCULATION   118 ( 18 )   S355 - S355   2008.10

Role of GSK-3 beta modulation in cytoprotective regulation of mitochondrial permeability transition pores by mitochondrial K-ATP channel activation

Yoshiaki Terashima, Tetsuji Miura, Takayuki Miki, Masaya Tanno, Atsushi Kuno, Toshiyuki Yano, Hiroyuki Hotta, Satoko Ishikawa, Kazuaki Shimamoto

JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY   45   S22 - S22   2008.10

ER Stress Contributes to Dysregulation Of GSK-3 beta-mediated Suppression of Mitochondrial Permeability Transition in Diabetic Hearts

Takayuki Miki, Masaya Tanno, Atsushi Kuno, Toshiyuki Yano, Takahiro Sato, Hiroyuki Hotta, Satoko Ishikawa, Tetsuji Miura

CIRCULATION   118 ( 18 )   S290 - S291   2008.10

Jak2-mediated cardioprotective signaling is lost in diabetic hearts by up-regulation of calcineurin and enhanced ER stress by the AT1 receptor

Hiroyuki Hotta, Tetsuji Miura, Takayuki Miki, Masaya Tanno, Toshiyuki Yano, Yoshiaki Terashima, Kazuaki Shimamoto

JOURNAL OF CARDIAC FAILURE   14 ( 7 )   S163 - S163   2008.9

PJ-005 Impairment of Myocardial Response to Erythropoietin-Induced Protection in Hypertensive Hypertrophied Hearts(Acute myocardial infarction, basic(02)(IHD),Poster Session(Japanese),The 72nd Annual Scientific Meeting of the Japanese Circulation Society)

Yano Toshiyuki, Miura Tetsuji, Miki Takayuki, Tanno Masaya, Satoh Takahiro, Terashima Yoshiaki, Ishikawa Satoko, Shimamoto Kazuaki

Circulation journal : official journal of the Japanese Circulation Society   72   511 - 511   2008.3

PE-333 Resveratrol, An Activator of Longevity Protein SIRT1, Suppresses Progression of Heart Failure Through SIRT1-mediated Cardiomyocyte Protection Against Oxidant Stress(Heart failure, basic(03)(M),Poster Session(English),The 72nd Annual Scientific Meeting of the Japanese Circulation Society)

Tanno Masaya, Miura Tetsuji, Miki Takayuki, Yano Toshiyuki, Ohhori Katsuhiko, Horio Yoshiyuki, Shimamoto Kazuaki

Circulation journal : official journal of the Japanese Circulation Society   72   443 - 443   2008.3

PE-222 Alteration of Akt-GSK-3β Signaling by ER Stress Underlies Failure of Erythropoietin to Protect Diabetic Hearts(Myocardial ischemia/reperfusion, basic/clinical(03)(IHD),Poster Session(English),The 72nd Annual Scientific Meeting of the Japanese Circulation Society)

Miki Takayuki, Miura Tetsuji, Tanno Masaya, Yano Toshiyuki, Satoh Takahiro, Hotta Hiroyuki, Terashima Yoshiaki, Simamoto Kazuaki

Circulation journal : official journal of the Japanese Circulation Society   72   415 - 416   2008.3

OE-309 Relationship of the Mitochondrial K_<ATP> Channel and GSK-3β in Enhancement of Myocardial Tolerance against Infarction(Myocardial ischemia/reperfusion, basic/clinical(01)(IHD),Oral Presentation(English),The 72nd Annual Scientific Meeting of the Japanese Circulation Society)

Terashima Yoshiaki, Miura Tetsuji, Miki Takayuki, Tanno Masaya, Yano Toshiyuki, Hotta Hiroyuki, Shimamoto Kazuaki

Circulation journal : official journal of the Japanese Circulation Society   72   258 - 258   2008.3

OJ-104 Connexin-43 Contributes to Pro-survival Akt/GSK-3β signaling And Cardimyocyte Protection in a Receptor-specifit Manner(Cell death, apoptosis/necrosis(M),Oral Presentation(Japanese),The 72nd Annual Scientific Meeting of the Japanese Circulation Society)

Ishikawa Satoko, Miura Tetsuji, Ichikawa Yoshihiko, Tanno Masaya, Ohhori Katsuhiko, Miki Takayuki, Shimamoto Kazuaki

Circulation journal : official journal of the Japanese Circulation Society   72   314 - 314   2008.3

Resveratrol, an activator of longevity protein SIRT1, suppresses progression of heart failure through SIRT1-mediated cardiomyocyte protection against oxidant stress

Atsushi Kuno, Masaya Tanno, Yoshiyuki Horio

JOURNAL OF PHARMACOLOGICAL SCIENCES   106   213P - 213P   2008

NAD-dependent histone deacetylase SIRT1 modulates neuronal differentiation by its nuclear translocation

Shin Hisahara, Susumu Chiba, Hiroyuki Matsumoto, Masaya Tanno, Shun Shimohama, Makoto Sato, Yoshiyuki Horio

JOURNAL OF PHARMACOLOGICAL SCIENCES   106   114P - 114P   2008

Suppression of mitochondrial GSK3 beta activity by its Ser9-phosphorylation contributes to cardiomyocyte protection afforded by erythropoietin against oxidative stress-induced apoptosis

Katsuhiko Ohori, Tetsuji Miura, Masaya Tanno, Takayuki Miki, Takahiro Satoh, Yoshiyuki Horio, Kazuaki Shimamoto

CIRCULATION   116 ( 16 )   116 - 116   2007.10

Modification of Akt/GSK-3 beta signaling and mitochondrial GSK-3 beta by ER stress underlies failure of erythropoietin to protect diabetic hearts

Takayuki Miki, Masaya Tanno, Toshyuki Yano, Takahiro Satoh, Hiroyuki Hotta, Katsuhiko Ohori, Satoko Ishikawa, Tetsuji Miura

CIRCULATION   116 ( 16 )   164 - 164   2007.10

Ser517-phosphorylation of SIRT1 is required for its PI3K/Akt-mediated nuclear translocation and cardiomyocyte protection against oxidant stress in failing hearts

Masaya Tanno, Tetsup Miura, Takayuki Miki, Toshiyuki Yano, Yoshiyuki Horio, Kazuaki Shimamoto

CIRCULATION   116 ( 16 )   168 - 168   2007.10

Nuclear translocation of SIRT1 by PI3K/Akt-mediated phosphorylation affords cytoprotection against oxidant stress in post-MI failing hearts

M. Tanno, T. Miura, T. Miki, T. Yano, K. Shimamoto, Y. Horio

EUROPEAN HEART JOURNAL   28   280 - 280   2007.9

Reduction of ER stress restored insulin sensitivity and myocardial response to erythropoietin induced-protection in diabetic rats

T. Miki, T. Miura, M. Tanno, T. Yano, K. Naitoh, M. Nishihara, T. Satoh, K. Shimamoto

EUROPEAN HEART JOURNAL   28   433 - 433   2007.9

Erythropoietin inhibits cardiomyocyte apoptosis through inactivation of glycogen synthase kinase 3 beta

Katsuhiko Ohori, Tetsuji Miura, Masaya Tanno, Takayuki Miki, Toshiyuki Yano, Yoshiyuki Horio, Kazuaki Shimamoto

JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY   42   S82 - S82   2007.6

PE-443 Role of Glycogen Synthase Kinase-3 β in Cardiomyocyte Protection by Erythropoietin(Heart failure, basic-5, The 71st Annual Scientific Meeting of the Japanese Circulation Society)

Ohori Katsuhiko, Tanno Masaya, Miura Tetsuji, Miki Takayuki, Yano Toshiyuki, Naitoh Kazuyuki, Nishihara Masahiro, Satoh Takahiro, Horio Yoshiyuki, Shimamoto Kazuaki

Circulation journal : official journal of the Japanese Circulation Society   71   435 - 435   2007.3

OE-312 Nuclear Localization of SIRT1, a Novel Mechanism of Cardiomyocyte Protection in Failing Hearts, is Achieved by PI3K/Akt Signaling(Heart failure, basic-1, The 71st Annual Scientific Meeting of the Japanese Circulation Society)

Tanno Masaya, Sakamoto Jun, Miura Tetsuji, Shimamoto Kazuaki, Horio Yoshiyuki

Circulation journal : official journal of the Japanese Circulation Society   71   229 - 229   2007.3

OE-126 Modulation of Mitochondrial Permeability Transition Pore Complex in GSK-3β-mediated Cardiomyocyte Protection(Myocardial ischemia/reperfusion, basic/clinical-1, The 71st Annual Scientific Meeting of the Japanese Circulation Society)

Nishihara Masahiro, Miura Tetsuji, Miki Takayuki, Tanno Masaya, Yano Toshiyuki, Naitoh Kazuyuki, Ohhori Katsuhiko, Shimamoto Kazuaki

Circulation journal : official journal of the Japanese Circulation Society   71   183 - 183   2007.3

PE-067 Relationships between p38MAPK and PKC in Connexin43-mediated Gap Junction Modulation by Ischemic Preconditioning(Myocardial ischemia/reperfusion, basic/clinical-2, The 71st Annual Scientific Meeting of the Japanese Circulation Society)

Naitoh Kazuyuki, Miura Tetsuji, Miki Takayuki, Yano Toshiyuki, Tanno Masaya, Takahashi Akari, Satoh Takahiro, Shimamoto Kazuaki

Circulation journal : official journal of the Japanese Circulation Society   71   341 - 342   2007.3

OE-053 Cardioprotective Signaling Provoked by Erythropoietin is Impaired in Diabetic Myocardium(Acute myocardial infarction, basic-1, The 71st Annual Scientific Meeting of the Japanese Circulation Society)

Miki Takayuki, Miura Tetsuji, Tanno Masaya, Yano Toshiyuki, Naitoh Kazuyuki, Nishihara Masahiro, Ohhori Katsuhiko, Shimamoto Kazuaki

Circulation journal : official journal of the Japanese Circulation Society   71   164 - 165   2007.3

Transcriptional activation of histone deacetylase SIRT1 by Notch1 signal

Yoshiyuki Horio, Umefumi Iguchi, Takafumi Ninomiya, Haruyuki Tatsumi, Shin Hisahara, Masaya Tanno, Haruo Takemura

JOURNAL OF PHARMACOLOGICAL SCIENCES   103   105P - 105P   2007

Nuclear translocation of SIRT1 upregulates Mn-SOD and promotes cardiomyocyte survival in failing hearts.

Masaya Tanno, Jun Sakamoto, Tetsuji Miura, Kazuaki Shimamoto, Yoshiyuki Horio

JOURNAL OF PHARMACOLOGICAL SCIENCES   103   62P - 62P   2007

Both gap junction-dependent and -independent mechanisms contribute to myocardial salvage by delta-opioid receptor activation

K. Naitoh, T. Miura, M. Nishihara, T. Yano, T. Miki, M. Tanno, K. Ohori, K. Shimamoto

JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY   41 ( 6 )   1055 - 1056   2006.12

GSK-3 beta signaling module in mitochondria leading to myocardial protection against infarction

Masahiro Nishihara, Takayuki Miki, Masaya Tanno, Toshiyuki Yano, Kazuyuki Naitoh, Katsuhiko Ohori, Akari Takahashi, Tetsuji Miura

CIRCULATION   114 ( 18 )   242 - 242   2006.10

Increased nuclear translocation of SIRT1 and MnSOD up-regulation in failing hearts: A novel mechanism of the cardiomyocyte death suppression

Tanno Masaya, Tetsuji Miura, Jun Sakamoto, Kazuaki Shimamoto, Yoshiyuki Horio

JOURNAL OF CARDIAC FAILURE   12 ( 8 )   S159 - S160   2006.10

Contribution of gap junction-dependent and -independent mechanisms to myocardial salvage by delta-opioid receptor activation

Kazuyuki Naitoh, Masahiro Nishihara, Toshiyuki Yano, Takayuki Miki, Masaya Tanno, Katsuhiko Ohori, Akari Takahashi, Tetsuji Miura

CIRCULATION   114 ( 18 )   311 - 311   2006.10

PE-268 Ischemic Preconditioning Modifies Interactions between Connexin43 and Protein Kinases during Myocardial Ischemia(Myocardial ischemia-reperfusion, basic/clinical-4 (IHD) PE45,Poster Session (English),The 70th Anniversary Annual Scientific Meeting of the Japanese Circulation Society)

Naitoh Kazuyuki, Miura Tetsuji, Yano Toshiyuki, Miki Takayuki, Tanno Masaya, Ikeda Yoshihiro, Ohhori Katsuhiko, Shimamoto Kazuaki

Circulation journal : official journal of the Japanese Circulation Society   70   400 - 400   2006.3

OE-026 Activation of ERK and Suppression of Calcineurin are Interacting Mechanisms of Cardioprotection Afforded by δ-opioid Receptor Activation(Myocardial ischemia-reperfusion, basic/clinical-1 (IHD) OE5,Oral Presentation (English),The 70th Anniversary Annual Scientific Meeting of the Japanese Circulation Society)

Ikeda Yoshihiro, Miura Tetsuji, Sakamoto Jun, Tanno Masaya, Yano Toshiyuki, Naitoh Kazuyuki, Satoh Takahiro, Shimamoto Kazuaki

Circulation journal : official journal of the Japanese Circulation Society   70   154 - 155   2006.3

PJ-046 Predictors of Improvement of Exercise Capacity by Nitrates in Experimental Heart Failure(Heart failure, basic-7 (M) PJ8,Poster Session (Japanese),The 70th Anniversary Annual Scientific Meeting of the Japanese Circulation Society)

Takahashi Akari, Miura Tetsuji, Miki Takayuki, Sakamoto Jun, Tanno Masaya, Kobayashi Hironori, Nishihara Masahiro, Shimamoto Kazuaki

Circulation journal : official journal of the Japanese Circulation Society   70   500 - 500   2006.3

PE-601 Molecular Mechanisms of Nucleo-cytoplasmic Shuttling of SIRT1, a Histone Deacetylase, and Its Pathopysicological Roles in Cardiomyocytes(Molecular biology, myocardium-2 (M) PE106,Poster Session (English),The 70th Anniversary Annual Scientific Meeting of the Japanese Circulation Society)

Tanno Masaya, Sakamoto Jun, Miura Tetsuji, Shimamoto Kazuaki, Horio Yoshiyuki

Circulation journal : official journal of the Japanese Circulation Society   70   482 - 483   2006.3

PE-115 Activation of ERK Compensates Disrupted PI3K-Akt Signaling in EPO-induced Cardioprotection of Post-infarct Remodeled Hearts(Acute myocardial infarction, basic-3 (IHD) PE20,Poster Session (English),The 70th Anniversary Annual Scientific Meeting of the Japanese Circulation Society)

Miki Takayuki, Miura Tetsuji, Sakamoto Jun, Tanno Masaya, Naitoh Kazuyuki, Nishihara Masahiro, Takahashi Akari, Shimamoto Kazuaki

Circulation journal : official journal of the Japanese Circulation Society   70   363 - 364   2006.3

The functional significance and mechanisms of nucleo-cytoplasmic shuttling of SIRT1 in failing hearts

M Tanno, J Sakamoto, T Miura, K Shimamoto, Y Horio

JOURNAL OF PHARMACOLOGICAL SCIENCES   100   87P - 87P   2006

Interaction between ERK and PP2B in development of anti-infarct tolerance of the myocardium

Y Ikeda, T Miura, T Miki, M Tanno, T Yano, H Kobayashi, M Nishihara, K Naitoh, K Oohori, K Shimamoto

JOURNAL OF CARDIAC FAILURE   11 ( 9 )   S316 - S316   2005.12

Response of silent information regulator 2 alpha (Sir2 alpha) to severe heart failure and its mechanism of nucleo-cytoplasmic shuttling

M Tanno, J Sakamoto, T Miura, K Shimamoto, Y Horio

JOURNAL OF CARDIAC FAILURE   11 ( 9 )   S279 - S279   2005.12

Effects of ischemic preconditioning on interactions between Connexin43 and protein kinases during myocardial ischemia

K Naito, T Yano, T Miki, J Sakamoto, M Tanno, A Kuno, Y Ikeda, T Miura

CIRCULATION   112 ( 17 )   U284 - U284   2005.10

Antimycin A induced cardioprotection is dependent on pre-ischemic p38-MAPK activation but independent of MKK3

AMN Kabir, XB Cao, DA Gorog, M Tanno, R Bassi, M Bellahcene, RA Quinlan, RJ Davis, RA Flavell, MJ Shattock, MS Marber

JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY   39 ( 4 )   709 - 717   2005.10

Response of silent information regulator 2 alpha (Sir2 alpha) to severe heart failure and its mechanism of nucleo-cytoplasmic shuttling

M Tanno, J Sakamoto, T Miura, K Shimamoto, Y Horio

CIRCULATION   112 ( 17 )   U360 - U360   2005.10

P38-MAPK mediates the early negative inotropic effect of tumour necrosis factor-alpha (TNF). Evidence of synergy between a direct negative inotropic effect and coronary constriction

M Bellahcene, XB Cao, J Layland, M Tanno, AM Kabir, RS Haworth, AM Shah, M Avkiran, MS Marber

HEART   91   A57 - A57   2005.5

Activation of δ-Opioid Receptor Suppresses Myocardial Ischemic Injury by ERK Activation during the Early Phase of Ischemia(Acute Myocardial Infarction, Basic 1 (IHD), The 69th Annual Scientific Meeting of the Japanese Circulation Society)

Ikeda Yoshihiro, Miura Tetsuji, Nakamura Yuichi, Yano Toshiyuki, Tanno Masaya, Sakamoto Jun, Miki Takayuki, Shimamoto Kazuaki

Circulation journal : official journal of the Japanese Circulation Society   69   451 - 451   2005.3

Erythropoietin Reduces Myocardial Ischemic Injury, but not Reperfusion Injury, Through Activation of the Pl3k/Akt Pathway(Myocardial Ischemia-reperfusion, Basic 1 (IHD), The 69th Annual Scientific Meeting of the Japanese Circulation Society)

Kobayashi Hironori, Miura Tetsuji, Miki Takayuki, Sakamoto Jun, Tanno Masaya, Nakamura Yuichi, Ikeda Yoshihiro, Hishihara Masahiro, Shimamoto Kazuaki

Circulation journal : official journal of the Japanese Circulation Society   69   158 - 158   2005.3

Erythropoietin Affords Additional Infarct Size-limiting Effects to Preconditioning through Activation of PI3K-Akt-GSK3β Pathway(Acute Myocardial Infarction, Basic 2 (IHD), The 69th Annual Scientific Meeting of the Japanese Circulation Society)

Nishihara Masahiro, Miura Tetsuji, Miki Takayuki, Nakamura Yuichi, Kobayashi Hironori, Naitoh Kazuyuki, Tanno Masaya, Shimamoto Kazuaki

Circulation journal : official journal of the Japanese Circulation Society   69   373 - 373   2005.3

Sir2 alpha, an NAD-dependent histon deacetylase, is a nucleo-cytoplasmic shuttling protein

M Tanno, J Sakamoto, T Miura, K Shimamoto, Y Horio

JOURNAL OF PHARMACOLOGICAL SCIENCES   97   80P - 80P   2005

p38-MAPK mediates the early negative inotropic effect of tumor necrosis factor-alpha. Evidence of synergy between a direct negative inotropic effect and coronary constriction

M Bellahcene, XB Cao, J Layland, M Tanno, AM Kabir, RS Haworth, M Avkiran, MS Marber

HEART   90 ( 12 )   2004.12

MAPKAPK-2 and serine phospharylation of HSP25/27 and alpha B-crystallin do not increase myocardial resistance to infarction

DA Gorog, M Tanno, S Fisher, Bin Cao, X, M Bellahcene, AM Kabir, RA Quinlan, K Kato, MS Marber

CIRCULATION   110 ( 17 )   67 - 67   2004.10

p38-MAPK mediates the early negative inotropic effect of TNF-alpha in murine hearts. Evidence of synergy between a direct negative inotropic effect and coronary constriction

M Bellahcene, XB Cao, J Layland, M Tanno, DA Gorog, MS Marber

EUROPEAN HEART JOURNAL   25   187 - 187   2004.8

Antimycin A (AA) a mitochondrial free radical generator mediates cardioprotection via p38 mapkinase (p38)

AMN Kabir, XB Cao, DA Gorog, M Tanno, MJ Shattock, MS Marber

JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY   37 ( 1 )   188 - 188   2004.7

P38-MAPK activation during myocardial ischaemia. slayer or redeemer

MS Marber, M Tanno, D Gorog, M Bellahcene

JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY   37 ( 1 )   353 - 354   2004.7

MAPKAPK-2 and serine phosphorylation of HSP25/27 and alpha B-crystallin do not increase myocardial resistance to infarction

DA Gorog, M Tanno, SG Fisher, XB Cao, M Bellahcene, K Dighe, AMN Kabir, RA Quinlan, K Kato, M Gaestel, MS Marber

HEART   90   A24 - A24   2004.5

Antimycin a (AA) mediated cardioprotection is independent of MKK3 but requires PKCe activation

AMN Kabir, XB Cao, M Tanno, R Bassi, MJ Shattock, MS Marber

HEART   90   A24 - A24   2004.5

Inhibition of p38 MAPK activity falls to attenuate contractile dysfunction in a mouse model of low-flow ischemia

DA Gorog, M Tanno, XB Cao, M Bellahcene, R Bassi, AMN Kabir, K Dighe, RA Quinlan, MS Marber

CARDIOVASCULAR RESEARCH   61 ( 1 )   123 - 131   2004.1

Protective role of gap junctions in preconditioning against myocardial infarction

T Miura, Y Ohnuma, A Kuno, M Tanno, Y Ichikawa, Y Nakamura, T Yano, T Miki, J Sakamoto, K Shimamoto

AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY   286 ( 1 )   H214 - H221   2004.1

Tumor necrosis factor-induced protection of the murine heart is independent of p38-MAPK activation

M Tanno, DA Gorog, M Bellahcene, XB Cao, RA Quinlan, MS Marber

JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY   35 ( 12 )   1523 - 1527   2003.12

Role of the MAP kinase pathway in the acute negative isotropic effect of tumour necrosis factor-alpha

M Bellahcene, M Tanno, DA Gorog, R Bassi, MS Marber

EUROPEAN HEART JOURNAL   24   666 - 666   2003.8

Inhibition of p38 mitogen-activated protein kinase fails to attenuate contractile dysfunction in a mouse model of low-flow ischaemia

DA Gorog, M Tanno, R Bassi, AMN Kabir, MS Marber

EUROPEAN HEART JOURNAL   24   717 - 717   2003.8

Varying susceptibility to myocardial infarction among C57BL/6 of different genetic background

DA Gorog, M Tanno, AMN Kabir, GS Kanaganayagam, SG Fisher, R Bassi, MS Marber

EUROPEAN HEART JOURNAL   24   175 - 175   2003.8

Diverse mechanisms of myocardial p38 mitogen-activated protein kinase activation - Evidence for MKK-independent activation by a TAB1-associated mechanism contributing to injury during myocardial ischemia

M Tanno, R Bassi, DA Gorog, AT Saurin, J Jiang, RJ Heads, JL Martin, RJ Davis, RA Flavell, MS Marber

CIRCULATION RESEARCH   93 ( 3 )   254 - 261   2003.8

Varying susceptibility to myocardial infarction among C57BL/6 mice of different genetic background

DA Gorog, M Tanno, AMN Kabir, GS Kanaganayagam, R Bassi, SG Fisher, MS Marber

JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY   35 ( 6 )   705 - 708   2003.6

Interruption of signal transduction between G protein and PKC-epsilon underlies the impaired myocardial response to ischemic preconditioning in postinfarct remodeled hearts

T Miki, T Miura, M Tanno, J Sakamoto, A Kuno, S Genda, T Matsumoto, Y Ichikawa, K Shimamoto

MOLECULAR AND CELLULAR BIOCHEMISTRY   247 ( 1-2 )   185 - 193   2003.5

Diverse mechanisms are responsible for myocardial p38-MAPK activation in response to ischemia and tumour necrosis factor

M Tanno, R Bassi, A Saurin, M Marber

HEART   89   A14 - A14   2003.5

Infarct size limitation by nicorandil: Roles of mitochondrial K-ATP channels, sarcolemmal K-ATP channels, and protein kinase C

A Tsuchida, T Miura, M Tanno, J Sakamoto, T Miki, A Kuno, T Matsumoto, Y Ohnuma, Y Ichikawa, K Shimamoto

JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY   40 ( 8 )   1523 - 1530   2002.10

The role of mitochondrial KATP-channels in preconditioning in the Langendorff-perfused mouse heart - trigger or mediator?

AMN Kabir, M Tanno, DA Gorog, MJ Shattock, MS Marber

CLINICAL AND EXPERIMENTAL PHARMACOLOGY AND PHYSIOLOGY   29 ( 8 )   A87 - A88   2002.8

Opening of mitochondrial K-ATP channel occurs downstream of PKC-epsilon activation in the mechanism of preconditioning

Y Ohnuma, T Miura, T Miki, M Tanno, A Kuno, A Tsuchida, K Shimamoto

AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY   283 ( 1 )   H440 - H447   2002.7

Roles of microtubules and actin filaments in the mechanism of ischemic preconditioning

T Miura, T Miki, Y Ohnuma, M Tanno, K Shimamoto

CIRCULATION   104 ( 17 )   60 - 60   2001.10

Blockade of gap junction communication during the early period of ischemia protects cardiomyocytes from infarction

M Tanno, A Tsuchida, Y Nishino, T Matsumoto, S Genda, J Sakamoto, T Miura

CIRCULATION   104 ( 17 )   43 - 43   2001.10

Opening of the mitochondrial K-ATP channel is downstream of protein kinase C-epsilon activation in the cardioprotective mechanism of ischemic preconditioning

Y Ohnuma, T Miki, M Tanno, S Genda, A Kuno, T Miura

CIRCULATION   104 ( 17 )   16 - 16   2001.10

Failure of adenosine receptors to activate PKC-epsilon is responsible for loss of cardioprotection of preconditioning in the myocardium undergoing post-infarct remodeling

T Miki, T Miura, A Tsuchida, J Sakamoto, M Tanno, A Kuno, Y Nishino, K Shimamoto

CIRCULATION   104 ( 17 )   209 - 209   2001.10

Opening of the mitochondrial KATP channel occurs downstream of protein kinase C in the cardioprotective mechanism of ischaemic preconditioning

T Miki, T Miura, Y Ohnuma, M Tanno, A Kuno, T Matsumoto, K Shimamoto

EUROPEAN HEART JOURNAL   22   669 - 669   2001.9

Contribution of both the sarcolemmal K-ATP and mitochondrial K-ATP channels to infarct size limitation by K-ATP channel openers: differences from preconditioning in the role of sarcolemmal K-ATP channels

M Tanno, T Miura, A Tsuchida, T Miki, Y Nishino, Y Ohnuma, K Shimamoto

NAUNYN-SCHMIEDEBERGS ARCHIVES OF PHARMACOLOGY   364 ( 3 )   226 - 232   2001.9

Critical timing of mitochondrial K(ATP) channel opening for enhancement of myocardial tolerance against infarction

A Tsuchida, T Miura, T Miki, A Kuno, M Tanno, Y Nozawa, S Genda, T Matsumoto, K Shimamoto

BASIC RESEARCH IN CARDIOLOGY   96 ( 5 )   446 - 453   2001.9

Infarct size limitation by bradykinin receptor activation is mediated by the mitochondrial but not by the sarcolemmal KATP channel

H Kita, T Miura, T Miki, S Genda, M Tanno, T Fukuma, K Shimamoto

CARDIOVASCULAR DRUGS AND THERAPY   14 ( 5 )   497 - 502   2000.9

Subtypes of ATP-sensitive potassium channels (KATP) affording anti-infarct tolerance in the heart: mitochondrial KATP versus sarcolemmal KATP

M Tanno, T Miura, A Kuno, T Miki, A Tsuchida, K Shimamoto

EUROPEAN HEART JOURNAL   21   669 - 669   2000.8

コロキウムVII-1 Preconditioning効果 : 基礎の立場から

三浦 哲嗣, 土田 哲人, 三木 隆幸, 丹野 雅也, 野沢 幸永, 現田 聡, 島本 和明

Japanese circulation journal   64   94 - 94   2000.3

P268 Bradykinin受容体を介したpreconditioning機構にはmitochondrial K^<ATP> channelsが寄与する

北 宏之, 三浦 哲嗣, 土田 哲人, 三木 隆幸, 福真 隆行, 丹野 雅也, 野沢 幸永, 松本 倫明, 島本 和明

Japanese circulation journal   64   526 - 526   2000.3

Roles of tyrosine kinase and protein kinase C in infarct size limitation by repetitive ischemic preconditioning in the rat

M Tanno, A Tsuchida, Y Nozawa, T Matsumoto, T Hasegawa, T Miura, K Shimamoto

JOURNAL OF CARDIOVASCULAR PHARMACOLOGY   35 ( 3 )   345 - 352   2000.3

Critical timing of mitochondrial K-ATP channel opening for enhancement of myocardial tolerance against infarction

A Tsuchida, A Kuno, M Tanno, Y Nozawa, T Miura

CIRCULATION   100 ( 18 )   631 - 631   1999.11

0389 プレコンディショニングの反復による梗塞抑制効果の増強におけるtyrosine kinaseとprotein kinase Cの関与

丹野 雅也, 土田 哲人, 三浦 哲嗣, 野沢 幸永, 長谷川 徹, 島本 和明

Japanese circulation journal   63 ( 1 )   245 - 245   1999.3

Both tyrosine kinase and protein kinase C (PKC) are involved in infarct size limitation by repetitive preconditioning (PC) in the rat

M Tanno, A Tsuchida, T Miura, T Hasegawa, K Shimamota

CIRCULATION   98 ( 17 )   71 - 71   1998.10

0164 Ischemic preconditioning(PC)におけるATP-sensitive potasium channel(K_<ATP>)の寄与は虚血障害の持続時間に依存する

丹野 雅也, 土田 哲人, 野沢 幸永, 中野 淳, 三浦 哲嗣, 島本 和明

Japanese circulation journal   61   152 - 152   1997.3

Cross-talk of cardiomyocyte necroptosis and autophagy in heart failure

Grant number：18K08079  2018.4 - 2021.3

Japan Society for the Promotion of Science  Grants-in-Aid for Scientific Research  Grant-in-Aid for Scientific Research (C)

Tetsuji Miura

Development of novel therapeutic approach for diabetic cardiomyopathy by modification of AMP deaminase activity.

Grant number：17K09584  2017.4 - 2020.3

Japan Society for the Promotion of Science  Grants-in-Aid for Scientific Research  Grant-in-Aid for Scientific Research (C)

Tanno Masaya

The role of aberrant mTOR activation in heart failure

Grant number：16K09505  2016.4 - 2019.3

Japan Society for the Promotion of Science  Grants-in-Aid for Scientific Research  Grant-in-Aid for Scientific Research (C)

Yano Toshiyuki

Novel therapeutic approach for heart failure by suppression of mitochondrial translocation of GSK-3beta

Grant number：26461132  2014.4 - 2017.3

Japan Society for the Promotion of Science  Grants-in-Aid for Scientific Research  Grant-in-Aid for Scientific Research (C)

Tanno Masaya

Role of mitochondrial permeability transition in necroptosis of the cardiomyocyte

Grant number：26461133  2014.4 - 2017.3

Japan Society for the Promotion of Science  Grants-in-Aid for Scientific Research  Grant-in-Aid for Scientific Research (C)

Miura Tetsuji

Protein kinases regulating the mitochondrial permeability transition pore

Grant number：23591086  2011 - 2013

Japan Society for the Promotion of Science  Grants-in-Aid for Scientific Research  Grant-in-Aid for Scientific Research (C)

TETSUJI Miura, MIKI Takayuki, TANNO Masaya

Novel therapeutic approach for heart failure by promoting nuclear translocation of SIRT1, a protein deacetylase

Grant number：23591085  2011 - 2013

Japan Society for the Promotion of Science  Grants-in-Aid for Scientific Research  Grant-in-Aid for Scientific Research (C)

TANNO Masaya, MIURA Tetsuji, HORIO Yoshiyuki

Role of connexin-43 in protective signaling incardiomyocyte

Grant number：20590870  2008 - 2010

Japan Society for the Promotion of Science  Grants-in-Aid for Scientific Research  Grant-in-Aid for Scientific Research (C)

MIURA Tetsuji, MIKI Takayuki, TANNO Masaya

Clarification of mechanisms to regulate the activity of protein deacetylase SIRT1 and its therapeutic application in heart failure

Grant number：20590869  2008 - 2010

Japan Society for the Promotion of Science  Grants-in-Aid for Scientific Research  Grant-in-Aid for Scientific Research (C)

TANNO Masaya, MIURA Tetsuji, HORIO Yoshiyuki

ヒストン脱アセチル化酵素SIRT1の細胞内局在の調節と心不全治療への応用

Grant number：18790505  2006 - 2007

日本学術振興会  科学研究費助成事業  若手研究(B)

丹野 雅也