論文 - 丹野　雅也

糖尿病腎の心腎症候群type 1への感受性増加におけるTLRs/NOXsシグナル伝達とオートファジー障害の影響(Detrimental Roles of TLRs/NOXs Signaling and Impaired Autophagy in Increased Susceptibility of the Diabetic Kidney to Type 1 Cardiorenal Syndrome)

Kuno Atsushi, Sato Tatsuya, Kouzu Hidemichi, Yano Toshiyuki, Tanno Masaya, Miura Tetsuji

日本循環器学会学術集会抄録集 ( (一社)日本循環器学会 )  85回   PL09 - 1  2021年03月

ミトコンドリア関連ER膜および細胞質におけるAMPデアミナーゼの上昇は糖尿病心の圧負荷による心機能障害に大きく寄与する(Upregulated AMP Deaminase in Mitochondria-associated ER Membranes and Cytosol Distinctively Contributes to Pressure Overload-induced Cardiac Dysfunction in Diabetic Hearts)

Tanno Masaya, Osanami Arata, Kouzu Hidemichi, Ogawa Toshifumi, Kuno Atsushi, Miura Tetsuji

日本循環器学会学術集会抄録集 ( (一社)日本循環器学会 )  85回   SS14 - 4  2021年03月

院外心停止蘇生後患者における血液凝固/線溶異常の予後的意義(Prognostic Value of Abnormalities in the Coagulation/Fibrinolysis Status in Patients after Resuscitation from Out-of-Hospital Cardiac Arrest)

中田 潤, 國分 宣明, 永野 伸卓, 西川 諒, 高橋 遼, 岸上 直広, 大友 俊作, 小山 雅之, 丹野 雅也, 三浦 哲嗣

日本循環器学会学術集会抄録集 ( (一社)日本循環器学会 )  85回   OJ26 - 6  2021年03月

Mitochondrial associated ER membraneにおけるAMPD3の役割とミトコンドリア膜透過性遷移の閾値制御(Role of AMPD3 in Mitochondria-associated ER Membranes in Regulation of Threshold for Mitochondrial Permeability Transition)

Osanami Arata, Tanno Masaya, Kuno Atsushi, Kouzu Hidemichi, Yano Toshiyuki, Ogawa Toshifumi, Sato Tatsuya, Miura Tetsuji

日本循環器学会学術集会抄録集 ( (一社)日本循環器学会 )  85回   OE080 - 6  2021年03月

AMPデアミナーゼの細胞内局在化とXORによるROS生成におけるCytosolic AMPDの役割(Intracellular Localization of AMP Deaminase and a Role of Cytosolic AMPD in XOR-mediated ROS Production)

Osanami Arata, Tanno Masaya, Kuno Atsushi, Kouzu Hidemichi, Yano Toshiyuki, Ogawa Toshifumi, Sato Tatsuya, Miura Tetsuji

日本循環器学会学術集会抄録集 ( (一社)日本循環器学会 )  85回   OE081 - 6  2021年03月

Prognostic Value of Abnormalities in the Coagulation/Fibrinolysis Status in Patients after Resuscitation from Out-of-Hospital Cardiac Arrest(和訳中)

中田 潤, 國分 宣明, 永野 伸卓, 西川 諒, 高橋 遼, 岸上 直広, 大友 俊作, 小山 雅之, 丹野 雅也, 三浦 哲嗣

日本循環器学会学術集会抄録集 ( (一社)日本循環器学会 )  85回   OJ26 - 6  2021年03月

Xanthine oxidoreductase-mediated injury is amplified by upregulated AMP deaminase in type 2 diabetic rat hearts under the condition of pressure overload.

Yusuke Igaki, Masaya Tanno, Tatsuya Sato, Hidemichi Kouzu, Toshifumi Ogawa, Arata Osanami, Toshiyuki Yano, Atsushi Kuno, Takayuki Miki, Takashi Nakamura, Tetsuji Miura

Journal of molecular and cellular cardiology   154   21 - 31  2021年02月  [査読有り]  [国際誌]

　概要を見る

BACKGROUND: We previously reported that upregulated AMP deaminase (AMPD) contributes to diastolic ventricular dysfunction via depletion of the adenine nucleotide pool in a rat model of type 2 diabetes (T2DM), Otsuka Long-Evans-Tokushima Fatty rats (OLETF). Meanwhile, AMPD promotes the formation of substrates of xanthine oxidoreductase (XOR), which produces ROS as a byproduct. Here, we tested the hypothesis that a functional link between upregulated AMPD and XOR is involved in ventricular dysfunction in T2DM rats. METHODS AND RESULTS: Pressure-volume loop analysis revealed that pressure overloading by phenylephrine infusion induced severer left ventricular diastolic dysfunction (tau: 14.7 ± 0.8 vs 12.5 ± 0.7 msec, left ventricular end-diastolic pressure: 18.3 ± 1.5 vs 12.2 ± 1.3 mmHg, p < 0.05) and ventricular-arterial uncoupling in OLETF than in LETO, non-diabetic rats, though the baseline parameters were comparable in the two groups. While the pressure overload did not affect AMPD activity, it increased XOR activity both in OLETF and LETO, with OLETF showing significantly higher XOR activity than that in LETO (347.2 ± 17.9 vs 243.2 ± 6.1 μg/min/mg). Under the condition of pressure overload, myocardial ATP level was lower, and levels of xanthine and uric acid were higher in OLETF than in LETO. Addition of exogenous inosine, a product of AMP deamination, to the heart homogenates augmented XOR activity. OLETF showed 68% higher tissue ROS levels and 47% reduction in mitochondrial state 3 respiration compared with those in LETO. Overexpression of AMPD3 in H9c2 cells elevated levels of hypoxanthine and ROS and reduced the level of ATP. Inhibition of XOR suppressed the production of tissue ROS and mitochondrial dysfunction and improved ventricular function under the condition of pressure overload in OLETF. CONCLUSIONS: The results suggest that increases in the activity of XOR and the formation of XOR substrates by upregulated AMPD contribute to ROS-mediated diastolic ventricular dysfunction at the time of increased cardiac workload in diabetic hearts.

DOI PubMed

Activation of the angiotensin II receptor promotes autophagy in renal proximal tubular cells and affords protection from ischemia/reperfusion injury

Hirohito Sugawara, Norihito Moniwa, Atsushi Kuno, Wataru Ohwada, Arata Osanami, Satoru Shibata, Yukishige Kimura, Koki Abe, Yufu Gocho, Masaya Tanno, Tetsuji Miura

Journal of Pharmacological Sciences ( Elsevier BV )  145 ( 2 ) 187 - 197  2021年02月  [査読有り]

DOI

経口ブドウ糖負荷試験で診断し得た機能性低血糖症の1例

寺沢 誠, 長南 新太, 佐藤 達也, 原田 なお, 川原田 航, 箱崎 頌平, 後町 結, 茂庭 仁人, 矢野 俊之, 古橋 眞人, 丹野 雅也, 三浦 哲嗣

日本内分泌学会雑誌 ( (一社)日本内分泌学会 )  96 ( 3 ) 596 - 596  2021年01月

Distinct intra-mitochondrial localizations of pro-survival kinases and regulation of their functions by DUSP5 and PHLPP-1

Wataru Ohwada, Masaya Tanno, Toshiyuki Yano, Sang-Bing Ong, Koki Abe, Tatsuya Sato, Atsushi Kuno, Takayuki Miki, Hirohito Sugawara, Yusuke Igaki, Tetsuji Miura

Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease ( Elsevier BV )  1866 ( 10 ) 165851 - 165851  2020年10月  [査読有り]

DOI

非専門医の外来診療における慢性合併症評価率の年次変化

小川 俊史, 佐藤 達也, 三木 隆幸, 東浦 幸村, 伊野 祥哉, 矢野 俊之, 古橋 眞人, 神津 英至, 丹野 雅也, 斎藤 重幸, 三浦 哲嗣

糖尿病 ( (一社)日本糖尿病学会 )  63 ( Suppl.1 ) S - 204  2020年08月

非虚血性拡張型心筋症において核内および介在板に局在するnecroptosisの実行因子リン酸化MLKLは各々独立して働いている(Phosphorylated MLKL, an Executor of Necroptosis, Localized in the Nucleus and Intercalated Disc Plays Distinct Roles in Nonischemic Dilated Cardiomyopathy)

Fujita Yugo, Yano Toshiyuki, Nagano Nobutaka, Nishikawa Ryo, Kamiyama Naoyuki, Fujito Takefumi, Mochizuki Atsushi, Koyama Masayuki, Kouzu Hidemichi, Muranaka Atsuko, Nagahara Daigo, Tanno Masaya, Miki Takayuki, Miura Tetsuji

日本循環器学会学術集会抄録集 ( (一社)日本循環器学会 )  84回   OE61 - 5  2020年07月

ドキソルビシン誘発性心筋症の発症には鉄結合タンパク質ではなく遊離鉄のミトコンドリアへの蓄積が関与している可能性がある(Accumulation of Free Iron, but not Protein-bound Iron, in Mitochondria may Contribute to Development of Doxorubicin-induced Cardiomyopathy)

Sato Tatsuya, Kikuchi Tatsuya, Yano Toshiyuki, Miki Takayuki, Tanno Masaya, Kuno Atsushi, Kouzu Hidemichi, Miura Tetsuji

日本循環器学会学術集会抄録集 ( (一社)日本循環器学会 )  84回   PE48 - 7  2020年07月

糖尿病外来診療における慢性合併症評価の実態調査

小川 俊史, 佐藤 達也, 東浦 幸村, 伊野 祥哉, 矢野 俊之, 古橋 眞人, 丹野 雅也, 三木 隆幸, 斎藤 重幸, 三浦 哲嗣

糖尿病 ( (一社)日本糖尿病学会 )  63 ( 5 ) 356 - 356  2020年05月

mTORC1 inhibition attenuates necroptosis through RIP1 inhibition-mediated TFEB activation

Abe K, Yano T, Tanno M, Miki T, Kuno A, Sato T, Kouzu H, Nakata K, Ohwada W, Kimura Y, Sugawara H, Shibat S, Igaki Y, Ino S, Miura T

BBA Molecular Basis of Disease   1865 ( 12 ) 165552  2019年12月  [査読有り]

DOI PubMed

心不全と心腎連関における髄質集合管バソプレシンV2受容体の役割 BOREAS-ADHFレジストリ解析結果より

丹野 雅也, 永野 伸卓, 能登 貴弘, 長南 新太, 神津 英至, 三浦 哲嗣

日本心臓病学会学術集会抄録 ( (一社)日本心臓病学会 )  67回   SS - 3  2019年09月

Canagliflozin, an SGLT2 inhibitor, normalizes renal susceptibility to type 1 cardiorenal syndrome through reduction of renal oxidative stress in diabetic rats.

Kimura Y, Kuno A, Tanno M, Sato T, Ohno K, Shibata S, Nakata K, Sugawara H, Abe K, Igaki Y, Yano T, Miki T, Miura T

Journal of Diabetes Investigation   10 ( 4 ) 933 - 946  2019年07月  [査読有り]

DOI PubMed

mTORC1活性阻害はRIP1の抑制的リン酸化により心筋細胞のネクロプトーシスを抑制する

矢野 俊之, 安倍 功記, 佐藤 達也, 神津 英至, 久野 篤史, 丹野 雅也, 三木 隆幸, 三浦 哲嗣

日本循環制御医学会総会プログラム・抄録集 ( 日本循環制御医学会 )  40回   63 - 63  2019年06月

Accuracy of flash glucose monitoring in insulin-treated patients with type 2 diabetes.

Tatsuya Sato, Hiroto Oshima, Kei Nakata, Yukishige Kimura, Toshiyuki Yano, Masato Furuhashi, Masaya Tanno, Takayuki Miki, Tetsuji Miura

Journal of diabetes investigation   10 ( 3 ) 846 - 850  2019年05月  [査読有り]  [国内誌]

　概要を見る

The present study evaluated the accuracy of interstitial glucose measurements by flash glucose monitoring (FGM) and continuous glucose monitoring (CGM). Five diabetes patients simultaneously underwent FGM (FreeStyle Libre Pro) and CGM (iPro™2), and their glucose levels were compared with venous blood and capillary blood glucose levels. The range of daily venous blood glucose levels (30 measurements) was 70-245 mg/dL, with a median of 138 mg/dL. There were good correlations of glucose levels measured by FGM (r2  = 0.90, mean absolute relative difference 8.2 ± 5.6%), CGM (r2  = 0.86, mean absolute relative difference 9.2 ± 9.1%) and capillary blood (r2  = 0.87, mean absolute relative difference 7.2 ± 7.2%) with venous blood glucose levels. The accuracy of FGM measurements was also shown against CGM, with 99.9% of the FGM values (1,279 measurements) being within the Parkes error grid zones A and B. The results suggest that the accuracy of FGM is similar to that of CGM, and that FGM is a useful tool for determining daily glucose profile.

DOI PubMed

AKIに対するアンジオテンシンII前投与による腎保護効果はAT1およびMas受容体減少の軽減とautophagy活性化を伴う

菅原 浩仁, 茂庭 仁人, 柴田 智, 矢野 俊之, 久野 篤史, 丹野 雅也, 三木 隆幸, 三浦 哲嗣

日本腎臓学会誌 ( (一社)日本腎臓学会 )  61 ( 3 ) 285 - 285  2019年05月