論文 - 丹野　雅也

Type 2 diabetes induces subendocardium-predominant reduction in transient outward K+ current with downregulation of Kv4.2 and KChIP2.

Sato T, Kobayashi T, Kuno A, Miki T, Tanno M, Kouzu H, Itoh T, Ishikawa S, Kojima T, Miura T, Tohse N

American journal of physiology. Heart and circulatory physiology   306 ( 7 ) H1054 - 65  2014年04月  [査読有り]

DOI PubMed

ミトコンドリアKATPチャンネル活性化による酸化ストレス後のmPTP再閉鎖促進は残存ROS産生の抑制により達成される(Acceleration of mPTP Re-closure after Oxidant Stress by Mitochondrial KATP Channel Activation is Achieved by Suppression of Residual ROS Production)

Ogasawara Makoto, Tanno Masaya, Kuno Atsushi, Ishikawa Satoko, Murase Hiromichi, Tobisawa Toshiyuki, Kouzu Hidemichi, Yano Toshiyuki, Miki Takayuki, Miura Tetsuji

Circulation Journal ( (一社)日本循環器学会 )  78 ( Suppl.I ) 323 - 324  2014年03月

慢性腎不全は虚血/再灌流傷害に対する心筋感受性を高める(Chronic Renal Failure Enhances Myocardial Susceptibility to Ischemia/Reperfusion Injury)

Tobisawa Toshiyuki, Yano Toshiyuki, Miki Takayuki, Tanno Masaya, Kuno Atsushi, Kouzu Hidemichi, Murase Hiromichi, Ogasawara Makoto, Ishikawa Satoko, Yoshida Hideaki, Miura Tetsuji

Circulation Journal ( (一社)日本循環器学会 )  78 ( Suppl.I ) 269 - 269  2014年03月

糖尿病ラットにおいてIncretinを中心とする治療により心筋オートファジーフラックスが回復し、心筋梗塞後の死亡率が減少する(Incretin-based Therapy Restores Myocardial Autophagic Flux and Reduces Mortality after Myocardial Infarction in Diabetic Rats)

Murase Hiromichi, Kuno Atsushi, Miki Takayuki, Tanno Masaya, Yano Toshiyuki, Kouzu Hidemichi, Tobisawa Toshiyuki, Ogasawara Makoto, Ishikawa Satoko, Miura Tetsuji

Circulation Journal ( (一社)日本循環器学会 )  78 ( Suppl.I ) 401 - 402  2014年03月

心保護シグナル伝達におけるmTORC2およびリボソーム蛋白質S6の中心的役割(The Pivotal Role of mTORC2 and Ribosomal Protein S6 in Cardioprotective Signaling)

Yano Toshiyuki, Miki Takayuki, Tanno Masaya, Kuno Atsushi, Kouzu Hidemichi, Murase Hiromichi, Ogasawara Makoto, Tobisawa Toshiyuki, Ishikawa Satoko, Miura Tetsuji

Circulation Journal ( (一社)日本循環器学会 )  78 ( Suppl.I ) 470 - 470  2014年03月

Accelerated recovery of mitochondrial membrane potential by GSK-3β inactivation affords cardiomyocytes protection from oxidant-induced necrosis.

Sunaga D, Tanno M, Kuno A, Ishikawa S, Ogasawara M, Yano T, Miki T, Miura T

PloS one   9 ( 11 ) e112529  2014年  [査読有り]

DOI PubMed

VDAC2との相互作用はGSK3Bのミトコンドリア移行をキナーゼ活性依存性に促進し、細胞死を誘発する(Interaction with VDAC2 Promotes Mitochondrial Translocation of GSK3β in a Kinase Activity-Dependent Manner and Induces Cell Death)

Tanno Masaya, Sunaga Daisuke, Ishikawa Satoko, Itoh Takahito, Kouzu Hidemichi, Sato Tatsuya, Kuno Atsushi, Murase Hiromichi, Miki Takayuki, Miura Tetsuji

Circulation Journal ( (一社)日本循環器学会 )  77 ( Suppl.I ) 55 - 56  2013年03月

Titinによる心室スティフネスの変化は、2型糖尿病心臓における急性収縮期圧負荷により示された拡張機能障害を生じる可能性がある(Changes in Titin-based Ventricular Stiffness May Underlie Diastolic Dysfunction Unmasked by Acute Systolic Pressure Overloading in Type 2 Diabetic Hearts)

Kouzu Hidemichi, Kuno Atsushi, Miki Takayuki, Tanno Masaya, Itoh Takahito, Sato Tatsuya, Sunaga Daisuke, Murase Hiromichi, Miura Tetsuji

Circulation Journal ( (一社)日本循環器学会 )  77 ( Suppl.I ) 64 - 64  2013年03月

虚血中のcyclophilin Dと無機リン酸担体の相互作用はmPTP開口の閾値と再灌流誘発性細胞壊死を決定する(Interaction of Cyclophilin D with Inorganic Phosphate Carrier during Ischemia Determines Threshold for mPTP Opening and Reperfusion-induced Cell Necrosis)

Itoh Takahito, Miki Takayuki, Tanno Masaya, Kuno Atsushi, Kouzu Hidemichi, Sato Tatsuya, Sunaga Daisuke, Murase Hiromichi, Ishikawa Satoko, Miura Tetsuji

Circulation Journal ( (一社)日本循環器学会 )  77 ( Suppl.I ) 45 - 45  2013年03月

mPTP再閉鎖の促進はROS誘発性壊死を防ぐミトコンドリアKATPチャネルの活性化によって心筋細胞を防御する(Promotion of Re-closure of the mPTP Underlies Cardiomyocyte Protection by Activation of the Mitochondrial KATP Channel against ROS-induced Necrosis)

Sunaga Daisuke, Kuno Atsushi, Ishikawa Satoko, Miki Takayuki, Tanno Masaya, Kouzu Hidemichi, Itoh Takahito, Sato Tatsuya, Murase Hiromichi, Miura Tetsuji

Circulation Journal ( (一社)日本循環器学会 )  77 ( Suppl.I ) 245 - 245  2013年03月

2型糖尿病の心筋におけるミトコンドリア蛋白脱アセチル化酵素SIRT3の役割(Role of SIRT3, a Mitochondrial Protein Deacetylase, in Type 2 Diabetic Myocardium)

Kuno Atsushi, Itoh Takahito, Sato Tatsuya, Kouzu Hidemichi, Tanno Masaya, Miki Takayuki, Horio Yoshiyuki, Miura Tetsuji

Circulation Journal ( (一社)日本循環器学会 )  77 ( Suppl.I ) 168 - 168  2013年03月

Resveratrol improves cardiomyopathy in dystrophin-deficient mice through SIRT1 protein-mediated modulation of p300 protein.

Kuno A, Hori YS, Hosoda R, Tanno M, Miura T, Shimamoto K, Horio Y

The Journal of biological chemistry   288 ( 8 ) 5963 - 5972  2013年02月  [査読有り]

DOI PubMed

特発性右房拡張症の1例

菅原 浩仁, 小笠原 惇, 村中 敦子, 川向 美奈, 望月 敦史, 伊藤 孝仁, 丹野 雅也, 下重 晋也, 湯田 聡, 橋本 暁佳, 土橋 和文, 三浦 哲嗣

超音波医学 ( (公社)日本超音波医学会 )  40 ( 1 ) 33 - 33  2013年01月

Histopathology of the pancreas in fulminant type 1 diabetes after 23-year follow-up: a case report

Tatsuya Sato, Takayuki Miki, Naoto Murakami, Yoshihiko Hirohashi, Hidemichi Kouzu, Masato Furuhashi, Masaya Tanno, Satoshi Yuda, Shigeyuki Saitoh, Tadashi Hasegawa, Tetsuji Miura

PATHOLOGY INTERNATIONAL ( WILEY-BLACKWELL )  62 ( 12 ) 827 - 829  2012年12月  [査読有り]

DOI PubMed

Cytoprotective regulation of the mitochondrial permeability transition pore is impaired in type 2 diabetic Goto-Kakizaki rat hearts.

Itoh T, Kouzu H, Miki T, Tanno M, Kuno A, Sato T, Sunaga D, Murase H, Miura T

Journal of molecular and cellular cardiology   53 ( 6 ) 870 - 879  2012年12月  [査読有り]

DOI PubMed

軽度血圧上昇を伴う肥満2型糖尿病が左室・動脈カップリングに及ぼす影響

神津 英至, 須永 大介, 高田 明典, 久野 篤史, 丹野 雅也, 三木 隆幸, 三浦 哲嗣

日本高血圧学会総会プログラム・抄録集 ( (NPO)日本高血圧学会 )  35回   475 - 475  2012年09月

Emerging beneficial roles of sirtuins in heart failure.

Tanno M, Kuno A, Horio Y, Miura T

Basic research in cardiology   107 ( 4 ) 273  2012年07月  [査読有り]

DOI PubMed

Role of connexin-43 in protective PI3K-Akt-GSK-3β signaling in cardiomyocytes.

Ishikawa S, Kuno A, Tanno M, Miki T, Kouzu H, Itoh T, Sato T, Sunaga D, Murase H, Miura T

American journal of physiology. Heart and circulatory physiology   302 ( 12 ) H2536 - 44  2012年06月  [査読有り]

DOI PubMed

The mPTP and its regulatory proteins: final common targets of signalling pathways for protection against necrosis

Tetsuji Miura, Masaya Tanno

CARDIOVASCULAR RESEARCH ( OXFORD UNIV PRESS )  94 ( 2 ) 181 - 189  2012年05月  [査読有り]

　概要を見る

The mitochondrial permeability transition pore (mPTP) is a non-selective, large-conductance channel that is closed under physiological conditions. Opening of the mPTP, leading to abolition of mitochondrial functions, is a major mechanism of myocyte necrosis by ischaemia/reperfusion, and direct inhibition of mPTP opening by use of pharmacological or genetic manipulations limits infarct size in vivo. Multiple pro-survival signal pathways commonly target the mPTP and inhibit its opening. Although the molecular structure of the mPTP has not been established, recent studies have characterized roles of each mPTP subunit and functions of several proteins directly interacting with the mPTP. This article briefly describes the understanding of mPTP regulation and interaction of the mPTP with four proteins (hexokinase II, glycogen synthase kinase-3, signal transducer and activator of transcription 3, and sirtuin 3) that are downstream of signal pathways relevant to protection from ischaemia/reperfusion injury.

DOI PubMed

糖尿病の心臓において、無機リン酸輸送体のANTおよびシクロフィリンDとの相互作用増大がmPTP調節異常の根底にある(Increased Interaction of Inorganic Phosphate Carrier with ANT and Cyclophilin D Underlies Dysregulation of the mPTP in Diabetetic Hearts)

Itoh Takahito, Kouzu Hidemichi, Miki Takayuki, Tanno Masaya, Kuno Atsushi, Satoh Tatsuya, Sunaga Daisuke, Murase Hiromichi, Ishikawa Satoko, Miura Tetsuji

Circulation Journal ( (一社)日本循環器学会 )  76 ( Suppl.I ) 2171 - 2171  2012年03月