BABA Tsuyoshi

写真a

Affiliation

School of Medicine, Department of Obstetrics and Gynecology

Job title

Associate Professor
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Degree 【 display / non-display 】

  • 2001.03   Ph.D

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Professional Memberships 【 display / non-display 】

  • 2005.04
    -
    Now

    Japan Society for Reproductive Medicine

  • 1996.04
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    Now

    日本産科婦人科学会

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    Now

    日本人類遺伝学会

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    Now

    European Society of Human Reproduction and Embryology

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    Now

    日本不育症学会

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Research Areas 【 display / non-display 】

  • Life sciences   Obstetrics and gynecology  

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Affiliation 【 display / non-display 】

  • Sapporo Medical University   School of Medicine, Dept.of Obstetrics and Gynecology   Associate Professor  

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Papers 【 display / non-display 】

  • Pregnancy-specific beta-1-glycoprotein 6 is a potential novel diagnostic biomarker of placenta accreta spectrum.

    Hazuki Kashiwagi, Tasuku Mariya, Mina Umemoto, Shiori Ogawa, Yoshihiko Hirohashi, Yuya Fujibe, Terufumi Kubo, Masayuki Someya, Tsuyoshi Baba, Shinichi Ishioka, Toshihiko Torigoe, Tsuyoshi Saito

    Medical molecular morphology    2023.10  [Domestic journal]

    　View Summary

    Early diagnosis is essential for the safer perinatal management of placenta accreta spectrum (PAS). We used transcriptome analysis to investigate diagnostic maternal serum biomarkers and the mechanisms of PAS development. We analyzed eight formalin-fixed paraffin-embedded placental specimens from two placenta increta and three placenta percreta cases who underwent cesarean hysterectomy at Sapporo Medical University Hospital between 2013 and 2019. Invaded placental regions were isolated from the uterine myometrium and RNA was extracted. The transcriptome difference between normal placenta and PAS was analyzed by microarray analysis. The PAS group showed markedly decreased expression of placenta-specific genes such as LGALS13 and the pregnancy-specific beta-1-glycoprotein (PSG) family. Term enrichment analysis revealed changes in genes related to cellular protein catabolic process, female pregnancy, autophagy, and metabolism of lipids. From the highly dysregulated genes in the PAS group, we investigated the expression of PSG family members, which are secreted into the intervillous space and can be detected in maternal serum from the early stage of pregnancy. The gene expression level of PSG6 in particular was progressively decreased from placenta increta to percreta. The PSG family, especially PSG6, is a potential biomarker for PAS diagnosis.

    DOI PubMed

  • Endocrinological and Metabolic Heterogeneity is low in Japanese Women with Polycystic Ovary Syndrome.

    Tsuyoshi Baba, Toshiaki Endo, Tasuku Mariya, Yoshika Kuno, Hiroyuki Honnma, Mika Kanaya, Tsuyoshi Saito

    Journal of obstetrics and gynaecology Canada : JOGC = Journal d'obstetrique et gynecologie du Canada : JOGC     102217 - 102217  2023.09  [International journal]

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    OBJECTIVE: This study aims to evaluate the endocrine differences among polycystic ovary syndrome (PCOS) phenotypes in Japanese women. METHODS: 118 Japanese women that we diagnosed with PCOS agreed to be included in the study. The study group was classified into the following four phenotypes: A) hyperandrogenism (HA); ovulatory disorder (OvD) and polycystic ovary morphology (PCOM); B) HA and OvD; C) HA and PCOM; and D) OvD and PCOM. We also recruited 66 healthy Japanese women to the study as control participants. Age, body mass index, androgens, luteinizing hormone, follicle-stimulating hormone, and insulin resistance index were evaluated and compared. RESULTS: The proportions of phenotypes A, B, C, and D were 57/120 (47.5%), 4/120 (3.3%), 13/120 (10.8%), and 46/120 (38.3%), respectively. The proportion of phenotype B was too small; therefore, phenotypes A and B were grouped as classical PCOS for intergroup comparisons. The luteinizing hormone/follicle-stimulating hormone ratio in the classical PCOS group was higher than that in the phenotype D group (P < 0.001). Androgen concentrations in the phenotype D group were significantly lower than those in the other groups (P < 0.01). Phenotype D was more common in lean women with PCOS. The surrogate marker of insulin resistance (homeostasis model assessment of insulin resistance (HOMA-IR)) was not different irrespective of PCOS and its phenotypes. CONCLUSION: Except for androgens, endocrine differences by PCOS phenotype are not evident, suggesting that diversity among patients with PCOS is relatively low in Japanese women.

    DOI PubMed

  • 不育症カップルがPGT-SR受検を決定する因子と意思決定支援に求められる遺伝カウンセリングのあり方についての検討

    久々宇 千恵, 石川 亜貴, 真里谷 奨, 馬場 剛, 遠藤 俊明, 櫻井 晃洋

    日本遺伝カウンセリング学会誌 ( (一社)日本遺伝カウンセリング学会 )  44 ( 2 ) 155 - 155  2023.06

  • 巨大腺筋症に対する開腹子宮頸管縫縮術を施行し,救命可能週数まで妊娠継続できた一絨毛膜二羊膜双胎の1例

    常松 梨紗, 石岡 伸一, 馬場 剛, 真里谷 奨, 染谷 真行, 新開 翔太, 齋藤 豪

    日本周産期・新生児医学会雑誌 ( (一社)日本周産期・新生児医学会 )  59 ( Suppl.1 ) P322 - P322  2023.06

  • Aggressive angiomyxoma(AAM)合併妊娠の一例

    古来 愛香, 石岡 伸一, 新開 翔太, 常松 梨紗, 真里谷 奨, 染谷 真行, 松浦 基樹, 馬場 剛, 齋藤 剛

    日本周産期・新生児医学会雑誌 ( (一社)日本周産期・新生児医学会 )  59 ( Suppl.1 ) P438 - P438  2023.06

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Misc 【 display / non-display 】

  • Editor’s Focus: Maternal Alcohol Use and Fetal Growth in Japan

    Kazutoshi Cho, Sumitaka Kobayashi, Atsuko Araki, Chihiro Miyashita, Sachiko Itoh, Yasuaki Saijo, Yoshiya Ito, Kazuo Sengoku, Tsuyoshi Baba, Hisanori Minakami, Yuichi Nakamura, Reiko Kishi, The Japan Environment and Children’s Study Group

    Pediatric Research ( Springer Science and Business Media LLC )  92 ( 1 ) 1 - 1  2022.07  [Invited]  [International journal]

    Article, review, commentary, editorial, etc. (scientific journal)  

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    掲載論文（責任著者）が、Pediatric Research volume 92 No. 1 July 2022のEditor’s Focusに選出され紹介された。掲載論文：Kazutoshi Cho, Sumitaka Kobayashi, et al. Prenatal alcohol exposure and adverse fetal growth restriction: findings from the Japan Environment and Children's Study. Pediatric Research. 2022; 92: 291-298. https://doi.org/10.1038/s41390-021-01595-3.

    DOI

  • 当院における思春期前症例の卵巣組織ガラス化保存と周術期の問題点について

    馬場 剛, 玉手 雅人, 春日 芙貴子, 長尾 沙智子, 藤部 佑哉, 木井 菜摘, 君塚 基修, 齋藤 豪

    日本がん・生殖医療学会誌 ( (一社)日本がん・生殖医療学会 )  5 ( 1 ) 139 - 139  2022.01

  • 妊娠に至ったGonadotropin resistant ovaryの1症例

    久野 芳佳, 馬場 剛, 春日 芙貴子, 古来 愛香, 玉手 雅人, 小川 万梨絵, 池田 桂子, 森下 美幸, 遠藤 俊明, 齋藤 豪

    日本生殖医学会雑誌 ( (一社)日本生殖医学会 )  66 ( 4 ) 403 - 403  2021.10

  • 当科における卵巣組織凍結の報告と北海道内の同技術の認識について

    古来 愛香, 玉手 雅人, 春日 芙貴子, 長尾 沙智子, 小川 万梨絵, 池田 桂子, 久野 芳佳, 森下 美幸, 馬場 剛, 齋藤 豪

    日本生殖医学会雑誌 ( (一社)日本生殖医学会 )  66 ( 4 ) 316 - 316  2021.10

  • 月経不順を契機に診断されたトルコ鞍黄色肉芽腫の1例

    小川 万梨絵, 馬場 剛, 春日 芙貴子, 古来 愛香, 玉手 雅人, 池田 桂子, 森下 美幸, 久野 芳佳, 遠藤 俊明, 齋藤 豪

    日本生殖医学会雑誌 ( (一社)日本生殖医学会 )  66 ( 4 ) 346 - 346  2021.10

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Research Projects 【 display / non-display 】

  • The role of genetic polymorphisms in polycystic ovary syndrome

    Grant-in-Aid for Young Scientists (B)

    Project Year :

    2008
    -
    2010
     

    BABA Tsuyoshi

    　View Summary

    We revealed that the SNPs IRS-1 Gly972Arg and RETN-420 C/G are predisposing factors in PCOS. PCOS patients who have RETN-420 homozygous variant genotype showed significantly higher BMI, higher fasting serum insulin levels, and lower serum adiponectin levels.

  • 多嚢胞性卵巣症候群におけるインスリン抵抗性

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