馬場　剛 (ババ　ツヨシ)

写真a

所属

医学部 産婦人科学講座産科周産期科学分野

職名

准教授
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  • 2001年03月   医学博士

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所属学協会 【 表示 ／ 非表示 】

  • 2005年04月
    -
    継続中

    日本生殖医学会

  • 1996年04月
    -
    継続中

    日本産科婦人科学会

  • 　
    -
    継続中

    日本人類遺伝学会

  • 　
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    継続中

    日本がん・生殖医療学会

  • 　
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    継続中

    日本内分泌学会

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研究分野 【 表示 ／ 非表示 】

  • ライフサイエンス   産婦人科学  

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researchmapの所属 【 表示 ／ 非表示 】

  • 札幌医科大学   医学部 医学科 産婦人科学講座 医学部医学科臨床医学部門講座産婦人科学講座   准教授  

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  • Japan Society of Obstetrics and Gynecology revised diagnostic criteria for polycystic ovary syndrome: JSOG2024 criteria.

    Hiroki Noguchi, Akira Iwase, Takeshi Iwasa, Haruhiko Kanasaki, Fuminori Kimura, Koji Kugu, Kazuki Saito, Tsuyoshi Baba, Tetsuaki Hara, Saki Minato, Rie Yanagihara, Toshiya Matsuzaki

    The journal of obstetrics and gynaecology research   51 ( 1 ) e16152  2025年01月  [国際誌]

    　概要を見る

    Japanese patients with polycystic ovary syndrome (PCOS) exhibit distinct body type characteristics, such that the rate of overweight/obese women is remarkably low. In addition, hyperandrogenism is relatively rare among Japanese PCOS patients. Therefore, these factors are considered in PCOS diagnostic criteria used in Japan. Diagnostic criteria for PCOS were recently revised by the Japan Society of Obstetrics and Gynecology based on a nationwide survey of PCOS and released on December 5, 2023 (JSOG2024). JSOG2024 criteria diagnosed PCOS according to the following three items: (1) irregular menstrual cycle/chronic anovulation, (2) polycystic ovarian morphology or elevated serum anti-Müllerian hormone (AMH) level, and (3) hyperandrogenism or high luteinizing hormone. The presence of all three items is required to diagnose PCOS, after excluding other diseases with symptoms similar to PCOS. We also established AMH cut-off values by age and a system for evaluating ovarian findings useful for both the JSOG2024 and Rotterdam criteria. We anticipate that the JSOG2024 criteria with cut-off values will enhance the treatment of Japanese patients with PCOS and those of other ethnicities with low obesity and hirsutism.

    DOI PubMed

  • Phenotypes and clinical laboratory data for polycystic ovary syndrome cases: A nationwide survey in Japan.

    Hiroki Noguchi, Takeshi Iwasa, Akira Iwase, Haruhiko Kanasaki, Fuminori Kimura, Koji Kugu, Kazuki Saito, Tsuyoshi Baba, Tetsuaki Hara, Toshiya Matsuzaki

    The journal of obstetrics and gynaecology research   50 ( 12 ) 2346 - 2356  2024年12月  [国際誌]

    　概要を見る

    AIM: Describe the current phenotypes and clinical laboratory data regarding polycystic ovary syndrome (PCOS) in Japan, taking into account ethnic differences and obesity status. METHODS: Data for 986 PCOS cases and 965 control cases were collected using a nationwide survey in Japan. Obese/overweight (body mass index [BMI] ≥25 kg/m2) and non-obese/overweight (BMI <25 kg/m2) cases were compared. RESULTS: Japanese PCOS cases predominantly involved non-obese/overweight patients, accounting for 75% of all cases. Among non-obese/overweight PCOS cases, the incidence of both amenorrhea and clinical/biochemical hyperandrogenism was significantly lower than in obese/overweight PCOS cases, whereas the rate of elevated serum luteinizing hormone (LH) level was significantly higher. Even though the incidence of hirsutism in Japan is only 13.5%, the detection rate for hyperandrogenism increased by as much as 30.4% when hirsutism was added to the Japan Society of Obstetrics and Gynecology (JSOG) criteria for the diagnosis of hyperandrogenism in addition to elevated serum total testosterone level. When evaluated based on timing of blood sampling, the LH level and LH/follicle-stimulating hormone ratio determined at the initial consultation involving a chief complaint of irregular menstrual cycle (after confirming the absence of follicles measuring ≥1 cm in diameter) were significantly higher than on days 2-3 or 4-6 of the menstrual cycle. CONCLUSIONS: Ethnic differences, including obesity status, affected the phenotype and clinical laboratory data of Japanese PCOS patients, such as the incidence rates of clinical/biochemical hyperandrogenism and the rate of elevated basal LH level. Adding hirsutism to the JSOG 2024 criteria would enhance the accuracy of PCOS diagnosis and enhance consistency with the Rotterdam 2003 criteria. Measuring basal LH level is useful for assessing the endocrinologic characteristics of Japanese PCOS cases, as well as lean Asian PCOS cases, but the timing of blood sampling can affect the result.

    DOI PubMed

  • Microbiological investigation of pregnancies following vaginal radical trachelectomy using 16S rRNA sequencing of FFPE placental specimens.

    Risa Tsunematsu, Tasuku Mariya, Mina Umemoto, Shiori Ogawa, Wataru Arai, Suguru E Tanaka, Kyota Ashikawa, Terufumi Kubo, Yoshiyuki Sakuraba, Tsuyoshi Baba, Shinichi Ishioka, Toshiaki Endo, Tsuyoshi Saito

    FEBS open bio    2024年09月  [国際誌]

    　概要を見る

    This study examined the risk of intrauterine infection associated with radical trachelectomy (RT) in early-stage cervical cancer patients. This procedure preserves fertility but is linked to increased risk of intrauterine infection due to cervical defects during pregnancy. DNA was extracted from the formalin-fixed paraffin-embedded (FFPE) placental specimens of 23 pregnant post-RT patients and 16S rRNA gene sequencing was used for bacterial identification. The prevalence of Lactobacillus crispatus and Burkholderia stabilis was significantly higher in the non-chorioamnionitis group. In contrast, alpha diversity analysis using the PD index showed significantly higher diversity in the chorioamnionitis group (P = 0.04). The demonstrated relationship between chorioamnionitis and microbial diversity affirms the importance of controlling the genital bacterial flora in pregnancies following RT.

    DOI PubMed

  • IB3期の子宮頸癌に対して術前化学療法後に広汎子宮頸部摘出術を施行し分娩となった1例

    佐藤 冴子, 染谷 真行, 玉手 雅人, 松浦 基樹, 森下 美幸, 馬場 剛, 石岡 伸一, 齋藤 豪

    北日本産科婦人科学会総会・学術講演会プログラム・抄録集 ( 東北連合産科婦人科学会・北日本産科婦人科学会 )  71回   48 - 48  2024年09月

  • Cut-off value for anti-Müllerian hormone in the diagnostic criteria for polycystic ovary syndrome in the Japanese population.

    Hiroki Noguchi, Takeshi Iwasa, Akira Iwase, Haruhiko Kanasaki, Fuminori Kimura, Koji Kugu, Kazuki Saito, Tsuyoshi Baba, Tetsuaki Hara, Toshiya Matsuzaki

    The journal of obstetrics and gynaecology research    2024年06月  [国際誌]

    　概要を見る

    AIM: To establish cut-off values for anti-Müllerian hormone (AMH) and antral follicle count (AFC) in the diagnostic criteria for polycystic ovary syndrome (PCOS) applicable to the Japan Society of Obstetrics and Gynecology (JSOG) 2024 criteria and the Rotterdam/International Evidence-Based Guideline for the assessment and management of PCOS (IEBG) 2023 criteria based on a nationwide survey, respectively, taking into account age, assays, and structure of the diagnostic criteria. METHODS: Data were collected for 986 PCOS cases and 965 control cases using a national survey in Japan and used to establish cut-off values for AMH and AFC. RESULTS: Serum AMH levels were significantly higher in the PCOS group compared to the control group. Serum AMH showed a significant negative correlation with age and significant positive correlation with AFC in both groups. In multiple regression analysis, serum AMH level was independently affected by AFC and total testosterone. AMH cut-off values suitable for the JSOG 2024 criteria and the Rotterdam/IEBG 2023 criteria were separately established for the 20-29 and 30-39 years of age groups, respectively, and for Access, Lumipulse and Elecsys/ECLusys, respectively. AFC cut-off values suitable for the JSOG 2024 criteria and Rotterdam/IEBG 2023 criteria were also established separately. AFC exhibited statistically greater variability than AMH. CONCLUSION: The serum AMH level is the biochemical representation of ovarian findings in PCOS and considered objective and highly reliable. Therefore, it could serve as a surrogate for AFC as a marker of polycystic ovarian morphology in diagnostic criteria.

    DOI PubMed

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Misc 【 表示 ／ 非表示 】

  • Editor’s Focus: Maternal Alcohol Use and Fetal Growth in Japan

    Kazutoshi Cho, Sumitaka Kobayashi, Atsuko Araki, Chihiro Miyashita, Sachiko Itoh, Yasuaki Saijo, Yoshiya Ito, Kazuo Sengoku, Tsuyoshi Baba, Hisanori Minakami, Yuichi Nakamura, Reiko Kishi, The Japan Environment and Children’s Study Group

    Pediatric Research ( Springer Science and Business Media LLC )  92 ( 1 ) 1 - 1  2022年07月  [招待有り]   [ 国際誌 ]

    記事・総説・解説・論説等（学術雑誌）  

    　概要を見る

    掲載論文（責任著者）が、Pediatric Research volume 92 No. 1 July 2022のEditor’s Focusに選出され紹介された。掲載論文：Kazutoshi Cho, Sumitaka Kobayashi, et al. Prenatal alcohol exposure and adverse fetal growth restriction: findings from the Japan Environment and Children's Study. Pediatric Research. 2022; 92: 291-298. https://doi.org/10.1038/s41390-021-01595-3.

    DOI

  • 当院における思春期前症例の卵巣組織ガラス化保存と周術期の問題点について

    馬場 剛, 玉手 雅人, 春日 芙貴子, 長尾 沙智子, 藤部 佑哉, 木井 菜摘, 君塚 基修, 齋藤 豪

    日本がん・生殖医療学会誌 ( (一社)日本がん・生殖医療学会 )  5 ( 1 ) 139 - 139  2022年01月

  • 当科における卵巣組織凍結の報告と北海道内の同技術の認識について

    古来 愛香, 玉手 雅人, 春日 芙貴子, 長尾 沙智子, 小川 万梨絵, 池田 桂子, 久野 芳佳, 森下 美幸, 馬場 剛, 齋藤 豪

    日本生殖医学会雑誌 ( (一社)日本生殖医学会 )  66 ( 4 ) 316 - 316  2021年10月

  • 月経不順を契機に診断されたトルコ鞍黄色肉芽腫の1例

    小川 万梨絵, 馬場 剛, 春日 芙貴子, 古来 愛香, 玉手 雅人, 池田 桂子, 森下 美幸, 久野 芳佳, 遠藤 俊明, 齋藤 豪

    日本生殖医学会雑誌 ( (一社)日本生殖医学会 )  66 ( 4 ) 346 - 346  2021年10月

  • 妊娠に至ったGonadotropin resistant ovaryの1症例

    久野 芳佳, 馬場 剛, 春日 芙貴子, 古来 愛香, 玉手 雅人, 小川 万梨絵, 池田 桂子, 森下 美幸, 遠藤 俊明, 齋藤 豪

    日本生殖医学会雑誌 ( (一社)日本生殖医学会 )  66 ( 4 ) 403 - 403  2021年10月

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共同研究・競争的資金等の研究課題 【 表示 ／ 非表示 】

  • 遺伝子多型は多嚢胞性卵巣症候群の疾患感受性、薬剤応答性を規定する

    若手研究(B)

    研究期間:

    2008年
    -
    2010年
     

    馬場 剛

    　研究概要を見る

    インスリン抵抗性関連遺伝子の一塩基多型(SNP)のうち、IRS-1Gly972Arg、RETN-420C/GがPCOSの疾患感受性遺伝子であることが判明した。一方、ENPP1 Lys121Gln、apM1-11377C/Gの遺伝子型頻度に関しては、PCOS症例とコントロール症例において、有意差は認められなかった。PCOS症例において、RETN homogeneous variant genotypeをもつものでは有意にBMI高値、空腹時インスリン高値、Adiponectin低値であったが、IRS-1 genotypeによる差異は認められなかった。

  • 多嚢胞性卵巣症候群におけるインスリン抵抗性

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