2025/08/22 更新

写真a

ババ ツヨシ
馬場 剛
所属
医学部 産婦人科学講座産科周産期科学分野 准教授
職名
准教授
外部リンク

学位

  • 医学博士 ( 2001年3月 )

研究分野

  • ライフサイエンス / 産婦人科学

所属学協会

▼全件表示

論文

  • Japan Society of Obstetrics and Gynecology revised diagnostic criteria for polycystic ovary syndrome: JSOG2024 criteria. 国際誌

    Hiroki Noguchi, Akira Iwase, Takeshi Iwasa, Haruhiko Kanasaki, Fuminori Kimura, Koji Kugu, Kazuki Saito, Tsuyoshi Baba, Tetsuaki Hara, Saki Minato, Rie Yanagihara, Toshiya Matsuzaki

    The journal of obstetrics and gynaecology research   51 ( 1 )   e16152   2025年1月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    Japanese patients with polycystic ovary syndrome (PCOS) exhibit distinct body type characteristics, such that the rate of overweight/obese women is remarkably low. In addition, hyperandrogenism is relatively rare among Japanese PCOS patients. Therefore, these factors are considered in PCOS diagnostic criteria used in Japan. Diagnostic criteria for PCOS were recently revised by the Japan Society of Obstetrics and Gynecology based on a nationwide survey of PCOS and released on December 5, 2023 (JSOG2024). JSOG2024 criteria diagnosed PCOS according to the following three items: (1) irregular menstrual cycle/chronic anovulation, (2) polycystic ovarian morphology or elevated serum anti-Müllerian hormone (AMH) level, and (3) hyperandrogenism or high luteinizing hormone. The presence of all three items is required to diagnose PCOS, after excluding other diseases with symptoms similar to PCOS. We also established AMH cut-off values by age and a system for evaluating ovarian findings useful for both the JSOG2024 and Rotterdam criteria. We anticipate that the JSOG2024 criteria with cut-off values will enhance the treatment of Japanese patients with PCOS and those of other ethnicities with low obesity and hirsutism.

    DOI: 10.1111/jog.16152

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  • Phenotypes and clinical laboratory data for polycystic ovary syndrome cases: A nationwide survey in Japan. 国際誌

    Hiroki Noguchi, Takeshi Iwasa, Akira Iwase, Haruhiko Kanasaki, Fuminori Kimura, Koji Kugu, Kazuki Saito, Tsuyoshi Baba, Tetsuaki Hara, Toshiya Matsuzaki

    The journal of obstetrics and gynaecology research   50 ( 12 )   2346 - 2356   2024年12月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    AIM: Describe the current phenotypes and clinical laboratory data regarding polycystic ovary syndrome (PCOS) in Japan, taking into account ethnic differences and obesity status. METHODS: Data for 986 PCOS cases and 965 control cases were collected using a nationwide survey in Japan. Obese/overweight (body mass index [BMI] ≥25 kg/m2) and non-obese/overweight (BMI <25 kg/m2) cases were compared. RESULTS: Japanese PCOS cases predominantly involved non-obese/overweight patients, accounting for 75% of all cases. Among non-obese/overweight PCOS cases, the incidence of both amenorrhea and clinical/biochemical hyperandrogenism was significantly lower than in obese/overweight PCOS cases, whereas the rate of elevated serum luteinizing hormone (LH) level was significantly higher. Even though the incidence of hirsutism in Japan is only 13.5%, the detection rate for hyperandrogenism increased by as much as 30.4% when hirsutism was added to the Japan Society of Obstetrics and Gynecology (JSOG) criteria for the diagnosis of hyperandrogenism in addition to elevated serum total testosterone level. When evaluated based on timing of blood sampling, the LH level and LH/follicle-stimulating hormone ratio determined at the initial consultation involving a chief complaint of irregular menstrual cycle (after confirming the absence of follicles measuring ≥1 cm in diameter) were significantly higher than on days 2-3 or 4-6 of the menstrual cycle. CONCLUSIONS: Ethnic differences, including obesity status, affected the phenotype and clinical laboratory data of Japanese PCOS patients, such as the incidence rates of clinical/biochemical hyperandrogenism and the rate of elevated basal LH level. Adding hirsutism to the JSOG 2024 criteria would enhance the accuracy of PCOS diagnosis and enhance consistency with the Rotterdam 2003 criteria. Measuring basal LH level is useful for assessing the endocrinologic characteristics of Japanese PCOS cases, as well as lean Asian PCOS cases, but the timing of blood sampling can affect the result.

    DOI: 10.1111/jog.16136

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  • Microbiological investigation of pregnancies following vaginal radical trachelectomy using 16S rRNA sequencing of FFPE placental specimens. 国際誌

    Risa Tsunematsu, Tasuku Mariya, Mina Umemoto, Shiori Ogawa, Wataru Arai, Suguru E Tanaka, Kyota Ashikawa, Terufumi Kubo, Yoshiyuki Sakuraba, Tsuyoshi Baba, Shinichi Ishioka, Toshiaki Endo, Tsuyoshi Saito

    FEBS open bio   2024年9月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    This study examined the risk of intrauterine infection associated with radical trachelectomy (RT) in early-stage cervical cancer patients. This procedure preserves fertility but is linked to increased risk of intrauterine infection due to cervical defects during pregnancy. DNA was extracted from the formalin-fixed paraffin-embedded (FFPE) placental specimens of 23 pregnant post-RT patients and 16S rRNA gene sequencing was used for bacterial identification. The prevalence of Lactobacillus crispatus and Burkholderia stabilis was significantly higher in the non-chorioamnionitis group. In contrast, alpha diversity analysis using the PD index showed significantly higher diversity in the chorioamnionitis group (P = 0.04). The demonstrated relationship between chorioamnionitis and microbial diversity affirms the importance of controlling the genital bacterial flora in pregnancies following RT.

    DOI: 10.1002/2211-5463.13892

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  • IB3期の子宮頸癌に対して術前化学療法後に広汎子宮頸部摘出術を施行し分娩となった1例

    佐藤 冴子, 染谷 真行, 玉手 雅人, 松浦 基樹, 森下 美幸, 馬場 剛, 石岡 伸一, 齋藤 豪

    北日本産科婦人科学会総会・学術講演会プログラム・抄録集   71回   48 - 48   2024年9月

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    記述言語:日本語   出版者・発行元:東北連合産科婦人科学会・北日本産科婦人科学会  

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  • Cut-off value for anti-Müllerian hormone in the diagnostic criteria for polycystic ovary syndrome in the Japanese population. 国際誌

    Hiroki Noguchi, Takeshi Iwasa, Akira Iwase, Haruhiko Kanasaki, Fuminori Kimura, Koji Kugu, Kazuki Saito, Tsuyoshi Baba, Tetsuaki Hara, Toshiya Matsuzaki

    The journal of obstetrics and gynaecology research   2024年6月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    AIM: To establish cut-off values for anti-Müllerian hormone (AMH) and antral follicle count (AFC) in the diagnostic criteria for polycystic ovary syndrome (PCOS) applicable to the Japan Society of Obstetrics and Gynecology (JSOG) 2024 criteria and the Rotterdam/International Evidence-Based Guideline for the assessment and management of PCOS (IEBG) 2023 criteria based on a nationwide survey, respectively, taking into account age, assays, and structure of the diagnostic criteria. METHODS: Data were collected for 986 PCOS cases and 965 control cases using a national survey in Japan and used to establish cut-off values for AMH and AFC. RESULTS: Serum AMH levels were significantly higher in the PCOS group compared to the control group. Serum AMH showed a significant negative correlation with age and significant positive correlation with AFC in both groups. In multiple regression analysis, serum AMH level was independently affected by AFC and total testosterone. AMH cut-off values suitable for the JSOG 2024 criteria and the Rotterdam/IEBG 2023 criteria were separately established for the 20-29 and 30-39 years of age groups, respectively, and for Access, Lumipulse and Elecsys/ECLusys, respectively. AFC cut-off values suitable for the JSOG 2024 criteria and Rotterdam/IEBG 2023 criteria were also established separately. AFC exhibited statistically greater variability than AMH. CONCLUSION: The serum AMH level is the biochemical representation of ovarian findings in PCOS and considered objective and highly reliable. Therefore, it could serve as a surrogate for AFC as a marker of polycystic ovarian morphology in diagnostic criteria.

    DOI: 10.1111/jog.15972

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  • 妊娠後期に急性腹症と肝酵素上昇を認め,総胆管結石として待機的管理を行った1例

    宮下 夕稀子, 染谷 真行, 真里谷 奨, 馬場 剛, 石岡 伸一, 岡村 直樹, 齋藤 豪

    日本周産期・新生児医学会雑誌   60 ( Suppl.1 )   P395 - P395   2024年6月

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    記述言語:日本語   出版者・発行元:(一社)日本周産期・新生児医学会  

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  • 妊娠中期に多量出血を伴わずに原因不明の産科DICを発症した2例

    齋藤 晋平, 染谷 真行, 真里谷 奨, 馬場 剛, 石岡 伸一, 齋藤 豪

    日本周産期・新生児医学会雑誌   60 ( Suppl.1 )   P336 - P336   2024年6月

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    記述言語:日本語   出版者・発行元:(一社)日本周産期・新生児医学会  

    医中誌

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  • 低置胎盤の分娩管理の変化と,それに伴う周産期転帰の変化について

    染谷 真行, 古来 愛香, 真里谷 奨, 馬場 剛, 石岡 伸一, 齋藤 豪

    日本周産期・新生児医学会雑誌   60 ( Suppl.1 )   P382 - P382   2024年6月

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    記述言語:日本語   出版者・発行元:(一社)日本周産期・新生児医学会  

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  • 子宮移植までのマイルストーン

    玉手 雅人, 馬場 剛, 和田 渚, 古来 愛香, 幅田 周太朗, 小川 万梨絵, 松浦 基樹, 齋藤 豪

    日本生殖医学会雑誌   69 ( 1-2 )   122 - 122   2024年4月

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    記述言語:日本語   出版者・発行元:(一社)日本生殖医学会  

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  • がん患者の妊孕性温存に関する情報提供の現状と課題

    古来 愛香, 玉手 雅人, 馬場 剛, 長尾 沙智子, 小川 万梨絵, 森下 美幸, 久野 芳佳, 齋藤 豪

    日本生殖医学会雑誌   69 ( 1-2 )   121 - 121   2024年4月

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    記述言語:日本語   出版者・発行元:(一社)日本生殖医学会  

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  • 当科における最近10年間のCesarean hysterectomy症例の検討

    齋藤 晋平, 石岡 伸一, 新開 翔太, 真里谷 奨, 染谷 真行, 小川 万梨絵, 森下 美幸, 馬場 剛, 齋藤 豪

    日本産科婦人科学会雑誌   76 ( 臨増 )   S - 592   2024年2月

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    記述言語:日本語   出版者・発行元:(公社)日本産科婦人科学会  

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  • 経過観察中に自然軽快した広汎性卵巣浮腫の2症例

    馬場 剛, 遠藤 俊明, 新開 翔太, 真里谷 奨, 染谷 真行, 森下 美幸, 岩崎 雅宏, 石岡 伸一, 齋藤 豪

    日本産科婦人科学会雑誌   76 ( 臨増 )   S - 383   2024年2月

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    記述言語:日本語   出版者・発行元:(公社)日本産科婦人科学会  

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  • 妊孕性温存療法後、胚移植に至った症例に関する検討

    久野 芳佳, 馬場 剛, 齋藤 晋平, 古来 愛香, 長尾 沙智子, 玉手 雅人, 小川 万梨絵, 森下 美幸, 遠藤 俊明, 齋藤 豪

    日本がん・生殖医療学会誌   7 ( 1 )   112 - 112   2024年1月

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    記述言語:日本語   出版者・発行元:(一社)日本がん・生殖医療学会  

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  • 当科における卵巣組織凍結の報告と北海道内の同技術の認識について

    古来 愛香, 玉手 雅人, 春日 芙貴子, 長尾 沙智子, 小川 万梨絵, 池田 桂子, 久野 芳佳, 森下 美幸, 馬場 剛, 齋藤 豪

    北海道産科婦人科学会会誌   67 ( 1 )   85 - 85   2023年12月

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    記述言語:日本語   出版者・発行元:北海道産科婦人科学会  

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  • Pregnancy-specific beta-1-glycoprotein 6 is a potential novel diagnostic biomarker of placenta accreta spectrum.

    Hazuki Kashiwagi, Tasuku Mariya, Mina Umemoto, Shiori Ogawa, Yoshihiko Hirohashi, Yuya Fujibe, Terufumi Kubo, Masayuki Someya, Tsuyoshi Baba, Shinichi Ishioka, Toshihiko Torigoe, Tsuyoshi Saito

    Medical molecular morphology   2023年10月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    Early diagnosis is essential for the safer perinatal management of placenta accreta spectrum (PAS). We used transcriptome analysis to investigate diagnostic maternal serum biomarkers and the mechanisms of PAS development. We analyzed eight formalin-fixed paraffin-embedded placental specimens from two placenta increta and three placenta percreta cases who underwent cesarean hysterectomy at Sapporo Medical University Hospital between 2013 and 2019. Invaded placental regions were isolated from the uterine myometrium and RNA was extracted. The transcriptome difference between normal placenta and PAS was analyzed by microarray analysis. The PAS group showed markedly decreased expression of placenta-specific genes such as LGALS13 and the pregnancy-specific beta-1-glycoprotein (PSG) family. Term enrichment analysis revealed changes in genes related to cellular protein catabolic process, female pregnancy, autophagy, and metabolism of lipids. From the highly dysregulated genes in the PAS group, we investigated the expression of PSG family members, which are secreted into the intervillous space and can be detected in maternal serum from the early stage of pregnancy. The gene expression level of PSG6 in particular was progressively decreased from placenta increta to percreta. The PSG family, especially PSG6, is a potential biomarker for PAS diagnosis.

    DOI: 10.1007/s00795-023-00371-y

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  • 子宮移植実現に向けた献体トレーニング

    玉手 雅人, 松浦 基樹, 長尾 沙智子, 黒川 晶子, 秋元 太志, 馬場 剛, 齋藤 豪

    Organ Biology   30 ( 3 )   111 - 111   2023年10月

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    記述言語:日本語   出版者・発行元:(一社)日本臓器保存生物医学会  

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  • Endocrinological and Metabolic Heterogeneity is low in Japanese Women with Polycystic Ovary Syndrome. 国際誌

    Tsuyoshi Baba, Toshiaki Endo, Tasuku Mariya, Yoshika Kuno, Hiroyuki Honnma, Mika Kanaya, Tsuyoshi Saito

    Journal of obstetrics and gynaecology Canada : JOGC = Journal d'obstetrique et gynecologie du Canada : JOGC   102217 - 102217   2023年9月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    OBJECTIVE: This study aims to evaluate the endocrine differences among polycystic ovary syndrome (PCOS) phenotypes in Japanese women. METHODS: 118 Japanese women that we diagnosed with PCOS agreed to be included in the study. The study group was classified into the following four phenotypes: A) hyperandrogenism (HA); ovulatory disorder (OvD) and polycystic ovary morphology (PCOM); B) HA and OvD; C) HA and PCOM; and D) OvD and PCOM. We also recruited 66 healthy Japanese women to the study as control participants. Age, body mass index, androgens, luteinizing hormone, follicle-stimulating hormone, and insulin resistance index were evaluated and compared. RESULTS: The proportions of phenotypes A, B, C, and D were 57/120 (47.5%), 4/120 (3.3%), 13/120 (10.8%), and 46/120 (38.3%), respectively. The proportion of phenotype B was too small; therefore, phenotypes A and B were grouped as classical PCOS for intergroup comparisons. The luteinizing hormone/follicle-stimulating hormone ratio in the classical PCOS group was higher than that in the phenotype D group (P < 0.001). Androgen concentrations in the phenotype D group were significantly lower than those in the other groups (P < 0.01). Phenotype D was more common in lean women with PCOS. The surrogate marker of insulin resistance (homeostasis model assessment of insulin resistance (HOMA-IR)) was not different irrespective of PCOS and its phenotypes. CONCLUSION: Except for androgens, endocrine differences by PCOS phenotype are not evident, suggesting that diversity among patients with PCOS is relatively low in Japanese women.

    DOI: 10.1016/j.jogc.2023.102217

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  • 当科における卵巣組織凍結の現状報告と北海道における小児科医の卵巣組織凍結に対する意識調査

    長尾 沙智子, 玉手 雅人, 春日 芙貴子, 西村 庸子, 松浦 基樹, 久野 芳佳, 馬場 剛, 齋藤 豪

    日本婦人科腫瘍学会学術講演会プログラム・抄録集   65回   387 - 387   2023年7月

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    記述言語:日本語   出版者・発行元:(公社)日本婦人科腫瘍学会  

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  • 巨大腺筋症に対する開腹子宮頸管縫縮術を施行し,救命可能週数まで妊娠継続できた一絨毛膜二羊膜双胎の1例

    常松 梨紗, 石岡 伸一, 馬場 剛, 真里谷 奨, 染谷 真行, 新開 翔太, 齋藤 豪

    日本周産期・新生児医学会雑誌   59 ( Suppl.1 )   P322 - P322   2023年6月

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    記述言語:日本語   出版者・発行元:(一社)日本周産期・新生児医学会  

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  • 不育症カップルがPGT-SR受検を決定する因子と意思決定支援に求められる遺伝カウンセリングのあり方についての検討

    久々宇 千恵, 石川 亜貴, 真里谷 奨, 馬場 剛, 遠藤 俊明, 櫻井 晃洋

    日本遺伝カウンセリング学会誌   44 ( 2 )   155 - 155   2023年6月

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    記述言語:日本語   出版者・発行元:(一社)日本遺伝カウンセリング学会  

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  • Aggressive angiomyxoma(AAM)合併妊娠の一例

    古来 愛香, 石岡 伸一, 新開 翔太, 常松 梨紗, 真里谷 奨, 染谷 真行, 松浦 基樹, 馬場 剛, 齋藤 剛

    日本周産期・新生児医学会雑誌   59 ( Suppl.1 )   P438 - P438   2023年6月

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    記述言語:日本語   出版者・発行元:(一社)日本周産期・新生児医学会  

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  • 均衡型染色体転座に対するPGT-SRを実施した当院症例の解析結果から考察する遺伝カウンセリング時の適正な情報提供について

    葛西 彩乃, 真里谷 奨, 石川 亜貴, 馬場 剛, 遠藤 俊明, 尾崎 守, 櫻井 晃洋

    日本遺伝カウンセリング学会誌   44 ( 2 )   133 - 133   2023年6月

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    記述言語:日本語   出版者・発行元:(一社)日本遺伝カウンセリング学会  

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  • Clinical application of long-read nanopore sequencing in a preimplantation genetic testing pre-clinical workup to identify the junction for complex Xq chromosome rearrangement-related disease. 国際誌

    Tasuku Mariya, Yui Shichiri, Takeshi Sugimoto, Rie Kawamura, Syunsuke Miyai, Hidehito Inagaki, Eiji Sugihara, Keiko Ikeda, Tsuyoshi Baba, Aki Ishikawa, Michiko Ammae, Yoshiharu Nakaoka, Tsuyoshi Saito, Akihiro Sakurai, Hiroki Kurahashi

    Prenatal diagnosis   43 ( 3 )   304 - 313   2023年2月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    OBJECTIVE: Xq chromosome duplication with complex rearrangements is generally acknowledged to be associated with neurodevelopmental disorders such as Pelizaeus-Merzbacher disease (PMD) and MECP2 duplication syndrome. For couples who required a PGT-M (pre-implantation genetic testing for monogenic disease) for these disorders, junction-specific PCR is useful to directly detect pathogenic variants. Therefore, pre-clinical workup for PGT-M requires the identification of the junction of duplicated segments in PMD and MECP2 duplication syndrome, which is generally difficult. METHODS: In this report, we used nanopore long-read sequencing targeting the X chromosome using an adaptive sampling method to identify breakpoint junctions in disease-causing triplications. RESULTS: By long-read sequencing, we successfully identified breakpoint junctions in one PMD case with PLP1 triplication and in another MECP2 triplication case in a single sequencing run. Surprisingly, the duplicated region involving MECP2 was inserted 45 Mb proximal to the original position. This inserted region was confirmed by FISH analysis. With the help of precise mapping of the pathogenic variant, we successfully re-established STR haplotyping for PGT-M and avoided any potential misinterpretation of the pathogenic allele due to recombination. CONCLUSION: Long-read sequencing with adaptive sampling in a PGT-M pre-clinical workup is a beneficial method for identifying junctions of chromosomal complex structural rearrangements. This article is protected by copyright. All rights reserved.

    DOI: 10.1002/pd.6334

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  • 当科における卵巣組織凍結の現状報告と北海道における小児科医の卵巣組織凍結に対する意識調査

    古来 愛香, 玉手 雅人, 春日 芙貴子, 長尾 沙智子, 西村 庸子, 松浦 基樹, 久野 芳佳, 馬場 剛, 齋藤 豪

    日本がん・生殖医療学会誌   6 ( 1 )   49 - 53   2023年2月

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    記述言語:日本語   出版者・発行元:(一社)日本がん・生殖医療学会  

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  • 中心核ミオパチーの児出産を契機に発見された1型リアノジン受容体(RYR1)遺伝子のバリアントを有する妊婦の一例

    古来 愛香, 石岡 伸一, 新開 翔太, 真里谷 奨, 常松 梨紗, 染谷 真行, 小川 万梨絵, 森下 美幸, 馬場 剛, 齋藤 豪

    日本産科婦人科学会雑誌   75 ( 臨増 )   S - 459   2023年2月

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    記述言語:日本語   出版者・発行元:(公社)日本産科婦人科学会  

    医中誌

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  • 中心核ミオパチーの児出産を契機に発見された1型リアノジン受容体(RYR1)遺伝子のバリアントを有する妊婦の一例

    古来 愛香, 石岡 伸一, 新開 翔太, 真里谷 奨, 常松 梨紗, 染谷 真行, 小川 万梨絵, 森下 美幸, 馬場 剛, 齋藤 豪

    日本産科婦人科学会雑誌   75 ( 臨増 )   S - 459   2023年2月

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    記述言語:日本語   出版者・発行元:(公社)日本産科婦人科学会  

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  • Letrozole increases preantral follicle growth and decreases estradiol production without impairing follicle survival. 国際誌

    Fukiko Kasuga-Yamashita, Tsuyoshi Baba, Sachiko Nagao, Yuya Fujibe, Miyuki Morishita, Yoshika Kuno, Tasuku Mariya, Hiroyuki Honnma, Toshiaki Endo, Tamotsu Kiya, Tsuyoshi Saito

    Journal of ovarian research   15 ( 1 )   136 - 136   2022年12月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    BACKGROUND: Letrozole has been reported to be effective in treating anovulation, preventing ovarian hyperstimulation syndrome (OHSS), and retrieving oocytes in breast cancer patients. However, the role and mechanism of letrozole in follicular development remain unclear. RESULTS: We treated mouse preantral follicles with various treatments; we found no significant difference in follicle survival rates in the letrozole (LET) group compared with the control group, but the average diameter of follicles in the LET group tended to be larger (CTRL vs. LET 30, p = 0.064; CTRL vs. LET 100, p = 0.025). The estradiol concentrations in culture media of the LET group were significantly lower than those observed in the control group (CTRL vs. LET 30, p = 0.038; CTRL vs. LET 100, p = 0.025). We further found a marked increase in follicle-stimulating hormone receptor (FSHR) gene expression in response to letrozole treatment (CTRL vs. LET 30, p = 0.075; CTRL vs. LET 100, p = 0.034). This result suggested that increased FSHR expression promotes follicle development. Letrozole inhibited aromatase activity, but the effect was limited. Letrozole did not significantly reduce vascular endothelial growth factor (VEGF) gene expression. CONCLUSIONS: Letrozole may promote follicle development by increasing the expression of FSHR. Letrozole may be useful for fertility preservation of patients with estrogen-dependent cancers such as breast cancer and various other cancers. Whether letrozole has a direct effect in reducing OHSS requires further investigation.

    DOI: 10.1186/s13048-022-01073-2

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  • Self-administration of gender-affirming hormones and supratherapeutic dosing are relatively common in Japanese transgender women. 国際誌

    Tsuyoshi Baba, Toshiaki Endo, Utako Ikeda, Hiroshi Ikeda, Koji Ichihara, Naoya Masumori, Tsuyoshi Saito

    The journal of obstetrics and gynaecology research   48 ( 8 )   2208 - 2213   2022年8月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    AIM: This study was performed to determine the proportion of transgender women with self-adjusted hormone administration and excess dosing. METHODS: The medical records of 87 transgender women who visited our gender clinic from 2010 through 2019 were reviewed. The complete blood count and serum concentrations of D-dimer, gonadotropins, and sex steroids were compared between transgender women who were self-administering gender-affirming hormones and women not using such hormones. RESULTS: Fifty-eight of 87 (66.7%) transgender women had contravened the guideline and self-adjusted their hormone administration. The hormonal data of one woman with hypopituitarism were eliminated from the analyses. The serum gonadotropin and testosterone levels were significantly lower in the self-administration group than in the hormone-naïve group. Gonadotropin levels below the lower limit of normal were found in 32/86 (37.2%) transgender women. The testosterone levels in six transgender women were not analyzed because these women had undergone sex reassignment surgery before visiting our hospital. Testosterone levels below the lower limit of normal men were found in 36/80 (45.0%) transgender women. Unexpectedly, 29/36 (80.6%) transgender women who were classified as having suppressed serum testosterone levels had testosterone levels of <0.6 ng/mL, which corresponds to the levels in cisgender women. The white blood cell count and hemoglobin concentration were significantly different between the groups. CONCLUSION: Self-initiated hormonal treatments seem to affect the serum concentrations of gonadotropin and sex steroids and the complete blood count. The prevalence of transgender women with self-adjusted use of gender-affirming hormones is high, and an excess dose of hormones occasionally occurs.

    DOI: 10.1111/jog.15231

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  • 児の緩和的対応を前提とした新生児予後不良な妊娠における,適切な医療体制について

    染谷 真行, 古来 愛香, 真里谷 奨, 馬場 剛, 石岡 伸一, 齋藤 豪

    日本周産期・新生児医学会雑誌   58 ( Suppl.1 )   310 - 310   2022年6月

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    記述言語:日本語   出版者・発行元:(一社)日本周産期・新生児医学会  

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  • 妊娠中の脳腫瘍に対し,周期的なテモゾロミド投与を行った一例

    齋藤 晋平, 古来 愛香, 真里谷 奨, 馬場 剛, 石岡 伸一, 齋藤 豪

    日本周産期・新生児医学会雑誌   58 ( Suppl.1 )   323 - 323   2022年6月

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    記述言語:日本語   出版者・発行元:(一社)日本周産期・新生児医学会  

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  • 当科における分娩時hysterectomy症例の検討

    石岡 伸一, 染谷 真行, 柏木 葉月, 藤部 佑哉, 真里谷 奨, 馬場 剛, 斎藤 豪

    日本周産期・新生児医学会雑誌   58 ( Suppl.1 )   297 - 297   2022年6月

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    記述言語:日本語   出版者・発行元:(一社)日本周産期・新生児医学会  

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  • 液体クロマトグラフィー・タンデム質量分析(LC-MS/MS)法にて診断した偽性高テストステロン血症の一例

    小川 万梨絵, 馬場 剛, 春日 芙貴子, 玉手 雅人, 池田 桂子, 森下 美幸, 久野 芳佳, 遠藤 俊明, 齋藤 豪

    北海道産科婦人科学会会誌   66 ( 1 )   55 - 58   2022年3月

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    記述言語:日本語   出版者・発行元:北海道産科婦人科学会  

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  • CD138免疫染色と子宮内microbiotaのcombined testに子宮内pH測定を加えた慢性子宮内膜炎の病態整理

    遠藤 俊明, 池田 詩子, 逸見 博文, 本間 寛之, 木谷 保, 真里谷 奨, 久野 芳佳, 馬場 剛, 山田 秀人, 東口 篤司, 藤井 美穂, 齋藤 豪

    日本産科婦人科学会雑誌   74 ( 臨増 )   S - 359   2022年2月

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    記述言語:日本語   出版者・発行元:(公社)日本産科婦人科学会  

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  • 胎児超音波にて屈曲肢骨異形成症を疑い,胎盤絨毛の遺伝子検査で診断確定した一例

    小川 万梨絵, 寺本 瑞絵, 染谷 真行, 石堂 茉泉, 新開 翔太, 真里谷 奨, 池田 桂子, 森下 美幸, 久野 芳佳, 馬場 剛, 石岡 伸一, 齋藤 豪

    日本産科婦人科学会雑誌   74 ( 臨増 )   S - 374   2022年2月

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  • Guidelines for Reproductive Medicine in Japan.

    Mitsutoshi Yamada, Tomonori Ishikawa, Takeshi Iwasa, Hajime Oishi, Satoko Osuka, Kenji Oka, Shuichi Ono, Masanori Ono, Makoto Orisaka, Haruhiko Kanasaki, Yasushi Kawano, Kazuhiro Kawamura, Hiroshi Kishi, Fuminori Kimura, Shinnosuke Kuroda, Akira Kuwahara, Hideyuki Kobayashi, Akira Komiya, Hidekazu Saito, Kenji Sato, Suguru Sato, Koji Shiraishi, Hiromitsu Shirasawa, Tatsuya Suzuki, Yasushi Takai, Seido Takae, Toshifumi Takahashi, Tsuyoshi Takiuchi, Masahito Tachibana, Isao Tamura, Hiroshi Tamura, Seung Chik Jwa, Tsuyoshi Baba, Miyuki Harada, Tetsuya Hirata, Atsushi Fukui, Yusuke Fukuda, Shinichiro Fukuhara, Tetsuo Maruyama, Yasushi Yumura, Osamu Yoshino, Yasushi Hirota, Akira Tsujimura, Naoaki Kuji, Yutaka Osuga

    Reproductive medicine and biology   21 ( 1 )   e12483   2022年

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    記述言語:英語  

    DOI: 10.1002/rmb2.12483

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  • PGT-SRの結果とStengel-R法による主たる不均衡型転座の予測との一致率

    遠藤 俊明, 馬場 剛, 久野 芳佳, 池田 詩子, 本間 寛之, 逸見 博文, 稲木 誠, 原 鐵晃, 尾崎 守, 倉橋 浩樹, 斎藤 豪

    日本IVF学会誌   24 ( 2 )   60 - 60   2021年9月

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    記述言語:日本語   出版者・発行元:(一社)日本IVF学会  

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  • Prenatal alcohol exposure and adverse fetal growth restriction: findings from the Japan Environment and Children's Study. 国際誌

    Kazutoshi Cho, Sumitaka Kobayashi, Atsuko Araki, Chihiro Miyashita, Sachiko Itoh, Yasuaki Saijo, Yoshiya Ito, Kazuo Sengoku, Tsuyoshi Baba, Hisanori Minakami, Yuichi Nakamura, Reiko Kishi

    Pediatric research   92 ( 1 )   291 - 298   2021年6月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    BACKGROUNDS: Japanese studies on the association between maternal alcohol consumption and fetal growth are few. This study assessed the effect of maternal alcohol consumption on fetal growth. METHODS: This prospective birth cohort included 95,761 participants enrolled between January 2011 and March 2014 in the Japan Environment and Children's Study. Adjusted multiple linear and logistic regression models were used to assess the association between prenatal alcohol consumption and infant birth size. RESULTS: Consumption of a weekly dose of alcohol in the second/third trimester showed a significant negative correlation with standard deviation (SD; Z) scores for body weight, body length, and head circumference at birth, respectively. Consumption of a weekly dose of alcohol during the second/third trimester had a significant positive correlation with incidences of Z-score ≤ -1.5 for birth head circumference. Associations between alcohol consumption in the second/third trimester and Z-score ≤ -1.5 for birth weight or birth length were not significant. Maternal alcohol consumption in the second/third trimester above 5, 20, and 100 g/week affected body weight, body length, and head circumference at birth, respectively. CONCLUSION: Low-to-moderate alcohol consumption during pregnancy might affect fetal growth. Public health policies for pregnant women are needed to stop alcohol consumption during pregnancy. IMPACT: This study examined the association between maternal alcohol consumption and fetal growth restriction in 95,761 pregnant Japanese women using the prospective birth cohort. Maternal alcohol consumption in the second/third trimester more than 5, 20, and 100 g/week might affect fetal growth in body weight, body length, and head circumference, respectively. The findings are relevant and important for educating pregnant women on the adverse health effects that prenatal alcohol consumptions have on infants.

    DOI: 10.1038/s41390-021-01595-3

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  • What is the most anticipated change induced by treatment using gender-affirming hormones in individuals with gender incongruence? 国際誌

    Naoya Masumori, Tsuyoshi Baba, Teruo Abe, Koji Niwa

    International journal of urology : official journal of the Japanese Urological Association   28 ( 5 )   526 - 529   2021年5月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    OBJECTIVES: To identify the most eagerly anticipated change resulting from hormone therapy using gender-affirming hormones for patients with gender incongruence undergoing a clinical trial. METHODS: Patients diagnosed with gender identity disorders based on the International Classification of Diseases 10th revision classification at three institutions in Japan for whom hormone therapy using gender-affirming hormones was initiated were analyzed. They were asked what the most anticipated change was due to gender-affirming hormone that they had thought of between giving informed consent and the first administration of the drug. RESULTS: The responders were 336 transgender men who were administered androgens and 48 transgender women who received estrogens. The median age at commencement of hormone therapy was 24 years for transgender men and 28 years for transgender women. For transgender men, the most frequent answer was cessation of menses (52.7%) followed by a deepened voice (32.4%). For transgender women, breast development (35.4%) was the most anticipated change, followed by gynoid fat deposition (29.2%). CONCLUSIONS: Cessation of menses in transgender men and breast development/gynoid fat deposition in transgender women might represent primary end-points in clinical trials evaluating the efficacy of hormonal treatment in these patients.

    DOI: 10.1111/iju.14499

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  • Mediating Factors Between Parental Socioeconomic Status and Small for Gestational Age in Infants: Results from the Hokkaido Study on Environment and Children's Health. 国際誌

    Naomi Tamura, Tomoyuki Hanaoka, Kumiko Ito, Atsuko Araki, Chihiro Miyashita, Sachiko Ito, Sumitaka Kobayashi, Yoichi Ito, Hisanori Minakami, Kazutoshi Cho, Toshiaki Endo, Tsuyoshi Baba, Kazuo Sengoku, Toshinobu Miyamoto, Katsuhiko Ogasawara, Reiko Kishi

    Maternal and child health journal   25 ( 4 )   645 - 655   2021年4月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    DOI: 10.1007/s10995-020-03035-w

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  • 早産期の誘発分娩により帝王切開を回避し得たタナトフォリック骨異形成症の1例

    佐藤 由梨, 染谷 真行, 長尾 沙智子, 新開 翔太, 真里谷 奨, 森下 美幸, 馬場 剛, 石岡 伸一, 齋藤 豪

    北海道産科婦人科学会会誌   65 ( 1 )   85 - 85   2021年3月

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    記述言語:日本語   出版者・発行元:北海道産科婦人科学会  

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  • 高次施設における帝王切開率抑制の試み

    染谷 真行, 新開 翔太, 真里谷 奨, 小川 万梨絵, 森下 美幸, 馬場 剛, 石岡 伸一, 齋藤 豪

    日本産科婦人科学会雑誌   73 ( 臨増 )   S - 367   2021年3月

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    記述言語:日本語   出版者・発行元:(公社)日本産科婦人科学会  

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  • PSGファミリーの異常浸潤性胎盤診断バイオマーカーとしての可能性

    柏木 葉月, 真里谷 奨, 新開 翔太, 染谷 真行, 小川 万梨絵, 森下 美幸, 馬場 剛, 石岡 伸一, 齋藤 豪

    日本産科婦人科学会雑誌   73 ( 臨増 )   S - 611   2021年3月

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    記述言語:日本語   出版者・発行元:(公社)日本産科婦人科学会  

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  • 開腹子宮頸部縫縮術(TAC)後妊娠初期流産症例に対するmethotrexate(MTX)療法の一例

    石堂 茉泉, 石岡 伸一, 藤部 佑哉, 鈴木 美紀, 嶋田 浩志, 真里谷 奨, 馬場 剛, 齋藤 豪

    日本周産期・新生児医学会雑誌   56 ( 1 )   198 - 202   2020年5月

  • 若手産婦人科医の腹腔鏡手技トレーニングにおけるタイムトライアルの有用性の検討

    長尾 沙智子, 玉手 雅人, 藤部 佑哉, 西村 庸子, 松浦 基樹, 寺本 瑞絵, 馬場 剛, 齋藤 豪

    北海道産科婦人科学会会誌   64 ( 1 )   102 - 102   2020年3月

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    記述言語:日本語   出版者・発行元:北海道産科婦人科学会  

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  • 子宮内膜症及び腺筋症の合併が癒着胎盤を呈した妊娠の1例

    蛯谷 由真, 藤部 佑哉, 真里谷 奨, 水柿 祐子, 川俣 あかり, 水内 将人, 森下 美幸, 馬場 剛, 石岡 伸一, 菅原 太郎, 杉田 真太郎, 長谷川 匡, 齋藤 豪

    北海道産科婦人科学会会誌   64 ( 1 )   114 - 114   2020年3月

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    記述言語:日本語   出版者・発行元:北海道産科婦人科学会  

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  • 当院で出生した先天性疾患児の出生前診断状況および遺伝学的対応に関する検討

    真里谷 奨, 斉藤 公仁, 水柿 祐子, 藤部 佑哉, 川俣 あかり, 水内 将人, 森下 美幸, 馬場 剛, 水上 都, 石川 亜貴, 石岡 伸一, 櫻井 晃洋, 齋藤 豪

    北海道産科婦人科学会会誌   64 ( 1 )   108 - 108   2020年3月

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    記述言語:日本語   出版者・発行元:北海道産科婦人科学会  

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  • Prune Belly Syndromeの女児が出生後に総排泄腔遺残も疑われた1例

    藤部 佑哉, 真里谷 奨, 蛯谷 由真, 水柿 祐子, 川俣 あかり, 水内 将人, 森下 美幸, 馬場 剛, 石岡 伸一, 長岡 由修, 石郷岡 哲郎, 齋藤 豪

    北海道産科婦人科学会会誌   64 ( 1 )   108 - 109   2020年3月

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    記述言語:日本語   出版者・発行元:北海道産科婦人科学会  

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  • Pioglitazone suppresses excessive follicular development in murine preantral follicles. 国際誌

    Sachiko Nagao, Tsuyoshi Baba, Yuya Fujibe, Sayaka Adachi, Keiko Ikeda, Miyuki Morishita, Yoshika Kuno, Hiroyuki Honnma, Toshiaki Endo, Tamotsu Kiya, Tsuyoshi Saito

    Journal of ovarian research   12 ( 1 )   82 - 82   2019年8月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    Polycystic ovary syndrome (PCOS) is an endocrine disease that is common in women in their reproductive period. Patients with this disease suffer from anovulation and hyperandrogenism. Ovulation induction with exogenous gonadotropin often causes ovarian hyperstimulation syndrome because many small antral follicles pause in their growth. Treatment with insulin sensitizers is reportedly effective for both anovulation associated with PCOS, and suppression of excessive follicular growth; however, the underlying mechanism of action remains unknown. Although pioglitazone is known as an insulin sensitizer, it also has a potent modulator of cell growth and apoptosis irrespective of insulin resistance. To clarify the effect of pioglitazone on follicular growth, we performed in vitro culture of murine preantral follicles. Secondary follicles (100-160 μm in diameter) isolated from 6-week-old ICR mice were individually cultured for 13 days. Culture conditions were as follows: 1) follicle-stimulating hormone (FSH; 33 mIU/mL; control), 2) FSH plus dihydrotestosterone (DHT; 500 ng/mL), 3) FSH plus pioglitazone (5 ng/mL), and 4) FSH plus DHT/pioglitazone. Survival rate and follicle diameter were evaluated, and concentrations of estradiol (E2) and vascular endothelial growth factor (VEGF) in culture media were measured. mRNA expression of various growth-promoting factors and Vegf within follicles were also assessed. Although no significant differences were observed with regard to survival rate, follicle diameters on day 13 were significantly different.Compared with the control group, the DHT group showed enhanced growth, while groups administered pioglitazone showed stagnation of the accelerated growth induced by DHT. Although DHT treatment enhanced the expression of bone morphogenetic protein 2 (Bmp2) mRNA, pioglitazone exposure suppressed induction of Bmp2 mRNA by DHT. Vegf mRNA and protein expression were also significantly reduced when pioglitazone was added to culture media containing DHT.Administration of pioglitazone negatively affected follicular growth and VEGF levels, which may suppress excessive follicular growth and prevent ovarian hyperstimulation syndrome.

    DOI: 10.1186/s13048-019-0556-7

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  • 重症子宮内膜症を有する不妊治療における手術とART介入のタイミング

    森下 美幸, 長尾 沙智子, 新開 翔太, 久野 芳佳, 真里谷 奨, 馬場 剛, 遠藤 俊明, 齋藤 豪

    日本産科婦人科内視鏡学会雑誌   35 ( Suppl.I )   252 - 252   2019年8月

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    記述言語:日本語   出版者・発行元:(一社)日本産科婦人科内視鏡学会  

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  • Obstetrical prognosis of patients who underwent vaginal radical trachelectomy during pregnancy. 国際誌

    Mina Umemoto, Shinichi Ishioka, Yuko Mizugaki, Yuya Fujibe, Tasuku Mariya, Akari Kawamata, Masahito Mizuuchi, Miyuki Morishita, Tsuyoshi Baba, Tsuyoshi Saito

    The journal of obstetrics and gynaecology research   45 ( 6 )   1167 - 1172   2019年6月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    AIM: Radical trachelectomy (RT) with pelvic lymphadenectomy has become an option for young patients with early invasive uterine cervical cancer who decide to maintain their fertility. However, this operative method entails a high risk for the following pregnancy due to its radicality. Therefore, RT for pregnant patients can be a challenge both for gynecologic oncologists and obstetricians. METHODS: We have performed vaginal RT for five pregnant patients with uterine cervical cancer stage 1B1 according to the method of Dargent et al. The operations were performed between 16 and 26 weeks of pregnancy, and the patients were followed up carefully according to the follow-up methods we reported previously. RESULTS: Vaginal RT was performed for five patients without any troubles. Four of the patients continued their pregnancies until almost 34 weeks or longer under our previously published follow-up schedule. The pregnancy of one patient was terminated at 26 weeks due to recurrence of the cancer. CONCLUSION: Expansion of vaginal RT for pregnant patients with uterine cervical cancer could be a practical option for pregnant patients with early invasive uterine cervical cancer.

    DOI: 10.1111/jog.13964

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  • Androgen potentiates the expression of FSH receptor and supports preantral follicle development in mice. 国際誌

    Yuya Fujibe, Tsuyoshi Baba, Sachiko Nagao, Sayaka Adachi, Keiko Ikeda, Miyuki Morishita, Yoshika Kuno, Masahiro Suzuki, Masahito Mizuuchi, Hiroyuki Honnma, Toshiaki Endo, Tsuyoshi Saito

    Journal of ovarian research   12 ( 1 )   31 - 31   2019年4月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    Hyperandrogenism is one of the cardinal symptoms in polycystic ovary syndrome and plays a key role in the pathogenesis of polycystic ovary syndrome. However, the precise effects and mechanisms of excess androgen during follicular development are still unclear. Here we investigated the effects of androgen on mouse follicle development in vitro. Androgen did not affect the growth of follicles smaller than 160-180 μm in the presence of follicle-stimulating hormone (FSH). However, in the presence of low FSH, androgen supported the growth of follicles larger than 160-180 μm, a size at which growing follicles acquire FSH-dependency. Androgen did not change the mRNA expression of various growth-promoting factors but did increase mRNA expression of the FSH receptor. We suggest that androgen has a positive impact on follicle development by augmentation of the actions of FSH. Therefore, FSH-responsive but FSH-independent follicles grow in the presence of a certain level of FSH or androgen, and androgen compensates for FSH deficiency in FSH-dependent follicles.

    DOI: 10.1186/s13048-019-0505-5

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  • Association Between Maternal Serum Folate Concentrations in the First Trimester and the Risk of Birth Defects: The Hokkaido Study of Environment and Children's Health 査読 国際誌

    Kumiko Ito, Tomoyuki Hanaoka, Naomi Tamura, Seiko Sasaki, Chihiro Miyashita, Atsuko Araki, Sachiko Ito, Hisanori Minakami, Kazutoshi Cho, Toshiaki Endo, Tsuyoshi Baba, Toshinobu Miyamoto, Kazuo Sengoku, Akiko Tamakoshi, Reiko Kishi

    JOURNAL OF EPIDEMIOLOGY   29 ( 4 )   164 - 171   2019年4月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    DOI: 10.2188/jea.JE20170185

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  • 自然消失した子宮動脈仮性動脈瘤の超音波パワードップラー法所見の変化

    嶋田 浩志, 野藤 五沙, 鈴木 美紀, 幅田 周太朗, 藤部 佑哉, 水内 将人, 馬場 剛, 石岡 伸一, 齋藤 豪

    超音波医学   46 ( Suppl. )   S719 - S719   2019年4月

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    記述言語:日本語   出版者・発行元:(公社)日本超音波医学会  

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  • The roles of metformin and pravastatin on Placental endoplasmic reticulum stress and Placental growth factor in human villous-like trophoblastic BeWo cells

    Masahiro Suzuki, Masahito Mizuuchi, Tsuyoshi Baba, Yuya Fujibe, Yoshihiko Ino, Shinichi Ishioka, Tsuyoshi Saito

    Sapporo Medical journal   87 ( 1-6 )   75 - 84   2018年12月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)   出版者・発行元:Sapporo Medical University  

    DOI: 10.15114/smj.87.75

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  • Rare case of occult testosterone-producing ovarian tumor that was diagnosed by selective venous hormone sampling.

    Yoshika Kuno, Tsuyoshi Baba, Takafumi Kuroda, Mizue Teramoto, Naoki Hirokawa, Toshiaki Endo, Tsuyoshi Saito

    Reproductive medicine and biology   17 ( 4 )   504 - 508   2018年10月

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    記述言語:英語  

    CASE: A 32 year old woman was referred because of secondary amenorrhea, hirsutism, and voice deepening. OUTCOME: The blood testosterone level was markedly high. A transvaginal ultrasound revealed a small region in the left ovary, but whether or not it was a tumor was unclear. Therefore, selective ovarian venous sampling was performed. Consequently, the testosterone level was selectively increased in a blood sample that was taken from the left ovarian vein, the tumor was successfully localized, and a laparoscopic left oophorectomy was performed. Although the left ovary appeared to be normal at laparoscopy, the androgen-secreting tumor was located within it. The tumor was diagnosed as a Leydig cell tumor by histopathological analyses. CONCLUSION: This report demonstrates that selective blood sampling from ovarian veins before an operation is effective in localizing an androgen-producing ovarian tumor that is difficult to diagnose by imaging studies.

    DOI: 10.1002/rmb2.12213

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  • 2009年IOM指針に基づいた推奨妊娠中体重増加における出生児体重の検討

    嶋田 浩志, 高田 さくら, 恐神 博行, 水内 将人, 馬場 剛, 石岡 伸一, 齋藤 豪

    日本周産期・新生児医学会雑誌   54 ( 2 )   717 - 717   2018年6月

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    記述言語:日本語   出版者・発行元:(一社)日本周産期・新生児医学会  

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  • Bakriバルーンの前置胎盤・低置胎盤帝王切開症例における予防的止血効果の検討

    梅本 美菜, 黒田 敬史, 水内 将人, 野呂 薫, 柏木 葉月, 伊野 善彦, 杉田 菜穂子, 鈴木 将裕, 森下 美幸, 馬場 剛, 石岡 伸一, 齋藤 豪

    日本産婦人科・新生児血液学会誌   28 ( 1 )   30 - 31   2018年5月

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    記述言語:日本語   出版者・発行元:日本産婦人科・新生児血液学会  

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  • Pioglitazone is effective for multiple phenotyepes of the Zucker fa/fa rat with polycystc ovary morphology and insulin resistance. 国際誌

    Miyuki Morishita, Toshiaki Endo, Tsuyoshi Baba, Yoshika Kuno, Keiko Ikeda, Tamotsu Kiya, Hiroyuki Honnma, Tsuyoshi Saito

    Journal of ovarian research   11 ( 1 )   24 - 24   2018年3月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    BACKGROUND: Hyperandrogenism and insulin resistance may be related to the etiology of PCOS. Zucker fa/fa rats with polycystic ovary are obese, have insulin resistance without diabetes mellitus or hyperandrogenism and can be utilized as PCOS model rats without effects of hyperandrogenemia. PCOS patients are reported to have elevated levels of serum anti-Mullerian hormone (AMH), which has an inhibitory action on folliculogenesis, and low levels of serum adiponectin, which blocks apoptosis and induces biological effects in some tissues. Pioglitazone, an insulin sensitizer, is administered to PCOS patients with insulin resistance to induce ovulation but the mechanisms by which this occurs have not been elucidated. METHODS: We purchased 4-week-old female fatty Zucker fa/fa rats as well as lean Zucker +/+ rats for use as control rats with normal insulin sensitivity. The Zucker fa/fa rats were administered pioglitazone (2.5 mg/kg body weight/day) or a vehicle every day for 14 days in separate groups. The Zucker +/+ rats were also administered the vehicle. After 2 weeks of treatment, they were euthanized and we obtained serum samples and both ovaries and determined the body weight, ovarian weight, and serum AMH, adiponectin, testosterone, and androstenedione levels. We also examined ovarian histology to check follicle numbers by using hematoxylin-eosin staining, and the number of atretic follicles using Tdt-mediated dUTP nick end labeling (TUNEL) methods. RESULTS: The Zucker fa/fa rats used as PCO model rats and Pioglitazone treated PCO model rats were significantly heavier than the Zucker +/+ control rats (p < 0.05) at 15 day old. Pioglitazone treatment did not influence body weight or ovarian weight in either group. However, the total number of follicles was significantly larger in the PCO model rats than in the control rats (P < 0.05). Although pioglitazone treatment appeared to decrease the total number of follicles in the PCO model rats, the decrease was not statistically significant. However, pioglitazone treatment significantly decreased the total number of atretic follicles and the rate of atreteic follicles in the PCO model rats (P < 0.05). The serum AMH level was significantly higher in the PCO model rats than in the control rats. Pioglitazone treatment significantly decreased the serum AMH level and significantly increased the serum adiponectin level in the PCO model rats (P < 0.05). Serum testosterone and androstenedione levels were quite low or undetectable in the 3 groups of rats, and were not influenced by pioglitazone treatment. CONCLUSION: In this study, pioglitazone treatment reduced the serum AMH level and increased the serum adiponectin level in PCO model rats. These effects are related to reduction of the total number of atretic follicles and rate of atretic follicles. This proves that pioglitazone treatment improves healthy follicle growth in these PCO model rats with insulin resistance.

    DOI: 10.1186/s13048-018-0395-y

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  • Transabdominal cerclage (TAC) for patients with ultra-short uterine cervix after uterine cervix surgery and its impact on pregnancy 査読 国際誌

    Shinichi Ishioka, Miseon Kim, Yuko Mizugaki, Saori Kon, Kyoko Isoyama, Masahito Mizuuchi, Miyuki Morishita, Tsuyoshi Baba, Takao Sekiya, Tsuyoshi Saito

    Journal of Obstetrics and Gynaecology Research   44 ( 1 )   61 - 66   2018年1月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)   出版者・発行元:Blackwell Publishing  

    DOI: 10.1111/jog.13487

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  • Prevalence and risk of birth defects observed in a prospective cohort study: The Hokkaido study on environment and children’s health

    Tomoyuki Hanaoka, Naomi Tamura, Kumiko Ito, Seiko Sasaki, Atsuko Araki, Tamiko Ikeno, Chihiro Miyashita, Sachiko Ito, Hisanori Minakami, Kazutoshi Cho, Toshiaki Endo, Tsuyoshi Baba, Toshinobu Miyamoto, Kazuo Sengoku, Reiko Kishi, H. Goudarzi, M. Minatoya, S. Kobayashi, K. Yamazaki, S. Nishihara, Y. Ait Bamai, R. Miura, S. Kobayashi, A. Uno, S. Katoh, T. Baba, T. Yila, T. Braimoh, I. Kashino, S. Nakajima, T. Baba, Y. Saijyo, E. Yoshioka, T. Miyamoto, K. Okuyama, F. Sata, T. Kita

    Journal of Epidemiology   28 ( 3 )   125 - 132   2018年

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    DOI: 10.2188/jea.JE20160108

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  • Association of prenatal passive smoking and metabolic gene polymorphisms with child growth from birth to 3 years of age in the Hokkaido Birth Cohort Study on Environment and Children's Health 査読 国際誌

    Titilola Serifat Braimoh, Sumitaka Kobayashi, Fumihiro Sata, Seiko Sasaki, Houman Goudarzi, Thamar Ayo Yila, Atsuko Araki, Chihiro Miyashita, Hisanori Minakami, Tsuyoshi Baba, Kazuo Sengoku, Reiko Kishi

    SCIENCE OF THE TOTAL ENVIRONMENT   605   995 - 1002   2017年12月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    DOI: 10.1016/j.scitotenv.2017.06.212

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  • 当院における死戦期帝王切開を念頭においた産科救急システムの構築

    水内 将人, 藤部 佑哉, 嶋田 浩志, 馬場 剛, 石岡 伸一, 斎藤 豪

    日本周産期・新生児医学会雑誌   53 ( 2 )   727 - 727   2017年6月

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    記述言語:日本語   出版者・発行元:(一社)日本周産期・新生児医学会  

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  • Possibility of less radical treatment for patients with early invasive uterine cervical cancer 査読 国際誌

    Miseon Kim, Shinichi Ishioka, Toshiaki Endo, Tsuyoshi Baba, Masahito Mizuuchi, Sakura Takada, Tsuyoshi Saito

    JOURNAL OF OBSTETRICS AND GYNAECOLOGY RESEARCH   42 ( 7 )   876 - 882   2016年7月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    DOI: 10.1111/jog.12980

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  • Obstetrical prognosis of patients with cervical intraepithelial neoplasia (CIN) after "coin-shaped" conization. 国際誌

    Miseon Kim, Shinichi Ishioka, Toshiaki Endo, Tsuyoshi Baba, Tsuyoshi Saito

    Archives of gynecology and obstetrics   293 ( 3 )   651 - 7   2016年3月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    PURPOSE: Uterine cervical conization is related to adverse pregnancy outcomes in subsequent pregnancies. To deal with this problem, we started conservative coin-shaped conization for reproductive-aged patients with cervical intraepithelial neoplasia (CIN). Here we report both the obstetrical and oncological impacts of this operation in comparison with the standard cone-shaped resection. METHODS: A total of 401 women 44 years old or younger were treated in our hospital by CO2 laser conization between 2003 and 2012, and subsequently 50 patients became pregnant. The patients were divided into two groups, a standard cone-shaped conization group (until 2008) and a shallow coin-shaped conization group (beginning in 2008). The pregnancy courses and oncological prognoses of these two groups were studied. RESULTS: Cone height reduction of about 3 mm was done. However, there were no significant differences between the two groups with regard to the occurrence of oncological complications. In the standard conization group, 18 of the 25 patients delivered at term. In the coin-shaped conization group, 20 of the 25 patients delivered at term. There were no significant differences between the two groups with regard to the occurrence of various obstetrical complications. However, the reduction rate of cervical length over the pregnancy was smaller in the coin-shaped group and the number of patients with a short cervix length of 2 cm or less was smaller in the coin-shaped group. CONCLUSIONS: Although conservative coin-shaped conization did not markedly improve the obstetrical prognosis, this operative procedure improved the reduction rate of uterine cervical length over the pregnancy without any increase in oncological complications.

    DOI: 10.1007/s00404-015-3860-5

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  • BMI66.5kg/m2の高度肥満妊婦における帝王切開の経験

    森下 美幸, 嶋田 浩志, 馬場 剛, 石岡 伸一, 遠藤 俊明, 齋藤 豪

    産科と婦人科   83 ( 2 )   226 - 231   2016年2月

  • Successful delivery after transabdominal cerclage of uterine cervix for cervical incompetence after radical trachelectomy. 国際誌

    Shinichi Ishioka, Toshiaki Endo, Tsuyoshi Baba, Yushi Akashi, Miyuki Morishita, Asuka Sugio, Naohiro Kanayama, Tsuyoshi Saito

    The journal of obstetrics and gynaecology research   41 ( 8 )   1295 - 9   2015年8月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    Pregnancy after radical trachelectomy (RT) has a high risk of prematurity and complications such as preterm premature rupture of the membrane and chorioamnionitis. Placing a cervical cerclage at the time of RT plays an important role in preventing such obstetrical complications. In patients who have trouble with the cervical cerclage, miscarriage during the second trimester seems to be inevitable. We have therefore started preconception transabdominal cerclage (TAC) for these patients. A 36-year-old Japanese woman who had a history of miscarriage due to trouble with the nylon thread used for cerclage, successfully delivered after TAC. TAC is a useful treatment modality to prevent miscarriage for patients who have trouble with cerclage after RT.

    DOI: 10.1111/jog.12716

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  • 治療方針に苦慮した急性Stanford A型大動脈解離合併妊娠

    嶋田 浩志, 遠藤 俊明, 山本 雅恵, 杉尾 明香, 清水 亜由美, 森下 美幸, 明石 祐史, 馬場 剛, 石岡 伸一, 齋藤 豪

    北海道産科婦人科学会会誌   59 ( 1 )   22 - 26   2015年3月

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    記述言語:日本語   出版者・発行元:北海道産科婦人科学会  

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  • Importance of uterine cervical cerclage to maintain a successful pregnancy for patients who undergo vaginal radical trachelectomy 査読

    Miseon Kim, Shin-ichi Ishioka, Toshiaki Endo, Tsuyoshi Baba, Yushi Akashi, Miyuki Morishita, Hidefumi Adachi, Tsuyoshi Saito

    INTERNATIONAL JOURNAL OF CLINICAL ONCOLOGY   19 ( 5 )   906 - 911   2014年10月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    DOI: 10.1007/s10147-013-0631-9

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  • Common hypothetical etiology of excess androgen exposure in female-to-male transsexualism and polycystic ovary syndrome

    Tsuyoshi Baba, Toshiaki Endo, Keiko Ikeda, Tsuyoshi Saito

    Gender Identity: Disorders, Developmental Perspectives and Social Implications   253 - 270   2014年7月

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    記述言語:英語   掲載種別:論文集(書籍)内論文   出版者・発行元:Nova Science Publishers, Inc.  

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  • Continuous high-dose estrogen controls serum FSH and LH levels: new treatment strategy for extremely low ovarian reserve patients, two case reports. 国際誌

    Hiroyuki Honnma, Yoshimasa Asada, Tsuyoshi Baba, Toshiaki Endo

    Gynecological endocrinology : the official journal of the International Society of Gynecological Endocrinology   30 ( 5 )   341 - 4   2014年5月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    At present, there are no proven therapies to improve ovarian function in women with premature ovarian insufficiency (POI) or in those with extremely low ovarian reserve (LOR). We report successful IVF outcomes achieved with continuous high-dose estrogen supplementation in patients with LOR. Patients were 33- and 42-year-old nulligravidae with high-serum FSH (over 30 IU/L) and undetectable serum AMH (under 0.1 ng/mL) levels; however, neither patient fulfilled the diagnostic criteria for POI. After cycle cancellation and unsuccessful IVF treatment, both patients received conjugated estrogen (CE) supplementation (2.5-3.75 mg/day) from day 2 of their menstrual cycle to the day of HCG administration in their IVF treatment cycles. Following continuous high-dose estrogen supplementation, oocytes were successfully retrieved from both patients and fertilized. Both patients also achieved ongoing pregnancy through frozen-thawed embryo transfer cycles. In conclusion, high-dose estrogen supplementation down-regulated serum FSH and LH within their physiological ranges, which led to functional follicle growth and prevented early luteinization. Further studies will be needed to confirm the effect of this treatment on POI patients and to establish a new and individualized protocol for LOR patients.

    DOI: 10.3109/09513590.2013.871524

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  • Long-term treatment with dehydroepiandrosterone may lead to follicular atresia through interaction with anti-Mullerian hormone 査読 国際誌

    Keiko Ikeda, Tsuyoshi Baba, Miyuki Morishita, Hiroyuki Honnma, Toshiaki Endo, Tamotsu Kiya, Tsuyoshi Saito

    JOURNAL OF OVARIAN RESEARCH   7   46 - 46   2014年4月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    DOI: 10.1186/1757-2215-7-46

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  • Excessive androgen exposure as an etiological factor of polycystic ovary syndrome

    Tsuyoshi Baba, Toshiaki Endo, Sayaka Adachi, Keiko Ikeda, Ayumi Shimizu, Miyuki Morishita, Yoshika Kuno, Hiroyuki Honnma, Tamotsu Kiya, Tsuyoshi Saito

    Journal of Mammalian Ova Research   31 ( 1 )   23 - 30   2014年

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    記述言語:英語   掲載種別:研究論文(国際会議プロシーディングス)   出版者・発行元:Japanese Society of Mammalian Ova Research  

    DOI: 10.1274/jmor.31.23

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  • Difficulty in the management of pregnancy after vaginal radical trachelectomy.

    Sakura Takada, Shin-Ichi Ishioka, Toshiaki Endo, Tsuyoshi Baba, Miyuki Morishita, Yushi Akashi, Masahito Mizuuchi, Hidefumi Adachi, Miseon Kim, Tsuyoshi Saito

    International journal of clinical oncology   18 ( 6 )   1085 - 90   2013年12月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    BACKGROUND: We have performed 26 vaginal radical trachelectomies (RTs) for patients with early invasive uterine cervical cancer since 2003 and, to date, have experienced 8 deliveries. The procedure has a high risk for preterm labor and the subsequent occurrence of preterm premature rupture of membranes (pPROM). We report the present situation and the limits of follow-up of pregnancy after vaginal RT. METHODS: Our operative procedure is based on that of Dargent et al. We usually amputate the cervix approximately 10 mm below the isthmus. To remove the parametrium, we cut at the level of type II hysterectomy. Pregnancy courses after vaginal RT were studied in 8 patients with respect to symptoms, cervical length, and several infectious signs. RESULTS: We recommended that patients enter hospital early in their second trimester, and prophylactic daily vaginal disinfection with povidone-iodine and an ulinastatin vaginal suppository were administered. Careful checking for vaginal infectious signs, as well as cervical length and abdominal tension of patients was also performed. Four patients followed up with this modality were able to continue their pregnancies until late in the third trimester. However, this follow-up modality was not effective for patients who showed cervical incompetence due to slack cervical cerclage. They suffered from pPROM at 26 and 19 weeks of gestation. CONCLUSION: We need a new approach for the management of pregnant patients after vaginal RT with cervical incompetence due to slack cervical cerclage to prevent cervical infection.

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  • Assisted reproductive technique increases the risk of placental polyp 査読 国際誌

    Tsuyoshi Baba, Toshiaki Endo, Keiko Ikeda, Ayumi Shimizu, Miyuki Morishita, Yoshika Kuno, Hiroyuki Honnma, Tamotsu Kiya, Shin-Ichi Ishioka, Tsuyoshi Saito

    Gynecological Endocrinology   29 ( 6 )   611 - 614   2013年6月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)   出版者・発行元:6  

    DOI: 10.3109/09513590.2013.788636

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  • Failure of GnRH agonist-triggered oocyte maturation: its cause and management. 国際誌

    Yoshimasa Asada, Fumiaki Itoi, Hiroyuki Honnma, Shuji Takiguchi, Noritaka Fukunaga, Yoshiki Hashiba, Tsuyoshi Baba, Toshiaki Endo

    Journal of assisted reproduction and genetics   30 ( 4 )   581 - 5   2013年4月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    OBJECTIVE: In the present study we investigated the cause of GnRHa's failure to trigger oocyte maturation and present an effective rescue protocol for use when failure occurs. DESIGN: Case reports. SETTING: One in vitro fertilization (IVF) center. PATIENT(S): Eight cases of failure of GnRH agonist (GnRHa)-triggered oocyte maturation and one case of GnRHa successfully triggered oocyte maturation, despite a weak response in the LH-RH test. MAIN OUTCOME MEASURE(S): All cases were successfully rescued by re-triggering maturation using HCG, with seven of the eight patients achieving ongoing pregnancy and successful delivery. RESULT(S): In three patients the cause of the oocyte maturation failure was likely temporal or continuous severe down-regulation of the hypothalamus-pituitary-axis, the cause was unknown in the other five patients. CONCLUSION(S): In cases where GnRHa fails to trigger oocyte maturation, a rescue protocol entailing re-triggering with HCG can produce successful outcomes.

    DOI: 10.1007/s10815-013-9966-4

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  • Excessive androgen exposure in female-to-male transsexual persons of reproductive age induces hyperplasia of the ovarian cortex and stroma but not polycystic ovary morphology 査読 国際誌

    Keiko Ikeda, Tsuyoshi Baba, Hiroko Noguchi, Kunihiko Nagasawa, Toshiaki Endo, Tamotsu Kiya, Tsuyoshi Saito

    HUMAN REPRODUCTION   28 ( 2 )   453 - 461   2013年2月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    DOI: 10.1093/humrep/des385

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  • Serum anti-Mullerian hormone levels affect the rate of ongoing pregnancy after in vitro fertilization. 国際誌

    Hiroyuki Honnma, Tsuyoshi Baba, Masahiro Sasaki, Yoshiki Hashiba, Hisanori Oguri, Takanori Fukunaga, Toshiaki Endo, Yoshimasa Asada

    Reproductive sciences (Thousand Oaks, Calif.)   20 ( 1 )   51 - 9   2013年1月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    We used logistic regression analysis to investigate the relationship between serum anti-Mullerian hormone (AMH) levels and the rate of ongoing pregnancy. Retrospective data were collected from 1043 women who had undergone their first cycle of in vitro fertilization (IVF), including 540 cycles of fresh embryo transfer and 503 cycles of frozen-thawed embryo transfer. The patients were divided into 4 groups based on the cutoff values from a receiver-operating characteristic curve: 0.0 to 12.4, 12.5 to 25.5, 25.6 to 44.1, and >44.2 pmol/L. After adjustment for multiple confounders, the serum AMH group was found to be significantly related to the rate of ongoing pregnancy in total cycles (0.0-12.4 vs 12.5-25.5 pmol/L; P = .0088, odds ratio, 1.909: vs 25.6-44.1 pmol/L; P = .0281, odds ratio, 2.109: vs >44.2 pmol/L; P = .0008, odds ratio, 2.840). In conclusion, there appears to be a significant relationship between serum AMH levels and the ongoing pregnancy rate in first IVF treatment cycles after adjustment for multiple confounders.

    DOI: 10.1177/1933719112450329

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  • A myotonic dystrophy 1 patient complicated with placental adherence after miscarriage of one dichorionic diamniotic twin following her tenth in vitro fertilization and embryo transfer 査読 国際誌

    Toshiaki Endo, Tsuyoshi Baba, Asuka Sugio, Miyuki Morishita, Madoka Takahashi, Yushi Akashi, Shinichi Ishioka, Nobutada Tachi, Tomihiro Imai, Mitsuharu Tamakawa, Tsuyoshi Saito

    ARCHIVES OF GYNECOLOGY AND OBSTETRICS   286 ( 6 )   1605 - 1608   2012年12月

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  • Weight reduction and pioglitazone ameliorate polycystic ovary syndrome after removal of a Sertoli-stromal cell tumor 査読 国際誌

    Tsuyoshi Baba, Toshiaki Endo, Keiko Ikeda, Ayumi Shimizu, Miyuki Morishita, Yoshika Kuno, Hiroyuki Honnma, Tamotsu Kiya, Shin-Ichi Ishioka, Tsuyoshi Saito

    International Journal of Women's Health   4 ( 1 )   607 - 611   2012年11月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    DOI: 10.2147/IJWH.S36667

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  • 母児ともに救命し得た大動脈解離合併妊娠の3例

    嶋田 浩志, 岡村 直樹, 染谷 真行, 齋藤 雅恵, 竹田 倫子, 浅野 拓也, 明石 祐史, 馬場 剛, 石岡 伸一, 遠藤 俊明, 齋藤 豪

    北日本産科婦人科学会総会・学術講演会プログラム・抄録集   60回   90 - 90   2012年9月

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    記述言語:日本語   出版者・発行元:東北連合産科婦人科学会・北日本産科婦人科学会  

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  • 160kg高度肥満妊婦に対する帝王切開の経験

    中嶋 千紗, 馬場 剛, 森下 美幸, 金 美善, 足立 英文, 明石 祐史, 浅野 拓也, 嶋田 浩志, 杉尾 明香, 石岡 伸一, 遠藤 俊明, 齋藤 豪

    北日本産科婦人科学会総会・学術講演会プログラム・抄録集   60回   87 - 87   2012年9月

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    記述言語:日本語   出版者・発行元:東北連合産科婦人科学会・北日本産科婦人科学会  

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  • Trophectoderm morphology significantly affects the rates of ongoing pregnancy and miscarriage in frozen-thawed single-blastocyst transfer cycle in vitro fertilization. 国際誌

    Hiroyuki Honnma, Tsuyoshi Baba, Masahiro Sasaki, Yoshiki Hashiba, Hiroshi Ohno, Takanori Fukunaga, Toshiaki Endo, Tsuyoshi Saito, Yoshimasa Asada

    Fertility and sterility   98 ( 2 )   361 - 7   2012年8月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    OBJECTIVE: To determine which parameter of blastocyst morphology is the most important predictor of ongoing pregnancy or miscarriage. DESIGN: Retrospective analysis. SETTING: One in vitro fertilization (IVF) center. PATIENT(S): Women who underwent a total of 1,087 frozen-thawed single-blastocyst transfer cycles. INTERVENTION(S): First IVF treatment with blastocysts after frozen-thawed cycle. MAIN OUTCOME MEASURE(S): Ongoing pregnancy and miscarriage rates as related to blastocyst morphology (blastocyst expansion, inner cell mass, and trophectoderm), and interaction tests in unadjusted logistic regression models to assess clinical factors affecting outcomes. RESULT(S): After adjustment for trophectoderm, inner cell mass, and age as confounders, trophectoderm was determined to be statistically significantly related to the rate of ongoing pregnancy. Trophectoderm was also statistically significantly related to the miscarriage rate. By contrast, neither inner cell mass nor blastocyst expansion was statistically significantly related. CONCLUSION(S): In frozen-thawed embryo transfer cycles, trophectoderm morphology is statistically significantly related to the rates of ongoing pregnancy and miscarriage after adjusting for confounders. Trophectoderm morphology may be the most important parameter when selecting a single blastocyst for transfer.

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  • Simultaneous presentation of tubal and primary abdominal pregnancies following clomiphene citrate treatment. 国際誌

    Tsuyoshi Baba, Toshiaki Endo, Keiko Ikeda, Naoko Takenami, Ayumi Shimizu, Miyuki Morishita, Hiroyuki Honnma, Hideyuki Ikeda, Tsuyoshi Saito

    Archives of gynecology and obstetrics   286 ( 2 )   395 - 8   2012年8月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    Abdominal pregnancy is a rare condition that is potentially life-threatening for the mother. We present a case of simultaneous ectopic pregnancies (EPs) in the right fallopian tube and in the vesicouterine pouch. A 26-year-old woman had undergone prior ovulation induction with clomiphene citrate and human chorionic gonadotropin (hCG) at an outside hospital for unexplained infertility. The patient was referred to our hospital for a suspected ectopic pregnancy at 6 weeks gestation. Transvaginal ultrasonography detected a viable fetus at the anterior left side of the uterus; therefore, we suspected a left tubal pregnancy. However, laparoscopic surgery revealed that EPs were located in both the left vesicouterine pouch and in the right fallopian tube. Resection of the right salpinx and abdominal implant were performed. Histopathological examination confirmed the simultaneous presentation of a primary abdominal pregnancy and a right tubal pregnancy. After surgery, the patient's serum hCG level returned to normal. Concurrent EPs and abdominal pregnancy are very rare. However, it should be noted that reproductive technologies sometimes cause unusual clinical situations. A thorough abdominal inspection is needed.

    DOI: 10.1007/s00404-012-2300-z

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  • Different ovarian response by age in an anti-Müllerian hormone-matched group undergoing in vitro fertilization. 国際誌

    Hiroyuki Honnma, Tsuyoshi Baba, Masahiro Sasaki, Yoshiki Hashiba, Hisanori Oguri, Takanori Fukunaga, Toshiaki Endo, Yoshimasa Asada

    Journal of assisted reproduction and genetics   29 ( 2 )   117 - 25   2012年2月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    BACKGROUND: Recently, serum anti-Müllerian hormone (AMH) has been used as a good marker of ovarian response during in vitro fertilization (IVF). However, in the clinical setting, we felt that ovarian response was clearly different by age with the same AMH level. Then in this study we evaluated the relationship between serum AMH, age and parameters related to ovarian response and compared these parameters in regard to age within serum AMH-matched group. METHODS AND RESULTS: The relationship of these parameters were evaluated retrospectively in patients undergoing their first IVF cycle under a GnRH agonist flare up protocol (n = 456) between October 2008 and October 2010 in our clinic. To understand the relations between variables described above, principal component analysis (PCA) was performed. PCA revealed patients' age was at the different dimension from serum AMH and other variables. Therefore at first we segregated all patients into Low, Normal and High responder groups by their serum AMH using cut-off value of receiver operator characteristics curve analysis. Secondary, we divided each responder group into four subgroups according to patients' age. The high aged subgroups required a significantly higher dose of gonadotropin and a longer duration of stimulation; however, they had significantly lower peak E2 and a smaller number of total oocytes as well as M2 oocytes compared to the low aged subgroups. CONCLUSIONS: The influence of aging on the ovarian response was clearly seen in all groups; the ovarian response tended to decrease as patients' age increased with the same AMH level. Therefore serum AMH in combination with age is a better indicator than AMH alone.

    DOI: 10.1007/s10815-011-9675-9

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  • Continuous follicle-stimulating hormone exposure from pituitary adenoma causes periodic follicle recruitment and atresia, which mimics ovarian hyperstimulation syndrome. 国際誌

    Mika Kanaya, Tsuyoshi Baba, Yoshimitsu Kitajima, Keiko Ikeda, Ayumi Shimizu, Miyuki Morishita, Hiroyuki Honnma, Toshiaki Endo, Tsuyoshi Saito

    International journal of women's health   4   427 - 31   2012年

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    記述言語:英語  

    CONTEXT: Follicle-stimulating hormone (FSH)-secreting pituitary adenoma is usually a nonfunctioning tumor, but in rare cases it may develop into ovarian hyperstimulation. Several reports have revealed that serum FSH levels are normal to slightly high in patients with combined FSH-secreting pituitary adenoma with ovarian hyperstimulation. This finding is different from iatrogenic ovarian hyperstimulation syndrome (OHSS), which is associated with extremely high levels of FSH. OBJECTIVE: To describe the clinical course of two patients who developed OHSS from FSH-secreting pituitary adenoma. RESULTS: Endocrine studies of the two cases revealed that FSH levels were normal or slightly increased, but luteinizing hormone levels were low to undetectable. Their estradiol (E2) levels were intriguing: levels fluctuated drastically over 6 weeks in Case 1, but stayed flat in Case 2. Ultrasonographic examinations showed bilaterally enlarged multicystic ovaries, and magnetic resonance imaging indicated pituitary tumors. Transsephenoidal resection of the tumors ameliorated the symptoms and pathological diagnosis revealed FSH-secreting pituitary adenomas. CONCLUSION: As is not the case in iatrogenic OHSS, even a small to moderate amount of FSH stimulation, which is continuously secreted by a pituitary adenoma, can cause ovarian hyperstimulation. Although FSH-secreting pituitary adenoma can cause ovarian hyperstimulation, an extremely high amount of E2 biosynthesis from granulosa cells seldom occurs.

    DOI: 10.2147/IJWH.S33386

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  • A Remarkably Easy Knot-Tying Technique for Single-Incision Laparoscopic Surgery with the SILS Port for Gynecologic Diseases 査読 国際誌

    Toshiaki Endo, Kunihiko Nagasawa, Kota Umemura, Tsuyoshi Baba, Hirofumi Henmi, Tsuyoshi Saito

    JOURNAL OF MINIMALLY INVASIVE GYNECOLOGY   18 ( 4 )   500 - 502   2011年7月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    DOI: 10.1016/j.jmig.2011.03.014

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  • Distinctive features of female-to-male transsexualism and prevalence of gender identity disorder in Japan. 国際誌

    Tsuyoshi Baba, Toshiaki Endo, Keiko Ikeda, Ayumi Shimizu, Hiroyuki Honnma, Hiroshi Ikeda, Naoya Masumori, Tousei Ohmura, Tamotsu Kiya, Takashi Fujimoto, Motoiki Koizumi, Tsuyoshi Saito

    The journal of sexual medicine   8 ( 6 )   1686 - 93   2011年6月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    INTRODUCTION: The prevalence of transsexualism is thought to differ among socio-geographic backgrounds, and little is known about its prevalence in Japan. Polycystic ovary syndrome (PCOS), which is known to be associated with insulin resistance and metabolic syndrome, is often seen in female-to-male (FTM) transsexual patients. Consequently, detection of PCOS is an important part of health care for these individuals. AIM: The purpose of this study was to assess the prevalence of transsexuality in Japan, as well as the incidences of PCOS and insulin resistance among Japanese FTM transsexual patients. METHODS: One hundred four male-to-female (MTF) and 238 FTM Japanese transsexual patients were studied. Medical histories, including histories of menstrual cycling and hormone treatment, were taken. To exclude other diseases, such as congenital adrenal hyperplasia and hormone-secreting tumors, thorough medical assessments, including transvaginal or transrectal ultrasonography and measurement of serum hormone levels and insulin resistance indexes, were performed. MAIN OUTCOME MEASURES: The diagnosis of PCOS was based on the Rotterdam 2003 criteria. RESULTS: Based on demographic statistics, the prevalences of MTF and FTM transsexuality are about 3.97 and 8.20 per 100,000 people, respectively, making the MTF-to-FTM ratio about 1:2. Of the FTM transsexual patients studied, 128 had not taken hormones before their initial assessment (untreated group); the remaining 50 self-administered androgen. Among the untreated group, 32.0% were diagnosed with PCOS, 30.1% were insulin-resistant, and 31.1% showed hypoadiponectinemia. CONCLUSIONS: The sex ratio among Japanese transsexuals is different than among Caucasians. PCOS and insulin resistance are common findings in FTM transsexual patients at initial presentation.

    DOI: 10.1111/j.1743-6109.2011.02252.x

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  • Changes of uterine blood flow after vaginal radical trachelectomy (VRT) in patients with early-stage uterine invasive cervical cancer. 国際誌

    Kota Umemura, Shin-ichi Ishioka, Toshiaki Endo, Tsuyoshi Baba, Yoshiaki Ezaka, Kunihiko Nagasawa, Madoka Takahashi, Masahito Mizuuchi, Nanako Iwami, Hidefumi Adachi, Noriko Takeda, Mitsuharu Tamagawa, Tsuyoshi Saito

    International journal of medical sciences   7 ( 5 )   260 - 6   2010年8月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    BACKGROUND: Vaginal radical trachectomy (RT) ligates and cuts several arteries supplying the uterus. Changes of blood supply to the uterus in two patients who experienced pregnancy and delivery were studied by using 3-D CT scanning. Effects of changes of blood supply to the uterus on the pregnancy courses were also examined. METHODS: Vascular distribution in the uterus was studied in two patients who received vaginal RT after delivery. Effects of changes of vascular distribution after vaginal RT were studied with respect to pregnancy courses and cervical functions. RESULTS: New arterial vascularization from the ascending branches of uterine arteries or other arteries occurred, and these new vessels seemed to supply blood to the remaining cervix. Differences of fetal growth and histopathological changes in the placenta between the two patients could not be detected. CONCLUSION: Ligation and cutting of several supplying arteries by RT induces new arterial vascularization and it does not seem to affect fetal growth and placental function.

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  • Remarkable features of ovarian morphology and reproductive hormones in insulin-resistant Zucker fatty (fa/fa) rats. 国際誌

    Hiroyuki Honnma, Toshiaki Endo, Tamotsu Kiya, Ayumi Shimizu, Kunihiko Nagasawa, Tsuyoshi Baba, Takashi Fujimoto, Hirofumi Henmi, Yoshimitsu Kitajima, Kengo Manase, Shinichi Ishioka, Eiki Ito, Tsuyoshi Saito

    Reproductive biology and endocrinology : RB&E   8   73 - 73   2010年6月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    BACKGROUND: Zucker fatty (fa/fa) rats are a well-understood model of obesity and hyperinsulinemia. It is now thought that obesity/hyperinsulinemia is an important cause of endocrinological abnormality, but to date there have been no reports on the changes in ovarian morphology or the ovarian androgen profile in rat models of obesity and insulin resistance. METHODS: In this study we investigated the effects of obesity and hyperinsulinemia on ovarian morphology and the hormone profile in insulin-resistant Zucker fatty rats (5, 8, 12 and 16 weeks of age, n = 6-7). RESULTS: Ovaries from 5-week-old fatty rats had significantly greater total and atretic follicle numbers, and higher atretic-to-total follicle ratios than those from lean rats. Ovaries from 12- and 16-week-old fatty rats showed interstitial cell hyperplasia and numerous cysts with features of advanced follicular atresia. In addition, serum testosterone and androstenedione levels significantly declined in fatty rats from age 8 to 16 weeks, so that fatty rats showed significantly lower levels of serum testosterone (12 and 16 weeks) and androstenedione (all weeks) than lean rats. This may reflect a reduction of androgen synthesis during follicular atresia. Serum adiponectin levels were high in immature fatty rats, and although the levels declined significantly as they matured, it remained significantly higher in fatty rats than in lean rats. On the other hand, levels of ovarian adiponectin and its receptors were significantly lower in mature fatty rats than in lean mature rats or immature fatty rats. CONCLUSIONS: Our findings indicate that ovarian morphology and hormone profiles are significantly altered by the continuous insulin resistance in Zucker fatty rats. Simultaneously, abrupt reductions in serum and ovarian adiponectin also likely contribute to the infertility seen in fatty rats.

    DOI: 10.1186/1477-7827-8-73

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  • Spontaneous ovarian hyperstimulation syndrome and pituitary adenoma: incidental pregnancy triggers a catastrophic event. 国際誌

    Tsuyoshi Baba, Toshiaki Endo, Yoshimitsu Kitajima, Hirofumi Kamiya, Osamu Moriwaka, Tsuyoshi Saito

    Fertility and sterility   92 ( 1 )   390.e1-3   2009年7月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    OBJECTIVE: To report a rare case of spontaneous ovarian hyperstimulation syndrome (OHSS) associated with spontaneous pregnancy and a FSH-secreting pituitary adenoma. DESIGN: Case report. SETTING: University hospital. PATIENT(S): A 32-year-old woman with spontaneous OHSS. INTERVENTION(S): Transsphenoidal resection of the tumor. MAIN OUTCOME MEASURE(S): Regression of the symptoms of OHSS and hyperestrogenemia. RESULT(S): At presentation, the patient's ovaries were markedly enlarged and massive ascites was seen. Her serum E(2) level was markedly elevated, but her LH level was low, and FSH was within the normal range. In addition, her TSH level was normal, and hCG was appropriate for the date of pregnancy. Subsequently, the patient developed massive thrombophlebitis in her right internal jugular and subclavian veins. Termination of the pregnancy ameliorated the accumulation of ascites, but ovarian enlargement and hyperestrogenemia persisted. No mutations of the FSH receptor, LH receptor, or aromatase genes were detected, but magnetic resonance imaging (MRI) of the head revealed a pituitary adenoma. After transsphenoidal resection of the tumor, the patient got better. CONCLUSION(S): A gonadotropin-secreting adenoma caused ovarian hyperstimulation (ovarian enlargement and hyperestrogenemia). In addition, spontaneous pregnancy and intrinsic hCG increased vascular permeability, which complicated the patient's disease.

    DOI: 10.1016/j.fertnstert.2009.02.071

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  • The contributions of resistin and adiponectin gene single nucleotide polymorphisms to the genetic risk for polycystic ovary syndrome in a Japanese population 査読 国際誌

    Tsuyoshi Baba, Toshiaki Endo, Fumihiro Sata, Kunihiko Nagasawa, Hiroyuki Honnma, Yoshimitsu Kitajima, Takuhiro Hayashi, Kengo Manase, Mika Kanaya, Osamu Moriwaka, Hirofumi Kamiya, Hideto Yamada, Hisanori Minakami, Reiko Kishi, Tsuyoshi Saito

    GYNECOLOGICAL ENDOCRINOLOGY   25 ( 8 )   498 - 503   2009年

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    DOI: 10.1080/09513590902972042

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  • Advanced epithelial ovarian carcinoma during pregnancy.

    Shin-ichi Ishioka, Takuhiro Hayashi, Toshiaki Endo, Tsuyoshi Baba, Hiroyuki Honma, Tsuyoshi Saito

    International journal of clinical oncology   12 ( 5 )   375 - 8   2007年10月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    We report a rare case of advanced ovarian mucinous adenocarcinoma in a pregnant woman. A 28-year-old pregnant Japanese woman was diagnosed with an ovarian tumor 8 cm in diameter at a local hospital. She was sent to a private hospital at 25 weeks of gestation because of the growing ovarian tumor. Advanced ovarian carcinoma with widespread intraabdominal dissemination was detected by laparotomy at the hospital and she was referred to our hospital for further management. At 27 weeks of gestation, she underwent cesarean section, followed by abdominal total hysterectomy, and bilateral salpingo-oophorectomy. A girl weighing 879 g was delivered, with Apgar scores of 4 and 6 at 1 and 5 min, respectively. The pathological diagnosis of the tumor was mucinous cystadenocarcinoma grade 2. Although chemotherapy was not effective for her and she died of the disease 4 months after the surgery, her baby grew well and weighed 3750 g 3 months after delivery. For the treatment of such patients, we believe we should choose operative therapy as early as possible after the maturation of the fetus, although there are several reports of successful treatment with the administration of chemotherapy during pregnancy. To determine a better approach for such patients, multidisciplinary staff meetings, including gynecological oncologists, obstetricians, neonatologists, psychologists, and the patient are important.

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  • Polycystic ovary syndrome is associated with genetic polymorphism in the insulin signaling gene IRS-1 but not ENPP1 in a Japanese population. 国際誌

    Tsuyoshi Baba, Toshiaki Endo, Fumihiro Sata, Hiroyuki Honnma, Yoshimitsu Kitajima, Takuhiro Hayashi, Kengo Manase, Mika Kanaya, Hideto Yamada, Hisanori Minakami, Reiko Kishi, Tsuyoshi Saito

    Life sciences   81 ( 10 )   850 - 4   2007年8月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    Recent studies indicate that insulin resistance resulting from altered post-receptor signaling is associated with polycystic ovary syndrome (PCOS). We hypothesized that insulin receptor substrate-1 (IRS-1) Gly972Arg polymorphism and/or ectonucleotide pyrophosphatase/phosphodiesterase 1 (ENPP1) Lys121Gln polymorphism predisposes women to PCOS and that these polymorphisms also affect anthropometric variables, glucose metabolism and androgen synthesis. To test those ideas, we studied the genotypes, indexes of insulin resistance, and hormone profiles in 123 Japanese women with PCOS and 380 healthy Japanese controls. We found that there were significantly more IRS-1 972Arg carriers among the PCOS patients than among the healthy controls (10.6% vs. 4.8%, p=0.029), which is consistent with our finding that women carrying the IRS-1 972Arg allele had a significantly increased risk of developing PCOS (odds ratio: 3.31, 95% confidence interval: 1.49-7.35). By contrast, the ENPP1 Lys121Arg polymorphism was distributed equally among PCOS patients and controls. In addition, neither of these polymorphisms studied affected the anthropometric variables, metabolic parameters or androgen levels of women with PCOS. We conclude that the IRS-1 Gly972Arg polymorphism is associated with PCOS in the Japanese population.

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  • Association between polycystic ovary syndrome and female-to-male transsexuality. 国際誌

    Tsuyoshi Baba, Toshiaki Endo, Hiroyuki Honnma, Yoshimitsu Kitajima, Takuhiro Hayashi, Hiroshi Ikeda, Naoya Masumori, Hirofumi Kamiya, Osamu Moriwaka, Tsuyoshi Saito

    Human reproduction (Oxford, England)   22 ( 4 )   1011 - 6   2007年4月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    BACKGROUND: The aim of this study is to understand the relationship between polycystic ovary syndrome (PCOS), altered hormonal characteristics and insulin resistance in female-to-male (FTM) transsexual patients. METHODS: We studied 69 Japanese FTM cases, aged 17-47 years, who were seen in the Gender Identity Disorder Clinic of Sapporo Medical University Hospital between December 2003 and May 2006. The subjects had never received hormonal treatment or sex re-assignment surgery. Prior to treatment, they received physical examinations entailing measurement of anthropometric, metabolic and endocrine parameters, after which we compared the values obtained according to the presence or absence of PCOS and/or obesity. Insulin resistance was determined using the homeostasis model assessment of insulin resistance (HOMA-IR). RESULTS: Of the 69 participating FTM cases, 40 (58.0%) were found to have PCOS. Of the 49 for whom HOMA-IR was calculated, 15 (30.6%) also showed insulin resistance, whereas of the 59 for whom adiponectin was measured, 18 (30.5%) showed hypoadiponectinaemia. Of 69 for whom androgens were measured, 29 (39.1%) showed hyperandrogenaemia. Insulin resistance was associated with obesity but not with PCOS. In contrast, hyperandrogenaemia was associated with both PCOS and obesity. CONCLUSION: FTM transsexual patients have a high prevalence of PCOS and hyperandrogenaemia.

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  • Significance of matrix metalloproteinases in the pathophysiology of the ovary and uterus.

    Toshiaki Endo, Tamotsu Kiya, Taeko Goto, Hirofumi Henmi, Kengo Manase, Hiroyuki Honnma, Tsuyoshi Baba, Shinichi Ishioka, Takuhiro Hayashi, Manabu Chida, Kazuyo Arima, Kiyohiro Yamazaki, Mika Kanaya, Atsushi Azumaguchi, Osamu Moriwaka, Hirofumi Kamiya, Tsuyoshi Saito

    Reproductive medicine and biology   5 ( 4 )   235 - 243   2006年12月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    Matrix metalloproteinases (MMP) are capable of degrading a variety of extracellular matrix (ECM) proteins and are also involved in the processing of a number of bioactive molecules. Our findings indicate that the functions of MMP in the ovary and uterus are organ-specific and time-dependently vary during the reproductive cycle. Prolactin induces structural luteolysis indicated by loss of luteal weight, protein and DNA within 36 h after pretreatment with ergot alkaloid. MMP activation appears crucial for the selective depletion of protein during luteal involution, which entails loss of ECM accompanied by apoptosis. During GnRHagonist-induced luteolysis, this response was also associated with marked increases in MMP-2, which degraded collagen type IV, and MT1-MMP, which in addition to activating MMP-2 also degrades collagen type I, III and V. We also found that the level of MT1-MMP and MMP-2 expression in the human CL is greater during the late luteal phase than during either the early mid luteal phases or during gestation, respectively. That dehydroepiandrosterone (DHEA) treatment caused the formation of cysts from antral follicles in the ovaries of immature rats while depressing MMP-2 collagenolytic activity and enhancing lysyl oxidase expression highlights the importance of collagen degradation in the process of ovulation and suggests that changes in the activities of these enzymes play a key role in ovarian cystogenesis in polycystic ovary syndrome patients. Furthermore, immunohistochemical analyses showed that MT1-MMP and FasL co-localize with TdT-mediated dUTP-biotin nick end-labeling (TUNEL)-positive apoptotic granulosa cells in rats treated with DHEA, that the Fas/FasL/Caspase-8 (death receptor-dependent) pathway is pivotal for follicular atresia and that increased levels of MT1-MMP likely play an important role in tissue remodeling during follicular atresia. After parturition, the uterus undergoes involution, a conspicuous feature characterized by a rapid reduction in the collagen content mediated by degradation of extracellular collagen bundles. Our findings strongly suggest that MT1-MMP, MMP-2 and MMP-9 are each time-dependently regulated and play important roles in tissue remodeling during postpartum uterine involution. (Reprod Med Biol 2006; 5: 235-243).

    DOI: 10.1111/j.1447-0578.2006.00147.x

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  • Altered expression of Fas/Fas ligand/caspase 8 and membrane type 1-matrix metalloproteinase in atretic follicles within dehydroepiandrosterone-induced polycystic ovaries in rats. 国際誌

    Hiroyuki Honnma, Toshiaki Endo, Hirofumi Henmi, Kunihiko Nagasawa, Tsuyoshi Baba, Kiyohiro Yamazaki, Yoshimitsu Kitajima, Takuhiro Hayashi, Kengo Manase, Tsuyoshi Saito

    Apoptosis : an international journal on programmed cell death   11 ( 9 )   1525 - 33   2006年9月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    One of the characteristics of polycystic ovary syndrome (PCOS) is the presence of cystic follicles in various stages of growth and atresia, the latter of which is known to be the result of apoptosis and tissue remodeling. To further investigate the process of follicular atresia, we compared ovarian expression and localization of Fas, Fas ligand (FasL), casapse-8 and membrane-type1 matrix metalloproteinase (MT1-MMP) in rats treated with dehydroepiandrosterone (DHEA) as a model of PCOS, and in control rats. We found that the numbers of TdT-mediated dUTP-biotin nick end-labeling (TUNEL)-positive follicles were significantly higher in ovaries from PCOS rats than in those from control rats (P < 0.05), as were ovarian levels of FasL mRNA and protein, processed caspase-8 protein and MT1-MMP mRNA. Correspondingly, we also observed an increase in the level of MTI-MMP catalytic activity and a decrease in the level of pro-caspase-8 protein. In addition, immunohistochemical analyses showed that MT1-MMP and FasL co-localize with TUNEL-positive apoptotic granulosa cells within atretic follicles of PCOS ovaries. Our results suggest that under the PCOS-like conditions induced by DHEA, the Fas/FasL/Caspase-8 (death receptor dependent) pathway is pivotal for follicular atresia, and that increased levels of MT1-MMP likely play an important role in tissue remodeling during structural luteolysis.

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  • Hyperstimulation and a gonadotropin-releasing hormone agonist modulate ovarian vascular permeability by altering expression of the tight junction protein claudin-5. 国際誌

    Yoshimitsu Kitajima, Toshiaki Endo, Kunihiko Nagasawa, Kengo Manase, Hiroyuki Honnma, Tsuyoshi Baba, Takuhiro Hayashi, Hideki Chiba, Norimasa Sawada, Tsuyoshi Saito

    Endocrinology   147 ( 2 )   694 - 9   2006年2月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    We investigated the mechanism by which a GnRH agonist (GnRHa) affects ovarian vascularity, vascular permeability, and expression of the tight junction protein claudin-5 in a rat model of ovarian hyperstimulation syndrome (OHSS). Hyperstimulated rats received excessive doses of pregnant mare serum gonadotropin (PMSG; 50 IU/d) for 4 consecutive days, from d 25 to 28 of life, followed by 25 IU human chorionic gonadotropin (hCG) on d 29. Control rats received 10 IU PMSG on d 27 of life, followed by 10 IU hCG on d 29. GnRHa (leuprolide 100 microg/kg.d) was administered to some hyperstimulated rats either on d 29 and 30 (short-term GnRHa treatment) or from d 25 to 30 (long-term GnRHa treatment). Ovarian vascular density (vessels per 10 mm(2)) and vessel endothelial area (percent) were assessed by immunohistochemical analysis of the distribution of von Willebrand factor, whereas vascular permeability was evaluated based on leakage of Evans blue. High doses of PMSG and hCG significantly increased ovarian weight, vascular permeability, vascular density, and the vessel endothelial area and significantly reduced expression of claudin-5 protein and mRNA. All of these effects were significantly and dose-dependently inhibited by administration of GnRHa. This suggests that reduced expression of claudin-5 plays a crucial role in the increased ovarian vascular permeability seen in OHSS and that its expression can be modulated by GnRHa treatment. Indeed, preventing redistribution of tight junction proteins in endothelial cells and the resultant loss of endothelial barrier architecture might be the key to protecting patients against massive extravascular fluid accumulation in cases of OHSS.

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  • 17th Symposium on Gynecology and Colposcopy July 15-16, 1998, Osaka, Japan. Characterization of subclonal cell lines showing high motility derived from an undifferentiated human endometrial cancer cell line

    Motoiki Koizumi, Eiki Ito, Satoko Yamashita, Tsuyoshi Baba, Ikuhito Yamanaka, Takahiro Suzuki, Ryuichi Kudo

    Gynecologic and Obstetric Investigation   48 ( 3 )   206 - 210   1999年

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    記述言語:英語   掲載種別:研究論文(国際会議プロシーディングス)  

    DOI: 10.1159/000010157

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  • Cloning and characterization of a cDNA fragment coding β-casein-like protein preferentially expressed in cervical adenocarcinoma cell line CAC-1

    Takahiro Suzuki, Motoiki Koizumi, Tsuyoshi Baba, Ryuichi Kudo

    Cancer Letters   124 ( 2 )   165 - 171   1998年2月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)   出版者・発行元:Elsevier Ireland Ltd  

    DOI: 10.1016/S0304-3835(97)00471-0

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MISC

  • Editor’s Focus: Maternal Alcohol Use and Fetal Growth in Japan 招待 国際誌

    Kazutoshi Cho, Sumitaka Kobayashi, Atsuko Araki, Chihiro Miyashita, Sachiko Itoh, Yasuaki Saijo, Yoshiya Ito, Kazuo Sengoku, Tsuyoshi Baba, Hisanori Minakami, Yuichi Nakamura, Reiko Kishi, The Japan Environment and Children’s Study Group

    Pediatric Research   92 ( 1 )   1 - 1   2022年7月

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    記述言語:英語   掲載種別:記事・総説・解説・論説等(学術雑誌)   出版者・発行元:Springer Science and Business Media LLC  

    掲載論文(責任著者)が、Pediatric Research volume 92 No. 1 July 2022のEditor’s Focusに選出され紹介された。掲載論文:Kazutoshi Cho, Sumitaka Kobayashi, et al. Prenatal alcohol exposure and adverse fetal growth restriction: findings from the Japan Environment and Children's Study. Pediatric Research. 2022; 92: 291-298. https://doi.org/10.1038/s41390-021-01595-3.

    その他リンク:: https://www.nature.com/articles/s41390-022-02221-6

    DOI: 10.1038/s41390-022-02221-6

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  • 当院における思春期前症例の卵巣組織ガラス化保存と周術期の問題点について

    馬場 剛, 玉手 雅人, 春日 芙貴子, 長尾 沙智子, 藤部 佑哉, 木井 菜摘, 君塚 基修, 齋藤 豪

    日本がん・生殖医療学会誌   5 ( 1 )   139 - 139   2022年1月

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    記述言語:日本語   出版者・発行元:(一社)日本がん・生殖医療学会  

    医中誌

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  • 妊娠に至ったGonadotropin resistant ovaryの1症例

    久野 芳佳, 馬場 剛, 春日 芙貴子, 古来 愛香, 玉手 雅人, 小川 万梨絵, 池田 桂子, 森下 美幸, 遠藤 俊明, 齋藤 豪

    日本生殖医学会雑誌   66 ( 4 )   403 - 403   2021年10月

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    記述言語:日本語   出版者・発行元:(一社)日本生殖医学会  

    医中誌

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  • 当科における卵巣組織凍結の報告と北海道内の同技術の認識について

    古来 愛香, 玉手 雅人, 春日 芙貴子, 長尾 沙智子, 小川 万梨絵, 池田 桂子, 久野 芳佳, 森下 美幸, 馬場 剛, 齋藤 豪

    日本生殖医学会雑誌   66 ( 4 )   316 - 316   2021年10月

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    記述言語:日本語   出版者・発行元:(一社)日本生殖医学会  

    医中誌

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  • 月経不順を契機に診断されたトルコ鞍黄色肉芽腫の1例

    小川 万梨絵, 馬場 剛, 春日 芙貴子, 古来 愛香, 玉手 雅人, 池田 桂子, 森下 美幸, 久野 芳佳, 遠藤 俊明, 齋藤 豪

    日本生殖医学会雑誌   66 ( 4 )   346 - 346   2021年10月

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    記述言語:日本語   出版者・発行元:(一社)日本生殖医学会  

    医中誌

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  • 腟式広汎子宮頸部摘出術後妊娠症例におけるFFPE胎盤検体を用いたメタゲノム解析の試み

    真里谷 奨, 石岡 伸一, 長井 陽子, 藤部 佑哉, 新開 翔太, 染谷 真行, 馬場 剛, 齋藤 豪

    日本周産期・新生児医学会雑誌   57 ( Suppl. )   P237 - P237   2021年6月

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    記述言語:日本語   出版者・発行元:(一社)日本周産期・新生児医学会  

    医中誌

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  • 子宮粘膜下に発達した嚢胞性腺筋症に対し腹腔鏡下核出術を施行した1例

    小川 栞, 真里谷 奨, 新開 翔太, 久野 芳佳, 森下 美幸, 馬場 剛, 齋藤 豪

    産婦人科手術   ( 32 )   142 - 142   2021年6月

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    記述言語:日本語   出版者・発行元:(株)メジカルビュー社  

    医中誌

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  • 当科におけるModified B-Lynch縫合施行21症例の検討

    安宅 真名美, 石岡 伸一, 新開 翔太, 真里谷 奨, 染谷 真行, 小川 万梨絵, 森下 美幸, 馬場 剛, 齋藤 豪

    産婦人科手術   ( 32 )   146 - 146   2021年6月

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    記述言語:日本語   出版者・発行元:(株)メジカルビュー社  

    医中誌

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  • 異常浸潤性胎盤におけるPSGファミリーの新規バイオマーカーとしての可能性

    柏木 葉月, 真里谷 奨, 新開 翔太, 染谷 真行, 馬場 剛, 石岡 伸一, 齋藤 豪

    日本周産期・新生児医学会雑誌   57 ( Suppl. )   P202 - P202   2021年6月

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    記述言語:日本語   出版者・発行元:(一社)日本周産期・新生児医学会  

    医中誌

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  • Tocolysisの有用性よりみた出生体重1,000g未満母体症例に関する検討

    山下 真祐子, 石岡 伸一, 真里谷 奨, 新開 翔太, 染谷 真行, 森下 美幸, 馬場 剛, 齋藤 豪

    周産期医学   51 ( 4 )   675 - 680   2021年4月

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    記述言語:日本語   出版者・発行元:(株)東京医学社  

    医中誌

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  • 高次施設における帝王切開率抑制の試み

    染谷 真行, 新開 翔太, 真里谷 奨, 小川 万梨絵, 森下 美幸, 馬場 剛, 石岡 伸一, 齋藤 豪

    日本産科婦人科学会雑誌   73 ( 臨増 )   S - 367   2021年3月

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    記述言語:日本語   出版者・発行元:(公社)日本産科婦人科学会  

    医中誌

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  • PSGファミリーの異常浸潤性胎盤診断バイオマーカーとしての可能性

    柏木 葉月, 真里谷 奨, 新開 翔太, 染谷 真行, 小川 万梨絵, 森下 美幸, 馬場 剛, 石岡 伸一, 齋藤 豪

    日本産科婦人科学会雑誌   73 ( 臨増 )   S - 611   2021年3月

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    記述言語:日本語   出版者・発行元:(公社)日本産科婦人科学会  

    医中誌

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  • 開腹子宮頸部縫縮術(TAC)後妊娠初期流産症例に対するmethotrexate(MTX)療法の一例

    石堂茉泉, 石岡伸一, 藤部佑哉, 鈴木美紀, 嶋田浩志, 真里谷奨, 馬場剛, 齋藤豪

    日本周産期・新生児医学会雑誌(Web)   56 ( 1 )   2020年

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  • 妊娠中に原因不明の低カリウム血症による横紋筋融解症を発症した1例

    長尾 沙智子, 馬場 剛, 梅本 美菜, 新開 翔太, 鈴木 将裕, 真里谷 奨, 染谷 真行, 森下 美幸, 石岡 伸一, 齋藤 豪

    日本女性栄養・代謝学会学術集会プログラム・抄録集   43回   79 - 79   2019年9月

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    記述言語:日本語   出版者・発行元:日本女性栄養・代謝学会  

    医中誌

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  • 帝王切開後産科危機的出血に対して母体救命目的に子宮摘出を要した3症例の検討

    佐藤 由梨, 長尾 沙智子, 新開 翔太, 真里谷 奨, 森下 美幸, 馬場 剛, 石岡 伸一, 齋藤 豪

    北日本産科婦人科学会総会・学術講演会プログラム・抄録集   67回   75 - 75   2019年9月

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    記述言語:日本語   出版者・発行元:東北連合産科婦人科学会・北日本産科婦人科学会  

    医中誌

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  • 発症後早期の抗生剤治療が救命につながった激症分娩型A群連鎖球菌感染症

    石堂 茉泉, 嶋田 浩志, 倉 ありさ, 藤部 佑哉, 鈴木 美紀, 長尾 沙智子, 新開 翔太, 真里谷 奨, 染谷 真行, 森下 美幸, 馬場 剛, 石岡 伸一, 横田 伸一, 齋藤 豪

    北日本産科婦人科学会総会・学術講演会プログラム・抄録集   67回   61 - 61   2019年9月

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    記述言語:日本語   出版者・発行元:東北連合産科婦人科学会・北日本産科婦人科学会  

    医中誌

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  • 当院における超緊急帝王切開(NICE分類カテゴリー1)の母児転帰に関する検討

    新開 翔太, 真里谷 奨, 長尾 沙智子, 染谷 真行, 森下 美幸, 馬場 剛, 石岡 伸一, 齋藤 豪

    北日本産科婦人科学会総会・学術講演会プログラム・抄録集   67回   75 - 75   2019年9月

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    記述言語:日本語   出版者・発行元:東北連合産科婦人科学会・北日本産科婦人科学会  

    医中誌

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  • 妊娠前施行開腹子宮頸管縫縮術(TAC)の現状と産科予後を改善するための工夫

    石岡 伸一, 真里谷 奨, 水柿 祐子, 川俣 あかり, 水内 将人, 森下 美幸, 馬場 剛, 齋藤 豪

    産婦人科手術   ( 30 )   128 - 128   2019年8月

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    記述言語:日本語   出版者・発行元:(株)メジカルビュー社  

    医中誌

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  • NT肥厚を契機に診断された10番染色体長腕末端欠失の一例

    川俣 あかり, 水内 将人, 斉藤 公人, 水柿 祐子, 真里谷 奨, 森下 美幸, 馬場 剛, 石岡 伸一, 齋藤 豪

    日本遺伝カウンセリング学会誌   40 ( 2 )   114 - 114   2019年7月

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    記述言語:日本語   出版者・発行元:(一社)日本遺伝カウンセリング学会  

    医中誌

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  • NGSDプロジェクトにおける領域横断的な遺伝カウンセリング研修の経験

    真里谷 奨, 宮崎 幸子, 寺田 倫子, 水上 都, 石川 亜貴, 馬場 剛, 石岡 伸一, 齋藤 豪, 櫻井 晃洋

    日本遺伝カウンセリング学会誌   40 ( 2 )   177 - 177   2019年7月

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    記述言語:日本語   出版者・発行元:(一社)日本遺伝カウンセリング学会  

    医中誌

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  • 進行子宮頸癌合併妊娠の検討

    寺本 瑞絵, 寺田 倫子, 藤部 佑哉, 真里谷 奨, 水内 将人, 馬場 剛, 石岡 伸一, 齊藤 豪

    日本周産期・新生児医学会雑誌   55 ( 2 )   480 - 480   2019年6月

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    記述言語:日本語   出版者・発行元:(一社)日本周産期・新生児医学会  

    医中誌

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  • 当院における18トリソミー症例の検討

    石堂 茉泉, 石岡 伸一, 真里谷 奨, 黒田 敬史, 水内 将人, 五十嵐 リサ, 馬場 剛, 小林 正樹, 齋藤 剛

    日本周産期・新生児医学会雑誌   55 ( 2 )   443 - 443   2019年6月

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    記述言語:日本語   出版者・発行元:(一社)日本周産期・新生児医学会  

    医中誌

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  • 妊娠子宮頸部静脈瘤破裂に対し交差二重マクドナルド頸管縫縮術を施行し止血し得た一例

    真里谷 奨, 藤部 佑哉, 水内 将人, 馬場 剛, 石岡 伸一, 齋藤 豪

    日本周産期・新生児医学会雑誌   55 ( 2 )   652 - 652   2019年6月

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    記述言語:日本語   出版者・発行元:(一社)日本周産期・新生児医学会  

    医中誌

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  • 異なる転機をたどったchorionic bumpの2例

    藤部 佑哉, 水内 将人, 嶋田 浩志, 真里谷 奨, 野呂 薫, 山中 郁仁, 寺本 瑞絵, 馬場 剛, 石岡 伸一, 齋藤 豪

    超音波医学   46 ( Suppl. )   S726 - S726   2019年4月

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    記述言語:日本語   出版者・発行元:(公社)日本超音波医学会  

    医中誌

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  • 広汎子宮頸部摘出術(RT)後の双胎妊娠の一例

    水柿 祐子, 石岡 伸一, 藤部 佑哉, 真里谷 奨, 川俣 あかり, 水内 将人, 森下 美幸, 馬場 剛, 齋藤 豪

    日本産科婦人科学会雑誌   71 ( 臨増 )   S - 391   2019年2月

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    記述言語:日本語   出版者・発行元:(公社)日本産科婦人科学会  

    医中誌

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  • 子宮頸部静脈瘤からの出血に対し子宮頸管縫縮術が有効であった一例

    川俣 あかり, 斉藤 公仁, 水柿 祐子, 藤部 佑哉, 真里谷 奨, 水内 将人, 森下 美幸, 馬場 剛, 石岡 伸一, 齋藤 豪

    日本産科婦人科学会雑誌   71 ( 臨増 )   S - 656   2019年2月

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    記述言語:日本語   出版者・発行元:(公社)日本産科婦人科学会  

    医中誌

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  • 癒着胎盤に対する両側総腸骨動脈バルーン閉塞術(CIABO)下の帝王切開中に総腸骨動脈解離を発症した一例

    斉藤 公仁, 真里谷 奨, 水柿 祐子, 藤部 佑哉, 川俣 あかり, 水内 将人, 森下 美幸, 馬場 剛, 石岡 伸一, 齋藤 豪

    日本産科婦人科学会雑誌   71 ( 臨増 )   S - 660   2019年2月

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    記述言語:日本語   出版者・発行元:(公社)日本産科婦人科学会  

    医中誌

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  • 当科における妊娠中の広汎子宮頸部摘出術施行症例の妊娠経過の検討

    石岡 伸一, 水柿 祐子, 藤部 佑哉, 真里谷 奨, 川俣 あかり, 水内 将人, 森下 美幸, 馬場 剛, 斎藤 豪

    日本癌治療学会学術集会抄録集   56回   P28 - 1   2018年10月

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    記述言語:英語   出版者・発行元:(一社)日本癌治療学会  

    医中誌

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  • 当周産期センターにおける子宮内胎児死亡症例を含む無痛分娩の実際

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    北日本産科婦人科学会総会・学術講演会プログラム・抄録集   66回   0076 - 0076   2018年9月

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    北日本産科婦人科学会総会・学術講演会プログラム・抄録集   66回   0094 - 0094   2018年9月

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    記述言語:日本語   出版者・発行元:東北連合産科婦人科学会・北日本産科婦人科学会  

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    日本産科婦人科内視鏡学会雑誌   34 ( Suppl.I )   297 - 297   2018年8月

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    記述言語:日本語   出版者・発行元:(一社)日本産科婦人科内視鏡学会  

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    日本周産期・新生児医学会雑誌   54 ( 2 )   597 - 597   2018年6月

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    日本産婦人科・新生児血液学会誌   28 ( 1 )   34 - 35   2018年5月

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  • 胎盤部トロホブラスト腫瘍(PSTT)を疑い診断に苦慮した一例

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    日本産科婦人科学会雑誌   70 ( 2 )   866 - 866   2018年2月

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    記述言語:日本語   出版者・発行元:(公社)日本産科婦人科学会  

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  • 癒着胎盤が疑われた症例におけるBalloon Occlusionの有用性についての検討

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    日本産科婦人科学会雑誌   70 ( 2 )   714 - 714   2018年2月

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    日本産科婦人科内視鏡学会雑誌   33 ( Suppl.I )   76 - 76   2017年8月

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    記述言語:日本語   出版者・発行元:(一社)日本産科婦人科内視鏡学会  

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  • 異なる転帰をたどった周郭胎盤の2例

    嶋田 浩志, 真里谷 奨, 高田 さくら, 水内 将人, 馬場 剛, 石岡 伸一, 齋藤 豪

    日本周産期・新生児医学会雑誌   53 ( 2 )   693 - 693   2017年6月

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  • 超音波検査により内膜症性嚢胞と誤認していたOHVIRA症候群に伴う腟留血腫の1例

    嶋田 浩志, 鹿内 智史, 真里谷 奨, 水内 将人, 馬場 剛, 石岡 伸一, 齋藤 豪

    超音波医学   44 ( Suppl. )   S680 - S680   2017年4月

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    医中誌

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  • 腹部手術既往が腹腔鏡手術へ及ぼす影響

    長尾 沙智子, 玉手 雅人, 金 美善, 杉尾 明香, 松浦 基樹, 明石 祐史, 馬場 剛, 田中 綾一, 齋藤 豪

    産科と婦人科   83 ( 12 )   1475 - 1479   2016年12月

  • 腹腔鏡下卵巣子宮内膜症性嚢胞核出術の工夫 本当に妊孕能温存に寄与しているのか

    杉尾 明香, 明石 祐史, 玉手 雅人, 森下 美幸, 馬場 剛, 遠藤 俊明, 齋藤 豪

    北海道産科婦人科学会会誌   60 ( 1 )   67 - 67   2016年3月

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    記述言語:日本語   出版者・発行元:北海道産科婦人科学会  

    医中誌

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  • 難易度の高い子宮筋腫に対する腹腔鏡手術 頸部筋腫・巨大筋腫・広間膜内発育に対する戦略的手術の分析

    西澤 庸子, 明石 祐史, 玉手 雅人, 杉尾 明香, 森下 美幸, 馬場 剛, 遠藤 俊明, 齋藤 豪

    北海道産科婦人科学会会誌   60 ( 1 )   66 - 66   2016年3月

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    記述言語:日本語   出版者・発行元:北海道産科婦人科学会  

    医中誌

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  • Three cases of unexplained recurrent pregnancy loss with different results for chromosome analysis of chorionic villi

    Toshiaki Endo, Tsuyoshi Baba, Yoshika Kuno, Miyuki Morishita, Masahito Mizuuchi, Shinichi Ishioka, Tamotsu Kiya, Tsuyoshi Saito

    JOURNAL OF REPRODUCTIVE IMMUNOLOGY   112   129 - 129   2015年11月

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    記述言語:英語   掲載種別:研究発表ペーパー・要旨(国際会議)  

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  • 腹腔鏡下子宮全摘出術におけるReduced port surgey(RPS)の導入 RPS適応拡大へ向けて

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    産婦人科手術   ( 26 )   173 - 173   2015年6月

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    記述言語:日本語   出版者・発行元:(株)メジカルビュー社  

    医中誌

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  • 手術手技研究会のサマリー 子宮卵巣全摘出術のパラダイムシフトと性別適合手術としての全腹腔鏡下子宮全摘出術

    明石 祐史, 玉手 雅人, 足立 英文, 杉尾 明香, 森下 美幸, 馬場 剛, 遠藤 俊明, 斎藤 豪, 舛森 直哉

    GID(性同一性障害)学会雑誌   7 ( 1 )   105 - 108   2014年12月

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    記述言語:日本語   出版者・発行元:GID(性同一性障害)学会  

    医中誌

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  • 性別適合手術としての全腹腔鏡下子宮全摘出術の検討 低侵襲化の光と影

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    北日本産科婦人科学会総会・学術講演会プログラム・抄録集   62回   49 - 49   2014年9月

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    記述言語:日本語   出版者・発行元:東北連合産科婦人科学会・北日本産科婦人科学会  

    医中誌

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  • FDAの勧告を鑑みていまあらためて考える子宮の回収法 婦人科腹腔鏡手術におけるBagging法によるモルセレーションの可能性

    明石 祐史, 玉手 雅人, 杉尾 明香, 森下 美幸, 馬場 剛, 遠藤 俊明, 斎藤 豪

    日本産科婦人科内視鏡学会雑誌   30 ( Suppl.I )   201 - 201   2014年8月

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    記述言語:日本語   出版者・発行元:(一社)日本産科婦人科内視鏡学会  

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  • 子宮鏡観察モデルの作成方法

    森下 美幸, 玉手 雅人, 杉尾 明香, 明石 祐史, 馬場 剛, 遠藤 俊明, 斉藤 豪

    日本産科婦人科内視鏡学会雑誌   30 ( Suppl.I )   262 - 262   2014年8月

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    記述言語:日本語   出版者・発行元:(一社)日本産科婦人科内視鏡学会  

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  • 腹腔鏡下卵巣子宮内膜症性嚢胞核出術に対する希釈バソプレッシン注入法の効果と妊孕能への影響

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    日本産科婦人科内視鏡学会雑誌   30 ( Suppl.I )   158 - 158   2014年8月

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    記述言語:日本語   出版者・発行元:(一社)日本産科婦人科内視鏡学会  

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  • 子宮内膜症合併不妊患者の腹腔内評価が治療方針に与える影響について

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    日本産科婦人科内視鏡学会雑誌   30 ( Suppl.I )   162 - 162   2014年8月

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    記述言語:日本語   出版者・発行元:(一社)日本産科婦人科内視鏡学会  

    医中誌

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  • ヘテロ型先天性プロテインC欠損症合併妊娠に対し抗凝固療法を用いて周産期管理を行った一例

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    北海道産科婦人科学会会誌   56 ( 1 )   38 - 42   2012年3月

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    記述言語:日本語   出版者・発行元:北海道産科婦人科学会  

    医中誌

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  • First case of vaginal radical trachelectomy in a pregnant Japanese woman

    IWAMI Nanako, ISHIOKA Shin-ichi, ENDO Toshiaki, BABA Tsuyoshi, NAGASAWA Kunihiko, TAKAHASHI Madoka, SUGIO Asuka, TAKADA Sakura, MARIYA Tasuku, MIZUNUMA Masahiro, SAITO Tsuyoshi

    International journal of clinical oncology   16 ( 6 )   737 - 740   2011年12月

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  • Pregnancy-related complications after vaginal radical trachelectomy for early-stage invasive uterine cervical cancer

    ISHIOKA Shin-ichi, ENDO Toshiaki, HAYASHI Takuhiro, BABA Tsuyoshi, UMEMURA Kota, SAITO Tsuyoshi

    International journal of clinical oncology : official journal of the Japan Society of Clinical Oncology   12 ( 5 )   350 - 355   2007年10月

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    記述言語:英語  

    PubMed

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  • 多嚢胞性卵巣症候群とインスリン抵抗性関連遺伝子の多型

    馬場 剛, 遠藤 俊明, 本間 寛之, 北島 義盛, 松浦 基樹, 南 妃奈, 西川 聡, 石岡 伸一, 林 卓宏, 金谷 美加, 真名瀬 賢吾, 佐田 文宏, 岸 玲子, 山田 秀人, 水上 尚典, 神谷 博文, 森若 治, 齋藤 豪

    日本内分泌学会雑誌   82 ( 4 )   864 - 864   2007年3月

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    記述言語:日本語   出版者・発行元:(一社)日本内分泌学会  

    医中誌

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  • 多嚢胞性卵巣症候群とインスリン抵抗性関連遺伝子の多型

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    日本産科婦人科学会雑誌   59 ( 2 )   569 - 569   2007年2月

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    記述言語:日本語   出版者・発行元:(公社)日本産科婦人科学会  

    医中誌

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  • Delayed postpartum hemorrhage due to cesarean scar dehiscence 国際誌

    Tsuyoshi Baba, Miyuki Morishita, Masami Nagata, Yasushi Yamakawa, Masahiro Mizunuma

    Archives of Gynecology and Obstetrics   272 ( 1 )   82 - 83   2005年6月

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  • Epidermal growth factor increased the expression of alpha 2 beta 1-integrin and modulated integrin-mediated signaling in human cervical adenocarcinoma cells 国際誌

    Yamanaka, I, M Koizumi, T Baba, S Yamashita, T Suzuki, R Kudo

    EXPERIMENTAL CELL RESEARCH   286 ( 2 )   165 - 174   2003年6月

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  • Imaging studies in patients with malignant melanoma in the female genital tract

    M Takehara, T Saito, H Mizumoto, T Baba, R Tanaka, T Fujimoto, K Adachi, R Kudo

    INTERNATIONAL JOURNAL OF GYNECOLOGICAL CANCER   12 ( 5 )   506 - 509   2002年9月

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  • Specific detection of circulating tumor cells by reverse transcriptase-polymerase chain reaction of a beta-casein-like protein, preferentially expressed in malignant neoplasms

    T Baba, M Koizumi, T Suzuki, Yamanaka, I, S Yamashita, R Kudo

    ANTICANCER RESEARCH   21 ( 4A )   2547 - 2551   2001年7月

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    記述言語:英語  

    Web of Science

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  • Cloning and characterization of a tumor-associated antigen, beta-casein-like protein

    T Baba, M Koizumi, T Suzuki, Yamanaka, I, S Yamashita, R Kudo

    BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS   284 ( 2 )   340 - 345   2001年6月

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  • A case of Stage-IVb cervical adenocarcinoma successfully treated by combination chemotherapy: Case report

    Masaki Takehara, Yoshihiro Nishioka, Tsuyoshi Saito, Tsuyoshi Baba, Takahiro Suzuki, Eiki Ito, Ryuichi Kudo

    Journal of Obstetrics and Gynaecology Research   26 ( 2 )   133 - 136   2000年

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    記述言語:英語   出版者・発行元:University of Tokyo Press  

    DOI: 10.1111/j.1447-0756.2000.tb01296.x

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  • Surgical management of genital prolapse: Is chain cystourethrography useful for evaluating anatomical corrections and urinary symptoms after surgery?

    T. Baba, M. Koizumi, R. Tanaka, S. Yamashita, M. Noda, I. Yamanaka, T. Suzuki, E. Ito, R. Kudo

    Journal of Obstetrics and Gynaecology Research   26 ( 4 )   289 - 294   2000年

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    記述言語:英語   出版者・発行元:University of Tokyo Press  

    DOI: 10.1111/j.1447-0756.2000.tb01324.x

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▼全件表示

共同研究・競争的資金等の研究課題

  • 胎児期から続く化学物質によるリプロダクティブヘルスへの影響:分子機構の解明を含む

    研究課題/領域番号:25H01076  2025年4月 - 2029年3月

    日本学術振興会  科学研究費助成事業  基盤研究(A)

    岸 玲子, アイツバマイ ゆふ, 山口 健史, 伊藤 佐智子, 岩田 啓芳, 牧野 圭太郎, 田村 菜穂美, 馬場 剛, 齊藤 良玄, 江口 哲史, 今 雅史, 村西 雄貴, 平田 由里絵

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    配分額:60060000円 ( 直接経費:46200000円 、 間接経費:13860000円 )

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  • 遺伝子多型は多嚢胞性卵巣症候群の疾患感受性、薬剤応答性を規定する

    研究課題/領域番号:20791154  2008年 - 2010年

    日本学術振興会  科学研究費助成事業  若手研究(B)

    馬場 剛

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    配分額:4030000円 ( 直接経費:3100000円 、 間接経費:930000円 )

    インスリン抵抗性関連遺伝子の一塩基多型(SNP)のうち、IRS-1Gly972Arg、RETN-420C/GがPCOSの疾患感受性遺伝子であることが判明した。一方、ENPP1 Lys121Gln、apM1-11377C/Gの遺伝子型頻度に関しては、PCOS症例とコントロール症例において、有意差は認められなかった。PCOS症例において、RETN homogeneous variant genotypeをもつものでは有意にBMI高値、空腹時インスリン高値、Adiponectin低値であったが、IRS-1 genotypeによる差異は認められなかった。

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  • 多嚢胞性卵巣症候群におけるインスリン抵抗性

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    資金種別:競争的資金

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