Degree 【 display / non-display 】

Degree 【 display / non-display 】

• MD, PhD

Research Experience 【 display / non-display 】

Research Experience 【 display / non-display 】

• 2022.06

  -

  Now

  Sapporo Medical University   Department of Dermatology   Associate Professor

• 2014.04

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  2022.05

  Sapporo Medical University   Department of Dermatology   Assistant Professor

• 2005.08

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  2007.08

  St George's University of London   Basic Medical Sciences   Visiting Research Fellow

  Visiting Research Fellow

• 2005.04

  -

  2014.03

  Sapporo Medical University   Department of Dermatology   Instructor

  Instructor

• 2002.04

  -

  2005.03

  Sapporo Medical University   Department of Dermatology   Resident

  Resident

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Professional Memberships 【 display / non-display 】

Professional Memberships 【 display / non-display 】

• 　

  　

  　

  The Japanese Society for Plgment Cell Research

• 　

  　

  　

  THE JAPANESE SOCIETY FOR INVESTIGATIVE DERMATOLOGY

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  The Japanese Society of Recklinghausen disease

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  JAPANESE DERMATOLOGICAL ASSOCIATION

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  Japanese Skin Cancer Society

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Research Areas 【 display / non-display 】

Research Areas 【 display / non-display 】

• Life sciences   Medical biochemistry   clinical genetics

• Life sciences   Dermatology   skin cancers

• Life sciences   Dermatology   melanogenesis

Affiliation 【 display / non-display 】

Affiliation 【 display / non-display 】

• Sapporo Medical University   School of Medicine, Dept.of Dermatology   Associate Professor   病院教授  

Research Interests 【 display / non-display 】

Research Interests 【 display / non-display 】

• clinical genetics

• genetics

• melanoma

• melanin

• genodermatosis

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Papers 【 display / non-display 】

Papers 【 display / non-display 】

• Dominant inheritance in hereditary angioedema associated with carboxypeptidase N deficiency.

  Tokimasa Hida, Masashi Idogawa, Masae Okura, Takashi Tokino, Hisashi Uhara

  Allergology international : official journal of the Japanese Society of Allergology    2025.04  [Refereed]  [International journal]

  DOI PubMed

• Genomic profiling and personalized treatment strategies for skin malignancies: findings from the center for cancer genomics and advanced therapeutics database.

  Tokimasa Hida

  International journal of clinical oncology    2025.03  [Refereed]  [Domestic journal]

  　View Summary

  Immune checkpoint inhibitors and molecular-targeted therapies have dominated recent cancer treatment. However, these treatments face challenges, such as primary and acquired resistance, indicating that not all patients benefit from them. Therefore, the search for new molecular targets is crucial. In addition, immune checkpoint inhibitors have exhibited racial differences in their effectiveness for certain neoplasms. Hence, understanding the genomic landscape of cancers in various racial groups is important. In Japan, health insurance has covered comprehensive genomic profiling since 2019, and the Center for Cancer Genomics and Advanced Therapeutics (C-CAT) has accumulated genetic abnormalities along with clinical data of patients with various cancers. These data are crucial for advancing cancer research and drug development. This review discusses the genetic abnormalities of the major skin malignancies including melanoma, cutaneous squamous cell carcinoma (cSCC), and extramammary Paget's disease (EMPD), and proposes potential treatment strategies by comparing C-CAT data analysis with other genetic studies. The C-CAT data have emphasized unique genetic alterations in tumors of the Japanese population, particularly racial differences in tumor mutational burden in cutaneous melanoma and cSCC, indicating the importance of personalized treatment strategies that consider racial differences.

  DOI PubMed

• Efficacy of eribulin monotherapy for bone marrow carcinomatosis of breast cancer in a patient with Werner syndrome.

  Akihito Fujimi, Yasuhiro Nagamachi, Naofumi Yamauchi, Riku Hasebe, Naoki Onoyama, Naotaka Hayasaka, Teppei Matsuno, Kazuhiko Koike, Yoshiro Gotoh, Kohji Ihara, Junji Kato, Takuji Nishisato, Kazuyuki Murase, Goro Kutomi, Tokimasa Hida, Hisashi Uhara, Kohichi Takada

  Geriatrics & gerontology international    2025.01  [Refereed]  [Domestic journal]

  　View Summary

  Various complications and potential risks of serious adverse events lessens the intensity of chemotherapy in patients with Werner syndrome. Bone marrow carcinomatosis of breast cancer was developed in a patient with Werner syndrome. Eribulin proved well tolerated and effective in improving severe thrombocytopenia, leading to platelet transfusion-free status.

  DOI PubMed

• Joining PCMR: Aspirations for Editorial Contributions.

  Tokimasa Hida

  Pigment cell & melanoma research   38 ( 1 ) e70000  2025.01  [International journal]

  DOI PubMed

• The genomic landscape of cutaneous squamous cell carcinoma in Japan.

  Junji Kato, Tokimasa Hida, Masashi Idogawa, Takashi Tokino, Hisashi Uhara

  The Journal of dermatology    2024.12  [Refereed]  [International journal]

  　View Summary

  Comprehensive studies of the genetic profiles of cutaneous squamous cell carcinoma (cSCC) in Japanese patients have been lacking, although an understanding of these profiles is crucial for improving treatment outcomes. Since 2019, comprehensive genomic profiling (CGP) has been covered by Japan's health insurance, and the resulting data have been compiled into a comprehensive database by the country's Center for Cancer Genomics and Advanced Therapeutics (C-CAT). In this retrospective study, we used CGP data from the C-CAT database to analyze genomic characteristics of cSCC in Japanese patients. The patients' clinical and genomic data, including the chemotherapy regimens, tumor mutational burden (TMB), and survival status, were obtained. We analyzed the cases of 152 patients, with only those evaluated by the FoundationOne® CDx included for accuracy. Among the 152 patients, the most common gene oncogenic alterations were observed in TP53 (67%), CDKN2A (54%), TERT (49%), CDKN2B (33%), and NOTCH1 (18%). TMB-high (≥10 mut/Mb) was observed in 27% (n = 41) of the patients, with a median age of 75 years for this group. TMB-low (<10 mut/Mb) was observed in 73% (n = 111) of the patients; their median age was 67 years.

  DOI PubMed

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Misc 【 display / non-display 】

Misc 【 display / non-display 】

• 1.日本人のメラノーマの遺伝子異常と治療戦略

  肥田時征, 宇原久

  日本皮膚科学会雑誌   135 ( 2 )  2025

  J-GLOBAL

• 日本皮膚科学会ガイドライン 皮膚がん診療ガイドライン第4版 メラノーマ診療ガイドライン2025

  福島 聡, 伊東 孝通, 浅井 純, 井垣 浩, 田中 亮多, 並川 健二郎, 林 礼人, 皆川 茜, 宮川 卓也, 宮下 梓, 緒方 大, 奥村 真央, 木庭 幸子, 後藤 寛之, 並木 剛, 橋本 弘規, 肥田 時征, 平田 岳郎, 前田 拓, 松澤 高光, 柳 輝希, 杉本 香苗, 木村 絵美, 古賀 弘志, 内 博史, 宮垣 朝光, 中村 泰大, 猪爪 隆史, 公益社団法人日本皮膚科学会, 一般社団法人日本皮膚悪性腫瘍学会, 皮膚がん診療ガイドライン策定委員会(メラノーマ診療ガイドライングループ)

  日本皮膚科学会雑誌 ( (公社)日本皮膚科学会 )  134 ( 13 ) 3149 - 3265  2024.12

• メラノジェネシス標的低分子NPrCAPとナノマグネタイト粒子結合による次世代型低侵襲性メラノーマ化学・温熱・免疫療法(CTI療法)の産学共同開発

  神保 孝一, 肥田 時征, 川上 聡経, 伊藤 祥輔, 若松 一雅, 井藤 彰, 本多 裕之, 田村 保明, 鳥越 俊彦

  日本皮膚科学会雑誌 ( (公社)日本皮膚科学会 )  134 ( 12 ) 3017 - 3034  2024.11

  　View Summary

  悪性黒色腫,メラノーマの欧米白人に対する治療法は免疫チェックポイント阻害薬,分子標的薬の導入により画期的転換を迎えた.しかし病型が異なる日本人症例に対する有用性は乏しく,新規治療法開発が喫緊の課題である.我々はメラノーマに特異的な代謝経路,メラノジェネシスのメラニン前駆物質であるチロシン(フェノール)誘導体,NPrCAPを合成し,マグネタイト粒子と結合させ,産学共同研究を行うことにより次世代型低侵襲性化学・温熱・免疫(CTI)療法を樹立した.新規薬剤開発,作用機序,臨床治験につき報告する.(著者抄録)

• 【メラノーマ診療Up-To-Date】メラノーマの治療選択における包括的がんゲノムプロファイリング検査

  肥田 時征, 加藤 潤史, 井戸川 雅史, 宇原 久

  皮膚病診療 ( (株)協和企画 )  46 ( 1 ) 28 - 33  2024.01

  　View Summary

  ＜文献概要＞ポイント ●包括的がんゲノムプロファイリング(comprehensive genome profiling:CGP,別名:がん遺伝子パネル)検査は,標準治療の終了した(または終了見込みの)固形癌患者が保険診療で受けることができ,現在5種類から選択できる.●CGP検査のエキスパートパネルで非承認薬や適応外薬が推奨された場合,その薬を使用するためには治験,先進医療,臨床研究などに参加する必要がある.●メラノーマでは,BRAFのまれな変異,融合遺伝子,KIT変異などが治療標的として検出される可能性がある.

• 【新規知見の乏しい皮膚疾患】aquagenic wrinkling of the palmsの2例

  小松 彩友香, 肥田 時征, 黄倉 真恵, 宇原 久

  皮膚病診療 ( (株)協和企画 )  45 ( 9 ) 802 - 805  2023.09

  　View Summary

  ＜文献概要＞症例のポイント ・aquagenic wrinkling of the palmsは手掌を浸水させると容易に白色浸軟化し,ときおり疼痛を伴う後天性の疾患である.治療法は確立されていない.・掌蹠に角化を伴う場合,本邦で頻度の高い長島型掌蹠角化症も鑑別になるが,そのほかに特徴的な臨床症状を伴い,SERPINB7遺伝子に病原性バリアントが検出される.

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Research Projects 【 display / non-display 】

Research Projects 【 display / non-display 】

• Comprehensive analysis of genetic mutations and fusions in Japanese melanoma

  Grant-in-Aid for Scientific Research (C)

  Project Year :

  2021.04

  -

  2024.03

   

  肥田 時征, 井戸川 雅史

• 美白化合物のメラノーマ細胞障害作用を利用した新規メラノーマ治療薬の開発

  奨励研究

  Project Year :

  2019

  　

  　

   

  黄倉 真恵, 宇原 久, 肥田 時征

  　View Summary

  BRAF遺伝子変異を有するメラノーマには分子標的薬が奏効するものの、のちに薬剤耐性が生じる場合が多い。本研究は、分子標的薬の耐性をアスコルビン酸、ロドデノールの併用で克服できるかどうかを検討した。結果、アスコルビン酸はBRAF/MEK阻害剤耐性メラノーマ細胞株SK-me1-23DT, ロドデノールはBRAF/MEK阻害剤耐性メラノーマ細胞株A375DTに強い細胞障害を誘発した。以上の結果から、アスコルビン酸とロドデノールは、分子標的薬(BRAF/MEK阻害薬)による耐性を克服しうる治療薬の候補となり得ることがわかった。

• Identification and analysis of tumor-associated genes of melanoma by functional assay

  Grant-in-Aid for Scientific Research (C)

  Project Year :

  2013.04

  -

  2016.03

   

  Yamashita Toshiharu

  　View Summary

  We aimed to examine the epigenetically silenced miRNA and its involvement in the induction of apoptosis of cultured melanoma cells. A screen for miRNAs induced by 5-aza-2’deoxycytidine (5-aza-dC) and interferon-beta (IFN-β) in TXM18 melanoma cells identified six species of miRNAs including miR-7, miR-203, miR-215 and miR-596. The CpG island of the miR-596 gene was strongly methylated in all melanoma cell lines tested (n = 20) whereas methylation levels were limited in melanocytes (n=4). Transfection of a precursor of miR-596 into melanoma cells induced growth suppression, indicating that the effect of 5-aza-dC plus IFN-β is in part due to induction of miR-596. Methylation levels of miR-596 were significantly higher in clinical specimens of melanoma as compared to benign melanocytic nevi.

• Analysis of melanosome transfer between melanocytes and keratinocytes

  Grant-in-Aid for Young Scientists (B)

  Project Year :

  2011

  -

  2013

   

  HIDA Tokimasa

  　View Summary

  A new co-culture method for melanocytes and keratinocytes has been developed. By using this method, melanosomal transfer from melanocytes to keratinocytes could be visualized with electron and optical microscopes and the melanin content of transferred melanosomes could be analyzed. The effect of inhibitors of melanin synthesis on melanosomal transfer could also be analyzed. To apply the result for clinical practice, the melanin distribution in the nipple skin of patients with pigmented mammary Paget's disease was examined with histopathology, immunohistochemistry and dermoscopy. It was suggested that tumor cells transferred melanin from reactive melanocytes are subject to passive elimination from the epidermis and form characteristic dermoscopic patterns. This finding is useful in diagnosing pigmented mammary Paget's disease.

• Development of novel melanoma therapy targeting SIRT1

  Grant-in-Aid for Scientific Research (C)

  Project Year :

  2010

  -

  2012

   

  YAMASITA Tosiharu, HORIO Yosiyuki, HIDA Tokimasa

  　View Summary

  SIRT1 was localized in the cytoplasm of melanoma cells and the SIRT1 inhibitor nicotinamide suppressed their migration. SIRT1 was detected with F -actin in the protuberance of the cell membrane and accumulated with PIP-3 and AKT. Nicotinamide inhibited the peritoneal invasion and lymph node metastasis of transplanted B16F1 cells in C57BL mice and extended their life span. These results indicate that SIRT1 inhibition may be applicable for the suppression of metastatic melanoma.

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Presentations 【 display / non-display 】

Presentations 【 display / non-display 】

• RNA-based multiplex polymerase chain reaction and sequencing to detect fusion genes in melanoma

  Hida T., Idogawa M., Kato J., Horimoto K., Sato S., Kiniwa Y., Sugita S., Okura M., Okuyama R., Tokino T., Uhara H.

  ESMO Asia Congress 2024, Singapore 

  Presentation date： 2024.12

  Event date：

  2024.12

  　

  　

• Mutation landscape of melanomas among Japanese: Custom panel sequencing of 77 cases

  Hida T, Idogawa M, Kato J, Horimoto K, Sato S, Kiniwa Y, Okura M, Okuyama R, Tokino T, Uhara H

  25th World Congress of Dermatology 

  Presentation date： 2023.07

  Event date：

  2023.07

  　

  　

• Copy number variations and fusion genes in driver mutation-negative melanoma

  Hida T, Idogawa M, Kato J, Horimoto K, Sato S, Kiniwa Y, Sugita S, Okura M, Okuyama R, Tokino T, Uhara H

  25th International Pigment Cell Conference 

  Presentation date： 2023.05

  Event date：

  2023.05

  -

  2023.06

• 線状の脱色素斑を伴ったfamilial progressive hyperpigmentation with or without hypopigmentationの１例

  肥田時征, 宇原 久

  第31回日本色素細胞学会学術大会 

  Presentation date： 2022.11

  Event date：

  2022.11

  　

  　

• 教育講演. 神経線維腫症1型 up date

  肥田 時征  [Invited]

  第424回日本皮膚科学会北海道地方会 

  Presentation date： 2020.12

  Event date：

  2020.12

  　

  　

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Committee Memberships 【 display / non-display 】

Committee Memberships 【 display / non-display 】

• 2024

  -

  Now

    Councilor

• 2020

  -

  Now

    Councilor

• 2018.04

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  Now

    特別委員

• 2017.12

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  Now

    Councilor