MIYAZAKI Akihiro

写真a

Affiliation

School of Medicine, Department of Oral Surgery

Job title

Professor
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Education 【 display / non-display 】

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    1991

    Hokkaido University  

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    1991

    Hokkaido University  

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Degree 【 display / non-display 】

  • PhD(Medical Science)

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Professional Memberships 【 display / non-display 】

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    Japan Society for Oral Tumors

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    Japanese Society of Oral & Maxillofacial Surgeons

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    The International Association of Oral and Maxillofacial Surgeons

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    日本口腔外科学会

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    The Japanese Stomatological Society

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Affiliation 【 display / non-display 】

  • Sapporo Medical University   School of Medicine, Dept.of Oral Surgery   Instructor  

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Research Interests 【 display / non-display 】

  • 口腔外科学

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Papers 【 display / non-display 】

  • Quantitative Evaluation of Cephalometric Radiographs of Patients With Hemifacial Microsomia.

    Tokura TA, Miyazaki A, Igarashi T, Dehari H, Kobayashi JI, Miki Y, Ogi K, Sonoda T, Yotsuyanagi T, Hiratsuka H

    The Cleft palate-craniofacial journal : official publication of the American Cleft Palate-Craniofacial Association   56 ( 6 ) 711 - 719  2019.07  [Refereed]

    DOI PubMed

  • Selective Neck Dissection and Survival in Pathologically Node-Positive Oral Squamous Cell Carcinoma.

    Shimura S, Ogi K, Miyazaki A, Shimizu S, Kaneko T, Sonoda T, Kobayashi J, Igarashi T, Miyakawa A, Hasegawa T, Hiratsuka H

    Cancers ( MDPI AG )  11 ( 2 ) 269 - 269  2019.02  [Refereed]

    　View Summary

    The most important prognostic factor in oral squamous cell carcinoma (OSCC) is neck metastasis, which is treated by neck dissection. Although selective neck dissection (SND) is a useful tool for clinically node-negative OSCC, its efficacy for neck node-positive OSCC has not been established. Sixty-eight OSCC patients with pN1–3 disease who were treated with curative surgery using SND and/or modified-radical/radical neck dissection (MRND/RND) were retrospectively reviewed. The neck control rate was 94% for pN1–3 patients who underwent SND. The five-year overall survival (OS) and disease-specific survival (DSS) in pN1-3 OSCC patients were 62% and 71%, respectively. The multivariate analysis of clinical and pathological variables identified the number of positive nodes as an independent predictor of SND outcome (OS, hazard ratio (HR) = 4.98, 95% confidence interval (CI): 1.48–16.72, p < 0.01; DSS, HR = 6.44, 95% CI: 1.76–23.50, p < 0.01). The results of this retrospective study showed that only SND for neck node-positive OSCC was appropriate for those with up to 2 lymph nodes that had a largest diameter ≤3 cm without extranodal extension (ENE) of the neck and adjuvant radiotherapy. However, the availability of postoperative therapeutic options for high-risk OSCC, including ENE and/or multiple positive lymph nodes, needs to be further investigated.

    DOI PubMed

  • Tumor-infiltrating CD8<sup>+</sup> T-cell density is an independent prognostic marker for oral squamous cell carcinoma.

    Shimizu S, Hiratsuka H, Koike K, Tsuchihashi K, Sonoda T, Ogi K, Miyakawa A, Kobayashi J, Kaneko T, Igarashi T, Hasegawa T, Miyazaki A

    Cancer medicine ( Wiley )  8 ( 1 ) 80 - 93  2019.01  [Refereed]

    DOI PubMed

  • Uncommon presentation of desmoplastic fibroblastoma on the tongue of a female patient.

    Tokura T, Kobayashi JI, Okamoto JY, Miyazaki A

    BMJ case reports   2018  2018.10  [Refereed]

    DOI PubMed

  • Screening for long noncoding RNAs associated with oral squamous cell carcinoma reveals the potentially oncogenic actions of DLEU1.

    Koyo Nishiyama, Reo Maruyama, Takeshi Niinuma, Masahiro Kai, Hiroshi Kitajima, Mutsumi Toyota, Yui Hatanaka, Tomohiro Igarashi, Jun-Ichi Kobayashi, Kazuhiro Ogi, Hironari Dehari, Akihiro Miyazaki, Akira Yorozu, Eiichiro Yamamoto, Masashi Idogawa, Yasushi Sasaki, Tamotsu Sugai, Takashi Tokino, Hiroyoshi Hiratsuka, Hiromu Suzuki

    Cell death & disease   9 ( 8 ) 826 - 826  2018.08  [Refereed]  [International journal]

    　View Summary

    Recent studies have shown that long noncoding RNAs (lncRNAs) have pivotal roles in human malignancies, although their significance in oral squamous cell carcinoma (OSCC) is not fully understood. In the present study, we identified lncRNAs functionally associated with OSCC. By analyzing RNA-seq datasets obtained from primary head and neck squamous cell carcinoma (HNSCC), we identified 15 lncRNAs aberrantly expressed in cancer tissues. We then validated their expression in 18 OSCC cell lines using qRT-PCR and identified 6 lncRNAs frequently overexpressed in OSCC. Among those, we found that knocking down DLEU1 (deleted in lymphocytic leukemia 1) strongly suppressed OSCC cell proliferation. DLEU1 knockdown also suppressed migration, invasion, and xenograft formation by OSCC cells, which is suggestive of its oncogenic functionality. Microarray analysis revealed that DLEU1 knockdown significantly affects expression of a number of cancer-related genes in OSCC cells, including HAS3, CD44, and TP63, suggesting that DLEU1 regulates HA-CD44 signaling. Expression of DLEU1 was elevated in 71% of primary OSCC tissues, and high DLEU1 expression was associated with shorter overall survival of HNSCC patients. These data suggest that elevated DLEU1 expression contributes to OSCC development, and that DLEU1 may be a useful therapeutic target in OSCC.

    DOI PubMed

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Misc 【 display / non-display 】

  • Clinical study of squamous cell carcinoma of the buccal mucosa ; A review of 38 cases treated primarily by surgery.

    Akihiro MIYAZAKI, Makoto NOGUCHI, Hiromi KUBOTA, Yukie KIDO, Takashi IDE, Hiroaki KONDO, Kanako TAKEMURA, Itaru NAGAI, Hisanori KINJYO, Gen-iku KOHAMA

    pn.J.Oral Maxillofac.Surg. ( Japanese Society of Oral and Maxillofacial Surgeons )  49 ( 9 ) 527 - 532  2003

    　View Summary

    Thirty-eight patients with squamous cell carcinoma of the buccal mucosa were treated by surgery at our clinic during the 22-year period from April 1976 through March 1999. The average age of the patients was 61.1 years. The distribution of clinical stage according to the TNM (1997) classification was as follows: stage I, 5 patients; stage II, 12; stage III, 8; and stage N, 13. Thirty-one patients received preoperative chemotherapy consisting of bleomycin alone or in combination with other agents such as cisplatin, methotrexate, or 5-f luorouracil; 5 received preoperative chemoradiotherapy. Response of the primary lesion was evaluated as complete response in 5 patients and partial response in 11. All patients underwent surgical resection. Local and partial excisions were performed via the oral route in 18 patients, through and through excision in 5, and composite operation in 15. Neck lymph node metastasis was histologically confirmed in 12 patients at primary operation and secondary metastasis was confirmed in 2. Primary closure of the surgical defect was done in 10 patients. A local mucosal flap was used in 5 patients, an artifical mucous membrane such as TERUDERMIS® in 14, and a skin graft in 3. Distant flap reconstruction was required in only 6 patients. The local control rate for all patients after initial treatment was 78.9%. Five-year cumulative survival rates calculated by Kaplan-Meier's method were 76.5% for all patients, 100% for those with stage I or III disease, 72.9% for those with stage II disease, and 51.9% for those with stage IVA disease.

    DOI CiNii

  • Control of cell proliferation kinetics of tumor in neoadjuvant chemotherapy for advanced oral squamous cell carcinoma and its prognostic implications

    Makoto Noguchi, Hisanori Kinjyo, Akihiro Miyazaki, Hiromi Kubota, Geniku Kohama

    International Journal of Clinical Oncology   7 ( 3 ) 138 - 144  2002

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    Background. Few attempts have so far been made at studies of the cell proliferation kinetics of the tumor in neoadjuvant chemotherapy for head and neck cancer. We examined the effects of neoadjuvant chemotherapy for advanced oral squamous cell carcinoma in terms of the cell proliferation kinetics of the tumor, and attempted to correlate them with patients' survival. Methods. Fifty-two patients with advanced oral squamous cell carcinoma who received neoadjuvant chemotherapy followed by surgery participated in this study. Cellular DNA content and mitotic index (MI) in tissue samples were measured before and after chemotherapy, using a cell image analyzer. Results. A decrease in both mean DNA content (mean DNA) and MI (left-shift type of change in cell growth kinetics), indicating an accumulation of cancer cells in the G0-G1 phase, was found in 25 patients. An increase in mean DNA with decreased MI (right-shift type), which was found in 13 patients, appeared to be correlated with an accumulation of cancer cells in the S-G2 phase. Neither of these two types of change, which were considered to be a favorable effect, were found in 14 patients (ineffective type). Excellent survival rates were obtained in patients who showed favorable changes in cell growth kinetics (79% for patients with left-shift type and 92% for patients with right-shift type), whereas the survival rate for patients with the ineffective type was extremely poor (14%). The type of change in cell proliferation kinetics was a powerful independent prognostic indicator. Conclusion. Analysis of cell growth kinetics appears to be useful not only as a diagnostic tool to predict patient outcome but also as a means to infer the chemotherapeutic effects in oral squamous cell carcinoma.

    DOI PubMed CiNii

  • Antigenic Peptides from Squamous Cell Carcinoma Recognized by Autologous HLA-DR8-restricted CD4+ T Cells.

    Jpn. J. Cancer Res.   93   917 - 924  2002

  • Application and therapeutic result of excisional biopsy for early tongue carcinoma

    J. Jpn. Soc. Oral Tumor   13   267 - 270  2001

    DOI

  • Effects on preoperative therapy for squamous cell carcinoma of the lower alveolus and gingiva

    Hiromi Kubota, Makoto Noguchi, Akihiro Miyazaki, Yukie Kido, Hisanori Kinjyo, Tatsuru Suyama, Toshiaki Nakano, Geniku Kohama

    J. Jpn. Soc. Oral Tumor   13 ( 3 ) 81 - 88  2001

    DOI CiNii

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Research Projects 【 display / non-display 】

  • 口腔腫瘍

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