Updated on 2025/08/22

写真a

 
MIYAZAKI Akihiro
 
Organization
School of Medicine Department of Oral Surgery Professor
Title
Professor
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Degree

  • PhD(Medical Science)

Research Interests

  • 口腔外科学

Education

  • Hokkaido University

    - 1991

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  • Hokkaido University

    - 1991

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    Country： Japan

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Papers

  • Quantitative Evaluation of Cephalometric Radiographs of Patients With Hemifacial Microsomia. Reviewed

    Tokura TA, Miyazaki A, Igarashi T, Dehari H, Kobayashi JI, Miki Y, Ogi K, Sonoda T, Yotsuyanagi T, Hiratsuka H

    The Cleft palate-craniofacial journal : official publication of the American Cleft Palate-Craniofacial Association   56 ( 6 )   711 - 719   2019.7

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  • Selective Neck Dissection and Survival in Pathologically Node-Positive Oral Squamous Cell Carcinoma. Reviewed

    Shimura S, Ogi K, Miyazaki A, Shimizu S, Kaneko T, Sonoda T, Kobayashi J, Igarashi T, Miyakawa A, Hasegawa T, Hiratsuka H

    Cancers   11 ( 2 )   269 - 269   2019.2

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    Publishing type：Research paper (scientific journal)   Publisher：MDPI AG  

    The most important prognostic factor in oral squamous cell carcinoma (OSCC) is neck metastasis, which is treated by neck dissection. Although selective neck dissection (SND) is a useful tool for clinically node-negative OSCC, its efficacy for neck node-positive OSCC has not been established. Sixty-eight OSCC patients with pN1–3 disease who were treated with curative surgery using SND and/or modified-radical/radical neck dissection (MRND/RND) were retrospectively reviewed. The neck control rate was 94% for pN1–3 patients who underwent SND. The five-year overall survival (OS) and disease-specific survival (DSS) in pN1-3 OSCC patients were 62% and 71%, respectively. The multivariate analysis of clinical and pathological variables identified the number of positive nodes as an independent predictor of SND outcome (OS, hazard ratio (HR) = 4.98, 95% confidence interval (CI): 1.48–16.72, p < 0.01; DSS, HR = 6.44, 95% CI: 1.76–23.50, p < 0.01). The results of this retrospective study showed that only SND for neck node-positive OSCC was appropriate for those with up to 2 lymph nodes that had a largest diameter ≤3 cm without extranodal extension (ENE) of the neck and adjuvant radiotherapy. However, the availability of postoperative therapeutic options for high-risk OSCC, including ENE and/or multiple positive lymph nodes, needs to be further investigated.

    DOI： 10.3390/cancers11020269

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  • Tumor-infiltrating CD8<sup>+</sup> T-cell density is an independent prognostic marker for oral squamous cell carcinoma. Reviewed

    Shimizu S, Hiratsuka H, Koike K, Tsuchihashi K, Sonoda T, Ogi K, Miyakawa A, Kobayashi J, Kaneko T, Igarashi T, Hasegawa T, Miyazaki A

    Cancer medicine   8 ( 1 )   80 - 93   2019.1

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    Publishing type：Research paper (scientific journal)   Publisher：Wiley  

    DOI： 10.1002/cam4.1889

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  • Uncommon presentation of desmoplastic fibroblastoma on the tongue of a female patient. Reviewed

    Tokura T, Kobayashi JI, Okamoto JY, Miyazaki A

    BMJ case reports   2018   2018.10

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  • Screening for long noncoding RNAs associated with oral squamous cell carcinoma reveals the potentially oncogenic actions of DLEU1. Reviewed International journal

    Koyo Nishiyama, Reo Maruyama, Takeshi Niinuma, Masahiro Kai, Hiroshi Kitajima, Mutsumi Toyota, Yui Hatanaka, Tomohiro Igarashi, Jun-Ichi Kobayashi, Kazuhiro Ogi, Hironari Dehari, Akihiro Miyazaki, Akira Yorozu, Eiichiro Yamamoto, Masashi Idogawa, Yasushi Sasaki, Tamotsu Sugai, Takashi Tokino, Hiroyoshi Hiratsuka, Hiromu Suzuki

    Cell death & disease   9 ( 8 )   826 - 826   2018.8

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    Language：English   Publishing type：Research paper (scientific journal)  

    Recent studies have shown that long noncoding RNAs (lncRNAs) have pivotal roles in human malignancies, although their significance in oral squamous cell carcinoma (OSCC) is not fully understood. In the present study, we identified lncRNAs functionally associated with OSCC. By analyzing RNA-seq datasets obtained from primary head and neck squamous cell carcinoma (HNSCC), we identified 15 lncRNAs aberrantly expressed in cancer tissues. We then validated their expression in 18 OSCC cell lines using qRT-PCR and identified 6 lncRNAs frequently overexpressed in OSCC. Among those, we found that knocking down DLEU1 (deleted in lymphocytic leukemia 1) strongly suppressed OSCC cell proliferation. DLEU1 knockdown also suppressed migration, invasion, and xenograft formation by OSCC cells, which is suggestive of its oncogenic functionality. Microarray analysis revealed that DLEU1 knockdown significantly affects expression of a number of cancer-related genes in OSCC cells, including HAS3, CD44, and TP63, suggesting that DLEU1 regulates HA-CD44 signaling. Expression of DLEU1 was elevated in 71% of primary OSCC tissues, and high DLEU1 expression was associated with shorter overall survival of HNSCC patients. These data suggest that elevated DLEU1 expression contributes to OSCC development, and that DLEU1 may be a useful therapeutic target in OSCC.

    DOI： 10.1038/s41419-018-0893-2

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  • Diverticulum of the buccal mucosa: A rare case report and review of the literature Reviewed

    Akihiro Miyazaki, Sho Miyamoto, Hiromi Nakai, Koyo Nishiyama, Kei Tsuchihashi, Jun-ichi Kobayashi, Kazuhiro Ogi, Hironari Dehari, Tadashi Hasegawa, Hiroyoshi Hiratsuka

    BMC Oral Health   18 ( 1 )   102   2018.6

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    Language：English   Publishing type：Research paper (scientific journal)   Publisher：BioMed Central Ltd.  

    DOI： 10.1186/s12903-018-0572-9

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  • LpMab-23-recognizing cancer-type podoplanin is a novel predictor for a poor prognosis of early stage tongue cancer Reviewed

    Akihiro Miyazaki, Hiromi Nakai, Tomoko Sonoda, Yoshihiko Hirohashi, Mika K. Kaneko, Yukinari Kato, Yoshihiko Sawa, Hiroyoshi Hiratsuka

    Oncotarget   9 ( 30 )   21156 - 21165   2018.4

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    Language：English   Publishing type：Research paper (scientific journal)   Publisher：Impact Journals LLC  

    DOI： 10.18632/oncotarget.24986

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  • Tumor budding is an independent prognostic marker in early stage oral squamous cell carcinoma: With special reference to the mode of invasion and worst pattern of invasion Reviewed

    Shota Shimizu, Akihiro Miyazaki, Tomoko Sonoda, Kazushige Koike, Kazuhiro Ogi, Jun-ichi Kobayashi, Takeshi Kaneko, Tomohiro Igarashi, Megumi Ueda, Hironari Dehari, Akira Miyakawa, Tadashi Hasegawa, Hiroyoshi Hiratsuka

    PLoS ONE   13 ( 4 )   e0195451   2018.4

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    Language：English   Publishing type：Research paper (scientific journal)   Publisher：Public Library of Science  

    DOI： 10.1371/journal.pone.0195451

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  • The antigen ASB4 on cancer stem cells serves as a target for CTL immunotherapy of colorectal cancer Reviewed

    Sho Miyamoto, Vitaly Kochin, Takayuki Kanaseki, Ayumi Hongo, Serina Tokita, Yasuhiro Kikuchi, Akari Takaya, Yoshihiko Hirohashi, Tomohide Tsukahara, Takeshi Terui, Kunihiko Ishitani, Fumitake Hata, Ichiro Takemasa, Akihiro Miyazaki, Hiroyoshi Hiratsuka, Noriyuki Sato, Toshihiko Torigoe

    Cancer Immunology Research   6 ( 3 )   358 - 369   2018.3

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    Language：English   Publishing type：Research paper (scientific journal)   Publisher：American Association for Cancer Research Inc.  

    DOI： 10.1158/2326-6066.CIR-17-0518

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  • Additive effect of radiosensitization by 2-deoxy-D-glucose delays DNA repair kinetics and suppresses cell proliferation in oral squamous cell carcinoma Reviewed

    Mayumi Kawata, Kazuhiro Ogi, Koyo Nishiyama, Sho Miyamoto, Takafumi Nakagaki, Makoto Shimanishi, Akihiro Miyazaki, Hiroyoshi Hiratsuka

    JOURNAL OF ORAL PATHOLOGY & MEDICINE   46 ( 10 )   979 - 985   2017.11

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    Language：English   Publishing type：Research paper (scientific journal)  

    DOI： 10.1111/jop.12606

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  • Induction and Analysis of Cytotoxic T-Lymphocytes that Recognize Autologous Oral Squamous Cell Carcinoma Reviewed

    Jun-Ya Okamoto, Akihiro Miyazaki, Jun-Ichi Kobayashi, Sho Miyamoto, Takanori Sasaki, Takayuki Kanaseki, Yoshihiko Hirohashi, Toshihiko Torigoe, Hiroyoshi Hiratsuka

    ANTICANCER RESEARCH   37 ( 9 )   4889 - 4897   2017.9

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    Language：English   Publishing type：Research paper (scientific journal)  

    DOI： 10.21873/anticanres.11898

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  • Relationship between mandibular ramus height and masticatory muscle function in patients with unilateral hemifacial microsomia Reviewed

    Naohiro Suzuki, Akihiro Miyazaki, Tomohiro Igarashi, Hironari Dehari, Jun-Ichi Kobayashi, Yoshiki Miki, Kazuhiro Ogi, Itaru Nagai, Tomoko Sonoda, Takatoshi Yotsuyanagi, Hiroyoshi Hiratsuka

    Cleft Palate-Craniofacial Journal   54 ( 1 )   43 - 52   2017.1

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    Language：English   Publishing type：Research paper (scientific journal)   Publisher：American Cleft Palate Craniofacial Association  

    DOI： 10.1597/14-329

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  • Hypoxia-induced epithelial-mesenchymal transition is regulated by phosphorylation of GSK3-beta via PI3 K/Akt signaling in oral squamous cell carcinoma Reviewed

    Takeshi Kaneko, Hironari Dehari, Takanori Sasaki, Tomohiro Igarashi, Kazuhiro Ogi, Jun-ya Okamoto, Mayumi Kawata, Jun-ichi Kobayashi, Akihiro Miyazaki, Kenji Nakamori, Hiroyoshi Hiratsuka

    ORAL SURGERY ORAL MEDICINE ORAL PATHOLOGY ORAL RADIOLOGY   122 ( 6 )   719 - 730   2016.12

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    Language：English   Publishing type：Research paper (scientific journal)  

    DOI： 10.1016/j.oooo.2016.06.008

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  • Microenvironmental stresses induce HLA-E/Qa-1 surface expression and thereby reduce CD8(+) T-cell recognition of stressed cells Reviewed

    Takanori Sasaki, Takayuki Kanaseki, Yosuke Shionoya, Serina Tokita, Sho Miyamoto, Eri Saka, Vitaly Kochin, Akira Takasawa, Yoshihiko Hirohashi, Yasuaki Tamura, Akihiro Miyazaki, Toshihiko Torigoe, Hiroyoshi Hiratsuka, Noriyuki Sato

    EUROPEAN JOURNAL OF IMMUNOLOGY   46 ( 4 )   929 - 940   2016.4

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    Language：English   Publishing type：Research paper (scientific journal)  

    DOI： 10.1002/eji.201545835

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  • Macroscopic and microscopic features of the mandibular condyle in autopsied elderly individuals Reviewed

    Mitsuyoshi Nakai, Masato Abe, Akihiro Miyazaki, Mineko Fujimiya, Hiroyoshi Hiratsuka

    CLINICAL ANATOMY   27 ( 3 )   399 - 407   2014.4

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    Language：English   Publishing type：Research paper (scientific journal)  

    DOI： 10.1002/ca.22102

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  • Six-transmembrane epithelial antigen of the prostate-1 plays a role for in vivo tumor growth via intercellular communication Reviewed

    Takashi Yamamoto, Yasuaki Tamura, Jun-ichi Kobayashi, Kenjirou Kamiguchi, Yoshihiko Hirohashi, Akihiro Miyazaki, Toshihiko Torigoe, Hiroko Asanuma, Hiroyoshi Hiratsuka, Noriyuki Sato

    EXPERIMENTAL CELL RESEARCH   319 ( 17 )   2617 - 2626   2013.10

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    Language：English   Publishing type：Research paper (scientific journal)  

    DOI： 10.1016/j.yexcr.2013.07.025

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  • Small proline-rich protein-1B is overexpressed in human oral squamous cell cancer stem-like cells and is related to their growth through activation of MAP kinase signal Reviewed

    Yoshitaka Michifuri, Yoshihiko Hirohashi, Toshihiko Torigoe, Akihiro Miyazaki, Jyunki Fujino, Yasuaki Tamura, Tomohide Tsukahara, Takayuki Kanaseki, Junichi Kobayashi, Takanori Sasaki, Akari Takahashi, Kenji Nakamori, Akira Yamaguchi, Hiroyoshi Hiratsuka, Noriyuki Sato

    BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS   439 ( 1 )   96 - 102   2013.9

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    Language：English   Publishing type：Research paper (scientific journal)  

    DOI： 10.1016/j.bbrc.2013.08.021

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  • Silencing of GLUT-1 inhibits sensitization of oral cancer cells to cisplatin during hypoxia Reviewed

    Makoto Shimanishi, Kazuhiro Ogi, Yohei Sogabe, Takeshi Kaneko, Hironari Dehari, Akihiro Miyazaki, Hiroyoshi Hiratsuka

    JOURNAL OF ORAL PATHOLOGY & MEDICINE   42 ( 5 )   382 - 388   2013.5

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    Language：English   Publishing type：Research paper (scientific journal)  

    DOI： 10.1111/jop.12028

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  • General Rules for Clinical and Pathological Studies on Oral Cancer: A Synopsis Reviewed

    Toshiyuki Izumo, Tadaaki Kirita, Eiichiro Ariji, Satoru Ozeki, Norihiko Okada, Sadao Okabe, Yuichiro Okazaki, Ken Omura, Mikio Kusama, Toru Sato, Masanori Shinohara, Kazuo Shimozato

    JAPANESE JOURNAL OF CLINICAL ONCOLOGY   42 ( 11 )   1099 - 1109   2012.11

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    Language：English   Publishing type：Research paper (scientific journal)  

    DOI： 10.1093/jjco/hys141

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  • High expression of ALDH1 and SOX2 diffuse staining pattern of oral squamous cell carcinomas correlates to lymph node metastasis Reviewed

    Yoshitaka Michifuri, Yoshihiko Hirohashi, Toshihiko Torigoe, Akihiro Miyazaki, Junichi Kobayashi, Takanori Sasaki, Jyunki Fujino, Hiroko Asanuma, Yasuaki Tamura, Kenji Nakamori, Tadashi Hasegawa, Hiroyoshi Hiratsuka, Noriyuki Sato

    PATHOLOGY INTERNATIONAL   62 ( 10 )   684 - 689   2012.10

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    Language：English   Publishing type：Research paper (scientific journal)  

    DOI： 10.1111/j.1440-1827.2012.02851.x

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MISC

  • Clinical study of squamous cell carcinoma of the buccal mucosa ; A review of 38 cases treated primarily by surgery.

    Akihiro MIYAZAKI, Makoto NOGUCHI, Hiromi KUBOTA, Yukie KIDO, Takashi IDE, Hiroaki KONDO, Kanako TAKEMURA, Itaru NAGAI, Hisanori KINJYO, Gen-iku KOHAMA

    pn.J.Oral Maxillofac.Surg.   49 ( 9 )   527 - 532   2003

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    Language：Japanese   Publisher：Japanese Society of Oral and Maxillofacial Surgeons  

    Thirty-eight patients with squamous cell carcinoma of the buccal mucosa were treated by surgery at our clinic during the 22-year period from April 1976 through March 1999. The average age of the patients was 61.1 years. The distribution of clinical stage according to the TNM (1997) classification was as follows: stage I, 5 patients; stage II, 12; stage III, 8; and stage N, 13. Thirty-one patients received preoperative chemotherapy consisting of bleomycin alone or in combination with other agents such as cisplatin, methotrexate, or 5-f luorouracil; 5 received preoperative chemoradiotherapy. Response of the primary lesion was evaluated as complete response in 5 patients and partial response in 11. All patients underwent surgical resection. Local and partial excisions were performed via the oral route in 18 patients, through and through excision in 5, and composite operation in 15. Neck lymph node metastasis was histologically confirmed in 12 patients at primary operation and secondary metastasis was confirmed in 2. Primary closure of the surgical defect was done in 10 patients. A local mucosal flap was used in 5 patients, an artifical mucous membrane such as TERUDERMIS® in 14, and a skin graft in 3. Distant flap reconstruction was required in only 6 patients. The local control rate for all patients after initial treatment was 78.9%. Five-year cumulative survival rates calculated by Kaplan-Meier's method were 76.5% for all patients, 100% for those with stage I or III disease, 72.9% for those with stage II disease, and 51.9% for those with stage IVA disease.

    Other Link:： http://search.jamas.or.jp/link/ui/2004048987

    DOI： 10.5794/jjoms.49.527

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  • Antigenic Peptides from Squamous Cell Carcinoma Recognized by Autologous HLA-DR8-restricted CD4+ T Cells.

    Jpn. J. Cancer Res.   93   917 - 924   2002

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  • Control of cell proliferation kinetics of tumor in neoadjuvant chemotherapy for advanced oral squamous cell carcinoma and its prognostic implications

    Makoto Noguchi, Hisanori Kinjyo, Akihiro Miyazaki, Hiromi Kubota, Geniku Kohama

    International Journal of Clinical Oncology   7 ( 3 )   138 - 144   2002

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  • Effects on preoperative therapy for squamous cell carcinoma of the lower alveolus and gingiva

    Hiromi Kubota, Makoto Noguchi, Akihiro Miyazaki, Yukie Kido, Hisanori Kinjyo, Tatsuru Suyama, Toshiaki Nakano, Geniku Kohama

    J. Jpn. Soc. Oral Tumor   13 ( 3 )   81 - 88   2001

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  • Application and therapeutic result of excisional biopsy for early tongue carcinoma

    J. Jpn. Soc. Oral Tumor   13   267 - 270   2001

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Research Projects

  • 口腔腫瘍

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    Grant type：Competitive

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