2025/08/22 更新

写真a

ミヤザキ　アキヒロ
宮﨑　晃亘
所属
医学部 口腔外科学講座 教授
職名
教授
外部リンク

学位

  • 博士（医学）

研究キーワード

  • 口腔外科学

学歴

  • 北海道大学

    - 1991年

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  • 北海道大学

    - 1991年

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    国名： 日本国

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所属学協会

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論文

  • Quantitative Evaluation of Cephalometric Radiographs of Patients With Hemifacial Microsomia. 査読

    Tokura TA, Miyazaki A, Igarashi T, Dehari H, Kobayashi JI, Miki Y, Ogi K, Sonoda T, Yotsuyanagi T, Hiratsuka H

    The Cleft palate-craniofacial journal : official publication of the American Cleft Palate-Craniofacial Association   56 ( 6 )   711 - 719   2019年7月

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  • Selective Neck Dissection and Survival in Pathologically Node-Positive Oral Squamous Cell Carcinoma. 査読

    Shimura S, Ogi K, Miyazaki A, Shimizu S, Kaneko T, Sonoda T, Kobayashi J, Igarashi T, Miyakawa A, Hasegawa T, Hiratsuka H

    Cancers   11 ( 2 )   269 - 269   2019年2月

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    掲載種別：研究論文（学術雑誌）  

    DOI： 10.3390/cancers11020269

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  • Tumor-infiltrating CD8<sup>+</sup> T-cell density is an independent prognostic marker for oral squamous cell carcinoma. 査読

    Shimizu S, Hiratsuka H, Koike K, Tsuchihashi K, Sonoda T, Ogi K, Miyakawa A, Kobayashi J, Kaneko T, Igarashi T, Hasegawa T, Miyazaki A

    Cancer medicine   8 ( 1 )   80 - 93   2019年1月

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    掲載種別：研究論文（学術雑誌）  

    DOI： 10.1002/cam4.1889

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  • Uncommon presentation of desmoplastic fibroblastoma on the tongue of a female patient. 査読

    Tokura T, Kobayashi JI, Okamoto JY, Miyazaki A

    BMJ case reports   2018   2018年10月

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  • Screening for long noncoding RNAs associated with oral squamous cell carcinoma reveals the potentially oncogenic actions of DLEU1. 査読 国際誌

    Koyo Nishiyama, Reo Maruyama, Takeshi Niinuma, Masahiro Kai, Hiroshi Kitajima, Mutsumi Toyota, Yui Hatanaka, Tomohiro Igarashi, Jun-Ichi Kobayashi, Kazuhiro Ogi, Hironari Dehari, Akihiro Miyazaki, Akira Yorozu, Eiichiro Yamamoto, Masashi Idogawa, Yasushi Sasaki, Tamotsu Sugai, Takashi Tokino, Hiroyoshi Hiratsuka, Hiromu Suzuki

    Cell death & disease   9 ( 8 )   826 - 826   2018年8月

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    記述言語：英語   掲載種別：研究論文（学術雑誌）  

    Recent studies have shown that long noncoding RNAs (lncRNAs) have pivotal roles in human malignancies, although their significance in oral squamous cell carcinoma (OSCC) is not fully understood. In the present study, we identified lncRNAs functionally associated with OSCC. By analyzing RNA-seq datasets obtained from primary head and neck squamous cell carcinoma (HNSCC), we identified 15 lncRNAs aberrantly expressed in cancer tissues. We then validated their expression in 18 OSCC cell lines using qRT-PCR and identified 6 lncRNAs frequently overexpressed in OSCC. Among those, we found that knocking down DLEU1 (deleted in lymphocytic leukemia 1) strongly suppressed OSCC cell proliferation. DLEU1 knockdown also suppressed migration, invasion, and xenograft formation by OSCC cells, which is suggestive of its oncogenic functionality. Microarray analysis revealed that DLEU1 knockdown significantly affects expression of a number of cancer-related genes in OSCC cells, including HAS3, CD44, and TP63, suggesting that DLEU1 regulates HA-CD44 signaling. Expression of DLEU1 was elevated in 71% of primary OSCC tissues, and high DLEU1 expression was associated with shorter overall survival of HNSCC patients. These data suggest that elevated DLEU1 expression contributes to OSCC development, and that DLEU1 may be a useful therapeutic target in OSCC.

    DOI： 10.1038/s41419-018-0893-2

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  • Diverticulum of the buccal mucosa: A rare case report and review of the literature 査読

    Akihiro Miyazaki, Sho Miyamoto, Hiromi Nakai, Koyo Nishiyama, Kei Tsuchihashi, Jun-ichi Kobayashi, Kazuhiro Ogi, Hironari Dehari, Tadashi Hasegawa, Hiroyoshi Hiratsuka

    BMC Oral Health   18 ( 1 )   102   2018年6月

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    記述言語：英語   掲載種別：研究論文（学術雑誌）   出版者・発行元：BioMed Central Ltd.  

    DOI： 10.1186/s12903-018-0572-9

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  • LpMab-23-recognizing cancer-type podoplanin is a novel predictor for a poor prognosis of early stage tongue cancer 査読

    Akihiro Miyazaki, Hiromi Nakai, Tomoko Sonoda, Yoshihiko Hirohashi, Mika K. Kaneko, Yukinari Kato, Yoshihiko Sawa, Hiroyoshi Hiratsuka

    Oncotarget   9 ( 30 )   21156 - 21165   2018年4月

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    記述言語：英語   掲載種別：研究論文（学術雑誌）   出版者・発行元：Impact Journals LLC  

    DOI： 10.18632/oncotarget.24986

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  • Tumor budding is an independent prognostic marker in early stage oral squamous cell carcinoma: With special reference to the mode of invasion and worst pattern of invasion 査読

    Shota Shimizu, Akihiro Miyazaki, Tomoko Sonoda, Kazushige Koike, Kazuhiro Ogi, Jun-ichi Kobayashi, Takeshi Kaneko, Tomohiro Igarashi, Megumi Ueda, Hironari Dehari, Akira Miyakawa, Tadashi Hasegawa, Hiroyoshi Hiratsuka

    PLoS ONE   13 ( 4 )   e0195451   2018年4月

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    記述言語：英語   掲載種別：研究論文（学術雑誌）   出版者・発行元：Public Library of Science  

    DOI： 10.1371/journal.pone.0195451

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  • The antigen ASB4 on cancer stem cells serves as a target for CTL immunotherapy of colorectal cancer 査読

    Sho Miyamoto, Vitaly Kochin, Takayuki Kanaseki, Ayumi Hongo, Serina Tokita, Yasuhiro Kikuchi, Akari Takaya, Yoshihiko Hirohashi, Tomohide Tsukahara, Takeshi Terui, Kunihiko Ishitani, Fumitake Hata, Ichiro Takemasa, Akihiro Miyazaki, Hiroyoshi Hiratsuka, Noriyuki Sato, Toshihiko Torigoe

    Cancer Immunology Research   6 ( 3 )   358 - 369   2018年3月

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    記述言語：英語   掲載種別：研究論文（学術雑誌）   出版者・発行元：American Association for Cancer Research Inc.  

    DOI： 10.1158/2326-6066.CIR-17-0518

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  • Additive effect of radiosensitization by 2-deoxy-D-glucose delays DNA repair kinetics and suppresses cell proliferation in oral squamous cell carcinoma 査読

    Mayumi Kawata, Kazuhiro Ogi, Koyo Nishiyama, Sho Miyamoto, Takafumi Nakagaki, Makoto Shimanishi, Akihiro Miyazaki, Hiroyoshi Hiratsuka

    JOURNAL OF ORAL PATHOLOGY & MEDICINE   46 ( 10 )   979 - 985   2017年11月

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    記述言語：英語   掲載種別：研究論文（学術雑誌）  

    DOI： 10.1111/jop.12606

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  • Induction and Analysis of Cytotoxic T-Lymphocytes that Recognize Autologous Oral Squamous Cell Carcinoma 査読

    Jun-Ya Okamoto, Akihiro Miyazaki, Jun-Ichi Kobayashi, Sho Miyamoto, Takanori Sasaki, Takayuki Kanaseki, Yoshihiko Hirohashi, Toshihiko Torigoe, Hiroyoshi Hiratsuka

    ANTICANCER RESEARCH   37 ( 9 )   4889 - 4897   2017年9月

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    記述言語：英語   掲載種別：研究論文（学術雑誌）  

    DOI： 10.21873/anticanres.11898

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  • Relationship between mandibular ramus height and masticatory muscle function in patients with unilateral hemifacial microsomia 査読

    Naohiro Suzuki, Akihiro Miyazaki, Tomohiro Igarashi, Hironari Dehari, Jun-Ichi Kobayashi, Yoshiki Miki, Kazuhiro Ogi, Itaru Nagai, Tomoko Sonoda, Takatoshi Yotsuyanagi, Hiroyoshi Hiratsuka

    Cleft Palate-Craniofacial Journal   54 ( 1 )   43 - 52   2017年1月

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    記述言語：英語   掲載種別：研究論文（学術雑誌）   出版者・発行元：American Cleft Palate Craniofacial Association  

    DOI： 10.1597/14-329

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  • Hypoxia-induced epithelial-mesenchymal transition is regulated by phosphorylation of GSK3-β via PI3 K/Akt signaling in oral squamous cell carcinoma. 査読

    Kaneko T, Dehari H, Sasaki T, Igarashi T, Ogi K, Okamoto JY, Kawata M, Kobayashi JI, Miyazaki A, Nakamori K, Hiratsuka H

    Oral surgery, oral medicine, oral pathology and oral radiology   122 ( 6 )   719 - 730   2016年12月

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    記述言語：英語   掲載種別：研究論文（学術雑誌）  

    DOI： 10.1016/j.oooo.2016.06.008

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  • Microenvironmental stresses induce HLA-E/Qa-1 surface expression and thereby reduce CD8(+) T-cell recognition of stressed cells 査読

    Takanori Sasaki, Takayuki Kanaseki, Yosuke Shionoya, Serina Tokita, Sho Miyamoto, Eri Saka, Vitaly Kochin, Akira Takasawa, Yoshihiko Hirohashi, Yasuaki Tamura, Akihiro Miyazaki, Toshihiko Torigoe, Hiroyoshi Hiratsuka, Noriyuki Sato

    EUROPEAN JOURNAL OF IMMUNOLOGY   46 ( 4 )   929 - 940   2016年4月

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    記述言語：英語   掲載種別：研究論文（学術雑誌）  

    DOI： 10.1002/eji.201545835

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  • Macroscopic and microscopic features of the mandibular condyle in autopsied elderly individuals 査読

    Mitsuyoshi Nakai, Masato Abe, Akihiro Miyazaki, Mineko Fujimiya, Hiroyoshi Hiratsuka

    CLINICAL ANATOMY   27 ( 3 )   399 - 407   2014年4月

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    記述言語：英語   掲載種別：研究論文（学術雑誌）  

    DOI： 10.1002/ca.22102

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  • Six-transmembrane epithelial antigen of the prostate-1 plays a role for in vivo tumor growth via intercellular communication 査読

    Takashi Yamamoto, Yasuaki Tamura, Jun-ichi Kobayashi, Kenjirou Kamiguchi, Yoshihiko Hirohashi, Akihiro Miyazaki, Toshihiko Torigoe, Hiroko Asanuma, Hiroyoshi Hiratsuka, Noriyuki Sato

    EXPERIMENTAL CELL RESEARCH   319 ( 17 )   2617 - 2626   2013年10月

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    記述言語：英語   掲載種別：研究論文（学術雑誌）  

    DOI： 10.1016/j.yexcr.2013.07.025

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  • Small proline-rich protein-1B is overexpressed in human oral squamous cell cancer stem-like cells and is related to their growth through activation of MAP kinase signal 査読

    Yoshitaka Michifuri, Yoshihiko Hirohashi, Toshihiko Torigoe, Akihiro Miyazaki, Jyunki Fujino, Yasuaki Tamura, Tomohide Tsukahara, Takayuki Kanaseki, Junichi Kobayashi, Takanori Sasaki, Akari Takahashi, Kenji Nakamori, Akira Yamaguchi, Hiroyoshi Hiratsuka, Noriyuki Sato

    BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS   439 ( 1 )   96 - 102   2013年9月

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    記述言語：英語   掲載種別：研究論文（学術雑誌）  

    DOI： 10.1016/j.bbrc.2013.08.021

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  • Silencing of GLUT-1 inhibits sensitization of oral cancer cells to cisplatin during hypoxia 査読

    Makoto Shimanishi, Kazuhiro Ogi, Yohei Sogabe, Takeshi Kaneko, Hironari Dehari, Akihiro Miyazaki, Hiroyoshi Hiratsuka

    JOURNAL OF ORAL PATHOLOGY & MEDICINE   42 ( 5 )   382 - 388   2013年5月

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    記述言語：英語   掲載種別：研究論文（学術雑誌）  

    DOI： 10.1111/jop.12028

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  • General Rules for Clinical and Pathological Studies on Oral Cancer: A Synopsis 査読

    Toshiyuki Izumo, Tadaaki Kirita, Eiichiro Ariji, Satoru Ozeki, Norihiko Okada, Sadao Okabe, Yuichiro Okazaki, Ken Omura, Mikio Kusama, Toru Sato, Masanori Shinohara, Kazuo Shimozato

    JAPANESE JOURNAL OF CLINICAL ONCOLOGY   42 ( 11 )   1099 - 1109   2012年11月

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    記述言語：英語   掲載種別：研究論文（学術雑誌）  

    DOI： 10.1093/jjco/hys141

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  • High expression of ALDH1 and SOX2 diffuse staining pattern of oral squamous cell carcinomas correlates to lymph node metastasis 査読

    Yoshitaka Michifuri, Yoshihiko Hirohashi, Toshihiko Torigoe, Akihiro Miyazaki, Junichi Kobayashi, Takanori Sasaki, Jyunki Fujino, Hiroko Asanuma, Yasuaki Tamura, Kenji Nakamori, Tadashi Hasegawa, Hiroyoshi Hiratsuka, Noriyuki Sato

    PATHOLOGY INTERNATIONAL   62 ( 10 )   684 - 689   2012年10月

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    記述言語：英語   掲載種別：研究論文（学術雑誌）  

    DOI： 10.1111/j.1440-1827.2012.02851.x

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MISC

  • 外科療法を主体に治療した頬粘膜扁平上皮癌38例の臨床的検討

    宮崎 晃亘, 野口 誠, 久保田 裕美, 木戸 幸恵, 井手 隆, 近藤 裕亮, 竹村 佳奈子, 永井 格, 金城 尚典, 小浜 源郁

    日本口腔外科学会雑誌   49 ( 9 )   527 - 532   2003年

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    記述言語：日本語   出版者・発行元：Japanese Society of Oral and Maxillofacial Surgeons  

    Thirty-eight patients with squamous cell carcinoma of the buccal mucosa were treated by surgery at our clinic during the 22-year period from April 1976 through March 1999. The average age of the patients was 61.1 years. The distribution of clinical stage according to the TNM (1997) classification was as follows: stage I, 5 patients; stage II, 12; stage III, 8; and stage N, 13. Thirty-one patients received preoperative chemotherapy consisting of bleomycin alone or in combination with other agents such as cisplatin, methotrexate, or 5-f luorouracil; 5 received preoperative chemoradiotherapy. Response of the primary lesion was evaluated as complete response in 5 patients and partial response in 11. All patients underwent surgical resection. Local and partial excisions were performed via the oral route in 18 patients, through and through excision in 5, and composite operation in 15. Neck lymph node metastasis was histologically confirmed in 12 patients at primary operation and secondary metastasis was confirmed in 2. Primary closure of the surgical defect was done in 10 patients. A local mucosal flap was used in 5 patients, an artifical mucous membrane such as TERUDERMIS® in 14, and a skin graft in 3. Distant flap reconstruction was required in only 6 patients. The local control rate for all patients after initial treatment was 78.9%. Five-year cumulative survival rates calculated by Kaplan-Meier's method were 76.5% for all patients, 100% for those with stage I or III disease, 72.9% for those with stage II disease, and 51.9% for those with stage IVA disease.

    その他リンク:： http://search.jamas.or.jp/link/ui/2004048987

    DOI： 10.5794/jjoms.49.527

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  • Antigenic Peptides from Squamous Cell Carcinoma Recognized by Autologous HLA-DR8-restricted CD4+ T Cells.

    Jpn. J. Cancer Res.   93   917 - 924   2002年

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  • Control of cell proliferation kinetics of tumor in neoadjuvant chemotherapy for advanced oral squamous cell carcinoma and its prognostic implications

    Makoto Noguchi, Hisanori Kinjyo, Akihiro Miyazaki, Hiromi Kubota, Geniku Kohama

    International Journal of Clinical Oncology   7 ( 3 )   138 - 144   2002年

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    記述言語：英語  

    DOI： 10.1007/s101470200020

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  • Effects on preoperative therapy for squamous cell carcinoma of the lower alveolus and gingiva

    Hiromi Kubota, Makoto Noguchi, Akihiro Miyazaki, Yukie Kido, Hisanori Kinjyo, Tatsuru Suyama, Toshiaki Nakano, Geniku Kohama

    J. Jpn. Soc. Oral Tumor   13 ( 3 )   81 - 88   2001年

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  • Application and therapeutic result of excisional biopsy for early tongue carcinoma

    J. Jpn. Soc. Oral Tumor   13   267 - 270   2001年

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共同研究・競争的資金等の研究課題

  • 口腔腫瘍

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    資金種別：競争的資金

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