Degree 【 display / non-display 】

Degree 【 display / non-display 】

• 名古屋大学   博士（医学）

Research Experience 【 display / non-display 】

Research Experience 【 display / non-display 】

• 2005.10

  -

  2007.03

  Sapporo Medical University   School of Medicine   助教授

  助教授

• 1998.07

  -

  2005.09

  The University of Tokyo   Graduate School of Medicine   助手

  助手

• 1994.04

  -

  1998.06

  Institute for Developmental Research, Aichi Human Service Center   研究員

  研究員

Professional Memberships 【 display / non-display 】

Professional Memberships 【 display / non-display 】

• 　

  　

  　

  THE MOLECULAR BIOLOGY SOCIETY OF JAPAN

• 　

  　

  　

  THE JAPAN NEUROSCIENCE SOCIETY

• 　

  　

  　

  JAPANESE SOCIETY OF DEVELOPMENTAL BIOLOGISTS

• 　

  　

  　

  Society for Neuroscience

Research Areas 【 display / non-display 】

Research Areas 【 display / non-display 】

• Life sciences   Anatomy  

• Life sciences   Medical biochemistry  

• Life sciences   Functional biochemistry  

• Life sciences   Neuroanatomy and physiology  

• Life sciences   Pathobiochemistry  

Research Interests 【 display / non-display 】

Research Interests 【 display / non-display 】

• 脂質メディエーター

• 嗅覚

• 成長円錐

• Pdnマウス

• semaphorin

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Papers 【 display / non-display 】

Papers 【 display / non-display 】

• Protein Tyrosine Phosphatase delta Mediates the Sema3A-Induced Cortical Basal Dendritic Arborization through the Activation of Fyn Tyrosine Kinase

  Fumio Nakamura, Takako Okada, Maria Shishikura, Noriko Uetani, Masahiko Taniguchi, Takeshi Yagi, Yoichiro Iwakura, Toshio Ohshima, Yoshio Goshima, Stephen M. Strittmatter

  JOURNAL OF NEUROSCIENCE ( SOC NEUROSCIENCE )  37 ( 30 ) 7125 - 7139  2017.07  [Refereed]

  　View Summary

  Leukocyte common antigen-related (LAR) class protein tyrosine phosphatases (PTPs) are critical for axonal guidance; however, their relation to specific guidance cues is poorly defined. We here show that PTP-3, a LAR homolog in Caenorhabditis elegans, is involved in axon guidance regulated by Semaphorin-2A-signaling. PTP delta, one of the vertebrate LAR class PTPs, participates in the Semaphorin-3A (Sema3A)-induced growth cone collapse response of primary cultured dorsal root ganglion neurons from Mus musculus embryos. In vivo, however, the contribution of PTP delta in Sema3A-regualted axon guidance was minimal. Instead, PTP delta played a major role in Sema3A-dependent cortical dendritic growth. Ptp delta(-/-) and Sema3a(-/-) mutant mice exhibited poor arborization of basal dendrites of cortical layer V neurons. This phenotype was observed in both male and female mutants. The double-heterozygous mutants, Ptp delta(+/-); Sema3a(+/-), also showed a similar phenotype, indicating the genetic interaction. In Ptp delta(-/-) brains, Fyn and Src kinases were hyperphosphorylated at their C-terminal Tyr527 residues. Sema3A-stimulation induced dephosphorylation of Tyr527 in the dendrites of wild-type cortical neurons but not of Ptp delta(-/-) Arborization of cortical basal dendrites was reduced in Fyn(-/-) as well as in Ptp delta(+/-); Fyn(+/-) double-heterozygous mutants. Collectively, PTP? mediates Sema3A-signaling through the activation of Fyn by C-terminal dephosphorylation.

  DOI PubMed

• Contribution of semaphorins to the formation of the peripheral nervous system in higher vertebrates

  Tomoyuki Masuda, Masahiko Taniguchi

  CELL ADHESION & MIGRATION ( TAYLOR & FRANCIS INC )  10 ( 6 ) 593 - 603  2016  [Refereed]

  　View Summary

  Semaphorins are a large family of proteins characterized by sema domains and play a key role not only in the formation of neural circuits, but in the immune system, angiogenesis, tumor progression, and bone metabolism. To date, 15 semaphorins have been reported to be involved in the formation of the peripheral nervous system (PNS) in higher vertebrates. A number of experiments have revealed their functions in the PNS, where they act mainly as axonal guidance cues (as repellents or attractants). Semaphorins also play an important role in the migration of neurons and formation of sensory-motor connections in the PNS. This review summarizes recent knowledge regarding the functions of higher vertebrate semaphorins in the formation of the PNS.

  DOI PubMed

• Foreword: Special focus issue on semaphorins

  Masahiko Taniguchi

  CELL ADHESION & MIGRATION ( TAYLOR & FRANCIS INC )  10 ( 6 ) 591 - 592  2016  [Refereed]

  DOI PubMed

• Congenital diseases and semaphorin signaling: Overview to date of the evidence linking them

  Tomoyuki Masuda, Masahiko Taniguchi

  CONGENITAL ANOMALIES ( WILEY-BLACKWELL )  55 ( 1 ) 26 - 30  2015.02  [Refereed]

  　View Summary

  Semaphorins and their receptors, neuropilins and plexins, were initially characterized as a modulator of axonal guidance during development, but are now recognized as a regulator of a wide range of developmental events including morphogenesis and angiogenesis, and activities of the immune system. Owing to the development of next-generation sequencing technologies together with other useful DNA assays, it has also become clear that semaphorin signaling plays a crucial role in many congenital diseases such as retinal degeneration and congenital heart defects. This review summarizes the recent knowledge about the relationship between a variety of congenital diseases and semaphorin signaling.

  DOI PubMed

• Attractive and permissive activities of semaphorin 5A toward dorsal root ganglion axons in higher vertebrate embryos

  Tomoyuki Masuda, Chie Sakuma, Hiroyuki Yaginuma, Masahiko Taniguchi

  CELL ADHESION & MIGRATION ( TAYLOR & FRANCIS INC )  8 ( 6 ) 603 - 606  2014.11  [Refereed]

  　View Summary

  Elongation of the efferent fibers of dorsal root ganglion (DRG) neurons toward their peripheral targets occurs during development. Attractive or permissive systems may be involved in this elongation. However, the molecular mechanisms that control it are largely unknown. Here we show that class 5 semaphorin Sema5A had attractive/permissive effects on DRG axons. In mouse embryos, Sema5A was expressed in and around the path of DRG efferent fibers, and cell aggregates secreting Sema5A attracted DRG axons in vitro. We also found that ectopic Sema5A expression in the spinal cord attracted DRG axons. Together, these findings suggest that Sema5A functions as an attractant to elongate DRG fibers and contributes to the formation of the early sensory network.

  DOI PubMed

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Misc 【 display / non-display 】

Misc 【 display / non-display 】

• Syntaxin 1B-reduction-triggered macropinocytosis mediates Sema3A-induced growth cone collapse

  Hiroyuki Kabayama, Makoto Takeuchi, Masahiko Taniguchi, Naoko Tokushige, Shunji Kozaki, Akihiro Mizutani, Takeshi Nakamura, Katsuhiko Mikoshiba

  NEUROSCIENCE RESEARCH ( ELSEVIER IRELAND LTD )  71   E95 - E95  2011

  Research paper, summary (international conference)  

  DOI

• Analyses of the development of the spinal nerve in the chick embryo

  Tomoyuki Masuda, Chie Sakuma, Masahiko Taniguchi, Hideaki Tanaka, Takashi Shiga, Hiroyuki Yaginuma

  NEUROSCIENCE RESEARCH ( ELSEVIER IRELAND LTD )  68   E247 - E247  2010

  Research paper, summary (international conference)  

  DOI

• Sema3A regulates apical dendritic growth of hippocamal CA1 pyramidal neurons

  Fumio Nakamura, Kozue Ugajin, Naoya Yamashita, Masahiko Taniguchi, Toshio Ohshima, Yoshio Goshima

  NEUROSCIENCE RESEARCH ( ELSEVIER IRELAND LTD )  65   S46 - S46  2009

  Research paper, summary (international conference)  

  DOI

• Ca2+ INDUCES MACROPINOCYTOSIS VIA F-ACTIN DEPOLYMERIZATION DURING GROWTH CONE COLLAPSE

  Hiroyuki Kabayama, Takeshi Nakamura, Makoto Takeuchi, Hirohide Iwasaki, Masahiko Taniguchi, Naoko Tokushige, Katsuhiko Mikoshiba

  JOURNAL OF PHYSIOLOGICAL SCIENCES ( SPRINGER TOKYO )  59   337 - 337  2009

  Research paper, summary (international conference)  

• Morphological analysis of hippocampal CA1 pyramidal neurons in Sema3A (-/-) mutant mice

  Kozue Ugajin, Naoya Yamashita, Masahiko Taniguchi, Fumio Nakamura, Yoshio Goshima

  JOURNAL OF PHARMACOLOGICAL SCIENCES ( JAPANESE PHARMACOLOGICAL SOC )  106   135P - 135P  2008

  Research paper, summary (international conference)  

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Research Projects 【 display / non-display 】

Research Projects 【 display / non-display 】

• 神経回路形成及び高次脳機能におけるセマフォリンの機能解析

  Project Year :

  2016

  -

  2018

   

  谷口 雅彦

  Authorship： Principal investigator

• 免疫系と骨形成における軸索ガイダンス分子の機能解析

  Project Year :

  2015

  -

  2016

   

  谷口 雅彦

  Authorship： Principal investigator

• 神経回路形成におけるセマフォリンの機能

  Project Year :

  2012

  -

  2014

   

  谷口 雅彦

  Authorship： Principal investigator

• The function ofsemaphorin in the formation of neural network

  Grant-in-Aid for Scientific Research (C)

  Project Year :

  2009

  -

  2011

   

  TANIGUCHI Masahiko

  Authorship： Principal investigator

  　View Summary

  During embryogenesis, axons reach their specific targets correctly to form the complex neural network found in the mature functional nervous system. Several groups of axon guidance molecules such as semaphorins, ephrins, netrins, and Slits have been reported to repel or attract growing axons that express their cognate receptors. Herein, I report the cloning and characterization of novel semaphorin genes. These semaphorin genes might repel axons of the specific types during development.

• 中枢神経系の神経回路形成におけるセマフォリンの機能解析

  特定領域研究

  Project Year :

  2006

  -

  2007

   

  谷口 雅彦

  Authorship： Principal investigator

  　View Summary

  複雑な脳神経系において機能的な神経回路を形成するために,回路形成過程を制御する軸索ガイダンス分子が存在する。軸索ガイダンス分子としては,スリット,エフリン,セマフォリン,ネトリンが報告されている。セマフォリンは現在までに20種類以上報告されている大きなファミリー分子で,主に反発因子として機能する。セマフオリンの新たな機能解析の目的で新規セマフォリンのクローニングを試みた。その結果,2種類のマウスセマフォリンのクローニングに成功した。Sema3GとSema6Dである。Sema3Gは脳特異的という発現様式ではないが,脳では小脳特異的に発現している。レセプターはニューロピリン-2だと考えられ,神経軸索に対する反発活性を持つ。生後,顆粒細胞層などに発現してくるので顆粒細胞の移動に関与していると考えている。Sema6Dは脳に高発現している。脳での発現は胎児から生体に至るまで同程度発現している。Sema3GとSema6Dのノックアウトマウスの作成を進めている。また,最近モデル動物としてゼブラフィッシュにも注目して解析している。このため先ずゼブラフィッシュSema6Dのクローニングを試みた。クローニングに成功したが,この課程において,Sema6EとSema6Fのクローニングにも成功した。Sema6EとSema6Fはゼブラフィッシュ特異的なセマフォリンである。Sema6DとSema6Eは神経...

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