Degree 【 display / non-display 】

Degree 【 display / non-display 】

• 名古屋大学   博士（医学）

Research Experience 【 display / non-display 】

Research Experience 【 display / non-display 】

• 2007.04

  -

  Now

  Sapporo Medical University   Research Institute for Frontier Medicine   准教授

  准教授

• 2005.10

  -

  2007.03

  Sapporo Medical University   School of Medicine   助教授

  助教授

• 1998.07

  -

  2005.09

  The University of Tokyo   Graduate School of Medicine   助手

  助手

• 1994.04

  -

  1998.06

  Institute for Developmental Research, Aichi Human Service Center   研究員

  研究員

Professional Memberships 【 display / non-display 】

Professional Memberships 【 display / non-display 】

• 　

  　

  　

  JAPANESE SOCIETY OF DEVELOPMENTAL BIOLOGISTS

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  THE JAPAN NEUROSCIENCE SOCIETY

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  THE MOLECULAR BIOLOGY SOCIETY OF JAPAN

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  Society for Neuroscience

Research Areas 【 display / non-display 】

Research Areas 【 display / non-display 】

• Life sciences   Anatomy  

• Life sciences   Medical biochemistry  

• Life sciences   Functional biochemistry  

• Life sciences   Neuroanatomy and physiology  

• Life sciences   Pathobiochemistry  

Affiliation 【 display / non-display 】

Affiliation 【 display / non-display 】

• Sapporo Medical University   Department of Cell Science, Research Institute for Frontier Medicine, School of Medicine   Associate Professor  

Research Interests 【 display / non-display 】

Research Interests 【 display / non-display 】

• コラプシン

• semaphorin III

• Xtマウス

• Collapsin

• 軸索ガイダンス

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Papers 【 display / non-display 】

Papers 【 display / non-display 】

• Japanese Soy Sauce Improves Upper Limb Performance.

  Yano Y, Murata Y, Taniguchi M, Okutani F, Yamaguchi M, Kaba H

  Occupational Therapy International   2019   ID 2748721  2019  [Refereed]

  DOI PubMed

• α2-Adrenergic receptor activation promotes long-term potentiation at excitatory synapses in the mouse accessory olfactory bulb

  Guang-Zhe Huang, Mutsuo Taniguchi, Ye-Bo Zhou, Jing-Ji Zhang, Fumino Okutani, Yoshihiro Murata, Masahiro Yamaguchi, Hideto Kaba

  Learning and Memory ( Cold Spring Harbor Laboratory Press )  25 ( 4 ) 147 - 157  2018.04  [Refereed]

  　View Summary

  The formation of mate recognition memory in mice is associated with neural changes at the reciprocal dendrodendritic synapses between glutamatergic mitral cell (MC) projection neurons and GABAergic granule cell (GC) interneurons in the accessory olfactory bulb (AOB). Although noradrenaline (NA) plays a critical role in the formation of the memory, the mechanism by which it exerts this effect remains unclear. Here we used extracellular field potential and whole-cell patchclamp recordings to assess the actions of bath-applied NA (10 μM) on the glutamatergic transmission and its plasticity at the MC-to-GC synapse in the AOB. Stimulation (400 stimuli) of MC axons at 10 Hz but not at 100 Hz effectively induced N-methyl-D-aspartate (NMDA) receptor-dependent long-term potentiation (LTP), which exhibited reversibility. NA paired with subthreshold 10-Hz stimulation (200 stimuli) facilitated the induction of NMDA receptor-dependent LTP via the activation of α2-adrenergic receptors (ARs). We next examined how NA, acting at α2-ARs, facilitates LTP induction. In terms of acute actions, NA suppressed GC excitatory postsynaptic current (EPSC) responses to single pulse stimulation of MC axons by reducing glutamate release from MCs via G-protein coupled inhibition of calcium channels. Consequently, NA reduced recurrent inhibition of MCs, resulting in the enhancement of evoked EPSCs and spike fidelity in GCs during the 10-Hz stimulation used to induce LTP. These results suggest that NA, acting at α2-ARs, facilitates the induction of NMDA receptor-dependent LTP at the MC-to-GC synapse by shifting its threshold through disinhibition of MCs.

  DOI PubMed

• Protein Tyrosine Phosphatase delta Mediates the Sema3A-Induced Cortical Basal Dendritic Arborization through the Activation of Fyn Tyrosine Kinase

  Fumio Nakamura, Takako Okada, Maria Shishikura, Noriko Uetani, Masahiko Taniguchi, Takeshi Yagi, Yoichiro Iwakura, Toshio Ohshima, Yoshio Goshima, Stephen M. Strittmatter

  JOURNAL OF NEUROSCIENCE ( SOC NEUROSCIENCE )  37 ( 30 ) 7125 - 7139  2017.07  [Refereed]

  　View Summary

  Leukocyte common antigen-related (LAR) class protein tyrosine phosphatases (PTPs) are critical for axonal guidance; however, their relation to specific guidance cues is poorly defined. We here show that PTP-3, a LAR homolog in Caenorhabditis elegans, is involved in axon guidance regulated by Semaphorin-2A-signaling. PTP delta, one of the vertebrate LAR class PTPs, participates in the Semaphorin-3A (Sema3A)-induced growth cone collapse response of primary cultured dorsal root ganglion neurons from Mus musculus embryos. In vivo, however, the contribution of PTP delta in Sema3A-regualted axon guidance was minimal. Instead, PTP delta played a major role in Sema3A-dependent cortical dendritic growth. Ptp delta(-/-) and Sema3a(-/-) mutant mice exhibited poor arborization of basal dendrites of cortical layer V neurons. This phenotype was observed in both male and female mutants. The double-heterozygous mutants, Ptp delta(+/-); Sema3a(+/-), also showed a similar phenotype, indicating the genetic interaction. In Ptp delta(-/-) brains, Fyn and Src kinases were hyperphosphorylated at their C-terminal Tyr527 residues. Sema3A-stimulation induced dephosphorylation of Tyr527 in the dendrites of wild-type cortical neurons but not of Ptp delta(-/-) Arborization of cortical basal dendrites was reduced in Fyn(-/-) as well as in Ptp delta(+/-); Fyn(+/-) double-heterozygous mutants. Collectively, PTP? mediates Sema3A-signaling through the activation of Fyn by C-terminal dephosphorylation.

  DOI PubMed

• Foreword: Special focus issue on semaphorins

  Masahiko Taniguchi

  CELL ADHESION & MIGRATION ( TAYLOR & FRANCIS INC )  10 ( 6 ) 591 - 592  2016  [Refereed]

  DOI PubMed

• Contribution of semaphorins to the formation of the peripheral nervous system in higher vertebrates

  Tomoyuki Masuda, Masahiko Taniguchi

  CELL ADHESION & MIGRATION ( TAYLOR & FRANCIS INC )  10 ( 6 ) 593 - 603  2016  [Refereed]

  　View Summary

  Semaphorins are a large family of proteins characterized by sema domains and play a key role not only in the formation of neural circuits, but in the immune system, angiogenesis, tumor progression, and bone metabolism. To date, 15 semaphorins have been reported to be involved in the formation of the peripheral nervous system (PNS) in higher vertebrates. A number of experiments have revealed their functions in the PNS, where they act mainly as axonal guidance cues (as repellents or attractants). Semaphorins also play an important role in the migration of neurons and formation of sensory-motor connections in the PNS. This review summarizes recent knowledge regarding the functions of higher vertebrate semaphorins in the formation of the PNS.

  DOI PubMed

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Misc 【 display / non-display 】

Misc 【 display / non-display 】

• Syntaxin 1B-reduction-triggered macropinocytosis mediates Sema3A-induced growth cone collapse

  Hiroyuki Kabayama, Makoto Takeuchi, Masahiko Taniguchi, Naoko Tokushige, Shunji Kozaki, Akihiro Mizutani, Takeshi Nakamura, Katsuhiko Mikoshiba

  NEUROSCIENCE RESEARCH ( ELSEVIER IRELAND LTD )  71   E95 - E95  2011

  Research paper, summary (international conference)  

  DOI

• Analyses of the development of the spinal nerve in the chick embryo

  Tomoyuki Masuda, Chie Sakuma, Masahiko Taniguchi, Hideaki Tanaka, Takashi Shiga, Hiroyuki Yaginuma

  NEUROSCIENCE RESEARCH ( ELSEVIER IRELAND LTD )  68   E247 - E247  2010

  Research paper, summary (international conference)  

  DOI

• Ca2+ INDUCES MACROPINOCYTOSIS VIA F-ACTIN DEPOLYMERIZATION DURING GROWTH CONE COLLAPSE

  Hiroyuki Kabayama, Takeshi Nakamura, Makoto Takeuchi, Hirohide Iwasaki, Masahiko Taniguchi, Naoko Tokushige, Katsuhiko Mikoshiba

  JOURNAL OF PHYSIOLOGICAL SCIENCES ( SPRINGER TOKYO )  59   337 - 337  2009

  Research paper, summary (international conference)  

• Sema3A regulates apical dendritic growth of hippocamal CA1 pyramidal neurons

  Fumio Nakamura, Kozue Ugajin, Naoya Yamashita, Masahiko Taniguchi, Toshio Ohshima, Yoshio Goshima

  NEUROSCIENCE RESEARCH ( ELSEVIER IRELAND LTD )  65   S46 - S46  2009

  Research paper, summary (international conference)  

  DOI

• Morphological analysis of hippocampal CA1 pyramidal neurons in sema3A (-/-) mice

  Fumio Nakamura, Kozue Ugajin, Naoya Yamashita, Masahiko Taniguchi, Yoshi Goshima

  NEUROSCIENCE RESEARCH ( ELSEVIER IRELAND LTD )  61   S162 - S162  2008

  Research paper, summary (international conference)  

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Research Projects 【 display / non-display 】

Research Projects 【 display / non-display 】

• 神経回路形成及び高次脳機能におけるセマフォリンの機能解析

  Project Year :

  2016

  -

  2018

   

  谷口 雅彦

  Authorship： Principal investigator

• 免疫系と骨形成における軸索ガイダンス分子の機能解析

  Project Year :

  2015

  -

  2016

   

  谷口 雅彦

  Authorship： Principal investigator

• 神経回路形成におけるセマフォリンの機能

  Project Year :

  2012

  -

  2014

   

  谷口 雅彦

  Authorship： Principal investigator

• The function ofsemaphorin in the formation of neural network

  Grant-in-Aid for Scientific Research (C)

  Project Year :

  2009

  -

  2011

   

  TANIGUCHI Masahiko

  Authorship： Principal investigator

  　View Summary

  During embryogenesis, axons reach their specific targets correctly to form the complex neural network found in the mature functional nervous system. Several groups of axon guidance molecules such as semaphorins, ephrins, netrins, and Slits have been reported to repel or attract growing axons that express their cognate receptors. Herein, I report the cloning and characterization of novel semaphorin genes. These semaphorin genes might repel axons of the specific types during development.

• 中枢神経系の神経回路形成におけるセマフォリンの機能解析

  特定領域研究

  Project Year :

  2006

  -

  2007

   

  谷口 雅彦

  Authorship： Principal investigator

  　View Summary

  複雑な脳神経系において機能的な神経回路を形成するために,回路形成過程を制御する軸索ガイダンス分子が存在する。軸索ガイダンス分子としては,スリット,エフリン,セマフォリン,ネトリンが報告されている。セマフォリンは現在までに20種類以上報告されている大きなファミリー分子で,主に反発因子として機能する。セマフオリンの新たな機能解析の目的で新規セマフォリンのクローニングを試みた。その結果,2種類のマウスセマフォリンのクローニングに成功した。Sema3GとSema6Dである。Sema3Gは脳特異的という発現様式ではないが,脳では小脳特異的に発現している。レセプターはニューロピリン-2だと考えられ,神経軸索に対する反発活性を持つ。生後,顆粒細胞層などに発現してくるので顆粒細胞の移動に関与していると考えている。Sema6Dは脳に高発現している。脳での発現は胎児から生体に至るまで同程度発現している。Sema3GとSema6Dのノックアウトマウスの作成を進めている。また,最近モデル動物としてゼブラフィッシュにも注目して解析している。このため先ずゼブラフィッシュSema6Dのクローニングを試みた。クローニングに成功したが,この課程において,Sema6EとSema6Fのクローニングにも成功した。Sema6EとSema6Fはゼブラフィッシュ特異的なセマフォリンである。Sema6DとSema6Eは神経...

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