Updated on 2025/09/28

写真a

 
IYAMA Satoshi
 
Organization
School of Medicine Department of Hematology Assistant Professor
Title
Assistant Professor
Homepage
https://kaken.nii.ac.jp/d/r/50398319.ja.html
External link

Research Interests

  • 悪性リンパ腫

  • 骨髄異形成症候群

  • ゲノム

  • 造血幹細胞移植

  • MDS

  • 検査医学

  • Blood transfusion

  • 白血病

Research Areas

  • Life Science / Hematology and medical oncology

Research History

  • Sapporo Medical University   Department of Hematology   Associate Professor

    2025.7

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  • Sapporo Medical University Hospital   Division of Laboratory Diagnosis

    2022.4

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  • Sapporo Medical University   Lecturer

    2021.2

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  • Sapporo Medical University   School of Medicine   Assistant Professor

    2007 - 2021.2

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Papers

  • Prognostic impact of TET2 mutations in patients with acute myeloid leukemia: HM-SCREEN-Japan 01 and 02 study. International journal

    Satoshi Iyama, SungGi Chi, Masashi Idogawa, Takayuki Ikezoe, Kentaro Fukushima, Yoshikazu Utsu, Junya Kanda, Goichi Yoshimoto, Takahiro Kobayashi, Naoko Hosono, Takahiro Yamauchi, Takeshi Kondo, Yukinori Nakamura, Kensuke Kojima, Chikashi Yoshida, Akihiko Gotoh, Kazuhito Yamamoto, Junya Kuroda, Kenji Ishitsuka, Emiko Sakaida, Hiroto Horiguchi, Kohichi Takada, Hirofumi Ohnishi, Masayoshi Kobune, Yosuke Minami

    Annals of hematology   104 ( 1 )   275 - 284   2025.1

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    Language：English   Publishing type：Research paper (scientific journal)  

    Ten-eleven translocation-2 (TET2) gene mutations are observed in 12-20% of adult patients with acute myeloid leukemia (AML). The prognostic impact of TET2 mutations in patients with AML and myelodysplastic syndromes has been reported in several studies; however, their results remain controversial. Therefore, we aimed to analyze the prevalence and significance of TET2 mutations in patients with AML. Data were obtained from 331 patients with AML according to the Hematologic Malignancies-SCREEN-Japan 01 and 02 studies, which were prospective multicenter genomic profiling analyses. We found a distinct type of TET2 mutations, with a particularly detrimental prognosis in the patients. Thirty-five patients with TET2 'significant' mutations were identified (26 with frameshift mutations and nine with nonsense mutations). The proportion of patients with TET2 mutations was 31.7% (10.6% and 21.1% in the TET2 significant and non-significant mutation groups). The TET2 significant mutation group had a shorter OS than the TET2 non-significant mutation or wild-type TET2 group (median: 15.9 vs. 35.0 vs. 25.9 months). Regarding the response to chemotherapy according to TET2 status, the complete response (CR) or CR with incomplete count recovery rate was 37.1% in the TET2 significant mutation group and 46.6% in the non-significant mutation or wild-type group. Allogeneic hematopoietic stem cell transplantation (allo-HSCT) improved patient prognosis in the TET2 non-significant mutation or wild-type TET2 group; however, allo-HSCT did not affect prognosis in the TET2 significant mutation group. This study indicates that certain TET2 mutations in patients with AML may have detrimental effects.

    DOI： 10.1007/s00277-025-06227-y

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  • FLT3 inhibitors and hematopoietic cell transplantation prolong survival in patients with FLT3-ITD-positive AML. International journal

    Toshihiro Matsukawa, Masahiro Onozawa, Takeshi Kondo, Minoru Kanaya, Daisuke Hidaka, Shuichi Ota, Akio Mori, Akio Shigematsu, Takuto Miyagishima, Yasutaka Kakinoki, Junichi Hashiguchi, Satoshi Yamamoto, Masayo Yamamoto, Kentaro Wakasa, Mutsumi Takahata, Toshimichi Ishihara, Yoshihito Haseyama, Akihito Fujimi, Tetsuya Igarashi, Takehiro Sarashina, Satoshi Iyama, Ryoji Kobayashi, Hajime Sakai, Katsuya Fujimoto, Junki Inamura, Yuji Kanisawa, Shinsuke Hirabayashi, Tomoyuki Endo, Daigo Hashimoto, Takanori Teshima

    Annals of hematology   103 ( 12 )   5333 - 5340   2024.12

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    Language：English   Publishing type：Research paper (scientific journal)  

    Acute myeloid leukemia (AML) is an aggressive hematological malignancy with genetic alterations. The FMS-like tyrosine kinase 3 (FLT3) gene is frequently mutated in adult de novo AML, with two types of mutations: internal tandem duplication (ITD) and point mutations in the tyrosine kinase domain. This study aimed to investigate the impact of FLT3 inhibitors and hematopoietic cell transplantation (HCT) on survival outcomes in patients with FLT3-ITD AML in a real-world setting. We retrospectively analyzed 139 patients with FLT3-ITD-positive AML between 2012 and 2021. The median age was 63 years. In the propensity score-matched cohort, FLT3 inhibitors improved overall survival (OS) compared with patients treated without FLT3 inhibitors (3-year OS: 33.7% vs. 25.8%, p = 0.021). Patients who underwent HCT had superior outcomes to those without HCT (3-year OS: 45.3% vs. 2.2%, p < 0.0001). The combination of FLT3 inhibitors and HCT resulted in the highest OS and relapse-free survival (RFS) rates (3-year OS: 62.4%; 3-year RFS: 44.4%). Disease status before transplantation did not predict the prognosis, but use of FLT3 inhibitors increased survival in patients without complete remission before HCT. These results demonstrate the clinical impact of FLT3 inhibitors on survival outcomes in patients with FLT3-ITD-positive AML, particularly when combined with HCT. FLT3 inhibitors can improve the prognosis of AML with FLT3 mutations, especially in patients who undergo HCT.

    DOI： 10.1007/s00277-024-06125-9

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  • Intravenous Infusion of Autologous Mesenchymal Stem Cells Expanded in Auto Serum for Chronic Spinal Cord Injury Patients: A Case Series. International journal

    Ryosuke Hirota, Masanori Sasaki, Satoshi Iyama, Kota Kurihara, Ryunosuke Fukushi, Hisashi Obara, Tsutomu Oshigiri, Tomonori Morita, Masahito Nakazaki, Takahiro Namioka, Ai Namioka, Rie Onodera, Yuko Kataoka-Sasaki, Shinichi Oka, Mitsuhiro Takemura, Ryo Ukai, Takahiro Yokoyama, Yuichi Sasaki, Tatsuro Yamashita, Masato Kobayashi, Yusuke Okuma, Reiko Kondo, Ryo Aichi, Satoko Ohmatsu, Noritaka Kawashima, Yoichi M Ito, Masayoshi Kobune, Kohichi Takada, Sumio Ishiai, Toru Ogata, Atsushi Teramoto, Toshihiko Yamashita, Jeffery D Kocsis, Osamu Honmou

    Journal of clinical medicine   13 ( 20 )   2024.10

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    Language：English   Publishing type：Research paper (scientific journal)  

    Objective: The safety, feasibility, and potential functional improvement following the intravenous infusion of mesenchymal stem cells (MSCs) were investigated in patients with chronic severe spinal cord injury (SCI). Methods: The intravenous infusion of autologous MSCs cultured in auto-serum under Good Manufacturing Practices (GMP) was administered to seven patients with chronic SCI (ranging from 1.3 years to 27 years after the onset of SCI). In addition to evaluating feasibility and safety, neurological function was evaluated using the American Spinal Injury Association Impairment Scale (AIS), International Standards for Neurological Classification of Spinal Cord Injury (ISCSCI-92), and Spinal Cord Independence Measure III (SCIM-III). Results: No serious adverse events occurred. Neither CNS tumors, abnormal cell growth, nor neurological deterioration occurred in any patients. While this initial case series was not blinded, significant functional improvements and increased quality of life (QOL) were observed at 90 and 180 days post-MSC infusion compared to pre-infusion status. One patient who had an AIS grade C improved to grade D within six months after MSC infusion. Conclusions: This case series suggests that the intravenous infusion of autologous MSCs is a safe and feasible therapeutic approach for chronic SCI patients. Furthermore, our data showed significant functional improvements and better QOL after MSC infusion in patients with chronic SCI. A blind large-scale study will be necessary to fully evaluate this possibility.

    DOI： 10.3390/jcm13206072

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  • Intravenous Infusion of Autologous Mesenchymal Stem Cells Expanded in Auto Serum for Chronic Spinal Cord Injury Patients: A Case Series

    Ryosuke Hirota, Masanori Sasaki, Satoshi Iyama, Kota Kurihara, Ryunosuke Fukushi, Hisashi Obara, Tsutomu Oshigiri, Tomonori Morita, Masahito Nakazaki, Takahiro Namioka, Ai Namioka, Rie Onodera, Yuko Kataoka-Sasaki, Shinichi Oka, Mitsuhiro Takemura, Ryo Ukai, Takahiro Yokoyama, Yuichi Sasaki, Tatsuro Yamashita, Masato Kobayashi, Yusuke Okuma, Reiko Kondo, Ryo Aichi, Satoko Ohmatsu, Noritaka Kawashima, Yoichi M. Ito, Masayoshi Kobune, Kohichi Takada, Sumio Ishiai, Toru Ogata, Atsushi Teramoto, Toshihiko Yamashita, Jeffery D. Kocsis, Osamu Honmou

    Journal of Clinical Medicine   13 ( 20 )   2024.10

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    Publishing type：Research paper (scientific journal)  

    DOI： 10.3390/jcm13206072

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  • Novel method for assessing sinusoidal obstruction syndrome using four‐dimensional computed tomography

    Saori Shimoyama‐Ibuki, Satoshi Iyama, Yoshiya Ohashi, Kento Ono, Yusuke Sugama, Chisa Fujita, Akari Goto, Hiroto Horiguchi, Akihito Fujimi, Takeo Tanaka, Kohichi Takada, Koh‐Ichi Sakata, Masayoshi Kobune

    eJHaem   2024.7

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    Publishing type：Research paper (scientific journal)   Publisher：Wiley  

    Abstract

    Introduction

    To diagnose sinusoidal obstruction syndrome/veno‐occlusive disease (SOS/VOD), transabdominal ultrasonography is usually used to detect hemodynamic changes, but we tried to detect the changes using four‐dimensional computed tomography (4D‐CT). A 42‐year‐old Japanese woman was diagnosed with late‐onset SOS/VOD with transabdominal ultrasonography and was also assessed using 4D‐CT. Method We analyzed the portal vein (PV) contrast effect every 1.5 seconds and plotted the values of the contrast effect. With this graph, we analyzed three hemodynamic parameters.

    Result

    We found that these parameters correlated with the patient's status and indicated stasis due to sinusoid constriction.

    Conclusion

    4D‐CT may become a helpful tool to diagnose and follow up with SOS/VOD.

    DOI： 10.1002/jha2.990

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  • Intravenous infusion of auto-serum-expanded autologous mesenchymal stem cells into chronic severe brain injury patients

    Tomohiro Yamaki, Shinichi Oka, Satoshi Iyama, Masanori Sasaki, Rie Onodera, Yuko Kataoka-Sasaki, Takahiro Namioka, Ai Namioka, Masahito Nakazaki, Mitsuhiro Takemura, Ryo Ukai, Takahiro Yokoyama, Yuichi Sasaki, Tatsuro Yamashita, Masato Kobayashi, Misako Yamaguchi, Marina Fukino, Taro Takazawa, Megumi Hayasaka, Takamitsu Owaku, Mika Funakura, Shinji Onodera, Yoichi M. Ito, Masayoshi Kobune, Junji Kato, Sumio Ishiai, Jeffery D. Kocsis, Masaru Odaki, Yasuo Iwadate, Shigeki Kobayashi, Osamu Honmou

    Interdisciplinary Neurosurgery: Advanced Techniques and Case Management   36   2024.6

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    Publishing type：Research paper (scientific journal)  

    DOI： 10.1016/j.inat.2023.101927

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  • Novel stratification for newly diagnosed acute myeloid leukaemia treated with venetoclax-based therapy in the real world: Hokkaido Leukemia Net Study. International journal

    Naoki Miyashita, Masahiro Onozawa, Toshihiro Matsukawa, Akio Mori, Daisuke Hidaka, Koichiro Minauchi, Akio Shigematsu, Junichi Hashiguchi, Tetsuyuki Igarashi, Yasutaka Kakinoki, Yutaka Tsutsumi, Makoto Ibata, Kentaro Wakasa, Katsuya Fujimoto, Toshimichi Ishihara, Hajime Sakai, Satoshi Iyama, Tatsuo Oyake, Takeshi Kondo, Takanori Teshima

    British journal of haematology   2024.1

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    Language：English   Publishing type：Research paper (scientific journal)  

    DOI： 10.1111/bjh.19292

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  • Anti‐CD38 antibody isatuximab monotherapy for Japanese individuals with relapsed/refractory multiple myeloma: An update of the phase 1/2 ISLANDs study

    Kazutaka Sunami, Shin‐ichi Fuchida, Kenshi Suzuki, Masaki Ri, Morio Matsumoto, Chihiro Shimazaki, Hideki Asaoku, Hirohiko Shibayama, Kenichi Ishizawa, Hiroyuki Takamatsu, Takashi Ikeda, Dai Maruyama, Kazunori Imada, Michihiro Uchiyama, Toru Kiguchi, Satoshi Iyama, Hirokazu Murakami, Reiko Onishi, Keisuke Tada, Shinsuke Iida

    Hematological Oncology   41 ( 3 )   442 - 452   2022.12

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    Publishing type：Research paper (scientific journal)   Publisher：Wiley  

    Abstract

    The primary analysis of the phase 1/2 ISLANDs study in Japanese individuals with relapsed/refractory multiple myeloma (RRMM) showed that isatuximab monotherapy was well tolerated and effective, even in participants with high‐risk cytogenetic abnormalities. Here, we report a prespecified second analysis conducted 20 months after the first dosing of the last participant (ClinicalTrials.gov identifier: NCT02812706). The primary objectives were to evaluate the safety and tolerability of isatuximab in phase 1 and to evaluate the efficacy of isatuximab, including assessment of overall response rate (ORR) at the recommended dose (RD), in phase 2. In phase 1, three participants received isatuximab 10 mg/kg every week (QW) for 4 weeks/cycle followed by every 2 weeks (Q2W) and five participants received 20 mg/kg QW/Q2W. Since no dose‐limiting toxicities occurred in phase 1, 20 mg/kg QW/Q2W was identified as the RD for the phase 2 study (n = 28). At the time of data cut‐off, three participants (one in phase 1 and two in phase 2) continued to receive isatuximab; disease progression and treatment‐related adverse events were the most common reasons for treatment discontinuation. The overall safety profile was consistent with the primary analysis. One death, not related to isatuximab treatment, was reported since the first analysis. The ORR and clinical benefit rate remained unchanged from the primary analysis at 36.4% (95% confidence interval [CI]: 20.4%–54.9%) and 54.5% (95% CI: 36.4%–71.9%), respectively. The median progression‐free survival (PFS) was 5.6 months, longer than the median PFS reported in the primary analysis (4.7 months), whereas median overall survival was not reached. Overall, isatuximab 20 mg/kg QW/Q2W had an acceptable safety and tolerability profile and showed promising antitumor activity in Japanese individuals with RRMM.

    Other Link： https://onlinelibrary.wiley.com/doi/full-xml/10.1002/hon.3105

    DOI： 10.1002/hon.3105

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  • Humanized <scp>anti‐IL</scp> ‐26 monoclonal antibody as a novel targeted therapy for chronic graft‐versus‐host disease

    Ryo Hatano, Takumi Itoh, Haruna Otsuka, Harumi Saeki, Ayako Yamamoto, Dan Song, Yuki Shirakawa, Satoshi Iyama, Tsutomu Sato, Noriaki Iwao, Norihiro Harada, Thomas M. Aune, Nam H. Dang, Yutaro Kaneko, Taketo Yamada, Chikao Morimoto, Kei Ohnuma

    American Journal of Transplantation   2022.8

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    Publishing type：Research paper (scientific journal)   Publisher：Wiley  

    DOI： 10.1111/ajt.17178

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  • 血液疾患患者におけるCOVID-19感染症4例の報告(Four cases of COVID-19 patients with hematological malignancy)

    小野 賢人, 堀口 拓人, 下山 紗央莉, 藤田 千紗, 後藤 亜香利, 池田 博, 井山 諭, 村瀬 和幸, 高田 弘一, 藤谷 好弘, 高橋 聡, 黒沼 幸治, 小船 雅義

    日本血液学会学術集会   83回   OS3 - 4   2021.9

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    Language：English   Publisher：(一社)日本血液学会  

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  • 未分化大細胞リンパ腫の加療中に発症したCOVID-19関連肺炎

    小野 賢人, 堀口 拓人, 下山 紗央莉, 藤田 千紗, 後藤 亜香利, 池田 博, 井山 諭, 藤谷 好弘, 高橋 聡, 黒沼 幸治, 小船 雅義

    臨床血液   62 ( 7 )   852 - 852   2021.7

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    Language：Japanese   Publisher：(一社)日本血液学会-東京事務局  

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  • Six-transmembrane epithelial antigen of the prostate 1 accelerates cell proliferation by targeting c-Myc in liver cancer cells

    Kazutaka Iijima, Hajime Nakamura, Kohichi Takada, Naotaka Hayasaka, Tomohiro Kubo, Yui Umeyama, Satoshi Iyama, Koji Miyanishi, Masayoshi Kobune, Junji Kato

    Oncology Letters   22 ( 1 )   2021.5

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    Publishing type：Research paper (scientific journal)   Publisher：Spandidos Publications  

    DOI： 10.3892/ol.2021.12807

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  • Intravenous infusion of auto serum-expanded autologous mesenchymal stem cells in spinal cord injury patients: 13 case series. International journal

    Osamu Honmou, Toshihiko Yamashita, Tomonori Morita, Tsutomu Oshigiri, Ryosuke Hirota, Satoshi Iyama, Junji Kato, Yuichi Sasaki, Sumio Ishiai, Yoichi M Ito, Ai Namioka, Takahiro Namioka, Masahito Nakazaki, Yuko Kataoka-Sasaki, Rie Onodera, Shinichi Oka, Masanori Sasaki, Stephen G Waxman, Jeffery D Kocsis

    Clinical neurology and neurosurgery   203   106565 - 106565   2021.4

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    Language：English   Publishing type：Research paper (scientific journal)  

    BACKGROUND: Although spinal cord injury (SCI) is a major cause of disability, current therapeutic options remain limited. Recent progress in cellular therapy with mesenchymal stem cells (MSCs) has provided improved function in animal models of SCI. We investigated the safety and feasibility of intravenous infusion of MSCs for SCI patients and assessed functional status after MSC infusion. METHODS: In this phase 2 study of intravenous infusion of autologous MSCs cultured in auto-serum, a single infusion of MSCs under Good Manufacturing Practice (GMP) production was delivered in 13 SCI patients. In addition to assessing feasibility and safety, neurological function was assessed using the American Spinal Injury Association Impairment Scale (ASIA), International Standards for Neurological and Functional Classification of Spinal Cord (ISCSCI-92). Ability of daily living was assessed using Spinal Cord Independence Measure (SCIM-III). The study protocol was based on advice provided by the Pharmaceuticals and Medical Devices Agency in Japan. The trial was registered with the Japan Medical Association (JMA-IIA00154). RESULTS: No serious adverse events were associated with MSC injection. There was neurologic improvement based on ASIA grade in 12 of the 13 patients at six months post-MSC infusion. Five of six patients classified as ASIA A prior to MSC infusion improved to ASIA B (3/6) or ASIA C (2/6), two ASIA B patients improved to ASIA C (1/2) or ASIA D (1/2), five ASIA C patients improved and reached a functional status of ASIA D (5/5). Notably, improvement from ASIA C to ASIA D was observed one day following MSC infusion for all five patients. Assessment of both ISCSCI-92, SCIM-III also demonstrated functional improvements at six months after MSC infusion, compared to the scores prior to MSC infusion in all patients. CONCLUSION: While we emphasize that this study was unblinded, and does not exclude placebo effects or a contribution of endogenous recovery or observer bias, our observations provide evidence supporting the feasibility, safety and functional improvements of infused MSCs into patients with SCI.

    DOI： 10.1016/j.clineuro.2021.106565

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  • Possible clinical outcomes using early enteral nutrition in individuals with allogeneic hematopoietic stem cell transplantation: A single-center retrospective study Reviewed

    Satoshi Iyama, Hiroomi Tatsumi, Tsukasa Shiraishi, Masahiro Yoshida, Ayumi Tatekoshi, Akihito Endo, Taichiro Ishige, Yuh Shiwa, Soushi Ibata, Akari Goto, Kana Nagashima, Hiroto Horiguchi, Chisa Fujita, Hiroshi Ikeda, Kohichi Takada, Takayuki Nobuoka, Yusuke Kamihara, Shohei Kikuchi, Tsutomu Sato, Hirofumi Ohnishi, Shin-ichi Yokota, Masayoshi Kobune

    Nutrition   83   111093 - 111093   2021.3

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    Authorship：Lead author,　Corresponding author   Publishing type：Research paper (scientific journal)   Publisher：Elsevier BV  

    DOI： 10.1016/j.nut.2020.111093

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  • Successful mycophenolate mofetil treatment of a patient with severe steroid‐refractory hepatitis evoked by nivolumab plus ipilimumab treatment for relapsed bladder cancer

    Ginji Omori, Kohichi Takada, Kazuyuki Murase, Naotaka Hayasaka, Hajime Nakamura, Satoshi Iyama, Hiroyuki Ohnuma, Koji Miyanishi, Fumimasa Fukuta, Toshiaki Tanaka, Naoya Masumori, Junji Kato

    Clinical Case Reports   9 ( 2 )   654 - 659   2021.2

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    Publishing type：Research paper (scientific journal)   Publisher：Wiley  

    Other Link： https://onlinelibrary.wiley.com/doi/full-xml/10.1002/ccr3.3597

    DOI： 10.1002/ccr3.3597

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  • Isatuximab monotherapy in relapsed/refractory multiple myeloma: A Japanese, multicenter, phase 1/2, safety and efficacy study Reviewed International journal

    Kazutaka Sunami, Kenshi Suzuki, Masaki Ri, Morio Matsumoto, Chihiro Shimazaki, Hideki Asaoku, Hirohiko Shibayama, Kenichi Ishizawa, Hiroyuki Takamatsu, Takashi Ikeda, Dai Maruyama, Hitomi Kaneko, Michihiro Uchiyama, Toru Kiguchi, Satoshi Iyama, Hirokazu Murakami, Keishiro Takahashi, Keisuke Tada, Sandrine Macé, Hélène Guillemin‐Paveau, Shinsuke Iida

    Cancer Science   111 ( 12 )   4526 - 4539   2020.12

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    Language：English   Publishing type：Research paper (scientific journal)   Publisher：Wiley  

    Isatuximab, an anti-CD38 monoclonal antibody, targets cells that strongly express CD38 including malignant plasma cells. This open-label, single-arm, multicenter, phase 1/2 trial investigated the tolerability/safety and efficacy of isatuximab monotherapy in Japanese patients with heavily pretreated, relapsed/refractory multiple myeloma (RRMM). In Phase 1, patients were sequentially assigned to receive isatuximab once weekly (QW) in cycle 1 (4 weeks) and every 2 weeks (Q2W) in subsequent cycles. Cohort 1 (n = 3) received 10 mg/kg QW/Q2W; cohort 2 (n = 5) received 20 mg/kg QW/Q2W. No dose-limiting toxicities occurred; the recommended dose for the single-arm phase 2 study (n = 28) was 20 mg/kg QW/Q2W. The overall safety profile was consistent with the current knowledge of isatuximab. The most common adverse events were infusion reactions (42.9%; 12/28); all were grade 1/2 and generally occurred during the first infusion. The overall response rate with 20 mg/kg QW/Q2W isatuximab was 36.4% (12/33); patients with high-risk cytogenetic abnormalities had comparable results. In phase 2, the median progression-free survival was 4.7 (95% confidence interval, 3.75 to not reached) months. Median overall survival was not reached. Isatuximab monotherapy was well tolerated and effective in patients with heavily pretreated RRMM including high-risk cytogenetic patients. This trial is registered at ClinicalTrials.gov as NCT02812706.

    Other Link： https://onlinelibrary.wiley.com/doi/full-xml/10.1111/cas.14657

    DOI： 10.1111/cas.14657

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  • Successful Treatment by Surgery and Lenvatinib of a Patient with Adrenal Metastasis of Papillary Thyroid Cancer

    Hajime Nakamura, Kohichi Takada, Kazuyuki Murase, Hiroki Sakamoto, Naotaka Hayasaka, Kazuma Ishikawa, Yuki Ikeda, Makoto Yoshida, Satoshi Iyama, Ko Kobayashi, Tetsuya Shindo, Shintaro Sugita, Koji Miyanishi, Masayoshi Kobune, Naoya Masumori, Junji Kato

    Case Reports in Oncological Medicine   2020   1 - 4   2020.11

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    Publishing type：Research paper (scientific journal)   Publisher：Hindawi Limited  

    Papillary thyroid cancer (PTC) is considered an indolent cancer, but some PTC patients do present with distant metastases and treatment strategies for such patients are not well established. Recently, lenvatinib, an inhibitor of multiple tyrosine kinases, has been introduced to treat patients with advanced PTC but carries a risk of serious adverse events such as hemorrhage. Here, we report a PTC patient with a left adrenal metastasis and lenvatinib-induced hemorrhage who underwent successful surgical resection and was subsequently treated with a lower dose of lenvatinib. The patient has now been in a stable state with no adverse events for nearly two years. This case highlights the importance of surgical resection of metastatic PTC and subsequent lenvatinib therapy, even when the tumor is at an advanced stage.

    Other Link： http://downloads.hindawi.com/journals/crionm/2020/2107430.xml

    DOI： 10.1155/2020/2107430

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  • Acquired amegakaryocytic thrombocytopenic purpura possibly induced by anti-PD-1 antibody Reviewed

    Satoshi Iyama, K. Takada, M. Yoshida, D. Takahashi, M. Kobune

    Annals of Hematology   99 ( 7 )   1669 - 1670   2020.7

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    Authorship：Lead author,　Corresponding author   Publishing type：Research paper (scientific journal)   Publisher：Springer Science and Business Media LLC  

    Other Link： https://link.springer.com/article/10.1007/s00277-020-04053-y/fulltext.html

    DOI： 10.1007/s00277-020-04053-y

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  • Prospective evaluation of alternative donor from unrelated donor and cord blood in adult acute leukemia and myelodysplastic syndrome Reviewed

    Seitaro Terakura, Tetsuya Nishida, Masashi Sawa, Tomonori Kato, Kotaro Miyao, Yukiyasu Ozawa, Tatsunori Goto, Akio Kohno, Kazutaka Ozeki, Yasushi Onishi, Noriko Fukuhara, Nobuharu Fujii, Hisayuki Yokoyama, Masanobu Kasai, Hiroatsu Iida, Nobuhiro Kanemura, Tomoyuki Endo, Hiroatsu Ago, Makoto Onizuka, Satoshi Iyama, Yuichiro Nawa, Mika Nakamae, Yasuyuki Nagata, Shingo Kurahashi, Yasuo Tomiya, Atsumi Yanagisawa, Ritsuro Suzuki, Yachiyo Kuwatsuka, Yoshiko Atsuta, Koichi Miyamura, Makoto Murata

    Bone Marrow Transplantation   55 ( 7 )   1399 - 1409   2020.7

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    Publishing type：Research paper (scientific journal)   Publisher：Springer Science and Business Media LLC  

    Other Link： http://www.nature.com/articles/s41409-020-0859-8

    DOI： 10.1038/s41409-020-0859-8

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  • Successful brentuximab vedotin monotherapy against late relapse of classical Hodgkin lymphoma 6 years after first remission

    Kana Nagashima, Shohei Kikuchi, Satoshi Iyama, Chisa Fujita, Akari Goto, Hiroto Horiguchi, Masayoshi Kobune

    Clinical Case Reports   8 ( 3 )   466 - 468   2020.3

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    Language：English   Publishing type：Research paper (scientific journal)   Publisher：Wiley-Blackwell Publishing Ltd  

    DOI： 10.1002/ccr3.2688

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  • Blastic plasmacytoid dendritic cell neoplasm(BPDCN)の2例

    執行 延明, 西田 彩華, 菅野 莉英, 藤岡 茉生, 大橋 隆宏, 堀本 浩平, 加藤 潤史, 肥田 時征, 宇原 久, 村瀬 和幸, 井山 諭, 須釜 佑介, 前田 和男

    日本皮膚科学会雑誌   130 ( 3 )   418 - 418   2020.3

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    Language：Japanese   Publisher：(公社)日本皮膚科学会  

    Ichushi

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  • Exceptionally rapid response to pembrolizumab in a SMARCA4‐deficient thoracic sarcoma overexpressing PD‐L1: A case report

    Kohichi Takada, Shintaro Sugita, Kazuyuki Murase, Tomoki Kikuchi, Ginji Oomori, Ryo Ito, Naotaka Hayasaka, Koji Miyanishi, Satoshi Iyama, Hiroshi Ikeda, Masayoshi Kobune, Makoto Emori, Junji Kato, Tadashi Hasegawa

    Thoracic Cancer   10 ( 12 )   2312 - 2315   2019.12

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    Publishing type：Research paper (scientific journal)   Publisher：Wiley  

    Other Link： https://onlinelibrary.wiley.com/doi/full-xml/10.1111/1759-7714.13215

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  • DPP8 is a novel therapeutic target for multiple myeloma Reviewed

    Tsutomu Sato, Ayumi Tatekoshi, Kohichi Takada, Satoshi Iyama, Yusuke Kamihara, Paras Jawaid, Mati Ur Rehman, Kyo Noguchi, Takashi Kondo, Sayaka Kajikawa, Kotaro Arita, Akinori Wada, Jun Murakami, Miho Arai, Ichiro Yasuda, Nam H. Dang, Ryo Hatano, Noriaki Iwao, Kei Ohnuma, Chikao Morimoto

    Scientific Reports   9 ( 1 )   2019.12

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    <title>Abstract</title>Dipeptidyl peptidases (DPPs) are proteolytic enzymes that are ideal therapeutic targets in human diseases. Indeed, DPP4 inhibitors are widely used in clinical practice as anti-diabetic agents. In this paper, we show that DPP4 inhibitors also induced cell death in multiple human myeloma cells. Among five DPP4 inhibitors, only two of them, vildagliptin and saxagliptin, exhibited apparent cytotoxic effects on myeloma cell lines, without any difference in suppression of DPP4 activity. As these two DPP4 inhibitors are known to have off-target effects against DPP8/9, we employed the specific DPP8/9 inhibitor 1G244. 1G244 demonstrated anti-myeloma effects on several cell lines and CD138+ cells from patients as well as in murine xenograft model. Through siRNA silencing approach, we further confirmed that DPP8 but not DPP9 is a key molecule in inducing cell death induced by DPP8/9 inhibition. In fact, the expression of DPP8 in CD38+ cells from myeloma patients was higher than that of healthy volunteers. DPP8/9 inhibition induced apoptosis, as evidenced by activated form of PARP, caspases-3 and was suppressed by the pan-caspase inhibitor Z-VAD-FMK. Taken together, these results indicate that DPP8 is a novel therapeutic target for myeloma treatment.

    Other Link： http://www.nature.com/articles/s41598-019-54695-w

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  • Pneumothorax as an Adverse Event in Patients with Lung Metastasis of Soft Tissue Sarcoma under Eribulin Treatment

    Kohichi Takada, Kazuyuki Murase, Hajime Nakamura, Naotaka Hayasaka, Yohei Arihara, Satoshi Iyama, Hiroshi Ikeda, Makoto Emori, Shintaro Sugita, Katsuyuki Nakamura, Koji Miyanishi, Masayoshi Kobune, Junji Kato

    Internal Medicine   58 ( 20 )   3009 - 3012   2019.10

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    DOI： 10.2169/internalmedicine.2790-19

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  • EPO-R+ myelodysplastic cells with ring sideroblasts produce high erythroferrone levels to reduce hepcidin expression in hepatic cells

    Shogo Miura, Masayoshi Kobune, Hiroto Horiguchi, Shohei Kikuchi, Satoshi Iyama, Kazuyuki Murase, Akari Goto, Hiroshi Ikeda, Kohichi Takada, Koji Miyanishi, Junji Kato

    Blood Cells, Molecules, and Diseases   78   1 - 8   2019.9

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  • Six-transmembrane epithelial antigen of the prostate 1 protects against increased oxidative stress via a nuclear erythroid 2-related factor pathway in colorectal cancer

    Hajime Nakamura, Kohichi Takada, Yohei Arihara, Naotaka Hayasaka, Kazuyuki Murase, Satoshi Iyama, Masayoshi Kobune, Koji Miyanishi, Junji Kato

    Cancer Gene Therapy   26 ( 9-10 )   313 - 322   2019.9

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  • Blastic plasmacytoid dendritic cell neoplasm(BPDCN)の1例

    執行 延明, 西田 彩華, 菅野 莉英, 藤岡 茉生, 大橋 隆宏, 堀本 浩平, 加藤 潤史, 肥田 時征, 宇原 久, 井山 諭, 前田 和男, 須釜 佑介

    日本皮膚科学会雑誌   129 ( 9 )   1910 - 1910   2019.8

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  • Combination of eribulin plus AKT inhibitor evokes synergistic cytotoxicity in soft tissue sarcoma cells. Reviewed International journal

    Naotaka Hayasaka, Kohichi Takada, Hajime Nakamura, Yohei Arihara, Yutaka Kawano, Takahiro Osuga, Kazuyuki Murase, Shohei Kikuchi, Satoshi Iyama, Makoto Emori, Shintaro Sugita, Tadashi Hasegawa, Akira Takasawa, Koji Miyanishi, Masayoshi Kobune, Junji Kato

    Scientific reports   9 ( 1 )   5759 - 5759   2019.4

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    An activated AKT pathway underlies the pathogenesis of soft tissue sarcoma (STS), with over-expressed phosphorylated AKT (p-AKT) correlating with a poor prognosis in a subset of STS cases. Recently, eribulin, a microtubule dynamics inhibitor, has demonstrated efficacy and is approved in patients with advanced/metastatic liposarcoma and breast cancer. However, mechanisms of eribulin resistance and/or insensitivity remain largely unknown. In this study, we demonstrated that an increased p-AKT level was associated with eribulin resistance in STS cells. We found a combination of eribulin with the AKT inhibitor, MK-2206, synergistically inhibited STS cell growth in vivo as well as in vitro. Mechanistically, eribulin plus MK-2206 induced G1 or G2/M arrest by down-regulating cyclin-dependent kinases, cyclins and cdc2, followed by caspase-dependent apoptosis in STS cells. Our findings demonstrate the significance of p-AKT signaling for eribulin-resistance in STS cells and provide a rationale for the development of an AKT inhibitor in combination with eribulin to treat patients with STS.

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  • miR-7977 inhibits the Hippo-YAP signaling pathway in bone marrow mesenchymal stromal cells. Reviewed International journal

    Masahiro Yoshida, Hiroto Horiguchi, Shohei Kikuchi, Satoshi Iyama, Hiroshi Ikeda, Akari Goto, Yutaka Kawano, Kazuyuki Murase, Kohichi Takada, Koji Miyanishi, Junji Kato, Masayoshi Kobune

    PloS one   14 ( 3 )   e0213220   2019

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    We and others have demonstrated that various abnormalities of the bone marrow (BM) mesenchymal stromal cells (MSCs) such as aberrant cytokine expression, abnormal hedgehog signaling, and impaired miRNA biogenesis are observed in patients with acute myeloid leukemia (AML). However, underlying mechanisms to induce the dysfunction of BM MSCs have not yet been clarified. We previously showed that AML cells release abundant exosomal miR-7977, which, in turn, enters BM mesenchymal stromal cells (MSCs). However, the precise function of miR-7977 is not known. In this study, we performed transduction of a miR-7977 mimic into MSCs, compared transcriptomes between control-transduced (n = 3) and miR-7977-transduced MSCs (n = 3), and conducted pathway analysis. The array data revealed that the expression of 0.05% of genes was reduced 2-fold and the expression of 0.01% of genes was increased 2-fold. Interestingly, approximately half of these genes possessed a miR-7977 target site, while the other genes did not, suggesting that miR-7977 regulates the gene expression level directly and indirectly. Gene set enrichment analysis showed that the gene sets of Yes-associated protein 1 (YAP1) _up were significantly enriched (p<0.001, q<0.25), suggesting that miR-7977 modulates the Hippo-YAP signaling pathway. Visualization of pathway and network showed that miR-7977 significantly reduced the expression of Hippo core kinase, STK4. miR-7977 inactivated the Hippo-YAP signaling pathway as proven by GFP-tagged YAP nuclear trans localization and TEAD reporter assay. The miR-7977-transduced MSC cell line, HTS-5, showed elevated saturation density and enhanced entry into the cell cycle. These results suggest that miR-7977 is a critical factor that regulates the Hippo-YAP signaling pathway in BM-MSCs and may be involved in the upregulation of leukemia-supporting stroma growth.

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  • Denosumab prevents bone loss in newly diagnosed malignant lymphoma patients undergoing corticosteroid-containing chemotherapy: A prospective, non-randomized study

    Ayumi Tatekoshi, Tsutomu Sato, Satoshi Iyama, Kohichi Takada, Kazuyuki Murase, Masahiro Yoshida, Soushi Ibata, Akari Hashimoto, Yusuke Kamihara, Hiroto Horiguchi, Koji Miyanishi, Masayoshi Kobune, Junji Kato

    Sapporo Medical journal   87 ( 1-6 )   35 - 47   2018.12

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  • Long-term prognosis of human herpesvirus 6 reactivation following allogeneic hematopoietic stem cell transplantation. Reviewed International journal

    Kotoe Iesato, Tsukasa Hori, Yuko Yoto, Masaki Yamamoto, Natsuko Inazawa, Kenichi Kamo, Hiroshi Ikeda, Satoshi Iyama, Naoki Hatakeyama, Akihiro Iguchi, Junichi Sugita, Ryoji Kobayashi, Nobuhiro Suzuki, Hiroyuki Tsutsumi

    Pediatrics international : official journal of the Japan Pediatric Society   60 ( 6 )   547 - 552   2018.6

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    BACKGROUND: Patients undergoing hematopoietic stem cell transplantation (HSCT) frequently have HHV-6 reactivation typically during the early phase following HSCT. The long-term clinical complications and prognosis, however, remain unclear. METHODS: Between September 2010 and October 2012, whole blood samples from 105 patients collected weekly from prior to 6 weeks after HSCT underwent multiplex polymerase chain reaction (PCR) to screen for viral DNA, followed by real-time PCR for quantitative estimation. In 48 patients, only HHV-6 was detected in at least one sample. In 30 patients, no viral DNA was detected. Long-term clinical records were reviewed in March 2016. All 48 HHV-6-positive patients, and 24 patients in whom no viral DNA detected, were followed up. RESULTS: Median maximum HHV-6 DNA load in the blood of the HHV-6 reactivation group (n = 48) was 11 800 copies/μg peripheral blood leukocyte DNA (range, 52-310 000 000). Hemophagocytic syndrome (HPS) was diagnosed in two subjects with HHV-6 reactivation. Acute graft-versus-host disease (GVHD) developed more frequently in patients with HHV-6 reactivation than in patients without viral reactivation (P = 0.002), but there was no difference in incidence of chronic GVHD. There was no difference in engraftment of neutrophils and platelets between groups. There was also no difference in overall survival between groups. Onset of HPS, however, was associated with lower overall survival (P = 0.009). CONCLUSIONS: Human herpesvirus 6 reactivation was associated with acute GVHD, but not with chronic GVHD, engraftment or overall survival. Onset of HPS, however, predicts lower overall survival.

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  • High expression of nucleoporin 133 mRNA in bone marrow CD138+ cells is a poor prognostic factor in multiple myeloma Reviewed

    Soushi Ibata, Masayoshi Kobune, Shohei Kikuchi, Masahiro Yoshida, Shogo Miura, Hiroto Horiguchi, Kazuyuki Murase, Satoshi Iyama, Kohichi Takada, Koji Miyanishi, Junji Kato

    Oncotarget   9 ( 38 )   25127 - 25135   2018.5

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    DOI： 10.18632/oncotarget.25350

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  • ART療法中に多発血栓症を併発した悪性リンパ腫患者の一例

    池田 博, 吉田 正宏, 舘越 鮎美, 菊地 尚平, 村瀬 和幸, 高田 弘一, 井山 諭, 小船 雅義, 村上 則子, 宮越 郁子, 又村 了輔, 國本 雄介, 加藤 淳二

    日本エイズ学会誌   19 ( 4 )   501 - 501   2017.11

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  • Small molecule CP-31398 induces reactive oxygen species-dependent apoptosis in human multiple myeloma Reviewed

    Yohei Arihara, Kohichi Takada, Yusuke Kamihara, Naotaka Hayasaka, Hajime Nakamura, Kazuyuki Murase, Hiroshi Ikeda, Satoshi Iyama, Tsutomu Sato, Koji Miyanishi, Masayoshi Kobune, Junji Kato

    ONCOTARGET   8 ( 39 )   65889 - 65899   2017.9

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  • [A Case of Chronic Myelogenous Leukemia That Developed Fibrous Pericarditis Owing to Nilotinib Use]. Reviewed

    Shogo Miura, Kazuyuki Murase, Akira Sakurada, Kohichi Takada, Satoshi Iyama, Tsutomu Sato, Yasushi Sato, Koji Miyanishi, Masayoshi Kobune, Atsuko Muranaka, Kazutoshi Tachibana, Junji Kato

    Gan to kagaku ryoho. Cancer & chemotherapy   44 ( 6 )   529 - 531   2017.6

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    A 64-year-old man was diagnosed with chronic-phase chronic myelogenous leukemia(CML)in May 2009. He was treated with imatinib and achieved complete cytogenetic response(CCyR)in 2 months. After 4 months of treatment, he developed interstitial pneumonia and became intolerant to imatinib. He was then switched to nilotinib from October of the same year. In June 2013, he was diagnosed with drug-induced pericarditis resulting from nilotinib use, and thus, nilotinib was discontinued. Subsequently, he was followed up without specific treatment for CML. In January 2014, he was admitted to the Dept. of Cardiovascular, Renal and Metabolic Medicine at our hospital because of heart failure. After examinations of cardiac function, he was diagnosed with constrictive pericarditis. Therefore, pericardiolysis was performed by the Dept. of Cardiovascular Surgery at our hospital. Pathologic findings showed hyaline-like fibrous tissue proliferation in the pericardium, which was diagnosed as fibrous pericarditis induced by nilotinib. We report a case of chronic myelogenous leukemia that developed fibrous pericarditis owing to nilotinib use.

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  • 低分子化合物CP-31398は多発性骨髄腫に対して活性酸素種依存的なアポトーシスを誘導する Reviewed

    在原 洋平, 高田 弘一, 神原 悠輔, 河野 豊, 早坂 尚貴, 中村 元, 菊地 尚平, 村瀬 和幸, 井山 諭, 池田 博, 佐藤 勉, 宮西 浩嗣, 小船 雅義, 加藤 淳二

    International Journal of Myeloma   7 ( 1 )   76 - 76   2017.4

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  • A Multicenter Retrospective Study of Mogamulizumab Efficacy in Adult T-Cell Leukemia/Lymphoma Reviewed

    Satoshi Iyama, Tsutomu Sato, Hirofumi Ohnishi, Yuji Kanisawa, Shuichi Ohta, Takeshi Kondo, Akio Mori, Yutaka Tsutsumi, Hiroyuki Kuroda, Yasutaka Kakinoki, Satoshi Yamamoto, Tohru Takahashi, Motohiro Shindo, Yoshihiro Torimoto, Kazuya Sato, Hiroshi Iwasaki, Yoshihito Haseyama, Kyuhei Kohda, Yasuhiro Nagamachi, Yasuo Hirayama, Hajime Sakai, Yasuji Hirata, Takashi Fukuhara, Hiroshi Ikeda, Masayoshi Kobune, Junji Kato, Mitsutoshi Kurosawa

    CLINICAL LYMPHOMA MYELOMA & LEUKEMIA   17 ( 1 )   23 - 30   2017.1

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    DOI： 10.1016/j.clml.2016.09.009

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  • A phase II trial of small-dose bortezomib, lenalidomide and dexamethasone (sVRD) as consolidation/maintenance therapy in patients with multiple myeloma Reviewed

    Soushi Ibata, Tsutomu Sato, Hiroyuki Kuroda, Yasuhiro Nagamachi, Satoshi Iyama, Akihito Fujimi, Yusuke Kamihara, Yuichi Konuma, Masahiro Yoshida, Ayumi Tatekoshi, Akari Hashimoto, Hiroto Horiguchi, Kaoru Ono, Kazuyuki Murase, Kohichi Takada, Koji Miyanishi, Masayoshi Kobune, Yasuo Hirayama, Junji Kato

    CANCER CHEMOTHERAPY AND PHARMACOLOGY   78 ( 5 )   1041 - 1049   2016.11

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    DOI： 10.1007/s00280-016-3163-y

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  • Phase I/IIa Study of Low Dose Subcutaneous Interleukin-2 (IL-2) for Treatment of Refractory Chronic Graft Versus Host Disease Reviewed

    Takeru Asano, Ken-Ichi Matsuoka, Satoshi Iyama, Kazuteru Ohashi, Yoshihiro Inamoto, Chikako Ohwada, Makoto Murata, Atsushi Satake, Chikamasa Yoshida, Koichi Nakase, Yasuo Mori, Mitsune Tanimoto

    ACTA MEDICA OKAYAMA   70 ( 5 )   429 - 433   2016.10

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  • The iron chelator deferasirox induces apoptosis by targeting oncogenic Pyk2/β-catenin signaling in human multiple myeloma. Reviewed International journal

    Yusuke Kamihara, Kohichi Takada, Tsutomu Sato, Yutaka Kawano, Kazuyuki Murase, Yohei Arihara, Shohei Kikuchi, Naotaka Hayasaka, Makoto Usami, Satoshi Iyama, Koji Miyanishi, Yasushi Sato, Masayoshi Kobune, Junji Kato

    Oncotarget   7 ( 39 )   64330 - 64341   2016.9

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    Deregulated iron metabolism underlies the pathogenesis of many human cancers. Recently, low expression of ferroportin, which is the only identified non-heme iron exporter, has been associated with significantly reduced overall survival in multiple myeloma (MM); however, the altered iron metabolism in MM biology remains unclear. In this study we demonstrated, by live cell imaging, that MM cells have increased intracellular iron levels as compared with normal cells. In experiments to test the effect of iron chelation on the growth of MM cells, we found that deferasirox (DFX), an oral iron chelator used to treat iron overload in clinical practice, inhibits MM cell growth both in vivo and in vitro. Mechanistically, DFX was found to induce apoptosis of MM cells via the inhibition of proline-rich tyrosine kinase 2 (Pyk2), which is known to promote tumor growth in MM. Inhibition of Pyk2 is caused by the suppression of reactive oxygen species, and leads to downregulation of the Wnt/β-catenin signaling pathway. Taken together, our findings indicate that high levels of intracellular iron, which might be due to low ferroportin expression, play a role in MM pathophysiology. Therefore, DFX may provide a therapeutic option for MM that is driven by deregulated iron homeostasis and/or Pyk2/Wnt signaling.

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  • Relationship Between Increased Fucosylation and Metastatic Potential in Colorectal Cancer. Reviewed International journal

    Takahiro Osuga, Rishu Takimoto, Michihiro Ono, Masahiro Hirakawa, Makoto Yoshida, Yutaka Okagawa, Naoki Uemura, Yohei Arihara, Yasushi Sato, Fumito Tamura, Tsutomu Sato, Satoshi Iyama, Koji Miyanishi, Kohichi Takada, Tsuyoshi Hayashi, Masayoshi Kobune, Junji Kato

    Journal of the National Cancer Institute   108 ( 9 )   2016.9

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    BACKGROUND: Fucose is utilized for the modification of different molecules involved in blood group determination, immunological reactions, and signal transduction pathways. We have recently reported that enhanced activity of the fucosyltransferase 3 and/or 6 promoted TGF-ß-mediated epithelial mesenchymal transition and was associated with increased metastatic potential of colorectal cancer (CRC), suggesting that fucose is required by CRC cells. With this in mind, we examined requirement of L-fucose in CRC cells and developed fucose-bound nanoparticles as vehicles for delivery of anticancer drugs specific to CRC. METHODS: In this study, we first examined the expression of fucosylated proteins in 50 cases of CRC by immunochistochemical staining with biotinylated Aleuria aurantia lectin (AAL). Then we carried out an L-fucose uptake assay using three CRC cell lines. Finally, we developed fucose-bound nanoparticles as vehicles for the delivery of an anticancer drug, SN38, and examined tumor growth inhibition in mouse xenograft model (n = 6 mice per group). All statistical tests were two-sided. RESULTS: We found a statistically significant relationship between vascular invasion, clinical stage, and intensity score of AAL staining (P ≤ .02). L-fucose uptake assay revealed that L-fucose incorporation, as well as fucosylated protein release, was high in cells rich in fucosylated proteins. L-fucose-bound liposomes effectively delivered Cy5.5 into CRC cells. The excess of L-fucose decreased the efficiency of Cy5.5 uptake through L-fucose-bound liposomes, suggesting an L-fucose receptor dependency. Intravenously injected, L-fucose-bound liposomes carrying SN38 were successfully delivered to CRC cells, mediating efficient tumor growth inhibition (relative tumor growth ratio: no treatment group [NT], 8.29 ± 3.09; SN38-treated group [SN38], 3.53 ± 1.47; liposome-carrying, SN38-treated group [F0], 3.1 ± 1.39; L-fucose-bound, liposome-carrying, SN38-treated group [F50], 0.94 ± 0.89; F50 vs NT, P = .003; F50 vs SN38, P = .02, F50 vs F0, P = .04), as well as prolonging survival of mouse xenograft models (log-rank test, P < .001). CONCLUSIONS: Thus, fucose-bound liposomes carrying anticancer drugs provide a new strategy for the treatment of CRC patients.

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  • [Treatment Outcomes of Adult-Onset Ewing Sarcoma: A Single-Center Retrospective Study of Five Cases]. Reviewed

    Kazuyuki Murase, Kohichi Takada, Yusuke Kamihara, Makoto Usami, Masahiro Yoshida, Ayumi Tatekoshi, Akari Hashimoto, Yohei Arihara, Naotaka Hayasaka, Shogo Miura, Satoshi Iyama, Tsutomu Sato, Yasushi Sato, Koji Miyanishi, Masayoshi Kobune, Makoto Emori, Mitsunori Kaya, Toshihiko Yamashita, Shintaro Sugita, Tadashi Hasegawa, Junji Kato

    Gan to kagaku ryoho. Cancer & chemotherapy   43 ( 8 )   1015 - 8   2016.8

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    UNLABELLED: We report the treatment outcomes of 5 cases of adult-onset Ewing sarcoma(ES)managed between 2011 and 2014. We examined prognostic factors including the primary lesion, tumor size, metastatic status, and serum LDH levels. RESULTS: The locations of the primary lesions included the limbs in 1 case and the trunk in 4; the cases in the trunk had a worse prognosis than that in the limbs. Tumor size was greater than 8 cm in only 1 patient, who also displayed evidence of metastases at presentation and high LDH levels. All the patients received chemotherapy consisting of alternating vincristine, doxorubicin, and cyclophosphamide(VDC)and etoposide and ifosfamide(IE). Surgery was selected for the treatment of 4 patients, and radiotherapy was administered to 1 patient for local treatment of the tumor. A median follow-up duration of 31.6 months revealed the 2-year overall survival rate and progression-free survival rate to be 80.0%. CONCLUSIONS: The prognosis of patients with adult-onset ES is poor; however, combined modality therapy, including VDC-IE, was demonstrated to improve the outcome of patients in the present study. Nevertheless, the patient with tumor size exceeding 8 cm, metastasis, and high LDH levels, relapsed 1 year after treatment, as reported previously. Further investigation is required to clarify the factors affecting prognosis in adults, and to develop effective therapies for patients with a poor prognosis.

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  • Relationship Between Increased Fucosylation and Metastatic Potential in Colorectal Cancer Reviewed

    Takahiro Osuga, Rishu Takimoto, Michihiro Ono, Masahiro Hirakawa, Makoto Yoshida, Yutaka Okagawa, Naoki Uemura, Yohei Arihara, Yasushi Sato, Fumito Tamura, Tsutomu Sato, Satoshi Iyama, Koji Miyanishi, Kohichi Takada, Tsuyoshi Hayashi, Masayoshi Kobune, Junji Kato

    JNCI-JOURNAL OF THE NATIONAL CANCER INSTITUTE   108 ( 8 )   2016.8

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  • Targeting Notch-1 positive acute leukemia cells by novel fucose-bound liposomes carrying daunorubicin Reviewed

    Michihiro Ono, Rishu Takimoto, Takahiro Osuga, Yutaka Okagawa, Masahiro Hirakawa, Makoto Yoshida, Yohei Arihara, Naoki Uemura, Naoki Hayasaka, Shogo Miura, Teppei Matsuno, Fumito Tamura, Yasushi Sato, Tsutomu Sato, Satoshi Iyama, Koji Miyanishi, Kohichi Takada, Masayoshi Kobune, Junji Kato

    ONCOTARGET   7 ( 25 )   38586 - 38597   2016.6

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  • Efficacy of upfront high-dose chemotherapy plus rituximab followed by autologous peripheral blood stem cell transplantation for untreated high-intermediate-, and high-risk diffuse large B-cell lymphoma: a multicenter prospective phase II study (JSCT-NHL04) Reviewed

    Tohru Murayama, Takahiro Fukuda, Hirokazu Okumura, Kazutaka Sunami, Aiko Sawazaki, Yoshinobu Maeda, Hisashi Tsurumi, Naokuni Uike, Tomonori Hidaka, Yoshifusa Takatsuka, Tetsuya Eto, Hiroyuki Tsuda, Tomoaki Fujisaki, Toshihiro Miyamoto, Naoko Tsuneyoshi, Satoshi Iyama, Koji Nagafuji, Mine Harada

    INTERNATIONAL JOURNAL OF HEMATOLOGY   103 ( 6 )   676 - 685   2016.6

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  • Isoform D of vascular endothelial growth factor in systemic capillary leak syndrome: a case report. Reviewed International journal

    Soushi Ibata, Tsutomu Sato, Kohichi Takada, Ayumi Tatekoshi, Akari Hashimoto, Yusuke Kamihara, Wataru Jomen, Hiroto Horiguchi, Kaoru Ono, Kazuyuki Murase, Satoshi Iyama, Koji Miyanishi, Yasushi Sato, Rishu Takimoto, Masayoshi Kobune, Junji Kato

    Journal of medical case reports   10   125 - 125   2016.5

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    BACKGROUND: Systemic capillary leak syndrome is a rare condition characterized by episodic attacks of hypovolemia due to systemic capillary hyperpermeability, which results in profound hypotension and edema. Although the implication of vascular endothelial growth factor, angiopoietin-2, and C-X-C motif chemokine 10 has been suggested, the pathogenesis of systemic capillary leak syndrome remains unclear. In this report, we describe a case of systemic capillary leak syndrome in which serum isoform D of vascular endothelial growth factor was elevated. To the best of our knowledge, this is the first reported case of systemic capillary leak syndrome in which isoform D of vascular endothelial growth factor is suggested as the plausible biomarker. CASE PRESENTATION: A 41-year-old Japanese man was transferred to our emergency department. He was hypotensive, tachycardic, and edematous over the trunk and all four limbs. He received aggressive intravenous fluid therapy and underwent fasciotomy of the right forearm to prevent muscle necrosis. A diagnosis of systemic capillary leak syndrome was suspected. The presence of serum monoclonal immunoglobulin G and κ light chain supported this diagnosis. Prevention of hypotensive crises was unsuccessfully attempted with theophylline, intravenous immunoglobulin, high-dose dexamethasone, bortezomib, melphalan, and prednisolone; however, the patient's attacks dramatically disappeared after the introduction of thalidomide. The serum of the patient was stored soon after the onset of hypotensive crisis and analyzed to profile possible mediators responsible for the capillary leak. The concentration of vascular endothelial growth factor, angiopoietin-2, and C-X-C motif chemokine 10 were all within normal ranges. Meanwhile, we found that isoform D of vascular endothelial growth factor was elevated, which was normalized after the introduction of thalidomide. CONCLUSIONS: In our patient, isoform D of vascular endothelial growth factor (instead of vascular endothelial growth factor) may have been a causative factor of hypotensive crises, since isoform D contributes to vascular endothelial growth factor receptor-2 signaling, which is the major mediator of the permeability-enhancing effects of vascular endothelial growth factor. We suggest the measurement of isoform D of vascular endothelial growth factor in patients with systemic capillary leak syndrome in whose serum vascular endothelial growth factor is not elevated.

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  • Extracellular vesicle miR-7977 is involved in hematopoietic dysfunction of mesenchymal stromal cells via poly(rC) binding protein 1 reduction in myeloid neoplasms Reviewed

    Hiroto Horiguchi, Masayoshi Kobune, Shohei Kikuchi, Masahiro Yoshida, Masaki Murata, Kazuyuki Murase, Satoshi Iyama, Kohichi Takada, Tsutomu Sato, Kaoru Ono, Akari Hashimoto, Ayumi Tatekoshi, Yusuke Kamihara, Yutaka Kawano, Koji Miyanishi, Norimasa Sawada, Junji Kato

    HAEMATOLOGICA   101 ( 4 )   437 - 447   2016.4

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    DOI： 10.3324/haematol.2015.134932

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  • Narrow-Band Ultraviolet B Phototherapy Ameliorates Acute Graft-Versus-Host Disease of the Intestine by Expansion of Regulatory T Cells Reviewed

    Akari Hashimoto, Tsutomu Sato, Satoshi Iyama, Masahiro Yoshida, Soushi Ibata, Ayumi Tatekoshi, Yusuke Kamihara, Hiroto Horiguchi, Kazuyuki Murase, Yutaka Kawano, Kohichi Takada, Koji Miyanishi, Masayoshi Kobune, Shingo Ichimiya, Junji Kato

    PLOS ONE   11 ( 3 )   e0152823   2016.3

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  • [Neurolymphomatosis of the sciatic nerve diagnosed by FDG-PET/CT]. Reviewed

    Usami M, Murase K, Takada K, Iijima K, Yoshida M, Tatekoshi A, Hashimoto A, Iyama S, Sato T, Kobune M, Takimoto R, Kaya M, Yamashita T, Morita R, Hasegawa T, Kato J

    [Rinsho ketsueki] The Japanese journal of clinical hematology   57 ( 1 )   52 - 55   2016.1

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  • RNAi-mediated gene silencing of ST6GalNAc I suppresses the metastatic potential in gastric cancer cells Reviewed

    Fumito Tamura, Yasushi Sato, Masahiro Hirakawa, Makoto Yoshida, Michihiro Ono, Takahiro Osuga, Yutaka Okagawa, Naoki Uemura, Yohei Arihara, Kazuyuki Murase, Yutaka Kawano, Satoshi Iyama, Kohichi Takada, Tsuyoshi Hayashi, Tsutomu Sato, Koji Miyanishi, Masayoshi Kobune, Rishu Takimoto, Junji Kato

    GASTRIC CANCER   19 ( 1 )   85 - 97   2016.1

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  • [RS3PE syndrome associated with senile Epstein-Barr virus-positive diffuse large B cell lymphoma of a patient with colon cancer]. Reviewed

    Shimoyama S, Kuroda H, Yoshida M, Usami M, Sakamoto H, Yamada M, Fujii S, Maeda M, Fujita M, Nakano T, Kanari Y, Iyama S, Kato J

    [Rinsho ketsueki] The Japanese journal of clinical hematology   56 ( 11 )   2329 - 2335   2015.11

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    A 75-year-old woman consulted her doctor in January 2014 because of pain in the dorsum of the hands, elbows, shoulders, and knees, bilaterally, and was diagnosed as having remitting seronegative symmetrical synovitis with pitting edema (RS3PE) syndrome. Although the joint pain improved with low-dose prednisolone administration, she was referred to our department in April of 2014 because she had become aware of swelling of the right cervical lymph node. Biopsy of the lymph node demonstrated that she had Epstein-Barr virus (EBV)-positive diffuse large B-cell lymphoma (DLBCL) of the elderly, and colonoscopy revealed early colon cancer. Also, both the lymphoma and colon cancer stained positive for vascular endothelial growth factor (VEGF). Complete remission was achieved after two courses of R-CHOP, and RS3PE syndrome did not relapse. This case suggested the involvement of VEGF produced by EBV-positive DLBCL in the pathogenesis of RS3PE syndrome.

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  • Effect of duloxetine in Japanese patients with chemotherapy-induced peripheral neuropathy: a pilot randomized trial Reviewed

    Yasuo Hirayama, Kunihiko Ishitani, Yasushi Sato, Satoshi Iyama, Kohichi Takada, Kazuyuki Murase, Hiroyuki Kuroda, Yasuhiro Nagamachi, Yuichi Konuma, Akihito Fujimi, Tamotsu Sagawa, Kaoru Ono, Hiroto Horiguchi, Takeshi Terui, Kazuhiko Koike, Toshiro Kusakabe, Tsutomu Sato, Rishu Takimoto, Masayoshi Kobune, Junji Kato

    INTERNATIONAL JOURNAL OF CLINICAL ONCOLOGY   20 ( 5 )   866 - 871   2015.10

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  • Identification of anti-thrombopoietin receptor antibody in prolonged thrombocytopenia after allogeneic hematopoietic stem cell transplantation treated successfully with eltrombopag Reviewed

    Akihito Fujimi, Yusuke Kamihara, Akari Hashimoto, Yuji Kanisawa, Chisa Nakajima, Naotaka Hayasaka, Shota Yamada, Toshinori Okuda, Shinya Minami, Kaoru Ono, Satoshi Iyama, Junji Kato

    INTERNATIONAL JOURNAL OF HEMATOLOGY   102 ( 4 )   471 - 476   2015.10

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    DOI： 10.1007/s12185-015-1806-0

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  • Therapy-related myelodysplastic syndrome as a late adverse event of definitive chemoradiotherapy for esophageal and oropharyngeal cancer Reviewed

    Yusuke Kamihara, Yasushi Sato, Kohichi Takada, Yutaka Okagawa, Satoshi Iyama, Tsutomu Sato, Koji Miyanishi, Rishu Takimoto, Masayoshi Kobune, Junji Kato

    Journal of Japanese Society of Gastroenterology   112 ( 9 )   1664 - 1673   2015.9

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  • Successful hematopoietic cell transplantation following azacitidine treatment in an acute myeloid leukemia patient with t (3;3) (q21;q26.2) translocation and marked thrombocythemia Reviewed

    Masahiro Yoshida, Hiroyuki Kuroda, Saori Shimoyama, Makoto Usami, Michiko Yamada, Shigeyuki Fujii, Masahiro Maeda, Miri Fujita, Yusuke Kanari, Masanori Sato, Wataru Jornen, Satoshi Iyama, Junji Kato

    Japanese Journal of Cancer and Chemotherapy   42 ( 8 )   1013 - 1017   2015.8

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  • A dose-escalation study of oxaliplatin/capecitabine/irinotecan (XELOXIRI) and bevacizumab as a first-line therapy for patients with metastatic colorectal cancer Reviewed

    Yasushi Sato, Hiroyuki Ohnuma, Masahiro Hirakawa, Minoru Takahashi, Takahiro Osuga, Yutaka Okagawa, Kazuyuki Murase, Kohichi Takada, Yutaka Kawano, Satoshi Iyama, Tsuyoshi Hayashi, Tsutomu Sato, Koji Miyanishi, Rishu Takimoto, Masayoshi Kobune, Kenji Okita, Toru Mizuguchi, Tomohisa Furuhata, Koichi Hirata, Junji Kato

    CANCER CHEMOTHERAPY AND PHARMACOLOGY   75 ( 3 )   587 - 594   2015.3

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    DOI： 10.1007/s00280-014-2672-9

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  • A role for peripherally inserted central venous catheters in the prevention of catheter-related blood stream infections in patients with hematological malignancies Reviewed

    Toshiro Sakai, Kyuhei Kohda, Yuichi Konuma, Yasuko Hiraoka, Yukari Ichikawa, Kaoru Ono, Hiroto Horiguchi, Ayumi Tatekoshi, Kouichi Takada, Satoshi Iyama, Junji Kato

    INTERNATIONAL JOURNAL OF HEMATOLOGY   100 ( 6 )   592 - 598   2014.12

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    DOI： 10.1007/s12185-014-1677-9

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  • Markers of bone metabolism in multiple myeloma patients switched from zoledronic acid to denosumab. Reviewed

    Tatekoshi A, Sato T, Ibata S, Hashimoto A, Kamihara Y, Horiguchi H, Ono K, Takada K, Iyama S, Takimoto R, Kobune M, Kato J

    [Rinsho ketsueki] The Japanese journal of clinical hematology   55 ( 11 )   2271 - 2276   2014.11

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    To date, intravenous drip infusion of zoledronic acid (ZA) has mainly been used for the treatment and prevention of skeletal-related events (SRE) in patients with multiple myeloma (MM). Recently, denosumab, a fully humanized monoclonal antibody against receptor activator of nuclear factor-κB ligand (RANKL), has also become available for the same purpose, but little is known about the impact of switching from ZA to denosumab. Herein, we present a retrospective study on bone metabolic markers in 10 MM patients initially treated with ZA and then switched to denosumab. Consequently, the levels of bone resorption markers, tartrate-resistant acid phosphatase 5b (TRACP-5b) and serum type-I collagen crosslinked N-telopeptide (sNTX), significantly decreased after denosumab treatment, while the levels of bone formation markers, osteocalcin (OC) and bone-specific alkaline phosphatase (BAP), showed no apparent changes. No patient developed severe hypocalcemia with denosumab treatment. In one patient not given chemotherapy, the M-protein level increased after switching from ZA to denosumab and plateaued when ZA was restarted. Based on this finding, we anticipate that switching from ZA to denosumab would exert a stronger suppressive effect on osteoclasts, but the anti-myeloma activity of ZA must be taken into consideration.

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  • Anti-erythropoietin receptor antibody-associated pure red cell aplasia accompanied by Coombs-negative autoimmune hemolytic anemia in a patient with T cell/histiocyte-rich large B cell lymphoma Reviewed

    Akihito Fujimi, Yusuke Kamihara, Yuji Kanisawa, Akari Hashimoto, Chisa Nakajima, Naotaka Hayasaka, Naoki Uemura, Toshinori Okuda, Shinya Minami, Satoshi Iyama, Koichi Takada, Tsutomu Sato, Akinori Hara, Yasunori Iwata, Kengo Furuichi, Takashi Wada, Junji Kato

    INTERNATIONAL JOURNAL OF HEMATOLOGY   100 ( 5 )   490 - 493   2014.11

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    DOI： 10.1007/s12185-014-1652-5

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  • 骨髄癌腫症を来し急激な経過を辿った悪性黒色腫の1例

    澤田 匡秀, 澄川 靖之, 佐藤 さゆり, 菅 裕司, 加藤 潤史, 山下 利春, 橋本 亜香利, 井山 諭

    日本皮膚科学会雑誌   124 ( 10 )   1933 - 1933   2014.9

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  • Effective Treatment of Metastatic Rhabdomyosarcoma with Pazopanib Reviewed

    Akari Hashimoto, Kohichi Takada, Rishu Takimoto, Hiroto Horiguchi, Tsutomu Sato, Satoshi Iyama, Kazuyuki Murase, Kaoru Ono, Ayumi Tatekoshi, Tsuyoshi Hayashi, Koji Miyanishi, Yasushi Sato, Masayoshi Kobune, Yasuo Hirayama, Hiroshi Kitamura, Katsuya Nakanishi, Naoya Masumori, Tadashi Hasegawa, Junji Kato

    Japanese Journal of Cancer and Chemotherapy   41 ( 8 )   1041 - 1044   2014.8

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  • High Level of Serum Soluble Interleukin-2 Receptor at Transplantation Predicts Poor Outcome of Allogeneic Stem Cell Transplantation for Adult T Cell Leukemia Reviewed

    Akio Shigematsu, Naoki Kobayashi, Hiroshi Yasui, Motohiro Shindo, Yasutaka Kakinoki, Kyuhei Koda, Satoshi Iyama, Hiroyuki Kuroda, Yutaka Tsutsumi, Masahiro Imamura, Takanori Teshima

    BIOLOGY OF BLOOD AND MARROW TRANSPLANTATION   20 ( 6 )   801 - 805   2014.6

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    DOI： 10.1016/j.bbmt.2014.02.014

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  • Efficacy of enteral supplementation enriched with glutamine, fiber, and oligosaccharide on mucosal injury following hematopoietic stem cell transplantation Reviewed

    Satoshi Iyama, Tsutomu Sato, Hiroomi Tatsumi, Akari Hashimoto, Ayumi Tatekoshi, Yusuke Kamihara, Hiroto Horiguchi, Soushi Ibata, Kaoru Ono, Kazuyuki Murase, Kohichi Takada, Yasushi Sato, Tsuyoshi Hayashi, Koji Miyanishi, Emi Akizuki, Takayuki Nobuoka, Toru Mizugichi, Rishu Takimoto, Masayoshi Kobune, Koichi Hirata, Junji Kato

    Case Reports in Oncology   7 ( 3 )   692 - 699   2014.4

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    DOI： 10.1159/000368714

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  • Narrowband ultraviolet B phototherapy ameliorates acute graft-versus-host disease by a mechanism involving in vivo expansion of CD4+CD25+Foxp3+regulatory T cells Reviewed

    Satoshi Iyama, Kazuyuki Murase, Tsutomu Sato, Akari Hashimoto, Ayumi Tatekoshi, Hiroto Horiguchi, Yusuke Kamihara, Kaoru Ono, Shohei Kikuchi, Kohichi Takada, Yutaka Kawano, Tsuyoshi Hayashi, Koji Miyanishi, Yasushi Sato, Rishu Takimoto, Masayoshi Kobune, Satoru Mori, Junji Kato, Toshiharu Yamashita, Junji Kato

    INTERNATIONAL JOURNAL OF HEMATOLOGY   99 ( 4 )   471 - 476   2014.4

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    DOI： 10.1007/s12185-014-1530-1

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  • Combination chemotherapy of azacitidine and cetuximab for therapy-related acute myeloid leukemia following oxaliplatin for metastatic colorectal cancer Reviewed

    Akari Hashimoto, Kohichi Takada, Hiroto Horiguchi, Tsutomu Sato, Satoshi Iyama, Kazuyuki Murase, Yusuke Kamihara, Kaoru Ono, Ayumi Tatekoshi, Tsuyoshi Hayashi, Koji Miyanishi, Yasushi Sato, Tomohisa Furuhata, Masayoshi Kobune, Rishu Takimoto, Koichi Hirata, Junji Kato

    Case Reports in Oncology   7 ( 2 )   316 - 322   2014.3

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    DOI： 10.1159/000363100

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  • Radiation-induced leiomyosarcoma of the prostate after brachytherapy for prostatic adenocarcinoma Reviewed

    Hiroto Horiguchi, Kohichi Takada, Yusuke Kamihara, Soushi Ibata, Satoshi Iyama, Tsutomu Sato, Tsuyoshi Hayashi, Koji Miyanishi, Yasushi Sato, Rishu Takimoto, Masayoshi Kobune, Ko Kobayashi, Yasuo Hirayama, Naoya Masumori, Tadashi Hasegawa, Junji Kato

    Case Reports in Oncology   7 ( 2 )   565 - 570   2014.3

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    DOI： 10.1159/000366294

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  • A novel strategy inducing autophagic cell death in Burkitt's lymphoma cells with anti-CD19-targeted liposomal rapamycin Reviewed

    K. Ono, T. Sato, S. Iyama, A. Tatekoshi, A. Hashimoto, Y. Kamihara, H. Horiguchi, S. Kikuchi, Y. Kawano, K. Takada, T. Hayashi, K. Miyanishi, Y. Sato, R. Takimoto, M. Kobune, J. Kato

    BLOOD CANCER JOURNAL   4   2014.2

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  • Fucosylated TGF-beta receptors transduces a signal for epithelial-mesenchymal transition in colorectal cancer cells Reviewed

    M. Hirakawa, R. Takimoto, F. Tamura, M. Yoshida, M. Ono, K. Murase, Y. Sato, T. Osuga, T. Sato, S. Iyama, K. Miyanishi, K. Takada, T. Hayashi, M. Kobune, J. Kato

    BRITISH JOURNAL OF CANCER   110 ( 1 )   156 - 163   2014.1

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    DOI： 10.1038/bjc.2013.699

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  • Successful Treatment with Entecavir for Reactivation of Hepatitis B Virus Following Systemic Chemotherapy in a Hepatitis B Surface Antigen-negative Patient with Colorectal Cancer Reviewed

    Yutaka Okagawa, Kohichi Takada, Hiroyuki Hisai, Yutaka Koshiba, Hironori Wada, Etsu Miyazaki, Yusuke Kanari, Yutaka Kawano, Satoshi Iyama, Tsuyoshi Hayashi, Tsutomu Sato, Yasushi Sato, Koji Miyanishi, Masayoshi Kobune, Rishu Takimoto, Junji Kato

    INTERNAL MEDICINE   53 ( 16 )   1759 - 1762   2014

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  • [Hematologic improvement with deferasirox following tandem antithymocyte globulin treatment in a transfusion-dependent patient with severe aplastic anemia]. Reviewed

    Jomen W, Kuroda H, Yamada M, Matsuno T, Sato M, Abe T, Sakurai T, Fujii S, Maeda M, Fujita M, Nagashima K, Iyama S, Miyanishi K, Kobune M, Kato J

    [Rinsho ketsueki] The Japanese journal of clinical hematology   54 ( 11 )   2047 - 2052   2013.11

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  • [Successful treatment with rituximab in a patient with refractory mixed-type autoimmune hemolytic anemia]. Reviewed

    Ono K, Sato T, Iyama S, Tatekoshi A, Hashimoto A, Kamihara Y, Horiguchi H, Kikuchi S, Takada K, Hayashi T, Miyanishi K, Sato Y, Takimoto R, Kobune M, Kato J

    [Rinsho ketsueki] The Japanese journal of clinical hematology   54   2053 - 2055   2013.11

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  • A case of hemosiderin deposition associated with hepatic graft-versus-host disease after peripheral blood stem cell transplantation for acute lymphocytic leukemia Reviewed

    Wataru Jomen, Hiroyuki Kuroda, Yohei Arihara, Michiko Yamada, Tasuku Hirako, Tomoyuki Abe, Tamaki Sakurai, Shigeyuki Fujii, Masahiro Maeda, Miri Fujita, Kazuo Nagashima, Satoshi Iyama, Koji Miyanishi, Masayoshi Kobune, Junji Kato

    Acta Hepatologica Japonica   54 ( 11 )   741 - 747   2013

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  • Stromal cells expressing hedgehog-interacting protein regulate the proliferation of myeloid neoplasms Reviewed

    M. Kobune, S. Iyama, S. Kikuchi, H. Horiguchi, T. Sato, K. Murase, Y. Kawano, K. Takada, K. Ono, Y. Kamihara, T. Hayashi, K. Miyanishi, Y. Sato, R. Takimoto, J. Kato

    BLOOD CANCER JOURNAL   2   2012.9

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    DOI： 10.1038/bcj.2012.36

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  • Intermittent administration of recombinant human soluble thrombomodulin successfully controlled chronic disseminated intravascular coagulation in a patient with dissecting aortic aneurysm on an outpatient basis Reviewed

    Satoshi Iyama, Tsutomu Sato, Kazuyuki Murase, Yusuke Kamihara, Kaoru Ono, Shohei Kikuchi, Kohichi Takada, Koji Miyanishi, Yasushi Sato, Rishu Takimoto, Masayoshi Kobune, Junji Kato

    BLOOD COAGULATION & FIBRINOLYSIS   23 ( 6 )   548 - 550   2012.9

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    DOI： 10.1097/MBC.0b013e32835510d6

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  • Improvement of iron-mediated oxidative DNA damage in patients with transfusion-dependent myelodysplastic syndrome by treatment with deferasirox Reviewed

    Shohei Kikuchi, Masayoshi Kobune, Satoshi Iyama, Tsutomu Sato, Kazuyuki Murase, Yutaka Kawano, Kohichi Takada, Kaoru Ono, Yumiko Kaneko, Koji Miyanishi, Yasushi Sato, Tsuyoshi Hayashi, Rishu Takimoto, Junji Kato

    FREE RADICAL BIOLOGY AND MEDICINE   53 ( 4 )   643 - 648   2012.8

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    DOI： 10.1016/j.freeradbiomed.2012.06.006

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  • Targeting Anticancer Drug Delivery to Pancreatic Cancer Cells Using a Fucose-Bound Nanoparticle Approach Reviewed

    Makoto Yoshida, Rishu Takimoto, Kazuyuki Murase, Yasushi Sato, Masahiro Hirakawa, Fumito Tamura, Tsutomu Sato, Satoshi Iyama, Takahiro Osuga, Koji Miyanishi, Kohichi Takada, Tsuyoshi Hayashi, Masayoshi Kobune, Junji Kato

    PLOS ONE   7 ( 7 )   e39545   2012.7

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  • Prognostic significance of serum ferritin level at diagnosis in myelodysplastic syndrome Reviewed

    Shohei Kikuchi, Masayoshi Kobune, Satoshi Iyama, Tsutomu Sato, Kazuyuki Murase, Yutaka Kawano, Kohichi Takada, Kaoru Ono, Tsuyoshi Hayashi, Koji Miyanishi, Yasushi Sato, Rishu Takimoto, Junji Kato

    INTERNATIONAL JOURNAL OF HEMATOLOGY   95 ( 5 )   527 - 534   2012.5

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    DOI： 10.1007/s12185-012-1048-3

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  • Successful Treatment by Fibrin Glue Sealant for Pneumothorax with Chronic GVHD Resistant to Autologous Blood Patch Pleurodesis Reviewed

    Satoshi Iyama, Tsutomu Sato, Kazuyuki Murase, Shohei Kikuchi, Yusuke Kamihara, Kaoru Ono, Kohichi Takada, Koji Miyanishi, Yasushi Sato, Rishu Takimoto, Masayoshi Kobune, Takuro Obama, Masahiro Miyajima, Atsushi Watanabe, Tetsuya Higami, Yasuo Hirayama, Junji Kato

    INTERNAL MEDICINE   51 ( 15 )   2011 - 2014   2012

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    DOI： 10.2169/internalmedicine.51.7355

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  • Complete response by rituximab monotherapy in a patient with leukemic mantle cell lymphoma diagnosed by fluorescence in situ hybridization analysis Reviewed

    Yutaka Okagawa, Hiroyuki Kuroda, Kazuma Ishikawa, Michiko Yamada, Toshifumi Hoki, Tomoyuki Abe, Tamaki Sakurai, Shigeyuki Fujii, Masahiro Maeda, Miri Fujita, Wataru Jyomen, Satoshi Iyama, Junji Kato

    Japanese Journal of Cancer and Chemotherapy   39 ( 10 )   1547 - 1550   2012

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  • T-cell large granular lymphocyte leukemia after autologous peripheral blood stem cell transplantation for malignant lymphoma - Report of three cases and a review of the literature Reviewed

    Hiroyuki Kuroda, Tamaki Sakurai, Michiko Yamada, Tomoyuki Abe, Shigeyuki Fujii, Masahiro Maeda, Kyuhei Kohda, Yasuo Hirayama, Wataru Jyomen, Naoki Uemura, Michihiro Ono, Yuko Fujimi, Satoshi Iyama, Tsutomu Sato, Junji Kato

    Japanese Journal of Cancer and Chemotherapy   38 ( 10 )   1727 - 1732   2011.10

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  • A case of ulcerative colitis accompanied with myelodysplastic syndrome successfully treated by cyclosporine Reviewed

    Sho Takahashi, Yasushi Sato, Tamotsu Sagawa, Shingo Tanaka, Kazuyuki Murase, Kohichi Takada, Satoshi Iyama, Tsutomu Sato, Rishu Takimoto, Masayoshi Kobune, Ganji Kuroiwa, Michiaki Hirayama, Tetsuro Okamoto, Junji Kato

    Journal of Japanese Society of Gastroenterology   108 ( 8 )   1405 - 1412   2011.8

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    DOI： 10.11405/nisshoshi.108.1405

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  • Novel missense mutation in the TMPRSS6 gene in a Japanese female with iron-refractory iron deficiency anemia Reviewed

    Tsutomu Sato, Satoshi Iyama, Kazuyuki Murase, Yusuke Kamihara, Kaoru Ono, Shohei Kikuchi, Kohichi Takada, Koji Miyanishi, Yasushi Sato, Rishu Takimoto, Masayoshi Kobune, Junji Kato

    INTERNATIONAL JOURNAL OF HEMATOLOGY   94 ( 1 )   101 - 103   2011.7

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    DOI： 10.1007/s12185-011-0881-0

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  • Iron chelator deferasirox rescued mice from Fas-induced fulminant hepatitis Reviewed

    Tsutomu Sato, Masayoshi Kobune, Kazuyuki Murase, Yukari Kado, Tetsuro Okamoto, Shingo Tanaka, Shohei Kikuchi, Hiroyuki Nagashima, Yutaka Kawano, Kohichi Takada, Satoshi Iyama, Koji Miyanishi, Yasushi Sato, Rishu Takimoto, Junji Kato

    HEPATOLOGY RESEARCH   41 ( 7 )   660 - 667   2011.7

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    DOI： 10.1111/j.1872-034X.2011.00821.x

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  • Establishment of a simple test for iron absorption from the gastrointestinal tract Reviewed

    Masayoshi Kobune, Koji Miyanishi, Kohichi Takada, Yutaka Kawano, Hiroyuki Nagashima, Shohei Kikuchi, Kazuyuki Murase, Satoshi Iyama, Tsutomu Sato, Yasushi Sato, Rishu Takimoto, Junji Kato

    INTERNATIONAL JOURNAL OF HEMATOLOGY   93 ( 6 )   715 - 719   2011.6

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    DOI： 10.1007/s12185-011-0878-8

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  • Tuberculous pleuritis with onset of refractory pleural effusion after chemoradiotherapy for esophageal cancer Reviewed

    Masahiro Hirakawa, Yasushi Sato, Hiroyuki Ohnuma, Tamotsu Sagawa, Hirotoshi Ishiwatari, Kazuyuki Murase, Satoshi Iyama, Tsuyoshi Hayashi, Tsutomu Sato, Koji Miyanishi, Masayoshi Kobune, Rishu Takimoto, Junji Kato

    Journal of Japanese Society of Gastroenterology   108 ( 2 )   231 - 237   2011.2

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    DOI： 10.11405/nisshoshi.108.231

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  • Immune thrombocytopenia associated with de novo hepatitis B in a follicular lymphoma patient after autologous peripheral blood stem cell transplantation

    Hiroyuki Kuroda, Tamaki Sakurai, Michiko Yamada, Naoki Uemura, Michihiro Ono, Tomoyuki Abe, Shigeyuki Fujii, Masahiro Maeda, Kyuhei Kohda, Yasuo Hirayama, Yuko Fujimi, Satoshi Iyama, Junji Kato

    Biotherapy   25 ( 1 )   579 - 583   2011.1

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  • Effective treatment by both anti-androgen therapy and chemotherapy for a patient with advanced salivary duct carcinoma Reviewed

    Hiroyuki Kuroda, Tamaki Sakurai, Michiko Yamada, Naoki Uemura, Michihiro Ono, Tomoyuki Abe, Shigeyuki Fujii, Masahiro Maeda, Kyuhei Kohda, Masahiko Obata, Masakatsu Ando, Satoshi Iyama, Junji Kato

    Japanese Journal of Cancer and Chemotherapy   38 ( 4 )   627 - 630   2011

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  • Successful rituximab treatment of methotrexate-associated B-cell lymphoproliferative disorder arising in two patients with latency type II epstein-barr viral infection

    Hiroyuki Kuroda, Tamaki Sakurai, Michiko Yamada, Naoki Uemura, Michihiro Ono, Tomoyuki Abe, Shigeyuki Fujii, Masahiro Maeda, Nanase Ishida, Kyuhei Kohda, Masahiko Obata, Masakatsu Ando, Satoshi Iyama, Junji Kato

    Biotherapy   24 ( 6 )   507 - 511   2010.11

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  • ENDOSCOPIC FINDINGS OF ENTEROPATHY-TYPE T-CELL LYMPHOMA BY DOUBLE-BALLOON ENTEROSCOPY AND CAPSULE ENDOSCOPY Reviewed

    Yasushi Sato, Michihiro Ono, Tamotsu Sagawa, Rishu Takimoto, Masahiro Hirakawa, Hiroyuki Ohnuma, Tsutomu Sato, Satoshi Iyama, Kazuyuki Murase, Koji Miyanishi, Masayoshi Kobune, Junji Kato

    DIGESTIVE ENDOSCOPY   22 ( 3 )   243 - 245   2010.7

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  • [Evaluation of the efficacy of liposomal amphotericin B]. Reviewed

    Iyama S, Murase K, Sato T, Kikuchi S, Sato Y, Kobune M, Takimoto R, Kato J

    Kansenshogaku zasshi. The Journal of the Japanese Association for Infectious Diseases   84 ( 2 )   182 - 186   2010.3

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    A retrospective study was performed to evaluate the efficacy and safety of liposomal amphotericin B (L-AMB) in a total of 32 cases who were among patients hospitalized at the Fourth Department of Internal Medicine, Sapooro Medical University from December 2006 to April 2008. Primary diagnoses were hematologic diseases in 87.5％of subjects. The most common hematologic diseases included acute myelogenous leukemia in 50％of the subjects, followed by malignant lymphoma in 12.5％of the subjects. The mean administration period was 14.2±12.9 days, and the mean cumulative dose was 1,786±2,181 mg. L-AMB improved 21 of 29 cases (72.4％) with some fungal infections or fever-associated neutropenia. Adverse events occurred in 9 cases to a slight degree, in 7 cases to a moderate degree, and in no case to a severe degree. Hypokalemia and hypercreatininemia were seen in 7 cases (21.9％) and 4 cases (12.5％), respectively, but these adverse reactions were so mild that the treatment did not need to be discontinued. Any adverse reactions for which treatment administration was discontinued were confirmed to have disappeared at the end of the study. These results support the efficacy and safety of L-AMB in accordance with previous foreign reports. It was noteworthy that early use of L-AMB prior to established diagnosis sometimes better therapeutic outcomes. It was also suggested that L-AMB could be safely administered while controlling electrolyte balance, such as serum potassium concentration, with sufficient fluid replacement, including physiological saline infusion. There are limitations in the use of the conventional form of amphotericin B because of its renal toxicity and other reasons. However, L-AMB had fewer side effects, so the agent was considered useful for the treatment of hematologic disease patients who either had mycosis or carried a risk for fungal infection.

    Other Link： http://search.jamas.or.jp/link/ui/2010172514

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  • Pure Red Cell Aplasia Associated with Good&apos;s Syndrome Accompanied by Decreased Stem Cell Factor Production in the Bone Marrow Reviewed

    Kageaki Kuribayashi, Akihito Fujimi, Masayoshi Kobune, Rishu Takimoto, Shohei Kikuchi, Satoshi Iyama, Junji Kato, Yoshiro Niitsu, Naoki Watanabe

    INTERNAL MEDICINE   49 ( 5 )   377 - 382   2010

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    DOI： 10.2169/internalmedicine.49.2811

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  • Therapeutic results in patients with biphenotypic acute leukemia at Sapporo Medical University Hospital Reviewed

    Kazuyuki Murase, Satoshi Iyama, Tsutomu Sato, Rishu Takimoto, Masayoshi Kobune, Junji Kato

    Japanese Journal of Cancer and Chemotherapy   37 ( 10 )   2011 - 2013   2010

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  • ヘッジホッグ・シグナル伝達阻害剤は、CD34+白血病細胞の薬剤耐性を解除する Reviewed

    菊地 尚平, 小船 雅義, 村瀬 和幸, 井山 諭, 佐藤 勉, 瀧本 理修, 河野 豊, 宮西 浩嗣, 佐藤 康史, 加藤 淳二

    臨床血液   50 ( 9 )   1113 - 1113   2009.9

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  • シクロパミンは、CD34陽性白血病細胞の薬剤耐性を解除する(Cyclopamine dramatically restores drug resistance of CD34+ leukemic cells) Reviewed

    小船 雅義, 井山 諭, 佐藤 勉, 瀧本 理修, 菊地 尚平, 村瀬 和幸, 河野 豊, 宮西 浩嗣, 佐藤 康史, 加藤 淳二

    日本癌学会総会記事   68回   480 - 480   2009.8

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  • [Successful induction of complete remission by gemtuzumab ozogamicin following chemotherapy in three patients with relapsed or refractory acute myeloid leukemia]. Reviewed

    Hirayama Y, Terui T, Koike K, Neda H, Ishitani K, Kohda K, Kuroda H, Iyama S, Sato T, Kobune M, Takimoto R, Kato J

    [Rinsho ketsueki] The Japanese journal of clinical hematology   50 ( 8 )   663 - 665   2009.8

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  • Drug resistance is dramatically restored by hedgehog inhibitors in CD34(+) leukemic cells Reviewed

    Masayoshi Kobune, Rishu Takimoto, Kazuyuki Murase, Satoshi Iyama, Tsutomu Sato, Shohei Kikuchi, Yutaka Kawano, Kohji Miyanishi, Yasushi Sato, Yoshiro Niitsu, Junji Kato

    CANCER SCIENCE   100 ( 5 )   948 - 955   2009.5

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  • Chronic idiopathic neutropenia associated with granular lymphocytic leukemia effectively treated with immunosuppressants

    Yuko Fujimi, Yasuo Hirayama, Hiroyuki Kuroda, Toshiro Sakai, Yuichi Konuma, Kyuhei Kohda, Akihito Fujimi, Satoshi Iyama, Tsutomu Sato, Masayoshi Kobune, Rishu Takimoto, Junji Kato

    Biotherapy   23 ( 3 )   263 - 266   2009.5

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  • アデノウイルスベクターを用いたヘッジホッグ遺伝子の高発現は、TおよびBリンパ球の分化抑制を誘導する Reviewed

    加藤 淳二, 小船 雅義, 村瀬 和幸, 井山 諭, 佐藤 勉, 河野 豊, 瀧本 理修, 松永 卓也

    臨床血液   49 ( 9 )   1085 - 1085   2008.9

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  • ヒト骨髄間質細胞は臍帯血CD34陰性細胞のCXCR4発現増強と長期造血再建能を誘導する Reviewed

    小船 雅義, 村瀬 和幸, 井山 諭, 佐藤 勉, 河野 豊, 瀧本 理修, 松永 卓也, 加藤 淳二

    臨床血液   49 ( 9 )   940 - 940   2008.9

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  • Treatment of hepatocellular carcinoma by AdAFPep/Rep, AdAFPep/p53, and 5-fluorouracil in mice Reviewed

    Tamotsu Sagawa, Yasuyuki Yamada, Minoru Takahashi, Yasushi Sato, Masayoshi Kobune, Rishu Takimoto, Junki Fukaura, Satoshi Iyama, Tsutomu Sato, Koji Miyanishi, Takuya Matsunaga, Tetsuji Takayama, Junji Kato, Katsunori Sasaki, Hirofumi Hamada, Yoshiro Niitsu

    HEPATOLOGY   48 ( 3 )   828 - 840   2008.9

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    DOI： 10.1002/hep.22420

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  • [A case of hepatosplenic gammadelta T-cell lymphoma associated hemophagocytic syndrome]. Reviewed

    Iyama S, Matsunaga T, Sato T, Sato Y, Sagawa T, Murase K, Kida M, Kobune M, Takimoto R, Kato J, Niitsu Y

    Gan to kagaku ryoho. Cancer & chemotherapy   35   1623 - 1627   2008.9

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  • Apoptosis supercedes necrosis in mitochondrial DNA-depleted Jurkat cells by cleavage of receptor-interacting protein and inhibition of lysosomal cathepsin Reviewed

    Tsutomu Sato, Takuro Machida, Sho Takahashi, Kazuyuki Murase, Yutaka Kawano, Tsuyoshi Hayashi, Satoshi Iyama, Kohich Takada, Kageaki Kuribayashi, Yasushi Sato, Masayoshi Kobune, Rishu Takimoto, Takuya Matsunaga, Junji Kato, Yoshiro Niitsu

    JOURNAL OF IMMUNOLOGY   181 ( 1 )   197 - 207   2008.7

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  • Ex vivo large-scale generation of human red blood cells from cord blood CD34(+) cells by co-culturing with macrophages Reviewed

    Akihito Fujimi, Takuya Matsunaga, Masayoshi Kobune, Yutaka Kawano, Taiko Nagaya, Ikuta Tanaka, Satoshi Iyama, Tsuyoshi Hayashi, Tsutomu Sato, Koji Miyanishi, Tamotsu Sagawa, Yasushi Sato, Rishu Takimoto, Tetsuji Takayama, Junji Kato, Shinsei Gasa, Hiromi Sakai, Eishun Tsuchida, Kenji Ikebuchi, Hirofumi Hamada, Yoshiro Niitsu

    INTERNATIONAL JOURNAL OF HEMATOLOGY   87 ( 4 )   339 - 350   2008.5

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    DOI： 10.1007/s12185-008-0062-y

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  • [An advanced metastatic breast cancer patient successfully treated with combination therapy including docetaxel, doxorubicin and cyclophosphamide (TAC) as salvage therapy]. Reviewed

    Sato Y, Takayama T, Sagawa T, Sato T, Okamoto K, Takahashi S, Abe S, Iyama S, Murase K, Kato J, Niitsu Y

    Gan to kagaku ryoho. Cancer & chemotherapy   35   471 - 473   2008.3

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  • Successful treatment of chronic myeloproliferative disease-unclassifiable (CMPD-U) with no chromosomal abnormalities by imatinib mesylate Reviewed

    Satoshi Iyama, Takuya Matsunaga, Tsutomu Sato, Kazuyuki Murase, Naoko Araki, Rishu Takimoto, Masayoshi Kobune, Tamotsu Sagawa, Tetsuji Takayama, Yoshiro Niitsu

    INTERNAL MEDICINE   47 ( 8 )   791 - 794   2008

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    DOI： 10.2169/internalmedicine.47.0714

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  • Successful treatment of autoimmune pancreatitis complicated with autoimmune thrombocytopenia and interstitial pneumonia by prednisolone Reviewed

    Kazuyuki Murase, Takuya Matsunaga, Tsuyoshi Hayashi, Hirotoshi Ishiwatari, Naoko Araki, Satoshi Iyama, Tsutomu Sato, Masayoshi Kobune, Rishu Takimoto, Koji Miyanishi, Toru Miyazaki, Hisami Ikeda, Junji Kato, Yoshiro Niitsu

    INTERNAL MEDICINE   47 ( 11 )   1033 - 1038   2008

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    DOI： 10.2169/internalmedicine.47.0803

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  • [A case of resection of synchronous multiple liver metastases from colorectal cancer after hepatic infusion chemotherapy and systemic chemotherapy]. Reviewed

    Tamotsu Sagawa, Yasushi Sato, Tetsuji Takayama, Masahiro Hirakawa, Seiichiro Abe, Satoshi Iyama, Koji Miyanishi, Yutaka Kawano, Kohichi Takada, Tokiko Nakamura, Junji Kato, Yoshiro Niitsu

    Gan to kagaku ryoho. Cancer & chemotherapy   34 ( 9 )   1481 - 4   2007.9

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    A 70-year-old man was admitted for tranverse colon cancer with multiple liver metastases. Hepatic arterial infusion chemotherapy and systemic chemotherapy (FOLFOX 4) were conducted postoperatively. Thirteen months after the first surgery, liver metastases became resectable and hepatectomy was performed. Though multiple liver metastases were unresectable at the time of the first examination, hepatectomy was possible followed by hepatic arterial infusion chemotherapy and systemic chemotherapy.

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  • 骨髄腫から産生されるWnt3は、RhoAシグナルを活性化し、VLA6依存性CAM-DRを惹起する Reviewed

    小船 雅義, 河野 豊, 村瀬 和幸, 井山 諭, 佐藤 勉, 瀧本 理修, 松永 卓也, 加藤 淳二, 新津 洋司郎

    日本癌治療学会誌   42 ( 2 )   482 - 482   2007.9

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  • 肝動注療法および全身化学療法にて切除可能となった大腸癌肝転移の1例 Reviewed

    佐川 保, 佐藤 康史, 高山 哲治, 平川 昌宏, 阿部 清一郎, 井山 諭, 宮西 浩嗣, 河野 豊, 高田 弘一, 中村 とき子, 加藤 淳二, 新津 洋司郎

    癌と化学療法   34 ( 9 )   1481 - 1484   2007.9

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  • [Fifth-line chemotherapy for metastatic gastric cancer--a case responding to modified FOLFOX 6]. Reviewed

    Sagawa T, Sato Y, Takayama T, Kuroda H, Hirakawa M, Abe S, Iyama S, Sakamaki S, Kato J, Niitsu Y

    Gan to kagaku ryoho. Cancer & chemotherapy   34   1467 - 1471   2007.9

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  • [Reactivation of hepatitis B virus due to rituximab plus CHOP after preemptive lamivudine administration in a patient with diffuse large B-cell lymphoma]. Reviewed

    Kaoru Ono, Satoshi Iyama, Takuya Matsunaga, Tsutomu Sato, Yasushi Sato, Toshinori Okuda, Kohichi Takada, Yutaka Kawano, Tsuyoshi Hayashi, Koji Miyanishi, Tamotsu Sagawa, Masayoshi Kobune, Rishu Takimoto, Junji Kato, Yoshiro Niitsu

    Gan to kagaku ryoho. Cancer & chemotherapy   34 ( 9 )   1509 - 12   2007.9

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    A 59-year-old woman received eight cycles of R-CHOP for diffuse large B-cell lymphoma from July, 2004. Pretreatment HBV serological tests were positive, however, the transaminases were within normal limits, and she remained asymptomatic. Lamivudine (LAM) was administered orally from the start of R-CHOP. HBV-DNA levels gradually decreased and were not detected until December, 2004. LAM was administered until 3 months after the end of chemotherapy, with the entire treatment lasting less than 1 year. Two months after the cessation of treatment, she was re-admitted for general malaise. A liver function test revealed severe abnormalities, and HBVDNA levels were increased. Clinically, she was experiencing acute hepatitis due to HBV reactivation. She was then treated with LAM and interferon-beta immediately. Her HBV-DNA levels soon decreased, and liver function improved.

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  • Wnt3/RhoA/ROCKシグナル伝達は多発性骨髄腫の接着介在性薬物耐性へと自己分泌性に関与する(Wnt3/RhoA/ROCK signaling is involved in adhesion-mediated drug resistance of multiple myeloma in an autocline manner) Reviewed

    小船 雅義, 井山 諭, 佐藤 勉, 瀧本 理修, 松永 卓也, 河野 豊, 村瀬 和幸, 加藤 淳二, 新津 洋司郎

    日本癌学会総会記事   66回   334 - 334   2007.8

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  • [Superior mesenteric and portal vein thrombosis in a polycythemia vera patient with JAK2 mutation]. Reviewed

    Naoko Araki, Rishu Takimoto, Hiroki Chiba, Hironobu Araki, Tsutomu Sato, Satoshi Iyama, Masahiro Hirakawa, Kaoru Ono, Yutaka Kawano, Koichi Takada, Koji Miyanishi, Masayoshi Kobune, Takuya Matsunaga, Junji Kato, Tokiko Nakamura, Yoshiro Niitsu

    [Rinsho ketsueki] The Japanese journal of clinical hematology   48 ( 7 )   554 - 8   2007.7

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    A 47-year-old woman was admitted to our hospital in December 1994 with polycythemia. The patient's red blood cell volume was 33 ml/kg and bone marrow cytology was able to rule out other myeloproliferative diseases such as chronic myelogenous leukemia, essential thrombocytosis and myelofibrosis. The patient was diagnosed as having polycythemia vera. She had undergone only phlebotomy until 1999 when the thrombocytosis appeared, subsequent to which she was treated with oral hydroxyurea. However, in March 2006, she developed upper abdominal pain and was admitted to our hospital on March 14th, 2006. Computed tomography scan revealed thromboses in the portal and superior mesenteric veins. Anticoagulation therapy delivered intravenously via the superior mesenteric vein dramatically improved her symptoms and liver function. She is currently on anticoagulation therapy in our outpatient clinic.

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  • [Factor XI deficiency caused by a mutation of Gly400Val]. Reviewed

    Sato T, Iyama S, Araki N, Murase K, Sato Y, Kobune M, Takimoto R, Matsunaga T, Kato J, Kuroda H, Niitsu Y

    [Rinsho ketsueki] The Japanese journal of clinical hematology   48 ( 2 )   148 - 150   2007.2

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    DOI： 10.11406/rinketsu.48.148

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  • [Gastric relapse of stage I ocular adnexal mucosa-associated lymphoid tissue lymphoma]. Reviewed

    Sato T, Takimoto R, Iyama S, Ono K, Tanaka S, Araki N, Nishiie K, Murase K, Sato Y, Kobune M, Matsunaga T, Kato J, Niitsu Y

    [Rinsho ketsueki] The Japanese journal of clinical hematology   48 ( 1 )   56 - 60   2007.1

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    A 57-year-old male with right ocular adnexal mucosa-associated lymphoid tissue lymphoma (MALT lymphoma) was successfully treated with local radiation therapy. The gastroendoscopic examination revealed a slight inflammatory change of the gastric mucosa, and the urease test was positive. Eradication therapy against <i>Helicobacter pylori</i> was successfully done, however, the patient developed gastric MALT lymphoma two years after the initial treatment. Southern blot analysis of the immunoglobulin heavy chain gene rearrangement revealed that the lymphoma cells from the ocular adnexal and gastric MALT lymphomas were identical, indicating that the gastric MALT lymphoma was not the primary but the metastatic region from the ocular adnexal MALT lymphoma. Further, immunohistochemical staining demonstrated the expression of integrin &alpha;4&beta;7 on ocular adnexal MALT lymphoma cells, which is essential for the adhesion of lymphocytes to gastrointestinal mucosa. These results indicate that ocular adnexal MALT lymphoma cells can metastasize to the stomach, depending on the adhesional function of integrin &alpha;4&beta;7.

    Other Link： http://search.jamas.or.jp/link/ui/2007162208

    DOI： 10.11406/rinketsu.48.56

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  • Report of an autopsy case of colon cancer with amyotrophic lateral sclerosis Reviewed

    Yasushi Sato, Tetsuji Takayama, Tomomi Nikaido, Yuko Wada, Tamotsu Sagawa, Seiichiro Abe, Tsutomu Sato, Satoshi Iyama, Kazuyuki Murase, Hironobu Araki, Yasuhiro Sato, Junji Kato, Yoshiro Niitsu, Hideki Chiba

    Japanese Journal of Gastroenterology   104 ( 9 )   1365 - 1370   2007

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    DOI： 10.11405/nisshoshi.104.1365

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  • Ex vivo large-scale generation of human platelets from cord blood CD34(+) cells Reviewed

    Takuya Matsunaga, Ikuta Tanaka, Masayoshi Kobune, Yutaka Kawano, Maki Tanaka, Kageaki Kuribayashi, Satoshi Iyama, Tsutomu Sato, Yasushi Sato, Rishu Takimoto, Tetsuji Takayama, Junji Kato, Takafumi Ninomiya, Hirofumi Hamada, Yoshiro Niitsu

    STEM CELLS   24 ( 12 )   2877 - 2887   2006.12

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    DOI： 10.1634/stemcells.2006-0309

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  • A phase I/II study of nedaplatin and 5-fluorouracil with concurrent radiotherapy in patients with esophageal cancer Reviewed

    Yasushi Sato, Tetsuji Takayama, Tamotsu Sagawa, Tetsuro Okamoto, Koji Miyanishi, Tsutomu Sato, Hironobu Araki, Satoshi Iyama, Seiichiro Abe, Kazuyuki Murase, Rishu Takimoto, Hisayasu Nagakura, Masato Hareyama, Junji Kato, Yoshiro Niitsu

    CANCER CHEMOTHERAPY AND PHARMACOLOGY   58 ( 5 )   570 - 576   2006.11

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    DOI： 10.1007/s00280-006-0193-x

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  • [Peripheral T-cell lymphoma presenting with eosinophilia due to interleukin-5 produced by lymphoma cells]. Reviewed

    Matsunaga T, Sato T, Iyama S, Tanaka S, Murase K, Sato Y, Kobune M, Takimoto R, Kato J, Kuroda H, Niitsu Y

    [Rinsho ketsueki] The Japanese journal of clinical hematology   47 ( 11 )   1457 - 1462   2006.11

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    A 72-year-old male was admitted to our hospital to determine the cause of neck lymphadenopathies. He was diagnosed pathologically by a lymph node biopsy as having peripheral T-cell lymphoma (PTCL). He also had developed eosinophilia and his serum concentration of Interleukin-5 (IL-5) was extremely high. Immunostaining of a resected lymph node revealed that there were lymphoma cells which were stained with anti-IL-5 antibody. After 2 courses of CHOP therapy, the lymphadenopathies and eosinophilia disappeared and the concentration of serum IL-5 was normalized. It was suggested that IL-5 produced by lymphoma cells had induced his eosinophilia.

    Other Link： https://jlc.jst.go.jp/DN/JALC/00288263616?from=CiNii

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  • A case of recurrent biliary cystadenocarcinoma successfully treated with 5FU/CDDP systemic chemotherapy Reviewed

    Satoshi Iyama, Yasuo Takahashi, Naoaki Shintani, Koshi Fujikawa, Syunichi Ohkubo, Yasushi Sato, Tsutomu Sato, Yasuhiro Sato, Keisuke Ohnuma, Yoshiro Niitsu

    Japanese Journal of Gastroenterology   103 ( 10 )   1163 - 1168   2006.10

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  • ヒトTERT-stroma細胞を用いた末梢血CD133陽性細胞のex vivo増幅系の確立 Reviewed

    小船 雅義, 河野 豊, 千葉 大樹, 井山 諭, 佐藤 勉, 瀧本 理修, 松永 卓也, 加藤 淳二, 濱田 洋文, 新津 洋司郎

    臨床血液   47 ( 9 )   1151 - 1151   2006.9

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  • [Enteropathy-type T-cell lymphoma with CD8 and CD56 expression]. Reviewed

    Sato T, Matsunaga T, Iyama S, Sakai T, Murase K, Sato Y, Kobune M, Takimoto R, Kato J, Niitsu Y

    [Rinsho ketsueki] The Japanese journal of clinical hematology   47   645 - 649   2006.7

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  • [De novo CD5-positive diffuse large B-cell lymphoma associated with autoimmune hemolytic anemia presenting as erythroid hypoplasia]. Reviewed

    Kuroda H, Matsunaga T, Iyama S, Takimoto R, Shirao S, Kida M, Watanabe H, Konuma Y, Hirayama Y, Kohda K, Niitsu Y

    [Rinsho ketsueki] The Japanese journal of clinical hematology   47 ( 7 )   633 - 638   2006.7

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  • Amelioration of murine dextran sulfate sodium-induced colitis by ex vivo extracellular superoxide dismutase gene transfer Reviewed

    Takatomi Oku, Satoshi Iyama, Tsutomu Sato, Yasushi Sato, Maki Tanaka, Tamotsu Sagawa, Kageaki Kuribayashi, Tetsuya Sumiyoshi, Kazuyuki Murase, Takuro Machida, Tetsuro Okamoto, Takuya Matsunaga, Tetsuji Takayama, Minoru Takahashi, Junji Kato, Hirofumi Hamada, Yoshiro Niitsu

    INFLAMMATORY BOWEL DISEASES   12 ( 7 )   630 - 640   2006.7

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    DOI： 10.1097/01.MIB.0000225335.68614.73

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  • Human herpesvirus-6 hepatitis associated with cyclosporine-A encephalitis after bone marrow transplantation for chronic myeloid leukemia Reviewed

    Kageaki Kuribayashi, Takuya Matsunaga, Satoshi Iyama, Koichi Takada, Tsutomu Sato, Kazuyuki Murase, Akihito Fujimi, Rishu Takimoto, Johji Kawanishi, Yoshiro Niitsu

    INTERNAL MEDICINE   45 ( 7 )   475 - 478   2006

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    DOI： 10.2169/internalmedicine.45.1507

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  • [Essential thrombocythemia associated with incomplete type intestinal Behçet disease during hydroxyurea treatment]. Reviewed

    Kobune M, Kato J, Kuribayashi K, Iyama S, Fujimi A, Murase K, Ueno A, Kikuchi S, Satoh T, Okamoto T, Takimoto R, Matsunaga T, Niitsu Y

    [Rinsho ketsueki] The Japanese journal of clinical hematology   46 ( 10 )   1136 - 1140   2005.10

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  • [Two cases of primary skeletal muscle lymphoma, and a review of the literature]. Reviewed

    Ueno A, Kuribayashi K, Iyama S, Matsunaga T, Kikuchi S, Sato T, Kobune M, Takimoto R, Kato J, Niitsu Y

    [Rinsho ketsueki] The Japanese journal of clinical hematology   46   1141 - 1145   2005.10

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  • Donor cell derived acute myeloid leukemia after allogeneic cord blood transplantation in a patient with adult T-cell lymphoma Reviewed

    T Matsunaga, K Murase, M Yoshida, A Fujimi, S Iyama, K Kuribayashi, T Sato, K Kogawa, Y Hirayama, S Sakamaki, K Kohda, Y Niitsu

    AMERICAN JOURNAL OF HEMATOLOGY   79 ( 4 )   294 - 298   2005.8

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    DOI： 10.1002/ajh.20349

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  • Human mesenchymal stem cells xenografted directly to rat liver are differentiated into human hepatocytes without fusion Reviewed

    Y Sato, H Araki, J Kato, K Nakamura, Y Kawano, M Kobune, T Sato, K Miyanishi, T Takayama, M Takahashi, R Takimoto, S Iyama, T Matsunaga, S Ohtani, A Matsuura, H Hamada, Y Niitsu

    BLOOD   106 ( 2 )   756 - 763   2005.7

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    DOI： 10.1182/blood-2005-02-0572

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  • [Successful treatment with oral ribavirin of adenovirus-associated hemophagocytic syndrome in a stem cell transplantation recipient]. Reviewed

    Iyama S, Matsunaga T, Fujimi A, Murase K, Kuribayasi K, Sato T, Hirayama Y, Sakamaki S, Kohda K, Niitsu Y

    [Rinsho ketsueki] The Japanese journal of clinical hematology   46 ( 5 )   363 - 367   2005.5

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    A 51-year-old woman with severe aplastic anemia underwent allogeneic peripheral blood stem cell transplantation using blood stem cells from an HLA-identical sibling. Adenovirus type 11 hemorrhagic cystitis developed and progressed to nephritis and hemophagocytic syndrome. Oral ribavirin was effective not only for the hemorrhagic cystitis and nephritis but also for the hemophagocytic syndrome. Since therapeutic strategies for adenovirus infection after hematopoietic stem cell transplantation have not been established, we present our case and discuss the therapeutic approach.

    Other Link： https://jlc.jst.go.jp/DN/JALC/00252353084?from=CiNii

    DOI： 10.11406/rinketsu.46.363

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  • Prolonged survival of mice with multiple liver metastases of human colon cancer by intravenous administration of replicable E1B-55K-deleted adenovirus with E1A expressed by CEA promoter Reviewed

    T Sagawa, M Takahashi, T Sato, Y Sato, Y Lu, T Sumiyoshi, Y Yamada, S Iyama, J Fukaura, K Sasaki, H Hamada, K Miyanishi, T Takayama, J Kato, Y Niitsu

    MOLECULAR THERAPY   10 ( 6 )   1043 - 1050   2004.12

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    DOI： 10.1016/j.ymthe.2004.08.023

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  • 遺伝子治療 AFP産生肝癌に対する制限増殖型アデノウイルス,p53遺伝子,5-FUの3者併用は高い抗腫瘍効果を示す

    山田 康之, 高橋 稔, 佐川 保, 佐藤 康史, 佐藤 勉, 深浦 純生, 井山 諭, 佐々木 勝則, 中村 公則, 濱田 洋文, 新津 洋司郎

    日本癌治療学会誌   39 ( 2 )   397 - 397   2004.9

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  • Interleukin-11 as an osteoprotegerin-inducing factor in culture medium of blastic cells from a patient with acute megakaryocytic leukemia complicated with osteosclerosis Reviewed

    T Sato, T Matsunaga, M Kida, K Morii, T Machida, Y Kawano, K Nakamura, K Kuribayashi, K Takada, S Iyama, Y Sato, T Takayama, M Takahashi, J Kato, M Chokki, Y Niitsu

    AMERICAN JOURNAL OF HEMATOLOGY   77 ( 1 )   62 - 66   2004.9

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    DOI： 10.1002/ajh.20141

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  • Fas-mediated apoptosome formation is dependent on reactive oxygen species derived from mitochondrial permeability transition in Jurkat cells Reviewed

    T Sato, T Machida, S Takahashi, S Iyama, Y Sato, K Kuribayashi, K Takada, T Oku, Y Kawano, T Okamoto, R Takimoto, T Matsunaga, T Takayama, M Takahashi, J Kato, Y Niitsu

    JOURNAL OF IMMUNOLOGY   173 ( 1 )   285 - 296   2004.7

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  • [A case of gastric carcinoma with multiple skin, bone, and bilateral ovary metastasis; effective treatment by chemotherapy]. Reviewed

    Mezawa S, Homma H, Doi T, Akiyama T, Murakami K, Kogawa K, Hirata K, Kida M, Murase K, Iyama S

    Gan to kagaku ryoho. Cancer & chemotherapy   30   1973 - 1975   2003.11

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  • [A case responding to weekly paclitaxel (TXL) therapy as third line chemotherapy for scirrhous type gastric cancer]. Reviewed

    Sagawa T, Tsuji Y, Takayanagi N, Hirayama Y, Sakamaki S, Chiba H, Nakajima T, Iyama S, Oku T, Sumiyoshi T, Sato Y, Takahashi M, Takayama T, Niitsu Y

    Gan to kagaku ryoho. Cancer & chemotherapy   30   707 - 710   2003.5

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  • Superselective transcatheter embolization for acute lower gastrointestinal hemorrhage after endoscopic mucosal resection: A report of 3 cases Reviewed

    S Mezawa, H Homma, K Murase, T Doi, S Iyama, K Takada, K Hirata, F Mezawa, Y Niitsu

    HEPATO-GASTROENTEROLOGY   50 ( 51 )   735 - 737   2003.5

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  • [A case of irinotecan-resistant colon cancer responding to chronotherapy with oxaliplatin, 5-FU, l-LV]. Reviewed

    Sagawa T, Tsuji Y, Takayanagi N, Hirayama Y, Sakamaki S, Chiba H, Iyama S, Oku T, Sato Y, Takahashi M, Takayama T, Niitsu Y

    Gan to kagaku ryoho. Cancer & chemotherapy   30   537 - 543   2003.4

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  • 肝腫瘍に対する食塩水注入併用ラジオ波凝固療法による播種の危険性

    太田 英敏, 新谷 直昭, 高橋 康雄, 藤川 幸司, 井山 諭, 中村 とき子

    肝臓   43 ( 12 )   583 - 583   2002.12

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    DOI： 10.2957/kanzo.43.583

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  • [Usefulness of CT arteriography for transcatheter peripancreatic arterial embolization to patients with advanced pancreatic cancer]. Reviewed

    Doi T, Homma H, Mezawa S, Akiyama T, Machida T, Murakami K, Hirata K, Takanashi N, Iyama S, Niitsu Y

    Gan to kagaku ryoho. Cancer & chemotherapy   29   2298 - 2301   2002.11

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  • E1B-55K-deleted adenovirus expressing E1A-13S by AFP-enhancer/promoter is capable of highly specific replication in AFP-producing hepatocellular carcinoma and eradication of established tumor Reviewed

    M Takahashi, T Sato, T Sagawa, Y Lu, Y Sato, S Iyama, Y Yamada, J Fukaura, S Takahashi, K Miyanishi, T Yamashita, K Sasaki, K Kogawa, H Hamada, J Kato, Y Niitsu

    MOLECULAR THERAPY   5 ( 5 )   627 - 634   2002.5

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    DOI： 10.1006/mthe.2002.0589

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  • Induction of heat shock protein 47 synthesis by TGF-beta and IL-1 beta via enhancement of the heat shock element binding activity of heat shock transcription factor 1 Reviewed

    H Sasaki, T Sato, N Yamauchi, T Okamoto, D Kobayashi, S Iyama, J Kato, T Matsunaga, R Takimoto, T Takayama, K Kogawa, N Watanabe, Y Niitsu

    JOURNAL OF IMMUNOLOGY   168 ( 10 )   5178 - 5183   2002.5

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  • Treatment of murine collagen-induced arthritis by ex vivo extracellular superoxide dismutase gene transfer. Reviewed

    Iyama S, Okamoto T, Sato T, Yamauchi N, Sato Y, Sasaki K, Takahashi M, Tanaka M, Adachi T, Kogawa K, Kato J, Sakamaki S, Niitsu Y

    Arthritis and rheumatism   44 ( 9 )   2160 - 2167   2001.9

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  • Hepatic and splenic arterial infusion chemotherapy after transcatheter peripancreatic arterial embolization for patients with inoperable adenocarcinoma of the pancreas

    H. Homma, T. Kukitsu, S. Mezawa, T. Doi, M. Kida, K. Miyanishi, K. Takada, K. Murase, S. Iyama, Y. Niitsu

    Gan to kagaku ryoho. Cancer &amp; chemotherapy   28 ( 11 )   1558 - 1561   2001

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  • Implantation of a dual chambers port for hepatic and splenic arterial infusion chemotherapy in advanced pancreatic carcinoma with multiple liver metastasis

    T. Kukitsu, H. Homma, S. Iyama, T. Doi, M. Kida, S. Mezawa, K. Murase, K. Takada, K. Miyanishi, Y. Niitsu

    Gan to kagaku ryoho. Cancer &amp; chemotherapy   28 ( 11 )   1562 - 1564   2001

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  • Synergistic suppressive effect of double transfection of tumor necrosis factor-alpha and interleukin 12 genes on tumorigenicity of Meth-A cells Reviewed

    H Fujiwara, N Yamauchi, Y Sato, K Sasaki, M Takahashi, T Okamoto, T Sato, S Iyama, Y Koshita, M Hirayama, H Yamagishi, Y Niitsu

    JAPANESE JOURNAL OF CANCER RESEARCH   91 ( 12 )   1296 - 1302   2000.12

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  • A case of type IIa autoimmune hepatitis showing fluctuation of serum CA 19-9 level Reviewed

    T. Sato, J. Kato, Y. Sato, S. Iyama, K. Takada, S. Hagiwara, S. Takahashi, H. Kuroda, S. Mezawa, Y. Koshita, N. Yoshizaki, M. Takahashi, S. Sakamaki, Y. Niitsu

    Acta Hepatologica Japonica   41 ( 9 )   654 - 659   2000

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    DOI： 10.2957/kanzo.41.654

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  • CD4,CD8 double negative T-CLLの1例 Reviewed

    山内 尚文, 高張 大亮, 井山 諭, 大久保 俊一, 佐々木 紀幸, 河野 豊, 佐藤 勉, 加藤 淳二, 坂牧 純夫, 新津 洋司郎

    臨床血液   40 ( 9 )   901 - 901   1999.9

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  • Suicide gene therapy using transferrin (Tf)-HSV-TK-gene conjugate

    J. Fukaura, Y. Sato, K. Sasaki, M. Takahashi, T. Okamoto, T. Sato, S. Iyama, N. Yamauchi, Y. Niitsu

    Biotherapy   13 ( 5 )   625 - 627   1999

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  • Involvement of ICE-like protease and oxygen free radicals in tumor- necrosis-factor-mediated apoptosis

    S. Iyama, N. Yamauchi, T. Sato, T. Okamoto, H. Sasaki, M. Takahashi, Y. Sato, T. Hagino, D. Kobayashi, N. Watanabe, Y. Niitsu

    Biotherapy   12 ( 5 )   691 - 693   1998

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  • Gene therapy for gastrointestinal cancer using adenovirus-mediated TNF receptor-p55 gene transfer followed by systemic TNF administration

    M. Takahashi, N. Yamauchi, K. Sasaki, S. Iyama, Y. Yamada, T. Okamoto, Y. Sato, T. Sato, H. Sasaki, T. Hagino, Y. Niitsu

    Biotherapy   12 ( 5 )   583 - 585   1998

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  • Prospective evaluation of alternative donor from unrelated donor and cord blood in adult acute leukemia and myelodysplastic syndrome Reviewed International journal

    Seitaro Terakura, Tetsuya Nishida, Masashi Sawa, Tomonori Kato, Kotaro Miyao, Yukiyasu Ozawa, Tatsunori Goto, Akio Kohno, Kazutaka Ozeki, Yasushi Onishi, Noriko Fukuhara, Nobuharu Fujii, Hisayuki Yokoyama, Masanobu Kasai, Hiroatsu Iida, Nobuhiro Kanemura, Tomoyuki Endo, Hiroatsu Ago, Makoto Onizuka, Satoshi Iyama, Yuichiro Nawa, Mika Nakamae, Yasuyuki Nagata, Shingo Kurahashi, Yasuo Tomiya, Atsumi Yanagisawa, Ritsuro Suzuki, Yachiyo Kuwatsuka, Yoshiko Atsuta, Koichi Miyamura, Makoto Murata

    Bone Marrow Transplantation   55 ( 7 )   1399 - 1409   2020.7

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    A prospectively registered observational study was conducted to assess the significance of allogeneic hematopoietic stem cell transplantation from highly HLA-matched unrelated donors (UD) and cord blood (CB) on outcomes in adult acute leukemia (AL) and myelodysplastic syndrome (MDS). Between 2007 and 2015, 231 transplant-eligible patients were registered for a phase 2 study of alternative donor transplantation. After registration, a sufficient time period was given to find appropriate UD. Patients received CB transplantation (CBT) if an appropriate UD was unavailable. In total, 119 patients received CBT (106 AL and 13 MDS) and 91 patients received UD transplantation (UDT) (86 AL and 5 MDS). The median age was 39 years in both groups. The primary objective was overall survival (OS); secondary objectives included cumulative incidences of non-relapse mortality (NRM) and relapse, and disease-free survival. Diagnosis, disease status at transplantation, refined disease risk index, and hematopoietic cell transplant-specific comorbidity index did not differ between UDT and CBT. In multivariate analyses, graft source was not a significant risk factor for all objectives. In adjusted analyses, UDT and CBT showed similar OS, NRM, and relapse in this prospective study. CB can be a comparable alternative stem cell source to UD by achieving a timely transplant.

    Other Link:： http://www.nature.com/articles/s41409-020-0859-8

    DOI： 10.1038/s41409-020-0859-8

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  • Prospective Evaluation of Alternative Donor from Unrelated Volunteer Donor and Cord Blood in Adult Acute Leukemia and Myelodysplastic Syndrome: No Difference between Unrelated Donor and Cord Blood

    Seitaro Terakura, Tetsuya Nishida, Masashi Sawa, Tomonori Kato, Kotaro Miyao, Yukiyasu Ozawa, Tatsunori Goto, Akio Kohno, Kazutaka Ozeki, Yasushi Onishi, Noriko Fukuhara, Nobuharu Fujii, Hisayuki Yokoyama, Masanobu Kasai, Hiroatsu Iida, Nobuhiro Kanemura, Tomoyuki Endo, Hiroatsu Ago, Makoto Onizuka, Satoshi Iyama, Yuichiro Nawa, Mika Nakamae, Yasuyuki Nagata, Shingo Kurahashi, Yasuo Tomiya, Atsumi Yanagisawa, Ritsuro Suzuki, Yachiyo Kuwatsuka, Yoshiko Atsuta, Koichi Miyamura, Makoto Murata

    BLOOD   134   2019.11

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    DOI： 10.1182/blood-2019-124634

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  • 【悪性黒色腫】 播種性骨髄癌腫症を呈した悪性黒色腫の1例

    澤田 匡秀, 澄川 靖之, 佐藤 さゆり, 菅 裕司, 加藤 潤史, 肥田 時征, 山下 利春, 橋本 亜香利, 井山 諭

    皮膚科の臨床   59 ( 13 )   1963 - 1966   2017.12

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  • P53-RESTORING SMALL MOLECULE CP-31398 INDUCES APOPTOSIS VIA INDUCTION OF REACTIVE OXIDATIVE SPECIES IN HUMAN MULTIPLE MYELOMA

    Y. Arihara, K. Takada, Y. Kawano, N. Hayasaka, H. Nakamura, S. Kikuchi, Y. Kamihara, K. Murase, H. Ikeda, S. Iyama, T. Sato, K. Miyanishi, M. Kobune, J. Kato

    HAEMATOLOGICA   102   498 - 498   2017.6

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  • CD34/EPO-R Double Positive MDS Cells Produce Erythroferrone in Response to Erythropoietin

    Shogo Miura, Masayoshi Kobune, Soushi Ibata, Masahiro Yoshida, Satoshi Iyama, Tsutomu Sato, Kazuyuki Murase, Kohichi Takada, Kaoru Ono, Akari Hashimoto, Ayumi Tatekoshi, Yusuke Kamihara, Yusuke Sugama, Wataru Jomen, Shohei Kikuchi, Hiroshi Ikeda, Hiroto Horiguchi, Yutaka Kawano, Koji Miyanishi, Hiroyuki Kuroda, Masahiro Maeda, Junji Kato

    BLOOD   128 ( 22 )   2016.12

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  • Extracellular Vesicle microRNAs from Acute Myeloid Leukemia Are Involved in the Regulation of Adherence Junction in Bone Marrow Microenvironment.

    Masahiro Yoshida, Masayoshi Kobune, Shogo Miura, Soushi Ibata, Satoshi Iyama, Tsutomu Sato, Kazuyuki Murase, Kohichi Takada, Kaoru Ono, Akari Hashimoto, Ayumi Tatekoshi, Yusuke Kamihara, Yusuke Sugama, Shohei Kikuchi, Hiroshi Ikeda, Hiroto Horiguchi, Yutaka Kawano, Koji Miyanishi, Hiroyuki Kuroda, Masahiro Maeda, Junji Kato

    BLOOD   128 ( 22 )   2016.12

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  • Next Generation Sequencing of CD138+Myeloma Cells Could Predict Response Rate and Appropriate Therapy at Diagnosis

    Hiroshi Ikeda, Yasushi Sasaki, Soushi Ibata, Masahiro Yoshida, Ayumi Tatekoshi, Satoshi Iyama, Kazuyuki Murase, Kohichi Takada, Shohei Kikuchi, Tsutomu Sato, Masayoshi Kobune, Junji Kato

    BLOOD   128 ( 22 )   2016.12

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  • Abnormal intracellular response induced by iron overload

    73 ( 4 )   503 - 508   2016.10

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  • DEFERASIROX INDUCES APOPTOSIS THROUGH INHIBITION OF ONCOGENIC PYK2/BETA-CATENIN SIGNALING IN MULTIPLE MYELOMA CELLS

    K. Takada, Y. Kamihara, T. Sato, Y. Kawano, K. Murase, Y. Arihara, S. Kikuchi, N. Hayasaka, M. Usami, S. Iyama, K. Miyanishi, M. Kobune, J. Kato

    HAEMATOLOGICA   101   78 - 79   2016.6

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  • A PHASE 2 TRIAL OF SMALL-DOSE BORTEZOMIB, LENALIDOMIDE, AND DEXAMETHASONE (SVRD) AS CONSOLIDATION/MAINTENANCE THERAPY IN PATIENTS WITH MULTIPLE MYELOMA

    T. Sato, H. Kuroda, Y. Nagamachi, S. Iyama, A. Fujimi, Y. Kamihara, Y. Konuma, M. Yoshida, S. Ibata, A. Tatekoshi, A. Hashimoto, H. Horiguchi, K. Ono, K. Murase, K. Takada, K. Miyanishi, M. Kobune, Y. Hirayama, J. Kato

    HAEMATOLOGICA   101   792 - 793   2016.6

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  • 多発性骨髄腫における鉄代謝異常および鉄キレート剤による抗腫瘍効果の解析

    高田 弘一, 神原 悠輔, 佐藤 勉, 河野 豊, 井山 諭, 村瀬 和幸, 菊地 尚平, 堀口 拓人, 橋本 亜香利, 舘越 鮎美, 瀧本 理修, 小船 雅義, 加藤 淳二

    International Journal of Myeloma   5 ( 2 )   100 - 100   2015.5

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  • A phase I/II study of definitive chemoradiotherapy with docetaxel, nedaplatin, and 5-fluorouracil (DNF-R) for advanced esophageal cancer

    Yasushi Sato, Hiroyuki Ohnuma, Masahiro Hirakawa, Yutaka Okagawa, Takahiro Osuga, Kazuyuki Murase, Kohichi Takada, Yutaka Kawano, Satoshi Iyama, Tsuyoshi Hayashi, Tsutomu Sato, Koji Miyanishi, Rishu Takimoto, Masayoshi Kobune, Tamotsu Sagawa, Masakazu Hori, Masanori Someya, Koh-ichi Sakata, Tetsuji Takayama, Junji Kato

    JOURNAL OF CLINICAL ONCOLOGY   33 ( 3 )   2015.1

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  • Exosomes Derived from AML/MDS Cells Is Involved in Stromal Dysfunction and Bone Marrow Failure

    Hiroto Horiguchi, Masayoshi Kobune, Shohei Kikuchi, Wataru Jomen, Kazuyuki Murase, Soushi Ibata, Satoshi Iyama, Tsutomu Sato, Yusuke Kamihara, Koji Miyanishi, Yasushi Sato, Tsuyoshi Hayashi, Rishu Takimoto, Junji Kato

    BLOOD   124 ( 21 )   2014.12

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  • RADIATION-INDUCED LEIOMYOSARCOMA IN PROSTATE AFTER BRACHYTHERAPY FOR PROSTATIC ADENOCARCINOMA

    Hiroto Horiguchi, Kohichi Takada, Rishu Takimoto, Satoshi Iyama, Tsutomu Sato, Yasuo Hirayama, Toshifumi Hoki, Naoya Masumori, Tadashi Hasegawa, Junji Kato

    ANNALS OF ONCOLOGY   25   2014.10

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  • EFFICACY OF NEOADJUVANT CHEMOTHERAPY WITH DOXORUBICIN PLUS IFOSFAMIDE FOR INTERMEDIATE TO HIGH-RISK SOFT TISSUE

    Kohichi Takada, Shogo Miura, Rishu Takimoto, Yusuke Kamihara, Satoshi Iyama, Yutaka Okagawa, Yasushi Sato, Toshihiko Yamashita, Tadashi Hasegawa, Junji Kato

    ANNALS OF ONCOLOGY   25   2014.10

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  • 28-P4AM-030 骨髄異形成症候群治療薬アザシチジンの制吐療法の評価(がん薬物療法(制吐支持療法),一般演題(ポスター),新時代を拓く医療薬学フロンティア)

    中村 勝之, 野田 師正, 沖田 憲司, 高田 弘一, 井山 諭, 佐藤 勉, 瀧本 理修, 小船 雅義, 加藤 淳二, 池田 博, 林 敏昭, 石田 禎夫, 篠村 恭久, 中田 浩雅, 宮本 篤

    日本医療薬学会年会講演要旨集   24   380 - 380   2014.8

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  • CD19-TARGETING LIPOSOMES CONTAINING RAPAMYCIN INDUCE AUTOPHAGIC CELL DEATH IN BURKITT'S LYMPHOMA CELLS

    T. Sato, K. Ono, S. Iyama, A. Tatekoshi, A. Hashimoto, Y. Kamihara, H. Horiguchi, K. Takada, T. Hayashi, K. Miyanishi, Y. Sato, R. Takimoto, M. Kobune, J. Kato

    HAEMATOLOGICA   99   135 - 135   2014.6

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  • DISTURBANCE OF EPIGENETIC STATUS IN STROMAL CELLS COULD BE INDUCED BY INTERACTION WITH MDS/AML-INITIATING CELLS

    M. Kobune, H. Horiguchi, S. Kikuchi, K. Takada, S. Iyama, T. Sato, A. Hashimoto, A. Tatekoshi, T. Hayashi, K. Miyanishi, Y. Sato, R. Takimoto, J. Kato

    HAEMATOLOGICA   99   84 - 84   2014.6

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  • Markers of bone metabolism in multiple myeloma patients switched from zoledronic acid to denosumab

    TATEKOSHI Ayumi, SATO Tsutomu, IBATA Soushi, HASHIMOTO Akari, KAMIHARA Yusuke, HORIGUCHI Hiroto, ONO Kaoru, TAKADA Kohichi, IYAMA Satoshi, TAKIMOTO Rishu, KOBUNE Masayoshi, KATO Junji

    Rinsho Ketsueki   55 ( 11 )   2271 - 2276   2014

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    To date, intravenous drip infusion of zoledronic acid (ZA) has mainly been used for the treatment and prevention of skeletal-related events (SRE) in patients with multiple myeloma (MM). Recently, denosumab, a fully humanized monoclonal antibody against receptor activator of nuclear factor-κB ligand (RANKL), has also become available for the same purpose, but little is known about the impact of switching from ZA to denosumab. Herein, we present a retrospective study on bone metabolic markers in 10 MM patients initially treated with ZA and then switched to denosumab. Consequently, the levels of bone resorption markers, tartrate-resistant acid phosphatase 5b (TRACP-5b) and serum type-I collagen crosslinked N-telopeptide (sNTX), significantly decreased after denosumab treatment, while the levels of bone formation markers, osteocalcin (OC) and bone-specific alkaline phosphatase (BAP), showed no apparent changes. No patient developed severe hypocalcemia with denosumab treatment. In one patient not given chemotherapy, the M-protein level increased after switching from ZA to denosumab and plateaued when ZA was restarted. Based on this finding, we anticipate that switching from ZA to denosumab would exert a stronger suppressive effect on osteoclasts, but the anti-myeloma activity of ZA must be taken into consideration.

    DOI： 10.11406/rinketsu.55.2271

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  • 土-P3-462 多発性骨髄腫に対するレナリドミド療法の有害事象の解析と薬剤管理指導(3)(がん薬物療法(その他),ポスター発表,一般演題,再興、再考、創ろう最高の医療の未来)

    中村 勝之, 野田 師正, 高田 弘一, 井山 諭, 佐藤 勉, 瀧本 理修, 小船 雅義, 加藤 淳二, 安井 寛, 池田 博, 林 敏昭, 石田 禎夫, 篠村 恭久, 中田 浩雅, 宮本 篤

    日本医療薬学会年会講演要旨集   23   328 - 328   2013.8

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  • 北海道における成人T細胞性白血病/リンパ腫に対する全同種造血幹細胞移植成績

    重松明男, 重松明男, 田中淳司, 小林直樹, 安井寛, 進藤基博, 柿木康孝, 幸田久平, 井山諭, 黒田裕行, 堤豊, 橋野聡, 今村雅寛, 豊嶋崇徳

    日本造血細胞移植学会総会プログラム・抄録集   35th   190   2013.2

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    J-GLOBAL

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  • Role of Allogeneic Stem Cell Transplantation for Adult T-Cell Leukemia in an HTLV-1 Non-Endemic Area of Japan.

    Akio Shigematsu, Junji Tanaka, Naoki Kobayashi, Hiroshi Yasui, Motohiro Shindo, Yasutaka Kakinoki, Kakinoki Yasutaka, Satoshi Iyama, Kuroda HIroyuki, Tsutsumi Yutaka, Satoshi Hashino, Masahiro Imamura, Takanori Teshima

    BLOOD   120 ( 21 )   2012.11

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    DOI： 10.1182/blood.V120.21.3089.3089

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  • P1-272 多発性骨髄腫に対するレナリドミド療法の有害事象の解析と薬剤管理指導(2)(がん薬物療法(他の副作用対策),ポスター,一般演題,岐路に立つ医療〜千年紀の目覚め〜よみがえれ!ニッポン!薬の改革は我らが手で!)

    中村 勝之, 野田 師正, 林 敏昭, 石田 禎夫, 篠村 恭久, 高田 弘一, 井山 諭, 加藤 淳二, 中田 浩雅, 宮本 篤

    日本医療薬学会年会講演要旨集   22   312 - 312   2012.10

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  • RETROSPECTIVE ANALYSIS OF IFOSFAMIDE ENCEPHALOPATHY IN PATIENTS WITH BONE AND SOFT TISSUE SARCOMAS

    K. Takada, R. Takimoto, T. Yoshinaga, S. Iyama, K. Ono, K. Murase, T. Sato, K. Miyanishi, Y. Sato, M. Kobune, T. Soma, S. Nagoya, T. Yamashita, A. Watanabe, J. Kato

    ANNALS OF ONCOLOGY   23   130 - 130   2012.10

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  • SUCCESSFUL INDUCTION AND LONG-TERM FOLLOW-UP AFTER FLAG-MG THERAPY: CHEMOTHERAPY FOLLOWED BY GEMTUZUMAB OZOGAMICIN IN SIX PATIENTS WITH RELAPSED OR REFRACTORY ACUTE MYELOID LEUKEMIA

    Y. Hirayama, T. Terui, K. Koike, T. Kusakabe, T. Ishihara, K. Ishitani, S. Iyama, T. Sato, R. Takimoto, M. Kobune, J. Kato

    ANNALS OF ONCOLOGY   23   165 - 166   2012.10

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  • CASE REPORt : Effective Treatment with both Chemo-radiotherapy and Donor Lymphocyte Infusion in for a Patient with Recurrent Myeloid Sarcoma after Reduced Intensity Stem Cell Transplantation

    109 ( 5 )   893 - 896   2012.5

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  • P-0322 多発性骨髄腫に対するレナリドミド療法の有害事象の解析と薬剤管理指導(一般演題 ポスター発表,がん薬物療法(その他),Enjoy Pharmacists' Lifestyles)

    中村 勝之, 野田 師正, 安井 寛, 池田 博, 林 敏昭, 石田 禎夫, 篠村 恭久, 村瀬 和幸, 井山 諭, 佐藤 勉, 瀧本 理修, 小船 雅義, 加藤 淳二, 中田 浩雅, 宮本 篤

    日本医療薬学会年会講演要旨集   21   235 - 235   2011.9

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  • A case of ulcerative colitis accompanied with myelodysplastic syndrome successfully treated by cyclosporine

    Sho Takahashi, Yasushi Sato, Tamotsu Sagawa, Shingo Tanaka, Kazuyuki Murase, Kohichi Takada, Satoshi Iyama, Tsutomu Sato, Rishu Takimoto, Masayoshi Kobune, Ganji Kuroiwa, Michiaki Hirayama, Tetsuro Okamoto, Junji Kato

    Journal of Japanese Society of Gastroenterology   108 ( 8 )   1405 - 1412   2011.8

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    DOI： 10.11405/nisshoshi.108.1405

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  • Case report: Successful treatment of refractory hemophagocytic lymphohistiocytosis with infliximab in a rheumatoid arthritis patient

    108 ( 1 )   164 - 167   2011.7

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  • Tuberculous pleuritis with onset of refractory pleural effusion after chemoradiotherapy for esophageal cancer

    Masahiro Hirakawa, Yasushi Sato, Hiroyuki Ohnuma, Tamotsu Sagawa, Hirotoshi Ishiwatari, Kazuyuki Murase, Satoshi Iyama, Tsuyoshi Hayashi, Tsutomu Sato, Koji Miyanishi, Masayoshi Kobune, Rishu Takimoto, Junji Kato

    Journal of Japanese Society of Gastroenterology   108 ( 2 )   231 - 237   2011.2

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    DOI： 10.11405/nisshoshi.108.231

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  • Long-Term Production System of Red Blood Cells Using Human Cord Blood and Stromal Cells.

    Masayoshi Kobune, Shohei Kikuchi, Kazuyuki Murase, Satoshi Iyama, Tsutomu Sato, Koji Miyanishi, Yasushi Sato, Rishu Takimoto, Junji Kato

    BLOOD   116 ( 21 )   1317 - 1317   2010.11

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  • SUCCESSFUL TREATMENT OF HCC SIZED 10MM BY COINFECTION OF REPLICATION COMPETENT ADV AND ADVP53 WITH AFPPROMOTERS, AND LOW DOSE 5-FU IN COMBINATION

    Tamotsu Sagawa, Yasuyuki Yamada, Minoru Takahashi, Yasushi Sato, Masayoshi Kobune, Rishu Takimoto, Junki Fukaura, Satoshi Iyama, Tsutomu Sato, Takuya Matsunaga, Junji Kato, Katsunori Sasaki, Hirofumi Hamada, Yoshiro Niitsu

    JOURNAL OF GENE MEDICINE   11 ( 12 )   1161 - 1161   2009.12

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  • CD34+Cobblestone Area-Forming Cells Are a Valuable Indicator to Screen the Soluble Inhibitors of Hematopoiesis in the Serum of Aplastic Anemia and MDS Patients.

    Shohei Kikuchi, Masayoshi Kobune, Kazuyuki Murase, Satoshi Iyama, Tsutomu Sato, Yutaka Kawano, Koji Miyanishi, Yasushi Sato, Rishu Takimoto, Junji Kato

    BLOOD   114 ( 22 )   584 - 584   2009.11

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  • Cyclopamine Induced Apoptosis in Primary CD34+Acute Leukemic Cells.

    Masayoshi Kobune, Kazuyuki Murase, Satoshi Iyama, Tsutomu Sato, Rishu Takimoto, Yutaka Kawano, Shohei Kikuchi, Koji Miyanishi, Yasushi Sato, Junji Kato

    BLOOD   114 ( 22 )   1450 - 1450   2009.11

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  • Acute mesenteric ischemia associated with thrombotic thrombocytopenic purpura in a patient with systemic lupus erythematosus

    104 ( 3 )   575 - 578   2009.9

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  • Successful induction of complete remission by gemtuzumab ozogamicin following chemotherapy in three patients with relapsed or refractory acute myeloid leukemia

    HIRAYAMA Yasuo, TERUI Takeshi, KOIKE Kazuhiko, NEDA Hiroshi, ISHITANI Kunihiko, KOHDA Kyuhei, KURODA Hiroyuki, IYAMA Satoshi, SATO Tsutomu, KOBUNE Masayoshi, TAKIMOTO Rishu, KATO Junji

    The Japanese journal of clinical hematology   50 ( 8 )   663 - 665   2009.8

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    DOI： 10.11406/rinketsu.50.663

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  • Wnt3 Signaling Augments integrin beta 1-Dependent Adhesion-Mediated Drug Resistance of Multiple Myeloma in Autocrine and Paracrine Manner

    Masayoshi Kobune, Kazuyuki Murase, Satoshi Iyama, Tsutomu Sato, Yutaka Kawano, Shohei Kikuchi, Koji Miyanishi, Rishu Takimoto, Junji Kato

    BLOOD   112 ( 11 )   599 - 600   2008.11

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  • Interaction with Human Stromal Cells Enhances CXCR4 Expression and Engraftment of Cord Blood Lin-CD34-Cells Via Writ Signaling.

    Masayoshi Kobune, Kazuyuki Murase, Satoshi Iyama, Tsutomu Sato, Shohei Kikuchi, Yutaka Kawano, Kohichi Takada, Koji Miyanishi, Rishu Takimoto, Junji Kato

    BLOOD   112 ( 11 )   810 - 810   2008.11

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  • SUCCESSFUL REMOVAL OF FOREIGN BODIES LOCATED IN THE SMALL BOWEL USING DOUBLE BALLOON ENTEROSCOPY

    SAGAWA Tamotsu, TAKAYAMA Tetsuji, SATO Yasushi, TAKAHASHI Sho, TANAKA Shingo, OZASA Risa, IYAMA Satoshi, KURODA Hiroyuki, KATO Junji, NIITSU Yoshiro

    50 ( 10 )   2684 - 2690   2008.10

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    DOI： 10.11280/gee1973b.50.2684

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  • 骨髄腫から産生されるWnt3はRhoA/ROCKシグナルを活性化し、インテグリンα6β1依存性のCAM-DRを惹起する

    小船 雅義, 河野 豊, 井山 諭, 佐藤 勉, 瀧本 理修, 松永 卓也, 加藤 淳二, 濱田 洋文, 新津 洋司郎

    臨床血液   48 ( 9 )   870 - 870   2007.9

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    Ichushi

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  • A CASE OF PYLORIC STENOSIS AFTER ENDOSCOPIC SUBMUCOSAL DISSECTION OF EARLY GASTRIC CANCER

    SAGAWA Tamotsu, SATO Yasushi, TAKAYAMA Tetsuji, ABE Seiichiro, HIRAKAWA Masahiro, ARAKI Naoko, OZASA Risa, IYAMA Satoshi, KATO Junji, NIITSU Yoshiro

    49 ( 7 )   1681 - 1687   2007.7

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    DOI： 10.11280/gee1973b.49.1681

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  • [Superior mesenteric and portal vein thrombosis in a polycythemia vera patient with JAK2 mutation].

    Naoko Araki, Rishu Takimoto, Hiroki Chiba, Hironobu Araki, Tsutomu Sato, Satoshi Iyama, Masahiro Hirakawa, Kaoru Ono, Yutaka Kawano, Koichi Takada, Koji Miyanishi, Masayoshi Kobune, Takuya Matsunaga, Junji Kato, Tokiko Nakamura, Yoshiro Niitsu

    [Rinsho ketsueki] The Japanese journal of clinical hematology   48 ( 7 )   554 - 8   2007.7

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    A 47-year-old woman was admitted to our hospital in December 1994 with polycythemia. The patient's red blood cell volume was 33 ml/kg and bone marrow cytology was able to rule out other myeloproliferative diseases such as chronic myelogenous leukemia, essential thrombocytosis and myelofibrosis. The patient was diagnosed as having polycythemia vera. She had undergone only phlebotomy until 1999 when the thrombocytosis appeared, subsequent to which she was treated with oral hydroxyurea. However, in March 2006, she developed upper abdominal pain and was admitted to our hospital on March 14th, 2006. Computed tomography scan revealed thromboses in the portal and superior mesenteric veins. Anticoagulation therapy delivered intravenously via the superior mesenteric vein dramatically improved her symptoms and liver function. She is currently on anticoagulation therapy in our outpatient clinic.

    DOI： 10.11406/rinketsu.48.554

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  • Factor XI deficiency caused by a mutation of Gly400Val

    SATO Tsutomu, IYAMA Satoshi, ARAKI Naoko, MURASE Kazuyuki, SATO Yasushi, KOBUNE Masayoshi, TAKIMOTO Rishu, MATSUNAGA Takuya, KATO Junji, KURODA Hiroyuki, NIITSU Yoshiro

    48 ( 2 )   148 - 150   2007.2

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    DOI： 10.11406/rinketsu.48.148

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  • Gastric relapse of stage I ocular adnexal : mucosa-associated lymphoid tissue lymphoma

    SATO Tsutomu, TAKIMOTO Rishu, IYAMA Satoshi, ONO Kaoru, TANAKA Shingo, ARAKI Naoko, NISHIIE Kiwami, MURASE Kazuyuki, SATO Yasushi, KOBUNE Masayoshi, MATSUNAGA Takuya, KATO Junji, NIITSU Yoshiro

    Rinsho Ketsueki   48 ( 1 )   56 - 60   2007.1

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    A 57-year-old male with right ocular adnexal mucosa-associated lymphoid tissue lymphoma (MALT lymphoma) was successfully treated with local radiation therapy. The gastroendoscopic examination revealed a slight inflammatory change of the gastric mucosa, and the urease test was positive. Eradication therapy against <i>Helicobacter pylori</i> was successfully done, however, the patient developed gastric MALT lymphoma two years after the initial treatment. Southern blot analysis of the immunoglobulin heavy chain gene rearrangement revealed that the lymphoma cells from the ocular adnexal and gastric MALT lymphomas were identical, indicating that the gastric MALT lymphoma was not the primary but the metastatic region from the ocular adnexal MALT lymphoma. Further, immunohistochemical staining demonstrated the expression of integrin &alpha;4&beta;7 on ocular adnexal MALT lymphoma cells, which is essential for the adhesion of lymphocytes to gastrointestinal mucosa. These results indicate that ocular adnexal MALT lymphoma cells can metastasize to the stomach, depending on the adhesional function of integrin &alpha;4&beta;7.

    DOI： 10.11406/rinketsu.48.56

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  • Report of an autopsy case of colon cancer with amyotrophic lateral sclerosis

    Yasushi Sato, Tetsuji Takayama, Tomomi Nikaido, Yuko Wada, Tamotsu Sagawa, Seiichiro Abe, Tsutomu Sato, Satoshi Iyama, Kazuyuki Murase, Hironobu Araki, Yasuhiro Sato, Junji Kato, Yoshiro Niitsu, Hideki Chiba

    Japanese Journal of Gastroenterology   104 ( 9 )   1365 - 1370   2007

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    DOI： 10.11405/nisshoshi.104.1365

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  • Peripheral T-cell lymphoma presenting with eosinophilia due to Interleukin-5 produced by lymphoma cells

    MATSUNAGA Takuya, SATO Tsutomu, IYAMA Satoshi, TANAKA Shingo, MURASE Kazuyuki, SATO Yasushi, KOBUNE Masayoshi, TAKIMOTO Rishu, KATO Junji, KURODA Hiroyuki, NIITSU Yoshiro

    Rinsho Ketsueki   47 ( 11 )   1457 - 1462   2006.11

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    A 72-year-old male was admitted to our hospital to determine the cause of neck lymphadenopathies. He was diagnosed pathologically by a lymph node biopsy as having peripheral T-cell lymphoma (PTCL). He also had developed eosinophilia and his serum concentration of Interleukin-5 (IL-5) was extremely high. Immunostaining of a resected lymph node revealed that there were lymphoma cells which were stained with anti-IL-5 antibody. After 2 courses of CHOP therapy, the lymphadenopathies and eosinophilia disappeared and the concentration of serum IL-5 was normalized. It was suggested that IL-5 produced by lymphoma cells had induced his eosinophilia.

    DOI： 10.11406/rinketsu.47.1457

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  • A case of recurrent biliary cystadenocarcinoma successfully treated with 5FU/CDDP systemic chemotherapy

    Satoshi Iyama, Yasuo Takahashi, Naoaki Shintani, Koshi Fujikawa, Syunichi Ohkubo, Yasushi Sato, Tsutomu Sato, Yasuhiro Sato, Keisuke Ohnuma, Yoshiro Niitsu

    Japanese Journal of Gastroenterology   103 ( 10 )   1163 - 1168   2006.10

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    DOI： 10.11405/nisshoshi.103.1163

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  • Enteropathy-type T-cell lymphoma with CD8 and CD56 expression

    SATO Tsutomu, MATSUNAGA Takuya, IYAMA Satoshi, SAKAI Toshiro, MURASE Kazuyuki, SATO Yasushi, KOBUNE Masayoshi, TAKIMOTO Rishu, KATO Junji, NIITSU Yoshiro

    47 ( 7 )   645 - 649   2006.7

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    DOI： 10.11406/rinketsu.47.645

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  • De novo CD5-positive diffuse large B-cell lymphoma associated with autoimmune hemolytic anemia presenting as erythroid hypoplasia

    KURODA Hiroyuki, MATSUNAGA Takuya, IYAMA Satoshi, TAKIMOTO Rishu, SHIRAO Sayaka, KIDA Masaya, WATANABE Hideki, KONUMA Yu-ichi, HIRAYAMA Yasuo, KOHDA Kyuhei, NIITSU Yoshiro

    47 ( 7 )   633 - 638   2006.7

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    DOI： 10.11406/rinketsu.47.633

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  • Diagnostic utility of fluorescence in situ hybridization (FISH) in mantle cell lymphoma in leukemic phase

    Japanese journal of cancer clinics   52 ( 6 )   455 - 461   2006

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  • A case of metastatic small bowel and gastric cancer from the lung caused intussusception

    Japanese journal of cancer clinics   52 ( 2 )   77 - 83   2006

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  • Successful treatment with oral ribavirin of adenovirus-associated hemophagocytic syndrome in a stem cell transplantation recipient

    IYAMA Satoshi, MATSUNAGA Takuya, FUJIMI Akihito, MURASE Kazuyuki, KURIBAYASI Kageaki, SATO Tsutomu, HIRAYAMA Yasuo, SAKAMAKI Sumio, KOHDA Kyuhei, NIITSU Yoshiro

    Rinsho Ketsueki   46 ( 5 )   363 - 367   2005.5

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    A 51-year-old woman with severe aplastic anemia underwent allogeneic peripheral blood stem cell transplantation using blood stem cells from an HLA-identical sibling. Adenovirus type 11 hemorrhagic cystitis developed and progressed to nephritis and hemophagocytic syndrome. Oral ribavirin was effective not only for the hemorrhagic cystitis and nephritis but also for the hemophagocytic syndrome. Since therapeutic strategies for adenovirus infection after hematopoietic stem cell transplantation have not been established, we present our case and discuss the therapeutic approach.

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  • 11. 臍帯血移植後にドナー細胞由来の急性骨髄性白血病(AML)を発症した成人T細胞性白血病リンパ腫(ATLL)(日本アフェレシス学会第24回北海道地方会抄録)(<特集>アフェレシスにおけるセイフティーマネジメント)

    村瀬 和幸, 松永 卓也, 栗林 景晶, 井山 諭, 菊池 尚平, 藤見 章仁, 新津 洋司郎, 古川 勝久

    日本アフェレシス学会雑誌   24 ( 1 )   121 - 121   2005.2

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  • A novel treatment for early gastrointestinal carcinoma by ultrasonic endoscopic mucosal stripping

    OHTA Hidetoshi, SHINTANI Naoaki, FUJIKAWA Koshi, IYAMA Satoshi, TAKAHASHI Yasuo, NOBUOKA Atsushi, DOI Tadashi, NAKAMURA Tokiko, TAKAYAMA Tetsuji, NATORI Hiroshi

    31 ( 4 )   141 - 148   2004.12

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  • 免疫療法の進歩 (特別企画 がんの最新知識)

    佐藤 勉, 井山 諭, 新津 洋司郎

    からだの科学   ( 238 )   86 - 91   2004.9

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    Other Link:： http://search.jamas.or.jp/link/ui/2004276961

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  • A case of primary biliary cirrhosis with HLA-DR 8 complicated by polymyositis

    SATO Tsutomu, KATO Junji, SATO Yasushi, IYAMA Satoshi, TAKADA Kohichi, OKU Takatomi, TAKAHASHI Sho, MACHIDA Takurou, KOBUNE Masayoshi, MATSUNAGA Takuya, TAKAHASHI Minoru, NIITSU Yoshiro

    Kanzo   44 ( 9 )   455 - 459   2003.9

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    DOI： 10.2957/kanzo.44.455

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  • A case of cholangiocellular carcinoma effectively treated with combination chemotherapy of gemcitabine and 5-FU

    TAKANASHI Kunihiro, HOMMA Hisato, MEZAWA Shin-ichi, DOI Tadashi, AKIYAMA Takehide, HIRATA Ken-ichiro, IYAMA Satoshi

    Kanzo   44 ( 6 )   301 - 306   2003.6

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    Language：Japanese   Publisher：The Japan Society of Hepatology  

    DOI： 10.2957/kanzo.44.301

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  • A case of polyarteritis nodosa treated by methotrexate: Follow-up study of hepatic arteriography

    Kunihiro Takanashi, Hisato Homma, Shin-Ichi Mezawa, Tadashi Doi, Takehide Akiyama, Ken Murakami, Koichi Takada, Takehiro Kukitsu, Kazuyuki Murase, Satoshi Iyama, Koji Miyanishi, Yoshiro Niitsu

    Acta Hepatologica Japonica   44 ( 12 )   649 - 655   2003

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    Language：Japanese   Publisher：Japan Society of Hepatology  

    DOI： 10.2957/kanzo.44.649

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  • Successful treatment of advanced peripheral T-cell lymphoma with an angiocentric growth pattern complicated with hemophagocytic syndrome by high-dose chemotherapy and autologous peripheral blood stem cell transplantation

    T Sato, K Kogawa, S Iyama, D Kobayashi, Y Sato, K Kuribayashi, K Takada, S Hagiwara, T Oku, S Takahashi, T Matsunaga, M Takahashi, T Terui, J Kato, Y Niitsu

    ANNALS OF HEMATOLOGY   81 ( 12 )   739 - 743   2002.12

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  • <Abstract of Published Report>Treatment of murine collagen-induced arthritis by ex vivo extracellular superoxide dismutase gene transger.

    IYAMA Satoshi, OKAMOTO Tetsuro, SATO Tsutomu, YAMAUCHI Naofumi, SATO Yasushi, SASAKI Katsunori, TAKAHASHI Minoru, TANAKA Maki, ADACHI Tetsuo, KOGAWA Katsuhisa, KATO Junji, SAKAMAKI Sumio, NIITSU Yoshiro

    The annual proceedings of Gifu College of Pharmacy   51   82 - 82   2002.6

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    Language：English   Publisher：Gifu Pharmaceutical University  

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  • A case of true malignant histiocytosis: identification of histiocytic origin with use of immunohistochemical and immunocytogenetic methods

    T Sato, T Terui, K Kogawa, Y Nagaoka, Y Sato, S Iyama, K Takada, S Hagiwara, S Takahashi, T Oku, T Matsunaga, M Takahashi, J Kato, S Sakamaki, T Torigoe, N Sato, M Hirayama, Y Niitsu

    ANNALS OF HEMATOLOGY   81 ( 5 )   285 - 288   2002.5

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  • A case of pancreatic ascites due to rupture of pancreatic pseudocyst successfully treated with continuous arterial infusion of nafamostat mesilate

    DOI Tadashi, HOMMA Hisato, MEZAWA Shinichi, KIDA Masaya, KUKITSU Takehiro, MIYANISHI Kouji, MURASE Kazuyuki, TAKADA Kouichi, IYAMA Satoshi, NIITSU Youshirou

    Nippon Shokakibyo Gakkai Zasshi   98 ( 11 )   1304 - 1308   2001.11

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    Language：Japanese   Publisher：The Japanese Society of Gastroenterology  

    DOI： 10.11405/nisshoshi1964.98.1304

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  • Treatment of murine collagen-iduced arthritis by Ex-vivo EC-SOD gene transfer

    IYAMA Satoshi

    Japanese Journal of Clinical Immunology   23 ( 6 )   542 - 542   2000.12

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    Language：Japanese   Publisher：The Japan Society for Clinical Immunology  

    DOI： 10.2177/jsci.23.542

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  • Pure red cell aplasia induced by clomipramine hydrochloride in a patient with SLE

    SATO Tsutomu, KOGAWA Katsuhisa, HIRAYAMA Yasuo, SATO Yasushi, NOBUOKA Atsushi, KURIBAYASHI Kageaki, IYAMA Satoshi, TAKADA Kouichi, HAGIWARA Seiya, TAKAHASHI Shou, KATO Junji, SAKAMAKI Sumio, ISHIGAKI Seishi, NIITSU Yoshiro

    Rinsho Ketsueki   41 ( 8 )   648 - 652   2000.8

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    Language：Japanese   Publisher：The Japanese Society of Hematology  

    A 48-year-old woman, who had been suffering from systemic lupus erythematosus (SLE), developed normochromic normocytic anemia after receiving clomipramine hydrochloride. Her reticulocyte count was low, and a bone marrow aspirate revealed erythroid hypoplasia without involvement of other cell lines. Thus a diagnosis of pure red cell aplasia (PRCA) was made. The anemia gradually resolved following withdrawal of the drug. Although several drugs are known to cause PRCA, this is the first time that clomipramine hydrochloride has been reported to have such an effect. The underlying SLE in this case suggested the possible immunological pathogenesis of drug-induced PRCA.

    DOI： 10.11406/rinketsu.41.648

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  • A case of high molecular weight insulin-like growth factor-II (IGF-II)-producing hepatoma associated with frequent hypoglycemia and rapid-growth

    SATO Tsutomu, KATO Juniji, HONMA Hisato, KURA Toshirou, OHI Motoo, MURAKAMI Ken, SATO Yasushi, IYAMA Satoshi, TAKADA Kouich, AGIWARA Seiya, TAKAHASHI Minoru, SAKAMAKI Sumio, NIITSU Yoshiro

    Kanzo   41 ( 5 )   346 - 351   2000.5

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    Language：Japanese   Publisher：The Japan Society of Hepatology  

    DOI： 10.2957/kanzo.41.346

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  • 潰瘍性大腸炎の経過中に再発性多発性軟骨炎を合併した1例

    河野 豊, 山内 尚文, 由崎 直人, 岡本 哲郎, 高山 哲治, 井山 諭, 加藤 淳二, 坂牧 純夫, 平山 眞章, 西里 卓次

    リウマチ   40 ( 2 )   546 - 546   2000.4

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    Language：Japanese   Publisher：(一社)日本リウマチ学会  

    Ichushi

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  • Evaluation of gastric cancer diameter using three dimensional helical CT

    M Hirayama, Y Hirano, H Matsuya, M Iriyama, E Sasaki, Y Sato, Y Nishibori, S Son, T Sakawaki, J Fukaura, S Iyama, Y Niitsu

    GASTROENTEROLOGY   116 ( 4 )   A422 - A422   1999.4

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    Language：English   Publishing type：Research paper, summary (international conference)  

    Web of Science

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  • 癌に対する遺伝子治療

    高橋 稔, 井山 諭, 新津 洋司郎

    Cancer frontier   1 ( 1 )   119 - 126   1999

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    Language：Japanese   Publisher：医薬ジャーナル社  

    Other Link:： http://search.jamas.or.jp/link/ui/2000081452

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  • Three dimensional analysis for gastric cancer using helical CT scanners.

    M Hirayama, J Fukaura, Y Hirano, H Matsuya, M Iriyama, E Sasaki, Y Urushizaki, N Ohmi, T Sakawaki, T Kurotaki, S Iyama, H Muramatsu, M Kida, Y Niitsu

    GASTROENTEROLOGY   114 ( 4 )   A611 - A611   1998.4

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    Language：English   Publishing type：Research paper, summary (international conference)  

    Web of Science

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Awards

  • Canon 画論32nd The Best Image，優秀賞

    2024.12  

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  • 小越章平記念 Best Paer in The Year 2021

    2022.5   Japanese Society for Clinical Nutrition and Metabolism   Possible clinical outcomes using early enteral nutrition in individuals with allogeneic hematopoietic stem cell transplantation: A single-center retrospective study.

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Research Projects

  • がん化学療法時の栄養状態に関わる腸管機能モニタリングの確立

    Grant number：23K10848  2023.4 - 2026.3

    日本学術振興会  科学研究費助成事業  基盤研究(C)

    井山 諭, 小船 雅義, 高田 弘一

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    Grant amount：\4680000 （ Direct Cost: \3600000 、 Indirect Cost：\1080000 ）

    １）院内での倫理委員会申請許可後より，患者保存資料を用いた研究を開始している。ジアミンオキシダーゼ値に関してはELISAシステムによる測定を開始した。測定の結果，同種造血幹細胞移植に伴う前処置（大量化学療法）の後，血中ジアミンオキシダーゼ値は一時的に低下し，多くの場合2週間後に最低値となることが分かった。これは患者が前処置に伴い経口栄養摂取不良状態になる時期と一致しており，腸管機能モニタリングに有用である可能性が示唆された。経過としては，腸管機能が良好に保たれる患者の場合には，おおよそday14以降で緩やかな改善を認めるが，腸管機能に問題がある場合にはジアミンオキシダーゼ値の回復遅延が見られることが分かった。
    ２）次世代シークエンサーを用いた腸内細菌叢検査は20検体施行した。経過で細菌叢の推移が見られる症例や，移植開始時点ですでに顕著なdysbiosisが見られる症例があることが判明した。しかしながら検出される細菌の種類には一定の傾向はなく，患者間でばらつきがあることが分かった。
    今後ジアミンオキシダーゼ値の測定以外に，活性値の測定と実測値との違いに関する検討を加えたいと考えている。また，腸内細菌叢の関係や，移植後の移植片対宿主病（GVHD）の関連性などに関しても患者情報と照らし合わせた調査を続けたいと考えている。

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  • Development of new therapy for AML by targeting of neuropeptide-PTH2R system

    Grant number：22K08509  2022.4 - 2025.3

    Japan Society for the Promotion of Science  Grants-in-Aid for Scientific Research  Grant-in-Aid for Scientific Research (C)

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    Grant amount：\4160000 （ Direct Cost: \3200000 、 Indirect Cost：\960000 ）

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  • Analysis of the development and pathogenesis of AML/MDS via extracellular vesicles

    Grant number：19K08871  2019.4 - 2022.3

    Japan Society for the Promotion of Science  Grants-in-Aid for Scientific Research Grant-in-Aid for Scientific Research (C)  Grant-in-Aid for Scientific Research (C)

    Kobune Masayoshi

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    Authorship：Coinvestigator(s) 

    Grant amount：\4290000 （ Direct Cost: \3300000 、 Indirect Cost：\990000 ）

    The analysis of exome in MDS and AML has revealed the multiple mutations involved in the pathogenesis of these disorders. On the other hand, it has been increasingly focused on the dysfunction of BM microenvironment in the MDS/AML. However, little is known how the dysfunction of BM microenvironment was induced. In this study, high level of miR-7977, miR-8073, and miR-4286 were identified in extracellular vesicles from AML cells. In particular, miR-7977 effect on BM MSCs to reduce the expression of PCBP1 and STK4, resulting in the reduction of multiple mRNA and Hippo signaling, suggesting that it could be involved in the alteration of BM microenvironment favorable to leukemia cell survival. In addition, the possibility of rejuvenation by extracellular vesicles derived from immature cells was investigated. Although the expression of β galactosidase was slightly decreased, no changes of other aging markers were detected. Other strategy may be required for rejuvenation of aging MSCs.

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  • Efficacy for treating MM with DPP8/9 inhibitor.

    Grant number：15K06875  2015.4 - 2018.3

    Japan Society for the Promotion of Science  Grants-in-Aid for Scientific Research Grant-in-Aid for Scientific Research (C)  Grant-in-Aid for Scientific Research (C)

    Iyama Satoshi

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    Authorship：Principal investigator 

    Grant amount：\5200000 （ Direct Cost: \4000000 、 Indirect Cost：\1200000 ）

    Recently, the prognosis of patients with multiple myeloma (MM) has considerably improved due to the use of autologous hematopoietic stem cell transplantation and the introduction of new agents such as the immunomodulatory drugs, proteasome inhibitors. However, no curable treatment is available. We have previously shown that the DPP8/9 inhibitor, 1G244, induced MM cells to cell death by apoptosis. Hence, we demonstrated efficacy for treating MM with DPP8/9 inhibitor.

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  • Novel strategy against GVHD using NB-UVB with expansion of Treg cells

    Grant number：25461429  2013.4 - 2016.3

    Japan Society for the Promotion of Science  Grants-in-Aid for Scientific Research Grant-in-Aid for Scientific Research (C)  Grant-in-Aid for Scientific Research (C)

    Sato Tsutomu, Iyama Satoshi, Kawano Yutaka

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    Authorship：Coinvestigator(s) 

    Grant amount：\4940000 （ Direct Cost: \3800000 、 Indirect Cost：\1140000 ）

    Narrowband ultraviolet B (NB-UVB) has been widely used in dermatological phototherapy. As for the application of NB-UVB phototherapy to GVHD, we previously reported that it was highly efficacious for cutaneous lesions of acute GVHD (aGVHD) and that expansion of regulatory T (Treg) cells induced by NB-UVB might be one of the mechanisms. In order to examine whether NB-UVB irradiation through expansion of Treg cells is effective for the treatment of not only cutaneous aGVHD but also aGVHD of inner organs such as the intestine or liver, we conducted experiments in which a murine lethal aGVHD model, characterized by severe involvement of the intestine, were irradiated with NB-UVB. We found that NB-UVB irradiation improved the clinical score and survival rate. The numbers of infiltrating Treg cells in inflamed tissue of the intestine and those in spleen were increased in mice treated with NB-UVB.

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  • Establishment of iron chelation therapy to inhibit the development of MDS

    Grant number：24659466  2012.4 - 2015.3

    Japan Society for the Promotion of Science  Grants-in-Aid for Scientific Research Grant-in-Aid for Challenging Exploratory Research  Grant-in-Aid for Challenging Exploratory Research

    KOBUNE Masayoshi, KIKUCHI Shohei, IYAMA Satoshi, KATO Junji

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    Authorship：Coinvestigator(s) 

    Grant amount：\3640000 （ Direct Cost: \2800000 、 Indirect Cost：\840000 ）

    Most MDS patients eventually require red RBC transfusions for anemia and consequently develop iron overload. Excess free iron in cells catalyzes generation of reactive oxygen species that cause oxidative stress, including oxidative DNA damage. However, it is uncertain how iron-mediated oxidative stress affects the pathophysiology of MDS. We analyzed 8-OHdG levels in peripheral blood mononuclear cells (PBMC) obtained from MDS patients before and after iron chelator,deferasirox, administration. We showed that the 8-OHdG levels in MDS patients were significantly higher than those in healthy volunteers and were positively correlated with SF and chromosomal abnormalities. Importantly, the 8-OHdG levels in PBMC of MDS patients significantly decreased after deferasirox administration, suggesting that iron chelation reduced oxidative DNA damage. Thus, excess iron could contribute to the pathophysiology of MDS and iron chelation therapy could improve the oxidative DNA damage in MDS patients.

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  • Development of the lymphocyte in vitro amplification method using HHIP KO stromal cells.

    Grant number：24591427  2012.4 - 2015.3

    Japan Society for the Promotion of Science  Grants-in-Aid for Scientific Research Grant-in-Aid for Scientific Research (C)  Grant-in-Aid for Scientific Research (C)

    IYAMA Satoshi, KATO Junji, KOBUNE Masayoshi, KAMIHARA Yusuke

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    Authorship：Principal investigator 

    Grant amount：\5460000 （ Direct Cost: \4200000 、 Indirect Cost：\1260000 ）

    We have previously shown that it was difficult to evaluate 5 weeks CA-forming cells (CAFC) which is a surrogate indicator of hematopoietic stem cells because human stromal cells could not survive more than 4 weeks. In this study, we optimized surum free media, combination of cytokines and chemical agents such as stem cell factor, thrombopoietin, flt3 ligand with or without delta like protein 4 (DLL4) and GSK inhibitor. By using this media, bone marrow CD34+ cells could be cocultured for 8 weeks without disruption of the human stromal layer. Five week CAFC could be observed in all condition of cytokine combination with or without chemical inhibitor. However, because cytoplasmic appearance of cells in some CAs is quite irregular without DLL4 or GSK inhibitor, we conducted immunohistochemical staining. We found that CD34+CAFCs were exclusively observed in the presence of DLL4 or GSK inhibitor. Moreover, NOD/SCID repopulating cells were detected in the coculture containing CD34+CAFCs.

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  • Development of dual targeting therapy for cancer stem cells and niche

    Grant number：21591213  2009 - 2011

    Japan Society for the Promotion of Science  Grants-in-Aid for Scientific Research Grant-in-Aid for Scientific Research (C)  Grant-in-Aid for Scientific Research (C)

    KOBUNE Masayoshi, KIKUCHI Shohei, IYAMA Satoshi, TAKIMOTO Rishu

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    Authorship：Coinvestigator(s) 

    Grant amount：\4550000 （ Direct Cost: \3500000 、 Indirect Cost：\1050000 ）

    Aberrant reactivation of Hedgehog(Hh) signaling has been described in a wide variety of human cancers including cancer stem cells. However, involvement of Hh signaling system in bone marrow(BM) microenvironment in the development of myeloid neoplasm has remained unclear. In this study, we assessed the expression of Hh related proteins in normal human CD34+cells, CD34+leukemic/dysplastic cells and BM stromal cells. Both Indian hedgehog(Ihh) and its signal transducer, SMO were expressed in CD34+acute myeloid leukemia(AML) and myelodysplastic syndrome(MDS) derived cells, suggesting that Ihh could effect in autocrine manner. Remarkably, the intrinsic Hh signaling inhibitor, human hedgehog-interacting protein(HHIP) expression in AML/MDS-associated stromal cells was drastically lower than that in healthy donor derived stromal cells. Moreover, the HHIP expression level in BM stromal cells highly correlated with supporting activity of SMO+leukemic cells. Demethylating agent 5-aza-dC rescued the HHIP expression via demethylation of HHIP gene and reduced the leukemia-supporting activity of AML/MDS-associated stromal cells. This effect of 5-aza-dC could be negated by HHIP shRNA transfer into stromal cells. Interestingly, HHIP-reduced stromal cells preferentially migrated toward Ihh-releasing leukemic cells. These results indicate that suppression of stromal HHIP expression could be involved in the progression of AML/MDS.

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  • Molecular targeting against p38MAPK in B-cell lymphoma using anti-CD19 antibody-labeled liposome

    Grant number：19591125  2007 - 2008

    Japan Society for the Promotion of Science  Grants-in-Aid for Scientific Research Grant-in-Aid for Scientific Research (C)  Grant-in-Aid for Scientific Research (C)

    SATO Tsutomu, IYAMA Satoshi

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    Authorship：Coinvestigator(s) 

    Grant amount：\4550000 （ Direct Cost: \3500000 、 Indirect Cost：\1050000 ）

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  • Development of the system to produce large scale generation of human platelets from cord blood CD34^+ cells in vitro

    Grant number：18591076  2006 - 2007

    Japan Society for the Promotion of Science  Grants-in-Aid for Scientific Research Grant-in-Aid for Scientific Research (C)  Grant-in-Aid for Scientific Research (C)

    MATSUNAGA Takuya, IYAMA Satoshi, SATO Tsutomu

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    Authorship：Coinvestigator(s) 

    Grant amount：\3890000 （ Direct Cost: \3500000 、 Indirect Cost：\390000 ）

    We generated platelets (PLT) from cord blood (CB) CD34^+ cells employing a three-phase culture system. We first cultured 500 CB CD34^+ cells on telomerase gene-transduced human stromal cells (hTERT stroma) in serum-free medium supplemented with stem cell factor (SCF), Flt-3/Flk-2 ligand (FL) and thrombopoietin (TPO) for 14 days. We then transferred the cells to hTERT stroma and cultured for another 14 days with fresh medium containing interleukin-11 (IL-11) in addition to the original cytokine cocktail. Subsequently, we cultured the cells in a liquid culture medium containing SCF, FL, TPO and IL-11 for another 5 days to recover PLT fractions from the supernatant, which were then gel filtered to purify the PLT. The calculated yield of PLT from 1.0 unit CB (5x10^6 CD34+ cells) was 1.26 x10^<11> - 1.68 x10^<11> PLT. These numbers of PLT are equivalent to 2.5-3.4 units of random donor-derived PLT or 2/5-6/10 of a single apheresis PLT. The CB-derived PLT exhibited features quite similar to those from peripheral blood in morphology, as revealed by electron micrographs, and in function, as revealed by fibrinogen/ADP aggregation, with the appearance of P-selectin and activated glycoprotein IIb-IIIa antigens. Thus this culture system may be applicable for large scale generation of PLT for future clinical usage.

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