Details of a Researcher - IYAMA Satoshi

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A CASE OF PYLORIC STENOSIS AFTER ENDOSCOPIC SUBMUCOSAL DISSECTION OF EARLY GASTRIC CANCER

SAGAWA Tamotsu, SATO Yasushi, TAKAYAMA Tetsuji, ABE Seiichiro, HIRAKAWA Masahiro, ARAKI Naoko, OZASA Risa, IYAMA Satoshi, KATO Junji, NIITSU Yoshiro

日本消化器内視鏡学会雑誌 = Gastroenterological endoscopy 49 ( 7 ) 1681 - 1687 2007.07

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[Superior mesenteric and portal vein thrombosis in a polycythemia vera patient with JAK2 mutation].

Naoko Araki, Rishu Takimoto, Hiroki Chiba, Hironobu Araki, Tsutomu Sato, Satoshi Iyama, Masahiro Hirakawa, Kaoru Ono, Yutaka Kawano, Koichi Takada, Koji Miyanishi, Masayoshi Kobune, Takuya Matsunaga, Junji Kato, Tokiko Nakamura, Yoshiro Niitsu

[Rinsho ketsueki] The Japanese journal of clinical hematology ( 日本臨床血液学会 ) 48 ( 7 ) 554 - 8 2007.07 [Domestic journal]

A 47-year-old woman was admitted to our hospital in December 1994 with polycythemia. The patient's red blood cell volume was 33 ml/kg and bone marrow cytology was able to rule out other myeloproliferative diseases such as chronic myelogenous leukemia, essential thrombocytosis and myelofibrosis. The patient was diagnosed as having polycythemia vera. She had undergone only phlebotomy until 1999 when the thrombocytosis appeared, subsequent to which she was treated with oral hydroxyurea. However, in March 2006, she developed upper abdominal pain and was admitted to our hospital on March 14th, 2006. Computed tomography scan revealed thromboses in the portal and superior mesenteric veins. Anticoagulation therapy delivered intravenously via the superior mesenteric vein dramatically improved her symptoms and liver function. She is currently on anticoagulation therapy in our outpatient clinic.

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Factor XI deficiency caused by a mutation of Gly400Val

SATO Tsutomu, IYAMA Satoshi, ARAKI Naoko, MURASE Kazuyuki, SATO Yasushi, KOBUNE Masayoshi, TAKIMOTO Rishu, MATSUNAGA Takuya, KATO Junji, KURODA Hiroyuki, NIITSU Yoshiro

臨床血液 = The Japanese Journal of Clinical Hematology 48 ( 2 ) 148 - 150 2007.02

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Gastric relapse of stage I ocular adnexal : mucosa-associated lymphoid tissue lymphoma

SATO Tsutomu, TAKIMOTO Rishu, IYAMA Satoshi, ONO Kaoru, TANAKA Shingo, ARAKI Naoko, NISHIIE Kiwami, MURASE Kazuyuki, SATO Yasushi, KOBUNE Masayoshi, MATSUNAGA Takuya, KATO Junji, NIITSU Yoshiro

Rinsho Ketsueki ( The Japanese Society of Hematology ) 48 ( 1 ) 56 - 60 2007.01

A 57-year-old male with right ocular adnexal mucosa-associated lymphoid tissue lymphoma (MALT lymphoma) was successfully treated with local radiation therapy. The gastroendoscopic examination revealed a slight inflammatory change of the gastric mucosa, and the urease test was positive. Eradication therapy against Helicobacter pylori was successfully done, however, the patient developed gastric MALT lymphoma two years after the initial treatment. Southern blot analysis of the immunoglobulin heavy chain gene rearrangement revealed that the lymphoma cells from the ocular adnexal and gastric MALT lymphomas were identical, indicating that the gastric MALT lymphoma was not the primary but the metastatic region from the ocular adnexal MALT lymphoma. Further, immunohistochemical staining demonstrated the expression of integrin α4β7 on ocular adnexal MALT lymphoma cells, which is essential for the adhesion of lymphocytes to gastrointestinal mucosa. These results indicate that ocular adnexal MALT lymphoma cells can metastasize to the stomach, depending on the adhesional function of integrin α4β7.

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Report of an autopsy case of colon cancer with amyotrophic lateral sclerosis

Yasushi Sato, Tetsuji Takayama, Tomomi Nikaido, Yuko Wada, Tamotsu Sagawa, Seiichiro Abe, Tsutomu Sato, Satoshi Iyama, Kazuyuki Murase, Hironobu Araki, Yasuhiro Sato, Junji Kato, Yoshiro Niitsu, Hideki Chiba

Japanese Journal of Gastroenterology ( The Japanese Society of Gastroenterology ) 104 ( 9 ) 1365 - 1370 2007

Amyotrophic lateral sclerosis (ALS) is a degenerative disease involving both upper and lower motor neurons and the pathogenesis of this disorder is still unknown. To date, few reports have suggested that motor neuron diseases may have a paraneoplastic origin. However, it is still under discussion whether ALS occurring in cancer patients is paraneoplastic. A 60-year-old man with rectal cancer (Stage IV) having multiple lung, liver and para-aortic lymph node metastases underwent anterior resection of the rectum as palliative surgery. He was referred to our hospital for adjuvant chemotherapy. Lung and lymph node metastases decreased after 2 courses of chemotherapy using CPT-11 and 5-FU/LV but liver metastases were enlarged, following up increase in CEA. Thereafter, he suffered from muscle weakness in hands, arms, and legs and results of neurophysiologic studies were compatible with primary lateral sclerosis (ALS). For second line chemotherapy, he was treated with low-dose CDDP/5-FU over 6 courses. As a result, the size the of metastatic lesions markedly reduced and CEA was decreased to the normal level. Although significant tumor reduction was observed, his neurological symptoms rapidly progressed. He died of aspiration pneumonia 8 months after onset of the disease. Autopsy revealed that his neuropathological findings were compatible with ALS, and it was thought to be the primary cause of death in the because of absence of cancer progression. In this case the neurological syndrome was not affected by cancer therapy. Thus our case does not support the hypothesis that ALS in associated with cancer and the relationship between both disorders remains uncertain.

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Peripheral T-cell lymphoma presenting with eosinophilia due to Interleukin-5 produced by lymphoma cells

MATSUNAGA Takuya, SATO Tsutomu, IYAMA Satoshi, TANAKA Shingo, MURASE Kazuyuki, SATO Yasushi, KOBUNE Masayoshi, TAKIMOTO Rishu, KATO Junji, KURODA Hiroyuki, NIITSU Yoshiro

Rinsho Ketsueki ( The Japanese Society of Hematology ) 47 ( 11 ) 1457 - 1462 2006.11

A 72-year-old male was admitted to our hospital to determine the cause of neck lymphadenopathies. He was diagnosed pathologically by a lymph node biopsy as having peripheral T-cell lymphoma (PTCL). He also had developed eosinophilia and his serum concentration of Interleukin-5 (IL-5) was extremely high. Immunostaining of a resected lymph node revealed that there were lymphoma cells which were stained with anti-IL-5 antibody. After 2 courses of CHOP therapy, the lymphadenopathies and eosinophilia disappeared and the concentration of serum IL-5 was normalized. It was suggested that IL-5 produced by lymphoma cells had induced his eosinophilia.

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A case of recurrent biliary cystadenocarcinoma successfully treated with 5FU/CDDP systemic chemotherapy

Satoshi Iyama, Yasuo Takahashi, Naoaki Shintani, Koshi Fujikawa, Syunichi Ohkubo, Yasushi Sato, Tsutomu Sato, Yasuhiro Sato, Keisuke Ohnuma, Yoshiro Niitsu

Japanese Journal of Gastroenterology ( The Japanese Society of Gastroenterology ) 103 ( 10 ) 1163 - 1168 2006.10

We report a case of biliary cystadenocarcinoma which recurred 41 months postoperatively. A 60-year-old woman was admitted for further examination of multiple metastatic tumors and a large amount of ascites. Systemic administration of 5FU and CDDP caused her CEA level to decrease gradually and abdominal computed tomography revealed considerable reduction of the metastatic tumors and ascites. Since her general condition had improved, chemotherapy was continued in the outpatient clinic.

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De novo CD5-positive diffuse large B-cell lymphoma associated with autoimmune hemolytic anemia presenting as erythroid hypoplasia

KURODA Hiroyuki, MATSUNAGA Takuya, IYAMA Satoshi, TAKIMOTO Rishu, SHIRAO Sayaka, KIDA Masaya, WATANABE Hideki, KONUMA Yu-ichi, HIRAYAMA Yasuo, KOHDA Kyuhei, NIITSU Yoshiro

臨床血液 = The Japanese Journal of Clinical Hematology ( 日本臨床血液学会 ) 47 ( 7 ) 633 - 638 2006.07

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Enteropathy-type T-cell lymphoma with CD8 and CD56 expression

SATO Tsutomu, MATSUNAGA Takuya, IYAMA Satoshi, SAKAI Toshiro, MURASE Kazuyuki, SATO Yasushi, KOBUNE Masayoshi, TAKIMOTO Rishu, KATO Junji, NIITSU Yoshiro

臨床血液 = The Japanese Journal of Clinical Hematology ( 日本臨床血液学会 ) 47 ( 7 ) 645 - 649 2006.07

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A case of metastatic small bowel and gastric cancer from the lung caused intussusception

井山諭, 高橋康雄, 新谷直昭

Japanese journal of cancer clinics ( 篠原出版新社 ) 52 ( 2 ) 77 - 83 2006

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Diagnostic utility of fluorescence in situ hybridization (FISH) in mantle cell lymphoma in leukemic phase

井山諭, 松永卓也, 佐藤勉

Japanese journal of cancer clinics ( 篠原出版新社 ) 52 ( 6 ) 455 - 461 2006

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Successful treatment with oral ribavirin of adenovirus-associated hemophagocytic syndrome in a stem cell transplantation recipient

IYAMA Satoshi, MATSUNAGA Takuya, FUJIMI Akihito, MURASE Kazuyuki, KURIBAYASI Kageaki, SATO Tsutomu, HIRAYAMA Yasuo, SAKAMAKI Sumio, KOHDA Kyuhei, NIITSU Yoshiro

Rinsho Ketsueki ( The Japanese Society of Hematology ) 46 ( 5 ) 363 - 367 2005.05

A 51-year-old woman with severe aplastic anemia underwent allogeneic peripheral blood stem cell transplantation using blood stem cells from an HLA-identical sibling. Adenovirus type 11 hemorrhagic cystitis developed and progressed to nephritis and hemophagocytic syndrome. Oral ribavirin was effective not only for the hemorrhagic cystitis and nephritis but also for the hemophagocytic syndrome. Since therapeutic strategies for adenovirus infection after hematopoietic stem cell transplantation have not been established, we present our case and discuss the therapeutic approach.

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11. 臍帯血移植後にドナー細胞由来の急性骨髄性白血病(AML)を発症した成人T細胞性白血病リンパ腫(ATLL)(日本アフェレシス学会第24回北海道地方会抄録)(<特集>アフェレシスにおけるセイフティーマネジメント)

村瀬和幸, 松永卓也, 栗林景晶, 井山諭, 菊池尚平, 藤見章仁, 新津洋司郎, 古川勝久

日本アフェレシス学会雑誌 ( 日本アフェレシス学会 ) 24 ( 1 ) 121 - 121 2005.02

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A novel treatment for early gastrointestinal carcinoma by ultrasonic endoscopic mucosal stripping

OHTA Hidetoshi, SHINTANI Naoaki, FUJIKAWA Koshi, IYAMA Satoshi, TAKAHASHI Yasuo, NOBUOKA Atsushi, DOI Tadashi, NAKAMURA Tokiko, TAKAYAMA Tetsuji, NATORI Hiroshi

Journal of medical ultrasonics : official journal of the Japan Society of Ultrasonics in Medicine 31 ( 4 ) 141 - 148 2004.12

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免疫療法の進歩 (特別企画がんの最新知識)

佐藤勉, 井山諭, 新津洋司郎

からだの科学 ( 日本評論社 ) ( 238 ) 86 - 91 2004.09

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A case of primary biliary cirrhosis with HLA-DR 8 complicated by polymyositis

SATO Tsutomu, KATO Junji, SATO Yasushi, IYAMA Satoshi, TAKADA Kohichi, OKU Takatomi, TAKAHASHI Sho, MACHIDA Takurou, KOBUNE Masayoshi, MATSUNAGA Takuya, TAKAHASHI Minoru, NIITSU Yoshiro

Kanzo ( The Japan Society of Hepatology ) 44 ( 9 ) 455 - 459 2003.09

症例は64歳, 女性. 皮膚掻痒感, 四肢の筋力低下を主訴として入院した. 血液検査では, 胆道系酵素, 筋原性酵素の上昇を認め, 抗核抗体, 抗ミトコンドリア抗体(AMA), 抗M2抗体が陽性であった. 肝生検では慢性非化膿性破壊性胆管炎を, 筋生検では筋線維の大小不同および円形萎縮を認めた. 原発性胆汁性肝硬変(PBC)と多発性筋炎の合併と診断し, ウルソデオキシコール酸およびプレドニゾロンを投与したところ, 検査所見と自覚症状は改善した. PBCは稀に多発性筋炎を合併するが, その機序としてAMAによる筋組織のミトコンドリア障害が想定されている. 本症例でも電子顕微鏡観察において, 特徴的なミトコンドリアの増加が観察された. 更に, 多発性筋炎の発症要因とされるHLA-DR 8が陽性であった. このことは, 患者の免疫学的な背景も多発性筋炎の合併に関与する可能性を示唆すると考えられた.

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A case of cholangiocellular carcinoma effectively treated with combination chemotherapy of gemcitabine and 5-FU

TAKANASHI Kunihiro, HOMMA Hisato, MEZAWA Shin-ichi, DOI Tadashi, AKIYAMA Takehide, HIRATA Ken-ichiro, IYAMA Satoshi

Kanzo ( The Japan Society of Hepatology ) 44 ( 6 ) 301 - 306 2003.06

症例は78歳, 女性. 主訴は腹部不快感. 肝S2/3に63×44mmの腫瘤と腫瘤末梢側の肝内胆管の拡張, 腹部リンパ節の腫大を認めた. 各種画像診断及び針生検にて胆管細胞癌と診断. Gemcitabine, 5-FU併用化学療法にて腫瘍はほとんど同定できないまでに縮小し, リンパ節腫大も消失, 治療効果判定はPRであった. 切除不能胆管細胞癌の予後は不良であるが, 本療法は有効な治療選択の一つになり得ると考えられた.

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A case of polyarteritis nodosa treated by methotrexate: Follow-up study of hepatic arteriography

Kunihiro Takanashi, Hisato Homma, Shin-Ichi Mezawa, Tadashi Doi, Takehide Akiyama, Ken Murakami, Koichi Takada, Takehiro Kukitsu, Kazuyuki Murase, Satoshi Iyama, Koji Miyanishi, Yoshiro Niitsu

Acta Hepatologica Japonica ( Japan Society of Hepatology ) 44 ( 12 ) 649 - 655 2003

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Successful treatment of advanced peripheral T-cell lymphoma with an angiocentric growth pattern complicated with hemophagocytic syndrome by high-dose chemotherapy and autologous peripheral blood stem cell transplantation

T Sato, K Kogawa, S Iyama, D Kobayashi, Y Sato, K Kuribayashi, K Takada, S Hagiwara, T Oku, S Takahashi, T Matsunaga, M Takahashi, T Terui, J Kato, Y Niitsu

ANNALS OF HEMATOLOGY ( SPRINGER-VERLAG ) 81 ( 12 ) 739 - 743 2002.12

Peripheral T-cell lymphomas (PTCL) account for about 10% of all lymphomas in Western countries, respond poorly to therapy, and have short survival with no sustained remission. Furthermore, the complication of hemophagocytic syndrome (HPS) sometimes makes the prognosis of this disease extremely worse. We report here a case of PTCL with an angiocentric growth pattern complicated with HPS successfully treated by high-dose chemotherapy and autologous peripheral blood stem cell transplantation. Our case suggests this approach is an excellent candidate for the treatment of this disease.

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<Abstract of Published Report>Treatment of murine collagen-induced arthritis by ex vivo extracellular superoxide dismutase gene transger.

IYAMA Satoshi, OKAMOTO Tetsuro, SATO Tsutomu, YAMAUCHI Naofumi, SATO Yasushi, SASAKI Katsunori, TAKAHASHI Minoru, TANAKA Maki, ADACHI Tetsuo, KOGAWA Katsuhisa, KATO Junji, SAKAMAKI Sumio, NIITSU Yoshiro

The annual proceedings of Gifu College of Pharmacy ( Gifu Pharmaceutical University ) 51 82 - 82 2002.06

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