Research Experience 【 display / non-display 】

Research Experience 【 display / non-display 】

• 2012

  　

  　

  Sapporo Medical University   School of Medicine   助教

  助教

Research Areas 【 display / non-display 】

Research Areas 【 display / non-display 】

• Life sciences   Digestive surgery  

Affiliation 【 display / non-display 】

Affiliation 【 display / non-display 】

• Sapporo Medical University   医学部   講師  

Research Interests 【 display / non-display 】

Research Interests 【 display / non-display 】

• 組織肝細胞

• 肝臓外科学

• 肝再生

• 組織幹細胞

• 細胞移植

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Papers 【 display / non-display 】

Papers 【 display / non-display 】

• Asialoglycoprotein receptor scintigraphy with Tc-99m-galactosyl human serum albumin (Tc-99m-GSA) as an early predictor of survival in acute liver failure

  H. Tatsumi, Y. Masuda, H. Imaizumi, S. Yoshida, K. Goto, N. Yama, T. Mizuguchi, K. Hirata

  ANAESTHESIA AND INTENSIVE CARE ( AUSTRALIAN SOC ANAESTHETISTS )  41 ( 4 ) 523 - 528  2013.07  [Refereed]

  　View Summary

  This study evaluated the usefulness of asialoglycoprotein receptor scintigraphy with Tc-99m-galactosyl human serum albumin (Tc-99m-GSA scintigraphy) as an early predictor for prognosis of acute liver failure. Forty-eight patients with acute liver failure and without a past history of chronic liver disease were enrolled. Patients were divided into survival and non-survival groups by 28-day mortality. Tc-99m-GSA scintigraphy to detect uptake ratio of the heart at 15 minutes to that at three minutes (HH15) and uptake ratio of the liver at 15 minutes to the liver plus the heart at 15 minutes (LHL15), and measurements of serum total bilirubin, hepatocyte growth factor and prothrombin time were performed immediately after the diagnosis of acute liver failure. Areas under the receiver operating characteristic curves were used to compare the prognostic ability of total bilirubin, hepatocyte growth factor, prothrombin time, HH15 ratio, LHL15 ratio and the model for end-stage liver disease score. Clinical characteristics of patients in the survival group (n=20) and in the non-survival group (n=28) Were not significantly different. HH15 and LHL15 uptake ratios in the survival group were 0.670 and 0.875 and they were significantly lower and higher than those in the non-survival group, respectively. All patients with LHL15 <0.760 died, and the area under the receiver operating characteristic curve for LHL15 were significantly larger than the areas under the receiver operating characteristic curves of serum variables and model for end-stage liver disease score. In summary, in patients with acute liver failure without chronic liver disease, HH15 and LHL15 of Tc-99m-GSA scintigraphy are more useful variables in predicting prognosis than serum variables and model for end-stage liver disease score.

  PubMed

• 腎被膜原発平滑筋腫の1例

  北川 未央, 玉川 光春, 兵頭 秀樹, 兵頭 かずさ, 山 直也, 河合 有里子, 佐藤 大志, 荒谷 和紀, 小野寺 麻希, 笠原 理子, 鷲尾 嘉一, 斎藤 正人, 晴山 雅人, 舛森 直哉, 塚本 泰司

  Japanese Journal of Radiology ( (公社)日本医学放射線学会 )  31 ( Suppl.I ) 7 - 7  2013.02

• MRIによる前立腺癌の浸潤進展度の評価

  荒谷 和紀, 玉川 光春, 兵頭 秀樹, 兵頭 かずさ, 山 直也, 河合 有里子, 佐藤 大志, 小野寺 麻希, 笠原 理子, 鷲尾 嘉一, 斎藤 正人, 北川 未央, 晴山 雅人, 田中 俊明, 舛森 直哉, 塚本 泰司

  Japanese Journal of Radiology ( (公社)日本医学放射線学会 )  31 ( Suppl.I ) 7 - 7  2013.02

• A retrospective study on the transition of radiation dose rate and iodine distribution in patients with I-131-treated well-differentiated thyroid cancer to improve bed control shorten isolation periods

  Naoya Yama, Koh-ichi Sakata, Hideki Hyodoh, Mitsuharu Tamakawa, Masato Hareyama

  ANNALS OF NUCLEAR MEDICINE ( SPRINGER )  26 ( 5 ) 390 - 396  2012.06  [Refereed]

  　View Summary

  To evaluate for how long patients should be isolated after I-131 treatment for thyroid cancer according to the guidelines issued by the Japanese Ministry of Welfare. We reviewed 92 therapies performed in 76 patients who were administered I-131 at our hospital from July 2007 to September 2009. Fifty-six patients were given 2220 or 2960 MBq I-131 at the first therapy, and 29 patients underwent 36 repeated therapies using 2960, 3700, 5550 or 7400 MBq I-131. We surveyed radioactivity for a 1 cm dose equivalent rate at 1 m intervals at 30 and 48 h after administration of I-131, obtained planar scintigrams at 48 h, and surveyed radioactivity repeatedly until it fell to under 30 mu Sv/h. The radioactivity was under 30 mu Sv/h at 30 h in 51 out of 92 cases (55%). Among the remaining 41 (45%) cases, 27 (29%) and 32 (35%) cases showed decreased radioactivity under 30 mu Sv/h at 48 and 72 h, respectively, and it remained higher than 30 mu Sv/h at 72 h in another 9 cases (10%). In 5 (38%) of the 13 cases with bone metastasis, the radioactivity remained over 30 mu Sv/h after 72 h, and scintigrams showed strong accumulation in bone metastases. Among the 27 cases demonstrating below 30 mu Sv/h at 48 h, 26 showed radioactivity being below 50 mu Sv/h at 30 h, while it was above 50 mu Sv/h at 30 h in all 14 cases which demonstrated above 30 mu Sv/h at 48 h. We compared the radioactivity levels of 27 cases under 30 mu Sv/h at 48 h and 14 cases over 30 mu Sv/h at 48 h using a cutoff value of under 50 mu Sv/h at 30 h to release patient at 48 h, the positive predictive value and negative predictive value were 100 and 93%, respectively, and radioactivity was found to differ significantly (P < 0.001). To predict external radiation levels at 48 h, it is helpful to consider external radiation levels at 30 h after treatment. Consideration of intracellular uptake in thyroid cancer, especially in cases of bone metastases, digestive tract function, and renal function, is important for predicting isolated period.

  DOI PubMed

• 喉頭癌の軟骨浸潤の評価

  北川 未央, 玉川 光春, 兵頭 秀樹, 兵頭 かずさ, 山 直也, 佐藤 大志, 河合 友里子, 晴山 雅人, 畠中 正光, 長谷川 匡

  日本医学放射線学会学術集会抄録集 ( (公社)日本医学放射線学会 )  71回   S339 - S339  2012.02

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Misc 【 display / non-display 】

Misc 【 display / non-display 】

• Radiographic Examinations for Severe Sepsis/Septic Shock Patients

  池田 寿昭, 鈴木 泰, 山 直也

  ICUとCCU = Japanese journal of intensive care medicine : 集中治療医学 ( 医学図書出版 )  36 ( 11 ) 987 - 990  2012.11

  CiNii

• A case of Churg-Strauss syndrome complicated with diffuse alveolar hemorrhage that was treated by plasma exchange

  Yoshida Shin-ichiro, Tanabe Miyuki, Masuda Yoshiki, Imaizumi Hitoshi, Yama Naoya, Tatsumi Hiroomi, Goto Kyoko, Asai Yasufumi

  Journal of the Japanese Society of Intensive Care Medicine ( The Japanese Society of Intensive Care Medicine )  19 ( 4 ) 623 - 627  2012

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  We report a case of severe Churg-Strauss syndrome (CSS) complicated with diffuse alveolar hemorrhage. A 47-year-old female patient complicated with diffuse alveolar hemorrhage, disseminated intravascular coagulation and intracerebral hemorrhage was admitted to our ICU due to acute respiratory failure. As a result of several examinations, the patient was first diagnosed as having CSS. After treatment with high-dose steroid under mechanical ventilation, acute respiratory failure with diffuse alveolar hemorrhage was improved. However, when the steroid dose was reduced, diffuse alveolar hemorrhage recurred. Therefore, plasma exchange therapy was performed and resulted in dramatic improvement of recurrent diffuse alveolar hemorrhage, and the patient was weaned from mechanical ventilation and survived. Generally, immunosupressant agents are recommended for treatment of CSS when there is no response to steroid therapy. However, it has been demonstrated that the main cause of death in CSS patients with diffuse alveolar hemorrhage is sepsis. Therefore, plasma exchange rather than immunosuppressant therapy is a useful option for treatment of severe CSS to prevent complication with severe infection.

  DOI CiNii

• Change of radioactivity of aqueous solution of I-131 with evaporation

  山 直也, 坂田 耕一, 晴山 雅人

  放射線防護医療 ( 放射線防護医療研究会 )  ( 7 ) 34 - 36  2011.12

  CiNii

• Attenuation of the radiation dose rate in patients treated with I-131

  山 直也, 浅沼 治, 佐藤 香織

  放射線防護医療 ( 放射線防護医療研究会 )  ( 6 ) 34 - 36  2010.12

  CiNii

• Management of the radiation dose rate and iodine distribution in patients treated with I-131

  山 直也, 浅沼 治, 佐藤 香織

  放射線防護医療 ( 放射線防護医療研究会 )  ( 5 ) 29 - 31  2009.12

  CiNii

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Research Projects 【 display / non-display 】

Research Projects 【 display / non-display 】

• Evaluation of rectal cancer aggressiveness based on conductivity imaging

  Grant-in-Aid for Scientific Research (C)

  Project Year :

  2018.04

  -

  2023.03

   

  畠中 正光, 山 直也, 小野寺 麻希, 杉田 真太朗, 西舘 敏彦

  　View Summary

  ドイツの共同研究者であるUlrich博士との連携が十分ではなく、現在のところ解析が可能であった10例のconductivity imagesに対して、LIFEx Version7.0を用い、Gray level=64、データ範囲±3δの設定条件で行ったtexture解析結果からは以下の結果が示された。 リンパ節転移巣の有無に関して、Gray-Level Co-Occurence Matrix Contrast： p=0.006、Gray-Level Co-Occurence Matrix Correlation : p=0.027、病変の進行度に関して（Stage 1,2 versus Stage 3,4）も同様にGray-Level Co-Occurence Matrix Contrast： p=0.006、Gray-Level Co-Occurence Matrix Correlation : p=0.027、 また有意とは言えなかったが、病変分化度（Well differentiated adenocarcinoma versus Moderate differentiated adenocarcinoma）に関してGray Level Run Length High Gray Level Run Emphasis: p=0.086、リンパ節転移の有無に関して、最大値：p=0.093、25％値：p=0.093、同様に病変の進行度に関して（Stage 1,2 versus Stage 3,4）、最大値：p=0.093、25％値：p=0.093の結果が得られ解析症例数が増加すると、特にリンパ節転移の有無に関してある程度予測可能となることが期待された。

• Establishment of early detection and treatment assessment of pulmonary hypertension by PC-cine MRI

  Grant-in-Aid for Scientific Research (C)

  Project Year :

  2016.04

  -

  2019.03

   

  Murayamma Sadayuki

  　View Summary

  Phase contrast MRI (PC-MRI) can determine pulmonary hemodynamics noninvasively. Pulmonary hypertension causes changes in pulmonary hemodynamics and is a factor for acute exacerbation and death in interstitial lung diseases (ILD). The purpose of this study was to determine the association between pulmonary hemodynamics measured by PC-MRI and episodes of acute exacerbations and death in patients with ILD related pulmonary hypertension. Reduction in right cardiac output, as detected by PC-MRI, was associated with acute exacerbation and increased mortality in ILD. MR examination to detect right ventricular dysfunction is useful for predicting the poor prognosis in fibrotic ILD patients, even if they are not combined with pulmonary hypertension.

• Predicting treatment effect and prognosis by using IVIM

  Grant-in-Aid for Scientific Research (C)

  Project Year :

  2014.04

  -

  2017.03

   

  Hatakenaka Masmaitsu

  　View Summary

  In total, 28 patients with head and neck cancer who were treated with (chemo)radiotherapy were enrolled in the present study. However, 8 patients were excluded due to poor image quality and/or inadequate clinical data. Further, patients with nasopharyngeal cancer were excluded because its D is lower and sensitive to chemoradiotherapy. Finally, 10 patients were statistically analyzed. The pre-treatment D value for 6 patients without recurrence was 0.640±0.168 mm2/s and that for 4 ones with recurrence was 0.921±0.204 mm2/s and statistically significant difference was observed (p<0.05). The ratio of D value increase at 10Gy was 0.350±0.533 without recurrence and 0.04±0.174 with recurrence but statistical significance was not observed. F(perfusion fraction) and D*(perfusion) derived from IVIM method show wide variation. Signal intensity at b=25 s/mm2 was lower than that at b=50 s/mm2 in some cases. Thus, F and D* were not analyzed.

• Clinical and Basic Researches of Hepatic Stem Cells onLiver Regeneration as Defense Mechanism.

  基盤研究(B)

  Project Year :

  2010

  -

  2012

   

  Koichi HIRATA, Toshihiro MITAKA, Toru MIZUGUCHI, Yukio NAKAMURA, Makoto MEGURO, Masaki KAWAMOTO, Naoya YAMA, Hiroomi TATSUMI, Shigenori OTA, Masafumi IMAMURA, Hiroshi YAMAGUCHI, Takashi KOJIMA, Norimasa SAWADA

  Authorship： Collaborating Investigator(s) (not designated on Grant-in-Aid)

  　View Summary

  We have achieved the results by the clinical and basic studies.【Study 1】We developed a rat model of acute liver failure after 2/3 partial hepatectomy (PH) for non-alcoholic steatohepatitis (NASH)-related cirrhosis. The mechanism by which HT improved the survival of the model rats was examined in short- and long-term investigations. Overall survival was significantly longer in the HT group than the non-HT group (7-day survival rates: 46.7% and 7.7%, respectively). Preoperative HT might improve the survival of rats with NASH-related cirrhosis after PH by preventing the host hepatocytes from accelerating their growth and falling into apoptosis. 【Study 2】We developed software to calculate the pixels of interest in the area between the hepatic and heart curves (ABC) of 99mTc-galactocyl human serum albumin (GSA) scintigraphy. The area under the receiver operating characteristic curve (AUC) was calculated for evaluation of Child-Pugh score grade B (Child B), pathological chronic hepatitis (CH), and liver cirrhosis (LC). We developed a novel liver functional indicator, the ABC, to count radioactivity in sequence.