Updated on 2026/02/21

写真a

 
YAMA Naoya
 
Organization
School of Medicine Department of Diagnostic Radiology Associate Professor
Title
Associate Professor
Homepage
http://kaken.nii.ac.jp/d/r/20404709.ja.html
External link

Research Interests

  • 細胞移植

  • 組織肝細胞

  • 肝予備能

  • 肝再生

  • 肝臓外科学

  • 組織幹細胞

  • 肝予備機能

Research Areas

  • Life Science / Digestive surgery

Research History

  • Sapporo Medical University   School of Medicine   Assistant Professor

    2012

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Papers

  • Olfactory Bulb Volume and Function Recovery in Eosinophilic Chronic Rhinosinusitis. International journal

    Keisuke Yamamoto, Masaki Abukawa, Tsuyoshi Okuni, Mitsuhiro Nakanishi, Yuki Sakurai, Naoya Yama, Noriko Ogasawara, Ryuta Kamekura, Kenichi Takano

    The Laryngoscope   2026.2

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    OBJECTIVE: To evaluate perioperative changes in olfactory bulb volume (OBV) and olfactory function in patients with eosinophilic chronic rhinosinusitis (ECRS) using 3T magnetic resonance imaging (MRI) with fast imaging employing steady-state acquisition (FIESTA) sequence and to assess their associations. METHODS: This single-center, retrospective observational study included 32 patients with ECRS who underwent functional endoscopic sinus surgery. Olfactory function was assessed pre- and postoperatively using the Alinamin test, T&T olfactometer, Open Essence (OE), Odor Stick Identification Test for Japanese (OSIT-J), Visual Analog Scale (VAS), and Self-Assessment Olfactory Questionnaire (SAOQ). OBV was manually measured from FIESTA images. Logistic regression was used to identify preoperative predictors of OBV change. RESULTS: Postoperative OE, OSIT-J, VAS, and SAOQ scores improved significantly. Mean OBV increased by 10.3% postoperatively, although not statistically significant (p = 0.095). OBV change correlated with improvements in olfactory identification (OE: r = 0.404, p = 0.022; OSIT-J: r = 0.402, p = 0.022), which should be interpreted as exploratory. Multivariate analysis revealed that longer odor duration on the Alinamin test (≥ 50 s) and higher SAOQ scores predicted smaller OBV increases. CONCLUSION: OBV measurement using 3T MRI with FIESTA may provide a structural correlate of olfactory changes in ECRS. The observed correlation between OBV changes and olfactory identification suggests a potential relationship with postoperative functional recovery.

    DOI： 10.1002/lary.70415

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  • Exploring a Subpopulation of MASLD Associated With New Onset of CKD Using Supervised Clustering Techniques. International journal

    Itaru Hosaka, Marenao Tanaka, Tatsuya Sato, Yukinori Akiyama, Keitaro Nishizawa, Rie Matsumori, Hiroki Aida, Wataru Kawaharata, Kei Nakata, Koki Abe, Toru Suzuki, Hidemichi Kouzu, Naoya Yama, Nagisa Hanawa, Masato Furuhashi

    Hepatology research : the official journal of the Japan Society of Hepatology   2026.1

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    AIMS: Metabolic dysfunction-associated steatotic liver disease (MASLD) is characterized by the presence of hepatic steatosis and at least one of five cardiometabolic risk factors, leading to the development of cardiovascular-kidney-metabolic syndrome including chronic kidney disease (CKD). However, the impact of heterogeneity of MASLD on new onset of CKD remains unclear. We explored the relationship between subgroups of MASLD divided by using a machine learning (ML) model called supervised clustering and the development of CKD during a 10-year follow-up period. METHODS: A total of 12,168 Japanese subjects (men/women: 7927/4,241 and mean age: 48 years) who received annual health examinations including abdominal ultrasonography were recruited. RESULTS: Using the supervised clustering by SHapley Additive exPlanations (SHAP) and uniform manifold approximation and projection (UMAP) for steatotic liver diseases, 10 subclusters including 3 distinctive subgroups of MASLD were detected by a Gaussian mixture model. Kaplan-Meier survival curve analysis showed a significant difference in the cumulative incidence for new onset of CKD among the 3 subgroups of MASLD. Among the MASLD subclusters, an obese subgroup with an atherogenic profile of serum lipids as well as high levels of fatty liver index and uric acid was the worst subcluster for the development of CKD in individuals with MASLD. CONCLUSIONS: The supervised clustering of MASLD using a SHAP-converted matrix and UMAP reveals phenotypically distinct subpopulations that improved risk stratification for new onset of CKD. An obese subgroup with atherogenic lipid profiles and hyperuricemia in MASLD is associated with an increased risk for the development of CKD.

    DOI： 10.1111/hepr.70127

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  • The Effectiveness of Lesion Detection for Immunoglobulin G4-Related Kidney Diseases by Diffusion-Weighted Imaging. International journal

    Hidenori Amaike, Masatoshi Kanda, Hirotsugu Yamazaki, Koki Nakamura, Li Ma, Ken Nagahata, Hiroyuki Nakamura, Arata Osanami, Naoya Yama, Masamitsu Hatakenaka, Masato Furuhashi, Hiroki Takahashi

    Nephron   150 ( 1 )   1 - 11   2026

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    OBJECTIVES: The aim of the study was to compare the efficacy of magnetic resonance imaging (MRI) with that of plain or contrast-enhanced computed tomography (CT) in the detection of renal parenchymal and pelvic lesions of immunoglobulin G4-related kidney disease (IgG4-RKD). METHODS: Patients with IgG4-RKD and controls, who performed plain, contrast-enhanced CT and MRI around the kidney region in our hospital, were enrolled. The diagnosis of IgG4-RKD was made by definite cases of IgG4-RKD diagnostic criteria in 2020. Five blinded observers independently assessed image datasets by confidence scores to assess diagnostic accuracy, sensitivity, specificity, areas under the receiver operating characteristic curve (AUROC), and Cronbach's alpha coefficient. RESULTS: A total of 31 patients were included in the study. Fourteen (45.2%) had IgG4-RKD. Five patients with IgG4-RKD had parenchymal lesions, 5 had renal pelvic lesions, and 4 had both. In the parenchymal lesions, there was no significant difference in diagnostic performance between contrast-enhanced CT and diffusion-weighted imaging (DWI)-b800. The AUROC and sensitivity were higher in DWI-b800 than in plain CT (p < 0.05). Cronbach's alpha coefficient was 0.44 for plain CT and over 0.80 for contrast-enhanced CT and DWI-b800. In the pelvic lesions, there were fewer differences in the performance among each sequence. Cronbach's alpha coefficient was over 0.80 for plain CT, contrast-enhanced CT, and DWI-b800. CONCLUSION: Plain MRI, especially in DWI-b800, can effectively detect renal parenchymal lesions in IgG4-RKD. In cases where the use of a contrast agent of CT is difficult, DWI-b800 can be an alternative for the screening of IgG4-RKD.

    DOI： 10.1159/000547628

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  • Screening for lung fibrosis using serum surfactant protein-D, KL-6, and a deep learning algorithm on chest radiographs: a prospective observational study. International journal

    Hirotaka Nishikiori, Naoya Yama, Kenichi Hirota, Yuki Mori, Ippei Neriai, Haruka Takenaka, Atsushi Saito, Mamoru Takahashi, Koji Kuronuma, Shinichiro Ueda, Masamitsu Hatakenaka, Hirofumi Chiba

    BMC pulmonary medicine   26 ( 1 )   22 - 22   2025.12

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    BACKGROUND: Early identification of lung fibrosis remains difficult. In Japan, the serum biomarkers surfactant protein-D (SP-D) and KL-6 are commonly used to monitor interstitial lung diseases (ILD) in clinical practice, but their potential role in the early detection of lung fibrosis has not yet been fully clarified. Although chest radiography is also considered a possible tool for identifying subclinical pulmonary fibrosis, detecting early-stage disease remains challenging. A deep learning-based software, BMAX, was recently developed to identify fibrosing ILD on chest radiographs. Its capability to detect lung fibrosis in a health-checkup setting requires validation. METHODS: Study participants were randomly recruited from individuals undergoing routine health examinations. All participants underwent chest radiography and serum SP-D and KL-6 testing. Those with elevated biomarker levels (≥ 110 ng/mL for SP-D and ≥ 500 IU/mL for KL-6) or radiographic abnormalities were advised to undergo further evaluation with chest computed tomography (CT). Lung fibrosis on CT was assessed independently by one pulmonologist and one thoracic radiologist. BMAX assigned a confidence score for lung fibrosis (ranging from 0 to 1) on each radiograph. In participants who underwent CT, the sensitivity and specificity of BMAX (using a confidence score > 0.3 as the threshold), SP-D, and KL-6 for detecting lung fibrosis were evaluated. RESULTS: Among the 2,751 individuals enrolled, 228 were recommended for CT, and 81 underwent the scan. Lung fibrosis was identified on chest CT in 8 of the 81 participants. The positivity rates for SP-D, KL-6, and BMAX (confidence score > 0.3) were 5.9%, 2.4%, and 5.9%, respectively. SP-D showed a sensitivity of 1.000 and a specificity of 0.315, while KL-6 showed a sensitivity of 0.750 and a specificity of 0.753. BMAX demonstrated a sensitivity of 1.000 and a specificity of 0.904. CONCLUSIONS: SP-D and KL-6 may be useful screening biomarkers for lung fibrosis in health checkup settings, offering high sensitivity and moderate positivity rates. BMAX also appears promising as a standalone screening tool for detecting lung fibrosis on chest radiographs.

    DOI： 10.1186/s12890-025-04062-5

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  • An Apparent Association of Metabolic Dysfunction-Associated Steatotic Liver Disease with High Levels of Estimated Small Dense LDL Cholesterol in a Japanese Population.

    Rie Matsumori, Marenao Tanaka, Tatsuya Sato, Yukinori Akiyama, Itaru Hosaka, Kei Nakata, Wataru Kawaharata, Hiroki Aida, Keitaro Nishizawa, Hidemichi Kouzu, Naoya Yama, Nagisa Hanawa, Masato Furuhashi

    Journal of atherosclerosis and thrombosis   2025.11

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    AIM: Metabolic dysfunction-associated steatotic liver disease (MASLD) is associated with an increased risk of atherosclerotic cardiovascular disease (ASCVD). Although small dense low-density lipoprotein cholesterol (sdLDL-C) is a highly atherogenic lipid fraction, the association of the sdLDL-C level with MASLD and other steatotic liver disease (SLD) subcategories remain unclear. We investigated the association between various SLDs and the sdLDL-C level calculated by Sampson's equation. METHODS: A total of 15,734 Japanese participants (men/women: 10,228/5,506, mean age: 49±9 years) who underwent annual health examinations including abdominal ultrasonography were recruited after the exclusion of subjects with triglycerides ≥ 800 mg/dL. RESULTS: Among SLD subcategories including MASLD, MASLD with increased alcohol consumption (MetALD) and alcohol-associated liver disease (ALD), the mean levels of sdLDL-C and non-high-density lipoprotein cholesterol (non-HDL-C) were the highest in participants with MASLD. Triglyceride levels were significantly lower in participants with MASLD than in those with MetALD and those with ALD. After adjustment for age, sex, body mass index, current smoking and alcohol drinking habits, treatment of hypertension, diabetes and dyslipidemia, and triglyceride level, MASLD and MetALD were independently associated with sdLDL-C level, and the association was stronger in MASLD than in other SLD subcategories. The sdLDL-C level was also independently associated with each SLD subcategory after adjustment for the same covariates. The addition of sdLDL-C to traditional risk factors significantly improved the discriminatory capacity for the presence of MASLD in comparison to the addition of non-HDL-C. CONCLUSION: MASLD is independently associated with elevated estimated sdLDL-C levels in Japanese individuals, leading to an increased risk of ASCVD.

    DOI： 10.5551/jat.65939

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  • The health stage of cardiovascular-kidney-metabolic (CKM) syndrome is useful for predicting all-cause mortality in patients with type 2 diabetes: a cohort study in a period prior to the standard use of recent pharmacotherapy. International journal

    Keitaro Nishizawa, Marenao Tanaka, Tatsuya Sato, Tomohito Gohda, Nozomu Kamei, Maki Murakoshi, Yukinori Akiyama, Wataru Kawaharata, Hiroki Aida, Hidemichi Kouzu, Naoya Yama, Mitsunobu Kubota, Michiyoshi Sanuki, Yusuke Suzuki, Masato Furuhashi

    Journal of diabetes and its complications   39 ( 10 )   109146 - 109146   2025.10

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    AIM: Cardiovascular-kidney-metabolic (CKM) syndrome is a recently defined systemic condition linking cardiovascular disease, chronic kidney disease and metabolic disorders including type 2 diabetes (T2D). Although the CKM staging has been proposed for integrated risk assessment, its association with all-cause mortality in patients with T2D remains unclear. We investigated the prognosis in patients with T2D assigned by the CKM health stage. METHODS: A total of 632 Japanese patients with T2D were enrolled. The primary endpoint was all-cause death. RESULTS: The numbers of the recruited patients with stages 2, 3 and 4 were 353 (55.9 %), 116 (18.3 %) and 163 (25.8 %), respectively. During a median follow-up of 64 months (35,327 person-months), 62 patients (9.8 %) died. Kaplan-Meier survival curves analysis showed significant differences in cumulative mortality among CKM health stages (log-rank test: P < 0.001) with higher cumulative mortality in stages 3 and 4 than in stage 2. Multivariable Cox proportional hazard models after adjustment of age, sex, body mass index, current smoking habit, cancer, relevant medications and hemoglobin A1c showed that adjusted hazard ratios (HRs) [95 % confidence intervals] for all-cause death were significantly higher in patients with stages 3 (2.25[1.08-4.69]) and those with stage 4 (2.87[1.41-5.84]) than in those with stage 2 as the reference. After additional adjustment of N-terminal pro-brain natriuretic peptide and estimated glomerular filtration rate among definition criteria for staging, the association of stages with all-cause death remained statistically significant in only stage 4 (2.16[1.02-4.56]). CONCLUSION: The CKM health staging is useful for predicting all-cause mortality in Japanese patients with T2D.

    DOI： 10.1016/j.jdiacomp.2025.109146

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  • Blood-pool SUV analysis of 99mTc-galactosyl human serum albumin (99mTc-GSA) normalized by blood volume for prediction of short-term survival in severe liver failure: preliminary report.

    Naoya Yama, Hiroomi Tatsumi, Masayuki Akatsuka, Masamitsu Hatakenaka

    Annals of nuclear medicine   39 ( 1 )   58 - 67   2025.1

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    PURPOSE: This study evaluated the usefulness of SUV analysis of 99mTc-galactosyl human serum albumin (99mTc-GSA) scintigraphy including SUV analysis of the cardiac blood pool normalized by blood volume as a predictor of short-term survival in severe liver failure. PATIENTS AND METHODS: We enrolled 24 patients with severe liver failure who underwent 99mTc-GSA scintigraphy and were admitted to the intensive care unit. Patients were divided into survival and non-survival groups at 7, 14, and 28 days from the performance of 99mTc-GSA scintigraphy. From SPECT images we calculated SUVs of the cardiac blood pool, performing normalization for body weight, lean body weight, Japanese lean body weight, and blood volume and we calculated SUVs of the liver, normalizing by body weight, lean body weight, and Japanese lean body weight. We also calculated the uptake ratio of the heart at 15 min to that at 3 min (HH15) and the uptake ratio of the liver at 15 min to the liver plus the heart at 15 min (LHL15) from planar images of 99mTc-GSA scintigraphy. RESULTS: There were significant differences between the 7 day survival and non-survival groups for all SUVs of the heart and the liver and HH15, for 14 day survival groups in SUVs of the heart normalized by Japanese lean body weight and blood volume, and no significant differences between 28 day survival groups for any SUVs, HH15, or LHL15. Although the difference was not significant, SUV analysis of the heart normalized by blood volume showed the highest value for the area under the receiver-operating-characteristics curve for both 7 day and 14 day survival. CONCLUSION: SUV analysis of 99mTc-GSA including SUV analysis of cardiac blood pool normalized by blood volume is of value for prediction of short-term survival in cases with severe liver failure.

    DOI： 10.1007/s12149-024-01975-9

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  • Correlation between normally aerated lung and respiratory system compliance at clinical high positive end-expiratory pressure in patients with COVID-19. International journal

    Keishi Ogura, Ryuichi Nakayama, Naofumi Bunya, Shinshu Katayama, Naoya Yama, Yuya Goto, Keigo Sawamoto, Shuji Uemura, Eichi Narimatsu

    Scientific reports   14 ( 1 )   14477 - 14477   2024.6

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    Normally aerated lung tissue on computed tomography (CT) is correlated with static respiratory system compliance (Crs) at zero end-expiratory pressure. In clinical practice, however, patients with acute respiratory failure are often managed using elevated PEEP levels. No study has validated the relationship between lung volume and tissue and Crs at the applied positive end-expiratory pressure (PEEP). Therefore, this study aimed to demonstrate the relationship between lung volume and tissue on CT and Crs during the application of PEEP for the clinical management of patients with acute respiratory distress syndrome due to COVID-19. Additionally, as a secondary outcome, the study aimed to evaluate the relationship between CT characteristics and Crs, considering recruitability using the recruitment-to-inflation ratio (R/I ratio). We analyzed the CT and respiratory mechanics data of 30 patients with COVID-19 who were mechanically ventilated. The CT images were acquired during mechanical ventilation at PEEP level of 15 cmH2O and were quantitatively analyzed using Synapse Vincent system version 6.4 (Fujifilm Corporation, Tokyo, Japan). Recruitability was stratified into two groups, high and low recruitability, based on the median R/I ratio of our study population. Thirty patients were included in the analysis with the median R/I ratio of 0.71. A significant correlation was observed between Crs at the applied PEEP (median 15 [interquartile range (IQR) 12.2, 15.8]) and the normally aerated lung volume (r = 0.70 [95% CI 0.46-0.85], P < 0.001) and tissue (r = 0.70 [95% CI 0.46-0.85], P < 0.001). Multivariable linear regression revealed that recruitability (Coefficient = - 390.9 [95% CI - 725.0 to - 56.8], P = 0.024) and Crs (Coefficient = 48.9 [95% CI 32.6-65.2], P < 0.001) were significantly associated with normally aerated lung volume (R-squared: 0.58). In this study, Crs at the applied PEEP was significantly correlated with normally aerated lung volume and tissue on CT. Moreover, recruitability indicated by the R/I ratio and Crs were significantly associated with the normally aerated lung volume. This research underscores the significance of Crs at the applied PEEP as a bedside-measurable parameter and sheds new light on the link between recruitability and normally aerated lung.

    DOI： 10.1038/s41598-024-64622-3

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  • Importance of Diagnostic Imaging Training for Intensivists: Lessons Learned From a Case. International journal

    Masayuki Akatsuka, Akira Hasebe, Naoya Yama

    Cureus   16 ( 3 )   e55779   2024.3

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    Intensive care physicians are tasked with managing patients with complex organ disorders, necessitating a broad skill set and ongoing education. While simulation training often focuses on equipment handling, this case report highlights a critical instance of acute aortic dissection initially missed on imaging during intensive care unit (ICU) admission. An 86-year-old woman with multiple comorbidities presented with respiratory symptoms and electrolyte imbalances, ultimately requiring ICU admission. Despite initial inconclusive imaging and treatment for suspected conditions, further evaluation revealed a dissecting aneurysm of the descending aorta. This case underscores the importance of thorough diagnostic evaluation and ongoing vigilance, especially in older adults with multiple health conditions. It emphasizes the need for comprehensive education, including proactive training in image diagnosis, to recognize diverse medical presentations and potential complications. This case serves as a reminder of the evolving challenges in critical care and the necessity for continuous education and adaptability to ensure optimal patient outcomes.

    DOI： 10.7759/cureus.55779

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  • Bronchiolitis Obliterans With Recurrent Pneumothorax After Allogeneic Bone Marrow Transplantation. International journal

    Masayuki Akatsuka, Naoya Yama

    Cureus   15 ( 10 )   e46633   2023.10

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    Bronchiolitis obliterans syndrome (BOS) is a non-infectious pulmonary complication that can occur in patients who have undergone allogeneic bone marrow transplantation (BMT). BOS is characterized by the irreversible narrowing and obstruction of bronchi, resulting in severe respiratory distress and poor outcomes. This case report focuses on the complex management of a patient with a multifaceted medical history. A 20-year-old man was initially diagnosed with precursor B lymphoblastic lymphoma and subsequently underwent allogeneic BMT. Nine months later, the patient was diagnosed with bronchiolitis obliterans with graft-versus-host disease, resulting in the development of BOS. Remarkably, 12 years after BMT, the patient was registered for lung transplantation. However, one year after registration, the patient developed a left pneumothorax. Despite rigorous efforts, including continuous thoracic drainage and autologous pleurodesis, the pneumothorax did not respond to treatment and required video-assisted thoracic surgery (VATS) bullectomy. The preoperative assessment revealed a challenging clinical finding characterized by the need for home oxygen therapy (5 L/min with a nasal cannula), severe Hugh-Jones classification IV-V, and marked hypercapnia (partial pressure of carbon dioxide (pCO2), 76 mmHg). Imaging studies, including high-resolution computed tomography and chest radiography, revealed hyperinflation, emphysematous changes, and bronchiectasis across all lung lobes, further complicating the patient's condition. Intraoperative management had the unique challenges of persistent hypoxia (P/F ratio 65-80), positive end-expiratory pressure of 5 cmH2O, and low tidal volumes (1.6-2.0 mL/kg) during one-lung ventilation. To address these problems, both-lung ventilation had to be performed intermittently. However, hyperventilation remained unmanageable, with maximum pCO2 values reaching 140 mmHg. Following surgery, the patient had to be admitted to the intensive care unit in an intubated state. Fortunately, the following day, the patient's condition improved markedly, his state of consciousness was clear (Glasgow Coma Scale 15) and his pCO2 level improved (66 mmHg) with spontaneous breath. This course of events allowed extubation and the patient was discharged to the general ward only two days after surgery. This case highlights the critical importance of a comprehensive preoperative assessment, including advanced imaging, when managing patients with BOS and complex pulmonary complications. Furthermore, it highlights the complexity and difficulty of perioperative respiratory management in such cases.

    DOI： 10.7759/cureus.46633

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  • A suicide attempt by intramuscular injection of pentobarbital sodium into rectus abdominis suggested by computed tomography. International journal

    Ryuichi Nakayama, Hiroki Sato, Naoya Yama, Keishi Ogura, Ryoko Kyan, Tomoki Hanazawa, Tomohiro Yoshizawa, Masamune Miyamoto, Yoshito Kamijo, Hirotoshi Mizuno, Hirotoshi Inamura, Keisuke Harada, Shuji Uemura, Eichi Narimatsu

    Forensic science, medicine, and pathology   19 ( 2 )   198 - 201   2023.6

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    Suicide attempts in humans due to injections of the veterinary drug pentobarbital sodium have been rarely reported. Herein, we present a case of a suicide attempt by intramuscular injection of pentobarbital sodium into the rectus abdominis muscle, which was suggested by computed tomography (CT). A 73-year-old man was brought to the emergency department with GCS 3 (E1V1M1) and an incised wound on the right side of the neck. A bottle of Somnopentyl® (pentobarbital sodium, 64.8 mg/ml), a 20-ml empty syringe with an 18-mm needle, and no. 10 scalpel were present at the scene. At the emergency department, the patient was intubated and was admitted to the intensive care unit. A urine drug screen test by SIGNIFY® ER was positive for benzodiazepines and barbiturates, and continuous veno-venous hemofiltration (CHF) was initiated. The route of drug administration was initially unknown; however, a CT scan revealed swelling of the left rectus abdominis muscle with a wound suggestive of a needle puncture, and the CT analysis suggested 38.16 ml as the maximum dose of pentobarbital sodium. On day 3, the patient's consciousness improved, and he was weaned off CHF and mechanical ventilation. There have been several reports of postmortem CT yielding information on the site of administration of intoxicants, but there have been none for surviving intoxicated patients. This is the first report of the usefulness of CT to identify the site of administration of the causative agent of intoxication while the patient is still alive.

    DOI： 10.1007/s12024-022-00508-y

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  • Correlation between the hysteresis of the pressure-volume curve and the recruitment-to-inflation ratio in patients with coronavirus disease 2019. International journal

    Ryuichi Nakayama, Naofumi Bunya, Shinshu Katayama, Yuya Goto, Yusuke Iwamoto, Kenshiro Wada, Keishi Ogura, Naoya Yama, Shintaro Takatsuka, Masumi Kishimoto, Kanako Takahashi, Ryuichiro Kakizaki, Keigo Sawamoto, Shuji Uemura, Keisuke Harada, Eichi Narimatsu

    Annals of intensive care   12 ( 1 )   106 - 106   2022.11

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    BACKGROUND: Since the response to lung recruitment varies greatly among patients receiving mechanical ventilation, lung recruitability should be assessed before recruitment maneuvers. The pressure-volume curve (PV curve) and recruitment-to-inflation ratio (R/I ratio) can be used bedside for evaluating lung recruitability and individualing positive end-expiratory pressure (PEEP). Lung tissue recruitment on computed tomography has been correlated with normalized maximal distance (NMD) of the quasi-static PV curve. NMD is the maximal distance between the inspiratory and expiratory limb of the PV curve normalized to the maximal volume. However, the relationship between the different parameters of hysteresis of the quasi-static PV curve and R/I ratio for recruitability is unknown. METHODS: We analyzed the data of 33 patients with severe coronavirus disease 2019 (COVID-19) who received invasive mechanical ventilation. Respiratory waveform data were collected from the ventilator using proprietary acquisition software. We examined the relationship of the R/I ratio, quasi-static PV curve items such as NMD, and respiratory system compliance (Crs). RESULTS: The median R/I ratio was 0.90 [interquartile range (IQR), 0.70-1.15] and median NMD was 41.0 [IQR, 37.1-44.1]. The NMD correlated significantly with the R/I ratio (rho = 0.74, P < 0.001). Sub-analysis showed that the NMD and R/I ratio did not correlate with Crs at lower PEEP (- 0.057, P = 0.75; and rho = 0.15, P = 0.41, respectively). On the contrary, the ratio of Crs at higher PEEP to Crs at lower PEEP (Crs ratio (higher/lower)) moderately correlated with NMD and R/I ratio (rho = 0.64, P < 0.001; and rho = 0.67, P < 0.001, respectively). CONCLUSIONS: NMD of the quasi-static PV curve and R/I ratio for recruitability assessment are highly correlated. In addition, NMD and R/I ratio correlated with the Crs ratio (higher/lower). Therefore, NMD and R/I ratio could be potential indicators of recruitability that can be performed at the bedside.

    DOI： 10.1186/s13613-022-01081-x

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  • Pulmonary torsion due to omentopexy after replacement of the descending aorta and esophagectomy. International journal

    Masayuki Akatsuka, Naoya Yama, Yutaka Iba, Yoshiki Masuda

    Oxford medical case reports   2022 ( 11 )   omac122   2022.11

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    DOI： 10.1093/omcr/omac122

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  • Deep learning algorithm to detect fibrosing interstitial lung disease on chest radiographs. International journal

    Hirotaka Nishikiori, Koji Kuronuma, Kenichi Hirota, Naoya Yama, Tomohiro Suzuki, Maki Onodera, Koichi Onodera, Kimiyuki Ikeda, Yuki Mori, Yuichiro Asai, Yuzo Takagi, Seiwa Honda, Hirofumi Ohnishi, Masamitsu Hatakenaka, Hiroki Takahashi, Hirofumi Chiba

    The European respiratory journal   61 ( 2 )   2022.10

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    BACKGROUND: Antifibrotic therapies are available to treat chronic fibrosing interstitial lung diseases (CF-ILDs), including idiopathic pulmonary fibrosis. Early use of these treatments is recommended to slow deterioration of respiratory function and to prevent acute exacerbation. However, identifying patients in the early stages of CF-ILD using chest radiographs (CRs) is challenging. In this study, we developed and tested a deep learning algorithm to detect CF-ILD using CR images. METHOD: From the image archive of Sapporo Medical University Hospital, 653 CRs from 263 patients with CF-ILDs and 506 from 506 patients without CF-ILD were identified; 921 were used for deep learning and 238 were used for algorithm testing. The algorithm was designed to output a numerical score ranging from 0 to 1, representing the probability of CF-ILD. Using the testing dataset, the algorithm's capability to identify CF-ILD was compared with that of doctors. A second dataset, in which CF-ILD was confirmed using computed tomography images, was used to further evaluate the algorithm's performance. RESULTS: The area under the curve of the receiver operating characteristic curve, which indicates the algorithm's detection capability, was 0.979. Using a score cutoff of 0.267, the sensitivity and specificity of detection were 0.896 and 1.000, respectively. These data showed that the algorithm's performance was non-inferior to that of doctors, including pulmonologists and radiologists; performance was verified using the second dataset. CONCLUSIONS: We developed a deep learning algorithm to detect CF-ILDs using CR images. The algorithm's detection capability was non-inferior to that of doctors.

    DOI： 10.1183/13993003.02269-2021

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  • Diagnosis of prosthetic joint infection at the hip using the standard uptake value of three-phase 99mTc-hydroxymethylene diphosphonate SPECT/CT.

    Naoya Yama, Satoshi Nagoya, Shintaro Sugita, Masayuki Koyama, Masamitsu Hatakenaka

    Annals of nuclear medicine   36 ( 7 )   634 - 642   2022.4

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    DOI： 10.1007/s12149-022-01745-5

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  • Abnormal [18F]fluorodeoxyglucose accumulation to tori tubarius in IgG4-related disease.

    Ken Nagahata, Masatoshi Kanda, Ryuta Kamekura, Masanari Sugawara, Naoya Yama, Chisako Suzuki, Kenichi Takano, Masamitsu Hatakenaka, Hiroki Takahashi

    Annals of nuclear medicine   36 ( 2 )   200 - 207   2022.2

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    OBJECTIVES: Tubarial glands (TGs) are recently refocused gland tissues localized near the tori tubarius in the nasopharynx and their clinical relevance is not clear yet. IgG4-related disease (IgG4-RD) is a progressive fibrosing condition and salivary glands are well-affected lesions. The aim of the present study is to examine [18F]fluorodeoxyglucose ([18F]FDG) accumulation to the tori tubarius in IgG4-related disease (IgG4-RD). METHODS: 48 patients with IgG4-RD who underwent positron emission tomography (PET) scanning with [18F]FDG were included and semi-quantitative analysis of [18F]FDG accumulation to tori tubarius was performed along with the clinical features and histopathological analysis. RESULTS: Of the 48 patients, abnormal [18F]FDG accumulation (metabolic tumour volume ≥ 1) to tori tubarius was observed in 15 (31.3%), all of whom had lesions in other head and neck glands. IgG4-RD patients with abnormal [18F]FDG accumulation to tori tubarius showed swollen nasopharyngeal walls around tori tubarius and forceps biopsy of the lesion revealed acinar cells and IgG4-positive plasma cells histologically. Abnormal [18F]FDG accumulation (maximum standard uptake value, metabolic tumour volume and total lesion glycolysis) to tori tubarius correlated with higher IgG4 and lower IgA serum concentrations. CONCLUSIONS: Abnormal [18F]FDG accumulation to tori tubarius can be observed in patients with IgG4-RD and the abnormal [18F]FDG accumulation to tori tubarius can be a clue of TG involvement in IgG4-RD.

    DOI： 10.1007/s12149-021-01691-8

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  • Self-correction of a migrated power-injectable peripherally inserted central catheter following contrast-enhanced computed tomography. International journal

    Ryuichi Nakayama, Naofumi Bunya, Naoya Yama, Tatsuki Nonaka

    Clinical case reports   10 ( 2 )   e05385   2022.2

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    The use of power-injectable peripherally inserted central catheter (PIPICC) is a common practice, but displacement of these lines following injection of contrast media has been reported in 15.4% of cases. This report presents imaging evidence of displacement and self-correction of a PIPICC line following contrast-enhanced computed tomography.

    DOI： 10.1002/ccr3.5385

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  • Pneumomediastinum as patient self-inflicted lung injury in patients with acute respiratory distress syndrome due to COVID-19: a case series. International journal

    Rika Watanabe, Ryuichi Nakayama, Naofumi Bunya, Naoya Yama, Yusuke Iwamoto, Yoichi Katayama, Takehiko Kasai, Keigo Sawamoto, Shuji Uemura, Eichi Narimatsu

    Acute medicine & surgery   9 ( 1 )   e796   2022

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    BACKGROUND: In patients with coronavirus disease (COVID-19) due to severe acute respiratory syndrome coronavirus 2 infection, pneumomediastinum has been increasingly reported in cases of noninvasive oxygen therapy, including high-flow nasal cannula, and invasive mechanical ventilation. However, its pathogenesis is still not understood. CASE PRESENTATION: We report two cases of pneumomediastinum in acute respiratory distress syndrome (ARDS) caused by COVID-19. In both cases, control of spontaneous breathing with neuromuscular blocking agents resulted in resolution of pneumoperitoneum. CONCLUSION: The improvement of pneumomediastinum with control of spontaneous breathing suggested patient self-inflicted lung injury as a possible mechanism in this case series. In ARDS cases with pneumomediastinum, in addition to controlling plateau pressure with conventional lung protective ventilation, spontaneous breathing should be controlled if the patient's inspiratory effort is suspected to be strong.

    DOI： 10.1002/ams2.796

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  • Displacement of a peripherally inserted central catheter after injection of contrast media. International journal

    Masayuki Akatsuka, Hiroomi Tatsumi, Naoya Yama, Yoshiki Masuda

    BMJ case reports   14 ( 9 )   2021.9

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    DOI： 10.1136/bcr-2021-246068

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  • Therapeutic Evaluation of Computed Tomography Findings for Efficacy of Prone Ventilation in Acute Respiratory Distress Syndrome Patients with Abdominal Surgery. International journal

    Masayuki Akatsuka, Hiroomi Tatsumi, Naoya Yama, Yoshiki Masuda

    Journal of critical care medicine (Universitatea de Medicina si Farmacie din Targu-Mures)   6 ( 1 )   32 - 40   2020.1

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    INTRODUCTION: In Acute Respiratory Distress Syndrome (ARDS), the heterogeneity of lung lesions results in a mis-match between ventilation and perfusion, leading to the development of hypoxia. The study aimed to examine the association between computed tomographic (CT scan) lung findings in patients with ARDS after abdominal surgery and improved hypoxia and mortality after prone ventilation. MATERIAL AND METHODS: A single site, retrospective observational study was performed at the Sapporo Medical University School of Medicine, Sapporo, Hokkaido, Japan, between 1st January 2004 and 31st October 2018. Patients were allocated to one of two groups after CT scanning according to the presence of ground-glass opacity (GGO) or alveolar shadow with predominantly dorsal lung atelectasis (DLA) on lung CT scan images. Also, Patients were divided into a prone ventilation group and a supine ventilation group when the treatment for ARDS was started. RESULTS: We analyzed data for fifty-one patients with ARDS following abdominal surgery. CT scans confirmed GGO in five patients in the Group A and in nine patients in the Group B, and DLA in 17 patients in the Group A and nine patients in the Group B. Both GGO and DLA were present in two patients in the Group A and nine patients in the Group B. Prone ventilation significantly improved patients' impaired ratio of arterial partial pressure of oxygen to fraction of inspired oxygen from 12 h after prone positioning compared with that in the supine position. Weaning from mechanical ventilation occurred significantly earlier in the Group A with DLA vs the Group B with DLA (P < 0.001). Twenty-eight-day mortality was significantly lower for the Group A with DLA vs the Group B with DLA (P = 0.035). CONCLUSIONS: These results suggest that prone ventilation could be effective for treating patients with ARDS as showing the DLA.

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  • 心臓交感神経イメージにおいて集積低下例ほど心臓リハビリテーションの治療効果が期待できる

    中田 潤, 藤戸 健史, 大堀 克彦, 山 直也, 矢野 俊之, 橋本 暁佳, 石合 純夫, 片野 唆敏, 本間 傑, 下村 佳奈子, 蝶野 大樹, 片寄 正樹

    日本心臓核医学会ニュースレター   21 ( 2 )   120 - 120   2019.6

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  • Repeatability analysis of ADC histogram metrics of the uterus. International journal

    Koichi Onodera, Masamitsu Hatakenaka, Naoya Yama, Maki Onodera, Tsuyoshi Saito, Thomas Christian Kwee, Taro Takahara

    Acta radiologica (Stockholm, Sweden : 1987)   60 ( 4 )   526 - 534   2019.4

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    BACKGROUND: Recently, histogram analysis based on voxel-wise apparent diffusion coefficient (ADC) value distribution has been increasingly performed. However, few studies have been reported regarding its repeatability. PURPOSE: To evaluate the repeatability of ADC histogram metrics of the uterus in clinical magnetic resonance imaging (MRI). MATERIAL AND METHODS: Thirty-three female patients who underwent pelvic MRI including diffusion-weighted imaging (DWI) were prospectively included after providing informed consent. Two sequential DWI acquisitions with identical parameters and position were obtained. Regions of interest (ROIs) for histologically confirmed uterine lesions (five cervical and three endometrial cancers, and one endometrial hyperplasia) and normal appearing tissues (21 endometrium and 33 myometrium) were assigned on the first DWI dataset and then pasted onto the second DWI dataset. ADC histogram metrics within the ROIs were calculated and repeatability was evaluated by calculating within-subject coefficient of variance (%) (wCV (%)) and Bland-Altman plot (%). RESULTS: ADC 10%, 25%, median, 75%, 90%, maximum, mean, and entropy showed high repeatability (wCV (%) < 7, 95% limit of agreement in Bland-Altman plot (%) < ±20), followed by ADC minimum (wCV (%) = 8.12, 95% limit of agreement in Bland-Altman plot (%) < ±30). However, ADC skewness and kurtosis showed very low repeatability in all evaluations. CONCLUSION: ADC histogram metrics like ADC 10%, 25%, median, 75%, 90%, maximum, mean, and entropy are robust biomarkers and could be applicable to clinical use. However, ADC skewness and kurtosis lack robustness. Radiologists should keep these characteristics and limitations in mind when interpreting quantitative DWI.

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  • [Impact of Misregistration between the Myocardial Perfusion Images and CT Attenuation Correction Map on the %up Take with 17 Segments Polar Map].

    Kenta Yoshikawa, Taiki Chono, Osamu Asanuma, Naoya Yama

    Nihon Hoshasen Gijutsu Gakkai zasshi   75 ( 9 )   892 - 899   2019

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    PURPOSE: Computed tomography (CT) attenuation correction of myocardial perfusion in single-photon emission computed tomography (SPECT) /CT systems is possibility of misregistration between emission and transmission scans. This study aimed to evaluate the influence of misregistration using a polar map of 17 segments model. METHODS: Using the fusion software, we assessed the magnitude and direction of misregistration in 200 consecutive myocardial perfusion SPECT images with 99mTechnetium (99mTc) tetrofosmin. After registration, CT data was shifted by ±1, ±2, and ±3 pixels along the cephalad/caudal, dorsal/ventral, and left/right axes, respectively. The registered image was compared with the shifted image. RESULTS: Misregistration between the SPECT and CT images occurred by 1-2 pixels in 127 cases (63.5%) and by 2 or more pixels in four cases (2%); the maximum misregistration was 1.2±0.4 pixels on average. The polar map scoring was most significantly affected by 3 pixel ventral shift. A ventral shift of 1 pixel affected the scores for the anterolateral and inferolateral segments, whereas a caudal shift of 1 pixel affected the scores for the anterior segment. CONCLUSION: Since the 17 segments model can evaluate the position more precisely than the five segments model, it is possible to evaluate up to 1 pixel misregistration.

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  • Traumatic Basilar Artery Entrapment without Longitudinal Clivus Fracture: A Case Report and Review of the Literature.

    Ayumu Yamaoka, Kei Miyata, Naofumi Bunya, Hirotoshi Mizuno, Hideto Irifune, Naoya Yama, Yukinori Akiyama, Takeshi Mikami, Masahiko Wanibuchi, Nobuhiro Mikuni

    Neurologia medico-chirurgica   58 ( 8 )   362 - 367   2018.8

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    In blunt cerebrovascular injury, reported traumatic basilar artery occlusions have involved dissection of the basilar artery, distal embolization due to traumatic vertebral artery dissection, or entrapment of the basilar artery into the clivus fracture. To date, however, there are no reports of traumatic basilar artery entrapment without a clivus fracture. Here, we report the first case of traumatic basilar artery occlusion caused by entrapment into an originally existing bone defect. A 67-year-old man with a history of treatment for intracranial aneurysm suffered multiple traumatic injuries in a fall. On arrival at our hospital, he presented with neurogenic shock with quadriplegia. Computed tomography (CT) showed small epidural hematoma, C4-6 cervical spinous process fracture, and Th2-3 vertebral body fracture. CT angiography revealed occlusion of the basilar artery trunk. As vertebrobasilar artery dissections and clivus fracture were not observed; however, we could not elucidate the pathology of the basilar artery occlusion. On day 4, after surgery for the cervical and thoracic lesions, he exhibited consciousness disturbance. Diffusion-weighted imaging on day 5 showed hyperintensities in the brainstem and cerebellum. Basi-parallel anatomic scanning magnetic resonance imaging showed that the basilar artery, while lacking vascular wall injuries, was tethered into the clivus. Antithrombotic therapy was performed, but the patient progressed to a locked-in state. Previous head CT before the trauma revealed a bone defect already present in the clivus. We speculated basilar artery entrapment into this preexisting bone defect. We must look for basilar artery injury in trauma patients even in the absence of clivus fracture.

    DOI： 10.2176/nmc.cr.2018-0041

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  • Clinical utility of 18F-fluorodeoxyglucose/positron emission tomography in diagnosis of immunoglobulin G4–related sclerosing sialadenitis Reviewed

    Kenichi Takano, Ryoto Yajima, Ryuta Kamekura, Motohisa Yamamoto, Hiroki Takahashi, Naoya Yama, Masamitsu Hatakenaka, Tetsuo Himi

    Laryngoscope   128 ( 5 )   1120 - 1125   2018.5

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    DOI： 10.1002/lary.26945

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  • The Japanese Clinical Practice Guidelines for Management of Sepsis and Septic Shock 2016 (J-SSCG 2016). International journal

    Osamu Nishida, Hiroshi Ogura, Moritoki Egi, Seitaro Fujishima, Yoshiro Hayashi, Toshiaki Iba, Hitoshi Imaizumi, Shigeaki Inoue, Yasuyuki Kakihana, Joji Kotani, Shigeki Kushimoto, Yoshiki Masuda, Naoyuki Matsuda, Asako Matsushima, Taka-Aki Nakada, Satoshi Nakagawa, Shin Nunomiya, Tomohito Sadahiro, Nobuaki Shime, Tomoaki Yatabe, Yoshitaka Hara, Kei Hayashida, Yutaka Kondo, Yuka Sumi, Hideto Yasuda, Kazuyoshi Aoyama, Takeo Azuhata, Kent Doi, Matsuyuki Doi, Naoyuki Fujimura, Ryota Fuke, Tatsuma Fukuda, Koji Goto, Ryuichi Hasegawa, Satoru Hashimoto, Junji Hatakeyama, Mineji Hayakawa, Toru Hifumi, Naoki Higashibeppu, Katsuki Hirai, Tomoya Hirose, Kentaro Ide, Yasuo Kaizuka, Tomomichi Kan'o, Tatsuya Kawasaki, Hiromitsu Kuroda, Akihisa Matsuda, Shotaro Matsumoto, Masaharu Nagae, Mutsuo Onodera, Tetsu Ohnuma, Kiyohiro Oshima, Nobuyuki Saito, So Sakamoto, Masaaki Sakuraya, Mikio Sasano, Norio Sato, Atsushi Sawamura, Kentaro Shimizu, Kunihiro Shirai, Tetsuhiro Takei, Muneyuki Takeuchi, Kohei Takimoto, Takumi Taniguchi, Hiroomi Tatsumi, Ryosuke Tsuruta, Naoya Yama, Kazuma Yamakawa, Chizuru Yamashita, Kazuto Yamashita, Takeshi Yoshida, Hiroshi Tanaka, Shigeto Oda

    Acute medicine & surgery   5 ( 1 )   3 - 89   2018.1

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    BACKGROUND AND PURPOSE: The Japanese Clinical Practice Guidelines for Management of Sepsis and Septic Shock 2016 (J-SSCG 2016), a Japanese-specific set of clinical practice guidelines for sepsis and septic shock created jointly by the Japanese Society of Intensive Care Medicine and the Japanese Association for Acute Medicine, was first released in February 2017 in Japanese. An English-language version of these guidelines was created based on the contents of the original Japanese-language version. METHODS: Members of the Japanese Society of Intensive Care Medicine and the Japanese Association for Acute Medicine were selected and organized into 19 committee members and 52 working group members. The guidelines were prepared in accordance with the Medical Information Network Distribution Service (Minds) creation procedures. The Academic Guidelines Promotion Team was organized to oversee and provide academic support to the respective activities allocated to each Guideline Creation Team. To improve quality assurance and workflow transparency, a mutual peer review system was established, and discussions within each team were open to the public. Public comments were collected once after the initial formulation of a clinical question (CQ), and twice during the review of the final draft. Recommendations were determined to have been adopted after obtaining support from a two-thirds (>66.6%) majority vote of each of the 19 committee members. RESULTS: A total of 87 CQs were selected among 19 clinical areas, including pediatric topics and several other important areas not covered in the first edition of the Japanese guidelines (J-SSCG 2012). The approval rate obtained through committee voting, in addition to ratings of the strengths of the recommendation and its supporting evidence were also added to each recommendation statement. We conducted meta-analyses for 29 CQs. Thirty seven CQs contained recommendations in the form of an expert consensus due to insufficient evidence. No recommendations were provided for 5 CQs. CONCLUSIONS: Based on the evidence gathered, we were able to formulate Japanese-specific clinical practice guidelines that are tailored to the Japanese context in a highly transparent manner. These guidelines can easily be used not only by specialists, but also by non-specialists, general clinicians, nurses, pharmacists, clinical engineers, and other healthcare professionals.

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  • The Japanese Clinical Practice Guidelines for Management of Sepsis and Septic Shock 2016 (J-SSCG 2016). International journal

    Osamu Nishida, Hiroshi Ogura, Moritoki Egi, Seitaro Fujishima, Yoshiro Hayashi, Toshiaki Iba, Hitoshi Imaizumi, Shigeaki Inoue, Yasuyuki Kakihana, Joji Kotani, Shigeki Kushimoto, Yoshiki Masuda, Naoyuki Matsuda, Asako Matsushima, Taka-Aki Nakada, Satoshi Nakagawa, Shin Nunomiya, Tomohito Sadahiro, Nobuaki Shime, Tomoaki Yatabe, Yoshitaka Hara, Kei Hayashida, Yutaka Kondo, Yuka Sumi, Hideto Yasuda, Kazuyoshi Aoyama, Takeo Azuhata, Kent Doi, Matsuyuki Doi, Naoyuki Fujimura, Ryota Fuke, Tatsuma Fukuda, Koji Goto, Ryuichi Hasegawa, Satoru Hashimoto, Junji Hatakeyama, Mineji Hayakawa, Toru Hifumi, Naoki Higashibeppu, Katsuki Hirai, Tomoya Hirose, Kentaro Ide, Yasuo Kaizuka, Tomomichi Kan'o, Tatsuya Kawasaki, Hiromitsu Kuroda, Akihisa Matsuda, Shotaro Matsumoto, Masaharu Nagae, Mutsuo Onodera, Tetsu Ohnuma, Kiyohiro Oshima, Nobuyuki Saito, So Sakamoto, Masaaki Sakuraya, Mikio Sasano, Norio Sato, Atsushi Sawamura, Kentaro Shimizu, Kunihiro Shirai, Tetsuhiro Takei, Muneyuki Takeuchi, Kohei Takimoto, Takumi Taniguchi, Hiroomi Tatsumi, Ryosuke Tsuruta, Naoya Yama, Kazuma Yamakawa, Chizuru Yamashita, Kazuto Yamashita, Takeshi Yoshida, Hiroshi Tanaka, Shigeto Oda

    Journal of intensive care   6   7 - 7   2018

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    BACKGROUND AND PURPOSE: The Japanese Clinical Practice Guidelines for Management of Sepsis and Septic Shock 2016 (J-SSCG 2016), a Japanese-specific set of clinical practice guidelines for sepsis and septic shock created jointly by the Japanese Society of Intensive Care Medicine and the Japanese Association for Acute Medicine, was first released in February 2017 and published in the Journal of JSICM, [2017; Volume 24 (supplement 2)] 10.3918/jsicm.24S0001 and Journal of Japanese Association for Acute Medicine [2017; Volume 28, (supplement 1)] http://onlinelibrary.wiley.com/doi/10.1002/jja2.2017.28.issue-S1/issuetoc.This abridged English edition of the J-SSCG 2016 was produced with permission from the Japanese Association of Acute Medicine and the Japanese Society for Intensive Care Medicine. METHODS: Members of the Japanese Society of Intensive Care Medicine and the Japanese Association for Acute Medicine were selected and organized into 19 committee members and 52 working group members. The guidelines were prepared in accordance with the Medical Information Network Distribution Service (Minds) creation procedures. The Academic Guidelines Promotion Team was organized to oversee and provide academic support to the respective activities allocated to each Guideline Creation Team. To improve quality assurance and workflow transparency, a mutual peer review system was established, and discussions within each team were open to the public. Public comments were collected once after the initial formulation of a clinical question (CQ) and twice during the review of the final draft. Recommendations were determined to have been adopted after obtaining support from a two-thirds (> 66.6%) majority vote of each of the 19 committee members. RESULTS: A total of 87 CQs were selected among 19 clinical areas, including pediatric topics and several other important areas not covered in the first edition of the Japanese guidelines (J-SSCG 2012). The approval rate obtained through committee voting, in addition to ratings of the strengths of the recommendation, and its supporting evidence were also added to each recommendation statement. We conducted meta-analyses for 29 CQs. Thirty-seven CQs contained recommendations in the form of an expert consensus due to insufficient evidence. No recommendations were provided for five CQs. CONCLUSIONS: Based on the evidence gathered, we were able to formulate Japanese-specific clinical practice guidelines that are tailored to the Japanese context in a highly transparent manner. These guidelines can easily be used not only by specialists, but also by non-specialists, general clinicians, nurses, pharmacists, clinical engineers, and other healthcare professionals.

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  • Three cases of implantation of a SureScan® system and MRI for investigating causes of pain.

    Kazunobu Takahashi, Atsushi Sawada, Soshi Iwasaki, Naoya Yama, Hiroyuki Takashima, Maki Onodera, Masamitsu Hatakenaka, Michiaki Yamakage

    Journal of anesthesia   31 ( 6 )   915 - 917   2017.12

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    We report three cases of implantation of the SureScan® system and magnetic resonance imaging (MRI) for investigating causes of pain. Although there were metal-induced artifacts on the MR images of 2 patients, the artifacts did not affect the images of structures that needed to be assessed to make the diagnosis. The SureScan® system enabled patients implanted with spinal cord stimulation devices to undergo MRI.

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  • Cerebral air embolism associated with penetrating lung injury: a case report and review of the literature. International journal

    Ayumu Yamaoka, Kei Miyata, Eichi Narimatsu, Eiji Sakawaki, Sonoko Sakawaki, Suguru Hirayama, Shuji Uemura, Naoya Yama

    Acute medicine & surgery   4 ( 2 )   213 - 216   2017.4

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    CASE: A 44-year-old man intentionally stabbed himself in the anterior neck and left thorax with a fruit knife. Physical examination revealed two open wounds entering the thoracic cavity in the front chest, and a stab wound entering the trachea at the neck. Two chest tubes were initially inserted for the left lung injury with open hemopneumothorax. Nevertheless, the worsening oxygenation required positive pressure ventilation (PPV) with endotracheal intubation. OUTCOME: Right hemiparesis was found during weaning from PPV. Magnetic resonance imaging revealed multiple infarctions in the area of the bifrontal and right temporal lobes. Cerebral air embolism (CAE) was strongly suspected from the imaging findings and clinical course. CONCLUSION: We concluded that mechanical ventilation was strongly involved in the occurrence of CAE. If delayed abnormal neurological findings are observed in patients with penetrating lung injuries receiving PPV management, CAE should be considered.

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  • Improvement in automated quantitation of myocardial perfusion abnormality by using iterative reconstruction image in combination with resolution recovery, attenuation and scatter corrections for the detection of coronary artery disease. Reviewed

    Chono T, Onoguchi M, Shibutani T, Hashimoto A, Nakata T, Yama N, Tsuchihashi K, Hatakenaka M

    Annals of nuclear medicine   31 ( 2 )   181 - 189   2017.2

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  • The signal intensity ratio of the optic nerve to ipsilateral frontal white matter is of value in the diagnosis of acute optic neuritis Reviewed

    Maki Onodera, Naoya Yama, Masato Hashimoto, Takaharu Shonai, Kazunori Aratani, Hiroyuki Takashima, Ken-ichi Kamo, Hiroshi Nagahama, Hiroshi Ohguro, Masamitsu Hatakenaka

    EUROPEAN RADIOLOGY   26 ( 8 )   2640 - 2645   2016.8

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    DOI： 10.1007/s00330-015-4114-4

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  • A percutaneous dilatational tracheotomy in a patient with brachiocephalic artery tortuous

    Kimijima Tomohiko, Masuda Yoshiki, Tatsumi Hiroomi, Goto Kyoko, Nawa Yuko, Yama Naoya, Yamakage Michiaki, Imaizumi Hitoshi

    Journal of the Japanese Society of Intensive Care Medicine   23 ( 2 )   179 - 180   2016

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    Language：Japanese   Publisher：The Japanese Society of Intensive Care Medicine  

    Other Link： http://search.jamas.or.jp/link/ui/2016251654

    DOI： 10.3918/jsicm.23.179

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  • An adolescent case of familial hyperparathyroidism with a germline frameshift mutation of the CDC73 gene.

    Takako Takeuchi, Yuko Yoto, Takeshi Tsugawa, Hotaka Kamasaki, Atsushi Kondo, Jiro Ogino, Tadashi Hasegawa, Naoya Yama, Sawa Anan, Shinya Uchino, Aki Ishikawa, Akihiro Sakurai, Hiroyuki Tsutsumi

    Clinical pediatric endocrinology : case reports and clinical investigations : official journal of the Japanese Society for Pediatric Endocrinology   24 ( 4 )   185 - 9   2015.10

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    A 13-yr-old boy who complained of persistent nausea, vomiting and weight loss had hypercalcemia and an elevated intact PTH level. Computed tomography confirmed two tumors in the thyroid gland. The tumors were surgically removed and pathologically confirmed as parathyroid adenoma. Because his maternal aunt and grandmother both had histories of parathyroid tumors, genetic investigation was undertaken for him, and a germline frameshift mutation of the CDC73 gene was identified. CDC73 gene analysis should be done on individuals who are at risk of familial hyperparathyroidism, including those who are asymptomatic, and they should be followed for potential primary hyperparathyroidism and associated disorders including resultant parathyroid carcinoma.

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  • Asialoglycoprotein receptor scintigraphy with Tc-99m-galactosyl human serum albumin (Tc-99m-GSA) as an early predictor of survival in acute liver failure Reviewed

    H. Tatsumi, Y. Masuda, H. Imaizumi, S. Yoshida, K. Goto, N. Yama, T. Mizuguchi, K. Hirata

    ANAESTHESIA AND INTENSIVE CARE   41 ( 4 )   523 - 528   2013.7

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  • 腎被膜原発平滑筋腫の1例

    北川 未央, 玉川 光春, 兵頭 秀樹, 兵頭 かずさ, 山 直也, 河合 有里子, 佐藤 大志, 荒谷 和紀, 小野寺 麻希, 笠原 理子, 鷲尾 嘉一, 斎藤 正人, 晴山 雅人, 舛森 直哉, 塚本 泰司

    Japanese Journal of Radiology   31 ( Suppl.I )   7 - 7   2013.2

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  • MRIによる前立腺癌の浸潤進展度の評価

    荒谷 和紀, 玉川 光春, 兵頭 秀樹, 兵頭 かずさ, 山 直也, 河合 有里子, 佐藤 大志, 小野寺 麻希, 笠原 理子, 鷲尾 嘉一, 斎藤 正人, 北川 未央, 晴山 雅人, 田中 俊明, 舛森 直哉, 塚本 泰司

    Japanese Journal of Radiology   31 ( Suppl.I )   7 - 7   2013.2

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  • 喉頭癌における軟骨浸潤に対する画像評価

    北川 未央, 玉川 光春, 兵頭 秀樹, 兵頭 かずさ, 山 直也, 河合 有里子, 佐藤 大志, 荒谷 和紀, 小野寺 麻希, 笠原 理子, 鷲尾 嘉一, 斎藤 正人, 浅井 真友美, 晴山 雅人, 氷見 徹夫

    Japanese Journal of Radiology   31 ( Suppl.I )   16 - 16   2013.2

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  • 脊髄障害を来したparaffinomaの1例

    小野寺 耕一, 荒谷 和紀, 玉川 光春, 兵頭 秀樹, 兵頭 かずさ, 山 直也, 河合 有里子, 佐藤 大志, 小野寺 麻希, 笠原 理子, 鷲尾 嘉一, 齋藤 正人, 浅井 真友美, 北川 未央, 晴山 雅人

    Japanese Journal of Radiology   31 ( Suppl.I )   16 - 16   2013.2

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  • A retrospective study on the transition of radiation dose rate and iodine distribution in patients with I-131-treated well-differentiated thyroid cancer to improve bed control shorten isolation periods Reviewed

    Naoya Yama, Koh-ichi Sakata, Hideki Hyodoh, Mitsuharu Tamakawa, Masato Hareyama

    ANNALS OF NUCLEAR MEDICINE   26 ( 5 )   390 - 396   2012.6

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  • 喉頭癌の軟骨浸潤の評価

    北川 未央, 玉川 光春, 兵頭 秀樹, 兵頭 かずさ, 山 直也, 佐藤 大志, 河合 友里子, 晴山 雅人, 畠中 正光, 長谷川 匡

    日本医学放射線学会学術集会抄録集   71回   S339 - S339   2012.2

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  • 札幌医科大学における法医Ai

    佐藤 大志, 兵頭 秀樹, 茅橋 正憲, 高田 優, 浅井 真友美, 鷲尾 嘉一, 笠原 理子, 荒谷 和紀, 河合 有里子, 山 直也, 兵頭 かずさ, 玉川 光春, 晴山 雅人, 松本 博志

    Japanese Journal of Radiology   30 ( Suppl.I )   10 - 10   2012.2

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  • Aiで同定された内因性くも膜下出血 病理解剖所見との対比

    北川 未央, 兵頭 秀樹, 佐藤 大志, 兵頭 かずさ, 山 直也, 河合 有里子, 荒谷 和紀, 笠原 理子, 鷲尾 嘉一, 浅井 真由美, 玉川 光春, 晴山 雅人, 成松 英智, 宮田 圭, 蕨 玲子

    日本医学放射線学会秋季臨床大会抄録集   46回   S510 - S510   2010.8

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  • 左SVCに還流した部分肺静脈還流異常の1例

    三浦 勝利, 兵頭 秀樹, 秋葉 英成, 玉川 光春, 兵頭 かずさ, 山 直也, 河合 有里子, 佐藤 大志, 小野寺 麻紀, 荒谷 和紀, 浅井 真友美, 晴山 雅人, 石田 禎夫, 安井 寛

    日独医報   54 ( 1 )   77 - 78   2009.2

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  • Assessment of Dural Arteriovenous Fistulas of the Cavernous Sinuses on 3D Dynamic MR Angiography Reviewed

    H. Akiba, M. Tamakawa, H. Hyodoh, K. Hyodoh, T. Nonaka, Y. Minamida, M. Hashimoto, M. Hareyama

    AMERICAN JOURNAL OF NEURORADIOLOGY   29 ( 9 )   1652 - 1657   2008.10

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  • Technetium Tc 99m methylene diphosphonate bone scintigraphy of rhabdomyolysis after near-drowning in cold seawater Reviewed

    Naoya Yama, Kazumitsu Koito, Kenji Fujimori, Masato Hareyama, Seiji Yoneta, Satoshi Nara, Yoshihiko Kurimoto, Eichi Narimatsu, Yasufumi Asai

    AMERICAN JOURNAL OF EMERGENCY MEDICINE   25 ( 7 )   848 - 850   2007.9

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  • Double-subtraction maximum intensity projection MR angiography for detecting the artery of Adamkiewicz and differentiating it from the drainage vein Reviewed

    Hideki Hyodoh, Ryuji Shirase, Hidenari Akiba, Mitsuharu Tamakawa, Kazusa Hyodoh, Naoya Yama, Takaharu Shonai, Masato Hareyama

    JOURNAL OF MAGNETIC RESONANCE IMAGING   26 ( 2 )   359 - 365   2007.8

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  • 【あなたのそばにもIPMN】こうみえるIPMN 放射線学的画像診断

    小井戸 一光, 廣川 直樹, 佐藤 大志, 斉藤 正人, 山 直也, 晴山 雅人, 西田 睦

    消化器内視鏡   19 ( 8 )   1081 - 1087   2007.8

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  • The value of multidetector row computed tomography in the diagnosis of traumatic clivus epidural hematoma in children: A three-year experience Reviewed

    Naoya Yama, Hitoshi Kano, Satoshi Nara, Yoshihiko Kurimoto, Eichi Narimatsu, Kazumitsu Koito, Yasufumi Asai, Masato Hareyama

    JOURNAL OF TRAUMA-INJURY INFECTION AND CRITICAL CARE   62 ( 4 )   898 - 901   2007.4

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    DOI： 10.1097/01.ta.0000221058.72995.c9

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  • Out-of-hospital cardiopulmonary arrest due to penetrating cardiac injury treated by percutaneous cardiopulmonary support in the emergency room: Report of a case Reviewed

    Yoshihiko Kurimoto, Hitoshi Kano, Naoya Yama, Satoshi Nara, Mamoru Hase, Yasufumi Asai

    SURGERY TODAY   37 ( 3 )   240 - 242   2007.3

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  • 【膵疾患の画像診断 最近のトレンド】膵疾患の超音波診断 最近の進歩

    小井戸 一光, 廣川 直樹, 堀 正和, 佐藤 大志, 宇佐見 陽子, 山 直也, 晴山 雅人, 西田 睦

    臨床画像   22 ( 12 )   1323 - 1333   2006.12

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  • Blind subxiphold pericardiotomy for cardiac tamponade because of acute hemopericardium Reviewed

    Yoshihiko Kurimoto, Mamoru Hase, Satoshi Nara, Naoya Yama, Nobuyoshi Kawaharada, Kiyofumi Morishita, Tetsuya Higami, Yasufumi Asai

    JOURNAL OF TRAUMA-INJURY INFECTION AND CRITICAL CARE   61 ( 3 )   582 - 585   2006.9

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  • Initial experiences in management of blunt aortic injury taking associated brain injury into consideration Reviewed

    Y Kurimoto, K Morishita, N Kawaharada, J Fukada, Y Hachiro, Y Fujisawa, T Saitoh, N Yama, M Hase, E Narimatsu, Y Asai

    CIRCULATION JOURNAL   70 ( 2 )   198 - 201   2006.2

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  • Nominal free air in the left inguinal fossa due to perforation of the sigmoid colon in a case of blunt abdominal trauma: CT diagnosis Reviewed

    N Yama, Y Kimura, H Tatsumi, C Kihara, Y Kurimoto, E Narimatsu, H Ura, K Koito, Y Asai, K Hirata, M Hreyama

    ABDOMINAL IMAGING   31 ( 1 )   57 - 58   2006.1

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  • Tumors of bone and soft tissue

    Mitsuharu Tamagawa, H. Akiba, H. Hyodoh, K. Hyodoh, N. Yama, Y. Kawaai, T. Sato, M. Hareyama

    Japanese Journal of Clinical Radiology   51 ( 2 )   255 - 267   2006

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  • Preliminary report of contrast-enhanced computed tomography for patients with a percutaneous cardiopulmonary support system Reviewed

    N Yama, Y Takeyama, K Tanno, S Nara, Y Itoh, K Mori, M Hase, Y Kurimoto, E Narimatsu, K Koito, Y Asai, M Hareyama

    JOURNAL OF COMPUTER ASSISTED TOMOGRAPHY   29 ( 6 )   760 - 764   2005.11

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    DOI： 10.1097/01.rct.0000181721.77221.84

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  • Tracheal bronchus mimicking bronchial intubation endoscopically: report of a case with airway burn Reviewed

    N Yama, K Koito, M Hareyama, S Nara, H Okamoto, Y Kurimoto, E Narimatsu, Y Asai

    AMERICAN JOURNAL OF EMERGENCY MEDICINE   23 ( 6 )   815 - 816   2005.10

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  • 経過観察中に膵管癌発見の契機となった超音波所見の検討

    西田 睦, 小井戸 一光, 廣川 直樹, 佐藤 大志, 河合 有里子, 染谷 正則, 庄内 孝春, 山 直也, 兵頭 秀樹, 晴山 雅人, 白石 祐子, 新山 智美, 木村 もと子, 今井 希一

    超音波医学   32 ( 5 )   479 - 479   2005.9

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  • Localization of intestinal bleeding using a fusion of Tc-99m-labeled RBC SPELT and X-ray CT Reviewed

    N Yama, E Ezoe, Y Kimura, M Mukaiya, K Fujimori, Y Kurimoto, K Koito, K Hirata, M Hareyama, Y Asai

    CLINICAL NUCLEAR MEDICINE   30 ( 7 )   488 - 489   2005.7

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  • A paratracheal cystic lesion in a patient with potential high-energy trauma Reviewed

    E Narimatsu, N Yama, W Danjoh, Y Kurimoto, Y Asai

    JOURNAL OF EMERGENCY MEDICINE   28 ( 3 )   333 - 335   2005.4

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    DOI： 10.1016/j.jemermed.2004.08.023

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  • Enhanced sonography using carbon dioxide gas for small hepatocellular carcinoma: A comparison study between pure carbon dioxide gas and carbon dioxide microbubbles Reviewed

    Kazumitsu Koito, Tsutomu Namieno, Naoki Hirokawa, Takeshi Ichimura, Mutsumi Nishida, Naoya Yama, Koichi Sakata, Masato Hareyama, Motoi Nishi

    Radiation Medicine - Medical Imaging and Radiation Oncology   23 ( 2 )   104 - 110   2005.3

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  • 造影エコーによるUAE治療効果判定

    佐藤 大志, 小井戸 一光, 廣川 直樹, 西田 睦, 山 直也, 染谷 正則, 兵頭 秀樹, 晴山 雅人

    超音波医学   32 ( 2 )   203 - 203   2005.3

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  • 肝・胆・膵領域におけるdifferential Tissue Harmonic Imagingの有用性の検討

    西田 睦, 小井戸 一光, 廣川 直樹, 佐藤 大志, 河合 有里子, 染谷 正則, 庄内 孝春, 中田 健生, 山 直也, 兵頭 秀樹, 晴山 雅人, 市村 健, 川岸 哲也

    超音波医学   32 ( 2 )   201 - 201   2005.3

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  • A case of anomalous subaortic left brachiocephalic vein mimicking mediastinal hematoma Reviewed

    N Yama, S Nara, Y Itoh, Y Kurimoto, E Narimatsu, Y Asai, K Koito, M Hareyama

    JOURNAL OF TRAUMA-INJURY INFECTION AND CRITICAL CARE   58 ( 2 )   419 - 420   2005.2

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    DOI： 10.1097/01.TA.0000142161.17648.FE

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  • Phase shift due to inversion recovery process and chemical shift effect in inversion recovery prepared gradient-echo magnetic resonance imaging Reviewed

    Naoya Yama, Miki Takeda, Mitsuharu Tamakawa, Hidenari Akiba, Kazumitsu Koito, Masato Hareyama

    Radiation Medicine - Medical Imaging and Radiation Oncology   23 ( 1 )   56 - 60   2005.2

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  • 頸部リンパ節良悪性鑑別のための新しい造影エコー法Micro Flow Imaging

    小井戸 一光, 西田 睦, 市村 健, 廣川 直樹, 河合 有里子, 染谷 正則, 庄内 孝春, 中田 健生, 山 直也, 兵頭 秀樹

    超音波医学   32 ( 1 )   32 - 32   2005.1

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  • 自己免疫性膵炎の治療効果と増悪の判定に造影超音波が有用であった一例

    小井戸 一光, 市村 健, 廣川 直樹, 西田 睦, 河合 有里子, 染谷 正則, 庄内 孝春, 中田 健生, 山 直也, 兵頭 秀樹

    超音波医学   32 ( 1 )   33 - 33   2005.1

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  • 造影超音波検査による進行膵管癌の治療効果判定 CD34抗体による免疫染色との対比検討

    西田 睦, 小井戸 一光, 市村 健, 廣川 直樹, 中田 健生, 染谷 正則, 庄内 孝春, 山 直也, 兵頭 秀樹, 晴山 雅人, 木村 幸子, 佐藤 昌昭, 大谷 静治

    超音波医学   32 ( 1 )   23 - 23   2005.1

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  • MDCTによる膵癌・胆管癌の進展度診断 切除例での検討

    市村 健, 小井戸 一光, 廣川 直樹, 西田 睦, 秋葉 英成, 玉川 光春, 兵頭 秀樹, 兵頭 かずさ, 武 美貴, 山 直也, 庄内 孝春, 佐藤 大志, 土本 正, 晴山 雅人, 平野 透

    日本医学放射線学会雑誌   64 ( 8 )   580 - 580   2004.11

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  • A simple but useful method of screening for mesenteric ischemia secondary to acute aortic dissection Reviewed

    Y Kurimoto, K Morishita, J Fukada, N Kawaharada, K Komatsu, N Yama, Y Asai, T Abe

    SURGERY   136 ( 1 )   42 - 46   2004.7

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    DOI： 10.1016/j.surg.2003.12.019

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  • 【単純・X線/CT これを見落としてはいけない】小腸 外傷性消化管穿孔

    山 直也, 浦 英樹, 佐藤 大志, 廣川 直樹, 西田 睦, 小井戸 一光, 晴山 雅人, 江副 英理, 鹿野 恒, 栗本 義彦, 成松 英智, 浅井 康文

    消化器の臨床   7 ( 3 )   246 - 248   2004.6

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  • Placement of arterial sheath for endovascular management in multiple trauma Reviewed

    N Yama, T Ichimura, N Hirokawa, K Koito, M Hareyama, Y Naito, S Sasaki, Y Yonemasu, Y Asai

    AMERICAN JOURNAL OF EMERGENCY MEDICINE   22 ( 3 )   245 - 246   2004.5

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  • 造影超音波による肝血流評価 造影超音波の後期相が診断に有用であった肝結節性病変の1例

    西田 睦, 小井戸 一光, 市村 健, 廣川 直樹, 堀 正和, 中田 健生, 山 直也, 庄内 孝春, 兵頭 秀樹, 晴山 雅人, 小関 至, 高木 秀安, 佐々木 茂, 今井 浩三, 池田 英之, 佐藤 昌明, 神代 正道

    北海道医学雑誌   79 ( 2 )   206 - 206   2004.4

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  • 肝腫瘤性血流の経時的変化 造影超音波にて興味ある造影効果を示した硬化型肝細胞癌の1例

    西田 睦, 小井戸 一光, 市村 健, 廣川 直樹, 佐藤 大志, 中田 健生, 山 直也, 庄内 孝春, 兵頭 秀樹, 玉川 光春, 晴山 雅人, 小関 至, 高木 秀安, 佐々木 茂, 今井 浩三, 木村 幸子, 佐藤 昌明

    北海道医学雑誌   79 ( 2 )   201 - 201   2004.4

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  • 造影超音波の後期相が診断に有用であった肝結節性病変の1例

    西田 睦, 小井戸 一光, 市村 健, 廣川 直樹, 中田 健生, 山 直也, 庄内 孝春

    超音波検査技術   29 ( 2 )   208 - 208   2004.4

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  • Pericardial hemorrhage secondary during computed tomography scanning for aortic dissecting aneurysm Reviewed

    N Yama, H Hyhodo, K Koito, M Hareyama, N Kawaharada, K Morishita, T Abe, Y Takeyama, Y Kurimoto, Y Itoh, Y Asai

    AMERICAN JOURNAL OF EMERGENCY MEDICINE   21 ( 6 )   512 - 513   2003.10

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  • Assessment of stent-grafting for aortic dissection using multislice computed tomography Reviewed

    Y Kurimoto, N Yama, K Morishita, Y Asai, T Abe

    ANNALS OF THORACIC SURGERY   76 ( 3 )   947 - 947   2003.9

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  • Thoracic involvement of type A aortic dissection and intramural hematoma: Diagnostic accuracy - Comparison of emergency helical CT and surgical findings Reviewed

    S Yoshida, H Akiba, M Tamakawa, N Yama, M Hareyama, K Morishita, T Abe

    RADIOLOGY   228 ( 2 )   430 - 435   2003.8

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  • 造影超音波による腎動静脈瘻・脾動脈瘤塞栓術の治療効果判定

    西田 睦, 市村 健, 廣川 直樹, 小井戸 一光, 中田 健生, 山 直也, 庄内 孝春, 兵頭 秀樹, 晴山 雅人, 奈良 和彦

    超音波医学   30 ( 4 )   J565 - J566   2003.7

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  • 退形成性膵管癌の1例

    小島 一男, 小井戸 一光, 市村 健, 廣川 直樹, 西田 睦, 中田 健生, 染谷 正則, 庄内 孝春, 山 直也, 兵頭 秀樹, 晴山 雅人, 木村 弘通, 山 光進

    超音波医学   30 ( 4 )   J571 - J571   2003.7

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  • ワークフロートコントロールシステムを用いた腹部造影超音波検査

    市村 健, 小井戸 一光, 廣川 直樹, 西田 睦, 中田 健生, 染谷 正則, 庄内 孝春, 山 直也, 兵頭 秀樹, 晴山 雅人, 佐野 明洋, 神山 直久, 小笠原 洋一

    超音波医学   30 ( 4 )   J566 - J567   2003.7

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  • Emergency endovascular stent-grafting for infected pseudoaneurysm of brachial artery Reviewed

    Y Kurimoto, Y Tsuchida, J Saito, N Yama, E Narimatsu, Y Asai

    INFECTION   31 ( 3 )   186 - 188   2003.6

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  • 造影超音波による進行性膵癌の治療効果判定

    西田 睦, 小井戸 一光, 市村 健, 廣川 直樹, 中田 健生, 染谷 正則, 庄内 孝春, 山 直也, 兵頭 秀樹, 大谷 静治, 木村 幸子, 佐藤 昌明

    膵臓   18 ( 3 )   436 - 436   2003.6

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  • 【内視鏡医のための膵画像診断】超音波検査・造影超音波検査による膵疾患の診断

    小井戸 一光, 市村 健, 廣川 直樹, 山 直也, 晴山 雅人, 西田 睦, 佐藤 武史, 神山 直久, 嶺 喜隆, 矢野 雅彦

    消化器内視鏡   15 ( 5 )   651 - 659   2003.5

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    膵疾患の画像診断においては超音波検査が第一選択である.距離分解能において超音波はEUS,IDUSに及ばないが,超音波検査もここ10数年の間に数々の開発が行われ,EUS,IDUSでは得られない情報が得られるようになった.Bモードにおいてはハーモニックイメージングにより膵内の小病変や膵管の軽度拡張が描出できるようになり,カラー/パワードプラで膵癌の脈管浸潤診断や血管性病変が診断可能となった.更に造影超音波の登場により,血流情報からのアプローチによって膵癌と腫瘤形成性膵炎の鑑別や,IPMTの微小乳頭状腫瘍の描出も可能となった.超音波は膵病変のスクリーニングにとどまらず,質的診断と病変のフォローに有用な検査法となったと言える

    Ichushi

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  • 造影超音波による進行膵癌の化学放射線療法前後の治療効果判定

    市村 健, 小井戸 一光, 廣川 直樹, 西田 睦, 中田 健生, 染谷 正則, 庄内 孝春, 山 直也, 兵頭 秀樹

    超音波医学   30 ( Suppl. )   S296 - S296   2003.4

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    Ichushi

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  • 造影超音波による原発性肝癌門脈腫瘍栓の治療効果判定

    西田 睦, 小井戸 一光, 市村 健, 廣川 直樹, 中田 健生, 染谷 正則, 庄内 孝春, 山 直也, 兵頭 秀樹

    超音波医学   30 ( Suppl. )   S361 - S361   2003.4

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  • 造影超音波によって嚢胞壁在結節が明瞭となった膵IPMTの1例

    宇佐見 陽子, 小井戸 一光, 荒谷 和紀, 小島 一男, 高木 克, 廣川 直樹, 市村 健, 中田 健生, 庄内 孝春, 山 直也, 兵頭 秀樹, 西田 睦

    超音波医学   30 ( 2 )   J237 - J237   2003.3

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  • 造影超音波検査による進行膵管癌の化学放射線療法の治療効果判定

    西田 睦, 小井戸 一光, 市村 健, 廣川 直樹, 中田 健生, 染谷 正則, 庄内 孝春, 山 直也, 兵頭 秀樹, 晴山 雅人

    超音波医学   30 ( 2 )   J238 - J238   2003.3

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  • 3D造影超音波検査(3D-EU)を用いた肝腫瘍の非手術的治療効果判定

    市村 健, 小井戸 一光, 廣川 直樹, 中田 健生, 染谷 正則, 庄内 孝春, 山 直也, 兵頭 秀樹, 西田 睦

    超音波医学   30 ( 2 )   J236 - J237   2003.3

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  • Efficacy of SPIO-MR imaging in the diagnosis of liver metastases from colorectal carcinomas Reviewed

    T Furuhata, K Okita, T Tsuruma, F Hata, Y Kimura, T Katsuramaki, M Mukaiya, N Hirokawa, T Ichimura, N Yama, K Koito, K Sasaki, K Hirata

    DIGESTIVE SURGERY   20 ( 4 )   321 - 325   2003

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    DOI： 10.1159/000071758

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  • 3-D超音波が癌の進展度診断に有用であった,胆嚢管癌と膵癌の2例

    土本 正, 小井戸 一光, 市村 健, 廣川 直樹, 染谷 正則, 庄内 孝春, 山 直也, 兵頭 秀樹, 河合 有里子, 晴山 雅人

    超音波医学   29 ( 4 )   J401 - J401   2002.7

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  • 造影超音波検査による肝腫瘍の鑑別診断 CT,CTAとの対比

    小井戸 一光, 市村 健, 廣川 直樹, 土本 正, 染谷 正則, 庄内 孝春, 山 直也, 兵頭 秀樹, 河合 有里子, 晴山 雅人

    超音波医学   29 ( 4 )   J400 - J400   2002.7

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  • Dynamic flowを用いた肝腫瘍に対する非手術的治療の効果判定

    市村 健, 小井戸 一光, 廣川 直樹, 河合 有里子, 中田 健生, 庄内 孝春, 染谷 正則, 山 直也, 兵頭 秀樹, 佐藤 武史

    超音波医学   29 ( Suppl. )   S375 - S375   2002.5

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  • Brachial plexus: Normal anatomy and pathological conditions Reviewed

    Kazusa Hyodoh, Hideki Hyodoh, Hidenari Akiba, Mitsuharu Tamakawa, Noriko Nakamura, Naoya Yama, Takaharu Syonai, Tadashi Tsuchimoto, Hidechika Ohmoto, Masashi Ogasawara, Michio Banda, Makoto Furuse, Masato Hareyama

    Current Problems in Diagnostic Radiology   31 ( 5 )   179 - 188   2002

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    DOI： 10.1067/mdr.2002.127636

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  • A case of hepatocellular carcinoma: The feasibility of intravenous contrast enhanced ultrasonography in evaluating percutaneous microwave coagulation therapy

    Naoki Hirokawa, Kazumitsu Koito, Sjsum, Kensei Nakata, Takeshi Ichimura, Masanori Someya, Takaharu Shounai, Naoya Yama, Hideki Hyoudou

    Journal of Medical Ultrasonics   29 ( 1 )   J17 - J21   2002

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  • Spiral CT venography of the lower extremities by injection via an arm vein in patients with leg swelling Reviewed

    S Yoshida, H Akiba, M Tamakawa, N Yama, M Takeda, M Hareyama

    BRITISH JOURNAL OF RADIOLOGY   74 ( 887 )   1013 - 1016   2001.11

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  • Virtual CT cholangioscopy: Comparison with fiberoptic cholangioscopy Reviewed

    K Koito, T Namieno, N Hirokawa, T Ichimura, T Syonai, N Yama, M Mukaiya, K Hirata, K Sakata, M Hareyama

    ENDOSCOPY   33 ( 8 )   676 - 681   2001.8

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  • Pancreas: imaging diagnosis with color/power Doppler ultrasonography, endoscopic ultrasonography, and intraductal ultrasonography Reviewed

    K Koito, T Namieno, T Nagakawa, N Hirokawa, T Ichimura, T Syonai, N Yama, M Someya, K Nakata, K Sakata, M Hareyama

    EUROPEAN JOURNAL OF RADIOLOGY   38 ( 2 )   94 - 104   2001.5

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  • The spectrum of findings in supra-aortic Takayasu's arteritis as seen on spiral CT angiography and digital subtraction angiography Reviewed

    S Yoshida, H Akiba, M Tamakawa, N Yama, M Takeda, M Hareyama, T Nakata, K Shimamoto

    CARDIOVASCULAR AND INTERVENTIONAL RADIOLOGY   24 ( 2 )   117 - 121   2001.3

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  • Usefulness of magnetic resonance imaging for surgical management of extravasation of an antitumor agent: a case report Reviewed

    N Yama, Y Tsuchida, S Nuka, S Kitagawa, J Saito, H Hyodoh, K Hyodoh, K Koito, M Tamakawa, H Akiba, M Hareyama, Y Asai

    JAPANESE JOURNAL OF CLINICAL ONCOLOGY   31 ( 3 )   122 - 124   2001.3

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  • CT arteriography-guided embolization in hepatic bleeding: A case report Reviewed

    N. Yama, S. Kitagawa, J. Saito, H. Inomata, K. Koito, M. Tamakawa, H. Akiba, M. Hareyama, Y. Asai

    Emergency Radiology   8 ( 1 )   55 - 58   2001

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    DOI： 10.1007/PL00011872

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  • Spontaneously reduced midgut malrotation: CT diagnosis Reviewed

    N Yama, H Akiba, M Tamakawa, A Oouchi, K Sakata, K Koito, M Hareyama, K Morita

    ABDOMINAL IMAGING   25 ( 2 )   132 - 133   2000.3

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  • Acquired anomalous intrapulmonary venous connection secondary to pulmonary venous stenosis Reviewed

    S Yoshida, H Akiba, M Tamakawa, M Takeda, N Yama, M Hareyama, N Takagi, S Kikuchi, T Abe

    BRITISH JOURNAL OF RADIOLOGY   73 ( 866 )   211 - 213   2000.2

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  • Anomalous vessels in the middle ear associated with congenital anomalies of the internal carotid artery Reviewed

    T Himi, H Akiba, N Yama, M Sakata, A Kataura

    ORL-JOURNAL FOR OTO-RHINO-LARYNGOLOGY AND ITS RELATED SPECIALTIES   61 ( 4 )   219 - 223   1999.7

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  • Pseudoaneurysm of the superficial femoral artery in Behcet's disease with spontaneous thrombosis followed by CT angiography Reviewed

    S Yoshida, H Akiba, M Tamakawa, M Takeda, N Yama, M Hareyama, K Morita, A Masuda, K Shimamoto

    CARDIOVASCULAR AND INTERVENTIONAL RADIOLOGY   21 ( 4 )   342 - 344   1998.7

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  • Mucin-producing pancreatic tumors: Comparison of MR cholangiopancreatography with endoscopic retrograde cholangiopancreatography Reviewed

    K Koito, T Namieno, T Ichimura, N Yama, M Hareyama, K Morita, M Nishi

    RADIOLOGY   208 ( 1 )   231 - 237   1998.7

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  • Long survival of patients with unresectable cervical carcinoma after radiotherapy Reviewed

    K Sakata, M Hareyama, N Yama, A Oouchi, M Shido, H Nagakura, K Morita, R Kudo

    JAPANESE JOURNAL OF CLINICAL ONCOLOGY   27 ( 4 )   285 - 287   1997.8

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MISC

  • Epithelioid Sarcomaの画像

    土屋 高旭, 玉川 光春, 河合 有里子, 荒谷 和紀, 兵藤 秀樹, 山 直也, 庄内 孝春, 佐藤 大志, 小野寺 麻希, 鷲尾 嘉一, 浅井 真友美, 畠中 正光

    Japanese Journal of Radiology   32 ( Suppl. )   3 - 3   2014.2

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    Ichushi

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  • Radiographic Examinations for Severe Sepsis/Septic Shock Patients

    36 ( 11 )   987 - 990   2012.11

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  • A case of Churg-Strauss syndrome complicated with diffuse alveolar hemorrhage that was treated by plasma exchange

    Yoshida Shin-ichiro, Tanabe Miyuki, Masuda Yoshiki, Imaizumi Hitoshi, Yama Naoya, Tatsumi Hiroomi, Goto Kyoko, Asai Yasufumi

    Journal of the Japanese Society of Intensive Care Medicine   19 ( 4 )   623 - 627   2012

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    We report a case of severe Churg-Strauss syndrome (CSS) complicated with diffuse alveolar hemorrhage. A 47-year-old female patient complicated with diffuse alveolar hemorrhage, disseminated intravascular coagulation and intracerebral hemorrhage was admitted to our ICU due to acute respiratory failure. As a result of several examinations, the patient was first diagnosed as having CSS. After treatment with high-dose steroid under mechanical ventilation, acute respiratory failure with diffuse alveolar hemorrhage was improved. However, when the steroid dose was reduced, diffuse alveolar hemorrhage recurred. Therefore, plasma exchange therapy was performed and resulted in dramatic improvement of recurrent diffuse alveolar hemorrhage, and the patient was weaned from mechanical ventilation and survived. Generally, immunosupressant agents are recommended for treatment of CSS when there is no response to steroid therapy. However, it has been demonstrated that the main cause of death in CSS patients with diffuse alveolar hemorrhage is sepsis. Therefore, plasma exchange rather than immunosuppressant therapy is a useful option for treatment of severe CSS to prevent complication with severe infection.

    DOI： 10.3918/jsicm.19.623

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  • Change of radioactivity of aqueous solution of I-131 with evaporation

    ( 7 )   34 - 36   2011.12

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  • Attenuation of the radiation dose rate in patients treated with I-131

    ( 6 )   34 - 36   2010.12

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  • Management of the radiation dose rate and iodine distribution in patients treated with I-131

    ( 5 )   29 - 31   2009.12

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  • False working of fire alarm due to radiation

    ( 4 )   37 - 39   2008.12

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  • Chest X-ray of aortic injury

    The Japanese journal of acute medicine   32 ( 13 )   1853 - 1856   2008.12

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  • Thoracic Aortic Stent Grafting as a Life-saving Procedure in an Emergency Medical Center

    KURIMOTO Yoshihiko, ASAI Yasufumi, HASE Mamoru, NARA Satoshi, MORI Kazuhisa, YAMA Naoya, ITO Toshiro, BABA Toshio, KAWAHARADA Nobuyoshi, HIGAMI Tetsuya

    48 ( 3 )   283 - 292   2008.6

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  • Enhanced ultrasonography findings of echinococcossis of the liver

    SAITOU Masato, HIROKAWA Naoki, SATOH Taishi, KAWAI Yuriko, KASAHARA Michiko, YAMA Naoya, HAREYAMA Masato, NISHIDA Mutsumi, KOITO Kazumitsu

    35   S452   2008.4

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  • Ultrasound of small pancreatic cancer : comparison with CT and endoscopic ultrasound

    HIROKAWA Naoki, SAITO Masato, KOITO Kazumitsu, SATOH Taishi, KAWAI Yuriko, KASAHARA Michiko, YAMA Naoya, HAREYAMA Masato

    35   S373   2008.4

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  • 巻頭インタビュー 北海道の地域医療に貢献する 札幌医科大学付属病院院長 塚本泰司先生 放射線医学講座 山直也先生に聞く

    塚本 泰司, 山 直也, 寺田

    PET journal   ( 4 )   4 - 6   2008

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  • Imaging of aortic aneurysm

    The Japanese journal of acute medicine   31 ( 4 )   387 - 391   2007.4

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  • A case of spinal epidural and pelvic abscess with the rectal perforation

    Hiroaki Shima, Eiri Ezoe, Osamu Nara, Koji Hashimoto, Reiko Kyan, Masato Isobe, Tomohisa Furuhata, Naoya Yama, Yasufumi Asai, Koichi Hirata

    Japanese Journal of Gastroenterological Surgery   40 ( 5 )   665 - 670   2007

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    DOI： 10.5833/jjgs.40.665

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  • A case of spinal epidural and pelvic abscess with the rectal perforation

    Hiroaki Shima, Eiri Ezoe, Osamu Nara, Koji Hashimoto, Reiko Kyan, Masato Isobe, Tomohisa Furuhata, Naoya Yama, Yasufumi Asai, Koichi Hirata

    Japanese Journal of Gastroenterological Surgery   40 ( 5 )   665 - 670   2007

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    DOI： 10.5833/jjgs.40.665

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  • Abdominal Emergency Medicine and Information System : Transporting a Patient by Image Transmission Using E-mail from a Remote Area and as Telemedicine Image Transmission Using Digital Cellular Phone from Ambulance

    EZOE Eiri, ITOH Yasushi, YAMA Naoya, SHIMA Hiroaki, HIRATA Koichi, ASAI Yasufumi

    26 ( 5 )   611 - 616   2006.7

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    DOI： 10.11231/jaem1993.26.611

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  • EVALUATION OF LIVER FUNCTION PROGNOSIS BY TC-99m-GSA LIVER SCINTIGRAPHY IN SEVERE LIVER DYSFUNCTION WITH LIVER TRAUMA

    ISOBE Masato, EZOE Eiri, YAMA Naoya, WADA Takeshi, KURIMOTO Yoshihiko, MASUDA Yoshiki, IMAIZUMI Hitoshi, ASAI Yasuhumi

    20 ( 3 )   272 - 277   2006.7

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  • A Novel Method for the Detection and the Localization of Intestinal Bleeding Using a Fusion Image of Tc-99m-labeled RBC SPECT and X-ray CT

    KIMURA Yasutoshi, YAMA Naoya, ISOBE Masato, NOBUOKA Takayuki, FURUHATA Tomohisa, ASAI Yasufumi, HAREYAMA Masato, HIRATA Koichi

    26 ( 3 )   387 - 389   2006.3

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    DOI： 10.11231/jaem1993.26.387

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  • Abdominal Emergency Medicine and Information System-Transporting a Patient by Image Transmission Using E-mail from a Remote Area and as Telemedicine Image Transmission Using Digital Cellular Phone from Ambulance-

    Ezoe Eiri, Itoh Yasushi, Yama Naoya, Shima Hiroaki, Hirata Koichi, Asai Yasufumi

    Nihon Fukubu Kyukyu Igakkai Zasshi (Journal of Abdominal Emergency Medicine)   26 ( 5 )   611 - 616   2006

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    It is important to link up with distant health communityies in emergency medicine. We decided to transport a patient with an epidural abscess from a remote area by image transmission using E-mail. E-mail is independent of time and area. We established mobile telemedicine via image transmission using digital cellular phone from an ambulance. This is useful for prediction of patient status.

    DOI： 10.11231/jaem1993.26.611

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  • A Novel Method for the Detection and the Localization of Intestinal Bleeding Using a Fusion Image of Tc-99m-labeled RBC SPECT and X-ray CT

    Kimura Yasutoshi, Yama Naoya, Isobe Masato, Nobuoka Takayuki, Furuhata Tomohisa, Asai Yasufumi, Hareyama Masato, Hirata Koichi

    Nihon Fukubu Kyukyu Igakkai Zasshi (Journal of Abdominal Emergency Medicine)   26 ( 3 )   387 - 389   2006

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    Although Tc-99m-labeled RBC SPECT is sensitive for detection of intestinal bleeding, it cannot provide a highdegree of specific anatomic information. We introduced a novel method which facilitates the detection and the localizationof intestinal bleeding using a fusion image of Tc-99m-Labeled RBC SPECT and X-ray CT. The fused image iscomposed of those from Tc-99m-labeled RBC SPECT and from x-ray CT and able to reveal small intestinal bleedingwith specific anatomic information. We believe that the fused image is useful for anatomic localization of gastrointestinalbleeding and helpful for surgical intervention.

    DOI： 10.11231/jaem1993.26.387

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  • Evaluation of the treatment effect of chemoradiation for advanced pancreatic cancer with enhanced ultrasonography

    SATOH Taishi, KOITO Kazumitsu, NISHIDA Mustumi, HIROKAWA Naoki, KAWAAI Yuriko, SOMEYA Masanori, SHOUNAI Takaharu, YAMA Naoya, HYOUDOU Hideki

    32 ( Suppl. )   S179 - S179   2005.4

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  • Diagnositic ability of Contrast Enhanced Ultrasound with DD-723 in liver tumors

    NISHIDA Mutsumi, KOITO Kazumitsu, HIROKAWA Naoki, SATOH Taishi, KAWAI Yuriko, SOMEYA Masanori, SHONAI Takaharu, YAMA Naoya, HYODOH Hideki, HAREYAMA Masato

    32 ( Suppl. )   S192 - S192   2005.4

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  • Evaluation of Local Tumor Control, Survival rate and Apoptosis of Rat Liver Cancer sonicated by High Intensity Focused Ultrasound

    HIROKAWA Naoki, KOITO Kazumitsu, NISHIDA Mutsumi, SATOH Taishi, KAWAI Yuriko, SOMEYA Masanori, SYONAI Takaharu, YAMA Naoya, HYODO Hideki, KUDO Nobuki, YAMAMOTO Katsuyuki, HAREYAMA Masato

    32 ( Suppl. )   S242 - S242   2005.4

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  • Evaluation of the treatment effect of chemoradiation for advanced pancreatic cancer with enhanced ultrasonography

    SATOH Taishi, KOITO Kazumitsu, NISHIDA Mustumi, HIROKAWA Naoki, KAWAAI Yuriko, SOMEYA Masanori, SHOUNAI Takaharu, YAMA Naoya, HYOUDOU Hideki

    32 ( Suppl. )   S179 - S179   2005.4

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  • Diagnositic ability of Contrast Enhanced Ultrasound with DD-723 in liver tumors

    NISHIDA Mutsumi, KOITO Kazumitsu, HIROKAWA Naoki, SATOH Taishi, KAWAI Yuriko, SOMEYA Masanori, SHONAI Takaharu, YAMA Naoya, HYODOH Hideki, HAREYAMA Masato

    32 ( Suppl. )   S192 - S192   2005.4

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  • Evaluation of Local Tumor Control, Survival rate and Apoptosis of Rat Liver Cancer sonicated by High Intensity Focused Ultrasound

    HIROKAWA Naoki, KOITO Kazumitsu, NISHIDA Mutsumi, SATOH Taishi, KAWAI Yuriko, SOMEYA Masanori, SYONAI Takaharu, YAMA Naoya, HYODO Hideki, KUDO Nobuki, YAMAMOTO Katsuyuki, HAREYAMA Masato

    32 ( Suppl. )   S242 - S242   2005.4

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  • New Approach to Detecting Cervical Lymph Node Metastasis Using Contrast-Enhanced Ultrasound : Micro Flow Imaging with Levovist^【○!R】

    NISHIDA Mutsumi, KOITO Kazumitsu, ICHIMURA Takeshi, HIROKAWA Naoki, KAWAI Yuriko, SOMEYA Masanori, SYONAI Takaharu, NAKATA Kensei, YAMA Naoya, KAMIYAMA Naohisa

    31 ( 5 )   J347 - J353   2004.9

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  • New approach to the detection of Cervical Lymph Node metastasis by contrast enhanced Ultrasound : Micro Flow Imaging applied for Levovist

    NISHIDA Mutsumi, KOITO Kazumitsu, ICHIMURA Takeshi, HIROKAWA Naoki, KAWAI Yuriko, SOMEYA Masanori, SYONAI Takaharu, NAKATA Kensei, YAMA Naoya, HYOUDOU Hideki, HAREYAMA Naoto, NAKAYA Shigemitsu, KAMIYAMA Naoihsa

    31 ( Suppl. )   S96 - S96   2004.4

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    Ichushi

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  • Value of fast dynamic contrast-enhanced MRI with endorectal coil in patients with elevated PSA levels after radical prostatectomy

    M Takeda, M Tamakawa, H Akiba, M Hareyama, H Hyodo, K Hyodo, N Yama, T Shonai

    AMERICAN JOURNAL OF ROENTGENOLOGY   182 ( 4 )   118 - 118   2004

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  • 胸部X線,胸部CT,MRI,心臓核医学検査 (特集 胸部外傷--診断・治療の進歩) -- (各種診断法の有用性と限界)

    山 直也, 晴山 雅人, 浅井 康文

    救急医学   26 ( 12 )   1684 - 1691   2002.11

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  • A Case of Hepatocellular Carcinoma : The Feasibility of Intravenous Contrast Enhanced Ultrasonography in Evaluating Percutaneous Microwave Coagulation Therapy

    HIROKAWA Naoki, KOITO Kazumitsu, NAKATA Kensei, ICHIMURA Takeshi, SOMEYA Masanori, SHOUNAI Takaharu, YAMA Naoya, HYOUDOU Hideki

    29 ( 1 )   J17 - J21   2002.1

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  • Segmental analysis of cochlea on three-dimensional MR imaging and high-resolution CT

    H Akiba, M Tamakawa, H Hyodoh, K Hyodoh, N Nakamura, N Yama

    RADIOLOGY   221   135 - 135   2001.11

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  • Feasibility evaluation of new Tc-99m-GSA index to estimate liver function with a short-term acquisition

    K Fujimori, N Yama, M Takeda, M Hareyama

    EUROPEAN JOURNAL OF NUCLEAR MEDICINE   28 ( 8 )   1087 - 1087   2001.8

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  • Tc-99m-galactosyl human serum albumin (Tc-99m-GSA) early-phase index - Is it possible to estimate liver function with a short-term acquisition?

    K Fujimori, T Satoh, N Yama, M Hareyama

    JOURNAL OF NUCLEAR MEDICINE   42 ( 5 )   328P - 328P   2001.5

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  • Early brain CAT findings are useful to predict neurological outcome after cardiac arrest

    Y Takeyama, K Mori, Y Itoh, S Nara, M Yoshida, Y Asai, N Yama

    CRITICAL CARE MEDICINE   28 ( 12 )   A166 - A166   2000.12

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  • Multi-sectional fast dynamic contrast-enhanced MR imaging of head and neck malignant neoplasms

    H Akiba, M Tamakawa, S Yoshida, M Takeda, N Yama, M Hareyama

    RADIOLOGY   217   177 - 178   2000.11

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  • Segmental decreased uptake of Tc-99m-labeled galactosyl-neoglycoalbumin in nontumorous liver tissue: Sensitivity analysis of the factors influencing liver uptake with non-linear compartment model.

    K Fujimori, K Ichimura, N Hirokawa, N Yama, S Yoshida, M Takeda, T Shounai, K Koito, M Hareyama

    JOURNAL OF NUCLEAR MEDICINE   41 ( 5 )   319P - 319P   2000.5

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  • Mucin-producing pancreatic tumors: comparison of MR cholangiopancreatography with endoscopic retrograde cholangiopancreatography

    K Koito, T Namieno, T Ichimura, N Yama, M Hareyama, K Morita, M Nishi

    GASTROINTESTINAL ENDOSCOPY   50 ( 4 )   591 - 592   1999.10

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  • Estimation of ^<99m>Tc-GSA Receptor Amount by Non-Linear 3-Compartment Model : Ligand-Receptor Binding Model without Blood Sampling

    FUJIMORI Kenji, SHOUNAI Takaharu, KOITO Kazumitsu, YOSHIDA Satoru, TAKEDA Miki, YAMA Naoya, KATSURAMAKI Tadashi, FURUHATA Tomohisa, HIRATA Kouichi, HAREYAMA Masato

    KAKU IGAKU (Jpn J Nucl Med)   36 ( 7 )   753 - 760   1999.9

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  • Comparison between High and Low Dose Rate of Intracavitary Irradiation for Carcinoma of The Uterine Cervix

    HAREYAMA Masato, OOUCHI Atusi, SIDOU Mituo, TAKEDA Miki, YAMA Naoya, SAKATA Kouichi, MORITA Kazuo

    17 ( 1 )   143 - 143   1995.10

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Research Projects

  • Detection of imaging features related to node metastasis in uterine endometrial cancer

    Grant number：23K07209  2023.4 - 2026.3

    Japan Society for the Promotion of Science  Grants-in-Aid for Scientific Research  Grant-in-Aid for Scientific Research (C)

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    Grant amount：\4680000 （ Direct Cost: \3600000 、 Indirect Cost：\1080000 ）

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  • Evaluation of rectal cancer aggressiveness based on conductivity imaging

    Grant number：18K07635  2018.4 - 2023.3

    Japan Society for the Promotion of Science  Grants-in-Aid for Scientific Research  Grant-in-Aid for Scientific Research (C)

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    Grant amount：\4290000 （ Direct Cost: \3300000 、 Indirect Cost：\990000 ）

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  • Establishment of early detection and treatment assessment of pulmonary hypertension by PC-cine MRI

    Grant number：16K10323  2016.4 - 2019.3

    Japan Society for the Promotion of Science  Grants-in-Aid for Scientific Research  Grant-in-Aid for Scientific Research (C)

    Murayamma Sadayuki

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    Grant amount：\4550000 （ Direct Cost: \3500000 、 Indirect Cost：\1050000 ）

    Phase contrast MRI (PC-MRI) can determine pulmonary hemodynamics noninvasively. Pulmonary hypertension causes changes in pulmonary hemodynamics and is a factor for acute exacerbation and death in interstitial lung diseases (ILD). The purpose of this study was to determine the association between pulmonary hemodynamics measured by PC-MRI and episodes of acute exacerbations and death in patients with ILD related pulmonary hypertension. Reduction in right cardiac output, as detected by PC-MRI, was associated with acute exacerbation and increased mortality in ILD. MR examination to detect right ventricular dysfunction is useful for predicting the poor prognosis in fibrotic ILD patients, even if they are not combined with pulmonary hypertension.

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  • Predicting treatment effect and prognosis by using IVIM

    Grant number：26461831  2014.4 - 2017.3

    Japan Society for the Promotion of Science  Grants-in-Aid for Scientific Research  Grant-in-Aid for Scientific Research (C)

    Hatakenaka Masmaitsu

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    Grant amount：\4550000 （ Direct Cost: \3500000 、 Indirect Cost：\1050000 ）

    In total, 28 patients with head and neck cancer who were treated with (chemo)radiotherapy were enrolled in the present study. However, 8 patients were excluded due to poor image quality and/or inadequate clinical data. Further, patients with nasopharyngeal cancer were excluded because its D is lower and sensitive to chemoradiotherapy. Finally, 10 patients were statistically analyzed.
    The pre-treatment D value for 6 patients without recurrence was 0.640±0.168 mm2/s and that for 4 ones with recurrence was 0.921±0.204 mm2/s and statistically significant difference was observed (p<0.05). The ratio of D value increase at 10Gy was 0.350±0.533 without recurrence and 0.04±0.174 with recurrence but statistical significance was not observed. F(perfusion fraction) and D*(perfusion) derived from IVIM method show wide variation. Signal intensity at b=25 s/mm2 was lower than that at b=50 s/mm2 in some cases. Thus, F and D* were not analyzed.

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  • Clinical and Basic Researches of Hepatic Stem Cells onLiver Regeneration as Defense Mechanism.

    Grant number：22390259  2010 - 2012

    Ministry of Education, Culture, Sports, Science and Technology  Grants-in-Aid for Scientific Research(基盤研究(B))  基盤研究(B)

    Koichi HIRATA, Toshihiro MITAKA, Toru MIZUGUCHI, Yukio NAKAMURA, Makoto MEGURO, Masaki KAWAMOTO, Naoya YAMA, Hiroomi TATSUMI, Shigenori OTA, Masafumi IMAMURA, Hiroshi YAMAGUCHI, Takashi KOJIMA, Norimasa SAWADA

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    Authorship：Collaborating Investigator(s) (not designated on Grant-in-Aid)  Grant type：Competitive

    Grant amount：\19240000 （ Direct Cost: \14800000 、 Indirect Cost：\4440000 ）

    We have achieved the results by the clinical and basic studies.【Study 1】We developed a rat model of acute liver failure after 2/3 partial hepatectomy (PH) for non-alcoholic steatohepatitis (NASH)-related cirrhosis. The mechanism by which HT improved the survival of the model rats was examined in short- and long-term investigations. Overall survival was significantly longer in the HT group than the non-HT group (7-day survival rates: 46.7% and 7.7%, respectively). Preoperative HT might improve the survival of rats with NASH-related cirrhosis after PH by preventing the host hepatocytes from accelerating their growth and falling into apoptosis. 【Study 2】We developed software to calculate the pixels of interest in the area between the hepatic and heart curves (ABC) of 99mTc-galactocyl human serum albumin (GSA) scintigraphy. The area under the receiver operating characteristic curve (AUC) was calculated for evaluation of Child-Pugh score grade B (Child B), pathological chronic hepatitis (CH), and liver cirrhosis (LC). We developed a novel liver functional indicator, the ABC, to count radioactivity in sequence.

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