2026/02/21 更新

写真a

ヤマ　ナオヤ
山　直也
所属
医学部 放射線医学講座放射線診断学分野 准教授
職名
准教授
ホームページ
http://kaken.nii.ac.jp/d/r/20404709.ja.html
外部リンク

研究キーワード

  • 細胞移植

  • 組織肝細胞

  • 肝予備能

  • 肝再生

  • 肝臓外科学

  • 組織幹細胞

  • 肝予備機能

研究分野

  • ライフサイエンス / 消化器外科学

経歴

  • 札幌医科大学   医学部   助教

    2012年

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論文

  • Olfactory Bulb Volume and Function Recovery in Eosinophilic Chronic Rhinosinusitis. 国際誌

    Keisuke Yamamoto, Masaki Abukawa, Tsuyoshi Okuni, Mitsuhiro Nakanishi, Yuki Sakurai, Naoya Yama, Noriko Ogasawara, Ryuta Kamekura, Kenichi Takano

    The Laryngoscope   2026年2月

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    記述言語：英語   掲載種別：研究論文（学術雑誌）  

    OBJECTIVE: To evaluate perioperative changes in olfactory bulb volume (OBV) and olfactory function in patients with eosinophilic chronic rhinosinusitis (ECRS) using 3T magnetic resonance imaging (MRI) with fast imaging employing steady-state acquisition (FIESTA) sequence and to assess their associations. METHODS: This single-center, retrospective observational study included 32 patients with ECRS who underwent functional endoscopic sinus surgery. Olfactory function was assessed pre- and postoperatively using the Alinamin test, T&T olfactometer, Open Essence (OE), Odor Stick Identification Test for Japanese (OSIT-J), Visual Analog Scale (VAS), and Self-Assessment Olfactory Questionnaire (SAOQ). OBV was manually measured from FIESTA images. Logistic regression was used to identify preoperative predictors of OBV change. RESULTS: Postoperative OE, OSIT-J, VAS, and SAOQ scores improved significantly. Mean OBV increased by 10.3% postoperatively, although not statistically significant (p = 0.095). OBV change correlated with improvements in olfactory identification (OE: r = 0.404, p = 0.022; OSIT-J: r = 0.402, p = 0.022), which should be interpreted as exploratory. Multivariate analysis revealed that longer odor duration on the Alinamin test (≥ 50 s) and higher SAOQ scores predicted smaller OBV increases. CONCLUSION: OBV measurement using 3T MRI with FIESTA may provide a structural correlate of olfactory changes in ECRS. The observed correlation between OBV changes and olfactory identification suggests a potential relationship with postoperative functional recovery.

    DOI： 10.1002/lary.70415

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  • Exploring a Subpopulation of MASLD Associated With New Onset of CKD Using Supervised Clustering Techniques. 国際誌

    Itaru Hosaka, Marenao Tanaka, Tatsuya Sato, Yukinori Akiyama, Keitaro Nishizawa, Rie Matsumori, Hiroki Aida, Wataru Kawaharata, Kei Nakata, Koki Abe, Toru Suzuki, Hidemichi Kouzu, Naoya Yama, Nagisa Hanawa, Masato Furuhashi

    Hepatology research : the official journal of the Japan Society of Hepatology   2026年1月

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    記述言語：英語   掲載種別：研究論文（学術雑誌）  

    AIMS: Metabolic dysfunction-associated steatotic liver disease (MASLD) is characterized by the presence of hepatic steatosis and at least one of five cardiometabolic risk factors, leading to the development of cardiovascular-kidney-metabolic syndrome including chronic kidney disease (CKD). However, the impact of heterogeneity of MASLD on new onset of CKD remains unclear. We explored the relationship between subgroups of MASLD divided by using a machine learning (ML) model called supervised clustering and the development of CKD during a 10-year follow-up period. METHODS: A total of 12,168 Japanese subjects (men/women: 7927/4,241 and mean age: 48 years) who received annual health examinations including abdominal ultrasonography were recruited. RESULTS: Using the supervised clustering by SHapley Additive exPlanations (SHAP) and uniform manifold approximation and projection (UMAP) for steatotic liver diseases, 10 subclusters including 3 distinctive subgroups of MASLD were detected by a Gaussian mixture model. Kaplan-Meier survival curve analysis showed a significant difference in the cumulative incidence for new onset of CKD among the 3 subgroups of MASLD. Among the MASLD subclusters, an obese subgroup with an atherogenic profile of serum lipids as well as high levels of fatty liver index and uric acid was the worst subcluster for the development of CKD in individuals with MASLD. CONCLUSIONS: The supervised clustering of MASLD using a SHAP-converted matrix and UMAP reveals phenotypically distinct subpopulations that improved risk stratification for new onset of CKD. An obese subgroup with atherogenic lipid profiles and hyperuricemia in MASLD is associated with an increased risk for the development of CKD.

    DOI： 10.1111/hepr.70127

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  • The Effectiveness of Lesion Detection for Immunoglobulin G4-Related Kidney Diseases by Diffusion-Weighted Imaging. 国際誌

    Hidenori Amaike, Masatoshi Kanda, Hirotsugu Yamazaki, Koki Nakamura, Li Ma, Ken Nagahata, Hiroyuki Nakamura, Arata Osanami, Naoya Yama, Masamitsu Hatakenaka, Masato Furuhashi, Hiroki Takahashi

    Nephron   150 ( 1 )   1 - 11   2026年

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    記述言語：英語   掲載種別：研究論文（学術雑誌）  

    OBJECTIVES: The aim of the study was to compare the efficacy of magnetic resonance imaging (MRI) with that of plain or contrast-enhanced computed tomography (CT) in the detection of renal parenchymal and pelvic lesions of immunoglobulin G4-related kidney disease (IgG4-RKD). METHODS: Patients with IgG4-RKD and controls, who performed plain, contrast-enhanced CT and MRI around the kidney region in our hospital, were enrolled. The diagnosis of IgG4-RKD was made by definite cases of IgG4-RKD diagnostic criteria in 2020. Five blinded observers independently assessed image datasets by confidence scores to assess diagnostic accuracy, sensitivity, specificity, areas under the receiver operating characteristic curve (AUROC), and Cronbach's alpha coefficient. RESULTS: A total of 31 patients were included in the study. Fourteen (45.2%) had IgG4-RKD. Five patients with IgG4-RKD had parenchymal lesions, 5 had renal pelvic lesions, and 4 had both. In the parenchymal lesions, there was no significant difference in diagnostic performance between contrast-enhanced CT and diffusion-weighted imaging (DWI)-b800. The AUROC and sensitivity were higher in DWI-b800 than in plain CT (p < 0.05). Cronbach's alpha coefficient was 0.44 for plain CT and over 0.80 for contrast-enhanced CT and DWI-b800. In the pelvic lesions, there were fewer differences in the performance among each sequence. Cronbach's alpha coefficient was over 0.80 for plain CT, contrast-enhanced CT, and DWI-b800. CONCLUSION: Plain MRI, especially in DWI-b800, can effectively detect renal parenchymal lesions in IgG4-RKD. In cases where the use of a contrast agent of CT is difficult, DWI-b800 can be an alternative for the screening of IgG4-RKD.

    DOI： 10.1159/000547628

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  • Screening for lung fibrosis using serum surfactant protein-D, KL-6, and a deep learning algorithm on chest radiographs: a prospective observational study. 国際誌

    Hirotaka Nishikiori, Naoya Yama, Kenichi Hirota, Yuki Mori, Ippei Neriai, Haruka Takenaka, Atsushi Saito, Mamoru Takahashi, Koji Kuronuma, Shinichiro Ueda, Masamitsu Hatakenaka, Hirofumi Chiba

    BMC pulmonary medicine   26 ( 1 )   22 - 22   2025年12月

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    記述言語：英語   掲載種別：研究論文（学術雑誌）  

    BACKGROUND: Early identification of lung fibrosis remains difficult. In Japan, the serum biomarkers surfactant protein-D (SP-D) and KL-6 are commonly used to monitor interstitial lung diseases (ILD) in clinical practice, but their potential role in the early detection of lung fibrosis has not yet been fully clarified. Although chest radiography is also considered a possible tool for identifying subclinical pulmonary fibrosis, detecting early-stage disease remains challenging. A deep learning-based software, BMAX, was recently developed to identify fibrosing ILD on chest radiographs. Its capability to detect lung fibrosis in a health-checkup setting requires validation. METHODS: Study participants were randomly recruited from individuals undergoing routine health examinations. All participants underwent chest radiography and serum SP-D and KL-6 testing. Those with elevated biomarker levels (≥ 110 ng/mL for SP-D and ≥ 500 IU/mL for KL-6) or radiographic abnormalities were advised to undergo further evaluation with chest computed tomography (CT). Lung fibrosis on CT was assessed independently by one pulmonologist and one thoracic radiologist. BMAX assigned a confidence score for lung fibrosis (ranging from 0 to 1) on each radiograph. In participants who underwent CT, the sensitivity and specificity of BMAX (using a confidence score > 0.3 as the threshold), SP-D, and KL-6 for detecting lung fibrosis were evaluated. RESULTS: Among the 2,751 individuals enrolled, 228 were recommended for CT, and 81 underwent the scan. Lung fibrosis was identified on chest CT in 8 of the 81 participants. The positivity rates for SP-D, KL-6, and BMAX (confidence score > 0.3) were 5.9%, 2.4%, and 5.9%, respectively. SP-D showed a sensitivity of 1.000 and a specificity of 0.315, while KL-6 showed a sensitivity of 0.750 and a specificity of 0.753. BMAX demonstrated a sensitivity of 1.000 and a specificity of 0.904. CONCLUSIONS: SP-D and KL-6 may be useful screening biomarkers for lung fibrosis in health checkup settings, offering high sensitivity and moderate positivity rates. BMAX also appears promising as a standalone screening tool for detecting lung fibrosis on chest radiographs.

    DOI： 10.1186/s12890-025-04062-5

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  • An Apparent Association of Metabolic Dysfunction-Associated Steatotic Liver Disease with High Levels of Estimated Small Dense LDL Cholesterol in a Japanese Population.

    Rie Matsumori, Marenao Tanaka, Tatsuya Sato, Yukinori Akiyama, Itaru Hosaka, Kei Nakata, Wataru Kawaharata, Hiroki Aida, Keitaro Nishizawa, Hidemichi Kouzu, Naoya Yama, Nagisa Hanawa, Masato Furuhashi

    Journal of atherosclerosis and thrombosis   2025年11月

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    記述言語：英語   掲載種別：研究論文（学術雑誌）  

    AIM: Metabolic dysfunction-associated steatotic liver disease (MASLD) is associated with an increased risk of atherosclerotic cardiovascular disease (ASCVD). Although small dense low-density lipoprotein cholesterol (sdLDL-C) is a highly atherogenic lipid fraction, the association of the sdLDL-C level with MASLD and other steatotic liver disease (SLD) subcategories remain unclear. We investigated the association between various SLDs and the sdLDL-C level calculated by Sampson's equation. METHODS: A total of 15,734 Japanese participants (men/women: 10,228/5,506, mean age: 49±9 years) who underwent annual health examinations including abdominal ultrasonography were recruited after the exclusion of subjects with triglycerides ≥ 800 mg/dL. RESULTS: Among SLD subcategories including MASLD, MASLD with increased alcohol consumption (MetALD) and alcohol-associated liver disease (ALD), the mean levels of sdLDL-C and non-high-density lipoprotein cholesterol (non-HDL-C) were the highest in participants with MASLD. Triglyceride levels were significantly lower in participants with MASLD than in those with MetALD and those with ALD. After adjustment for age, sex, body mass index, current smoking and alcohol drinking habits, treatment of hypertension, diabetes and dyslipidemia, and triglyceride level, MASLD and MetALD were independently associated with sdLDL-C level, and the association was stronger in MASLD than in other SLD subcategories. The sdLDL-C level was also independently associated with each SLD subcategory after adjustment for the same covariates. The addition of sdLDL-C to traditional risk factors significantly improved the discriminatory capacity for the presence of MASLD in comparison to the addition of non-HDL-C. CONCLUSION: MASLD is independently associated with elevated estimated sdLDL-C levels in Japanese individuals, leading to an increased risk of ASCVD.

    DOI： 10.5551/jat.65939

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  • The health stage of cardiovascular-kidney-metabolic (CKM) syndrome is useful for predicting all-cause mortality in patients with type 2 diabetes: a cohort study in a period prior to the standard use of recent pharmacotherapy. 国際誌

    Keitaro Nishizawa, Marenao Tanaka, Tatsuya Sato, Tomohito Gohda, Nozomu Kamei, Maki Murakoshi, Yukinori Akiyama, Wataru Kawaharata, Hiroki Aida, Hidemichi Kouzu, Naoya Yama, Mitsunobu Kubota, Michiyoshi Sanuki, Yusuke Suzuki, Masato Furuhashi

    Journal of diabetes and its complications   39 ( 10 )   109146 - 109146   2025年10月

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    記述言語：英語   掲載種別：研究論文（学術雑誌）  

    AIM: Cardiovascular-kidney-metabolic (CKM) syndrome is a recently defined systemic condition linking cardiovascular disease, chronic kidney disease and metabolic disorders including type 2 diabetes (T2D). Although the CKM staging has been proposed for integrated risk assessment, its association with all-cause mortality in patients with T2D remains unclear. We investigated the prognosis in patients with T2D assigned by the CKM health stage. METHODS: A total of 632 Japanese patients with T2D were enrolled. The primary endpoint was all-cause death. RESULTS: The numbers of the recruited patients with stages 2, 3 and 4 were 353 (55.9 %), 116 (18.3 %) and 163 (25.8 %), respectively. During a median follow-up of 64 months (35,327 person-months), 62 patients (9.8 %) died. Kaplan-Meier survival curves analysis showed significant differences in cumulative mortality among CKM health stages (log-rank test: P < 0.001) with higher cumulative mortality in stages 3 and 4 than in stage 2. Multivariable Cox proportional hazard models after adjustment of age, sex, body mass index, current smoking habit, cancer, relevant medications and hemoglobin A1c showed that adjusted hazard ratios (HRs) [95 % confidence intervals] for all-cause death were significantly higher in patients with stages 3 (2.25[1.08-4.69]) and those with stage 4 (2.87[1.41-5.84]) than in those with stage 2 as the reference. After additional adjustment of N-terminal pro-brain natriuretic peptide and estimated glomerular filtration rate among definition criteria for staging, the association of stages with all-cause death remained statistically significant in only stage 4 (2.16[1.02-4.56]). CONCLUSION: The CKM health staging is useful for predicting all-cause mortality in Japanese patients with T2D.

    DOI： 10.1016/j.jdiacomp.2025.109146

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  • Blood-pool SUV analysis of 99mTc-galactosyl human serum albumin (99mTc-GSA) normalized by blood volume for prediction of short-term survival in severe liver failure: preliminary report.

    Naoya Yama, Hiroomi Tatsumi, Masayuki Akatsuka, Masamitsu Hatakenaka

    Annals of nuclear medicine   39 ( 1 )   58 - 67   2025年1月

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    記述言語：英語   掲載種別：研究論文（学術雑誌）  

    PURPOSE: This study evaluated the usefulness of SUV analysis of 99mTc-galactosyl human serum albumin (99mTc-GSA) scintigraphy including SUV analysis of the cardiac blood pool normalized by blood volume as a predictor of short-term survival in severe liver failure. PATIENTS AND METHODS: We enrolled 24 patients with severe liver failure who underwent 99mTc-GSA scintigraphy and were admitted to the intensive care unit. Patients were divided into survival and non-survival groups at 7, 14, and 28 days from the performance of 99mTc-GSA scintigraphy. From SPECT images we calculated SUVs of the cardiac blood pool, performing normalization for body weight, lean body weight, Japanese lean body weight, and blood volume and we calculated SUVs of the liver, normalizing by body weight, lean body weight, and Japanese lean body weight. We also calculated the uptake ratio of the heart at 15 min to that at 3 min (HH15) and the uptake ratio of the liver at 15 min to the liver plus the heart at 15 min (LHL15) from planar images of 99mTc-GSA scintigraphy. RESULTS: There were significant differences between the 7 day survival and non-survival groups for all SUVs of the heart and the liver and HH15, for 14 day survival groups in SUVs of the heart normalized by Japanese lean body weight and blood volume, and no significant differences between 28 day survival groups for any SUVs, HH15, or LHL15. Although the difference was not significant, SUV analysis of the heart normalized by blood volume showed the highest value for the area under the receiver-operating-characteristics curve for both 7 day and 14 day survival. CONCLUSION: SUV analysis of 99mTc-GSA including SUV analysis of cardiac blood pool normalized by blood volume is of value for prediction of short-term survival in cases with severe liver failure.

    DOI： 10.1007/s12149-024-01975-9

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  • Correlation between normally aerated lung and respiratory system compliance at clinical high positive end-expiratory pressure in patients with COVID-19. 国際誌

    Keishi Ogura, Ryuichi Nakayama, Naofumi Bunya, Shinshu Katayama, Naoya Yama, Yuya Goto, Keigo Sawamoto, Shuji Uemura, Eichi Narimatsu

    Scientific reports   14 ( 1 )   14477 - 14477   2024年6月

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    記述言語：英語   掲載種別：研究論文（学術雑誌）  

    Normally aerated lung tissue on computed tomography (CT) is correlated with static respiratory system compliance (Crs) at zero end-expiratory pressure. In clinical practice, however, patients with acute respiratory failure are often managed using elevated PEEP levels. No study has validated the relationship between lung volume and tissue and Crs at the applied positive end-expiratory pressure (PEEP). Therefore, this study aimed to demonstrate the relationship between lung volume and tissue on CT and Crs during the application of PEEP for the clinical management of patients with acute respiratory distress syndrome due to COVID-19. Additionally, as a secondary outcome, the study aimed to evaluate the relationship between CT characteristics and Crs, considering recruitability using the recruitment-to-inflation ratio (R/I ratio). We analyzed the CT and respiratory mechanics data of 30 patients with COVID-19 who were mechanically ventilated. The CT images were acquired during mechanical ventilation at PEEP level of 15 cmH2O and were quantitatively analyzed using Synapse Vincent system version 6.4 (Fujifilm Corporation, Tokyo, Japan). Recruitability was stratified into two groups, high and low recruitability, based on the median R/I ratio of our study population. Thirty patients were included in the analysis with the median R/I ratio of 0.71. A significant correlation was observed between Crs at the applied PEEP (median 15 [interquartile range (IQR) 12.2, 15.8]) and the normally aerated lung volume (r = 0.70 [95% CI 0.46-0.85], P < 0.001) and tissue (r = 0.70 [95% CI 0.46-0.85], P < 0.001). Multivariable linear regression revealed that recruitability (Coefficient = - 390.9 [95% CI - 725.0 to - 56.8], P = 0.024) and Crs (Coefficient = 48.9 [95% CI 32.6-65.2], P < 0.001) were significantly associated with normally aerated lung volume (R-squared: 0.58). In this study, Crs at the applied PEEP was significantly correlated with normally aerated lung volume and tissue on CT. Moreover, recruitability indicated by the R/I ratio and Crs were significantly associated with the normally aerated lung volume. This research underscores the significance of Crs at the applied PEEP as a bedside-measurable parameter and sheds new light on the link between recruitability and normally aerated lung.

    DOI： 10.1038/s41598-024-64622-3

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  • Importance of Diagnostic Imaging Training for Intensivists: Lessons Learned From a Case. 国際誌

    Masayuki Akatsuka, Akira Hasebe, Naoya Yama

    Cureus   16 ( 3 )   e55779   2024年3月

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    記述言語：英語   掲載種別：研究論文（学術雑誌）  

    Intensive care physicians are tasked with managing patients with complex organ disorders, necessitating a broad skill set and ongoing education. While simulation training often focuses on equipment handling, this case report highlights a critical instance of acute aortic dissection initially missed on imaging during intensive care unit (ICU) admission. An 86-year-old woman with multiple comorbidities presented with respiratory symptoms and electrolyte imbalances, ultimately requiring ICU admission. Despite initial inconclusive imaging and treatment for suspected conditions, further evaluation revealed a dissecting aneurysm of the descending aorta. This case underscores the importance of thorough diagnostic evaluation and ongoing vigilance, especially in older adults with multiple health conditions. It emphasizes the need for comprehensive education, including proactive training in image diagnosis, to recognize diverse medical presentations and potential complications. This case serves as a reminder of the evolving challenges in critical care and the necessity for continuous education and adaptability to ensure optimal patient outcomes.

    DOI： 10.7759/cureus.55779

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  • Bronchiolitis Obliterans With Recurrent Pneumothorax After Allogeneic Bone Marrow Transplantation. 国際誌

    Masayuki Akatsuka, Naoya Yama

    Cureus   15 ( 10 )   e46633   2023年10月

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    記述言語：英語   掲載種別：研究論文（学術雑誌）  

    Bronchiolitis obliterans syndrome (BOS) is a non-infectious pulmonary complication that can occur in patients who have undergone allogeneic bone marrow transplantation (BMT). BOS is characterized by the irreversible narrowing and obstruction of bronchi, resulting in severe respiratory distress and poor outcomes. This case report focuses on the complex management of a patient with a multifaceted medical history. A 20-year-old man was initially diagnosed with precursor B lymphoblastic lymphoma and subsequently underwent allogeneic BMT. Nine months later, the patient was diagnosed with bronchiolitis obliterans with graft-versus-host disease, resulting in the development of BOS. Remarkably, 12 years after BMT, the patient was registered for lung transplantation. However, one year after registration, the patient developed a left pneumothorax. Despite rigorous efforts, including continuous thoracic drainage and autologous pleurodesis, the pneumothorax did not respond to treatment and required video-assisted thoracic surgery (VATS) bullectomy. The preoperative assessment revealed a challenging clinical finding characterized by the need for home oxygen therapy (5 L/min with a nasal cannula), severe Hugh-Jones classification IV-V, and marked hypercapnia (partial pressure of carbon dioxide (pCO2), 76 mmHg). Imaging studies, including high-resolution computed tomography and chest radiography, revealed hyperinflation, emphysematous changes, and bronchiectasis across all lung lobes, further complicating the patient's condition. Intraoperative management had the unique challenges of persistent hypoxia (P/F ratio 65-80), positive end-expiratory pressure of 5 cmH2O, and low tidal volumes (1.6-2.0 mL/kg) during one-lung ventilation. To address these problems, both-lung ventilation had to be performed intermittently. However, hyperventilation remained unmanageable, with maximum pCO2 values reaching 140 mmHg. Following surgery, the patient had to be admitted to the intensive care unit in an intubated state. Fortunately, the following day, the patient's condition improved markedly, his state of consciousness was clear (Glasgow Coma Scale 15) and his pCO2 level improved (66 mmHg) with spontaneous breath. This course of events allowed extubation and the patient was discharged to the general ward only two days after surgery. This case highlights the critical importance of a comprehensive preoperative assessment, including advanced imaging, when managing patients with BOS and complex pulmonary complications. Furthermore, it highlights the complexity and difficulty of perioperative respiratory management in such cases.

    DOI： 10.7759/cureus.46633

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  • A suicide attempt by intramuscular injection of pentobarbital sodium into rectus abdominis suggested by computed tomography. 国際誌

    Ryuichi Nakayama, Hiroki Sato, Naoya Yama, Keishi Ogura, Ryoko Kyan, Tomoki Hanazawa, Tomohiro Yoshizawa, Masamune Miyamoto, Yoshito Kamijo, Hirotoshi Mizuno, Hirotoshi Inamura, Keisuke Harada, Shuji Uemura, Eichi Narimatsu

    Forensic science, medicine, and pathology   19 ( 2 )   198 - 201   2023年6月

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    記述言語：英語   掲載種別：研究論文（学術雑誌）  

    Suicide attempts in humans due to injections of the veterinary drug pentobarbital sodium have been rarely reported. Herein, we present a case of a suicide attempt by intramuscular injection of pentobarbital sodium into the rectus abdominis muscle, which was suggested by computed tomography (CT). A 73-year-old man was brought to the emergency department with GCS 3 (E1V1M1) and an incised wound on the right side of the neck. A bottle of Somnopentyl® (pentobarbital sodium, 64.8 mg/ml), a 20-ml empty syringe with an 18-mm needle, and no. 10 scalpel were present at the scene. At the emergency department, the patient was intubated and was admitted to the intensive care unit. A urine drug screen test by SIGNIFY® ER was positive for benzodiazepines and barbiturates, and continuous veno-venous hemofiltration (CHF) was initiated. The route of drug administration was initially unknown; however, a CT scan revealed swelling of the left rectus abdominis muscle with a wound suggestive of a needle puncture, and the CT analysis suggested 38.16 ml as the maximum dose of pentobarbital sodium. On day 3, the patient's consciousness improved, and he was weaned off CHF and mechanical ventilation. There have been several reports of postmortem CT yielding information on the site of administration of intoxicants, but there have been none for surviving intoxicated patients. This is the first report of the usefulness of CT to identify the site of administration of the causative agent of intoxication while the patient is still alive.

    DOI： 10.1007/s12024-022-00508-y

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  • Correlation between the hysteresis of the pressure-volume curve and the recruitment-to-inflation ratio in patients with coronavirus disease 2019. 国際誌

    Ryuichi Nakayama, Naofumi Bunya, Shinshu Katayama, Yuya Goto, Yusuke Iwamoto, Kenshiro Wada, Keishi Ogura, Naoya Yama, Shintaro Takatsuka, Masumi Kishimoto, Kanako Takahashi, Ryuichiro Kakizaki, Keigo Sawamoto, Shuji Uemura, Keisuke Harada, Eichi Narimatsu

    Annals of intensive care   12 ( 1 )   106 - 106   2022年11月

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    記述言語：英語   掲載種別：研究論文（学術雑誌）  

    BACKGROUND: Since the response to lung recruitment varies greatly among patients receiving mechanical ventilation, lung recruitability should be assessed before recruitment maneuvers. The pressure-volume curve (PV curve) and recruitment-to-inflation ratio (R/I ratio) can be used bedside for evaluating lung recruitability and individualing positive end-expiratory pressure (PEEP). Lung tissue recruitment on computed tomography has been correlated with normalized maximal distance (NMD) of the quasi-static PV curve. NMD is the maximal distance between the inspiratory and expiratory limb of the PV curve normalized to the maximal volume. However, the relationship between the different parameters of hysteresis of the quasi-static PV curve and R/I ratio for recruitability is unknown. METHODS: We analyzed the data of 33 patients with severe coronavirus disease 2019 (COVID-19) who received invasive mechanical ventilation. Respiratory waveform data were collected from the ventilator using proprietary acquisition software. We examined the relationship of the R/I ratio, quasi-static PV curve items such as NMD, and respiratory system compliance (Crs). RESULTS: The median R/I ratio was 0.90 [interquartile range (IQR), 0.70-1.15] and median NMD was 41.0 [IQR, 37.1-44.1]. The NMD correlated significantly with the R/I ratio (rho = 0.74, P < 0.001). Sub-analysis showed that the NMD and R/I ratio did not correlate with Crs at lower PEEP (- 0.057, P = 0.75; and rho = 0.15, P = 0.41, respectively). On the contrary, the ratio of Crs at higher PEEP to Crs at lower PEEP (Crs ratio (higher/lower)) moderately correlated with NMD and R/I ratio (rho = 0.64, P < 0.001; and rho = 0.67, P < 0.001, respectively). CONCLUSIONS: NMD of the quasi-static PV curve and R/I ratio for recruitability assessment are highly correlated. In addition, NMD and R/I ratio correlated with the Crs ratio (higher/lower). Therefore, NMD and R/I ratio could be potential indicators of recruitability that can be performed at the bedside.

    DOI： 10.1186/s13613-022-01081-x

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  • Pulmonary torsion due to omentopexy after replacement of the descending aorta and esophagectomy. 国際誌

    Masayuki Akatsuka, Naoya Yama, Yutaka Iba, Yoshiki Masuda

    Oxford medical case reports   2022 ( 11 )   omac122   2022年11月

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    記述言語：英語   掲載種別：研究論文（学術雑誌）  

    DOI： 10.1093/omcr/omac122

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  • Deep learning algorithm to detect fibrosing interstitial lung disease on chest radiographs. 国際誌

    Hirotaka Nishikiori, Koji Kuronuma, Kenichi Hirota, Naoya Yama, Tomohiro Suzuki, Maki Onodera, Koichi Onodera, Kimiyuki Ikeda, Yuki Mori, Yuichiro Asai, Yuzo Takagi, Seiwa Honda, Hirofumi Ohnishi, Masamitsu Hatakenaka, Hiroki Takahashi, Hirofumi Chiba

    The European respiratory journal   61 ( 2 )   2022年10月

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    記述言語：英語   掲載種別：研究論文（学術雑誌）  

    BACKGROUND: Antifibrotic therapies are available to treat chronic fibrosing interstitial lung diseases (CF-ILDs), including idiopathic pulmonary fibrosis. Early use of these treatments is recommended to slow deterioration of respiratory function and to prevent acute exacerbation. However, identifying patients in the early stages of CF-ILD using chest radiographs (CRs) is challenging. In this study, we developed and tested a deep learning algorithm to detect CF-ILD using CR images. METHOD: From the image archive of Sapporo Medical University Hospital, 653 CRs from 263 patients with CF-ILDs and 506 from 506 patients without CF-ILD were identified; 921 were used for deep learning and 238 were used for algorithm testing. The algorithm was designed to output a numerical score ranging from 0 to 1, representing the probability of CF-ILD. Using the testing dataset, the algorithm's capability to identify CF-ILD was compared with that of doctors. A second dataset, in which CF-ILD was confirmed using computed tomography images, was used to further evaluate the algorithm's performance. RESULTS: The area under the curve of the receiver operating characteristic curve, which indicates the algorithm's detection capability, was 0.979. Using a score cutoff of 0.267, the sensitivity and specificity of detection were 0.896 and 1.000, respectively. These data showed that the algorithm's performance was non-inferior to that of doctors, including pulmonologists and radiologists; performance was verified using the second dataset. CONCLUSIONS: We developed a deep learning algorithm to detect CF-ILDs using CR images. The algorithm's detection capability was non-inferior to that of doctors.

    DOI： 10.1183/13993003.02269-2021

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  • Diagnosis of prosthetic joint infection at the hip using the standard uptake value of three-phase 99mTc-hydroxymethylene diphosphonate SPECT/CT.

    Naoya Yama, Satoshi Nagoya, Shintaro Sugita, Masayuki Koyama, Masamitsu Hatakenaka

    Annals of nuclear medicine   36 ( 7 )   634 - 642   2022年4月

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    記述言語：英語   掲載種別：研究論文（学術雑誌）  

    DOI： 10.1007/s12149-022-01745-5

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  • Abnormal [18F]fluorodeoxyglucose accumulation to tori tubarius in IgG4-related disease.

    Ken Nagahata, Masatoshi Kanda, Ryuta Kamekura, Masanari Sugawara, Naoya Yama, Chisako Suzuki, Kenichi Takano, Masamitsu Hatakenaka, Hiroki Takahashi

    Annals of nuclear medicine   36 ( 2 )   200 - 207   2022年2月

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    記述言語：英語   掲載種別：研究論文（学術雑誌）  

    OBJECTIVES: Tubarial glands (TGs) are recently refocused gland tissues localized near the tori tubarius in the nasopharynx and their clinical relevance is not clear yet. IgG4-related disease (IgG4-RD) is a progressive fibrosing condition and salivary glands are well-affected lesions. The aim of the present study is to examine [18F]fluorodeoxyglucose ([18F]FDG) accumulation to the tori tubarius in IgG4-related disease (IgG4-RD). METHODS: 48 patients with IgG4-RD who underwent positron emission tomography (PET) scanning with [18F]FDG were included and semi-quantitative analysis of [18F]FDG accumulation to tori tubarius was performed along with the clinical features and histopathological analysis. RESULTS: Of the 48 patients, abnormal [18F]FDG accumulation (metabolic tumour volume ≥ 1) to tori tubarius was observed in 15 (31.3%), all of whom had lesions in other head and neck glands. IgG4-RD patients with abnormal [18F]FDG accumulation to tori tubarius showed swollen nasopharyngeal walls around tori tubarius and forceps biopsy of the lesion revealed acinar cells and IgG4-positive plasma cells histologically. Abnormal [18F]FDG accumulation (maximum standard uptake value, metabolic tumour volume and total lesion glycolysis) to tori tubarius correlated with higher IgG4 and lower IgA serum concentrations. CONCLUSIONS: Abnormal [18F]FDG accumulation to tori tubarius can be observed in patients with IgG4-RD and the abnormal [18F]FDG accumulation to tori tubarius can be a clue of TG involvement in IgG4-RD.

    DOI： 10.1007/s12149-021-01691-8

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  • Self-correction of a migrated power-injectable peripherally inserted central catheter following contrast-enhanced computed tomography. 国際誌

    Ryuichi Nakayama, Naofumi Bunya, Naoya Yama, Tatsuki Nonaka

    Clinical case reports   10 ( 2 )   e05385   2022年2月

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    記述言語：英語   掲載種別：研究論文（学術雑誌）  

    The use of power-injectable peripherally inserted central catheter (PIPICC) is a common practice, but displacement of these lines following injection of contrast media has been reported in 15.4% of cases. This report presents imaging evidence of displacement and self-correction of a PIPICC line following contrast-enhanced computed tomography.

    DOI： 10.1002/ccr3.5385

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  • Pneumomediastinum as patient self-inflicted lung injury in patients with acute respiratory distress syndrome due to COVID-19: a case series. 国際誌

    Rika Watanabe, Ryuichi Nakayama, Naofumi Bunya, Naoya Yama, Yusuke Iwamoto, Yoichi Katayama, Takehiko Kasai, Keigo Sawamoto, Shuji Uemura, Eichi Narimatsu

    Acute medicine & surgery   9 ( 1 )   e796   2022年

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    記述言語：英語   掲載種別：研究論文（学術雑誌）  

    BACKGROUND: In patients with coronavirus disease (COVID-19) due to severe acute respiratory syndrome coronavirus 2 infection, pneumomediastinum has been increasingly reported in cases of noninvasive oxygen therapy, including high-flow nasal cannula, and invasive mechanical ventilation. However, its pathogenesis is still not understood. CASE PRESENTATION: We report two cases of pneumomediastinum in acute respiratory distress syndrome (ARDS) caused by COVID-19. In both cases, control of spontaneous breathing with neuromuscular blocking agents resulted in resolution of pneumoperitoneum. CONCLUSION: The improvement of pneumomediastinum with control of spontaneous breathing suggested patient self-inflicted lung injury as a possible mechanism in this case series. In ARDS cases with pneumomediastinum, in addition to controlling plateau pressure with conventional lung protective ventilation, spontaneous breathing should be controlled if the patient's inspiratory effort is suspected to be strong.

    DOI： 10.1002/ams2.796

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  • Displacement of a peripherally inserted central catheter after injection of contrast media. 国際誌

    Masayuki Akatsuka, Hiroomi Tatsumi, Naoya Yama, Yoshiki Masuda

    BMJ case reports   14 ( 9 )   2021年9月

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    記述言語：英語   掲載種別：研究論文（学術雑誌）  

    DOI： 10.1136/bcr-2021-246068

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  • Therapeutic Evaluation of Computed Tomography Findings for Efficacy of Prone Ventilation in Acute Respiratory Distress Syndrome Patients with Abdominal Surgery. 国際誌

    Masayuki Akatsuka, Hiroomi Tatsumi, Naoya Yama, Yoshiki Masuda

    Journal of critical care medicine (Universitatea de Medicina si Farmacie din Targu-Mures)   6 ( 1 )   32 - 40   2020年1月

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    記述言語：英語   掲載種別：研究論文（学術雑誌）  

    INTRODUCTION: In Acute Respiratory Distress Syndrome (ARDS), the heterogeneity of lung lesions results in a mis-match between ventilation and perfusion, leading to the development of hypoxia. The study aimed to examine the association between computed tomographic (CT scan) lung findings in patients with ARDS after abdominal surgery and improved hypoxia and mortality after prone ventilation. MATERIAL AND METHODS: A single site, retrospective observational study was performed at the Sapporo Medical University School of Medicine, Sapporo, Hokkaido, Japan, between 1st January 2004 and 31st October 2018. Patients were allocated to one of two groups after CT scanning according to the presence of ground-glass opacity (GGO) or alveolar shadow with predominantly dorsal lung atelectasis (DLA) on lung CT scan images. Also, Patients were divided into a prone ventilation group and a supine ventilation group when the treatment for ARDS was started. RESULTS: We analyzed data for fifty-one patients with ARDS following abdominal surgery. CT scans confirmed GGO in five patients in the Group A and in nine patients in the Group B, and DLA in 17 patients in the Group A and nine patients in the Group B. Both GGO and DLA were present in two patients in the Group A and nine patients in the Group B. Prone ventilation significantly improved patients' impaired ratio of arterial partial pressure of oxygen to fraction of inspired oxygen from 12 h after prone positioning compared with that in the supine position. Weaning from mechanical ventilation occurred significantly earlier in the Group A with DLA vs the Group B with DLA (P < 0.001). Twenty-eight-day mortality was significantly lower for the Group A with DLA vs the Group B with DLA (P = 0.035). CONCLUSIONS: These results suggest that prone ventilation could be effective for treating patients with ARDS as showing the DLA.

    DOI： 10.2478/jccm-2020-0003

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  • 心臓交感神経イメージにおいて集積低下例ほど心臓リハビリテーションの治療効果が期待できる

    中田 潤, 藤戸 健史, 大堀 克彦, 山 直也, 矢野 俊之, 橋本 暁佳, 石合 純夫, 片野 唆敏, 本間 傑, 下村 佳奈子, 蝶野 大樹, 片寄 正樹

    日本心臓核医学会ニュースレター   21 ( 2 )   120 - 120   2019年6月

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    記述言語：日本語   出版者・発行元：日本心臓核医学会  

    医中誌

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  • Repeatability analysis of ADC histogram metrics of the uterus. 国際誌

    Koichi Onodera, Masamitsu Hatakenaka, Naoya Yama, Maki Onodera, Tsuyoshi Saito, Thomas Christian Kwee, Taro Takahara

    Acta radiologica (Stockholm, Sweden : 1987)   60 ( 4 )   526 - 534   2019年4月

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    記述言語：英語   掲載種別：研究論文（学術雑誌）  

    BACKGROUND: Recently, histogram analysis based on voxel-wise apparent diffusion coefficient (ADC) value distribution has been increasingly performed. However, few studies have been reported regarding its repeatability. PURPOSE: To evaluate the repeatability of ADC histogram metrics of the uterus in clinical magnetic resonance imaging (MRI). MATERIAL AND METHODS: Thirty-three female patients who underwent pelvic MRI including diffusion-weighted imaging (DWI) were prospectively included after providing informed consent. Two sequential DWI acquisitions with identical parameters and position were obtained. Regions of interest (ROIs) for histologically confirmed uterine lesions (five cervical and three endometrial cancers, and one endometrial hyperplasia) and normal appearing tissues (21 endometrium and 33 myometrium) were assigned on the first DWI dataset and then pasted onto the second DWI dataset. ADC histogram metrics within the ROIs were calculated and repeatability was evaluated by calculating within-subject coefficient of variance (%) (wCV (%)) and Bland-Altman plot (%). RESULTS: ADC 10%, 25%, median, 75%, 90%, maximum, mean, and entropy showed high repeatability (wCV (%) < 7, 95% limit of agreement in Bland-Altman plot (%) < ±20), followed by ADC minimum (wCV (%) = 8.12, 95% limit of agreement in Bland-Altman plot (%) < ±30). However, ADC skewness and kurtosis showed very low repeatability in all evaluations. CONCLUSION: ADC histogram metrics like ADC 10%, 25%, median, 75%, 90%, maximum, mean, and entropy are robust biomarkers and could be applicable to clinical use. However, ADC skewness and kurtosis lack robustness. Radiologists should keep these characteristics and limitations in mind when interpreting quantitative DWI.

    DOI： 10.1177/0284185118786062

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  • [Impact of Misregistration between the Myocardial Perfusion Images and CT Attenuation Correction Map on the %up Take with 17 Segments Polar Map].

    Kenta Yoshikawa, Taiki Chono, Osamu Asanuma, Naoya Yama

    Nihon Hoshasen Gijutsu Gakkai zasshi   75 ( 9 )   892 - 899   2019年

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    記述言語：日本語   掲載種別：研究論文（学術雑誌）  

    PURPOSE: Computed tomography (CT) attenuation correction of myocardial perfusion in single-photon emission computed tomography (SPECT) /CT systems is possibility of misregistration between emission and transmission scans. This study aimed to evaluate the influence of misregistration using a polar map of 17 segments model. METHODS: Using the fusion software, we assessed the magnitude and direction of misregistration in 200 consecutive myocardial perfusion SPECT images with 99mTechnetium (99mTc) tetrofosmin. After registration, CT data was shifted by ±1, ±2, and ±3 pixels along the cephalad/caudal, dorsal/ventral, and left/right axes, respectively. The registered image was compared with the shifted image. RESULTS: Misregistration between the SPECT and CT images occurred by 1-2 pixels in 127 cases (63.5%) and by 2 or more pixels in four cases (2%); the maximum misregistration was 1.2±0.4 pixels on average. The polar map scoring was most significantly affected by 3 pixel ventral shift. A ventral shift of 1 pixel affected the scores for the anterolateral and inferolateral segments, whereas a caudal shift of 1 pixel affected the scores for the anterior segment. CONCLUSION: Since the 17 segments model can evaluate the position more precisely than the five segments model, it is possible to evaluate up to 1 pixel misregistration.

    DOI： 10.6009/jjrt.2019_JSRT_75.9.892

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  • Traumatic Basilar Artery Entrapment without Longitudinal Clivus Fracture: A Case Report and Review of the Literature.

    Ayumu Yamaoka, Kei Miyata, Naofumi Bunya, Hirotoshi Mizuno, Hideto Irifune, Naoya Yama, Yukinori Akiyama, Takeshi Mikami, Masahiko Wanibuchi, Nobuhiro Mikuni

    Neurologia medico-chirurgica   58 ( 8 )   362 - 367   2018年8月

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    記述言語：英語   掲載種別：研究論文（学術雑誌）  

    In blunt cerebrovascular injury, reported traumatic basilar artery occlusions have involved dissection of the basilar artery, distal embolization due to traumatic vertebral artery dissection, or entrapment of the basilar artery into the clivus fracture. To date, however, there are no reports of traumatic basilar artery entrapment without a clivus fracture. Here, we report the first case of traumatic basilar artery occlusion caused by entrapment into an originally existing bone defect. A 67-year-old man with a history of treatment for intracranial aneurysm suffered multiple traumatic injuries in a fall. On arrival at our hospital, he presented with neurogenic shock with quadriplegia. Computed tomography (CT) showed small epidural hematoma, C4-6 cervical spinous process fracture, and Th2-3 vertebral body fracture. CT angiography revealed occlusion of the basilar artery trunk. As vertebrobasilar artery dissections and clivus fracture were not observed; however, we could not elucidate the pathology of the basilar artery occlusion. On day 4, after surgery for the cervical and thoracic lesions, he exhibited consciousness disturbance. Diffusion-weighted imaging on day 5 showed hyperintensities in the brainstem and cerebellum. Basi-parallel anatomic scanning magnetic resonance imaging showed that the basilar artery, while lacking vascular wall injuries, was tethered into the clivus. Antithrombotic therapy was performed, but the patient progressed to a locked-in state. Previous head CT before the trauma revealed a bone defect already present in the clivus. We speculated basilar artery entrapment into this preexisting bone defect. We must look for basilar artery injury in trauma patients even in the absence of clivus fracture.

    DOI： 10.2176/nmc.cr.2018-0041

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  • Clinical utility of 18F-fluorodeoxyglucose/positron emission tomography in diagnosis of immunoglobulin G4–related sclerosing sialadenitis 査読

    Kenichi Takano, Ryoto Yajima, Ryuta Kamekura, Motohisa Yamamoto, Hiroki Takahashi, Naoya Yama, Masamitsu Hatakenaka, Tetsuo Himi

    Laryngoscope   128 ( 5 )   1120 - 1125   2018年5月

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    記述言語：英語   掲載種別：研究論文（学術雑誌）   出版者・発行元：John Wiley and Sons Inc.  

    DOI： 10.1002/lary.26945

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  • The Japanese Clinical Practice Guidelines for Management of Sepsis and Septic Shock 2016 (J-SSCG 2016). 国際誌

    Osamu Nishida, Hiroshi Ogura, Moritoki Egi, Seitaro Fujishima, Yoshiro Hayashi, Toshiaki Iba, Hitoshi Imaizumi, Shigeaki Inoue, Yasuyuki Kakihana, Joji Kotani, Shigeki Kushimoto, Yoshiki Masuda, Naoyuki Matsuda, Asako Matsushima, Taka-Aki Nakada, Satoshi Nakagawa, Shin Nunomiya, Tomohito Sadahiro, Nobuaki Shime, Tomoaki Yatabe, Yoshitaka Hara, Kei Hayashida, Yutaka Kondo, Yuka Sumi, Hideto Yasuda, Kazuyoshi Aoyama, Takeo Azuhata, Kent Doi, Matsuyuki Doi, Naoyuki Fujimura, Ryota Fuke, Tatsuma Fukuda, Koji Goto, Ryuichi Hasegawa, Satoru Hashimoto, Junji Hatakeyama, Mineji Hayakawa, Toru Hifumi, Naoki Higashibeppu, Katsuki Hirai, Tomoya Hirose, Kentaro Ide, Yasuo Kaizuka, Tomomichi Kan'o, Tatsuya Kawasaki, Hiromitsu Kuroda, Akihisa Matsuda, Shotaro Matsumoto, Masaharu Nagae, Mutsuo Onodera, Tetsu Ohnuma, Kiyohiro Oshima, Nobuyuki Saito, So Sakamoto, Masaaki Sakuraya, Mikio Sasano, Norio Sato, Atsushi Sawamura, Kentaro Shimizu, Kunihiro Shirai, Tetsuhiro Takei, Muneyuki Takeuchi, Kohei Takimoto, Takumi Taniguchi, Hiroomi Tatsumi, Ryosuke Tsuruta, Naoya Yama, Kazuma Yamakawa, Chizuru Yamashita, Kazuto Yamashita, Takeshi Yoshida, Hiroshi Tanaka, Shigeto Oda

    Acute medicine & surgery   5 ( 1 )   3 - 89   2018年1月

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    記述言語：英語   掲載種別：研究論文（学術雑誌）  

    BACKGROUND AND PURPOSE: The Japanese Clinical Practice Guidelines for Management of Sepsis and Septic Shock 2016 (J-SSCG 2016), a Japanese-specific set of clinical practice guidelines for sepsis and septic shock created jointly by the Japanese Society of Intensive Care Medicine and the Japanese Association for Acute Medicine, was first released in February 2017 in Japanese. An English-language version of these guidelines was created based on the contents of the original Japanese-language version. METHODS: Members of the Japanese Society of Intensive Care Medicine and the Japanese Association for Acute Medicine were selected and organized into 19 committee members and 52 working group members. The guidelines were prepared in accordance with the Medical Information Network Distribution Service (Minds) creation procedures. The Academic Guidelines Promotion Team was organized to oversee and provide academic support to the respective activities allocated to each Guideline Creation Team. To improve quality assurance and workflow transparency, a mutual peer review system was established, and discussions within each team were open to the public. Public comments were collected once after the initial formulation of a clinical question (CQ), and twice during the review of the final draft. Recommendations were determined to have been adopted after obtaining support from a two-thirds (>66.6%) majority vote of each of the 19 committee members. RESULTS: A total of 87 CQs were selected among 19 clinical areas, including pediatric topics and several other important areas not covered in the first edition of the Japanese guidelines (J-SSCG 2012). The approval rate obtained through committee voting, in addition to ratings of the strengths of the recommendation and its supporting evidence were also added to each recommendation statement. We conducted meta-analyses for 29 CQs. Thirty seven CQs contained recommendations in the form of an expert consensus due to insufficient evidence. No recommendations were provided for 5 CQs. CONCLUSIONS: Based on the evidence gathered, we were able to formulate Japanese-specific clinical practice guidelines that are tailored to the Japanese context in a highly transparent manner. These guidelines can easily be used not only by specialists, but also by non-specialists, general clinicians, nurses, pharmacists, clinical engineers, and other healthcare professionals.

    DOI： 10.1002/ams2.322

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  • The Japanese Clinical Practice Guidelines for Management of Sepsis and Septic Shock 2016 (J-SSCG 2016). 国際誌

    Osamu Nishida, Hiroshi Ogura, Moritoki Egi, Seitaro Fujishima, Yoshiro Hayashi, Toshiaki Iba, Hitoshi Imaizumi, Shigeaki Inoue, Yasuyuki Kakihana, Joji Kotani, Shigeki Kushimoto, Yoshiki Masuda, Naoyuki Matsuda, Asako Matsushima, Taka-Aki Nakada, Satoshi Nakagawa, Shin Nunomiya, Tomohito Sadahiro, Nobuaki Shime, Tomoaki Yatabe, Yoshitaka Hara, Kei Hayashida, Yutaka Kondo, Yuka Sumi, Hideto Yasuda, Kazuyoshi Aoyama, Takeo Azuhata, Kent Doi, Matsuyuki Doi, Naoyuki Fujimura, Ryota Fuke, Tatsuma Fukuda, Koji Goto, Ryuichi Hasegawa, Satoru Hashimoto, Junji Hatakeyama, Mineji Hayakawa, Toru Hifumi, Naoki Higashibeppu, Katsuki Hirai, Tomoya Hirose, Kentaro Ide, Yasuo Kaizuka, Tomomichi Kan'o, Tatsuya Kawasaki, Hiromitsu Kuroda, Akihisa Matsuda, Shotaro Matsumoto, Masaharu Nagae, Mutsuo Onodera, Tetsu Ohnuma, Kiyohiro Oshima, Nobuyuki Saito, So Sakamoto, Masaaki Sakuraya, Mikio Sasano, Norio Sato, Atsushi Sawamura, Kentaro Shimizu, Kunihiro Shirai, Tetsuhiro Takei, Muneyuki Takeuchi, Kohei Takimoto, Takumi Taniguchi, Hiroomi Tatsumi, Ryosuke Tsuruta, Naoya Yama, Kazuma Yamakawa, Chizuru Yamashita, Kazuto Yamashita, Takeshi Yoshida, Hiroshi Tanaka, Shigeto Oda

    Journal of intensive care   6   7 - 7   2018年

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    記述言語：英語   掲載種別：研究論文（学術雑誌）  

    BACKGROUND AND PURPOSE: The Japanese Clinical Practice Guidelines for Management of Sepsis and Septic Shock 2016 (J-SSCG 2016), a Japanese-specific set of clinical practice guidelines for sepsis and septic shock created jointly by the Japanese Society of Intensive Care Medicine and the Japanese Association for Acute Medicine, was first released in February 2017 and published in the Journal of JSICM, [2017; Volume 24 (supplement 2)] 10.3918/jsicm.24S0001 and Journal of Japanese Association for Acute Medicine [2017; Volume 28, (supplement 1)] http://onlinelibrary.wiley.com/doi/10.1002/jja2.2017.28.issue-S1/issuetoc.This abridged English edition of the J-SSCG 2016 was produced with permission from the Japanese Association of Acute Medicine and the Japanese Society for Intensive Care Medicine. METHODS: Members of the Japanese Society of Intensive Care Medicine and the Japanese Association for Acute Medicine were selected and organized into 19 committee members and 52 working group members. The guidelines were prepared in accordance with the Medical Information Network Distribution Service (Minds) creation procedures. The Academic Guidelines Promotion Team was organized to oversee and provide academic support to the respective activities allocated to each Guideline Creation Team. To improve quality assurance and workflow transparency, a mutual peer review system was established, and discussions within each team were open to the public. Public comments were collected once after the initial formulation of a clinical question (CQ) and twice during the review of the final draft. Recommendations were determined to have been adopted after obtaining support from a two-thirds (> 66.6%) majority vote of each of the 19 committee members. RESULTS: A total of 87 CQs were selected among 19 clinical areas, including pediatric topics and several other important areas not covered in the first edition of the Japanese guidelines (J-SSCG 2012). The approval rate obtained through committee voting, in addition to ratings of the strengths of the recommendation, and its supporting evidence were also added to each recommendation statement. We conducted meta-analyses for 29 CQs. Thirty-seven CQs contained recommendations in the form of an expert consensus due to insufficient evidence. No recommendations were provided for five CQs. CONCLUSIONS: Based on the evidence gathered, we were able to formulate Japanese-specific clinical practice guidelines that are tailored to the Japanese context in a highly transparent manner. These guidelines can easily be used not only by specialists, but also by non-specialists, general clinicians, nurses, pharmacists, clinical engineers, and other healthcare professionals.

    DOI： 10.1186/s40560-017-0270-8

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  • Three cases of implantation of a SureScan® system and MRI for investigating causes of pain.

    Kazunobu Takahashi, Atsushi Sawada, Soshi Iwasaki, Naoya Yama, Hiroyuki Takashima, Maki Onodera, Masamitsu Hatakenaka, Michiaki Yamakage

    Journal of anesthesia   31 ( 6 )   915 - 917   2017年12月

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    記述言語：英語   掲載種別：研究論文（学術雑誌）  

    We report three cases of implantation of the SureScan® system and magnetic resonance imaging (MRI) for investigating causes of pain. Although there were metal-induced artifacts on the MR images of 2 patients, the artifacts did not affect the images of structures that needed to be assessed to make the diagnosis. The SureScan® system enabled patients implanted with spinal cord stimulation devices to undergo MRI.

    DOI： 10.1007/s00540-017-2413-4

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  • Cerebral air embolism associated with penetrating lung injury: a case report and review of the literature. 国際誌

    Ayumu Yamaoka, Kei Miyata, Eichi Narimatsu, Eiji Sakawaki, Sonoko Sakawaki, Suguru Hirayama, Shuji Uemura, Naoya Yama

    Acute medicine & surgery   4 ( 2 )   213 - 216   2017年4月

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    記述言語：英語   掲載種別：研究論文（学術雑誌）  

    CASE: A 44-year-old man intentionally stabbed himself in the anterior neck and left thorax with a fruit knife. Physical examination revealed two open wounds entering the thoracic cavity in the front chest, and a stab wound entering the trachea at the neck. Two chest tubes were initially inserted for the left lung injury with open hemopneumothorax. Nevertheless, the worsening oxygenation required positive pressure ventilation (PPV) with endotracheal intubation. OUTCOME: Right hemiparesis was found during weaning from PPV. Magnetic resonance imaging revealed multiple infarctions in the area of the bifrontal and right temporal lobes. Cerebral air embolism (CAE) was strongly suspected from the imaging findings and clinical course. CONCLUSION: We concluded that mechanical ventilation was strongly involved in the occurrence of CAE. If delayed abnormal neurological findings are observed in patients with penetrating lung injuries receiving PPV management, CAE should be considered.

    DOI： 10.1002/ams2.250

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  • Improvement in automated quantitation of myocardial perfusion abnormality by using iterative reconstruction image in combination with resolution recovery, attenuation and scatter corrections for the detection of coronary artery disease. 査読

    Chono T, Onoguchi M, Shibutani T, Hashimoto A, Nakata T, Yama N, Tsuchihashi K, Hatakenaka M

    Annals of nuclear medicine   31 ( 2 )   181 - 189   2017年2月

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  • The signal intensity ratio of the optic nerve to ipsilateral frontal white matter is of value in the diagnosis of acute optic neuritis 査読

    Maki Onodera, Naoya Yama, Masato Hashimoto, Takaharu Shonai, Kazunori Aratani, Hiroyuki Takashima, Ken-ichi Kamo, Hiroshi Nagahama, Hiroshi Ohguro, Masamitsu Hatakenaka

    EUROPEAN RADIOLOGY   26 ( 8 )   2640 - 2645   2016年8月

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    記述言語：英語   掲載種別：研究論文（学術雑誌）  

    DOI： 10.1007/s00330-015-4114-4

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  • 経皮的気管切開術施行時の腕頭動脈異常走行例の経験

    君島 知彦, 升田 好樹, 巽 博臣, 後藤 京子, 名和 由布子, 山 直也, 山蔭 道明, 今泉 均

    日本集中治療医学会雑誌   23 ( 2 )   179 - 180   2016年

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    記述言語：日本語   出版者・発行元：一般社団法人 日本集中治療医学会  

    その他リンク： http://search.jamas.or.jp/link/ui/2016251654

    DOI： 10.3918/jsicm.23.179

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  • An adolescent case of familial hyperparathyroidism with a germline frameshift mutation of the CDC73 gene.

    Takako Takeuchi, Yuko Yoto, Takeshi Tsugawa, Hotaka Kamasaki, Atsushi Kondo, Jiro Ogino, Tadashi Hasegawa, Naoya Yama, Sawa Anan, Shinya Uchino, Aki Ishikawa, Akihiro Sakurai, Hiroyuki Tsutsumi

    Clinical pediatric endocrinology : case reports and clinical investigations : official journal of the Japanese Society for Pediatric Endocrinology   24 ( 4 )   185 - 9   2015年10月

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    記述言語：英語   掲載種別：研究論文（学術雑誌）  

    A 13-yr-old boy who complained of persistent nausea, vomiting and weight loss had hypercalcemia and an elevated intact PTH level. Computed tomography confirmed two tumors in the thyroid gland. The tumors were surgically removed and pathologically confirmed as parathyroid adenoma. Because his maternal aunt and grandmother both had histories of parathyroid tumors, genetic investigation was undertaken for him, and a germline frameshift mutation of the CDC73 gene was identified. CDC73 gene analysis should be done on individuals who are at risk of familial hyperparathyroidism, including those who are asymptomatic, and they should be followed for potential primary hyperparathyroidism and associated disorders including resultant parathyroid carcinoma.

    DOI： 10.1297/cpe.24.185

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  • Asialoglycoprotein receptor scintigraphy with Tc-99m-galactosyl human serum albumin (Tc-99m-GSA) as an early predictor of survival in acute liver failure 査読

    H. Tatsumi, Y. Masuda, H. Imaizumi, S. Yoshida, K. Goto, N. Yama, T. Mizuguchi, K. Hirata

    ANAESTHESIA AND INTENSIVE CARE   41 ( 4 )   523 - 528   2013年7月

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    記述言語：英語   掲載種別：研究論文（学術雑誌）  

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  • 腎被膜原発平滑筋腫の1例

    北川 未央, 玉川 光春, 兵頭 秀樹, 兵頭 かずさ, 山 直也, 河合 有里子, 佐藤 大志, 荒谷 和紀, 小野寺 麻希, 笠原 理子, 鷲尾 嘉一, 斎藤 正人, 晴山 雅人, 舛森 直哉, 塚本 泰司

    Japanese Journal of Radiology   31 ( Suppl.I )   7 - 7   2013年2月

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    記述言語：日本語   出版者・発行元：(公社)日本医学放射線学会  

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  • MRIによる前立腺癌の浸潤進展度の評価

    荒谷 和紀, 玉川 光春, 兵頭 秀樹, 兵頭 かずさ, 山 直也, 河合 有里子, 佐藤 大志, 小野寺 麻希, 笠原 理子, 鷲尾 嘉一, 斎藤 正人, 北川 未央, 晴山 雅人, 田中 俊明, 舛森 直哉, 塚本 泰司

    Japanese Journal of Radiology   31 ( Suppl.I )   7 - 7   2013年2月

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    記述言語：日本語   出版者・発行元：(公社)日本医学放射線学会  

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  • 喉頭癌における軟骨浸潤に対する画像評価

    北川 未央, 玉川 光春, 兵頭 秀樹, 兵頭 かずさ, 山 直也, 河合 有里子, 佐藤 大志, 荒谷 和紀, 小野寺 麻希, 笠原 理子, 鷲尾 嘉一, 斎藤 正人, 浅井 真友美, 晴山 雅人, 氷見 徹夫

    Japanese Journal of Radiology   31 ( Suppl.I )   16 - 16   2013年2月

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    記述言語：日本語   出版者・発行元：(公社)日本医学放射線学会  

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  • 脊髄障害を来したparaffinomaの1例

    小野寺 耕一, 荒谷 和紀, 玉川 光春, 兵頭 秀樹, 兵頭 かずさ, 山 直也, 河合 有里子, 佐藤 大志, 小野寺 麻希, 笠原 理子, 鷲尾 嘉一, 齋藤 正人, 浅井 真友美, 北川 未央, 晴山 雅人

    Japanese Journal of Radiology   31 ( Suppl.I )   16 - 16   2013年2月

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    記述言語：日本語   出版者・発行元：(公社)日本医学放射線学会  

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  • A retrospective study on the transition of radiation dose rate and iodine distribution in patients with I-131-treated well-differentiated thyroid cancer to improve bed control shorten isolation periods 査読

    Naoya Yama, Koh-ichi Sakata, Hideki Hyodoh, Mitsuharu Tamakawa, Masato Hareyama

    ANNALS OF NUCLEAR MEDICINE   26 ( 5 )   390 - 396   2012年6月

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    記述言語：英語   掲載種別：研究論文（学術雑誌）  

    DOI： 10.1007/s12149-012-0586-3

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  • 喉頭癌の軟骨浸潤の評価

    北川 未央, 玉川 光春, 兵頭 秀樹, 兵頭 かずさ, 山 直也, 佐藤 大志, 河合 友里子, 晴山 雅人, 畠中 正光, 長谷川 匡

    日本医学放射線学会学術集会抄録集   71回   S339 - S339   2012年2月

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    記述言語：日本語   出版者・発行元：(公社)日本医学放射線学会  

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  • 札幌医科大学における法医Ai

    佐藤 大志, 兵頭 秀樹, 茅橋 正憲, 高田 優, 浅井 真友美, 鷲尾 嘉一, 笠原 理子, 荒谷 和紀, 河合 有里子, 山 直也, 兵頭 かずさ, 玉川 光春, 晴山 雅人, 松本 博志

    Japanese Journal of Radiology   30 ( Suppl.I )   10 - 10   2012年2月

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    記述言語：日本語   出版者・発行元：(公社)日本医学放射線学会  

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  • Aiで同定された内因性くも膜下出血 病理解剖所見との対比

    北川 未央, 兵頭 秀樹, 佐藤 大志, 兵頭 かずさ, 山 直也, 河合 有里子, 荒谷 和紀, 笠原 理子, 鷲尾 嘉一, 浅井 真由美, 玉川 光春, 晴山 雅人, 成松 英智, 宮田 圭, 蕨 玲子

    日本医学放射線学会秋季臨床大会抄録集   46回   S510 - S510   2010年8月

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    記述言語：日本語   出版者・発行元：(公社)日本医学放射線学会  

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  • 左SVCに還流した部分肺静脈還流異常の1例

    三浦 勝利, 兵頭 秀樹, 秋葉 英成, 玉川 光春, 兵頭 かずさ, 山 直也, 河合 有里子, 佐藤 大志, 小野寺 麻紀, 荒谷 和紀, 浅井 真友美, 晴山 雅人, 石田 禎夫, 安井 寛

    日独医報   54 ( 1 )   77 - 78   2009年2月

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    記述言語：日本語   出版者・発行元：バイエル薬品(株)  

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  • Assessment of Dural Arteriovenous Fistulas of the Cavernous Sinuses on 3D Dynamic MR Angiography 査読

    H. Akiba, M. Tamakawa, H. Hyodoh, K. Hyodoh, T. Nonaka, Y. Minamida, M. Hashimoto, M. Hareyama

    AMERICAN JOURNAL OF NEURORADIOLOGY   29 ( 9 )   1652 - 1657   2008年10月

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    記述言語：英語   掲載種別：研究論文（学術雑誌）  

    DOI： 10.3174/ajnr.A1187

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  • Technetium Tc 99m methylene diphosphonate bone scintigraphy of rhabdomyolysis after near-drowning in cold seawater 査読

    Naoya Yama, Kazumitsu Koito, Kenji Fujimori, Masato Hareyama, Seiji Yoneta, Satoshi Nara, Yoshihiko Kurimoto, Eichi Narimatsu, Yasufumi Asai

    AMERICAN JOURNAL OF EMERGENCY MEDICINE   25 ( 7 )   848 - 850   2007年9月

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  • Double-subtraction maximum intensity projection MR angiography for detecting the artery of Adamkiewicz and differentiating it from the drainage vein 査読

    Hideki Hyodoh, Ryuji Shirase, Hidenari Akiba, Mitsuharu Tamakawa, Kazusa Hyodoh, Naoya Yama, Takaharu Shonai, Masato Hareyama

    JOURNAL OF MAGNETIC RESONANCE IMAGING   26 ( 2 )   359 - 365   2007年8月

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    記述言語：英語   掲載種別：研究論文（学術雑誌）  

    DOI： 10.1002/jmri.21024

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  • 【あなたのそばにもIPMN】こうみえるIPMN 放射線学的画像診断

    小井戸 一光, 廣川 直樹, 佐藤 大志, 斉藤 正人, 山 直也, 晴山 雅人, 西田 睦

    消化器内視鏡   19 ( 8 )   1081 - 1087   2007年8月

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    記述言語：日本語   出版者・発行元：(株)東京医学社  

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  • The value of multidetector row computed tomography in the diagnosis of traumatic clivus epidural hematoma in children: A three-year experience 査読

    Naoya Yama, Hitoshi Kano, Satoshi Nara, Yoshihiko Kurimoto, Eichi Narimatsu, Kazumitsu Koito, Yasufumi Asai, Masato Hareyama

    JOURNAL OF TRAUMA-INJURY INFECTION AND CRITICAL CARE   62 ( 4 )   898 - 901   2007年4月

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    記述言語：英語   掲載種別：研究論文（学術雑誌）  

    DOI： 10.1097/01.ta.0000221058.72995.c9

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  • Out-of-hospital cardiopulmonary arrest due to penetrating cardiac injury treated by percutaneous cardiopulmonary support in the emergency room: Report of a case 査読

    Yoshihiko Kurimoto, Hitoshi Kano, Naoya Yama, Satoshi Nara, Mamoru Hase, Yasufumi Asai

    SURGERY TODAY   37 ( 3 )   240 - 242   2007年3月

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    記述言語：英語   掲載種別：研究論文（学術雑誌）  

    DOI： 10.1007/s00595-006-3373-8

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  • 【膵疾患の画像診断 最近のトレンド】膵疾患の超音波診断 最近の進歩

    小井戸 一光, 廣川 直樹, 堀 正和, 佐藤 大志, 宇佐見 陽子, 山 直也, 晴山 雅人, 西田 睦

    臨床画像   22 ( 12 )   1323 - 1333   2006年12月

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    記述言語：日本語   出版者・発行元：(株)メジカルビュー社  

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  • Blind subxiphold pericardiotomy for cardiac tamponade because of acute hemopericardium 査読

    Yoshihiko Kurimoto, Mamoru Hase, Satoshi Nara, Naoya Yama, Nobuyoshi Kawaharada, Kiyofumi Morishita, Tetsuya Higami, Yasufumi Asai

    JOURNAL OF TRAUMA-INJURY INFECTION AND CRITICAL CARE   61 ( 3 )   582 - 585   2006年9月

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    記述言語：英語   掲載種別：研究論文（学術雑誌）  

    DOI： 10.1097/01.ta.0000236060.37952.ce

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  • Initial experiences in management of blunt aortic injury taking associated brain injury into consideration 査読

    Y Kurimoto, K Morishita, N Kawaharada, J Fukada, Y Hachiro, Y Fujisawa, T Saitoh, N Yama, M Hase, E Narimatsu, Y Asai

    CIRCULATION JOURNAL   70 ( 2 )   198 - 201   2006年2月

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    記述言語：英語   掲載種別：研究論文（学術雑誌）  

    DOI： 10.1253/circj.70.198

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  • Nominal free air in the left inguinal fossa due to perforation of the sigmoid colon in a case of blunt abdominal trauma: CT diagnosis 査読

    N Yama, Y Kimura, H Tatsumi, C Kihara, Y Kurimoto, E Narimatsu, H Ura, K Koito, Y Asai, K Hirata, M Hreyama

    ABDOMINAL IMAGING   31 ( 1 )   57 - 58   2006年1月

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    記述言語：英語   掲載種別：研究論文（学術雑誌）  

    DOI： 10.1007/s00261-005-0349-x

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  • Tumors of bone and soft tissue

    Mitsuharu Tamagawa, H. Akiba, H. Hyodoh, K. Hyodoh, N. Yama, Y. Kawaai, T. Sato, M. Hareyama

    Japanese Journal of Clinical Radiology   51 ( 2 )   255 - 267   2006年

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  • Preliminary report of contrast-enhanced computed tomography for patients with a percutaneous cardiopulmonary support system 査読

    N Yama, Y Takeyama, K Tanno, S Nara, Y Itoh, K Mori, M Hase, Y Kurimoto, E Narimatsu, K Koito, Y Asai, M Hareyama

    JOURNAL OF COMPUTER ASSISTED TOMOGRAPHY   29 ( 6 )   760 - 764   2005年11月

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    記述言語：英語   掲載種別：研究論文（学術雑誌）  

    DOI： 10.1097/01.rct.0000181721.77221.84

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  • Tracheal bronchus mimicking bronchial intubation endoscopically: report of a case with airway burn 査読

    N Yama, K Koito, M Hareyama, S Nara, H Okamoto, Y Kurimoto, E Narimatsu, Y Asai

    AMERICAN JOURNAL OF EMERGENCY MEDICINE   23 ( 6 )   815 - 816   2005年10月

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  • 経過観察中に膵管癌発見の契機となった超音波所見の検討

    西田 睦, 小井戸 一光, 廣川 直樹, 佐藤 大志, 河合 有里子, 染谷 正則, 庄内 孝春, 山 直也, 兵頭 秀樹, 晴山 雅人, 白石 祐子, 新山 智美, 木村 もと子, 今井 希一

    超音波医学   32 ( 5 )   479 - 479   2005年9月

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    記述言語：日本語   出版者・発行元：(公社)日本超音波医学会  

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  • Localization of intestinal bleeding using a fusion of Tc-99m-labeled RBC SPELT and X-ray CT 査読

    N Yama, E Ezoe, Y Kimura, M Mukaiya, K Fujimori, Y Kurimoto, K Koito, K Hirata, M Hareyama, Y Asai

    CLINICAL NUCLEAR MEDICINE   30 ( 7 )   488 - 489   2005年7月

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  • A paratracheal cystic lesion in a patient with potential high-energy trauma 査読

    E Narimatsu, N Yama, W Danjoh, Y Kurimoto, Y Asai

    JOURNAL OF EMERGENCY MEDICINE   28 ( 3 )   333 - 335   2005年4月

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    記述言語：英語   掲載種別：研究論文（学術雑誌）  

    DOI： 10.1016/j.jemermed.2004.08.023

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  • Enhanced sonography using carbon dioxide gas for small hepatocellular carcinoma: A comparison study between pure carbon dioxide gas and carbon dioxide microbubbles 査読

    Kazumitsu Koito, Tsutomu Namieno, Naoki Hirokawa, Takeshi Ichimura, Mutsumi Nishida, Naoya Yama, Koichi Sakata, Masato Hareyama, Motoi Nishi

    Radiation Medicine - Medical Imaging and Radiation Oncology   23 ( 2 )   104 - 110   2005年3月

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    記述言語：英語   掲載種別：研究論文（学術雑誌）   出版者・発行元：2  

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  • 造影エコーによるUAE治療効果判定

    佐藤 大志, 小井戸 一光, 廣川 直樹, 西田 睦, 山 直也, 染谷 正則, 兵頭 秀樹, 晴山 雅人

    超音波医学   32 ( 2 )   203 - 203   2005年3月

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    記述言語：日本語   出版者・発行元：(公社)日本超音波医学会  

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  • 肝・胆・膵領域におけるdifferential Tissue Harmonic Imagingの有用性の検討

    西田 睦, 小井戸 一光, 廣川 直樹, 佐藤 大志, 河合 有里子, 染谷 正則, 庄内 孝春, 中田 健生, 山 直也, 兵頭 秀樹, 晴山 雅人, 市村 健, 川岸 哲也

    超音波医学   32 ( 2 )   201 - 201   2005年3月

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    記述言語：日本語   出版者・発行元：(公社)日本超音波医学会  

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  • A case of anomalous subaortic left brachiocephalic vein mimicking mediastinal hematoma 査読

    N Yama, S Nara, Y Itoh, Y Kurimoto, E Narimatsu, Y Asai, K Koito, M Hareyama

    JOURNAL OF TRAUMA-INJURY INFECTION AND CRITICAL CARE   58 ( 2 )   419 - 420   2005年2月

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    記述言語：英語   掲載種別：研究論文（学術雑誌）  

    DOI： 10.1097/01.TA.0000142161.17648.FE

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  • Phase shift due to inversion recovery process and chemical shift effect in inversion recovery prepared gradient-echo magnetic resonance imaging 査読

    Naoya Yama, Miki Takeda, Mitsuharu Tamakawa, Hidenari Akiba, Kazumitsu Koito, Masato Hareyama

    Radiation Medicine - Medical Imaging and Radiation Oncology   23 ( 1 )   56 - 60   2005年2月

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    記述言語：英語   掲載種別：研究論文（学術雑誌）   出版者・発行元：1  

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  • 頸部リンパ節良悪性鑑別のための新しい造影エコー法Micro Flow Imaging

    小井戸 一光, 西田 睦, 市村 健, 廣川 直樹, 河合 有里子, 染谷 正則, 庄内 孝春, 中田 健生, 山 直也, 兵頭 秀樹

    超音波医学   32 ( 1 )   32 - 32   2005年1月

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    記述言語：日本語   出版者・発行元：(公社)日本超音波医学会  

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  • 自己免疫性膵炎の治療効果と増悪の判定に造影超音波が有用であった一例

    小井戸 一光, 市村 健, 廣川 直樹, 西田 睦, 河合 有里子, 染谷 正則, 庄内 孝春, 中田 健生, 山 直也, 兵頭 秀樹

    超音波医学   32 ( 1 )   33 - 33   2005年1月

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    記述言語：日本語   出版者・発行元：(公社)日本超音波医学会  

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  • 造影超音波検査による進行膵管癌の治療効果判定 CD34抗体による免疫染色との対比検討

    西田 睦, 小井戸 一光, 市村 健, 廣川 直樹, 中田 健生, 染谷 正則, 庄内 孝春, 山 直也, 兵頭 秀樹, 晴山 雅人, 木村 幸子, 佐藤 昌昭, 大谷 静治

    超音波医学   32 ( 1 )   23 - 23   2005年1月

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    記述言語：日本語   出版者・発行元：(公社)日本超音波医学会  

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  • MDCTによる膵癌・胆管癌の進展度診断 切除例での検討

    市村 健, 小井戸 一光, 廣川 直樹, 西田 睦, 秋葉 英成, 玉川 光春, 兵頭 秀樹, 兵頭 かずさ, 武 美貴, 山 直也, 庄内 孝春, 佐藤 大志, 土本 正, 晴山 雅人, 平野 透

    日本医学放射線学会雑誌   64 ( 8 )   580 - 580   2004年11月

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    記述言語：日本語   出版者・発行元：(公社)日本医学放射線学会  

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  • A simple but useful method of screening for mesenteric ischemia secondary to acute aortic dissection 査読

    Y Kurimoto, K Morishita, J Fukada, N Kawaharada, K Komatsu, N Yama, Y Asai, T Abe

    SURGERY   136 ( 1 )   42 - 46   2004年7月

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    記述言語：英語   掲載種別：研究論文（学術雑誌）  

    DOI： 10.1016/j.surg.2003.12.019

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  • 【単純・X線/CT これを見落としてはいけない】小腸 外傷性消化管穿孔

    山 直也, 浦 英樹, 佐藤 大志, 廣川 直樹, 西田 睦, 小井戸 一光, 晴山 雅人, 江副 英理, 鹿野 恒, 栗本 義彦, 成松 英智, 浅井 康文

    消化器の臨床   7 ( 3 )   246 - 248   2004年6月

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    記述言語：日本語   出版者・発行元：(株)ヴァンメディカル  

    医中誌

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  • Placement of arterial sheath for endovascular management in multiple trauma 査読

    N Yama, T Ichimura, N Hirokawa, K Koito, M Hareyama, Y Naito, S Sasaki, Y Yonemasu, Y Asai

    AMERICAN JOURNAL OF EMERGENCY MEDICINE   22 ( 3 )   245 - 246   2004年5月

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  • 造影超音波による肝血流評価 造影超音波の後期相が診断に有用であった肝結節性病変の1例

    西田 睦, 小井戸 一光, 市村 健, 廣川 直樹, 堀 正和, 中田 健生, 山 直也, 庄内 孝春, 兵頭 秀樹, 晴山 雅人, 小関 至, 高木 秀安, 佐々木 茂, 今井 浩三, 池田 英之, 佐藤 昌明, 神代 正道

    北海道医学雑誌   79 ( 2 )   206 - 206   2004年4月

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    記述言語：日本語   出版者・発行元：北海道医学会  

    医中誌

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  • 肝腫瘤性血流の経時的変化 造影超音波にて興味ある造影効果を示した硬化型肝細胞癌の1例

    西田 睦, 小井戸 一光, 市村 健, 廣川 直樹, 佐藤 大志, 中田 健生, 山 直也, 庄内 孝春, 兵頭 秀樹, 玉川 光春, 晴山 雅人, 小関 至, 高木 秀安, 佐々木 茂, 今井 浩三, 木村 幸子, 佐藤 昌明

    北海道医学雑誌   79 ( 2 )   201 - 201   2004年4月

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    記述言語：日本語   出版者・発行元：北海道医学会  

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  • 造影超音波の後期相が診断に有用であった肝結節性病変の1例

    西田 睦, 小井戸 一光, 市村 健, 廣川 直樹, 中田 健生, 山 直也, 庄内 孝春

    超音波検査技術   29 ( 2 )   208 - 208   2004年4月

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  • Pericardial hemorrhage secondary during computed tomography scanning for aortic dissecting aneurysm 査読

    N Yama, H Hyhodo, K Koito, M Hareyama, N Kawaharada, K Morishita, T Abe, Y Takeyama, Y Kurimoto, Y Itoh, Y Asai

    AMERICAN JOURNAL OF EMERGENCY MEDICINE   21 ( 6 )   512 - 513   2003年10月

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  • Assessment of stent-grafting for aortic dissection using multislice computed tomography 査読

    Y Kurimoto, N Yama, K Morishita, Y Asai, T Abe

    ANNALS OF THORACIC SURGERY   76 ( 3 )   947 - 947   2003年9月

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  • Thoracic involvement of type A aortic dissection and intramural hematoma: Diagnostic accuracy - Comparison of emergency helical CT and surgical findings 査読

    S Yoshida, H Akiba, M Tamakawa, N Yama, M Hareyama, K Morishita, T Abe

    RADIOLOGY   228 ( 2 )   430 - 435   2003年8月

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    記述言語：英語   掲載種別：研究論文（学術雑誌）  

    DOI： 10.1148/radiol.2282012162

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  • 造影超音波による腎動静脈瘻・脾動脈瘤塞栓術の治療効果判定

    西田 睦, 市村 健, 廣川 直樹, 小井戸 一光, 中田 健生, 山 直也, 庄内 孝春, 兵頭 秀樹, 晴山 雅人, 奈良 和彦

    超音波医学   30 ( 4 )   J565 - J566   2003年7月

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    記述言語：日本語   出版者・発行元：(公社)日本超音波医学会  

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  • 退形成性膵管癌の1例

    小島 一男, 小井戸 一光, 市村 健, 廣川 直樹, 西田 睦, 中田 健生, 染谷 正則, 庄内 孝春, 山 直也, 兵頭 秀樹, 晴山 雅人, 木村 弘通, 山 光進

    超音波医学   30 ( 4 )   J571 - J571   2003年7月

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    記述言語：日本語   出版者・発行元：(公社)日本超音波医学会  

    医中誌

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  • ワークフロートコントロールシステムを用いた腹部造影超音波検査

    市村 健, 小井戸 一光, 廣川 直樹, 西田 睦, 中田 健生, 染谷 正則, 庄内 孝春, 山 直也, 兵頭 秀樹, 晴山 雅人, 佐野 明洋, 神山 直久, 小笠原 洋一

    超音波医学   30 ( 4 )   J566 - J567   2003年7月

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    記述言語：日本語   出版者・発行元：(公社)日本超音波医学会  

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  • Emergency endovascular stent-grafting for infected pseudoaneurysm of brachial artery 査読

    Y Kurimoto, Y Tsuchida, J Saito, N Yama, E Narimatsu, Y Asai

    INFECTION   31 ( 3 )   186 - 188   2003年6月

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    記述言語：英語   掲載種別：研究論文（学術雑誌）  

    DOI： 10.1007/s15010-002-3046-5

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  • 造影超音波による進行性膵癌の治療効果判定

    西田 睦, 小井戸 一光, 市村 健, 廣川 直樹, 中田 健生, 染谷 正則, 庄内 孝春, 山 直也, 兵頭 秀樹, 大谷 静治, 木村 幸子, 佐藤 昌明

    膵臓   18 ( 3 )   436 - 436   2003年6月

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    記述言語：日本語   出版者・発行元：日本膵臓学会  

    医中誌

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  • 【内視鏡医のための膵画像診断】超音波検査・造影超音波検査による膵疾患の診断

    小井戸 一光, 市村 健, 廣川 直樹, 山 直也, 晴山 雅人, 西田 睦, 佐藤 武史, 神山 直久, 嶺 喜隆, 矢野 雅彦

    消化器内視鏡   15 ( 5 )   651 - 659   2003年5月

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    記述言語：日本語   出版者・発行元：(株)東京医学社  

    膵疾患の画像診断においては超音波検査が第一選択である.距離分解能において超音波はEUS,IDUSに及ばないが,超音波検査もここ10数年の間に数々の開発が行われ,EUS,IDUSでは得られない情報が得られるようになった.Bモードにおいてはハーモニックイメージングにより膵内の小病変や膵管の軽度拡張が描出できるようになり,カラー/パワードプラで膵癌の脈管浸潤診断や血管性病変が診断可能となった.更に造影超音波の登場により,血流情報からのアプローチによって膵癌と腫瘤形成性膵炎の鑑別や,IPMTの微小乳頭状腫瘍の描出も可能となった.超音波は膵病変のスクリーニングにとどまらず,質的診断と病変のフォローに有用な検査法となったと言える

    医中誌

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  • 造影超音波による進行膵癌の化学放射線療法前後の治療効果判定

    市村 健, 小井戸 一光, 廣川 直樹, 西田 睦, 中田 健生, 染谷 正則, 庄内 孝春, 山 直也, 兵頭 秀樹

    超音波医学   30 ( Suppl. )   S296 - S296   2003年4月

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    記述言語：日本語   出版者・発行元：(公社)日本超音波医学会  

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  • 造影超音波による原発性肝癌門脈腫瘍栓の治療効果判定

    西田 睦, 小井戸 一光, 市村 健, 廣川 直樹, 中田 健生, 染谷 正則, 庄内 孝春, 山 直也, 兵頭 秀樹

    超音波医学   30 ( Suppl. )   S361 - S361   2003年4月

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    記述言語：日本語   出版者・発行元：(公社)日本超音波医学会  

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  • 造影超音波によって嚢胞壁在結節が明瞭となった膵IPMTの1例

    宇佐見 陽子, 小井戸 一光, 荒谷 和紀, 小島 一男, 高木 克, 廣川 直樹, 市村 健, 中田 健生, 庄内 孝春, 山 直也, 兵頭 秀樹, 西田 睦

    超音波医学   30 ( 2 )   J237 - J237   2003年3月

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    記述言語：日本語   出版者・発行元：(公社)日本超音波医学会  

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  • 造影超音波検査による進行膵管癌の化学放射線療法の治療効果判定

    西田 睦, 小井戸 一光, 市村 健, 廣川 直樹, 中田 健生, 染谷 正則, 庄内 孝春, 山 直也, 兵頭 秀樹, 晴山 雅人

    超音波医学   30 ( 2 )   J238 - J238   2003年3月

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    記述言語：日本語   出版者・発行元：(公社)日本超音波医学会  

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  • 3D造影超音波検査(3D-EU)を用いた肝腫瘍の非手術的治療効果判定

    市村 健, 小井戸 一光, 廣川 直樹, 中田 健生, 染谷 正則, 庄内 孝春, 山 直也, 兵頭 秀樹, 西田 睦

    超音波医学   30 ( 2 )   J236 - J237   2003年3月

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    記述言語：日本語   出版者・発行元：(公社)日本超音波医学会  

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  • Efficacy of SPIO-MR imaging in the diagnosis of liver metastases from colorectal carcinomas 査読

    T Furuhata, K Okita, T Tsuruma, F Hata, Y Kimura, T Katsuramaki, M Mukaiya, N Hirokawa, T Ichimura, N Yama, K Koito, K Sasaki, K Hirata

    DIGESTIVE SURGERY   20 ( 4 )   321 - 325   2003年

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    記述言語：英語   掲載種別：研究論文（学術雑誌）  

    DOI： 10.1159/000071758

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  • 3-D超音波が癌の進展度診断に有用であった,胆嚢管癌と膵癌の2例

    土本 正, 小井戸 一光, 市村 健, 廣川 直樹, 染谷 正則, 庄内 孝春, 山 直也, 兵頭 秀樹, 河合 有里子, 晴山 雅人

    超音波医学   29 ( 4 )   J401 - J401   2002年7月

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    記述言語：日本語   出版者・発行元：(公社)日本超音波医学会  

    医中誌

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  • 造影超音波検査による肝腫瘍の鑑別診断 CT,CTAとの対比

    小井戸 一光, 市村 健, 廣川 直樹, 土本 正, 染谷 正則, 庄内 孝春, 山 直也, 兵頭 秀樹, 河合 有里子, 晴山 雅人

    超音波医学   29 ( 4 )   J400 - J400   2002年7月

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    記述言語：日本語   出版者・発行元：(公社)日本超音波医学会  

    医中誌

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  • Dynamic flowを用いた肝腫瘍に対する非手術的治療の効果判定

    市村 健, 小井戸 一光, 廣川 直樹, 河合 有里子, 中田 健生, 庄内 孝春, 染谷 正則, 山 直也, 兵頭 秀樹, 佐藤 武史

    超音波医学   29 ( Suppl. )   S375 - S375   2002年5月

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    記述言語：日本語   出版者・発行元：(公社)日本超音波医学会  

    医中誌

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  • Brachial plexus: Normal anatomy and pathological conditions 査読

    Kazusa Hyodoh, Hideki Hyodoh, Hidenari Akiba, Mitsuharu Tamakawa, Noriko Nakamura, Naoya Yama, Takaharu Syonai, Tadashi Tsuchimoto, Hidechika Ohmoto, Masashi Ogasawara, Michio Banda, Makoto Furuse, Masato Hareyama

    Current Problems in Diagnostic Radiology   31 ( 5 )   179 - 188   2002年

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    記述言語：英語   掲載種別：研究論文（学術雑誌）   出版者・発行元：Mosby Inc.  

    DOI： 10.1067/mdr.2002.127636

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  • A case of hepatocellular carcinoma: The feasibility of intravenous contrast enhanced ultrasonography in evaluating percutaneous microwave coagulation therapy

    Naoki Hirokawa, Kazumitsu Koito, Sjsum, Kensei Nakata, Takeshi Ichimura, Masanori Someya, Takaharu Shounai, Naoya Yama, Hideki Hyoudou

    Journal of Medical Ultrasonics   29 ( 1 )   J17 - J21   2002年

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    記述言語：日本語   掲載種別：研究論文（学術雑誌）  

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  • Spiral CT venography of the lower extremities by injection via an arm vein in patients with leg swelling 査読

    S Yoshida, H Akiba, M Tamakawa, N Yama, M Takeda, M Hareyama

    BRITISH JOURNAL OF RADIOLOGY   74 ( 887 )   1013 - 1016   2001年11月

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    記述言語：英語   掲載種別：研究論文（学術雑誌）  

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  • Virtual CT cholangioscopy: Comparison with fiberoptic cholangioscopy 査読

    K Koito, T Namieno, N Hirokawa, T Ichimura, T Syonai, N Yama, M Mukaiya, K Hirata, K Sakata, M Hareyama

    ENDOSCOPY   33 ( 8 )   676 - 681   2001年8月

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    記述言語：英語   掲載種別：研究論文（学術雑誌）  

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  • Pancreas: imaging diagnosis with color/power Doppler ultrasonography, endoscopic ultrasonography, and intraductal ultrasonography 査読

    K Koito, T Namieno, T Nagakawa, N Hirokawa, T Ichimura, T Syonai, N Yama, M Someya, K Nakata, K Sakata, M Hareyama

    EUROPEAN JOURNAL OF RADIOLOGY   38 ( 2 )   94 - 104   2001年5月

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    記述言語：英語   掲載種別：研究論文（学術雑誌）  

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  • The spectrum of findings in supra-aortic Takayasu's arteritis as seen on spiral CT angiography and digital subtraction angiography 査読

    S Yoshida, H Akiba, M Tamakawa, N Yama, M Takeda, M Hareyama, T Nakata, K Shimamoto

    CARDIOVASCULAR AND INTERVENTIONAL RADIOLOGY   24 ( 2 )   117 - 121   2001年3月

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    記述言語：英語   掲載種別：研究論文（学術雑誌）  

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  • Usefulness of magnetic resonance imaging for surgical management of extravasation of an antitumor agent: a case report 査読

    N Yama, Y Tsuchida, S Nuka, S Kitagawa, J Saito, H Hyodoh, K Hyodoh, K Koito, M Tamakawa, H Akiba, M Hareyama, Y Asai

    JAPANESE JOURNAL OF CLINICAL ONCOLOGY   31 ( 3 )   122 - 124   2001年3月

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    記述言語：英語   掲載種別：研究論文（学術雑誌）  

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  • CT arteriography-guided embolization in hepatic bleeding: A case report 査読

    N. Yama, S. Kitagawa, J. Saito, H. Inomata, K. Koito, M. Tamakawa, H. Akiba, M. Hareyama, Y. Asai

    Emergency Radiology   8 ( 1 )   55 - 58   2001年

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    記述言語：英語   掲載種別：研究論文（学術雑誌）   出版者・発行元：Springer New York  

    DOI： 10.1007/PL00011872

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  • Spontaneously reduced midgut malrotation: CT diagnosis 査読

    N Yama, H Akiba, M Tamakawa, A Oouchi, K Sakata, K Koito, M Hareyama, K Morita

    ABDOMINAL IMAGING   25 ( 2 )   132 - 133   2000年3月

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    記述言語：英語   掲載種別：研究論文（学術雑誌）  

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  • Acquired anomalous intrapulmonary venous connection secondary to pulmonary venous stenosis 査読

    S Yoshida, H Akiba, M Tamakawa, M Takeda, N Yama, M Hareyama, N Takagi, S Kikuchi, T Abe

    BRITISH JOURNAL OF RADIOLOGY   73 ( 866 )   211 - 213   2000年2月

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    記述言語：英語   掲載種別：研究論文（学術雑誌）  

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  • Anomalous vessels in the middle ear associated with congenital anomalies of the internal carotid artery 査読

    T Himi, H Akiba, N Yama, M Sakata, A Kataura

    ORL-JOURNAL FOR OTO-RHINO-LARYNGOLOGY AND ITS RELATED SPECIALTIES   61 ( 4 )   219 - 223   1999年7月

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    記述言語：英語   掲載種別：研究論文（学術雑誌）  

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  • Pseudoaneurysm of the superficial femoral artery in Behcet's disease with spontaneous thrombosis followed by CT angiography 査読

    S Yoshida, H Akiba, M Tamakawa, M Takeda, N Yama, M Hareyama, K Morita, A Masuda, K Shimamoto

    CARDIOVASCULAR AND INTERVENTIONAL RADIOLOGY   21 ( 4 )   342 - 344   1998年7月

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    記述言語：英語   掲載種別：研究論文（学術雑誌）  

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  • Mucin-producing pancreatic tumors: Comparison of MR cholangiopancreatography with endoscopic retrograde cholangiopancreatography 査読

    K Koito, T Namieno, T Ichimura, N Yama, M Hareyama, K Morita, M Nishi

    RADIOLOGY   208 ( 1 )   231 - 237   1998年7月

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    記述言語：英語   掲載種別：研究論文（学術雑誌）  

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  • Long survival of patients with unresectable cervical carcinoma after radiotherapy 査読

    K Sakata, M Hareyama, N Yama, A Oouchi, M Shido, H Nagakura, K Morita, R Kudo

    JAPANESE JOURNAL OF CLINICAL ONCOLOGY   27 ( 4 )   285 - 287   1997年8月

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    記述言語：英語   掲載種別：研究論文（学術雑誌）  

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▼全件表示

MISC

  • Epithelioid Sarcomaの画像

    土屋 高旭, 玉川 光春, 河合 有里子, 荒谷 和紀, 兵藤 秀樹, 山 直也, 庄内 孝春, 佐藤 大志, 小野寺 麻希, 鷲尾 嘉一, 浅井 真友美, 畠中 正光

    Japanese Journal of Radiology   32 ( Suppl. )   3 - 3   2014年2月

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    記述言語：日本語   出版者・発行元：(公社)日本医学放射線学会  

    医中誌

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  • 画像診断 (特集 日本版敗血症診療ガイドラインを読み解く)

    池田 寿昭, 鈴木 泰, 山 直也

    ICUとCCU = Japanese journal of intensive care medicine : 集中治療医学   36 ( 11 )   987 - 990   2012年11月

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    記述言語：日本語   出版者・発行元：医学図書出版  

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  • 再燃した肺胞出血に対し血漿交換療法が著効したChurg-Strauss syndromeの一例

    吉田 真一郎, 田辺 美幸, 升田 好樹, 今泉 均, 山 直也, 巽 博臣, 後藤 京子, 浅井 康文

    日本集中治療医学会雑誌   19 ( 4 )   623 - 627   2012年

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    記述言語：日本語   出版者・発行元：一般社団法人 日本集中治療医学会  

    肺胞出血を合併したChurg-Strauss syndrome（CSS）の一例を経験した。本症例は，肺胞出血に伴う呼吸不全に，播種性血管内凝固症候群，脳内出血を合併していた。ステロイドパルス療法で一旦改善した肺胞出血が再燃したため，血漿交換療法を行ったところ急速に改善し，救命することができた。ステロイド抵抗性CSSの治療として，免疫抑制薬の使用が推奨されているが，臓器障害を合併する重症CSSの死因はほとんどが感染症の合併によるものである。本症例から，重症CSS治療では，感染症の発症および悪化を招く可能性がある免疫抑制療法以外の治療法として，病態形成に関与する炎症性メディエータ除去の有用性が示唆され，血漿交換療法は有効な治療法となり得ると考えられた。

    DOI： 10.3918/jsicm.19.623

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  • トレーサー量のI-131水溶液の蒸発による放射能の変化の検討

    山 直也, 坂田 耕一, 晴山 雅人

    放射線防護医療   ( 7 )   34 - 36   2011年12月

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    記述言語：日本語   出版者・発行元：放射線防護医療研究会  

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  • 甲状腺摘出患者のI-131治療後の体外線量における経時的推移の検討

    山 直也, 浅沼 治, 佐藤 香織

    放射線防護医療   ( 6 )   34 - 36   2010年12月

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    記述言語：日本語   出版者・発行元：放射線防護医療研究会  

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  • 甲状腺摘出患者のI-131内用療法後の体外線量と全身分布の経時的推移の検討

    山 直也, 浅沼 治, 佐藤 香織

    放射線防護医療   ( 5 )   29 - 31   2009年12月

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    記述言語：日本語   出版者・発行元：放射線防護医療研究会  

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  • 放射線によって生じる火災報知器の誤作動の検討

    山 直也, 晴山 雅人

    放射線防護医療   ( 4 )   37 - 39   2008年12月

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    記述言語：日本語   出版者・発行元：放射線防護医療研究会  

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  • 胸部大血管損傷 (特集 救急単純X線診断--胸腹部急性疾患を中心に) -- (疾患別--外因性疾患)

    山 直也, 晴山 雅人, 浅井 康文

    救急医学   32 ( 13 )   1853 - 1856   2008年12月

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    記述言語：日本語   出版者・発行元：へるす出版  

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  • 救命救急センターにおける胸部大動脈ステントグラフトの役割

    栗本 義彦, 浅井 康文, 長谷 守, 奈良 理, 森 和久, 山 直也, 伊藤 寿朗, 馬場 俊雄, 川原田 修義, 樋上 哲哉

    脈管学 : 日本脈管学会機関誌 : the journal of Japanese College of Angiology   48 ( 3 )   283 - 292   2008年6月

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    記述言語：日本語  

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  • 肝エキノコッカス症の造影超音波所見の検討

    齊藤 正人, 廣川 直樹, 佐藤 大志, 河合 有里子, 笠原 理子, 山 直也, 晴山 雅人, 西田 睦, 小井戸 一光

    Japanese journal of medical ultrasonics = 超音波医学   35   S452   2008年4月

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    記述言語：日本語  

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  • T1, T2膵癌の体外式超音波 : CT, EUSとの対比

    廣川 直樹, 斉藤 正人, 小井戸 一光, 佐藤 大志, 河合 有里子, 笠原 理子, 山 直也, 晴山 雅人

    Japanese journal of medical ultrasonics = 超音波医学   35   S373   2008年4月

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    記述言語：日本語  

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  • 巻頭インタビュー 北海道の地域医療に貢献する 札幌医科大学付属病院院長 塚本泰司先生 放射線医学講座 山直也先生に聞く

    塚本 泰司, 山 直也, 寺田

    PET journal   ( 4 )   4 - 6   2008年

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    記述言語：日本語   出版者・発行元：寺田国際事務所先端医療技術研究所  

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  • 循環器疾患(3)胸部・腹部大動脈瘤 (特集 胸腹部画像診断の進め方) -- (胸腹部内因性疾患)

    山 直也, 栗本 義彦, 晴山 雅人

    救急医学   31 ( 4 )   387 - 391   2007年4月

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    記述言語：日本語   出版者・発行元：へるす出版  

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  • A case of spinal epidural and pelvic abscess with the rectal perforation

    Hiroaki Shima, Eiri Ezoe, Osamu Nara, Koji Hashimoto, Reiko Kyan, Masato Isobe, Tomohisa Furuhata, Naoya Yama, Yasufumi Asai, Koichi Hirata

    Japanese Journal of Gastroenterological Surgery   40 ( 5 )   665 - 670   2007年

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    記述言語：日本語   出版者・発行元：Japanese Society of Gastroenterological Surgery  

    DOI： 10.5833/jjgs.40.665

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  • 直腸穿通により骨盤内膿瘍および脊椎硬膜外膿瘍を来した1例

    島 宏彰, 江副 英理, 奈良 理, 橋本 功二, 喜屋武 玲子, 磯部 将人, 古畑 智久, 山 直也, 浅井 康文, 平田 公一

    日本消化器外科学会雑誌   40 ( 5 )   665 - 670   2007年

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    記述言語：日本語   出版者・発行元：一般社団法人日本消化器外科学会  

    DOI： 10.5833/jjgs.40.665

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  • 遠隔地域からのEメールを用いた画像伝送ならびに救急車からの救急現場画像伝送システムについて

    江副 英理, 伊藤 靖, 山 直也, 島 宏彰, 平田 公一, 浅井 康文

    日本腹部救急医学会雑誌 = Journal of abdominal emergency medicine   26 ( 5 )   611 - 616   2006年7月

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    記述言語：日本語  

    DOI： 10.11231/jaem1993.26.611

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  • 肝損傷を契機とした重症肝機能障害3症例における^<99m>Tc-GSA肝シンチグラフィを用いた肝機能予後の検討

    磯部 将人, 江副 英理, 山 直也, 和田 武志, 栗本 義彦, 升田 好樹, 今泉 均, 浅井 康文

    日本外傷学会雑誌 = Journal of the Japanese Association for the Surgery of Trauma   20 ( 3 )   272 - 277   2006年7月

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    記述言語：日本語  

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  • 診断が困難な消化管出血症例に対する新たな出血源同定の試み

    木村 康利, 山 直也, 磯部 将人, 信岡 隆幸, 古畑 智久, 浅井 康史, 晴山 雅人, 平田 公一

    日本腹部救急医学会雑誌 = Journal of abdominal emergency medicine   26 ( 3 )   387 - 389   2006年3月

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    記述言語：日本語  

    DOI： 10.11231/jaem1993.26.387

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  • Abdominal Emergency Medicine and Information System-Transporting a Patient by Image Transmission Using E-mail from a Remote Area and as Telemedicine Image Transmission Using Digital Cellular Phone from Ambulance-

    江副 英理, 伊藤 靖, 山 直也, 島 宏彰, 平田 公一, 浅井 康文

    日本腹部救急医学会雑誌   26 ( 5 )   611 - 616   2006年

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    記述言語：日本語   出版者・発行元：日本腹部救急医学会  

    It is important to link up with distant health communityies in emergency medicine. We decided to transport a patient with an epidural abscess from a remote area by image transmission using E-mail. E-mail is independent of time and area. We established mobile telemedicine via image transmission using digital cellular phone from an ambulance. This is useful for prediction of patient status.

    DOI： 10.11231/jaem1993.26.611

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  • A Novel Method for the Detection and the Localization of Intestinal Bleeding Using a Fusion Image of Tc-99m-labeled RBC SPECT and X-ray CT

    木村 康利, 山 直也, 磯部 将人, 信岡 隆幸, 古畑 智久, 浅井 康史, 晴山 雅人, 平田 公一

    日本腹部救急医学会雑誌   26 ( 3 )   387 - 389   2006年

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    記述言語：日本語   出版者・発行元：日本腹部救急医学会  

    Although Tc-99m-labeled RBC SPECT is sensitive for detection of intestinal bleeding, it cannot provide a highdegree of specific anatomic information. We introduced a novel method which facilitates the detection and the localizationof intestinal bleeding using a fusion image of Tc-99m-Labeled RBC SPECT and X-ray CT. The fused image iscomposed of those from Tc-99m-labeled RBC SPECT and from x-ray CT and able to reveal small intestinal bleedingwith specific anatomic information. We believe that the fused image is useful for anatomic localization of gastrointestinalbleeding and helpful for surgical intervention.

    DOI： 10.11231/jaem1993.26.387

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  • 造影超音波による化学放射線療法の治療効果判定に関する検討

    佐藤 大志, 小井戸 一光, 西田 睦, 廣川 直樹, 河合 有里子, 染谷 正則, 庄内 孝春, 山 直也, 兵頭 秀樹

    Japanese journal of medical ultrasonics = 超音波医学   32 ( Suppl. )   S179 - S179   2005年4月

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    記述言語：日本語   出版者・発行元：(公社)日本超音波医学会  

    医中誌

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  • DD-723を用いた造影超音波による肝腫瘍の存在診断能の検討

    西田 睦, 小井戸 一光, 廣川 直樹, 佐藤 大志, 河合 有里子, 染谷 正則, 庄内 孝春, 山 直也, 兵頭 秀樹, 晴山 雅人

    Japanese journal of medical ultrasonics = 超音波医学   32 ( Suppl. )   S192 - S192   2005年4月

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    記述言語：日本語   出版者・発行元：(公社)日本超音波医学会  

    医中誌

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  • 集束超音波によるラット肝癌の治療効果およびアポトーシスの検討

    廣川 直樹, 小井戸 一光, 西田 睦, 佐藤 大志, 河合 有里子, 染谷 正則, 庄内 孝春, 山 直也, 兵頭 秀樹, 工藤 信樹, 山本 克之, 晴山 雅人

    Japanese journal of medical ultrasonics = 超音波医学   32 ( Suppl. )   S242 - S242   2005年4月

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    記述言語：日本語   出版者・発行元：(公社)日本超音波医学会  

    医中誌

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  • 造影超音波による化学放射線療法の治療効果判定に関する検討

    佐藤 大志, 小井戸 一光, 西田 睦, 廣川 直樹, 河合 有里子, 染谷 正則, 庄内 孝春, 山 直也, 兵頭 秀樹

    Journal of medical ultrasonics = 超音波医学   32 ( Suppl. )   S179 - S179   2005年4月

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    記述言語：日本語   出版者・発行元：(公社)日本超音波医学会  

    医中誌

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  • DD-723を用いた造影超音波による肝腫瘍の存在診断能の検討

    西田 睦, 小井戸 一光, 廣川 直樹, 佐藤 大志, 河合 有里子, 染谷 正則, 庄内 孝春, 山 直也, 兵頭 秀樹, 晴山 雅人

    Journal of medical ultrasonics = 超音波医学   32 ( Suppl. )   S192 - S192   2005年4月

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    記述言語：日本語   出版者・発行元：(公社)日本超音波医学会  

    医中誌

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  • 集束超音波によるラット肝癌の治療効果およびアポトーシスの検討

    廣川 直樹, 小井戸 一光, 西田 睦, 佐藤 大志, 河合 有里子, 染谷 正則, 庄内 孝春, 山 直也, 兵頭 秀樹, 工藤 信樹, 山本 克之, 晴山 雅人

    Journal of medical ultrasonics = 超音波医学   32 ( Suppl. )   S242 - S242   2005年4月

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    記述言語：日本語   出版者・発行元：(公社)日本超音波医学会  

    医中誌

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  • 頸部リンパ節微細血管描出のための新しい造影US法

    西田 睦, 小井戸 一光, 市村 健, 廣川 直樹, 河合 有里子, 染谷 正則, 庄内 孝春, 中田 健生, 山 直也, 神山 直久

    Journal of medical ultrasonics = 超音波医学   31 ( 5 )   J347 - J353   2004年9月

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    記述言語：日本語   出版者・発行元：(公社)日本超音波医学会  

    医中誌

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  • 頚部リンパ節微細血管構築描出のための新しい造影エコー法

    西田 睦, 小井戸 一光, 市村 健, 廣川 直樹, 河合 有里子, 染谷 正則, 庄内 孝春, 中田 健生, 山 直也, 兵頭 秀樹, 晴山 雅人, 中屋 重光, 神山 直久

    Journal of medical ultrasonics = 超音波医学   31 ( Suppl. )   S96 - S96   2004年4月

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    記述言語：日本語   出版者・発行元：(公社)日本超音波医学会  

    医中誌

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  • Value of fast dynamic contrast-enhanced MRI with endorectal coil in patients with elevated PSA levels after radical prostatectomy

    M Takeda, M Tamakawa, H Akiba, M Hareyama, H Hyodo, K Hyodo, N Yama, T Shonai

    AMERICAN JOURNAL OF ROENTGENOLOGY   182 ( 4 )   118 - 118   2004年

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    記述言語：英語   掲載種別：研究発表ペーパー・要旨（国際会議）  

    Web of Science

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  • 胸部X線,胸部CT,MRI,心臓核医学検査 (特集 胸部外傷--診断・治療の進歩) -- (各種診断法の有用性と限界)

    山 直也, 晴山 雅人, 浅井 康文

    救急医学   26 ( 12 )   1684 - 1691   2002年11月

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    記述言語：日本語   出版者・発行元：へるす出版  

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  • 経静脈性造影超音波が肝癌の経皮的マイクロウェーブ凝固療法の治療効果判定に有用であった1例

    廣川 直樹, 小井戸 一光, 中田 健生, 市村 健, 染谷 正則, 庄内 孝春, 山 直也, 兵頭 秀樹

    Journal of medical ultrasonics = 超音波医学   29 ( 1 )   J17 - J21   2002年1月

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    記述言語：日本語   出版者・発行元：(公社)日本超音波医学会  

    80歳女.C型肝硬変として加療中に超音波検査により肝内腫瘤が認められた.造影CTにより腫瘤は原発性肝癌が疑われた.超音波ガイド下針生検により高分化型肝癌と診断され,患者が高齢者であることと単発腫瘍であることから,マイクロウェーブ凝固療法(PMCT)を施行した.その後の経過観察に経静脈性超音波を行ったところ,造影CTと同様に結節内に造影効果は認められず,治療後6ヵ月後の造影CTでも同様に結果を得,腫瘍結節は完全壊死と判断された.経静脈性超音波検査は造影CTと同様に治癒判定に有用であったと考えられた

    医中誌

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  • Segmental analysis of cochlea on three-dimensional MR imaging and high-resolution CT

    H Akiba, M Tamakawa, H Hyodoh, K Hyodoh, N Nakamura, N Yama

    RADIOLOGY   221   135 - 135   2001年11月

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    記述言語：英語   掲載種別：研究発表ペーパー・要旨（国際会議）  

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  • Feasibility evaluation of new Tc-99m-GSA index to estimate liver function with a short-term acquisition

    K Fujimori, N Yama, M Takeda, M Hareyama

    EUROPEAN JOURNAL OF NUCLEAR MEDICINE   28 ( 8 )   1087 - 1087   2001年8月

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    記述言語：英語   掲載種別：研究発表ペーパー・要旨（国際会議）  

    Web of Science

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  • Tc-99m-galactosyl human serum albumin (Tc-99m-GSA) early-phase index - Is it possible to estimate liver function with a short-term acquisition?

    K Fujimori, T Satoh, N Yama, M Hareyama

    JOURNAL OF NUCLEAR MEDICINE   42 ( 5 )   328P - 328P   2001年5月

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    記述言語：英語   掲載種別：研究発表ペーパー・要旨（国際会議）  

    Web of Science

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  • Early brain CAT findings are useful to predict neurological outcome after cardiac arrest

    Y Takeyama, K Mori, Y Itoh, S Nara, M Yoshida, Y Asai, N Yama

    CRITICAL CARE MEDICINE   28 ( 12 )   A166 - A166   2000年12月

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    記述言語：英語   掲載種別：研究発表ペーパー・要旨（国際会議）  

    Web of Science

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  • Multi-sectional fast dynamic contrast-enhanced MR imaging of head and neck malignant neoplasms

    H Akiba, M Tamakawa, S Yoshida, M Takeda, N Yama, M Hareyama

    RADIOLOGY   217   177 - 178   2000年11月

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    記述言語：英語   掲載種別：研究発表ペーパー・要旨（国際会議）  

    Web of Science

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  • Segmental decreased uptake of Tc-99m-labeled galactosyl-neoglycoalbumin in nontumorous liver tissue: Sensitivity analysis of the factors influencing liver uptake with non-linear compartment model.

    K Fujimori, K Ichimura, N Hirokawa, N Yama, S Yoshida, M Takeda, T Shounai, K Koito, M Hareyama

    JOURNAL OF NUCLEAR MEDICINE   41 ( 5 )   319P - 319P   2000年5月

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    記述言語：英語   掲載種別：研究発表ペーパー・要旨（国際会議）  

    Web of Science

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  • Mucin-producing pancreatic tumors: comparison of MR cholangiopancreatography with endoscopic retrograde cholangiopancreatography

    K Koito, T Namieno, T Ichimura, N Yama, M Hareyama, K Morita, M Nishi

    GASTROINTESTINAL ENDOSCOPY   50 ( 4 )   591 - 592   1999年10月

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    記述言語：英語  

    Web of Science

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  • 非線形3コンパートメントモデルによる ^<99m>Tc-GSA 受容体量の推定 : 採血を要さない受容体結合型モデル

    藤森 研司, 庄内 孝春, 小井戸 一光, 吉田 悟, 武田 美貴, 山 直也, 桂巻 正, 古畑 智久, 平田 公一, 晴山 雅人

    核医学   36 ( 7 )   753 - 760   1999年9月

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    記述言語：日本語  

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  • 子宮頸部癌における高線量率と低線量率腔内照射の線量率効果比に関する検討

    晴山 雅人, 大内 敦, 志藤 光男, 武田 美貴, 山 直也, 坂田 耕一, 森田 和夫

    日本放射線腫瘍学会誌学術大会報文集   17 ( 1 )   143 - 143   1995年10月

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    記述言語：日本語  

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共同研究・競争的資金等の研究課題

  • 子宮内膜がんのリンパ節転移と関連するMRI画像特徴量同定

    研究課題/領域番号：23K07209  2023年4月 - 2026年3月

    日本学術振興会  科学研究費助成事業  基盤研究(C)

    畠中 正光, 山 直也, 斉藤 豪

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    配分額：4680000円 （ 直接経費：3600000円 、 間接経費：1080000円 ）

    子宮内膜病変を有することが手術で確認され、術前に骨盤部MRI検査が施行された109症例のtexture featureを抽出し、以下の臨床指標との関連を統計学的に解析した。申請時にも大まかな解析を行っていたが、texture解析時のdata processingの問題が生じたために全てのデータを再度解析しなおしたところ以下の結果を得た。
    子宮内膜病変の良悪鑑別に関しては、ADCmapの25%値(AUC=0.924)・ADCmapの50%値および平均値(ともにAUC=0.914)が非常に高い鑑別能を有することが分かった。Type1 vs.2の鑑別に関しては、AUC≧0.8を示すparameterは存在しなかったが、T2WIのGLRM SRE(AUC=0.791)、GLRLM LRHGE(AUC=0.783)が比較的高い鑑別能を有することが分かった。筋層浸潤能に関するT1a vs. 1bの鑑別に関しては、ADCmapから抽出したいくつかのparameterでAUC≧0.7を示すものはあったが≧0.75を示すものはなかった。
    リンパ節転移に関しては、T2WIのGLCM Energy(AUC=0.813)・GLCM Entropy(AUC=0.780)が比較的高い鑑別能を示した。リンパ節短径10mm以上ではリンパ節転移を示すと考えられるので、短径10mm以上の症例を除いて解析すると、T2WIのGLCM Energy(AUC=0.741)・GLCM Entropy(AUC=0.701)ともに鑑別能はやや低下した。逆に、DWI(b=1000s/mm2)のGLCM Contrast(AUC=0.803)・GLCM Correlation(AUC=0.806)、ADCmapのGLZLM SZE(AUC=0.826)、GLZLM SZHGE(AUC=0.831)は比較的高い鑑別能を示した。これらのparameterは短径10mm以上のリンパ節を含む場合よりも鑑別能は高くなっており、臨床的に非常に有用であると考えられるがデータの再現性も十分検証して結論する必要がある。

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  • MR画像から計算したconductivity値に基づく直腸がん悪性度評価法確立

    研究課題/領域番号：18K07635  2018年4月 - 2023年3月

    日本学術振興会  科学研究費助成事業  基盤研究(C)

    畠中 正光, 山 直也, 小野寺 麻希, 杉田 真太朗, 西舘 敏彦

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    配分額：4290000円 （ 直接経費：3300000円 、 間接経費：990000円 ）

    ドイツの共同研究者であるUlrich博士との連携が十分ではなく、現在のところ解析が可能であった10例のconductivity imagesに対して、LIFEx Version7.0を用い、Gray level=64、データ範囲±3δの設定条件で行ったtexture解析結果からは以下の結果が示された。
    リンパ節転移巣の有無に関して、Gray-Level Co-Occurence Matrix Contrast： p=0.006、Gray-Level Co-Occurence Matrix Correlation : p=0.027、病変の進行度に関して（Stage 1,2 versus Stage 3,4）も同様にGray-Level Co-Occurence Matrix Contrast： p=0.006、Gray-Level Co-Occurence Matrix Correlation : p=0.027、 また有意とは言えなかったが、病変分化度（Well differentiated adenocarcinoma versus Moderate differentiated adenocarcinoma）に関してGray Level Run Length High Gray Level Run Emphasis: p=0.086、リンパ節転移の有無に関して、最大値：p=0.093、25％値：p=0.093、同様に病変の進行度に関して（Stage 1,2 versus Stage 3,4）、最大値：p=0.093、25％値：p=0.093の結果が得られ解析症例数が増加すると、特にリンパ節転移の有無に関してある程度予測可能となることが期待された。

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  • PC-cineMRIによる肺高血圧症の早期発見と治療効果判定法の確立

    研究課題/領域番号：16K10323  2016年4月 - 2019年3月

    日本学術振興会  科学研究費助成事業  基盤研究(C)

    村山 貞之, 山 直也, 畠中 正光, 岩澤 多恵, 土屋 奈々絵

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    配分額：4550000円 （ 直接経費：3500000円 、 間接経費：1050000円 ）

    本研究の目的は肺高血圧症の予後評価に非侵襲的な検査法であるフェーズコントラストＭＲＩ（ＰＣ－ＭＲＩ）が有用であるかを検討することであった。ＰＣ－ＭＲＩで測定した右心拍出量低下は間質性肺炎に関連した肺高血圧症の予後不良に関連することが判明した。右心機能の評価は心臓ＭＲＩで行うのがゴールドスタンダードとなっているが，肺高血圧症により右心に大きな負荷がかかると，右心系は著明に拡大し，心臓ＭＲＩでの解析は煩雑になる。一方ＰＣ－ＭＲＩによる肺血流評価は疾患により肺動脈が拡張しても，解析が容易で，安定した結果が得られるので，優れた予後評価指標になりうると考えられる。

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  • IVIMイメージングによる化学放射線治療効果・予後予測法確立

    研究課題/領域番号：26461831  2014年4月 - 2017年3月

    日本学術振興会  科学研究費助成事業  基盤研究(C)

    畠中 正光, 玉川 光春, 河合 有里子, 荒谷 和紀, 中田 健生, 黒瀬 誠, 中村 和正, 吉浦 敬, 山 直也

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    配分額：4550000円 （ 直接経費：3500000円 、 間接経費：1050000円 ）

    28例の登録を行ったが画質不良や臨床データ不足のため十分な解析が行えたのは10例であった。再発が認められなかった6例の治療前D値は0.640±0.168 mm2/s、再発が認められた4例の治療前D値は0.921±0.204 mm2/sであり両者に有意差(p<0.05)を認めた。治療開始後早期(10Gy)時点でのD値の上昇率((D10Gy/Dpre)-1)は、再発無し群では0.350±0.533に対し、再発群では-0.04±0.174と値に差はあったが統計学上有意差は認められなかった(p=0.28)。IVIMイメージングから計算されるFおよびD*はデータのバラツキが大きく解析は行わなかった。

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  • 肝修復・肝再生における肝組織幹細胞の臨床的・基礎的役割に関する基盤的研究

    研究課題/領域番号：22390259  2010年 - 2012年

    文部科学省  科学研究費補助金(基盤研究(B))  基盤研究(B)

    平田 公一, 三高 俊広, 水口 徹, 中村 幸雄, 目黒 誠, 川本 雅樹, 山 直也, 巽 博臣, 太田 盛道, 今村 将史, 山口 洋志, 小島 隆, 澤田 典均

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    担当区分：連携研究者  資金種別：競争的資金

    配分額：19240000円 （ 直接経費：14800000円 、 間接経費：4440000円 ）

    以下の基礎的研究、臨床的研究の成果を得られた。【研究1】NASH関連肝硬変に対する2/3肝切除を急性肝不全モデル(CDAA授与モデル)に対し行ない、そこに肝細胞移植(HT)の効果を検討したところ、術前HTによる急性肝不全防止効果が証明された。【研究2】肝切除前後の周術期肝機能評価について、GSAを用いたABC曲線が構成する結果の統計学的処理を、慢性肝炎(CH)、肝硬変(LC)等を合併した肝切除例についてその有用性をAUCにより比較検討したところGSAのHH15とLHL15の双方因子について有用性が示唆され、ABCの優秀性が伺われ、ABCは新規機能評価因子と考えられた。

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