Updated on 2025/09/03

写真a

 
ICHISE Nobutoshi
 
Organization
School of Medicine Department of Physiology Lecturer
Title
Lecturer
External link

Degree

  • 博士（地球環境科学） ( 北海道大学 )

Research Interests

  • サルコメア

  • 発生

  • 興奮収縮連関

  • 心臓原基

  • 筋肉生理学

Research Areas

  • Life Science / Physiology

Education

  • Hokkaido University   Graduate School of Environmental Earth Science

    1996 - 2003

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  • Hokkaido University   School of Fisheries Sciences

    1991 - 1995

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Professional Memberships

Committee Memberships

  •   Review Editor, Frontiers in Cardiovascular Medicine  

    2024.9   

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    Committee type：Other

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  • 日本生理学会   評議員  

    2015   

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    Committee type：Academic society

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  • 第９３回日本生理学会大会   事務局長  

    2014.4 - 2016.3   

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    Committee type：Academic society

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  • 産学官連携の「質」の向上方策に関する調査委員会   委員  

    2008.4 - 2009.3   

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    Committee type：Academic society

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Papers

  • Plasma hepcidin level is elevated by water immersion-induced central fatigue via hepatic inflammatory response in male and female rats. Reviewed International journal

    Takuro Karaushi, Toshifumi Ogawa, Hiroyori Fusagawa, Taiki Kudo, Yuito Inoue, Takashi Yamada, Nobutoshi Ichise, Tatsuya Sato, Noritsugu Tohse

    Physiological reports   13 ( 15 )   e70468   2025.8

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    Fatigue is a subjective phenomenon caused by physical or mental overexertion; however, its objective biomarkers specific to the types of fatigue remain unclear. Here, we examined whether plasma hepcidin levels, which are regulated by inflammation or iron metabolism, are elevated by peripheral and central fatigue in male and female rats. Eight-week-old Wistar rats were divided into three groups: peripheral fatigue, central fatigue, and sedentary control groups. Peripheral fatigue was induced by moderate-intensity aerobic treadmill running, and central fatigue was induced by keeping rats in a cage flooded with water to a 2.5 cm depth for 5 days. Although both male and female rats showed similar behavioral phenotypes in peripheral and central fatigue groups, plasma hepcidin levels after fatigue induction were significantly elevated only in the central fatigue group. While neither iron panels nor tissue non-heme iron levels corresponded to changes in plasma hepcidin, levels of phospho-STAT3 at Tyr(705) in the liver were significantly elevated in both sexes in the central fatigue group, suggesting the presence of hepatic inflammation that can lead to hepcidin upregulation. The collective findings indicate that elevation of plasma hepcidin level may be a promising biomarker for central fatigue, but not for peripheral fatigue, regardless of iron metabolism alteration.

    DOI： 10.14814/phy2.70468

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  • Mapping research trends in obsessive-compulsive disorder before and after the COVID-19 pandemic: a bibliometric analysis focusing on its molecular mechanisms Reviewed

    Yuito Inoue, Nobutoshi Ichise, Wataru Ukai, Jun Shinozaki, Toshifumi Ogawa, Takuro Karaushi, Marenao Tanaka, Yukinori Akiyama, Masato Furuhashi, Atsushi Kuno, Tatsuya Sato

    Frontiers in Psychiatry   16   2025.6

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    DOI： 10.3389/fpsyt.2025.1615497

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  • Platelet-rich plasma does not accelerate the healing of damaged muscle following muscle strain. Reviewed International journal

    Hiroyori Fusagawa, Takashi Yamada, Tatsuya Sato, Yuki Ashida, Atsushi Teramoto, Hiroyuki Takashima, Azuma Naito, Nao Tokuda, Nao Yamauchi, Nobutoshi Ichise, Izaya Ogon, Toshihiko Yamashita, Noritsugu Tohse

    Journal of orthopaedic research : official publication of the Orthopaedic Research Society   2024.1

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    Although platelet-rich plasma (PRP) has been widely used regardless of the severity of muscle strain, there have been very few basic studies in which its effects on muscle injury were examined by using models that accurately mimic the clinical muscle strain injury process. Therefore, the aim of this study was to confirm by physiological and structural analyses whether PRP purified by a general preparation method has a muscle healing effect on muscle damage caused by eccentric contraction (ECC). Male Wistar rats were subjected to muscle injury induced by ECC in bilateral plantar flexor muscles using electrical stimulation and an automatically dorsiflexing footplate. The rats were randomly assigned to three groups by type of injection: phosphate-buffered saline (PBS), leukocyte-poor PRP (LP-PRP), or leukocyte-rich PRP (LR-PRP) injection into gastrocnemius muscles three times at weekly intervals. The platelet concentrations of the LP-PRP and LR-PRP were three to five times higher than that of whole blood. The recovery process of torque strength in the plantar flexor muscle, signal changes in MRI images, and histological evaluation 3 weeks after injury showed no obvious differences among the three groups, and every muscle recovered well from the injury without marked fibrosis. The results that neither LP-PRP nor LR-PRP was found to accelerate healing of muscle injuries suggested that conventional preparation and use of PRP for simple muscle injuries caused by muscle strain should be carefully considered, and further basic research using models that accurately mimic clinical practice should be carried out to determine the optimal use of PRP.

    DOI： 10.1002/jor.25784

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  • High-intensity interval training using electrical stimulation ameliorates muscle fatigue in chronic kidney disease-related cachexia by restoring mitochondrial respiratory dysfunction. Reviewed International journal

    Hiroyori Fusagawa, Tatsuya Sato, Takashi Yamada, Azuma Naito, Nao Tokuda, Nao Yamauchi, Nobutoshi Ichise, Toshifumi Ogawa, Takuro Karaushi, Atsushi Teramoto, Noritsugu Tohse

    Frontiers in physiology   15   1423504 - 1423504   2024

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    BACKGROUND: Exercise, especially high-intensity interval training (HIIT), can increase mitochondrial respiratory capacity and enhance muscular endurance, but its systemic burden makes it difficult to safely and continuously prescribe for patients with chronic kidney disease (CKD)-related cachexia who are in poor general condition. In this study, we examined whether HIIT using electrical stimulation (ES), which does not require whole-body exercise, improves muscle endurance in the skeletal muscle of 5/6 nephrectomized rats, a widely used animal model for CKD-related cachexia. METHODS: Male Wistar rats (10 weeks old) were randomly assigned to a group of sham-operated (Sham) rats and a group of 5/6 nephrectomy (Nx) rats. HIIT was performed on plantar flexor muscles in vivo with supramaximal ES every other day for 4 weeks to assess muscle endurance, myosin heavy-chain isoforms, and mitochondrial respiratory function in Nx rats. A single session was also performed to identify upstream signaling pathways altered by HIIT using ES. RESULTS: In the non-trained plantar flexor muscles from Nx rats, the muscle endurance was significantly lower than that in plantar flexor muscles from Sham rats. The proportion of myosin heavy chain IIa/x, mitochondrial content, mitochondrial respiratory capacity, and formation of mitochondrial respiratory supercomplexes in the plantaris muscle were also significantly decreased in the non-trained plantar flexor muscles from Nx rats than compared to those in plantar flexor muscles from Sham rats. Treatment with HIIT using ES for Nx rats significantly improved these molecular and functional changes to the same degrees as those in Sham rats. Furthermore, a single session of HIIT with ES significantly increased the phosphorylation levels of AMP-activated protein kinase (AMPK) and p38 mitogen-activated protein kinase (MAPK), pathways that are essential for mitochondrial activation signaling by exercise, in the plantar muscles of both Nx and Sham rats. CONCLUSION: The findings suggest that HIIT using ES ameliorates muscle fatigue in Nx rats via restoration of mitochondrial respiratory dysfunction with activation of AMPK and p38 MAPK signaling. Our ES-based HIIT protocol can be performed without placing a burden on the whole body and be a promising intervention that is implemented even in conditions of reduced general performance status such as CKD-related cachexia.

    DOI： 10.3389/fphys.2024.1423504

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  • Skeletal muscle endurance declines with impaired mitochondrial respiration and inadequate supply of acetyl-CoA during muscle fatigue in 5/6 nephrectomized rats. Reviewed International journal

    Hiroyori Fusagawa, Tatsuya Sato, Takashi Yamada, Yuki Ashida, Iori Kimura, Azuma Naito, Nao Tokuda, Nao Yamauchi, Nobutoshi Ichise, Yoshinori Terashima, Izaya Ogon, Atsushi Teramoto, Toshihiko Yamashita, Noritsugu Tohse

    Journal of applied physiology (Bethesda, Md. : 1985)   2023.8

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    Chronic kidney disease (CKD)-related cachexia increases the risks of reduced physical activity and mortality. However, the physiological phenotype of skeletal muscle fatigue and changes in intramuscular metabolites during muscle fatigue in CKD-related cachexia remain unclear. In the present study, we performed detailed muscle physiological evaluation, analysis of mitochondrial function, and comprehensive analysis of metabolic changes before and after muscle fatigue in a 5/6 nephrectomized rat model of CKD. Wistar rats were randomized to a sham-operation (Sham) group that served as a control group or a 5/6 nephrectomy (Nx) group. Eight weeks after the operation, in situ torque and force measurements in plantar flexor muscles in Nx rats using electrical stimulation revealed a significant decrease in muscle endurance during subacute phase related to mitochondrial function. Muscle mass was reduced without changes in the proportions of fiber type-specific myosin heavy chain isoforms in Nx rats. Pyruvate-malate-driven state 3 respiration in isolated mitochondria were impaired in Nx rats. Protein expression levels of mitochondrial respiratory chain complexes III and V were decreased in Nx rats. Metabolome analysis revealed that the increased supply of acetyl CoA in response to fatigue was blunted in Nx rats. These findings suggest that CKD deteriorates skeletal muscle endurance in association with mitochondrial dysfunction and inadequate supply of acetyl-CoA during muscle fatigue.

    DOI： 10.1152/japplphysiol.00226.2023

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  • Enhanced glucose metabolism through activation of HIF-1α covers the energy demand in a rat embryonic heart primordium after heartbeat initiation. Reviewed International journal

    Tatsuya Sato, Nobutoshi Ichise, Takeshi Kobayashi, Hiroyori Fusagawa, Hiroya Yamazaki, Taiki Kudo, Noritsugu Tohse

    Scientific reports   12 ( 1 )   74 - 74   2022.1

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    The initiation of heartbeat is an essential step in cardiogenesis in the heart primordium, but it remains unclear how intracellular metabolism responds to increased energy demands after heartbeat initiation. In this study, embryos in Wistar rats at embryonic day 10, at which heartbeat begins in rats, were divided into two groups by the heart primordium before and after heartbeat initiation and their metabolic characteristics were assessed. Metabolome analysis revealed that increased levels of ATP, a main product of glucose catabolism, and reduced glutathione, a by-product of the pentose phosphate pathway, were the major determinants in the heart primordium after heartbeat initiation. Glycolytic capacity and ATP synthesis-linked mitochondrial respiration were significantly increased, but subunits in complexes of mitochondrial oxidative phosphorylation were not upregulated in the heart primordium after heartbeat initiation. Hypoxia-inducible factor (HIF)-1α was activated and a glucose transporter and rate-limiting enzymes of the glycolytic and pentose phosphate pathways, which are HIF-1α-downstream targets, were upregulated in the heart primordium after heartbeat initiation. These results suggest that the HIF-1α-mediated enhancement of glycolysis with activation of the pentose phosphate pathway, potentially leading to antioxidant defense and nucleotide biosynthesis, covers the increased energy demand in the beating and developing heart primordium.

    DOI： 10.1038/s41598-021-03832-5

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  • Ultrastructural Assessment and Proteomic Analysis in Myofibrillogenesis in the Heart Primordium After Heartbeat Initiation in Rats. Reviewed International journal

    Nobutoshi Ichise, Tatsuya Sato, Hiroyori Fusagawa, Hiroya Yamazaki, Taiki Kudo, Izaya Ogon, Noritsugu Tohse

    Frontiers in physiology   13   907924 - 907924   2022

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    Myofibrillogenesis is an essential process for cardiogenesis and is closely related to excitation-contraction coupling and the maintenance of heartbeat. It remains unclear whether the formation of myofibrils and sarcomeres is associated with heartbeat initiation in the early embryonic heart development. Here, we investigated the association between the ultrastructure of myofibrils assessed by transmission electron microscopy and their proteomic profiling assessed by data-independent acquisition mass spectrometry (DIA-MS) in the rat heart primordia before and after heartbeat initiation at embryonic day 10.0, when heartbeat begins in rats, and in the primitive heart tube at embryonic day 11.0. Bundles of myofilaments were scattered in a few cells of the heart primordium after heartbeat initiation, whereas there were no typical sarcomeres in the heart primordia both before and after heartbeat initiation. Sarcomeres with Z-lines were identified in cells of the primitive heart tube, though myofilaments were not aligned. DIA-MS proteome analysis revealed that only 43 proteins were significantly upregulated by more than 2.0 fold among a total of 7,762 detected proteins in the heart primordium after heartbeat initiation compared with that before heartbeat initiation. Indeed, of those upregulated proteins, 12 (27.9%) were constituent proteins of myofibrils and 10 (23.3%) were proteins that were accessories and regulators for myofibrillogenesis, suggesting that upregulated proteins that are associated with heartbeat initiation were enriched in myofibrillogenesis. Collectively, our results suggest that the establishment of heartbeat is induced by development of bundles of myofilaments with upregulated proteins associated with myofibrillogensis, whereas sarcomeres are not required for the initial heartbeat.

    DOI： 10.3389/fphys.2022.907924

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  • Response to exercise-induced blood pressure elevation is blunted in wrist-cuff automated oscillometric measurement in healthy young college students. Reviewed International journal

    Tatsuya Sato, Nobutoshi Ichise, Yoshinori Terashima, Aoi Kato, Hiroya Yamazaki, Shunsuke Jimbo, Noritsugu Tohse

    Physiological reports   8 ( 17 )   e14570   2020.9

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    BACKGROUND: A wrist-cuff automated oscillometric device is portable and useful for self-monitoring of blood pressure (BP) at home and outdoors when an upper arm device is not available. Although the height of the forearm in wrist BP measurement is acknowledged to be the major cause of measurement error, it remains unclear whether exercise affects subsequent wrist BP measurement. METHODS AND RESULTS: Ninety-seven healthy college students (median age of 20 years with an age range of 19 to 36 years, 70.1% males) participated in this study. Care was taken to keep the position of the wrist at a level near the upper arm level in BP measurement. At rest, BP measured by a wrist-cuff oscillometric device (Omron HEM-6183) was generally acceptable when it was compared with BP measured by an upper arm oscillometric device (Omron HEM-7130-HP) and with BP measured by the auscultatory method using a mercury sphygmomanometer. However, the ratio of systolic BP measured by oscillometric devices just after a two-step exercise test to that before exercise on the wrist (1.22 ± 0.14) was significantly lower than the ratio on the upper arm (1.27 ± 0.14), and the difference was significantly correlated with exercise-induced increase in pulse rate (Spearman's ρ = 0.23), suggesting a possible role of autonomic nerve activity in the blunted response to exercise-induced BP elevation in wrist BP measurement. CONCLUSIONS: The results indicate that the blunted response to exercise-induced BP elevation should be considered in wrist BP measurement when using a wrist-cuff oscillometric device.

    DOI： 10.14814/phy2.14570

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  • Antinociceptive effects of hyaluronic acid on monoiodoacetate-induced ankle osteoarthritis in rats. Reviewed International journal

    Jimbo S, Terashima Y, Teramoto A, Takebayashi T, Ogon I, Watanabe K, Sato T, Ichise N, Tohse N, Yamashita T

    Journal of pain research   12   191 - 200   2019

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    Purpose: Ankle osteoarthritis (OA) causes significant pain and debilitation; yet, its underlying mechanisms remain unclear. Clinically, hyaluronic acid (HA) is widely used to treat OA. The present study aimed to investigate the roles of HA in pain-related behavior, joint function, swelling, and pathological changes in cartilage in a rat model of monoiodoacetate (MIA)-induced ankle OA. Materials and methods: Male Sprague Dawley rats were assigned to three experimental groups as follows: 1) MIA rats injected with 1 mg MIA in the right tibiotarsal joint for two consecutive days; 2) sham rats injected with saline instead of MIA; and 3) MIA-HA rats injected with HA in the tibiotarsal joint at 7, 14, and 21 days after MIA injection. Joint swelling, range of motion (ROM), and pain-related behavior were evaluated 1 day before and on the 7th, 14th, 21st, and 28th day after MIA or saline injection. Pathological changes in the ankle joint were assessed 28 days after MIA or saline injection. Results: No significant difference in the degree of ankle swelling or ROM reduction was observed between MIA rats and MIA-HA rats. However, compared with those in MIA rats, mechanical and thermal hypersensitivity was significantly reduced and stride length significantly improved in MIA-HA rats. Histologic analysis revealed that cartilage degeneration was significantly suppressed in MIA-HA rats compared with that in MIA rats, reflecting the chondroprotective effects of HA. Conclusion: HA improved pain-related behavior and stride length and suppressed MIA-induced cartilage degeneration. HA may thus inhibit OA progression and suppress peripheral and/or central sensitization.

    DOI： 10.2147/JPR.S186413

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  • Analgesic effects of calcitonin on radicular pain in male rats. Reviewed International journal

    Terashima Y, Takebayashi T, Jimbo S, Ogon I, Sato T, Ichise N, Tohse N, Yamashita T

    Journal of pain research   12   223 - 230   2019

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    Purpose: Radicular pain is a frequently observed symptom of lumbar disk herniation or lumbar spinal canal stenosis. Achieving radicular pain relief is difficult. This type of pain may progress to chronic neuropathic pain. Calcitonin (elcatonin [eCT]) has been used mainly for hypercalcemia and pain associated with osteoporosis. The purpose of this study was to investigate analgesic effects of repeated eCT administration on radicular pain in male rats and changes in mRNA-expression levels of voltage-dependent sodium channels in the dorsal root ganglion (DRG). Methods: Seventy male Sprague-Dawley rats were used. A right L5 hemilaminectomy and an L5-L6 partial facetectomy were performed to expose the right L5 nerve root. Under a microscope, the right L5 spinal nerve root was tightly ligated extradurally with 8-0 nylon suture proximally to the DRG to cause radicular pain in rats. Mechanical hyperalgesia, thermal hyperalgesia, and analgesic effects of eCT were compared among rats with radicular pain that received eCT, those that received the vehicle, and sham rats that received the vehicle. Real-time reverse-transcription PCR was performed to measure mRNA-expression levels of tetrodotoxin-sensitive (NaV1.3 and NaV1.6) and tetrodotoxin-resistant (NaV1.8 and NaV1.9) sodium channels in the DRG. Results: Mechanical and thermal hyperalgesic reactions occurring in rats with radicular pain significantly improved on days 5 and 9 of eCT administration, respectively. In rats with radicular pain, mRNA-expression levels of NaV1.3, NaV1.8, and NaV1.9 increased. After repeated eCT administration, mRNA-expression levels of these sodium channels in rats with radicular pain improved to the same levels as in sham rats. Conclusion: The present study demonstrated that repeated systemic eCT administration was effective for radicular pain. No serious side effects of eCT have been reported thus far. Therefore, calcitonin may be a preferred therapeutic option for patients with radicular pain or for those requiring long-term treatment.

    DOI： 10.2147/JPR.S185233

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  • A Novel Rat Model of Ankle Osteoarthritis Induced by the Application of Monoiodoacetate Reviewed

    Journal of Arthritis   6 ( 6 )   2017.11

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  • The beginning of the calcium transient in rat embryonic heart Reviewed

    Takeshi Kobayashi, Sachiko Maeda, Nobutoshi Ichise, Tatsuya Sato, Takehito Iwase, Sumihiko Seki, Yoichi Yamada, Noritsugu Tohse

    JOURNAL OF PHYSIOLOGICAL SCIENCES   61 ( 2 )   141 - 149   2011.3

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    DOI： 10.1007/s12576-010-0131-x

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  • Enhancement of the nitrogen fixation efficiency of genetically-engineered Rhizobium with high catalase activity Reviewed

    Yoshitake Orikasa, Yoshinobu Nodasaka, Takuji Ohyama, Hidetoshi Okuyama, Nobutoshi Ichise, Isao Yumoto, Naoki Morita, Min Wei, Takuji Ohwada

    JOURNAL OF BIOSCIENCE AND BIOENGINEERING   110 ( 4 )   397 - 402   2010.10

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    DOI： 10.1016/j.jbiosc.2010.04.007

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  • H2O2 tolerance of Vibrio rumoiensis S-1(T) is attributable to the cellular catalase activity Reviewed

    Nobutoshi Ichise, Kikue Hirota, Daisen Ichihashi, Yoshinobu Nodasaka, Naoki Morita, Hidetoshi Okuyama, Isao Yumoto

    JOURNAL OF BIOSCIENCE AND BIOENGINEERING   106 ( 1 )   39 - 45   2008.7

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    DOI： 10.1263/jbb.106.39

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  • Cytochrome c-552 from gram-negative alkaliphilic Pseudomonas alcaliphila AL15-21(T) alters the redox properties at high pH Reviewed

    Toshihide Matsuno, Nozomu Morishita, Koji Yamazaki, Norio Inoue, Yukari Sato, Nobutoshi Ichise, Isao Hara, Tamotsu Hoshino, Hidetoshi Matsuyama, Kazuaki Yoshimune, Isao Yumoto

    JOURNAL OF BIOSCIENCE AND BIOENGINEERING   103 ( 3 )   247 - 254   2007.3

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    DOI： 10.1263/jbb.103.247

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  • 新しい医療技術の普及と知的財産教育のあり方について－医療と技術移転の現場からー Reviewed

    Patent   60 ( 2 )   48 - 54   2007.2

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  • Relationship between the size of the bottleneck 15 angstrom from iron in the main channel and the reactivity of catalase corresponding to the molecular size of substrates Reviewed

    Isao Hara, Nobutoshi Ichise, Kiyoshi Kojima, Hidemasa Kondo, Satoru Ohgiya, Hidetoshi Matsuyama, Isao Yumoto

    BIOCHEMISTRY   46 ( 1 )   11 - 22   2007.1

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    DOI： 10.1021/bi061519w

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  • Cultivation of microorganisms in the cultural medium made from squid internal organs and accumulation of polyunsaturated fatty acids in the cells Reviewed

    N Morita, N Ichise, Yumoto, I, Y Yano, S Ohgiya, H Okuyama

    BIOTECHNOLOGY LETTERS   27 ( 13 )   933 - 941   2005.7

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    DOI： 10.1007/s10529-005-7187-3

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  • Molecular biological basis and physiological significance of extraordinarily high catalase activity in Vibrio rumoiensis S-1

    Nobutoshi Ichise

    2003.9

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    Authorship：Corresponding author   Language：English   Publishing type：Doctoral thesis  

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  • Dynamic turnover of arabinogalactan proteins in cultured Arabidopsis cells Reviewed

    L Darjania, N Ichise, S Ichikawa, T Okamoto, H Okuyama, GA Thompson

    PLANT PHYSIOLOGY AND BIOCHEMISTRY   40 ( 1 )   69 - 79   2002.1

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  • Metabolism of glycosylphosphatidylinositol-anchored proteins in Arabidopsis Reviewed

    L Darjania, N Ichise, S Ichikawa, T Okamoto, H Okuyama, GA Thompson

    BIOCHEMICAL SOCIETY TRANSACTIONS   28 ( 6 )   725 - 727   2000.12

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    DOI： 10.1042/0300-5127:0280725

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  • Gene cloning and expression of the catalase from the hydrogen peroxide-resistant bacterium Vibrio rumoiensis S-1 and its subcellular localization Reviewed

    N Ichise, N Morita, K Kawasaki, Yumoto, I, H Okuyama

    JOURNAL OF BIOSCIENCE AND BIOENGINEERING   90 ( 5 )   530 - 534   2000.11

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  • Purification and characterization of a catalase from the facultatively psychrophilic bacterium Vibrio rumoiensis S-1(T) exhibiting high catalase activity Reviewed

    Yumoto, I, D Ichihashi, H Iwata, A Istokovics, N Ichise, H Matsuyama, H Okuyama, K Kawasaki

    JOURNAL OF BACTERIOLOGY   182 ( 7 )   1903 - 1909   2000.4

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    DOI： 10.1128/JB.182.7.1903-1909.2000

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  • Lytic activity and biochemical properties of lysozyme in the coelomic fluid of the sea urchin Strongylocentrotus intermedius Reviewed

    M Shimizu, S Kohno, H Kagawa, N Ichise

    JOURNAL OF INVERTEBRATE PATHOLOGY   73 ( 2 )   214 - 222   1999.3

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    DOI： 10.1006/jipa.1998.4808

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  • A mechanism of resistance to hydrogen peroxide in Vibrio rumoiensis S-1 Reviewed

    N Ichise, N Morita, T Hoshino, K Kawasaki, Yumoto, I, H Okuyama

    APPLIED AND ENVIRONMENTAL MICROBIOLOGY   65 ( 1 )   73 - 79   1999.1

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  • Characterization of a facultatively psychrophilic bacterium, Vibrio rumoiensis sp. nov., that exhibits high catalase activity Reviewed

    Yumoto, I, H Iwata, T Sawabe, K Ueno, N Ichise, H Matsuyama, H Okuyama, K Kawasaki

    APPLIED AND ENVIRONMENTAL MICROBIOLOGY   65 ( 1 )   67 - 72   1999.1

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Books

  • 産学官連携の「質」の向上方策に関する調査研究報告書

    （ Role： Contributor）

    新技術振興渡辺記念会  2009.5 

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  • 産学官連携コーディネーターの成功・失敗事例に学ぶー産学官連携の新たな展開に向けてー

    （ Role： Edit）

    文部科学省研究振興局研究環境産業連携課  2006.6 

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MISC

  • Global Deletion of AMP Deaminase 3 (AMPD3) Exacerbates Diabetes Mellitus-Induced Sarcopenia in Mice. Reviewed

    The Journal of Physiological Sciences   75 ( 1,Supplement )   2025.3

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  • Characteristics of changes in tissue non-heme iron contents in different fatigue rat models. Reviewed

    Takuro Karaushi, Toshifumi Ogawa, Nobutoshi Ichise, Noritsugu Tohse, Tatsuya Sato

    The Journal of Physiological Sciences   75 ( 1,Supplement )   2025.3

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  • Evaluation of oxygen consumption through respiratory chain complexes using fatty acids as substrates in isolated rat heart mitochondria. Reviewed

    Tatsuya Sato, Yuki Tatekoshi, Nobutshi Ichise, Toshifumi Ogawa, Takuro Karaushi, Atsushi Kuno

    The Journal of Physiological Sciences   75 ( 1,Supplement )   2025.3

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  • The Inward Current Mediated by Cav1.3 with Insulin-like Growth Factor Axis Activation Is One of the Predominant Pacemakers of the Rat Fetal Heart during Early Development. Reviewed

    Nobutioshi Ichise, Toshifumi Ogawa, Takuro Karaushi, Noritsugu Tohse, Tatsuya Sato

    The Journal of Physiological Sciences   75 ( 1,Supplement )   2025.3

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  • Characteristics of plasma iron metabolism in peripheral and central fatigue models in rats Reviewed

    TAKURO KARAUSHI, TATSUYA SATO, NOBUTOSHI ICHISE, HIROYORI, FUSAGAWA, TOSHIFUMI OGAWA, TAIKI KUDO, NORITSUGU TOHSE

    JOURNAL OF PHYSIOLOGICAL SCIENCES   74 ( Supplement 2 )   145 - 145   2024.5

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  • Elucidation of the muscle pathophysiology in overuse using a repetitive isometric contraction model with electrical stimulation Reviewed

    Hiroyori Fusagawa, Takashi Yamada, Tatsuya Sato, Azuma Naito, Nao Tokuda, Nao Yamauchi, Nobutoshi Ichise, Takuro Karaushi, Toshifumi Ogawa, Atsushi, Teramoto, Noritsugu Tohse

    JOURNAL OF PHYSIOLOGICAL SCIENCES   74 ( Supplement 2 )   177 - 177   2024.5

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  • 末梢性疲労モデルラットと中枢性疲労モデルラットにおける鉄代謝の特徴の検討

    唐牛拓郎, 佐藤達也, 一瀬信敏, 房川祐頼, 小川俊史, 當瀬規嗣

    日本疲労学会誌   20 ( 1 )   2024

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  • Roles of mitochondria in energy metabolism after heartbeat initiation in the heart primordium of the rat embryo Reviewed

    Tatsuya Sato, Nobutoshi Ichise, Toshifumi Ogawa, Takuro Karaushi, Hiroyori Fusagawa, Taiki Kudo, Noritsugu Tohse

    The 10th FAOPS congress.   2023.11

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  • Mechanism of metabolic adaptation in the heart primordium just after heartbeat initiation in the early embryonic development in rats

    TATSUYA SATO, NOBUTOSHI ICHISE, HIROYORI FUSAGAWA, TAKURO KARAUSHI, TAIKI KUDO, NORITSUGU TOHSE

    JOURNAL OF PHYSIOLOGICAL SCIENCES   73 ( Supplement 1 )   106 - 106   2023.5

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  • Assessment of myofibrillogenesis in rat embryonic hearts in the initiation of heartbeats by transmission electron microscopy and evaluation of its molecular expression patterns by proteomic analysis.

    NOBUTOSHI ICHISE, TATSUYA SATO, TAKURO KARAUSHI, HIROYORI FUSAGAWA, TAIKI KUDO, NORITSUGU TOHSE

    JOURNAL OF PHYSIOLOGICAL SCIENCES   73 ( Supplement 1 )   154 - 154   2023.5

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  • Proteomic analysis of the metabolic pathway involved in the developmental process of cardiac primordium just after heartbeat initiation to primordial heart tube formation in rats.

    TAKURO KARAUSHI, Tatsuya Sato, Nobutoshi Ichise, Hiroyori Fusagawa, Taiki Kudo, Noritsugu Tohse

    JOURNAL OF PHYSIOLOGICAL SCIENCES   73 ( Supplement 1 )   98 - 98   2023.5

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  • Effect of high-intensity interval training using electrical stimulation on mitochondrial dysfunction and muscle fatigue in 5/6 nephrectomy rat model of chronic kidney disease

    Hiroyori Fusagawa, Takashi Yamada, Tatsuya Sato, Yuki Ashida, Azuma Naito, Nao Tokuda, Nao Yamauchi, Nobutoshi Ichise, Takuro Karaushi, Atsushi Teramoto, Toshihiko Yamashita, Noritsugu Tohse

    JOURNAL OF PHYSIOLOGICAL SCIENCES   73 ( Supplement 1 )   99 - 99   2023.5

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  • High-intensity interval training using electrical stimulation improves mitochondrial dysfunction and muscle endurance in rats with chronic kidney disease

    Hiroyori Fusagawa, Takashi Yamada, Tatsuya Sato, Yuki Ashida, Asuma Naito, Nao Tokuda, Nao Yamauchi, Nobutoshi Ichise, Takuro Karaushi, Atsushi Teramoto, Toshihiko Yamashita, Noritsugu Tohse

    Biophysical Journal   122 ( 3 )   114a - 114a   2023.2

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    DOI： 10.1016/j.bpj.2022.11.793

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  • 慢性腎不全モデルラットではミトコンドリア機能障害を伴い筋疲労耐性が低下する

    房川 祐頼, 佐藤 達也, 山田 崇史, 芦田 雪, 一瀬 信敏, 寺島 嘉紀, 寺本 篤史, 當瀬 規嗣, 山下 敏彦

    日本整形外科学会雑誌   95 ( 8 )   S1716 - S1716   2021.8

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    Ichushi

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  • Characteristics of blood pressure measurement by wrist-cuff automated oscillometric measurement at rest and after exercise in healthy college students

    Hiroya Yamazaki, Tastuya Sato, Nobutoshi Ichise, Yoshinori Terashima, Aoi Kato, Noritsugu Tohse

    JOURNAL OF PHYSIOLOGICAL SCIENCES   70 ( Supplement 1 )   105 - 105   2020.5

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  • Energy Metabolism in Rat Fetal Hearts Just after the Initiation of Heartbeat is Altered via Increased Glycolytic Flux and Activated Mitochondrial Function

    Tatsuya Sato, Nobutoshi Ichise, Hiroya Yamazaki, Yoshinori Terashima, Noritsugu Tohse

    BIOPHYSICAL JOURNAL   118 ( 3 )   407A - 408A   2020.2

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  • Initiation of the heartbeat in rat embryonic heart precedes sarcomere formation.

    Nobutoshi Ichise, Tatsuya Sato, Hiroya Yamazaki, Yoshinori Terashima, Syunsuke Jimbo, Noritsugu Tohse

    JOURNAL OF PHYSIOLOGICAL SCIENCES   69   S111 - S111   2019.3

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  • Transcripts associated with glycolysis are increased in rat embryonic heart just after the initiation of the heartbeat.

    Sato Tatsuya, Ichise Nobutoshi, Kobayashi Takeshi, Terashima Yoshinori, Takahashi Nobuyuki, Jimbo Syunsuke, Tohse Noritsugu

    The Journal of Physiological Sciences   68 ( S1 )   S73   2018.3

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  • Is morphology of intracellular organelle altered just after initiation of cardiac contraction?

    Nobutoshi Ichise, Tatsuya Sato, Yoshinori Terashima, Nobuyuki Takahashi, Hiroya Yamazaki, Syunsuke Jimbo, Noritsugu Tohse

    JOURNAL OF PHYSIOLOGICAL SCIENCES   68   S143 - S143   2018.3

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  • Antinociceptive effect of hyaluronic acid sodium on ankle osteoarthritis model

    Jimbo Syunsuke, Terashima Yoshinori, Takebayashi Tsuneo, Ichise Nobutoshi, Sato Tatsuya, Teramoto Atsushi, Yamashita Toshihiko, Tohse Noritsugu

    The Journal of Physiological Sciences   68 ( S1 )   S72   2018.3

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  • Sympathectomy and sympathetic blockade reduce pain behavior via alpha-2 adrenoceptor of the dorsal root ganglion neurons in a lumbar radiculopathy model

    Ogon Izaya, Kobayashi Takeshi, Ichise Nobutoshi, Maeda Sachiko, Tohse Noritsugu

    The Journal of Physiological Sciences   66 ( S1 )   S82   2016.1

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  • Development of Electric Characteristics in Rat Heart

    35 ( 1 )   61 - 64   2015.7

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  • Local application of sympathetic nerve blockers around dorsal root ganglion reduces painful behavior in a lumbar radiculopathy model

    Ogon, Izaya, Kobayashi, Takeshi, Maeda, Sachiko, Ichise, Nobutoshi, Tohse, Noritsugu

    The Journal of Physiological Sciences   65 ( S1 )   S258   2015.1

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    Publisher：Springer Science and Business Media LLC  

    Other Link:： http://link.springer.com/article/10.1007/BF03405847/fulltext.html

    DOI： 10.1007/bf03405847

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  • The developmental changes in the contractile proteins of rat embryonic hearts around the period of the appearance of the heartbeat

    Kobayashi, Takeshi, Maeda, Sachiko, Ichise, Nobutoshi, Miyakawa, Tsuyoshi, Ogon, Izaya, Yamada, Yoichi, Tohse, Noritsugu

    The Journal of Physiological Sciences   64 ( S1 )   S133   2014.1

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    Publisher：Springer Science and Business Media LLC  

    Other Link:： http://link.springer.com/article/10.1007/BF03405837/fulltext.html

    DOI： 10.1007/bf03405837

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  • 心拍動開始後のラット胎生心における電位依存性内向き電流の特徴

    一瀬 信敏, 佐藤 達也, 小林 武志, 前田 佐知子, 當瀬 規嗣

    心電図   33 ( Suppl.4 )   S - 147   2013.9

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    Ichushi

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  • High sensitivity Western blotting method revealed the developmental changes in the contractile proteins of rat embryonic hearts

    Takeshi Kobayashi, Sachiko Maeda, Nobutoshi Ichise, Tatsuya Sato, Tsuyoshi Miyakawa, Yoichi Yamada, Noritsugu Tohse

    JOURNAL OF PHYSIOLOGICAL SCIENCES   63   S122 - S122   2013

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  • Characteristics of voltage dependent inward current in the rat embryonic heart early after the initiation of heartbeat

    Tatsuya Sato, Nobutoshi Ichise, Takeshi Kobayashi, Sachiko Maeda, Noritsugu Tohse

    JOURNAL OF PHYSIOLOGICAL SCIENCES   63   S230 - S230   2013

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  • Characteristics of Left Ventricular Contractility and Action Potential in Heart of Obese Type2 Diabetes Rats

    SATO Tatsuya, TAKADA Akifumi, HOTTA Hiroyuki, MIKI Takayuki, TANNO Masaya, KOBAYASHI Takeshi, MAEDA Sachiko, ICHISE Nobutoshi, KUNO Atsushi, KOHZU Hidemichi, ITOH Takahito, SUNAGA Daisuke, ISHIKAWA Satoko, MIURA Tetsuji, TOHSE Noritsugu

    Circulation Journal   75 ( Supplement 1(CD-ROM) )   2011

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  • Expression of L-type calcium channel Ca(v)1.3 and sarcomeric-related proteins in the period of heartbeat initiation in the early rat embryo

    Sachiko Maeda, Takeshi Kobayashi, Nobutoshi Ichise, Tatsuya Sato, Takehito Iwase, Noritsugu Tohse

    JOURNAL OF PHARMACOLOGICAL SCIENCES   115   264P - 264P   2011

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  • The relationship between contraction and calcium transient of heart primordium at the beginning of heart beat of rat embryos

    Takeshi Kobayashi, Sachiko Maeda, Nobutoshi Ichise, Takanori Kobayashi, Takehito Iwase, Yoichi Yamada, Noritsugu Tohse

    JOURNAL OF PHYSIOLOGICAL SCIENCES   60   S93 - S93   2010

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  • Expression of L-type calcium channel Ca(v)1.2 and Ca-v beta 2 contribute to action potential configuration in the period of heartbeat initiation in the early rat embryo

    Sachiko Maeda, Takeshi Kobayashi, Nobutoshi Ichise, Takanori Kobayashi, Takehito Iwase, Yoichi Yamada, Noritsugu Tohse

    JOURNAL OF PHARMACOLOGICAL SCIENCES   112   201P - 201P   2010

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  • Expression of ionic channels contribute to action potential configuration in the period of heartbeat initiation in the early rat embryo

    Sachiko Maeda, Takeshi Kobayashi, Nobutoshi Ichise, Takehito Iwase, Yoichi Yamada, Noritsugu Tohse

    JOURNAL OF PHYSIOLOGICAL SCIENCES   60   S160 - S160   2010

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  • INITIATION OF HEART BEAT IN RAT EMBRYOS

    Takeshi Kobayashi, Sachiko Maeda, Nobutoshi Ichise, Takanori Kobayashi, Katsumasa Tanimoto, Kaori Shiratori, Junichi Satoh, Noritsugu Tohse

    JOURNAL OF PHYSIOLOGICAL SCIENCES   59   230 - 230   2009

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  • L-type Ca(v)1.2 calcium channel is initially expressed in a heart-restricted pattern within the early rat embryo

    Sachiko Maeda, Takeshi Kobayashi, Nobutoshi Ichise, Takanori Kobayashi, Katsumasa Tanimoto, Kaori Shiratori, Noritsugu Tohse

    JOURNAL OF PHARMACOLOGICAL SCIENCES   109   139P - 139P   2009

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  • EXPRESSION OF L-TYPE CALCIUM CHANNEL Ca-v alpha(1) AND Ca-v beta(2) SUBUNITS IN A HEART-RESTRICTED PATTERN WITHIN THE EARLY RAT EMBRYO

    Sachiko Maeda, Takeshi Kobayashi, Nobutoshi Ichise, Takanori Kobayashi, Katsumasa Tanimoto, Kaori Shiratori, Junichi Satoh, Noritsugu Tohse

    JOURNAL OF PHYSIOLOGICAL SCIENCES   59   230 - 230   2009

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  • 日本の大学の技術移転に効果的な知財ポリシーとは

    一瀬信敏, 石埜正穂

    日本知財学会第6回年次学術研究発表会要旨集   2008.6

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  • 知財活用分野における大学間協定の運用に関する調査

    一瀬信敏, 石埜正穂

    日本知財学会第5回年次学術研究発表会要旨集   210 - 213   2007.6

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  • Catalase

    IPOD Technical Reports   5 ( 5 )   1 - 8   2006.10

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    Language：Japanese   Publishing type：Article, review, commentary, editorial, etc. (bulletin of university, research institution)  

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  • 研究課題の可視化による札幌医科大学の研究活動の網羅的分析とその応用

    一瀬信敏, 黒須成弘, 石埜正穂

    日本知財学会第4回年次学術研究発表会要旨集   240 - 243   2006.6

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  • Vibrio rumoiensis S-1 カタラーゼの酵素学的性質およびその応用

    湯本勲, 森下望, 一瀬信敏, 森田直樹, 山崎浩司, 猪上徳雄, 奥山英登史志

    第７回生体触媒化学シンポジウム   2003.12

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  • 植物におけるグリコシルホスファチジルイノシトールアンカータンパク質の代謝について

    一瀬信敏, Levan Darjania, 市川聡子, 岡本貴史, 奥山英登志, Guy A. Thompson Jr

    第42回日本植物生理学会年会講演要旨集   2001.3

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  • On the Metabolism of Glycosylphosphatidylinositolanchored Proteins in Plants :

    Darjania Levan, Ichise Nobutoshi, Ichikawa Satoko, Okamoto Takashi, Okuyama Hidetoshi, Thompson Guy A.

    Plant and cell physiology   42 ( 0 )   s194   2001

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    Language：English   Publisher：Japanese Society of Plant Physiologists  

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  • 高カタラーゼ細菌を利用した過酸化水素含有廃液の処理法

    2000

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  • Application of catalase activity of facultatively psychrophilic bacterium Vibrio rumoiensis S-1 to decompose hydrogen peroxide in industrial waste

    Yumoto Isao, Ichihashi Daisen, Iwata Hideaki, Kawasaki Kosei, Matsuyama Hidetoshi, Ichise Nobutoshi, Okuyama Hidetoshi

    12   392 - 392   2000

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  • 過酸化水素耐性菌Vibrio rumoiensis のカタラーゼ遺伝子のクローニング

    一瀬 信敏, 星野 保, 森田 直樹, 川崎公誠, 湯本 勲, 奥山 英登志

    日本農芸化学会大会講演要旨集   1999.4

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  • Enzymatic activity of Vibrio rumoiensis S-1 catalase

    Yumoto Isao, Ichihashi Daisen, Iwata Hideaki, Istokovics Anita, Ichise Nobutoshi, Matsuyama Hidetoshi, Okuyama Hidetoshi, Kawasaki Kosei

    11   38 - 38   1999

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  • Vibrio rumoiensis の過酸化水素存在下での生存について

    一瀬 信敏, 星野 保, 森田 直樹, 川崎公誠, 湯本 勲, 奥山 英登志

    日本農芸化学会北海道支部合同学術講演会要旨集   1998.11

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  • Isolation of Vibrio sp. S-1 Exhibiting Extraordinarily High Catalase Activity Reviewed

    YUMOTO Isao, YAMAZAKI Koji, KAWASAKI Kosei, ICHISE Nobutoshi, MORITA Naoki, HOSHINO Tamotsu, OKUYAMA Hidetoshi

    Journal of Fermentation and Bioengineering   85 ( 1 )   113 - 116   1998.1

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  • Productivity of catalase by Vibrio sp. S-1

    Yumoto Isao, Iwata Hideaki, Ueno Keisuke, Ichise Nobutoshi, Okuyama Hidetoshi, Kawasaki Kosei

    10   91 - 91   1998

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  • 過酸化水素耐性細菌Vibrio sp. S-1株のカタラーゼ遺伝子について

    一瀬信敏, 湯本勲, 岩田秀明, 星野保, 森田直樹, 奥山英登志

    第61回日本植物学会大会講演要旨集   1997.9

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  • Effect of cultural conditions on the synthesis of catalase by Vibrio sp. S-1

    Yumoto Isao, Iwata Hideaki, Kawasaki Kosei, Ichise Nobutoshi, Mastuyama Hidetoshi, Okuyama Hidetoshi

    9   78 - 78   1997

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  • 過酸化水素耐性細菌Vibrio sp. S-1株のカタラーゼの精製とその性質

    一瀬信敏, 湯本勲, 岩田秀明, Istokovics Anita, 森田直樹, 奥山英登志

    第60回日本植物学会大会講演要旨集   60   181 - 181   1996.10

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  • Catalase

    19   120 - 120   1996.8

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  • リン酸飢餓状態下で誘導されるSpirodera oligorrhizaの低分子量ホスファターゼの精製と性質

    一瀬信敏, 澤田美智子, 石川 鑛, 奥山英登志

    第37回日本植物生理学会年会講演要旨集   1996.3

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Research Projects

  • Roles of Ferroptosis in Steatotic Liver Disease as a Pathophysiology of Cardiovascular, Kidney, and Metabolic (CKM) Syndrome

    Grant number：25K11392  2025.4 - 2028.3

    Japan Society for the Promotion of Science  Grants-in-Aid for Scientific Research  Grant-in-Aid for Scientific Research (C)

    Tatsuya Sato, Megumi Watanabe, Nobutoshi Ichise, Toshifumi Ogawa

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  • 低酸素誘導因子1α が胎生初期心臓原基の拍動開始および拍動維持に及ぼす影響の検討

    Grant number：22K06846  2022.4 - 2025.3

    Japan Society for the Promotion of Science  Grants-in-Aid for Scientific Research Grant-in-Aid for Scientific Research (C)  Grant-in-Aid for Scientific Research (C)

    當瀬 規嗣, 佐藤 達也, 一瀬 信敏

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    Grant amount：\4160000 （ Direct Cost: \3200000 、 Indirect Cost：\960000 ）

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  • A study of mitochondrial function on the mechanisms of heartbeat initiation in embryonic heart

    Grant number：19K07286  2019.4 - 2022.3

    Japan Society for the Promotion of Science  Grants-in-Aid for Scientific Research Grant-in-Aid for Scientific Research (C)  Grant-in-Aid for Scientific Research (C)

    Noritsugu Tohse

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    Grant amount：\4420000 （ Direct Cost: \3400000 、 Indirect Cost：\1020000 ）

    The initiation of heartbeat is an essential step in cardiogenesis in the heart primordium, but it remains unclear how intracellular metabolism responds to increased energy demands after heartbeat initiation. Myofibrillogenesis is an essential process for cardiogenesis and is closely related to excitation-contraction coupling and the maintenance of heartbeat. However, how myofibrils and sarcomeres are associated with heartbeat initiation in the early embryonic heart development also remains unclear. In our study, it is suggested that the HIF-1α-mediated enhancement of glycolysis with activation of the pentose phosphate pathway, potentially leading to antioxidant defense and nucleotide biosynthesis, covers the increased energy demand in the beating heart. And it is also suggested that heartbeat initiation can be induced by development of bundles of myofilaments with up-regulated proteins associated with myofibrillogensis, whereas sarcomeres are not required for the initial heartbeat.

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  • Analysis of mechanisms of heartbeat initiation in embryonic stage

    Grant number：22500365  2010 - 2012

    Japan Society for the Promotion of Science  Grants-in-Aid for Scientific Research Grant-in-Aid for Scientific Research (C)  Grant-in-Aid for Scientific Research (C)

    TOHSE Noritsugu, KOBAYASHI Takeshi, MADEA Sachiko, ICHISE Nobutoshi

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    Grant amount：\3900000 （ Direct Cost: \3000000 、 Indirect Cost：\900000 ）

    In early embryonic stage, rat heart primordium begins the heatbeating. In cardiomyocytes from the early primordium, calcium current was observed. The calcium current was activated in pacemaker potential, and may be related to automaticity of heart. During this embryonic stage, gene expression and construction of protein molecule for the calcium channel (Cav1.3) were observed. The Cav 1.3 channels may be determinant for initiation of heart beat.

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Teaching Experience

  • 解剖生理学III, IV

    2024 Institution：札幌看護医療専門学校

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  • 生態機能形態学II

    2021 Institution：札幌医科大学大学院

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    Level：Postgraduate 

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  • 細胞・器官生理学

    2019 Institution：札幌医科大学

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  • 生理学

    2017 Institution：吉田学園医療歯科専門学校

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  • 医学概論・医療総論３（地域滞在実習）

    2016 Institution：Sapporo Medical University

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  • 生理学

    2016 - 2020 Institution：日本医療大学

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  • 生理学

    2011 Institution：北海道リハビリテーション大学校

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  • PBLチュートリアル

    2010 Institution：札幌医科大学

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  • 生理学実習（腎機能）

    2009 Institution：札幌医科大学

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Social Activities

  • 知的財産の活用による社会貢献

    Role(s)： Lecturer

    室蘭市立室蘭看護専門学院  2008.1

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  • 大学の知財

    Role(s)： Lecturer

    北海道東海大学  2006.6

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  • 人に役立つ微生物たち

    Role(s)： Lecturer

    室蘭市立室蘭看護専門学院  2004.7

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