Organization
School of Medicine Department of Legal Medicine Lecturer
Title
Lecturer
External link
MIZUO Keisuke
Research Interests
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薬物依存
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アルコール
Research Areas
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Life Science / Pharmacology
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Life Science / Neuroscience-general
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Life Science / Pharmaceutical hygiene and biochemistry
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Life Science / Forensics medicine
Research History
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Sapporo Medical University 助教・医学部
2008.4
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東京理科大学総合研究機構 ポストドクトラル研究員
2007.4 - 2008.3
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Temple University School of Medicine Postdoctoral fellow
2004.4 - 2007.3
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星薬科大学大学院薬学研究科博士課程後期修了 博士 (薬学) 取得
2004.3
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星薬科大学大学院薬学研究科博士課程後期 大学院生
2001.4 - 2004.3
Professional Memberships
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日本神経科学学会
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日本アルコール・薬物医学会
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日本薬理学会
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International Society for Biomedical Research on Alcoholism
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Society for Neuroscience
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日本法医学会
Papers
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Maternal exposure to nanoparticulate titanium dioxide during the prenatal period alters gene expression related to brain development in the mouse Reviewed
Midori Shimizu, Hitoshi Tainaka, Taro Oba, Keisuke Mizuo, Masakazu Umezawa, Ken Takeda
PARTICLE AND FIBRE TOXICOLOGY 6 20 2009.7
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Effect of prenatal exposure to diesel exhaust on dopaminergic system in mice Reviewed
Satoshi Yokota, Keisuke Mizuo, Nozomu Moriya, Shigeru Oshio, Isamu Sugawara, Ken Takeda
NEUROSCIENCE LETTERS 449 ( 1 ) 38 - 41 2009.1
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Changes in central dopaminergic systems and morphine reward by prenatal and neonatal exposure to bisphenol-A in mice: evidence for the importance of exposure period Reviewed
Minoru Narita, Kazuya Miyagawa, Keisuke Mizuo, Takuya Yoshida, Tsutomu Suzuki
ADDICTION BIOLOGY 12 ( 2 ) 167 - 172 2007.6
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Smooth muscle-associated protein 8: Distribution and biological activity in the rat brain Reviewed
G. Cristina Brailoiu, Siok L. Dun, Keisuke Mizuo, Eugen Brailoiu, Jun Yang, Jaw Kang Chang, Nae J. Dun
JOURNAL OF NEUROSCIENCE RESEARCH 85 ( 8 ) 1789 - 1796 2007.6
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Distribution and characterization of estrogen receptor G protein-coupled receptor 30 in the rat central nervous system Reviewed
Eugen Brailoiu, Siok L. Dun, G. Cristina Brailoiu, Keisuke Mizuo, Larry A. Sklar, Tudor I. Oprea, Eric R. Prossnitz, Nae J. Dun
JOURNAL OF ENDOCRINOLOGY 193 ( 2 ) 311 - 321 2007.5
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Prenatal and neonatal exposure to low-dose of bisphenol-A enhance the morphine-induced hyperlocomotion and rewarding effect Reviewed
M Narita, K Miyagawa, K Mizuo, T Yoshida, T Suzuki
NEUROSCIENCE LETTERS 402 ( 3 ) 249 - 252 2006.7
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Exposure to bisphenol-A affects the rewarding system in mice Reviewed
Tsutomu Suzuki, Keisuke Mizuo, Kazuya Miyagawa, Minoru Narita
Japanese Journal of Neuropsychopharmacology 25 ( 3 ) 125 - 128 2005.7
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Neuropeptide B immunoreactivity in the central nervous system of the rat Reviewed
SL Dun, GC Brailoiu, K Mizuo, J Yang, JK Chang, NJ Dun
BRAIN RESEARCH 1045 ( 1-2 ) 157 - 163 2005.5
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The functional change in the 5-HT1A receptor induced by stress and the role of the 5-HT1A receptor in neuroprotection Reviewed
Minoru Narita, Kazuya Miyagawa, Michiko Narita, Keisuke Mizuo, Mayumi Miyatake, Tsutomu Suzuki
Japanese Journal of Neuropsychopharmacology 25 ( 2 ) 91 - 104 2005.4
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Functional changes in dopamine D3 receptors by prenatal and neonatal exposure to an endocrine disruptor bisphenol-A in mice Reviewed
K Mizuo, M Narita, T Yoshida, M Narita, T Suzuki
ADDICTION BIOLOGY 9 ( 1 ) 19 - 25 2004.3
MISC
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エタノールが脂肪酸代謝に及ぼす影響
西谷陽子, 水尾圭祐, 片田竜一, 舘田健児, 渡邊智, 松本博志
日本アルコール・薬物医学会雑誌 = Japanese journal of alcohol studies & drug dependence 44 ( 4 ) 390 - 391 2009.8
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エタノール急性投与による脳におけるマイクロRNAの発現変動
水尾圭祐, 西谷陽子, 片田竜一, 渡邊智, 松本博志
日本アルコール・薬物医学会雑誌 = Japanese journal of alcohol studies & drug dependence 44 ( 4 ) 430 - 431 2009.8
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抗酸化剤はアルコール摂取後における脳挫傷の予後を改善させる
片田竜一, 西谷陽子, 今林貴代美, 水尾圭祐, 渡邊智, 松本博志
日本アルコール・薬物医学会雑誌 = Japanese journal of alcohol studies & drug dependence 43 ( 4 ) 540 - 542 2008.8
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アルコールの脳挫傷後脳浮腫に及ぼす影響
片田竜一, 西谷陽子, 今林貴代美, 水尾圭祐, 渡邊智, 松本博志
日本アルコール・薬物医学会雑誌 = Japanese journal of alcohol studies & drug dependence 43 ( 4 ) 474 - 476 2008.8
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Morphine 誘発報酬効果に関与する候補遺伝子の探索
水尾圭祐, 成田年, 松本博志, 鈴木勉
日本アルコール・薬物医学会雑誌 = Japanese journal of alcohol studies & drug dependence 43 ( 4 ) 418 - 419 2008.8
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Determination of the candidate genes for the psychological dependence
MIZUO Keisuke, NARITA Minoru, MATSUMOTO Hiroshi, SUZUKI Tsutomu
43 ( 4 ) 556 - 557 2008.8
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Change in μ-opioid receptors on the development of sensitization to Morphine-induced hyperlocomotion
NARITA Minoru, TAKIMOTO Atsushi, SOHMA Hitoshi, YAJIMA Yoshinori, MIZUNO Keisuke, KURORKI Yoshio, SUZUKI Tsutomu
21 ( 2 ) 55 - 61 2001.4
Presentations
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Prenatal exposure to titanium dioxide nanoparticles alters brain monoamine concentration in mice International conference
Keisuke Mizuo, Yuta Takahashi, Ken Takeda
Neuroscience 2009 2009.10
Awards
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奨励賞
2003 ニコチン・薬物依存研究フォーラム
水尾圭祐
Research Projects
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Molecular mechanisms of ethanol dependence and relapse-role in the brain microRNA
Grant number：21790611 2009
Japan Society for the Promotion of Science Grants-in-Aid for Scientific Research Grant-in-Aid for Young Scientists (B)
MIZUO Keisuke
Grant type：Competitive
Prolonged ethanol intake leads to the development of ethanol dependence. Although a lot of study suggested several candidates, certain mechanism of ethanol action is still unclear. Here we show that acute ethanol administration increased the expression of microRNA in mouse brain at 12 hours after administration. We observed that the acute ethanol administration significantly increased the levels of acetylated histone H3 in nucleus accumbens, ventral tegmental area and amygdala. The expression of miR-124 was significantly increased in limbic forebrain and lower midbrain following chronic treatment of ethanol. These findings suggest that chronic ethanol consumption increase the microRNA expression via histone acetylation, resulting in development of ethanol dependence.