Updated on 2025/08/22

写真a

 
ISHII Takao
 
Organization
School of Health Science Department of Occupational Therapy Second Division of Occupational Therapy Professor
Title
Professor
External link

Research Interests

  • 気分障害

  • 慢性疼痛

  • コンサルテーション・リエゾン精神医学

  • 精神薬理学

  • 精神腫瘍学

Research Areas

  • Life Science / Psychiatry

Research History

  • Sapporo Medical University   School of Health Sciences Department of Occupational Therapy   Professor

    2022.7

      More details

Papers

  • Association between occupational participation and depressive symptoms among middle-aged adults: A cross-sectional study in Hokkaido, Japan. International journal

    Kazuki Yokoyama, Kiyotaka Shimada, Takafumi Morimoto, Takao Ishii, Nozomu Ikeda

    Hong Kong journal of occupational therapy : HKJOT   37 ( 2 )   63 - 71   2024.12

     More details

    Language:English   Publishing type:Research paper (scientific journal)  

    AIM: This study aimed to investigate the association between occupational participation and depressive symptoms among middle-aged adults in Hokkaido, Japan. METHODS: Community-dwelling adults aged 40-64 years were recruited using snowball sampling, and 165 participants who returned the questionnaires and met the selection criteria were included in the analysis. Depressive symptoms were assessed using the Center for Epidemiologic Studies Depression (CES-D) scale. Occupational participation, including three domains (leisure, productivity, and self-care) and three aspects (occupational control, occupational balance, and satisfaction of performance), was assessed using Self-completed Occupational Performance Index (SOPI) questionnaire. RESULTS: Multivariate-adjusted regression analysis revealed that depressive symptoms were associated with lower occupational participation in the productivity domain (β = -0.34, p < .001), whereas analysis of each aspect of the SOPI showed a significant association of depressive symptoms with lower occupational control in productivity domain (β = -0.33, p < .001), occupational balance in productivity domain (β = -0.25, p < .001), and satisfaction with performance in leisure domain (β = -0.16, p = .045) and productivity domain (β = -0.35, p < .001). CONCLUSION: Depressive symptoms was significantly associated with low occupational participation in productivity domain in middle-aged adults. In the domains of leisure and self-care, significant associations were found only between depression symptoms and satisfaction of performance. Occupational therapy interventions for middle-aged adults targeting the maintenance and improvement of participation in productive activities may help preventing depressive symptoms.

    DOI: 10.1177/15691861241259527

    PubMed

    researchmap

  • コンサルテーション・リエゾン精神医学における作業療法士の実践についてのスコーピングレビュー

    森元 隆文, 島田 清貴, 石井 貴男

    作業療法の実践と科学   6 ( 4 )   106 - 116   2024.11

  • Relationship Between Social Networking Service Addiction and Occupational Dysfunction in Young Adults. International journal

    Takafumi Morimoto, Tsukasa Murakami, Tsutomu Sasaki, Kazuki Yokoyama, Takao Ishii, Nozomu Ikeda

    OTJR : occupation, participation and health   15394492241282790 - 15394492241282790   2024.9

     More details

    Language:English   Publishing type:Research paper (scientific journal)  

    Social networking services (SNSs) are useful tools; however, problematic use leads to mental health problems. This study aimed to examine whether SNS addiction is associated with occupational dysfunction while considering the effects of depression. This cross-sectional study included 268 undergraduates who responded to the questionnaire on the frequency and time of SNS use, the Center for Epidemiologic Studies Depression Scale (CES-D), SNS-X scale, and the Classification and Assessment of Occupational Dysfunction (CAOD). Hierarchical multiple regression analysis showed effect of the SNS-X score for Instagram was significant (β = 0.174, p = .001) adjusted by the CES-D total score. However, the effect of frequency and time of SNS use were not significant. This suggests that SNS addiction, and not SNS use, is a factor associated with occupational dysfunction that should be emphasized and depression.

    DOI: 10.1177/15394492241282790

    PubMed

    researchmap

  • 【救命救急センターに搬送される自殺企図者に対する精神科医の役割】自殺企図で救命救急センターに搬送される重症患者の臨床的特徴と対応

    石井 貴男, 佐野 智章, 大江 開, 河西 千秋

    精神神経学雑誌   125 ( 10 )   876 - 882   2023.10

     More details

    Language:Japanese   Publisher:(公社)日本精神神経学会  

    Ichushi

    researchmap

  • Reduced sociability in a prenatal immune activation model: Modulation by a chronic blonanserin treatment through the amygdala-hippocampal axis. International journal

    Kenta Deriha, Eri Hashimoto, Wataru Ukai, Francesca Marchisella, Emi Nishimura, Hanako Hashiguchi, Masaya Tayama, Takao Ishii, Marco A Riva, Chiaki Kawanishi

    Journal of psychiatric research   164   209 - 220   2023.8

     More details

    Language:English   Publishing type:Research paper (scientific journal)  

    The environmental disturbances in a critical neurodevelopmental period exert organizational effects on brain intrinsic plasticity including excitatory and inhibitory (E/I) neurotransmission those can cause the onset of psychiatric illness. We previously reported that treatment of neural precursor cells with N-methyl-D-aspartate (NMDA) receptor antagonist MK-801 induced reduction of GABAergic interneuron differentiation, and these changes recovered by atypical antipsychotic blonanserin treatment in vitro. However, it remains unclear how this treatment affects neural circuit changes in hippocampus and amygdala, which might contribute to the prevention of onset process of schizophrenia. To elucidate the pathogenic/preventive mechanisms underlying prenatal environmental adversity-induced schizophrenia in more detail, we administered poly (I:C) followed by antipsychotics and examined alterations in social/cognitive behaviors, GABA/glutamate-related gene expressions with cell density and E/I ratio, and brain-derived neurotrophic factor (Bdnf) transcript levels, particularly in limbic areas. Treatment with antipsychotic blonanserin ameliorated impaired social/cognitive behaviors and increased parvalbumin (PV)-positive (+) cell density and its mRNA levels as well as Bdnf with long 3'UTR mRNA levels, particularly in the dorsal hippocampus, in rats exposed to maternal immune activation (MIA). Low dose of blonanserin and haloperidol altered GABA and glutamate-related mRNA levels, the E/I ratio, and Bdnf long 3'UTR mRNA levels in the ventral hippocampus and amygdala, but did not attenuate behavioral impairments. These results strongly implicate changes in PV expression, PV(+) GABAergic interneuron density, and Bdnf long 3'UTR expression levels, particularly in the dorsal hippocampus, in the pathophysiology and treatment responses of MIA-induced schizophrenia and highlight the therapeutic potential of blonanserin for developmental stress-related schizophrenia.

    DOI: 10.1016/j.jpsychires.2023.06.014

    PubMed

    researchmap

  • Implementations of an evidence‐based assertive case management intervention for suicide attempters: Post‐ACTION‐J Study (PACS) International journal

    Takao Ishii, Naohiro Yonemoto, Yasushi Otaka, Kazuya Okamura, Noa Tsujii, Kotaro Otsuka, Reiji Yoshimura, Toshihiko Kinoshita, Daisuke Fujisawa, Hirokazu Tachikawa, Mitsuhiko Yamada, Yusuke Tsuyama, Satoshi Hashimoto, Chiaki Kawanishi

    Psychiatry and Clinical Neurosciences Reports   2 ( 2 )   e106   2023.6

     More details

    Language:English   Publishing type:Research paper (scientific journal)  

    AIM: An assertive case management intervention program, ACTION-J, proved effective for preventing suicide attempters from reattempting suicide within 6 months. The ACTION-J randomized trial was conducted as part of the "National Strategic Research Projects." The program has been covered by the national medical payment system of Japan since 2016. The aim of the Post-ACTION-J Study (PACS) was to examine the current implementation status of assertive case management in a real-world clinical setting. METHODS: PACS was a prospective, multicenter registry cohort study. The participants were suicide attempters admitted to the emergency departments of 10 participating medical facilities from October 2016 to September 2018. The assertive case management intervention developed by the ACTION-J Study was offered to all patients, and the primary outcome was the duration and frequency of use of the intervention at 6 months. RESULTS: A total of 1159 patients were admitted to emergency departments after a suicide attempt during the study period, 144 of whom were included in our analysis. The proportion of participants who received the intervention for 6 months was 72.2% (104/144), and 63.9% (92/144) of the patients completed ≥7 case management interviews within 6 months. CONCLUSION: The findings of this study indicate successful implementation of an assertive case management intervention program based on the ACTION-J Study in a real-world clinical setting, following its integration with the national medical payment scheme in Japan. The study provided the useful information that could improve the implementation of assertive case management interventions in future.

    DOI: 10.1002/pcn5.106

    PubMed

    researchmap

  • Identification of epigenetically active L1 promoters in the human brain and their relationship with psychiatric disorders. International journal

    Risa Watanabe, Yutaka Nakachi, Hikari Matsubara, Junko Ueda, Takao Ishii, Wataru Ukai, Eri Hashimoto, Kiyoto Kasai, Siro Simizu, Tadafumi Kato, Miki Bundo, Kazuya Iwamoto

    Neuroscience research   195   37 - 51   2023.5

     More details

    Language:English   Publishing type:Research paper (scientific journal)  

    Long interspersed nuclear element-1 (LINE-1, L1) affects the transcriptome landscape in multiple ways. Promoter activity within its 5'UTR plays a critical role in regulating diverse L1 activities. However, the epigenetic status of L1 promoters in adult brain cells and their relationship with psychiatric disorders remain poorly understood. Here, we examined DNA methylation and hydroxymethylation of the full-length L1s in neurons and nonneurons and identified "epigenetically active" L1s. Notably, some of epigenetically active L1s were retrotransposition competent, which even had chimeric transcripts from the antisense promoters at their 5'UTRs. We also identified differentially methylated L1s in the prefrontal cortices of patients with psychiatric disorders. In nonneurons of bipolar disorder patients, one L1 was significantly hypomethylated and showed an inverse correlation with the expression level of the overlapping gene NREP. Finally, we observed that altered DNA methylation levels of L1 in patients with psychiatric disorders were not affected by the surrounding genomic regions but originated from the L1 sequences. These results suggested that altered epigenetic regulation of the L1 5'UTR in the brain was involved in the pathophysiology of psychiatric disorders.

    DOI: 10.1016/j.neures.2023.05.001

    PubMed

    researchmap

  • 統合失調症の社会性認知機能障害の脳基盤解析 Glutamate/GABAニューロンバランスメカニズムからの検討

    出利葉 健太, 鵜飼 渉, Riva Marco, 西村 恵美, 橋本 恵理, 木川 昌康, 橋口 華子, 古瀬 研吾, 田山 真矢, 村山 友規, 石井 貴男, 河西 千秋

    日本神経精神薬理学会年会・日本生物学的精神医学会年会・日本精神薬学会総会・学術集会合同年会プログラム・抄録集   50回・42回・4回   189 - 189   2020.8

     More details

    Language:Japanese   Publisher:日本神経精神薬理学会・日本生物学的精神医学会・日本精神薬学会  

    Ichushi

    researchmap

  • 胎生期免疫ストレス誘発統合失調症モデルの社会性行動とGABA作動性インターニューロン変化に関する研究

    橋本 恵理, 鵜飼 渉, 西村 恵美, 橋口 華子[辻野], 木川 昌康, 田山 真矢, 出利葉 健太, 廣瀬 奨真, 古瀬 研吾, 石井 貴男, 河西 千秋

    精神神経学雑誌   ( 2019特別号 )   S470 - S470   2019.6

     More details

    Language:Japanese   Publisher:(公社)日本精神神経学会  

    Ichushi

    researchmap

  • Antidepressant activities of escitalopram and blonanserin on prenatal and adolescent combined stress-induced depression model: Possible role of neurotrophic mechanism change in serum and nucleus accumbens. International journal

    Kengo Furuse, Wataru Ukai, Eri Hashimoto, Hanako Hashiguchi, Yoshiyasu Kigawa, Takao Ishii, Masaya Tayama, Kenta Deriha, Masaki Shiraishi, Chiaki Kawanishi

    Journal of affective disorders   247   97 - 104   2019.3

     More details

    Language:English   Publishing type:Research paper (scientific journal)  

    BACKGROUND: There has been number of studies suggesting experiences of adversity in early life interrelated subsequent brain development, however, neurobiological mechanisms confer risk for onset of psychiatric illness remains unclear. METHODS: In order to elucidate the pathogenic mechanisms underlying early life adversity-induced refractory depression in more detail, we administered corticosterone (CORT) to adolescent rats with or without prenatal ethanol exposure followed by an antidepressant or antipsychotic and examined alterations in depressive and social function behaviors and brain-derived neurotrophic factor (BDNF) levels in serum, the hippocampus, anterior cingulate cortex, and nucleus accumbens. RESULTS: The combined stress exposure of prenatal ethanol and adolescent CORT prolonged immobility times in the forced swim test (FST), and increased investigation times and numbers in the social interaction test (SIT). A treatment with escitalopram reversed depression-like behavior accompanied by reductions in BDNF levels in serum and the nucleus accumbens, while a treatment with blonanserin ameliorated abnormal social interaction behavior with reductions in serum BDNF levels. LIMITATIONS: Further studies are needed to clarify the clinical evinces responding to these results, and many questions remain regarding the mechanisms by which refractory depression and antidepressant/antipsychotic treatments cause changes in serum and brain regional BDNF levels. CONCLUSION: These results strongly implicate changes in BDNF levels in serum and the nucleus accumbens in the pathophysiology and treatment of early life combined stress-induced depression and highlight the therapeutic potential of escitalopram and new generation antipsychotic blonanserin for treatment-resistant refractory depression.

    DOI: 10.1016/j.jad.2019.01.007

    PubMed

    researchmap

  • Protocol for a prospective multicentre registry cohort study on suicide attempters given the assertive case management intervention after admission to an emergency department in Japan: post-ACTION-J Study (PACS). International journal

    Chiaki Kawanishi, Takao Ishii, Naohiro Yonemoto, Mitsuhiko Yamada, Hirokazu Tachikawa, Toshifumi Kishimoto, Noa Tsujii, Satoshi Hashimoto, Toshihiko Kinoshita, Masaru Mimura, Yoshiro Okubo, Kotaro Otsuka, Reiji Yoshimura

    BMJ open   8 ( 9 )   e020517   2018.10

     More details

    Language:English   Publishing type:Research paper (scientific journal)  

    INTRODUCTION: Suicide attempt is the most important risk factor for later suicide. A randomised-controlled, multicentre trial of postsuicide attempt case management for the prevention of further suicide attempts in Japan, named ACTION-J, has established effective interventions for prevention of suicide reattempts. The ACTION-J assertive case management intervention programme was adopted by the Japanese Ministry of Health, Labour and Welfare in 2016, when medical fees were revised. This nationwide programme is provided to patients who attempt suicide and who are admitted to emergency departments in Japan.The aim of the present study is to examine the current implementation status of the ACTION-J programme. The present study also aims to clarify which patients' and hospitals' factors affect the implementation of the programme. METHODS AND ANALYSIS: This is a prospective, multicentre, patient registry cohort study. Participants will be suicide attempters admitted to the emergency departments of medical facilities with both psychiatry and emergency departments. The assertive case management programme will be delivered to participants by a case manager for up to 24 weeks, based on psychiatric diagnoses, social risks and patient needs. The core feature of the programme is to encourage patients to participate in psychiatric treatment.The primary outcome will be the proportion of patients still participating in the case management intervention at 24 weeks after registration. The secondary outcomes will include measures of the fidelity of the case management intervention. The fidelity will be evaluated using a fidelity assessment manual developed by the study group. ETHICS AND DISSEMINATION: This observational study has been approved by the ethics board of Sapporo Medical University. Enrolment began in October 2016 and will continue until December 2018. Dissemination plans include presentations at scientific conferences and scientific publications. TRIAL REGISTRATION: UMIN000024474.

    DOI: 10.1136/bmjopen-2017-020517

    PubMed

    researchmap

  • Psychiatric Consultations at an Emergency Department in a Metropolitan University Hospital in Northern Japan. International journal

    Masaki Shiraishi, Takao Ishii, Yoshiyasu Kigawa, Masaya Tayama, Keisuke Inoue, Kenji Narita, Masaru Tateno, Chiaki Kawanishi

    Psychiatry investigation   15 ( 7 )   739 - 742   2018.7

     More details

    Language:English   Publishing type:Research paper (scientific journal)  

    Many patients with mental disorders visit emergency departments (EDs). However, the majority of these patients do not receive psychiatric assessment. In the present study, we investigated the detailed proportion of patients with mental disorders visiting an urban ED in the largest northern city in Japan. A retrospective chart review study was performed at a University Hospital from January 2012 to December 2015. The reasons for psychiatric consultations made by ED staff, and the primary psychiatric diagnoses were investigated. Among all living patients, 20% of them received consultations. The most common reason for consultation was suicide attempt followed by agitation or insomnia. Of all diagnoses, organic mental disorder was the most frequent and the mean age was significantly higher than the other diagnostic groups. Our study indicated that the frequency of psychiatric consultation was high. This indicates the high demand for mental health services at the ED. A thorough psychiatric assessment can provide adequate psychiatric services to acute patients; thereby possibly preventing suicide attempters from later actually dying by suicide.

    DOI: 10.30773/pi.2018.04.04

    PubMed

    researchmap

  • Identification of somatic mutations in postmortem human brains by whole genome sequencing and their implications for psychiatric disorders. International journal

    Masaki Nishioka, Miki Bundo, Junko Ueda, Fumiki Katsuoka, Yukuto Sato, Yoko Kuroki, Takao Ishii, Wataru Ukai, Shigeo Murayama, Eri Hashimoto, Masao Nagasaki, Jun Yasuda, Kiyoto Kasai, Tadafumi Kato, Kazuya Iwamoto

    Psychiatry and clinical neurosciences   72 ( 4 )   280 - 294   2018.4

     More details

    Language:English   Publishing type:Research paper (scientific journal)  

    AIM: Somatic mutations in the human brain are hypothesized to contribute to the functional diversity of brain cells as well as the pathophysiology of neuropsychiatric diseases. However, there are still few reports on somatic mutations in non-neoplastic human brain tissues. This study attempted to unveil the landscape of somatic mutations in the human brain. METHODS: We explored the landscape of somatic mutations in human brain tissues derived from three individuals with no neuropsychiatric diseases by whole-genome deep sequencing at a depth of around 100. The candidate mutations underwent multi-layered filtering, and were validated by ultra-deep target amplicon sequencing at a depth of around 200 000. RESULTS: Thirty-one somatic mutations were identified in the human brain, demonstrating the utility of whole-genome sequencing of bulk brain tissue. The mutations were enriched in neuron-expressed genes, and two-thirds of the identified somatic single nucleotide variants in the brain tissues were cytosine-to-thymine transitions, half of which were in CpG dinucleotides. CONCLUSION: Our developed filtering and validation approaches will be useful to identify somatic mutations in the human brain. The vulnerability of neuron-expressed genes to mutational events suggests their potential relevance to neuropsychiatric diseases.

    DOI: 10.1111/pcn.12632

    PubMed

    researchmap

  • The essence of deep learning : what is a deep communication and where is its responsive area in the brain?

    鵜飼 渉, 辻野 華子, 杉村 政樹, 木川 昌康, 田山 真矢, 石井 貴男, 古瀬 研吾, 廣瀬 奨真, 橋本 恵理, 澤田 いずみ, 山本 武志, 白鳥 正典, 河西 千秋, 相馬 仁

    医療人育成センター紀要   9 ( 9 )   35 - 43   2018.3

     More details

    Language:Japanese   Publisher:札幌医科大学医療人育成センター  

    Ichushi

    researchmap

  • Retrospective study of Trazodone monotherapy compared with Ramelteon and Trazodone combination therapy for the management of delirium Reviewed

    Takao Ishii, Takafumi Morimoto, Masaki Shiraishi, Yoshiyasu Kigawa, Kenji Narita, Keisuke Inoue, Chiaki Kawanishi

    Journal of Psychiatry   21 ( 3 )   444   2018

     More details

    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.4172/2378-5756.1000444

    researchmap

  • Antipsychotics promote GABAergic interneuron genesis in the adult rat brain: Role of heat-shock protein production. International journal

    Hiroo Kaneta, Wataru Ukai, Hanako Tsujino, Kengo Furuse, Yoshiyasu Kigawa, Masaya Tayama, Takao Ishii, Eri Hashimoto, Chiaki Kawanishi

    Journal of psychiatric research   92   108 - 118   2017.9

     More details

    Language:English   Publishing type:Research paper (scientific journal)  

    Current antipsychotics reduce positive symptoms and reverse negative symptoms in conjunction with cognitive behavioral issues with the goal of restoring impaired occupational and social functioning. However, limited information is available on their influence on gliogenesis or their neurogenic properties in adult schizophrenia brains, particularly on GABAergic interneuron production. In the present study, we used young adult subventricular zone (SVZ)-derived progenitor cells expressing proteoglycan NG2 cultures to examine the oligodendrocyte and GABAergic interneuron genesis effects of several kinds of antipsychotics on changes in differentiation function induced by exposure to the NMDA receptor antagonist MK-801. We herein demonstrated that antipsychotics promoted or restored changes in the oligodendrocyte/GABAergic interneuron differentiation functions of NG2(+) cells induced by the exposure to MK-801, which was considered to be one of the drug-induced schizophrenia model. We also demonstrated that antipsychotics restored heat-shock protein (HSP) production in NG2(+) cells with differentiation impairment. The antipsychotics olanzapine, aripiprazole, and blonanserin, but not haloperidol increased HSP90 levels, which were reduced by the exposure to MK-801. Our results showed that antipsychotics, particularly those recently synthesized, exerted similar GABAergic interneuron genesis effects on NG2(+) neuronal/glial progenitor cells in the adult rat brain by increasing cellular HSP production, and also suggest that HSP90 may play a crucial role in the pathophysiology of schizophrenia and is a key target for next drug development.

    DOI: 10.1016/j.jpsychires.2017.03.008

    PubMed

    researchmap

  • The usefulness of combined brain perfusion single-photon emission computed tomography, Dopamine-transporter single-photon emission computed tomography, and 123 I-metaiodobenzylguanidine myocardial scintigraphy for the diagnosis of dementia with Lewy bodies. International journal

    Seiju Kobayashi, Kanae Makino, Shigeki Hatakeyama, Takao Ishii, Masaru Tateno, Tomo Iwamoto, Hanako Tsujino, Kazuhito Kawasaki, Kouhei Mikuni, Wataru Ukai, Tomonori Murayama, Eri Hashimoto, Kumiko Utsumi, Chiaki Kawanishi

    Psychogeriatrics : the official journal of the Japanese Psychogeriatric Society   17 ( 4 )   247 - 255   2017.7

     More details

    Language:English   Publishing type:Research paper (scientific journal)  

    BACKGROUND: Current diagnostic criteria recommend neuroimaging as a diagnostic support tool for the clinical diagnosis of dementia with Lewy bodies (DLB). Because DLB causes characteristic impairments and disabilities, such as neuroleptic hypersensitivity, which may significantly increase morbidity and mortality, its prompt and correct diagnosis is very important. The aim of this study was to evaluate the extent to which diagnostic accuracy can be increased by using different combinations of brain perfusion single-photon emission computed tomography (bp-SPECT), 123 I-metaiodobenzylguanidine myocardial scintigraphy (MIBG scintigraphy), and DAT-SPECT. Taking finances and patient burden into consideration, we compared the tests to determine priority. METHODS: Thirty-four patients with probable DLB (75.0 ± 8.3 years old; 14 men, 20 women) underwent bp-SPECT, MIBG scintigraphy, and DAT-SPECT. RESULTS: Our comparison of three functional imaging techniques indicated that MIBG scintigraphy (79%) and Dopamine-transporter (DAT) SPECT (79%) had better sensitivity for characteristic abnormalities in DLB than bp-SPECT (53%). The combination of the three modalities could increase sensitivity for diagnosis of DLB to 100%. Additionally, the ratio of patients with rapid eye movement sleep behaviour disorder was significantly higher in the positive finding group on MIBG scintigraphy than in the negative finding group. CONCLUSIONS: In terms of stand-alone diagnostic means, priority should be placed on MIBG scintigraphy or DAT-SPECT for the diagnosis of DLB. However, our results suggest that the combination of bp-SPECT, MIBG scintigraphy, and DAT-SPECT increased the accuracy of the clinical diagnosis of DLB.

    DOI: 10.1111/psyg.12227

    PubMed

    researchmap

  • A large-scale survey of inpatient suicides: comparison between medical and psychiatric settings. International journal

    Keisuke Inoue, Chiaki Kawanishi, Kotaro Otsuka, Yoshinori Cho, Masaki Shiraishi, Takao Ishii, Hideki Onishi, Yoshio Hirayasu

    Psychiatry research   250   155 - 158   2017.4

     More details

    Language:English   Publishing type:Research paper (scientific journal)  

    Suicide is one of the common severe accidents occurring in hospitals. This study aimed to investigate inpatient suicides simultaneously in medical and psychiatric settings in a large number of hospitals and to examine the prevalence of common suicide risk factors, related symptoms in inpatients who had died by suicide and the differences in inpatient suicides between both settings. We conducted a survey of hospitals in Japan that belonged to the nationwide standard-setting and accrediting body. The questionnaire covered the: 1) presence or absence of inpatient suicides in each hospital from 2012 to 2015; 2) number of inpatient suicides; 3) method, location, and timing of inpatient suicides; and 4) characteristics of inpatients who died by suicide. In total, 529 hospitals reported 262 inpatient suicides during the 3-year period: 131 were in medical settings and 131 were in psychiatric settings. The prevalence of common suicide risk factors was frequent in inpatient suicides. Inpatients had characteristics and suicide risk factors specific to those settings such as worsening of physical health in medical settings. Therefore, recognizing common suicide risk factors and understanding differences in inpatient suicides between both settings are important to prevent inpatient suicides.

    DOI: 10.1016/j.psychres.2017.01.076

    PubMed

    researchmap

  • Epigenetic status of LINE-1 promoters in neurons and non-neurons Reviewed

    Risa Watanabe, Miki Bundo, Eri Hashimoto, Takao Ishii, Kazuya Iwamoto, Kiyoto Kasai, Tadafumi Kato, Yui Murata, Masaki Nishioka, Yutaka Sawai, Siro Simizu, Junko Ueda, Wataru Ukai

    INTERNATIONAL JOURNAL OF NEUROPSYCHOPHARMACOLOGY   19   230 - 230   2016.6

     More details

    Language:English  

    Web of Science

    researchmap

  • Pathological analysis of refractory depression using fetal alcohol and adolescent corticosterone double stress model Reviewed

    Kengo Furuse, Hanako Tsujino, Yoshiyasu Kigawa, Masaya Tayama, Wataru Ukai, Takao Ishii, Tomo Iwamoto, Masaki Shiraishi, Seiju Kobayashi, Eri Hashimoto, Chiaki Kawanishi

    INTERNATIONAL JOURNAL OF NEUROPSYCHOPHARMACOLOGY   19   119 - 120   2016.6

     More details

    Language:English  

    Web of Science

    researchmap

  • アルコール性障害が関与する難治性うつ病の病態基盤 血中・脳中BDNF値の変動解析から

    古瀬 研吾, 木川 昌康, 辻野 華子, 石井 貴男, 田山 真矢, 鵜飼 渉, 橋本 恵理, 齋藤 利和, 河西 千秋

    アルコールと医学生物学   34   29 - 30   2016.6

     More details

    Language:Japanese   Publisher:(株)響文社  

    Ichushi

    researchmap

  • The effect of APOE ϵ4 allele on brain perfusion SPECT in late onset Alzheimer's disease by an automated program, 3DSRT Reviewed

    Seiju Kobayashi, Takao Ishii, Masaru Tateno, Hitoshi Sohma, Yasuo Kokai, Yoichi M. Ito, Tomo Iwamoto, Kengo Furuse, Hanako Tsujino, Hidetoshi Morii, Wataru Ukai, Eri Hashimoto, Kumiko Utsumi, Chiaki Kawanishi

    Neuropsychiatry   6 ( 2 )   55 - 63   2016

     More details

    Language:English   Publishing type:Research paper (scientific journal)   Publisher:Future Medicine Ltd.  

    DOI: 10.4172/Neuropsychiatry.1000119

    researchmap

  • Stem cell therapy: a new approach to the treatment of refractory depression. International journal

    Yoshiyasu Kigawa, Eri Hashimoto, Wataru Ukai, Takao Ishii, Kengo Furuse, Hanako Tsujino, Tomohiro Shirasaka, Toshikazu Saito

    Journal of neural transmission (Vienna, Austria : 1996)   121 ( 10 )   1221 - 32   2014.10

     More details

    Language:English   Publishing type:Research paper (scientific journal)  

    To better understand the relationship of repeated exposure to adversity during early development as a risk factor for refractory depression, we exposed pregnant female rats to ethanol and the resulting pups to corticosterone during adolescence. A stressful forced swim test was then used to induce depression-like behavior. The adolescent rat brains were examined for the possible therapeutic benefit of a combination of sertraline, an antidepressant, and neural stem cells (NSCs) complexed with atelocollagen in relation to the level of GABAergic interneuron and synaptic protein density in different brain regions. The combined exposures of prenatal and adolescent stress resulted in a reduction in parvalbumin (PV)-positive phenotype of GABAergic interneurons and reduced postsynaptic density protein 95 (PSD-95) levels in the anterior cingulate cortex, amygdala, and hippocampus. Treatments with sertraline and NSCs reversed the reductions in PV-positive cells and PSD-95 levels. Furthermore, the combined treatment of sertraline and NSCs resulted in reduced depressive-like behaviors. These experiments underscore a potentially important role for synaptic remodeling and GABAergic interneuron genesis in the treatment of refractory depression and highlight the therapeutic potential of stem cell and pharmacological combination treatments for refractory depression.

    DOI: 10.1007/s00702-014-1194-2

    PubMed

    researchmap

  • Characteristics of attempted suicide by patients with schizophrenia compared with those with mood disorders: a case-controlled study in northern Japan. International journal

    Takao Ishii, Eri Hashimoto, Wataru Ukai, Yohei Kakutani, Ryuji Sasaki, Toshikazu Saito

    PloS one   9 ( 5 )   e96272   2014

     More details

    Language:English   Publishing type:Research paper (scientific journal)  

    Recent reports suggest a lifetime suicide risk for schizophrenia patients of approximately 5%. This figure is significantly higher than the general population suicide risk consequently, detection of those at risk is clinically important. This study was undertaken to define the characteristics of suicide attempts by schizophrenia patients compared with attempts by patients with mood disorders. All patients were diagnosed using the ICD-10 criteria. The study population comprised 65 patients with F2 disorders (schizophrenia, schizotypal and delusional disorders), i.e., "the F2 group", and 94 patients with F3 disorders (mood disorders), i.e., "the F3 group", who presented in the clinical setting of consultation-liaison psychiatry. The F2 group had a significantly younger mean age and significantly higher ratios of 'past/present psychiatric treatment' and 'more than 3 months interruption of psychiatric treatment'. In contrast, the ratios of 'physical disorder comorbidity', 'alcohol intake at suicide attempt' and 'suicide note left behind' were significantly higher in the F3 group. The F2 group attempted suicide by significantly more serious methods. Furthermore, 'hallucination-delusion' was the most prevalent motive in the F2 group and was the only factor that showed a significant association with the seriousness of the method of suicide attempt (OR = 3.36, 95% CI: 1.05-11.33).

    DOI: 10.1371/journal.pone.0096272

    PubMed

    researchmap

  • Effects of Ethanol and Antidepressant on the Platelet BDNF Release Function in the Peripheral Blood: Implication in the Pathogenesis of Psychiatric Disease Reviewed

    Toshikazu Saito, Eri Hashimoto, Wataru Ukai, Takao Ishii, Yoshiyasu Kigawa, Kengo Furuse, Hanako Tsujino

    NEUROPSYCHOPHARMACOLOGY   38   S549 - S549   2013.12

     More details

    Language:English  

    Web of Science

    researchmap

  • Effects of atelocollagen on neural stem cell function and its migrating capacity into brain in psychiatric disease model. International journal

    Toshihiro Yoshinaga, Eri Hashimoto, Wataru Ukai, Takao Ishii, Tomohiro Shirasaka, Yoshiyasu Kigawa, Masaru Tateno, Hiroo Kaneta, Kimihiko Watanabe, Takeshi Igarashi, Seiju Kobayashi, Hitoshi Sohma, Tadafumi Kato, Toshikazu Saito

    Journal of neural transmission (Vienna, Austria : 1996)   120 ( 10 )   1491 - 8   2013.10

     More details

    Language:English   Publishing type:Research paper (scientific journal)  

    Stem cell therapy is well proposed as a potential method for the improvement of neurodegenerative damage in the brain. Among several different procedures to reach the cells into the injured lesion, the intravenous (IV) injection has benefit as a minimally invasive approach. However, for the brain disease, prompt development of the effective treatment way of cellular biodistribution of stem cells into the brain after IV injection is needed. Atelocollagen has been used as an adjunctive material in a gene, drug and cell delivery system because of its extremely low antigenicity and bioabsorbability to protect these transplants from intrabody environment. However, there is little work about the direct effect of atelocollagen on stem cells, we examined the functional change of survival, proliferation, migration and differentiation of cultured neural stem cells (NSCs) induced by atelocollagen in vitro. By 72-h treatment 0.01-0.05% atelocollagen showed no significant effects on survival, proliferation and migration of NSCs, while 0.03-0.05% atelocollagen induced significant reduction of neuronal differentiation and increase of astrocytic differentiation. Furthermore, IV treated NSCs complexed with atelocollagen (0.02%) could effectively migrate into the brain rather than NSC treated alone using chronic alcohol binge model rat. These experiments suggested that high dose of atelocollagen exerts direct influence on NSC function but under 0.03% of atelocollagen induces beneficial effect on regenerative approach of IV administration of NSCs for CNS disease.

    DOI: 10.1007/s00702-013-1010-4

    PubMed

    researchmap

  • 抗うつ薬およびアルコールによる血小板からのBDNF遊離反応の変化

    石井 貴男, 鵜飼 渉, 橋本 恵理, 木川 昌康, 古瀬 研吾, 辻野 華子, 今井 智之, 吉永 敏弘, 齋藤 利和

    日本臨床精神神経薬理学会・日本神経精神薬理学会合同年会プログラム・抄録集   23回・43回   238 - 238   2013.10

     More details

    Language:Japanese   Publisher:日本臨床精神神経薬理学会・日本神経精神薬理学会  

    Ichushi

    researchmap

  • 【依存・乱用の今日的課題】アルコール関連問題の今日的課題

    齋藤 利和, 橋本 恵理, 石井 貴男

    臨床精神医学   42 ( 9 )   1079 - 1083   2013.9

     More details

    Language:Japanese   Publisher:(株)アークメディア  

    Ichushi

    researchmap

  • 気分障害とアルコール性脳障害の共通基盤 末梢血血小板からのBDNF遊離反応の解析から

    鵜飼 渉, 石井 貴男, 橋本 恵理, 木川 昌康, 古瀬 健吾, 辻野 華子, 今井 智之, 吉永 敏弘, 齋藤 利和

    日本アルコール・薬物医学会雑誌   48 ( 4 )   176 - 176   2013.8

     More details

    Language:Japanese   Publisher:(一社)日本アルコール・アディクション医学会  

    Ichushi

    J-GLOBAL

    researchmap

  • 【うつ病の亜型分類への展望-その2】アルコール性気分障害の臨床

    石井 貴男, 橋本 恵理, 齋藤 利和

    臨床精神医学   42 ( 8 )   1027 - 1034   2013.8

     More details

    Language:Japanese   Publisher:(株)アークメディア  

    Ichushi

    researchmap

  • アルコール・薬物依存症の治療標的因子を探る 精神疾患に対する神経幹細胞移植療法を用いた新しい治療法の可能性

    白坂 知彦, 鵜飼 渉, 木川 昌康, 吉永 敏弘, 石井 貴男, 橋本 恵理, 齋藤 利和

    日本アルコール・薬物医学会雑誌   48 ( 4 )   105 - 105   2013.8

     More details

    Language:Japanese   Publisher:(一社)日本アルコール・アディクション医学会  

    Ichushi

    researchmap

  • PROMISING THERAPY OF INTRAVENOUS NEURAL STEM CELL TRANSPLANTATION - A STRATEGY FOR FACILITATION OF NEURAL NETWORK AND BEHAVIOURAL RECOVERY Reviewed

    Tomohiro Shirasaka, Wataru Ukai, Eri Hashimoto, Toshihiro Yoshinaga, Takao Ishii, H. Kaneta, Toshikazu Saito

    AUSTRALIAN AND NEW ZEALAND JOURNAL OF PSYCHIATRY   47 ( S1 )   88 - 89   2013.5

     More details

    Language:English  

    Web of Science

    researchmap

  • Stem cell therapy: social recognition recovery in a FASD model Reviewed

    T. Shirasaka, E. Hashimoto, W. Ukai, T. Yoshinaga, T. Ishii, M. Tateno, T. Saito

    TRANSLATIONAL PSYCHIATRY   2   e188   2012.11

     More details

    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1038/tp.2012.111

    PubMed

    Web of Science

    researchmap

  • Promising therapy of intravenous neural stem cell transplantation - A strategy for facilitation of neural network and behavioral recovery Reviewed

    Tomohiro Shirasaka, Wataru Ukai, Eri Hashimoto, Toshihiro Yoshinaga, Takao Ishii, Hiroo Kaneta, Toshikazu Saito

    ASIA-PACIFIC PSYCHIATRY   4   125 - 126   2012.10

     More details

    Language:English  

    Web of Science

    researchmap

  • アルコール・薬物依存 基礎から臨床まで アルコールによる脳障害に対する新たな治療法の可能性を探る FASDモデルを用いた検討

    橋本 恵理, 白坂 知彦, 吉永 敏弘, 金田 博雄, 木川 昌康, 五十嵐 健史, 渡邊 公彦, 石井 貴男, 鵜飼 渉, 館農 勝, 齋藤 利和

    日本アルコール・薬物医学会雑誌   47 ( 4 )   103 - 103   2012.8

     More details

    Language:Japanese   Publisher:(一社)日本アルコール・アディクション医学会  

    Ichushi

    researchmap

  • A systems genetic analysis of alcohol drinking by mice, rats and men: influence of brain GABAergic transmission. International journal

    Laura M Saba, Beth Bennett, Paula L Hoffman, Kelsey Barcomb, Takao Ishii, Katerina Kechris, Boris Tabakoff

    Neuropharmacology   60 ( 7-8 )   1269 - 80   2011.6

     More details

    Language:English   Publishing type:Research paper (scientific journal)  

    Genetic influences on the predisposition to complex behavioral or physiological traits can reflect genetic polymorphisms that lead to altered gene product function, and/or variations in gene expression levels. We have explored quantitative variations in an animal's alcohol consumption, using a genetical genomic/phenomic approach. In our studies, gene expression is correlated with amount of alcohol consumed, and genomic regions that regulate the alcohol consumption behavior and the quantitative levels of gene expression (behavioral and expression quantitative trait loci [QTL]) are determined and used as a filter to identify candidate genes predisposing the behavior. We determined QTLs for alcohol consumption using the LXS panel of recombinant inbred mice. We then identified genes that were: 1) differentially expressed between five high and five low alcohol-consuming lines or strains of mice; and 2) were physically located in, or had an expression QTL (eQTL) within the alcohol consumption QTLs. Comparison of mRNA and protein levels in brains of high and low alcohol consuming mice led us to a bioinformatic examination of potential regulation by microRNAs of an identified candidate transcript, Gnb1 (G protein beta subunit 1). We combined our current analysis with our earlier work identifying candidate genes for the alcohol consumption trait in mice, rats and humans. Our overall analysis leads us to postulate that the activity of the GABAergic system, and in particular GABA release and GABA receptor trafficking and signaling, which involves G protein function, contributes significantly to genetic variation in the predisposition to varying levels of alcohol consumption. This article is part of a Special Issue entitled 'Trends in neuropharmacology: in memory of Erminio Costa'.

    DOI: 10.1016/j.neuropharm.2010.12.019

    PubMed

    researchmap

  • Effect of antidepressants on brain-derived neurotrophic factor (BDNF) release from platelets in the rats. International journal

    Kimihiko Watanabe, Eri Hashimoto, Wataru Ukai, Takao Ishii, Toshihiro Yoshinaga, Takafumi Ono, Masaru Tateno, Ippei Watanabe, Tomohiro Shirasaka, Satoshi Saito, Toshikazu Saito

    Progress in neuro-psychopharmacology & biological psychiatry   34 ( 8 )   1450 - 4   2010.12

     More details

    Language:English   Publishing type:Research paper (scientific journal)  

    Brain-derived neurotrophic factor (BDNF) belongs to the neurotrophin family, and enhances the growth and maintenance of several neuronal systems. In addition, BDNF may promote neurogenesis and protect against hippocampal volume loss in depressive disorders. Although first detected in brain, BDNF also exists in peripheral tissues and is mainly stored in platelets and circulates in blood. Recent reports indicate that serum BDNF levels in depressive patients are lower than in control subjects, and antidepressant treatment increases serum BDNF levels in responders. A single report suggests that decreased serum BDNF in major depression is related to mechanisms of platelet BDNF release; however, the mechanisms of changes in BDNF blood levels are still poorly understood. In the present study, we investigated the direct influence of antidepressants on BDNF release from platelets and their effects on serum levels. We used samples of washed platelets prepared from rat blood, and investigated the platelet BDNF release and serum BDNF concentration changes in response to adding antidepressants. We found that BDNF was dose-dependently released from platelets by direct treatment with various kinds of antidepressants in vitro, and serum BDNF concentration was also increased by intravenous antidepressant treatment. These results confirm that BDNF release from platelets is affected by antidepressants, which may relate to the circulating BDNF level change in peripheral blood. The response of BDNF release differs depending on the type and amount of antidepressants, making BDNF a serious candidate as a predictor of antidepressant treatment response.

    DOI: 10.1016/j.pnpbp.2010.07.036

    PubMed

    researchmap

  • The role of neural stem cells for in vitro models of schizophrenia: neuroprotection via Akt/ERK signal regulation. International journal

    Takafumi Ono, Eri Hashimoto, Wataru Ukai, Takao Ishii, Toshikazu Saito

    Schizophrenia research   122 ( 1-3 )   239 - 47   2010.9

     More details

    Language:English   Publishing type:Research paper (scientific journal)  

    Recent neuroimaging studies have revealed progressive morphological brain changes during the course of schizophrenia, and the neurotrophic and neurogenetic effects of atypical antipsychotics are believed to prevent or retard these brain volume reductions. In addition to drug-induced neural stem cell (NSC) activation, transplantation of exogenous NSCs has been proposed as a possible approach to repair the damaged brain in psychiatric disease. NSC transplantation embraces not only neuron replacement but also enhanced neuroprotection of existing neurons with the goal of restoring the impaired brain. However, little is known about the cell-cell interactions of exogenous NSCs with existing neurons, or about their neuroprotective actions especially in psychiatric diseases. In the present study, we used cortical neuron cultures to examine the neurotrophism and neuroprotection of exogenous NSCs against the neuronal damage induced by exposure to the NMDA receptor antagonist, MK-801. We also investigated their role in serum/nutrient deprivation stress. The exogenous NSCs exerted neuroprotective effects against both types of apoptotic injuries considered as in vitro schizophrenic disease models. Exogenous NSCs also altered cellular survival signaling in injured neurons by indirect cell-cell contact in an injury-dependent manner. In MK-801 exposure, NSCs increased phosphorylated Akt (p-Akt) and ERK (p-ERK), both of which were reduced by this stress. While, in serum/nutrient deprivation, NSCs increased p-Akt, but decreased p-ERK which was increased by this damage. Our results demonstrate that exogenous NSCs have anti-apoptotic activities and can rescue cortical neurons by directing cellular survival signaling of neurons into the proper direction, without cell contact.

    DOI: 10.1016/j.schres.2010.05.008

    PubMed

    researchmap

  • [Possible approach of regenerative medicine to treat alcohol-induced brain damage].

    Eri Hashimoto, Toshihiro Yoshinaga, Takao Ishii, Satoshi Saito, Wataru Ugai, Toshikazu Saito

    Nihon Arukoru Yakubutsu Igakkai zasshi = Japanese journal of alcohol studies & drug dependence   44 ( 6 )   674 - 9   2009.12

     More details

    Language:Japanese   Publishing type:Research paper (scientific journal)  

    PubMed

    researchmap

  • The common aspects of pathophysiolgy of alcoholism and depression.

    Wataru Ukai, Takao Ishii, Eri Hashimoto, Masaru Tateno, Toshihiro Yoshinaga, Takafumi Ono, Kimihiko Watanabe, Ippei Watanabe, Tomohiro Shirasaka, Toshikazu Saito

    Nihon Arukoru Yakubutsu Igakkai zasshi = Japanese journal of alcohol studies & drug dependence   44 ( 6 )   704 - 11   2009.12

     More details

    Language:English   Publishing type:Research paper (scientific journal)  

    Recent biological studies suggest the existence of the common pathophysiological aspects in alcoholism and depression. Postmortem studies have revealed the impairment of cAMP signaling in the patients with alcoholism. The similar alteration of cAMP signaling was also reported in postmortem brains of depressed patients. In this study, we supported the notion that neurogenesis would be essential in pathophysiology of both alcoholism and depression. Alcohol affected the function of neural stem cells (NSCs) and decreased neurogenesis at doses which did not affects cell survival, and treatment of antidepressant or moodstabilizer rescued the alcohol-induced suppression of neurogenesis. As the key mechanism of NSC differentiation change by ethanol and psychotropics, we focused on the transcriptional repressor, NRSF/REST activity change. Our in vitro studies demonstrated the NRSF/REST activation by ethanol and suppressive effect of antidepressants and lithium against its activation by ethanol. We further described the ERK reduction and ER stress in the cellular mechanism of NRSF/REST activation. All these findings suggested that cAMP-CREB cascade reduction and NRSF/REST activation may be common underlying mechanisms in the pathophysiology of alcoholism and depression.

    PubMed

    researchmap

  • [The analysis of impairment and repair of neural network by ethanol: in vitro and in vivo studies using neurons and neural stem cells].

    Wataru Ukai, Takao Ishii, Toshihiro Yoshinaga, Masaru Tateno, Eri Hashimoto, Takafumi Ono, Kimihiko Watanabe, Ippei Watanabe, Tomohiro Shirasaka, Toshikazu Saito

    Nihon Arukoru Yakubutsu Igakkai zasshi = Japanese journal of alcohol studies & drug dependence   43 ( 6 )   763 - 9   2008.12

     More details

    Language:Japanese   Publishing type:Research paper (scientific journal)  

    Recent clinical neuroimaging studies have suggested the morphological brain changes occur and progress in the course of alcoholism and depression. The abnormality of neurogenesis has emerged as a potential epidemiological mechanism of these diseases. Previously, we have indicated the low dose of ethanol that could not influence on the survival of neurons and neural stem cell (NSC) suppress differentiation to neurons but glias through activation of neuron-restrictive silencing factor/repressor element-1 silencing transcription factor (NRSF/REST). We revealed the endoplasmic reticulum function and trophic factor signaling change implicated in this mechanism of ethanol action on NSC differentiation change. The analysis of potentials of psychotropic drugs on the ethanol-induced NSC function change may reveal the possible biological way of neural network impairment and its repair. Furthermore, the approach of using stem cells such as intravenous NSC transplantation can be a useful method to clarify the neural network reconstruction damaged by ethanol. The importance of interactive analysis of in vitro to in vivo should be documented for the pathophysiological understanding and new therapy development against alcohol-induced brain damage.

    PubMed

    researchmap

  • Protective effects of psychotropic drugs on endoplasmic reticulum (ER) stress in psychiatric disorders Reviewed

    Toshikazu Saito, Wataru Ukai, Toshihiro Yoshinaga, Takao Ishii, Takafumi Ono, Kimihiko Watanabe, Eri Hashimoto

    JOURNAL OF NEURAL TRANSMISSION   115 ( 10 )   1474 - 1474   2008.10

     More details

    Language:English  

    Web of Science

    researchmap

  • [Epigenetic regulation in alcohol-related brain damage].

    Takao Ishii, Eri Hashimoto, Wataru Ukai, Masaru Tateno, Toshihiro Yoshinaga, Takahumi Ono, Kimihiko Watanabe, Satoshi Saito, Toshikazu Saito

    Nihon Arukoru Yakubutsu Igakkai zasshi = Japanese journal of alcohol studies & drug dependence   43 ( 5 )   705 - 13   2008.10

     More details

    Language:Japanese   Publishing type:Research paper (scientific journal)  

    Ethanol is a deleterious agent that causes various kinds of neuronal damage to both the developing and adult brain. Recent research on alcoholism implicates impaired function of neural stem cell (NSC) in the pathogenesis of ethanol-induced brain dysfunction. We previously reported that the differentiation of NSCs into neurons was significantly influenced by ethanol. We also found that neuron-restrictive silencer factor/repressor element 1-silencing transcription factor (NRSF/ REST) binding activity potentiated by ethanol underlies the mechanism of ethanol inhibition of neuronal differentiation. Epigenetics refers to post-translational modifications of DNA and nuclear proteins that produce lasting alterations in patterns of gene expression. Epigenetic mechanism plays a critical role of neuronal plasticity and there is clear evidence that dysfunction of epigenetic mechanism also contributes to neurological and psychiatric illness. We will review epigenetic regulation in pathogenesis of psychiatric illness including alcoholism. We also demonstrated that trichostatin A, histone deacetylase inhibitor, reduced the ethanol-induced suppression of neuronal differentiation of NSCs. We suggest that ethanol alters the function of neural differentiation through the mechanism of potentiation of NRSF/REST binding and histone modifications.

    PubMed

    researchmap

  • Lithium-induced suppression of transcription repressor NRSF/REST: effects on the dysfunction of neuronal differentiation by ethanol. International journal

    Takao Ishii, Eri Hashimoto, Wataru Ukai, Masaru Tateno, Toshihiro Yoshinaga, Satoshi Saito, Hitoshi Sohma, Toshikazu Saito

    European journal of pharmacology   593 ( 1-3 )   36 - 43   2008.9

     More details

    Language:English   Publishing type:Research paper (scientific journal)  

    Lithium, a mood-stabilizing drug, is widely used to treat bipolar affective disorder. Recent studies have demonstrated that lithium has neuroprotective and neurotrophic properties, which may relate to its clinical effectiveness. Ethanol is a deleterious agent that causes various kinds of neuronal damage to both the developing and adult brain. In this study, we investigated the potential of lithium to produce recovery of ethanol-induced suppressed neuronal differentiation at ethanol concentrations lower than those that affect the viability of neural stem cells (NSCs). We evaluated the effect of lithium on neuronal differentiation of NSCs obtained from rat embryos. To elucidate the molecular mechanisms underlying the altered neuronal differentiation induced by lithium and ethanol, we focused on neuron-restrictive silencer factor (NRSF), which represses transcription of neuronal genes in the terminal stage of NSC differentiation. Lithium increased neuronal differentiation and decreased ethanol-induced suppression of neuronal differentiation of NSCs. Furthermore, lithium reduced the DNA binding activity and protein level of NRSF enhanced by ethanol. Based on our findings, we speculate that lithium may be efficacious in the treatment of ethanol-induced neurological deficits.

    DOI: 10.1016/j.ejphar.2008.07.021

    PubMed

    researchmap

  • [Neural network abnormalities caused by alcohol: approach for repair using neural stem cells].

    Wataru Ukai, Eri Hashimoto, Toshihiro Yoshinaga, Takao Ishii, Masaru Tateno, Takafumi Ono, Kimihiko Watanabe, Satoshi Saito, Toshikazu Saito

    Nihon shinkei seishin yakurigaku zasshi = Japanese journal of psychopharmacology   28 ( 2 )   69 - 73   2008.4

     More details

    Language:Japanese   Publishing type:Research paper (scientific journal)  

    Recent clinical neuroimaging studies have revealed the possible relation between morphological brain changes, and memory, cognitive impairment in the course of alcoholism and depression. In the previous studies, we have been analyzing the mechanism of neural network disruption by ethanol using postmortem human brain and cultured cells, and identified the sensitive effect of ethanol on the neural stem cell (NSC) differentiation rather than the influence on neuronal cell survival. Furthermore, to develop a novel method for reconstruction of the neural network damaged by ethanol, we tried to analyze the usefulness of intravenous NSC transplantation in fetal alcohol syndrome spectrum disorder (FASD) model rats. In the in vitro studies, we have found the suppressive effect of ethanol on NSC differentiation to neurons, through alteration of transcription factor, CREB and NRSF/REST activities, by the cellular signaling cascade changes including trophic factors and endoplasmic reticulum (ER) function. In the in vivo studies, we have shown the effective migration of labeled NSCs into the brain of FASD model rats, and revealed the therapeutic potential of this transplantation for the treatment of anxiety/cognitive dysfunction and behavioral abnormalities in alcohol-induced brain neural network damage. We are going to the next step for analysis of transplanted NSC dynamics in the brain, which must play a pivotal role in the effective induction of behavioral recoveries.

    PubMed

    researchmap

  • The neural network reconstruction as a new therapy for treatment-resistant neuropsychiatric disorders

    鵜飼 渉, 橋本 恵理, 石井 貴男, 吉永 敏弘, 館農 勝, 齋藤 諭, 齋藤 利和

    札幌医学雑誌   76 ( 1 )   7 - 12   2007.6

     More details

    Language:Japanese   Publisher:札幌医科大学医学部  

    DOI: 10.15114/smj.76.7

    Ichushi

    researchmap

  • 【生体防御機構と精神疾患】向精神薬による神経新生増強とサイトカインシグナル伝達

    橋本 恵理, 鵜飼 渉, 今井 智之, 石井 貴男, 黒澤 茂樹, 吉永 敏弘, 齋藤 諭, 齋藤 利和

    脳と精神の医学   18 ( 2 )   103 - 110   2007.6

     More details

    Language:Japanese   Publisher:日本生物学的精神医学会  

    Ichushi

    J-GLOBAL

    researchmap

  • 抗うつ薬の作用機序に関する新たな視点での考察

    今井 智之, 鵜飼 渉, 石井 貴男, 黒澤 茂樹, 吉永 敏弘, 小野 貴文, 館農 勝, 齋藤 諭, 橋本 恵理, 池田 官司, 齋藤 利和

    分子精神医学   7 ( 2 )   161 - 163   2007.4

     More details

    Language:Japanese   Publisher:(株)先端医学社  

    Ichushi

    J-GLOBAL

    researchmap

  • The analysis of repair and regeneration of neural network by antidepressants: In vitro and in vivo studies using neural stem cells

    鵜飼渉, 今井智之, 石井貴男, 黒澤茂樹, 吉永敏弘, 小野貴文, 館農勝, 畠山佳久, 齋藤諭, 橋本恵理, 齋藤利和

    精神薬療研究年報   ( 39 )   209 - 218   2007.3

     More details

  • アルコール曝露モデルを用いた精神疾患への神経幹細胞移植(Neural stem cell transplantation for psychiatric disease using alcohol exposure model)

    Yoshinaga Toshihiro, Ukai Wataru, Ishii Takao, Imai Tomoyuki, Kurosawa Shigeki, Ono Takafumi, Saito Satoshi, Hashimoto Eri, Ikeda Hiroshi, Saito Toshikazu

    日本神経精神薬理学雑誌   26 ( 5-6 )   258 - 258   2006.11

     More details

    Language:English   Publisher:(一社)日本神経精神薬理学会  

    Ichushi

    researchmap

  • The molecular mechanism of ethanol inhibition of neurogenesis Reviewed

    Eri Hashimoto, Wataru Ukai, Masaru Tateno, Toshihiro Yoshinaga, Takao Ishii, Satoshi Saito, Toshikazu Saito

    ALCOHOLISM-CLINICAL AND EXPERIMENTAL RESEARCH   30 ( 9 )   112A - 112A   2006.9

     More details

    Language:English  

    Web of Science

    researchmap

  • Molecular mechanism of neural network impairment: The possible common pathophysiology of alcoholism and depression Reviewed

    Wataru Ukai, Toshikazu Saito, Takao Ishii, Tomoyuki Imai, Toshihiro Yoshinaga, Masaru Tateno, Eri Hashimoto, Hitoshi Sohma

    ALCOHOLISM-CLINICAL AND EXPERIMENTAL RESEARCH   30 ( 9 )   97A - 97A   2006.9

     More details

    Language:English  

    Web of Science

    researchmap

  • Ethanol effects on neuronal stem cell differentiation: A proteomic analysis Reviewed

    Gabriel C. James, Wataru Ukai, Takao Ishii, Eri Hashimoto, Toshikazu Saito, Izuru Matsumoto

    ALCOHOLISM-CLINICAL AND EXPERIMENTAL RESEARCH   30 ( 9 )   146A - 146A   2006.9

     More details

    Language:English  

    Web of Science

    researchmap

  • The molecular mechanism of damaged neural network formation by ethanol Reviewed

    Wataru Ukai, Takao Ishii, Tomoyuki Imai, Shigeki Kurosawa, Masaru Tateno, Satoshi Saito, Eri Hashimoto, Toshikazu Saito

    ALCOHOLISM-CLINICAL AND EXPERIMENTAL RESEARCH   30 ( 9 )   86A - 86A   2006.9

     More details

    Language:English  

    Web of Science

    researchmap

  • アルコールによる脳神経回路網修復・維持機構の変化

    石井 貴男, 鵜飼 渉, 今井 智之, 黒澤 茂樹, 吉永 敏弘, 館農 勝, 小野 貴文, 齋藤 諭, 橋本 恵理, 池田 官司, 齋藤 利和, 相馬 仁

    アルコールと医学生物学   26   81 - 87   2006.9

     More details

    Language:Japanese   Publisher:(株)響文社  

    Ichushi

    J-GLOBAL

    researchmap

  • Impairment of neural differentiation: The common mechanism of alcoholics and depression Reviewed

    Takao Ishii, Wataru Ukai, Tomoyuki Imai, Shigeki Kurosawa, Toshihiro Yoshinaga, Tateno Masaru, Eri Hashimoto, Toshikazu Saito

    ALCOHOLISM-CLINICAL AND EXPERIMENTAL RESEARCH   30 ( 9 )   146A - 146A   2006.9

     More details

    Language:English  

    Web of Science

    researchmap

  • 神経表現型質による抗うつ薬誘発神経発生の解析(Analysis of antidepressants-induced neurogenesis by characterizing the neuronal phenotypes)

    Imai Tomoyuki, Ukai Wataru, Ishii Takao, Kurosawa Shigeki, Yoshinaga Toshihiro, Ono Takafumi, Saito Satoshi, Hashimoto Eri, Ikeda Hiroshi, Saito Toshikazu

    神経化学   45 ( 2-3 )   540 - 540   2006.8

     More details

    Language:English   Publisher:日本神経化学会  

    Ichushi

    researchmap

  • 抗精神病薬による神経保護作用の機序

    黒澤 茂樹, 今井 智之, 鵜飼 渉, 石井 貴男, 小野 貴文, 吉永 敏弘, 斉藤 諭, 橋本 恵理, 池田 官司, 齋藤 利和

    神経化学   45 ( 2-3 )   359 - 359   2006.8

     More details

    Language:Japanese   Publisher:日本神経化学会  

    Ichushi

    researchmap

  • アルコール曝露モデルを用いた精神病に対する神経幹細胞移植(Neural stem cell transplantation for psychiatric disease using alcohol exposure model)

    Yoshinaga Toshihiro, Ukai Wataru, Ishii Takao, Imai Tomoyuki, Kurosawa Shigeki, Ono Takafumi, Saito Satoshi, Hashimoto Eri, Ikeda Hiroshi, Saito Toshikazu

    神経化学   45 ( 2-3 )   324 - 324   2006.8

     More details

    Language:English   Publisher:日本神経化学会  

    Ichushi

    researchmap

  • 生体防御機構と精神疾患 向精神薬による神経新生増強とサイトカインシグナル伝達

    橋本 恵理, 鵜飼 渉, 今井 智之, 石井 貴男, 黒澤 茂樹, 吉永 敏弘, 齋藤 諭, 池田 官司, 齋藤 利和

    神経化学   45 ( 2-3 )   261 - 261   2006.8

     More details

    Language:Japanese   Publisher:日本神経化学会  

    Ichushi

    researchmap

  • The approach of reconstruction of damaged neural network by ethanol Reviewed

    Toshikazu Saito, Eri Hashimoto, Wataru Ukai, Takao Ishii

    ALCOHOLISM-CLINICAL AND EXPERIMENTAL RESEARCH   30 ( 6 )   70A - 70A   2006.6

     More details

    Language:English  

    Web of Science

    researchmap

  • Impairment of neural stem cell differentiation : The common pathophysiology of alcoholism and depression

    ISHII Takao, UKAI Wataru, YOSHINAGA Toshihiro, TATENO Masaru, HASHIMOTO Eri, SAITO Toshikazu

    41 ( 3 )   182 - 183   2006.6

     More details

    Language:Japanese  

    Ichushi

    researchmap

  • 若手精神科医の立場から精神医療を考える 精神医療の現状と地域の抱える課題 東北・北海道の地域精神医療の課題と試み

    今村 弥生, 石井 貴男, 今井 智之, 菊地 紗耶, 橋本 直樹

    精神神経学雑誌   ( 2006特別 )   S318 - S318   2006.5

     More details

    Language:Japanese   Publisher:(公社)日本精神神経学会  

    Ichushi

    researchmap

  • The analysis of reconstruction mechanism of neural network by antidepressants: Implication of endoplasmic reticulum function change

    鵜飼渉, 今井智之, 石井貴男, 黒沢茂樹, 吉永敏弘, 館農勝, 斎藤諭, 橋本恵理, 池田官司, 斎藤利和

    精神薬療研究年報   ( 38 )   130 - 138   2006.3

     More details

  • [Possibility for regional psychiatric care in Tohoku and Hokkaido areas].

    Yayoi Imamura, Takao Ishii, Tomoyuki Imai, Saya Kikuchi, Naoki Hashimoto

    Seishin shinkeigaku zasshi = Psychiatria et neurologia Japonica   108 ( 9 )   957 - 60   2006

     More details

    Language:Japanese   Publishing type:Research paper (scientific journal)  

    PubMed

    researchmap

  • 抗鬱剤と気分安定剤による神経回路網の再構築機構(The reconstruction mechanisms of neural network by antidepressants and mood stabilizers)

    今井 智之, 鵜飼 渉, 石井 貴男, 黒澤 茂樹, 吉永 敏弘, 齋藤 諭, 橋本 恵理, 池田 官司, 齋藤 利和

    神経化学   44 ( 2-3 )   200 - 200   2005.8

     More details

    Language:English   Publisher:日本神経化学会  

    Ichushi

    researchmap

  • 向精神薬の作用機序に関する新しい見解 神経の発生と生存に対する抗精神薬の効果(The Effects of Antipsychotics on Neurogenesis and survival)

    鵜飼 渉, 黒澤 茂樹, 石井 貴男, 今井 智之, 吉永 敏弘, 齋藤 諭, 橋本 恵理, 池田 官司, 齋藤 利和

    神経化学   44 ( 2-3 )   162 - 162   2005.8

     More details

    Language:English   Publisher:日本神経化学会  

    Ichushi

    researchmap

  • Implication of neurogenesis and neural network disturbance in the pathophysiology of depression

    鵜飼渉, 館農勝, 今井智之, 石井貴男, 黒沢茂樹, 橋本恵理, 池田官司, 斎藤利和

    精神薬療研究年報   ( 37 )   198 - 204   2005.3

     More details

▼display all

MISC

  • 最先端医療の今 シンクロナイザーニューロン活性化による統合失調症の社会性/職業機能回復の試み

    鵜飼 渉, 出利葉 健太, 西村 恵美, 橋本 恵理, 森元 隆文, 石井 貴男, Riva Marco A., 河西 千秋

    Medical Science Digest   50 ( 14 )   823 - 826   2024.12

     More details

    Language:Japanese   Publisher:(株)ニュー・サイエンス社  

    Ichushi

    researchmap

  • 精神科リエゾンにおける作業療法士の実践 スコーピングレビュー

    石井 貴男, 森元 隆文, 島田 清貴

    総合病院精神医学   36 ( Suppl. )   S - 257   2024.11

     More details

    Language:Japanese   Publisher:(一社)日本総合病院精神医学会  

    Ichushi

    researchmap

  • 難治性精神疾患の脳病態と新規治療法の探索 薬物と幹細胞による社会性/共感性の行動・脳神経回路変動解析

    鵜飼 渉, 出利葉 健太, 西村 恵美, 橋本 恵理, 廣瀬 奨真, 橋口 華子, 望月 真里菜, 古瀬 研吾, 石井 貴男, 柏木 智則, 館農 勝, リーバ・マルコ, 河西 千秋

    精神神経学雑誌   ( 2024特別号 )   S540 - S540   2024.6

     More details

    Language:Japanese   Publisher:(公社)日本精神神経学会  

    Ichushi

    researchmap

  • 自殺未遂者へのアサーティヴ・ケースマネジメントの実装 多施設共同コホート研究

    石井 貴男, 米本 直裕, 大高 靖史, 岡村 和哉, 辻井 農亜, 大塚 耕太郎, 吉村 玲児, 木下 利彦, 藤澤 大介, 太刀川 弘和, 山田 光彦, 津山 雄亮, 橋本 聡, 河西 千秋

    総合病院精神医学   35 ( Suppl. )   S - 166   2023.11

     More details

    Language:Japanese   Publisher:(一社)日本総合病院精神医学会  

    Ichushi

    researchmap

  • 自殺未遂者へのアサーティヴ・ケースマネジメントの実装 多施設共同コホート研究

    石井 貴男, 米本 直裕, 大高 靖史, 岡村 和哉, 辻井 農亜, 大塚 耕太郎, 吉村 玲児, 木下 利彦, 藤澤 大介, 太刀川 弘和, 山田 光彦, 津山 雄亮, 橋本 聡, 河西 千秋

    総合病院精神医学   35 ( Suppl. )   S - 166   2023.11

     More details

    Language:Japanese   Publisher:(一社)日本総合病院精神医学会  

    Ichushi

    researchmap

  • 発達期環境ストレス誘発統合失調症の病態生理の探索 抗精神病薬によるパルブアルブミン陽性細胞変異に焦点を当てた発症予防法開発を目指す試み

    出利葉 健太, 鵜飼 渉, 西村 恵美, 橋本 恵理, 橋口 華子, 廣瀬 奨真, 望月 真里菜, 桃木 幸彦, 古瀬 研吾, 石井 貴男, Riva Marco A., 河西 千秋

    日本神経精神薬理学会年会プログラム・抄録集   53回   153 - 153   2023.9

     More details

    Language:Japanese   Publisher:(一社)日本神経精神薬理学会  

    Ichushi

    researchmap

  • 難治性精神疾患と周産期メンタルヘルス異常の病態・治療法探索 漢方薬と幹細胞を用いた社会性/共感性の行動・脳神経回路変動の解析

    鵜飼 渉, 出利葉 健太, 西村 恵美, 橋本 恵理, 山田 美佐, 橋口 華子, 廣瀬 奨真, 望月 真里菜, 桃木 幸彦, 古瀬 研吾, 石井 貴男, リーバ・マルコ, 河西 千秋

    日本神経精神薬理学会年会プログラム・抄録集   53回   151 - 151   2023.9

     More details

    Language:Japanese   Publisher:(一社)日本神経精神薬理学会  

    Ichushi

    researchmap

  • 性欲の異常亢進と誤診されていたrestless genital syndromeの1例

    廣瀬 奨真, 大江 開, 野呂 孝徳, 石井 貴男, 河西 千秋

    精神神経学雑誌   124 ( 12 )   894 - 894   2022.12

     More details

    Language:Japanese   Publisher:(公社)日本精神神経学会  

    Ichushi

    researchmap

  • 皮膚寄生虫妄想を呈したレビー小体型認知症の1例

    姜 撤求, 大江 開, 野呂 孝徳, 石井 貴男, 河西 千秋

    精神神経学雑誌   124 ( 12 )   894 - 894   2022.12

     More details

    Language:Japanese   Publisher:(公社)日本精神神経学会  

    Ichushi

    researchmap

  • 札幌医科大学附属病院高度救命救急センターに搬送された自殺企図事例の実態調査

    石橋 竜太朗, 佐野 智章, 大江 開, 津山 雄亮, 岩木 敦子, 昌川 安希子, 柏木 智則, 古俣 皓涼, 石井 貴男, 河西 千秋

    総合病院精神医学   34 ( Suppl. )   S - 163   2022.10

     More details

    Language:Japanese   Publisher:(一社)日本総合病院精神医学会  

    Ichushi

    researchmap

  • がん患者の自殺予防を目的としたケース・マネジメント介入 フィジビリティ研究

    石井 貴男, 岩木 敦子, 津山 雄亮, 菅原 夏海, 成田 賢治, 大江 開, 佐野 智章, 河西 千秋

    総合病院精神医学   34 ( Suppl. )   S - 186   2022.10

     More details

    Language:Japanese   Publisher:(一社)日本総合病院精神医学会  

    Ichushi

    researchmap

  • 札幌医科大学附属病院高度救命救急センターに搬送された自殺企図事例の実態

    古俣 皓涼, 石橋 竜太朗, 佐野 智章, 大江 開, 津山 雄亮, 岩木 敦子, 昌川 安希子, 柏木 智則, 石井 貴男, 河西 千秋

    日本精神科救急学会学術総会プログラム・抄録集   30回   161 - 161   2022.9

     More details

    Language:Japanese   Publisher:(一社)日本精神科救急学会  

    Ichushi

    researchmap

  • 自殺未遂者家族の支援の在り方に関する質的研究 1家族との1年半にわたる面接に基づく予備的研究

    煤賀 隆宏, 岩木 敦子, 石井 貴男, 河西 千秋

    自殺予防と危機介入   42 ( 2 )   32 - 40   2022.9

     More details

    Language:Japanese   Publisher:(一社)日本自殺予防学会  

    Ichushi

    researchmap

  • レビー小体型認知症に対する修正型電気けいれん療法の有効性と実施課題

    佐野 智章, 野呂 孝徳, 石橋 竜太朗, 石井 貴男, 河西 千秋

    精神神経学雑誌   124 ( 7 )   503 - 503   2022.7

     More details

    Language:Japanese   Publisher:(公社)日本精神神経学会  

    Ichushi

    researchmap

  • 化膿性膝関節炎の治療中に生じた抗菌薬関連脳症の1例

    古俣 皓涼, 石橋 竜太朗, 柏木 智則, 石井 貴男, 河西 千秋

    精神神経学雑誌   124 ( 7 )   501 - 501   2022.7

     More details

    Language:Japanese   Publisher:(公社)日本精神神経学会  

    Ichushi

    researchmap

  • 「自殺未遂者の自殺再企図防止のための救急患者精神科継続支援」を受けた自殺企図患者の心理社会的特徴

    菅原 夏海, 岩木 敦子, 昌川 安希子, 津山 雄亮, 柏木 智則, 石橋 竜太朗, 石井 貴男, 河西 千秋

    精神神経学雑誌   124 ( 7 )   504 - 504   2022.7

     More details

    Language:Japanese   Publisher:(公社)日本精神神経学会  

    Ichushi

    researchmap

  • メンタルヘルス支援と自殺予防のためのケース・マネジメント介入を実施した乳がん患者の1例

    岩木 敦子, 佐藤 明美, 石井 貴男, 出利葉 健太, 成田 賢治, 大江 開, 佐野 智章, 河西 千秋

    精神神経学雑誌   124 ( 7 )   504 - 504   2022.7

     More details

    Language:Japanese   Publisher:(公社)日本精神神経学会  

    Ichushi

    researchmap

  • 統合失調症モデルにおける社会認知機能障害とパルブアルブミン陽性ニューロン変化についての検討

    出利葉 健太, 鵜飼 渉, Riva Marco A., 西村 恵美, 橋本 恵理, 橋口 華子, 田山 真矢, 村山 友規, 古瀬 研吾, 石井 貴男, 河西 千秋

    精神神経学雑誌   124 ( 5 )   360 - 360   2022.5

     More details

    Language:Japanese   Publisher:(公社)日本精神神経学会  

    Ichushi

    researchmap

  • 【精神科診療のピットフォール】総論 自殺予防と自殺企図者への対応 Invited

    石橋 竜太朗, 石井 貴男, 河西 千秋

    精神医学   64 ( 5 )   543 - 550   2022.5

     More details

    Language:Japanese   Publisher:(株)医学書院  

    Ichushi

    researchmap

  • ケース・マネジメント介入を実施した自殺企図患者の精神医学的特徴と予後

    石橋 竜太朗, 津山 雄亮, 岩木 敦子, 昌川 安希子, 石井 貴男, 河西 千秋

    精神神経学雑誌   124 ( 5 )   360 - 360   2022.5

     More details

    Language:Japanese   Publisher:(公社)日本精神神経学会  

    Ichushi

    researchmap

  • 統合失調症の社会性行動回復 海馬-扁桃体系E/IバランスとBdnf long-3'UTR機構の関与

    出利葉 健太, 鵜飼 渉, Marchisella Francesca, 西村 恵美, 橋本 恵理, 橋口 華子, 古瀬 研吾, 田山 真矢, 廣瀬 奨真, 石井 貴男, Riva Marco, 河西 千秋

    精神神経学雑誌   124 ( 4付録 )   S - 546   2022.4

     More details

    Language:Japanese   Publisher:(公社)日本精神神経学会  

    Ichushi

    researchmap

  • 【高齢患者の精神科コンサルテーション・リエゾン(CLP)】高齢者のリエゾン 高齢者の自殺企図への対応 Invited

    野呂 孝徳, 石井 貴男, 河西 千秋

    老年精神医学雑誌   33 ( 1 )   53 - 58   2022.1

     More details

    Language:Japanese   Publisher:(株)ワールドプランニング  

    Ichushi

    researchmap

  • Assertive case management介入を実施した自殺企図患者の心理社会的特徴

    佐野 智章, 石橋 竜太朗, 岩木 敦子, 昌川 安希子, 柏木 智則, 石井 貴男, 津山 雄亮, 河西 千秋

    総合病院精神医学   33 ( Suppl. )   S - 206   2021.11

     More details

    Language:Japanese   Publisher:(一社)日本総合病院精神医学会  

    Ichushi

    researchmap

  • 北日本政令指定都市の大学附属病院における精神科リエゾン・コンサルテーションの推移

    柏木 智則, 昌川 安希子, 煤賀 隆宏, 澤田 賢人, 森元 隆文, 石井 貴男, 河西 千秋

    総合病院精神医学   33 ( Suppl. )   S - 197   2021.11

     More details

    Language:Japanese   Publisher:(一社)日本総合病院精神医学会  

    Ichushi

    researchmap

  • 総合病院と自殺 総合病院における自殺予防医療と地域貢献

    河西 千秋, 柏木 智則, 石井 貴男

    総合病院精神医学   33 ( Suppl. )   S - 71   2021.11

     More details

    Language:Japanese   Publisher:(一社)日本総合病院精神医学会  

    Ichushi

    researchmap

  • 【今日の精神科治療ハンドブック】(第15章)コンサルテーション・リエゾン(二次性の精神および行動の症候群を含む) 自殺関連行動への対応 Invited

    石井 貴男, 石橋 竜太朗, 河西 千秋

    精神科治療学   36 ( 増刊 )   324 - 327   2021.10

     More details

    Authorship:Lead author   Language:Japanese   Publisher:(株)星和書店  

    Ichushi

    researchmap

  • 救命救急センターに搬送される自殺企図者に対する精神科医の役割 自殺企図で救命救急センターに搬送される重症患者の臨床的特徴と対応

    石井 貴男, 河西 千秋

    精神神経学雑誌   ( 2021特別号 )   S411 - S411   2021.9

     More details

    Language:Japanese   Publisher:(公社)日本精神神経学会  

    Ichushi

    researchmap

  • 成人期ADHDの心理検査における特徴

    伊東 美波, 石井 貴男, 白石 将毅, 煤賀 隆宏, 谷内 早苗, 津山 雄亮, 河西 千秋

    総合病院精神医学   31 ( Suppl. )   S - 246   2019.11

     More details

    Language:Japanese   Publisher:(一社)日本総合病院精神医学会  

    Ichushi

    researchmap

  • 厚生労働省自殺未遂者再企図防止事業 臨床現場におけるケース・マネージメント介入の実態

    白石 将毅, 石井 貴男, 津山 雄亮, 岩木 敦子, 野呂 孝徳, 成田 賢治, 煤賀 隆宏, 田山 真矢, 木川 昌康, 河西 千秋

    精神神経学雑誌   ( 2019特別号 )   S642 - S642   2019.6

     More details

    Language:Japanese   Publisher:(公社)日本精神神経学会  

    Ichushi

    researchmap

  • 深い学びの要 ディープコミュニケーションとは何か どことどこで会話をしているのか

    鵜飼 渉, 辻野 華子, 杉村 政樹, 木川 昌康, 田山 真矢, 石井 貴男, 古瀬 研吾, 廣瀬 奨真, 橋本 恵理, 澤田 いずみ, 山本 武志, 白鳥 正典, 河西 千秋, 相馬 仁

    医療人育成センター紀要   9   35 - 43   2018.3

     More details

    Language:Japanese   Publisher:札幌医科大学医療人育成センター  

    Ichushi

    researchmap

  • JSNP Excellent Presentation Award for CINP2016: Epigenetic Status of LINE-1 Promoters in Neurons and Non-neurons

    Risa Watanabe, Masaki Nishioka, Miki Bundo, Yutaka Sawai, Junko Ueda, Yui Murata, Takao Ishii, Wataru Ukai, Eri Hashimoto, Kiyoto Kasai, Siro Simizu, Tadafiimi Kato, Kazuya Iwamoto

    Japanese Journal of Neuropsychopharmacology   37 ( 3 )   83 - 84   2017.6

     More details

    Language:English   Publishing type:Research paper, summary (international conference)  

    researchmap

  • 統合失調症との鑑別を要した下垂体前葉機能低下症による器質性精神病

    今井 智之, 白坂 知彦, 石井 貴男

    精神神経学雑誌   118 ( 9 )   716 - 716   2016.9

     More details

    Language:Japanese   Publisher:(公社)日本精神神経学会  

    Ichushi

    J-GLOBAL

    researchmap

  • ヒト死後脳の神経細胞と非神経細胞におけるLINE‐1プロモーターのエピジェネティック修飾状態の検討

    渡邊理紗, 渡邊理紗, 西岡将基, 西岡将基, 文東美紀, 澤井大和, 澤井大和, 上田順子, 村田唯, 村田唯, 石井貴男, 鵜飼渉, 橋本恵理, 笠井清登, 清水史郎, 加藤忠史, 岩本和也

    日本神経精神薬理学会プログラム・抄録集   46th   243 - 243   2016

     More details

    Language:Japanese   Publishing type:Research paper, summary (national, other academic conference)  

    Ichushi

    J-GLOBAL

    researchmap

  • 統合失調症と若年性アルツハイマー型認知症の合併が疑われた一例

    IDERIHA KENTA, MATSUYAMA KIYOJI, KOBAYASHI SEIJU, ISHII TAKAO, HASHIMOTO ERI, KAWANISHI CHIAKI

    日本精神神経学会総会プログラム・抄録集   111th ( 2015特別 )   S563 - S563   2015.6

     More details

    Language:Japanese   Publisher:(公社)日本精神神経学会  

    Ichushi

    J-GLOBAL

    researchmap

  • 各領域から考える自殺予防と精神保健 大学、病院、企業における現状と課題 大学教職員の自殺予防とメンタルヘルス

    河西 千秋, 平安 良雄, 井出 恵子, 石井 貴男, 小林 清樹

    精神神経学雑誌   118 ( 2015特別 )   S717 - S717   2015.6

     More details

    Language:Japanese   Publisher:(公社)日本精神神経学会  

    Other Link:: http://search.jamas.or.jp/link/ui/2016150873

    Ichushi

    researchmap

  • 胎児期アルコール曝露と成長後のストレスを組み合わせた難治性うつ病モデルにおける神経幹細胞移植療法の有効性

    鵜飼 渉, 木川 昌康, 石井 貴男, 古瀬 研吾, 辻野 華子, 岩本 倫, 田山 真矢, 白石 将毅, 橋本 恵理, 河西 千秋, 齋藤 利和

    アルコールと医学生物学   33   39 - 44   2015.3

     More details

    Language:Japanese   Publisher:(株)響文社  

    Ichushi

    researchmap

  • 統合失調症にアルツハイマー型認知症を合併した1例

    DERIBA KENTA, MATSUYAMA KIYOJI, KOBAYASHI SEIJU, FURUSE KENGO, ISHII TAKAO, HASHIMOTO ERI

    精神神経学雑誌   116 ( 12 )   1039 - 1040   2014.12

     More details

    Language:Japanese   Publisher:(公社)日本精神神経学会  

    Ichushi

    J-GLOBAL

    researchmap

  • レヴィー小体型認知症に対するECTの有効性

    早坂 郁, 松山 清治, 坂田 太, 白石 将毅, 荻原 英之, 小林 清樹, 石井 貴男, 橋本 恵理

    精神神経学雑誌   116 ( 12 )   1039 - 1039   2014.12

     More details

    Language:Japanese   Publisher:(公社)日本精神神経学会  

    Ichushi

    researchmap

  • COMBINED APPLICATION OF DRUG AND STEM CELLS FOR TREATING ALCOHOL-INDUCED BRAIN DAMAGE AND DEPRESSION

    W. Ukai, Y. Kigawa, T. Ishii, K. Furuse, H. Tsujino, E. Hashimoto, T. Saito

    ALCOHOL AND ALCOHOLISM   49   2014.9

     More details

    Language:English   Publishing type:Research paper, summary (international conference)  

    Web of Science

    researchmap

  • Stem cell therapy as a candidate treatment approach for neural plasticity change in alcohol-induced brain damage and depression

    W. Ukai, Y. Kigawa, E. Hashimoto, T. Ishii, K. Fuluse, H. Tsujino, T. Saito

    INTERNATIONAL JOURNAL OF NEUROPSYCHOPHARMACOLOGY   17   172 - 173   2014.6

     More details

    Language:English   Publishing type:Research paper, summary (international conference)  

    Web of Science

    researchmap

  • 抗うつ効果とBipolarityの診断の糸口を求めて 血小板BDNF遊離機能の個体差のメカニズム解析から

    橋本 恵理, 鵜飼 渉, 石井 貴男, 木川 昌康, 古瀬 健吾, 辻野 華子, 齋藤 利和

    精神薬療研究年報   ( 46 )   50 - 51   2014.3

     More details

    Language:Japanese   Publisher:(公財)先進医薬研究振興財団  

    Ichushi

    researchmap

  • 末梢血血小板からの神経栄養因子遊離に及ぼす抗うつ薬の効果とアルコールの影響について

    石井 貴男, 鵜飼 渉, 橋本 恵理, 渡邊 公彦, 金田 博雄, 木川 昌康, 白坂 知彦, 五十嵐 健史, 吉永 敏弘, 館農 勝, 齋藤 利和

    アルコールと医学生物学   32   144 - 144   2014.1

     More details

    Language:Japanese   Publisher:(株)響文社  

    Ichushi

    researchmap

  • 依存研究を基盤にした精神疾患の病因解明の試み 精神疾患に対する再生医療的アプローチの可能性

    鵜飼 渉, 橋本 恵理, 石井 貴男, 木川 昌康, 古瀬 健吾, 辻野 華子, 白坂 知彦, 吉永 敏弘, 小林 清樹, 齋藤 利和

    日本臨床精神神経薬理学会・日本神経精神薬理学会合同年会プログラム・抄録集   23回・43回   130 - 130   2013.10

     More details

    Language:Japanese   Publisher:日本臨床精神神経薬理学会・日本神経精神薬理学会  

    Ichushi

    researchmap

  • UNDERSTANDING OF MECHANISMS UNDERLYING BRAIN ABNORMALITY IN FASD AND ITS TRANSLATIONAL APPROACH

    W. Ukai, E. Hashimoto, T. Shirasaka, T. Ishii, T. Yoshinaga, Y. Kigawa, M. Tateno, S. Kobayashi, T. Saito

    ALCOHOL AND ALCOHOLISM   48   19 - 19   2013.9

     More details

    Language:English   Publishing type:Research paper, summary (international conference)  

    Web of Science

    researchmap

  • BASIC ASPECTS OF ALCOHOL USE DISORDER COMORBID WITH DEPRESSIVE DISORDER

    E. Hashimoto, W. Ukai, T. Ishii, Y. Kigawa, T. Yoshinaga, K. Watanabe, T. Shirasaka, M. Tateno, S. Kobayashi, T. Saito

    ALCOHOL AND ALCOHOLISM   48   28 - 28   2013.9

     More details

    Language:English   Publishing type:Research paper, summary (international conference)  

    Web of Science

    researchmap

  • 精神疾患に対する神経幹細胞移植療法を用いた新しい治療法の可能性

    白坂 知彦, 鵜飼 渉, 木川 昌康, 石井 貴男, 吉永 敏弘, 金田 博雄, 橋本 恵理, 齋藤 利和

    精神神経学雑誌   ( 2013特別 )   S - 685   2013.5

     More details

    Language:Japanese   Publisher:(公社)日本精神神経学会  

    Ichushi

    researchmap

  • 経静脈的神経幹細胞移植によるFASDモデルラットの行動異常改善と脳神経回路シナプス形成の修復

    齋藤 利和, 鵜飼 渉, 白坂 知彦, 橋本 恵理, 吉永 敏弘, 金田 博雄, 五十嵐 健史, 渡邊 公彦, 館農 勝, 石井 貴男

    アルコールと医学生物学   31   40 - 40   2012.10

     More details

    Language:Japanese   Publisher:(株)響文社  

    Ichushi

    researchmap

  • INTRAVENOUS NEURAL STEM CELL TRANSPLANTATION - A STRATEGY FOR FACILITATION OF NEURAL NETWORK AND BEHAVIORAL RECOVERY

    T. Shirasaka, W. Ukai, E. Hashimoto, H. Kaneta, T. Igarashi, Y. Kigawa, K. Watanabe, T. Ishii, T. Yoshinaga, S. Kobayashi, M. Tateno, T. Saito

    ALCOHOLISM-CLINICAL AND EXPERIMENTAL RESEARCH   36   110A - 110A   2012.9

     More details

    Language:English   Publishing type:Research paper, summary (international conference)  

    Web of Science

    researchmap

  • BDNF AS A POTENTIALBIOMARKER FOR FETAL ALCOHOL EFFECTS- COMPARATIVE STUDY OF SERUM CONSENTRATIONS IN RAT MODEL

    T. Igarashi, K. Watanabe, W. Ukai, E. Hashimoto, T. Shirasaka, H. Kaneta, Y. Kigawa, T. Ishii, T. Yoshinaga, S. Kobayashi, M. Tateno, T. Saito

    ALCOHOLISM-CLINICAL AND EXPERIMENTAL RESEARCH   36   120A - 120A   2012.9

     More details

    Language:English   Publishing type:Research paper, summary (international conference)  

    Web of Science

    researchmap

  • ALCOHOL, EPIGENETICS AND BRAIN DAMAGE

    W. Ukai, T. Shirasaka, E. Hashimoto, H. Kaneta, T. Igarashi, M. Kigawa, K. Watanabe, T. Yoshinaga, M. Tateno, T. Ishii, T. Saito

    ALCOHOLISM-CLINICAL AND EXPERIMENTAL RESEARCH   36   57A - 57A   2012.9

     More details

    Language:English   Publishing type:Research paper, summary (international conference)  

    Web of Science

    researchmap

  • The effect of antipsychotics on GABAergic interneurogenesis in adult brain

    W. Ukai, H. Kaneta, E. Hashimoto, T. Igarashi, T. Shirasaka, Y. Kigawa, K. Watanabe, T. Yoshinaga, M. Tateno, T. Ishii, T. Saito

    INTERNATIONAL JOURNAL OF NEUROPSYCHOPHARMACOLOGY   15   138 - 138   2012.6

     More details

    Language:English   Publishing type:Research paper, summary (international conference)  

    Web of Science

    researchmap

  • 統合失調症の脳神経回路修復 薬物・細胞コンバインド療法の可能性の検討 Reviewed

    鵜飼 渉, 小野 貴文, 橋本 恵理, 金田 博雄, 白坂 知彦, 五十嵐 健史, 木川 昌康, 渡邊 公彦, 吉永 敏弘, 石井 貴男, 館農 勝, 小林 清樹, 齋藤 利和

    日本生物学的精神医学会誌   23 ( 2 )   109 - 114   2012

  • 統合失調症治療薬が神経幹細胞のインターニューロンへの分化に及ぼす影響について(The effect of antipsychotics on interneurogenesis of adult neural stem cells)

    金田 博雄, 鵜飼 渉, 橋本 恵理, 吉永 敏弘, 館農 勝, 渡邊 公彦, 白坂 知彦, 五十嵐 健史, 石井 貴男, 齋藤 利和

    神経化学   50 ( 2-3 )   177 - 177   2011.9

     More details

    Language:English   Publisher:日本神経化学会  

    Ichushi

    researchmap

  • PROMOTION OF INTERNEUROGENESIS BY NEURAL STEM CELL TRANSPLANTATION IN FASD MODEL

    W. Ukai, T. Shirasaka, E. Hashimoto, T. Yoshinaga, H. Kaneta, M. Kigawa, T. Igarashi, K. Watanabe, M. Tateno, T. Ishii, T. Saito

    ALCOHOL AND ALCOHOLISM   46   43 - 44   2011.9

     More details

    Language:English   Publishing type:Research paper, summary (international conference)  

    Web of Science

    researchmap

  • STEM CELL THERAPY: A NOVEL TREATMENT STRATEGY FOR FETAL ALCOHOL SPECTRUM DISORDER

    T. Saito, T. Shirasaka, E. Hashimoto, W. Ukai, T. Yoshinaga, T. Ishii, M. Tateno, K. Watanabe, I. Watanabe, M. Kigawa, H. Kaneta

    ALCOHOLISM-CLINICAL AND EXPERIMENTAL RESEARCH   35 ( 6 )   38A - 38A   2011.6

     More details

    Language:English   Publishing type:Research paper, summary (international conference)  

    Web of Science

    researchmap

  • Ethanol-Induced Growth Factor Dysfunctions in Neural Stem Cells: Implications to Stress

    W. Ukai, E. Hashimoto, T. Ishii, M. Tateno, K. Watanabe, I. Watanabe, T. Shirasaka, H. Kaneta, M. Kigawa, T. Igarashi, T. Yoshinaga, T. Saito

    ALCOHOL   45 ( 3 )   275 - 275   2011.5

     More details

    Language:English   Publishing type:Research paper, summary (international conference)  

    Web of Science

    researchmap

  • 【日本の生物学的ストレス研究の紹介】 ストレスによる脳神経回路網変異 障害と修復の分子メカニズム

    鵜飼 渉, 橋本 恵理, 吉永 敏弘, 白坂 知彦, 渡邊 公彦, 渡邉 一平, 金田 博雄, 館農 勝, 石井 貴男, 齋藤 利和

    ストレス科学   25 ( 3 )   167 - 177   2010.12

  • STEM CELL REGULATION AS A NEW TREATMENT STRATEGY FOR ALCOHOLISM AND OTHER PSYCHIATRIC DISORDERS

    T. Saito, E. Hashimoto, W. Ukai, T. Yoshinaga, T. Ishii, M. Tateno, T. Ono, T. Shirasaka, K. Watanabe, I. Watanabe

    ALCOHOLISM-CLINICAL AND EXPERIMENTAL RESEARCH   34 ( 8 )   72A - 72A   2010.8

     More details

    Language:English   Publishing type:Research paper, summary (international conference)  

    Web of Science

    researchmap

  • ALCOHOL INDUCED NEUROGENETIC DYSFUNCTION: ROLES OF TRANSCRIPTION FACTORS AND EPIGENETIC REGULATION

    W. Ukai, E. Hashimoto, T. Ishii, M. Tateno, T. Ono, K. Watanabe, I. Watanabe, T. Shirasaka, T. Yoshinaga, T. Saito

    ALCOHOLISM-CLINICAL AND EXPERIMENTAL RESEARCH   34 ( 8 )   49A - 49A   2010.8

     More details

    Language:English   Publishing type:Research paper, summary (international conference)  

    Web of Science

    researchmap

  • STEM CELL THERAPY - SOCIAL FUNCTION RECOVERY IN FASD MODEL

    T. Shirasaka, W. Ukai, E. Hashimoto, T. Ono, T. Yoshinaga, T. Ishii, M. Tateno, K. Watanabe, I. Watanabe, H. Kaneta, Y. Kigawa, T. Saito

    ALCOHOLISM-CLINICAL AND EXPERIMENTAL RESEARCH   34 ( 8 )   98A - 98A   2010.8

     More details

    Language:English   Publishing type:Research paper, summary (international conference)  

    Web of Science

    researchmap

  • STEM CELL THERAPY AS A NEW TREATMENT STRATEGY FOR ALCOHOL-INDUCED BRAIN DAMAGE

    T. Saito, E. Hashimoto, W. Ukai, T. Shirasaka, T. Ono, T. Yoshinaga, T. Ishii, M. Tateno, K. Watanabe, I. Watanabe, M. Kigawa, H. Kaneda

    ALCOHOLISM-CLINICAL AND EXPERIMENTAL RESEARCH   34 ( 6 )   215A - 215A   2010.6

     More details

    Language:English   Publishing type:Research paper, summary (international conference)  

    Web of Science

    researchmap

  • 精神疾患の経末梢的脳修復 GABAインターニューロン再生と社会コミュニケーションの回復

    鵜飼 渉, 小野 貴文, 白坂 知彦, 橋本 恵理, 吉永 敏弘, 石井 貴男, 渡邊 公彦, 渡邉 一平, 館農 勝, 齋藤 諭, 齋藤 利和

    精神薬療研究年報   42 ( 42 )   41 - 42   2010.3

     More details

    Language:Japanese   Publisher:(公財)先進医薬研究振興財団  

    Other Link:: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-22791132/

    CiNii Research

    Ichushi

    researchmap

  • Stem cell therapy-functional recovery in a neurodevelopmental model of schizophrenia

    E. Hashimoto, T. Ono, W. Ukai, T. Yoshinaga, T. Ishii, K. Watanabe, I. Watanabe, T. Shirasaka, M. Tateno, T. Saito

    INTERNATIONAL JOURNAL OF NEUROPSYCHOPHARMACOLOGY   13   219 - 220   2010

     More details

    Language:English   Publishing type:Research paper, summary (international conference)  

    Web of Science

    researchmap

  • Effects of psychotropics on ER stress and its potential implication for the clinical effect

    W. Ukai, E. Hashimoto, T. Ishii, T. Yoshinaga, M. Tateno, T. Ono, K. Watanabe, I. Watanabe, T. Saito

    INTERNATIONAL JOURNAL OF NEUROPSYCHOPHARMACOLOGY   13   30 - 30   2010

     More details

    Language:English   Publishing type:Research paper, summary (international conference)  

    Web of Science

    researchmap

  • Recovery of hindlimb hopping locomotor function after the spinal cord hemisection in rabbits

    Kiyoji Matsuyama, Takeshi Sasaki, Takao Ishii, Masanori Ishiguro, Takashi Nagamine

    JOURNAL OF PHYSIOLOGICAL SCIENCES   60   S153 - S153   2010

     More details

    Language:English   Publishing type:Research paper, summary (international conference)  

    Web of Science

    researchmap

  • Roles of nuclear receptor TLX in neural stem cell functions

    I. Watanabe, W. Ukai, T. Ono, K. Watanabe, T. Shirasaka, E. Hashimoto, T. Ishii, M. Tateno, T. Saito

    INTERNATIONAL JOURNAL OF NEUROPSYCHOPHARMACOLOGY   13   196 - 196   2010

     More details

    Language:English   Publishing type:Research paper, summary (international conference)  

    Web of Science

    researchmap

  • The change of brain-derived neurotrophic factor (BDNF) and tyrosine kinase B (TrkB) receptor on platelet in depression

    K. Watanabe, E. Hashimoto, W. Ukai, T. Ishii, T. Yoshinaga, M. Tateno, I. Watanabe, T. Shirasaka, H. Kaneta, Y. Kigawa, T. Saito

    INTERNATIONAL JOURNAL OF NEUROPSYCHOPHARMACOLOGY   13   163 - 163   2010

     More details

    Language:English   Publishing type:Research paper, summary (international conference)  

    Web of Science

    researchmap

  • アルコールによる脳障害に対する再生医療的アプローチの可能性

    橋本 恵理, 吉永 敏弘, 石井 貴男, 齋藤 諭, 鵜飼 渉, 齋藤 利和

    日本アルコール・薬物医学会雑誌   44 ( 6 )   674 - 679   2009.12

     More details

    Language:Japanese   Publisher:日本アルコール・薬物医学会  

    Ichushi

    researchmap

  • アルコール・薬物関連障害の生物学的研究の動向 アルコールによる脳神経ネットワークの変異 行動変化と分子メカニズムの解析から

    鵜飼 渉, 橋本 恵理, 石井 貴男, 白坂 知彦, 吉永 敏弘, 館農 勝, 小野 貴文, 渡邊 公彦, 渡邉 一平, 齋藤 利和

    日本アルコール・薬物医学会雑誌   44 ( 4 )   270 - 271   2009.8

     More details

    Language:Japanese   Publisher:日本アルコール・薬物医学会  

    Ichushi

    researchmap

  • エタノールによる神経幹細胞機能異常における攻撃性・衝動性関連因子の発現変化解析

    渡邉 一平, 鵜飼 渉, 小野 貴文, 渡邊 公彦, 白坂 知彦, 石井 貴男, 館農 勝, 橋本 恵理, 齋藤 利和

    日本アルコール・薬物医学会雑誌   44 ( 4 )   428 - 429   2009.8

     More details

    Language:Japanese   Publisher:日本アルコール・薬物医学会  

    Ichushi

    researchmap

  • 神経幹細胞移植はFASDモデルラットの社会行動異常を改善する

    白坂 知彦, 小野 貴文, 鵜飼 渉, 吉永 敏弘, 石井 貴男, 渡邊 公彦, 渡邉 一平, 館農 勝, 橋本 恵理, 齋藤 利和

    日本アルコール・薬物医学会雑誌   44 ( 4 )   282 - 283   2009.8

     More details

    Language:Japanese   Publisher:日本アルコール・薬物医学会  

    Ichushi

    researchmap

  • 【気分障害の神経心理学】 気分障害における神経回路網の修復再生と認知機能

    鵜飼 渉, 橋本 恵理, 石井 貴男, 吉永 敏弘, 渡邊 公彦, 小野 貴文, 館農 勝, 渡邉 一平, 白坂 智彦, 齋藤 利和

    臨床精神医学   38 ( 4 )   421 - 428   2009.4

     More details

    Language:Japanese   Publisher:(株)アークメディア  

    Ichushi

    researchmap

  • 精神疾患の脳神経回路修復 個別診断と薬物・細胞コンバインド療法の可能性の検討

    鵜飼 渉, 渡邊 公彦, 吉永 敏弘, 橋本 恵理, 小野 貴文, 石井 貴男, 館農 勝, 渡邉 一平, 白坂 智彦, 齋藤 利和

    精神薬療研究年報   ( 41 )   47 - 48   2009.3

     More details

    Language:Japanese   Publisher:(公財)先進医薬研究振興財団  

    Ichushi

    researchmap

  • Recovery of hindlimb locomotor function after spinal cord injury: A study using decerebrate animal models

    Kiyoji Matsuyama, Takao Ishii, Masanori Ishiguro

    NEUROSCIENCE RESEARCH   65   S166 - S167   2009

     More details

    Language:English   Publishing type:Research paper, summary (international conference)  

    DOI: 10.1016/j.neures.2009.09.868

    Web of Science

    researchmap

  • アルコールによる脳神経回路障害のメカニズムとその修復法の探索 神経細胞・神経幹細胞を用いたin vitro、in vivo解析

    鵜飼 渉, 石井 貴男, 吉永 敏弘, 館農 勝, 橋本 恵理, 小野 貴文, 渡邊 公彦, 渡邉 一平, 白坂 智彦, 齋藤 利和

    日本アルコール・薬物医学会雑誌   43 ( 6 )   763 - 769   2008.12

     More details

    Language:Japanese   Publisher:日本アルコール・薬物医学会  

    Ichushi

    researchmap

  • アルコール性精神障害に対する神経幹細胞移植療法の可能性に関する検討

    小野 貴文, 吉永 敏弘, 石井 貴男, 鵜飼 渉, 館農 勝, 渡邊 公彦, 渡邉 一平, 白坂 知彦, 齋藤 諭, 橋本 恵理, 齋藤 利和

    日本アルコール・薬物医学会雑誌   43 ( 4 )   416 - 417   2008.8

     More details

    Language:Japanese   Publisher:日本アルコール・薬物医学会  

    Ichushi

    researchmap

  • エタノールによる神経幹細胞機能異常におけるCREB/NRSF調節機構変化に関する解析

    鵜飼 渉, 石井 貴男, 橋本 恵理, 吉永 敏弘, 館農 勝, 小野 貴文, 渡邊 公彦, 渡邉 一平, 白坂 知彦, 齋藤 諭, 齋藤 利和

    日本アルコール・薬物医学会雑誌   43 ( 4 )   574 - 575   2008.8

     More details

    Language:Japanese   Publisher:日本アルコール・薬物医学会  

    Ichushi

    researchmap

  • New potential therapy of neural stem cell transplantation for repairing alcohol-induced brain damage

    T. Saito, E. Hashimoto, W. Ukai, T. Yoshinaga, T. Ishii, M. Tateno, S. Saito

    INTERNATIONAL JOURNAL OF NEUROPSYCHOPHARMACOLOGY   11   74 - 74   2008.7

     More details

    Language:English   Publishing type:Research paper, summary (international conference)  

    Web of Science

    researchmap

  • Possible new treatment of schizophrenia: A combined therapy of cells and drugs

    W. Ukai, E. Hashimoto, T. Yoshinaga, T. Ishii, M. Tateno, T. Ono, K. Watanabe, S. Saito, T. Saito

    INTERNATIONAL JOURNAL OF NEUROPSYCHOPHARMACOLOGY   11   267 - 267   2008.7

     More details

    Language:English   Publishing type:Research paper, summary (international conference)  

    Web of Science

    researchmap

  • The alteration of CREB/NRSF regulation in the neural stem cell dysfunction by ethanol

    W. Ukai, T. Ishii, T. Yoshinaga, M. Tateno, T. Ono, K. Watanabe, E. Hashimoto, S. Saito, Y. Mukai, T. Saito

    ALCOHOLISM-CLINICAL AND EXPERIMENTAL RESEARCH   32 ( 6 )   18A - 18A   2008.6

     More details

    Language:English   Publishing type:Research paper, summary (international conference)  

    Web of Science

    researchmap

  • Translational research of repairing therapy for the damaged brain by ethanol

    E. Hashimoto, W. Ukai, T. Yoshinaga, T. Ishii, M. Tateno, T. Ono, K. Watanabe, S. Saito, T. Saito

    ALCOHOLISM-CLINICAL AND EXPERIMENTAL RESEARCH   32 ( 6 )   277A - 277A   2008.6

     More details

    Language:English   Publishing type:Research paper, summary (international conference)  

    Web of Science

    researchmap

  • The common aspects of pathophysiology of alcoholism and depression

    M. Tateno, W. Ukai, T. Yoshinaga, T. Ishii, S. Saito, E. Hashimoto, T. Saito

    ALCOHOLISM-CLINICAL AND EXPERIMENTAL RESEARCH   32 ( 6 )   299A - 299A   2008.6

     More details

    Language:English   Publishing type:Research paper, summary (international conference)  

    Web of Science

    researchmap

  • アルコールによる脳神経回路網の異常 神経幹細胞を用いた修復の試み

    鵜飼 渉, 橋本 恵理, 吉永 敏弘, 石井 貴男, 館農 勝, 小野 貴文, 渡邊 公彦, 齋藤 諭, 齋藤 利和

    日本神経精神薬理学雑誌   28 ( 2 )   69 - 73   2008.4

     More details

    Language:Japanese   Publisher:(一社)日本神経精神薬理学会  

    Ichushi

    researchmap

  • Effect of lithium on ethanol-induced changes of neural differentiation

    T. Ishii, W. Ukai, T. Yoshinaga, T. Ono, M. Tateno, K. Watanabe, S. Saito, E. Hashimoto, T. Saito

    PSYCHIATRY AND CLINICAL NEUROSCIENCES   62 ( 1 )   S14 - S14   2008.2

     More details

    Language:English   Publishing type:Research paper, summary (international conference)  

    Web of Science

    researchmap

  • エタノールによる神経幹細胞の分化制御 小胞体機能に関わる分子変動の解析

    石井 貴男, 鵜飼 渉, 館農 勝, 吉永 敏弘, 小野 貴文, 渡邊 公彦, 齋藤 諭, 橋本 恵理, 齋藤 利和, 相馬 仁

    アルコールと医学生物学   27   16 - 23   2007.9

     More details

    Language:Japanese   Publisher:(株)響文社  

    Ichushi

    researchmap

  • Trichostatin Aは転写制御変化を介してアルコールによる神経新生異常を抑制する

    石井 貴男, 鵜飼 渉, 吉永 敏弘, 館農 勝, 橋本 恵理, 斉藤 諭, 齋藤 利和

    日本アルコール・薬物医学会雑誌   42 ( 4 )   420 - 421   2007.8

     More details

    Language:Japanese   Publisher:日本アルコール・薬物医学会  

    Ichushi

    researchmap

  • アルコール・薬物依存の基礎研究の動向 エタノールによる神経幹細胞機能異常の細胞内メカニズム解析

    鵜飼 渉, 石井 貴男, 吉永 敏弘, 館農 勝, 橋本 恵理, 齋藤 諭, 齋藤 利和

    日本アルコール・薬物医学会雑誌   42 ( 4 )   230 - 231   2007.8

     More details

    Language:Japanese   Publisher:日本アルコール・薬物医学会  

    Ichushi

    researchmap

  • 若手精神科医の立場から精神医療を考える 精神医療の現状と地域の抱える課題 東北・北海道地域から地域精神医療の可能性

    今村 弥生, 石井 貴男, 今井 智之, 菊地 紗耶, 橋本 直樹

    精神神経学雑誌   108 ( 9 )   957 - 960   2006.9

  • Neural stem cell transplantation for psychiatric disease using alcohol exposure model

    T. Yoshinaga, W. Ukai, T. Ishii, T. Imai, S. Kurosawa, E. Hashimoto, S. Saito, T. Saito

    INTERNATIONAL JOURNAL OF NEUROPSYCHOPHARMACOLOGY   9   S211 - S211   2006.7

     More details

    Language:English   Publishing type:Research paper, summary (international conference)  

    Web of Science

    researchmap

  • 【再発予防と精神科薬物療法】 アルコール依存の再発予防と精神科薬物療法

    石井 貴男, 鵜飼 渉, 齋藤 利和

    臨床精神薬理   9 ( 6 )   1177 - 1183   2006.6

     More details

    Language:Japanese   Publisher:(株)星和書店  

    Ichushi

    researchmap

  • The effects of antidepressants on the phenotype specific neuronal differentiation in vitro

    W. Ukai, T. Imai, T. Ishii, S. Kurosawa, T. Yoshinaga, T. Ono, S. Saito, E. Hashimoto, H. Ikeda, T. Saito

    JOURNAL OF PHARMACOLOGICAL SCIENCES   101   100 - 100   2006

     More details

    Language:English   Publishing type:Research paper, summary (international conference)  

    Web of Science

    researchmap

  • アルコールによる神経新生抑制における転写抑制因子NRSF/RESTの役割

    館農 勝, 鵜飼 渉, 石井 貴男, 橋本 恵理, 池田 官司, 齋藤 利和

    アルコールと医学生物学   25   43 - 50   2005.9

     More details

    Language:Japanese   Publisher:(株)響文社  

    Ichushi

    researchmap

  • アルコール・薬物依存の次世代への影響 幼若神経細胞を用いたエタノール誘発神経細胞発達変化の研究

    鵜飼 渉, 石井 貴男, 橋本 恵理, 池田 官司, 齋藤 利和

    日本アルコール・薬物医学会雑誌   40 ( 4 )   336 - 337   2005.8

     More details

    Language:Japanese   Publisher:日本アルコール・薬物医学会  

    Ichushi

    researchmap

  • 薬物乱用と依存メカニズム アルコール依存の機序に関する研究 エタノールの神経細胞及び神経幹細胞に及ぼす影響

    鵜飼 渉, 石井 貴男, 橋本 恵理, 齋藤 利和

    日本アルコール・薬物医学会雑誌   40 ( 4 )   304 - 305   2005.8

     More details

    Language:Japanese   Publisher:日本アルコール・薬物医学会  

    Ichushi

    researchmap

  • アルコールと細胞内情報伝達 エタノールによる神経幹細胞分化制御に対する向精神薬の影響

    石井 貴男, 鵜飼 渉, 橋本 恵理, 池田 官司, 齋藤 利和

    日本アルコール・薬物医学会雑誌   40 ( 4 )   286 - 287   2005.8

     More details

    Language:Japanese   Publisher:日本アルコール・薬物医学会  

    Ichushi

    researchmap

▼display all

Research Projects

  • Recovery of employment function in patients with schizophrenia: significance of enhancing brain neural circuits supporting sociality and empathy.

    Grant number:25K10871  2025.4 - 2028.3

    Japan Society for the Promotion of Science  Grants-in-Aid for Scientific Research  Grant-in-Aid for Scientific Research (C)

      More details

    Grant amount:\4550000 ( Direct Cost: \3500000 、 Indirect Cost:\1050000 )

    researchmap

  • Recovery of occupational functions in schizophrenia: significance of empathy behavior enhancement by synchronizer neuron activation

    Grant number:22K07600  2022.4 - 2025.3

    Japan Society for the Promotion of Science  Grants-in-Aid for Scientific Research Grant-in-Aid for Scientific Research (C)  Grant-in-Aid for Scientific Research (C)

      More details

    Grant amount:\4160000 ( Direct Cost: \3200000 、 Indirect Cost:\960000 )

    researchmap

  • 血小板のBDNF放出能の変化に着目した慢性疼痛とうつ病のバイオマーカー開発

    Grant number:22K07618  2022.4 - 2025.3

    日本学術振興会  科学研究費助成事業 基盤研究(C)  基盤研究(C)

    石井 貴男

      More details

    Grant amount:\3120000 ( Direct Cost: \2400000 、 Indirect Cost:\720000 )

    researchmap

  • Neural basis of recovery of social cognitive impairment in mental disorder: significance of enhancing for synchronizer neurons

    Grant number:19K08023  2019.4 - 2022.3

    Japan Society for the Promotion of Science  Grants-in-Aid for Scientific Research Grant-in-Aid for Scientific Research (C)  Grant-in-Aid for Scientific Research (C)

    Ukai Wataru

      More details

    Grant amount:\4290000 ( Direct Cost: \3300000 、 Indirect Cost:\990000 )

    First, we used animal model of schizophrenia produced by exposing rats to poly (I:C) during fetal period. We showed that treatment with a drug that has been reported to improve occupational and social dysfunction in schizophrenic patients in clinical practice recovered social behavior deficits in this model, involving the mechanism of increase in the number of parvalbumin (PV)-positive cells in the hippocampus and amygdala. Next, we conducted analysis of the molecular changes in the social/cognitive recovery, and found that treatment with the therapeutic drug increased PV and Bdnf long 3'UTR mRNA levels in the dorsal hippocampus, and that these were strongly implicated in the onset, pathogenesis, and treatment response of developmental stress-related schizophrenia.

    researchmap

  • Social function recovery in schizophrenia: brain mechanism of empathy/concerning function using stem cells and oxytocin

    Grant number:26461724  2014.4 - 2017.3

    Japan Society for the Promotion of Science  Grants-in-Aid for Scientific Research Grant-in-Aid for Scientific Research (C)  Grant-in-Aid for Scientific Research (C)

    Ukai Wataru, Iwamoto Kazuya, Morimoto Takafumi

      More details

    Grant amount:\4940000 ( Direct Cost: \3800000 、 Indirect Cost:\1140000 )

    First, we analyzed the social functioning behavior of model animals administered with stem cells and the distribution of cells in the brain. We detected that the patient-derived stem cells was difficult to become GAD67 and Parvalbumin-positive GABA interneurons in the brain after administration, and social interaction behavior was decreased in the patient-derived stem cell administered group compared to the control and healthy-derived stem cell administered group. Next, the synapse forming ability of the GABAergic interneuron was analyzed by the actin motility of the precursor structure filopodia, and found the reduction of the filopodia movement in the patient-derived cells. We also found that the possibility of the influence of decreased expression of the transcription factor TBX1 against it.

    researchmap

  • The develpoment of biological marker for alcohol-induced mood disorders: focusing on the functional alteration of platelet and neural stem cell

    Grant number:25461737  2013.4 - 2016.3

    Japan Society for the Promotion of Science  Grants-in-Aid for Scientific Research Grant-in-Aid for Scientific Research (C)  Grant-in-Aid for Scientific Research (C)

    ISHII Takao, HASHIMOTO ERI, MATSUYAMA KIYOJI, UKAI WATARU, SOUMA HITOSHI

      More details

    Grant amount:\4810000 ( Direct Cost: \3700000 、 Indirect Cost:\1110000 )

    In this study, we investigated the common pathophysiology of alcohol-induced brain damage and mood disorders, focusing on the functional alteration of platelet and neural stem cell. We examine the effects of ethanol and antidepressants on the platelet BDNF release. Ethanol suppressed platelet BDNF release and the promotive effect of antidepressant on BDNF release. Furthermore, we investigated the transfer of BDNF derived from serum (or platelet) to the brain using fluorescent-labeled BDNF. We have detected BDNF-FITC in the cells at dentate gyrus in the hippocampus in which adult neurogenesis occurs.

    researchmap

  • 転写因子活性に着目したアルコール依存症とうつ病の新規治療マーカーの開発

    Grant number:21791138  2009 - 2010

    日本学術振興会  科学研究費助成事業 若手研究(B)  若手研究(B)

    石井 貴男

      More details

    Grant amount:\4030000 ( Direct Cost: \3100000 、 Indirect Cost:\930000 )

    本研究では、精神疾患の病態解明、さらには新たな診断、治療への応用の可能性を念頭に、種々の薬剤を処置した神経幹細胞における神経新生に関連する転写因子(CREBおよびNRSF)活性の解析を行った。神経幹細胞は胎齢13.5日のラット胎仔より取り出し、単層培養法を改良した方法で得た。神経幹細胞から神経細胞への分化機能の評価は,抗MAP2抗体陽性強度をELISA法にて定量化する方法で行った。転写因子の解析については、Western blotting法およびGel Shiftアッセイを応用したNo Shift法にて評価を行った。今回の研究では、種々の脳障害を引き起こすことが知られているエタノールと神経新生促進作用が知られている各種抗うつ薬を用いて検討を行った。エタノールは、神経幹細胞の生存に影響を与えない濃度において、神経幹細胞から神経細胞への分化を抑制した。一方、各種抗うつ薬はこのエタノールの神経分化抑制を軽減させる作用を示した。次に、転写因子CREBの変化を調べた。神経幹細胞にエタノールを処置することによって、細胞分化に大きな役割をもつCREBの活性低下(リン酸化CBEBの減弱)が観察された。また、抗うつ薬のうち,Amitriptyline、およびSertralineはリン酸化CREB活性を増加させる作用を示した。一方、FluoxetineおよびParoxetineは、アルコールによって減弱したリン酸化CREB活性に影響を及ぼさなかった。神経遺伝子転写抑制因子であるNRSFは、エタノールの処置により活性が増加した。抗うつ薬のうち、Fluoxetine, Paroxetine、およびSertralineはNRSF活性を低下させる作用を示したが、Amitriptylineはアルコールによって増加したNRSF活性に影響を及ぼさなかった。これらの結果より、抗うつ薬がエタノールの神経幹細胞分化機能障害を改善させる機序として、神経幹細胞内の転写因子CREB系の変化に加え,神経遺伝子転写抑制因子NRSFの活性調節機構変化の重要性が考えられた。加えて,各抗うつ薬が作用する転写因子のキャラクター解析から、CREB系の促進を主体とするタイプ、あるいはNRSFの抑制を主体とするタイプが存在する可能性が考えられた。

    researchmap

  • The common pathophygiology of alcoholism and depression- neural stem cell dysfunction induced by impairment of endoplasmic reticulum

    Grant number:19790823  2007 - 2008

    Japan Society for the Promotion of Science  Grants-in-Aid for Scientific Research Grant-in-Aid for Young Scientists (B)  Grant-in-Aid for Young Scientists (B)

    ISHII Takao

      More details

    Grant amount:\3520000 ( Direct Cost: \3100000 、 Indirect Cost:\420000 )

    researchmap

▼display all