SASAKI Takeshi

写真a

Affiliation

School of Health Science, Department of Physical Therapy, First Division of Physical Therapy

Job title

Lecturer
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Degree 【 display / non-display 】

  • 博士（理学療法学）

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Research Experience 【 display / non-display 】

  • 2015
    -
    Now

    Sapporo Medical University   School of Health Sciences, Department of Physical Therapy   講師

    講師

  • 2008
    -
    2014

    Sapporo Medical University   School of Health Sciences, Department of Physical Therapy   助教

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Professional Memberships 【 display / non-display 】

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    THE JAPAN NEUROSCIENCE SOCIETY

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    JAPANESE PHYSICAL THERAPY ASSOCIATION

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    THE PHYSIOLOGICAL SOCIETY OF JAPAN

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    JAPANESE SOCIETY OF PUBLIC HEALTH

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Research Areas 【 display / non-display 】

  • Life sciences   Rehabilitation science  

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Affiliation 【 display / non-display 】

  • Sapporo Medical University   School of Health Sciences   講師  

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Research Interests 【 display / non-display 】

  • 脳損傷

  • 動物実験

  • 姿勢調節

  • 重心動揺

  • 運動系神経生理学

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Papers 【 display / non-display 】

  • Development of the Self-Assessment Self-Disclosure Questionnaire to Examine the Association between Self-Disclosure and Frailty among Community-Dwelling Older Adults in Japan

    Kazuki Yokoyama, Hikaru Ihira, Yuriko Matsuzaki-Kihara, Atsushi Mizumoto, Hideyuki Tashiro, Kiyotaka Shimada, Kosuke Yama, Ryo Miyajima, Takeshi Sasaki, Naoki Kozuka, Nozomu Ikeda

    Geriatrics ( MDPI AG )  9 ( 3 ) 67 - 67  2024.05  [Refereed]

    　View Summary

    Self-disclosure is the attitude of communicating one’s experiences and condition to others and is an indicator of mental health and an open personality. Frailty, characterized by reduced physical and psychological resistance, predicts the incidence of dependency and mortality. Although low self-disclosure may be associated with frailty, there is no scale to measure older adults’ self-disclosure. This cross-sectional study assessed the validity of a self-assessment self-disclosure questionnaire and examined the association between the content of self-disclosures to friends and acquaintances and frailty among community-dwelling older adults. A total of 237 adults aged ≥65 in Japan were surveyed using a mailed self-administered questionnaire in 2021. The self-disclosure scale consisted of 10 items and showed adequate validity. Participants were classified into a robust group (n = 117, women 57.3%) and a frailty group (n = 120, women 73.3%) using the Kihon Checklist. After adjusting for covariates, multivariate-adjusted logistic regression models revealed frailty was associated with lower self-disclosure of recent positive events, motivation and strengths (indicating strong points) in life, relationships with family and relatives, experiences of work and social activities, and financial status. The proposed questionnaire must still be further tested in other populations, but our initial results may contribute to preventing frailty and improving mental health among community-dwelling older adults.

    DOI

  • 脳卒中後アパシーによる身体活動量の減少が病棟歩行自立時期に及ぼす影響 アパシー症例と非アパシー症例の比較による検討

    小菅 凜, 工藤 哲史, 赤岩 眞悠, 佐々木 健史, 古田 亮一, 菅原 和広

    総合リハビリテーション ( (株)医学書院 )  52 ( 3 ) 283 - 287  2024.03  [Refereed]

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    ＜文献概要＞脳卒中患者に生じるアパシー(post-stroke apathy:PSA)は,日常生活動作(activities of daily living:ADL)の回復不良に影響する.歩行能力の回復は自宅退院に向けたリハビリテーション目標としてADLのなかでも特に重要である.本報告では脳卒中患者2症例を経時的に追跡し,PSAが病棟歩行自立に及ぼす影響について検討した.対象は病棟歩行自立の時期が約1ヵ月異なる2症例で,1症例目は発症から退院までPSAを認め,2症例目では同期間でPSAを認めなかった.PSA症例は非PSA症例と比較して歩行自立水準に至るまで期間を要した.その要因として,歩行自立時における歩行評価によって下肢筋力低下,運動耐容能低下や歩行量不足が考えられた.PSAによって病棟での身体活動量が減少し,運動耐容能や筋力の低下などの二次合併症の発生による歩行量の増加不良が生じたため,結果的に病棟歩行自立が遅延したことが文献的考察より示唆された.

  • Does 20 Hz Transcranial Alternating Current Stimulation over the Human Primary Motor Cortex Modulate Beta Rebound Following Voluntary Movement?

    Mayu Akaiwa, Yuya Matsuda, Ryo Kurokawa, Yasushi Sugawara, Rin Kosuge, Hidekazu Saito, Eriko Shibata, Takeshi Sasaki, Kazuhiro Sugawara, Naoki Kozuka

    Brain sciences   14 ( 1 )  2024.01  [Refereed]  [International journal]

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    Beta frequency oscillations originating from the primary motor cortex increase in amplitude following the initiation of voluntary movement, a process termed beta rebound. The strength of beta rebound has been reported to predict the recovery of motor function following stroke, suggesting therapeutic applications of beta rebound modulation. The present study examined the effect of 20 Hz transcranial alternating current stimulation (tACS) on the beta rebound induced by self-paced voluntary movement. Electroencephalograms (EEGs) and electromyograms (EMGs) were recorded from 16 healthy adults during voluntary movements performed before and after active or sham tACS. There was no significant change in average beta rebound after active tACS. However, the beta rebound amplitude was significantly enhanced in a subset of participants, and the magnitude of the increase across all participants was negatively correlated with the difference between individual peak beta frequency and tACS frequency. Thus, matching the stimulus frequency of tACS with individual beta frequency may facilitate therapeutic enhancement for motor rehabilitation.

    DOI PubMed

  • Event-Related Brain Potentials N140 and P300 during Somatosensory Go/NoGo Tasks Are Modulated by Movement Preparation.

    Yuya Matsuda, Yasushi Sugawara, Mayu Akaiwa, Hidekazu Saito, Eriko Shibata, Takeshi Sasaki, Kazuhiro Sugawara

    Brain sciences   14 ( 1 )  2023.12  [Refereed]  [International journal]

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    The Go/NoGo task requires attention and sensory processing to distinguish a motor action cue or 'Go stimulus' from a 'NoGo stimulus' requiring no action, as well as motor preparation for a rapid Go stimulus response. The neural activity mediating these response phases can be examined non-invasively by measuring specific event-related brain potentials (ERPs) using electroencephalography. However, it is critical to determine how different task conditions, such as the relationship between attention site and movement site, influence ERPs and task performance. In this study, we compared attention-associated ERP components N140 and P300, the performance metrics reaction time (RT) and accuracy (%Error) and movement-related cortical potentials (MRCPs) between Go/NoGo task trials in which attention target and movement site were the same (right index finger movement in response to right index finger stimulation) or different (right index finger movement in response to fifth finger stimulation). In other Count trials, participants kept a running count of target stimuli presented but did not initiate a motor response. The N140 amplitudes at electrode site Cz were significantly larger in Movement trials than in Count trials regardless of the stimulation site-movement site condition. In contrast, the P300 amplitude at Cz was significantly smaller in Movement trials than in Count trials. The temporal windows of N140 and P300 overlapped with the MRCP. This superposition may influence N140 and P300 through summation, possibly independent of changes in attentional allocation.

    DOI PubMed

  • Movement of the stimulated finger in a Go/NoGo task enhances attention directed to that finger as evidenced by P300 amplitude modulation.

    Kazuhiro Sugawara, Mayu Akaiwa, Yuya Matsuda, Eriko Shibata, Hidekazu Saito, Takeshi Sasaki

    Frontiers in human neuroscience   17   1178509 - 1178509  2023  [International journal]

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    Somatosensory cues and the optimal allocation of attentional resources are critical for motor performance, but it is uncertain how movement of a body part modulates directed attention and the processing of somatosensory signals originating from that same body part. The current study measured motor reaction time (RT) and the P300 event-related potential during a required movement response to stimulation of the same body part in a Go/NoGo task under multiple response. In the Movement Condition, participants were instructed to extend their right index finger in response to mild electrical stimulation of the same finger (Go signal) or remain still when receiving electrical stimulation to the fifth right finger (NoGo signal). Movement RTs and P300 amplitudes and latencies were measured under varying Go signal 50% probabilities. In other trial blocks, participants were required to count Go signals but not respond with movement or to ignore all signals while engaged in an unrelated task. Mean RT in the Movement Condition was 234.5 ms. P300 response amplitudes at midline electrodes (Fz, Cz, Pz) were the largest in the Movement Condition. The P300 amplitude at parietal electrode site Pz was significantly greater during Movement Condition trials than during Count Condition trials. The increase in P300 amplitude during trials requiring movement of the same body part receiving somatosensory stimulation suggests that movement itself modulates the attentional resources allocated to that body part.

    DOI PubMed

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Misc 【 display / non-display 】

  • ラット大脳皮質感覚運動野および小脳虫部損傷による姿勢調節障害の特徴

    佐々木 健史, 長峯 隆, 松山 清治

    日本生理学雑誌 ( (一社)日本生理学会 )  78 ( 4 ) 65 - 66  2016.07

  • 脳幹歩行中枢と網様体脊髄路・赤核脊髄路

    松山清治, 佐々木健史

    Clinical Neuroscience   33 ( 7 ) 753 - 757  2015  [Invited]

  • 歩行運動と姿勢制御

    MATSUYAMA KIYOJI, SASAKI TAKESHI

    日本ボバース研究会学術大会誌   4th   17  2014.06

    J-GLOBAL

  • ラット姿勢調節反応の特徴 小動物用重心動揺計を用いた検討

    佐々木 健史, 長峯 隆, 松山 清治

    日本生理学雑誌 ( (一社)日本生理学会 )  76 ( 2 ) 81 - 82  2014.03

  • 小児の先天性障害による足部障害の機能解剖学的病態把握と理学療法

    小塚直樹, 西部寿人, 横井裕一郎, 佐々木健史, 松山敏勝

    理学療法 ( (株)メディカルプレス )  31 ( 2 ) 175 - 183  2014  [Refereed]  [Invited]

    Article, review, commentary, editorial, etc. (scientific journal)  

    　View Summary

    1.小児の先天性足部障害を機能解剖の視点から捉えることは特に立位・歩行に取り組む上で重要であり、脳性麻痺、二分脊椎、先天性筋強直性ジストロフィーの症例を供覧し、足部変形を中心に述べた。2.基礎疾患の病態を踏まえた足関節・足部の評価が重要であり、発達に伴う変化を観察する必要がある。3.変形の治療に際しては、機能解剖学的解析を慎重に行い、運動療法から保存療法、観血療法へと段階的に進める必要がある。(著者抄録)

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Research Projects 【 display / non-display 】

  • 随意運動に知覚変動の神経基盤解明と知覚コントロールを目指した運動プログラムの構築

    基盤研究(C)

    Project Year :

    2024.04
    -
    2028.03
     

    佐々木 健史, 菅原 和広, 齊藤 秀和

  • Characteristics of postural control disturbances in rats with or without brain lesion

    Grant-in-Aid for Challenging Exploratory Research

    Project Year :

    2011
    -
    2013
     

    SASAKI Takeshi, MATSUYAMA Kiyoji

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    This study aimed to investigate the characteristics of the postural control in rats with or without lesion of sensorimotor cortex (SMC). For this purpose, we developed a novel posturography technique to measure changes of center of pressure (COP) of small animals including rats during inclination of a floor surface at different angle velocities and in antero-posterior and left-right directions. In some animals, fore- and hind-limb extensor EMGs were measured simultaneously together with COP changes during floor inclination. Rats exhibited dynamic COP changes and phasic EMG activities along with increase of floor inclination. However, rats with lesion of SMC showed different patterns of postural change and uncoordinated EMG activities. This indicated that rats exhibited dynamic postural adjustments in response to postural perturbation and also indicated that this postural adjustment was impaired by lesion of SMC.

  • Neural mechanisms of functional recovery of hindlimb locomotion after the spinal cord injury in quadrupeds

    Grant-in-Aid for Scientific Research (C)

    Project Year :

    2007
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    2008
     

    MATSUYAMA Kiyoji, ISHIGURO Masanori, SASAKI Takeshi

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    本研究では中枢部分損傷後の歩行機能回復の神経機序解明を目的とし、下部胸髄半切断を施した除脳ウサギ歩行標本を用いて解析を進めた。この結果、脊髄半切断急性期には脊髄健常側後肢のみに歩行運動が誘発されたが、半切約1週間後には両側後肢に誘発されることを見出した。脳幹-脊髄歩行神経機構における歩行駆動信号の伝達経路の同定や末梢感覚フィードバックの機能的役割に関する解析から、脊髄半切断後の歩行機能回復は、時間経過に伴って脳幹下行性系と脊髄神経機構に生じる可塑性変化による可能性が示唆された。

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Presentations 【 display / non-display 】

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