佐々木 健史 (ササキ タケシ)

写真a

所属

保健医療学部 理学療法学科 理学療法学第一講座

職名

講師

学位 【 表示 / 非表示

  • 博士(理学療法学)

経歴 【 表示 / 非表示

  • 2015年
    -
    継続中

    札幌医科大学   保健医療学部 理学療法学科   講師

    講師

  • 2011年
    -
    2014年

    札幌医科大学   保健医療学部 理学療法学科   助教

    助教

所属学協会 【 表示 / 非表示

  •  
     
     

    日本神経科学学会

  •  
     
     

    日本理学療法士協会

  •  
     
     

    日本生理学会

  •  
     
     

    日本公衆衛生学会

研究分野 【 表示 / 非表示

  • ライフサイエンス   リハビリテーション科学  

researchmapの所属 【 表示 / 非表示

  • 札幌医科大学   保健医療学部   講師  

 

研究キーワード 【 表示 / 非表示

  • 脳損傷

  • 動物実験

  • 姿勢調節

  • 重心動揺

  • 運動系神経生理学

論文 【 表示 / 非表示

  • Does 20 Hz Transcranial Alternating Current Stimulation over the Human Primary Motor Cortex Modulate Beta Rebound Following Voluntary Movement?

    Mayu Akaiwa, Yuya Matsuda, Ryo Kurokawa, Yasushi Sugawara, Rin Kosuge, Hidekazu Saito, Eriko Shibata, Takeshi Sasaki, Kazuhiro Sugawara, Naoki Kozuka

    Brain sciences   14 ( 1 )  2024年01月  [査読有り]  [国際誌]

     概要を見る

    Beta frequency oscillations originating from the primary motor cortex increase in amplitude following the initiation of voluntary movement, a process termed beta rebound. The strength of beta rebound has been reported to predict the recovery of motor function following stroke, suggesting therapeutic applications of beta rebound modulation. The present study examined the effect of 20 Hz transcranial alternating current stimulation (tACS) on the beta rebound induced by self-paced voluntary movement. Electroencephalograms (EEGs) and electromyograms (EMGs) were recorded from 16 healthy adults during voluntary movements performed before and after active or sham tACS. There was no significant change in average beta rebound after active tACS. However, the beta rebound amplitude was significantly enhanced in a subset of participants, and the magnitude of the increase across all participants was negatively correlated with the difference between individual peak beta frequency and tACS frequency. Thus, matching the stimulus frequency of tACS with individual beta frequency may facilitate therapeutic enhancement for motor rehabilitation.

    DOI PubMed

  • Event-Related Brain Potentials N140 and P300 during Somatosensory Go/NoGo Tasks Are Modulated by Movement Preparation.

    Yuya Matsuda, Yasushi Sugawara, Mayu Akaiwa, Hidekazu Saito, Eriko Shibata, Takeshi Sasaki, Kazuhiro Sugawara

    Brain sciences   14 ( 1 )  2023年12月  [査読有り]  [国際誌]

     概要を見る

    The Go/NoGo task requires attention and sensory processing to distinguish a motor action cue or 'Go stimulus' from a 'NoGo stimulus' requiring no action, as well as motor preparation for a rapid Go stimulus response. The neural activity mediating these response phases can be examined non-invasively by measuring specific event-related brain potentials (ERPs) using electroencephalography. However, it is critical to determine how different task conditions, such as the relationship between attention site and movement site, influence ERPs and task performance. In this study, we compared attention-associated ERP components N140 and P300, the performance metrics reaction time (RT) and accuracy (%Error) and movement-related cortical potentials (MRCPs) between Go/NoGo task trials in which attention target and movement site were the same (right index finger movement in response to right index finger stimulation) or different (right index finger movement in response to fifth finger stimulation). In other Count trials, participants kept a running count of target stimuli presented but did not initiate a motor response. The N140 amplitudes at electrode site Cz were significantly larger in Movement trials than in Count trials regardless of the stimulation site-movement site condition. In contrast, the P300 amplitude at Cz was significantly smaller in Movement trials than in Count trials. The temporal windows of N140 and P300 overlapped with the MRCP. This superposition may influence N140 and P300 through summation, possibly independent of changes in attentional allocation.

    DOI PubMed

  • Movement of the stimulated finger in a Go/NoGo task enhances attention directed to that finger as evidenced by P300 amplitude modulation.

    Kazuhiro Sugawara, Mayu Akaiwa, Yuya Matsuda, Eriko Shibata, Hidekazu Saito, Takeshi Sasaki

    Frontiers in human neuroscience   17   1178509 - 1178509  2023年  [国際誌]

     概要を見る

    Somatosensory cues and the optimal allocation of attentional resources are critical for motor performance, but it is uncertain how movement of a body part modulates directed attention and the processing of somatosensory signals originating from that same body part. The current study measured motor reaction time (RT) and the P300 event-related potential during a required movement response to stimulation of the same body part in a Go/NoGo task under multiple response. In the Movement Condition, participants were instructed to extend their right index finger in response to mild electrical stimulation of the same finger (Go signal) or remain still when receiving electrical stimulation to the fifth right finger (NoGo signal). Movement RTs and P300 amplitudes and latencies were measured under varying Go signal 50% probabilities. In other trial blocks, participants were required to count Go signals but not respond with movement or to ignore all signals while engaged in an unrelated task. Mean RT in the Movement Condition was 234.5 ms. P300 response amplitudes at midline electrodes (Fz, Cz, Pz) were the largest in the Movement Condition. The P300 amplitude at parietal electrode site Pz was significantly greater during Movement Condition trials than during Count Condition trials. The increase in P300 amplitude during trials requiring movement of the same body part receiving somatosensory stimulation suggests that movement itself modulates the attentional resources allocated to that body part.

    DOI PubMed

  • Effects of repetitive practice of motor tasks on somatosensory gating.

    Mayu Akaiwa, Yuya Matsuda, Hidekazu Saito, Eriko Shibata, Takeshi Sasaki, Kazuhiro Sugawara

    Frontiers in human neuroscience   17   1131986 - 1131986  2023年  [査読有り]  [国際誌]

     概要を見る

    INTRODUCTION: During voluntary muscle contraction, the amplitude of the somatosensory evoked potential (SEP) is reduced by inhibiting sensory information from a peripheral nerve supplying the contracted muscle. This phenomenon is called "gating." We reported that participants with good motor skills indicated strong suppression of somatosensory information. The present study investigated the effects of motor performance improvement following repetitive practice on the SEP amplitude. METHODS: The ball rotation task (BR task) was practiced by 15 healthy participants repetitively. SEPs were recorded before (pre) and after (post) repetitive practice. RESULTS: The BR task performance was significantly improved and the required muscle activation to perform the task was significantly reduced after the repetitive practice. The degree of gating was not significant between pre and post- for the SEP amplitude. A significant correlation was found between changes in SEP amplitude from pre to post and performance improvement. DISCUSSION: After repetitive practice, the degree of gating did not change, but the performance of the BR task improved, and the muscle activity required for the BR task decreased. These results suggest that repetitive practice does not change the degree of gating but changes the mechanism of gating. Furthermore, they indicate that suppression of the somatosensory area may play a role in improving task performance.

    DOI PubMed

  • The relationships between motor behavior and sensory gating in the ball rotation task.

    Mayu Akaiwa, Yuya Matsuda, Yuta Soma, Eriko Shibata, Hidekazu Saito, Takeshi Sasaki, Kazuhiro Sugawara

    Experimental brain research   240 ( 10 ) 2659 - 2666  2022年10月  [査読有り]  [国際誌]

     概要を見る

    During voluntary muscle contraction, sensory information induced by electrostimulation of the nerves supplying the contracting muscle is inhibited and the amplitude of the corresponding somatosensory evoked potential (SEP) decreases. This phenomenon is called "gating." The reduction of the SEP amplitude is reportedly significantly larger when task performance is high. However, the relationship between dexterous movement skills and gating remains unclear. In this study, we investigated through a ball rotation (BR) task how dexterous movement skills affect the SEP amplitudes. Thirty healthy subjects performed the BR task comprising the rotation of two wooden balls as quickly as possible. We estimated the median number of ball rotations for each participant and classified the participants into two (fast and slow) groups based on the results. Moreover, we recorded SEPs, while the subjects performed BR tasks or rested. SEP amplitude reduction (P45) was significantly larger in the fast than in the slow group. We also observed that the P45 amplitude during the BR task was attenuated even more so in the case of the participants with better dexterous movement skills. Our results suggest that the participants with better dexterous movement skills might display stronger somatosensory information suppression because of increasing the motor cortex activity and the afferent input during the BR task.

    DOI PubMed

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Misc 【 表示 / 非表示

  • 運動課題の反復練習が体性感覚gatingに及ぼす影響

    赤岩眞悠, 松田裕弥, 齊藤秀和, 柴田恵理子, 佐々木健史, 菅原和広

    基礎理学療法学(Web)   25 ( Supplement )  2022年

    J-GLOBAL

  • 体性感覚刺激を用いたOddball課題中のN140は運動によって変調する

    松田裕弥, 菅原靖, 赤岩眞悠, 齊藤秀和, 柴田恵理子, 佐々木健史, 菅原和広

    基礎理学療法学(Web)   25 ( Supplement )  2022年

    J-GLOBAL

  • 運動パフォーマンスと体性感覚入力抑制の関係

    赤岩眞悠, 岩田昴樹, 齊藤秀和, 柴田恵理子, 佐々木健史, 菅原和広

    基礎理学療法学(Web)   24 ( Supplement )  2021年

    J-GLOBAL

  • ラット大脳皮質感覚運動野および小脳虫部損傷による姿勢調節障害の特徴

    佐々木 健史, 長峯 隆, 松山 清治

    日本生理学雑誌 ( (一社)日本生理学会 )  78 ( 4 ) 65 - 66  2016年07月

  • 脳幹歩行中枢と網様体脊髄路・赤核脊髄路

    松山清治, 佐々木健史

    Clinical Neuroscience   33 ( 7 ) 753 - 757  2015年  [招待有り]

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共同研究・競争的資金等の研究課題 【 表示 / 非表示

  • 中枢損傷部位の違いによる姿勢調節障害パターンの特定と有効なリハビリ介入方法の探索

    挑戦的萌芽研究

    研究期間:

    2011年
    -
    2013年
     

    佐々木 健史, 松山 清治

     研究概要を見る

    本研究では、ラットの姿勢調節反応の特徴を抽出するため、新たな小動物用重心動揺計を開発し、傾斜外乱時の重心変動と四肢筋活動について健常及び脳損傷モデルを用いて検討した。床面の異なる傾斜方向と傾斜速度による影響を調査した結果、健常モデルでは傾斜角度の増加に伴う四肢筋活動と傾斜反対側への体重移動による姿勢補正がみられ、この反応パターンは傾斜速度の増加に伴い変化した。一方、片側感覚-運動野損傷モデルでは麻痺肢の反応遅延と健側肢及び体幹による代償がみられ、傾斜速度の増加に伴い姿勢調節障害は顕著となった。以上より、本研究の手法を用いることで種々の中枢損傷に伴う姿勢調節機能の評価が可能になると考えられた。

  • 歩行機能回復に作用する中枢歩行制御システムの神経可塑性の解明

    基盤研究(C)

    研究期間:

    2007年
    -
    2008年
     

    松山 清治, 石黒 雅敬, 佐々木 健史

     研究概要を見る

    本研究では中枢部分損傷後の歩行機能回復の神経機序解明を目的とし、下部胸髄半切断を施した除脳ウサギ歩行標本を用いて解析を進めた。この結果、脊髄半切断急性期には脊髄健常側後肢のみに歩行運動が誘発されたが、半切約1週間後には両側後肢に誘発されることを見出した。脳幹-脊髄歩行神経機構における歩行駆動信号の伝達経路の同定や末梢感覚フィードバックの機能的役割に関する解析から、脊髄半切断後の歩行機能回復は、時間経過に伴って脳幹下行性系と脊髄神経機構に生じる可塑性変化による可能性が示唆された。

講演・口頭発表等 【 表示 / 非表示

  • 体性感覚刺激を用いたOddball課題中のN140は運動によって変調する

    松田裕弥, 菅原靖, 赤岩眞悠, 齊藤秀和, 柴田恵理子, 佐々木健史, 菅原和広

    基礎理学療法学(Web)  

    発表年月: 2022年

    開催年月日:
    2022年
     
     
  • 運動間隔10秒以上の自己ペース運動時の事象関連脱同期の出現

    菅原和広, 菅原和広, 齊藤秀和, 齊藤秀和, 赤岩眞悠, 佐々木健史, 佐々木健史, 臼井桂子, 松橋眞生, 白石秀明, 長峯隆

    臨床神経生理学(Web)  

    発表年月: 2022年

    開催年月日:
    2022年
     
     
  • 運動課題の反復練習が体性感覚gatingに及ぼす影響

    赤岩眞悠, 松田裕弥, 齊藤秀和, 柴田恵理子, 佐々木健史, 菅原和広

    基礎理学療法学(Web)  

    発表年月: 2022年

    開催年月日:
    2022年
     
     
  • 運動様式の違いが感覚運動野領域のβ帯域脳律動に及ぼす影響

    菅原和広, 菅原和広, 齊藤秀和, 齊藤秀和, 赤岩眞悠, 佐々木健史, 佐々木健史, 臼井桂子, 松橋眞生, 白石秀明, 長峯隆

    基礎理学療法学(Web)  

    発表年月: 2022年

    開催年月日:
    2022年
     
     
  • 運動パフォーマンスと体性感覚入力抑制の関係

    赤岩眞悠, 岩田昴樹, 齊藤秀和, 柴田恵理子, 佐々木健史, 菅原和広

    基礎理学療法学(Web)  

    発表年月: 2021年

    開催年月日:
    2021年
     
     

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