Details of a Researcher - NAGAISHI Kanna

Ultrasound-assisted middle thoracic epidural catheter placement utilizing the most dorsal sites of bilateral transverse process roots as anatomical landmarks: A cadaveric observational study and a clinical randomized controlled trial.

Tatsuya Kunigo, Yusuke Yoshikawa, Shunichi Niki, Masahiro Ohtani, Mami Muraki, Asako Nitta, Yuki Ohsaki, Kanna Nagaishi, Michiaki Yamakage

Journal of clinical anesthesia 101 111740 - 111740 2025.01 [International journal]

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STUDY OBJECTIVE: We developed an innovative method for ultrasound-assisted thoracic epidural catheter placement and assessed its potential to reduce procedural duration for trainees. DESIGN: A cadaveric observational study and a clinical randomized controlled trial. SETTING: Sapporo Medical University Hospital. PATIENTS: A total of 52 adult patients scheduled for thoracic or abdominal surgery and four cadavers. INTERVENTIONS: Patients were randomly assigned to either group receiving conventional palpation (conventional group) or combination of the ultrasound examination and conventional palpation (ultrasound group). MEASUREMENTS: The primary outcome was total procedure time (sum of skin marking time and needling time) by trainees. The secondary outcomes were (1) skin marking time, (2) needling time, (3) multiple skin punctures, (4) needle redirection, (5) complications, and (6) failed cases. MAIN RESULTS: Through dissection of four cadavers, the most dorsal site of the transverse process root was identifiable by ultrasound and the reliable indicator of the interlaminar space. We devised ultrasound-assisted middle thoracic epidural catheter placement utilizing the most dorsal sites of bilateral transverse process roots as anatomical landmarks. Trainees in the ultrasound group had significantly longer skin marking time and significantly shorter needling time than those in the conventional group (107 [87-158] vs 46 s [34-54] s, p < 0.001 and 197 [156-328] vs 341 [303-488] s, p = 0.003). Consequently, there was no significant difference between the two groups in total procedure time (326 [263-467] s vs 391 [354-533] s, p = 0.167). Moreover, the probability of trainee failure in epidural anesthesia was significantly lower in the ultrasound group (2/26 [17.7 %] vs 10/26 [38.5 %], p = 0.019). CONCLUSIONS: Our novel technique for thoracic epidural catheter placement resulted in expedited needling and enhanced success rates among trainees, although there was no significant difference between total procedure time when using ultrasound guidance and that when using conventional palpation.

DOI PubMed
Self-suppressing behavioral patterns and depressive traits exacerbate chronic pain: Psychological trait assessment using the structured association technique method.

Shin Hashizume, Masako Nakano, Chihiro Ikehata, Nobuaki Himuro, Kanna Nagaishi, Mineko Fujimiya

PloS one 20 ( 3 ) e0319647 2025 [International journal]

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This study investigated the relationship between psychological traits and chronic pain using the Structured Association Technique (SAT) method to evaluate psychological factors associated with chronic pain. The participants included 105 older adults (23 men, 82 women, mean age 80.82 years) who received rehabilitation services. Chronic pain severity was assessed using a numerical rating scale (NRS), and psychological traits were evaluated by SAT. In addition, maternal attachment experiences in childhood were examined. The NRS showed significant positive correlations with the self-suppressing behavioral pattern (S) scale (r = 0.31, p = 0.001), and the depression (D) scale (r = 0.31, p = 0.001). The proportion of participants with high scores on both the S and D scales (SD group) was notably higher in the high NRS group. Logistic regression analysis showed that the SD group had a higher odds ratio (OR = 8.469, p = 0.004) for severe chronic pain, suggesting that SD traits independently contribute to worse pain. In the SD group, the self-denial scale scores were high, and self-denial traits showed a negative correlation with maternal attachment experiences in childhood. This finding indicates that poor maternal attachment may enhance self-denial traits, which in turn indirectly worsen pain through their effects on S and D traits. The results of this study highlight the importance of S and D traits as psychological factors in chronic pain, particularly in Japanese populations, and suggest that assessing self-suppressing behavioral patterns may be beneficial for pain management. However, the cross-cultural validity of the SAT scales requires further investigation. SAT therapy may provide a comprehensive approach to the treatment and prevention of complex conditions influenced by psychological and social factors, including chronic pain.

DOI PubMed
献体脳におけるアルツハイマー病理と認知機能に関する研究

中野正子, 小林英司, 永石歓和, 久原真, 藤宮峯子

臨床神経学 ( (一社)日本神経学会 ) 64 ( 6 ) 431 - 431 2024.06
Standardization of robot-assisted pelvic lymph node dissection-Development of a common understanding of regional anatomy and surgical technique based on cross-disciplinary discussion among colorectal surgery, urology, and gynecology.

Ichiro Takemasa, Atsushi Hamabe, Atsushi Takenaka, Hiroaki Kobayashi, Masaki Mandai, Yusuke Kinugasa, Takashi Saika, Masaki Shimbo, Shuichi Morizane, Kentaro Sekiyama, Shinichi Togami, Marie Hanaoka, Sena Inoue, Kanna Nagaishi, Yoshiharu Sakai, Masahiko Watanabe

Asian journal of endoscopic surgery 17 ( 1 ) e13274 2024.01 [Domestic journal]

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BACKGROUND: Pelvic lymph node dissection is a procedure performed in gastroenterological surgery, urology, and gynecology. However, due to discrepancies in the understanding of pelvic anatomy among these departments, cross-disciplinary discussions have not been easy. Recently, with the rapid spread of robotic surgery, the importance of visual information in understanding pelvic anatomy has become even more significant. In this project, we attempted to clarify a shared understanding of pelvic anatomy through cross-disciplinary discussions. METHOD: From May 2020 to November 2021, a total of 11 discussions were held entirely online with 5 colorectal surgery specialists, 4 urologists, and 4 gynecologists. The discussions focused on evidence from each specialty and surgical videos, aiming to create a universally understandable pelvic anatomical illustration. RESULTS: The common area of dissection recognized across the three departments was identified as the obturator lymph nodes. A dynamic illustration of pelvic anatomy was created. In addition to a bird's-eye view of the pelvis, a pelvic half view was developed to enhance understanding of the deeper pelvic anatomy. The following insights were incorporated into the illustration: (1) the cardinal ligament in gynecology partly overlaps with the vesicohypogastric fascia in colorectal surgery; (2) the obturator lymph nodes continue cephalad into the fossa of Marcille in urology; and (3) the deep uterine vein in gynecology corresponds to the inferior vesical vein in colorectal surgery. CONCLUSION: Based on the dynamic illustration of pelvic anatomy from cross-disciplinary discussions, we anticipate advancements in pelvic lymph node dissection aiming for curative and safe outcomes.

DOI PubMed
Dilemma of physician-mothers faced with an increased home burden and clinical duties in the hospital during the COVID-19 pandemic.

Sachiyo Nishida, Kanna Nagaishi, Masayo Motoya, Ayako Kumagai, Noriko Terada, Ai Kasuga, Narumi Kubota, Kotoe Iesato, Motonobu Kimizuka, Satsuki Miyajima, Masayuki Koyama, Hirofumi Ohnishi, Eichi Narimatsu, Naoya Masumori, Kazufumi Tsuchihashi, Taiji Tsukamoto, Yoshihisa Tsuji

PloS one 16 ( 6 ) e0253646 2021 [International journal]

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PURPOSE: Since December 2019, coronavirus disease 2019 (COVID-19) has spread rapidly across the world. During the pandemic, physicians in our hospital have had to respond both to the issue of treating the patients and the increasing domestic burden associated with social disruption. The purpose of this study was to assess how much the burden on our doctors, especially female doctors, was increasing. MATERIAL AND METHODS: The Physicians' Career Support Committee in Sapporo Medical University conducted a questionnaire survey. The questionnaire inquired about a wide range of subjects with regard to working style and family life during the first and second waves of the COVID-19 pandemic, and was sent to all medical/dental physicians working in Sapporo Medical University. RESULTS: A total of 266 (42.7%) physicians in our hospital responded to our questionnaire and the data for 264 data were analyzed. The total numbers of males, females, and others, including those who did not want to specify, were 178 (67.4%), 82 (31.0%), and 4 (1.5%), respectively. Among them, 62 (23.5%) and 23 (8.7%) answered that their domestic burden was slightly or markedly increased. The increase in the domestic burden showed a significant difference between genders (p = 0.04). Even after correction for background differences using multivariate analysis, being female (p<0.001), having child dependents (p<0.001), and treating COVID-19 patients (p = 0.03) were significantly related to an increased domestic burden. Regarding family style, 58.1% of the physician-fathers were from two-income families (i.e., families with both parents in employment), and they answered that their partner mainly cared for the children. In contrast, 97.3% of physician-mothers were from two-income families, and 94.6% of the physician-mothers had to take care of children by themselves. CONCLUSION: Physician-mothers are caught in a dilemma between an increased home burden and clinical duties in the hospital, with a significantly higher ratio than physician-fathers during the pandemic. As we showed, female doctors could have not continued their careers and take responsible positions in the same way as male doctors. This is a social risk in the timing of a crisis, such as a pandemic.

DOI PubMed

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難治性腸炎に対する間葉系幹細胞を用いた細胞療法—Mesenchymal stem cell therapy for intractable inflammatory bowel disease—研究者の最新動向

永石歓和, 仲瀬裕志

Precision medicine = プレシジョンメディシン / 「Precision medicine」編集委員会編 ( 東京 : 北隆館 ) 7 ( 7 ) 593 - 597 2024.06
献体脳におけるアルツハイマー病理と認知機能に関する研究

中野正子, 小林英司, 永石歓和, 久原真, 藤宮峯子

臨床神経学 ( (一社)日本神経学会 ) 64 ( 6 ) 431 - 431 2024.06
Mesenchymal stem cellsを知る—特集最新医療に向け新薬の標的を知る

永石歓和, 仲瀬裕志

消化器病学サイエンス = Science of gastroenterology / 「消化器病学サイエンス」編集委員会編 ( 東京 : 先端医学社 ) 7 ( 1 ) 33 - 38 2023.03
間葉系幹細胞を用いた炎症性疾患の細胞治療—Cell therapy for inflammatory disease using mesenchymal stem cells

永石歓和

Bio clinica = バイオクリニカ ( 東京 : 北隆館 ) 37 ( 12 ) 1155 - 1158 2022.11
細胞ファイバ技術によりスフェロイド化した間葉系幹細胞の特性と炎症抑制効果の検討

永石歓和, 池田和弘

北海道外科雑誌 ( 北海道外科学会 ) 67 ( 1 ) 93 - 94 2022.06