研究者詳細 - 永石　歓和

写真a

ナガイシ　カンナ

永石　歓和

所属

医学部解剖学講座機能構造学分野教授

ホームページ

https://kaken.nii.ac.jp/d/r/30544118.ja.html

外部リンク

研究キーワード

消化管運動
ストレス科学
骨髄ニッチ環境
糖尿病性腎症
間葉系幹細胞
炎症性腸疾患
解剖学
骨粗鬆症
糖尿病性肝障害
骨髄ニッチ
脳・骨髄相関
糖尿病

研究分野

ライフサイエンス / 細胞生物学
ライフサイエンス / 解剖学
ライフサイエンス / 消化器内科学

経歴

札幌医科大学医学部解剖学第二講座教授

2023年6月 - 現在

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札幌医科大学医学部准教授

2018年 - 2023年

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札幌医科大学医学部講師

2012年 - 2018年

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札幌医科大学医学部助教

2009年 - 2012年

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論文

Ultrasound-assisted middle thoracic epidural catheter placement utilizing the most dorsal sites of bilateral transverse process roots as anatomical landmarks: A cadaveric observational study and a clinical randomized controlled trial. 国際誌

Tatsuya Kunigo, Yusuke Yoshikawa, Shunichi Niki, Masahiro Ohtani, Mami Muraki, Asako Nitta, Yuki Ohsaki, Kanna Nagaishi, Michiaki Yamakage

Journal of clinical anesthesia 101 111740 - 111740 2025年1月

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記述言語：英語掲載種別：研究論文（学術雑誌）

STUDY OBJECTIVE: We developed an innovative method for ultrasound-assisted thoracic epidural catheter placement and assessed its potential to reduce procedural duration for trainees. DESIGN: A cadaveric observational study and a clinical randomized controlled trial. SETTING: Sapporo Medical University Hospital. PATIENTS: A total of 52 adult patients scheduled for thoracic or abdominal surgery and four cadavers. INTERVENTIONS: Patients were randomly assigned to either group receiving conventional palpation (conventional group) or combination of the ultrasound examination and conventional palpation (ultrasound group). MEASUREMENTS: The primary outcome was total procedure time (sum of skin marking time and needling time) by trainees. The secondary outcomes were (1) skin marking time, (2) needling time, (3) multiple skin punctures, (4) needle redirection, (5) complications, and (6) failed cases. MAIN RESULTS: Through dissection of four cadavers, the most dorsal site of the transverse process root was identifiable by ultrasound and the reliable indicator of the interlaminar space. We devised ultrasound-assisted middle thoracic epidural catheter placement utilizing the most dorsal sites of bilateral transverse process roots as anatomical landmarks. Trainees in the ultrasound group had significantly longer skin marking time and significantly shorter needling time than those in the conventional group (107 [87-158] vs 46 s [34-54] s, p < 0.001 and 197 [156-328] vs 341 [303-488] s, p = 0.003). Consequently, there was no significant difference between the two groups in total procedure time (326 [263-467] s vs 391 [354-533] s, p = 0.167). Moreover, the probability of trainee failure in epidural anesthesia was significantly lower in the ultrasound group (2/26 [17.7 %] vs 10/26 [38.5 %], p = 0.019). CONCLUSIONS: Our novel technique for thoracic epidural catheter placement resulted in expedited needling and enhanced success rates among trainees, although there was no significant difference between total procedure time when using ultrasound guidance and that when using conventional palpation.

DOI： 10.1016/j.jclinane.2024.111740

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Self-suppressing behavioral patterns and depressive traits exacerbate chronic pain: Psychological trait assessment using the structured association technique method. 国際誌

Shin Hashizume, Masako Nakano, Chihiro Ikehata, Nobuaki Himuro, Kanna Nagaishi, Mineko Fujimiya

PloS one 20 ( 3 ) e0319647 2025年

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記述言語：英語掲載種別：研究論文（学術雑誌）

This study investigated the relationship between psychological traits and chronic pain using the Structured Association Technique (SAT) method to evaluate psychological factors associated with chronic pain. The participants included 105 older adults (23 men, 82 women, mean age 80.82 years) who received rehabilitation services. Chronic pain severity was assessed using a numerical rating scale (NRS), and psychological traits were evaluated by SAT. In addition, maternal attachment experiences in childhood were examined. The NRS showed significant positive correlations with the self-suppressing behavioral pattern (S) scale (r = 0.31, p = 0.001), and the depression (D) scale (r = 0.31, p = 0.001). The proportion of participants with high scores on both the S and D scales (SD group) was notably higher in the high NRS group. Logistic regression analysis showed that the SD group had a higher odds ratio (OR = 8.469, p = 0.004) for severe chronic pain, suggesting that SD traits independently contribute to worse pain. In the SD group, the self-denial scale scores were high, and self-denial traits showed a negative correlation with maternal attachment experiences in childhood. This finding indicates that poor maternal attachment may enhance self-denial traits, which in turn indirectly worsen pain through their effects on S and D traits. The results of this study highlight the importance of S and D traits as psychological factors in chronic pain, particularly in Japanese populations, and suggest that assessing self-suppressing behavioral patterns may be beneficial for pain management. However, the cross-cultural validity of the SAT scales requires further investigation. SAT therapy may provide a comprehensive approach to the treatment and prevention of complex conditions influenced by psychological and social factors, including chronic pain.

DOI： 10.1371/journal.pone.0319647

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献体脳におけるアルツハイマー病理と認知機能に関する研究

中野正子, 小林英司, 永石歓和, 久原真, 藤宮峯子

臨床神経学 64 ( 6 ) 431 - 431 2024年6月

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記述言語：日本語出版者・発行元：(一社)日本神経学会

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Standardization of robot-assisted pelvic lymph node dissection-Development of a common understanding of regional anatomy and surgical technique based on cross-disciplinary discussion among colorectal surgery, urology, and gynecology.

Ichiro Takemasa, Atsushi Hamabe, Atsushi Takenaka, Hiroaki Kobayashi, Masaki Mandai, Yusuke Kinugasa, Takashi Saika, Masaki Shimbo, Shuichi Morizane, Kentaro Sekiyama, Shinichi Togami, Marie Hanaoka, Sena Inoue, Kanna Nagaishi, Yoshiharu Sakai, Masahiko Watanabe

Asian journal of endoscopic surgery 17 ( 1 ) e13274 2024年1月

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記述言語：英語掲載種別：研究論文（学術雑誌）

BACKGROUND: Pelvic lymph node dissection is a procedure performed in gastroenterological surgery, urology, and gynecology. However, due to discrepancies in the understanding of pelvic anatomy among these departments, cross-disciplinary discussions have not been easy. Recently, with the rapid spread of robotic surgery, the importance of visual information in understanding pelvic anatomy has become even more significant. In this project, we attempted to clarify a shared understanding of pelvic anatomy through cross-disciplinary discussions. METHOD: From May 2020 to November 2021, a total of 11 discussions were held entirely online with 5 colorectal surgery specialists, 4 urologists, and 4 gynecologists. The discussions focused on evidence from each specialty and surgical videos, aiming to create a universally understandable pelvic anatomical illustration. RESULTS: The common area of dissection recognized across the three departments was identified as the obturator lymph nodes. A dynamic illustration of pelvic anatomy was created. In addition to a bird's-eye view of the pelvis, a pelvic half view was developed to enhance understanding of the deeper pelvic anatomy. The following insights were incorporated into the illustration: (1) the cardinal ligament in gynecology partly overlaps with the vesicohypogastric fascia in colorectal surgery; (2) the obturator lymph nodes continue cephalad into the fossa of Marcille in urology; and (3) the deep uterine vein in gynecology corresponds to the inferior vesical vein in colorectal surgery. CONCLUSION: Based on the dynamic illustration of pelvic anatomy from cross-disciplinary discussions, we anticipate advancements in pelvic lymph node dissection aiming for curative and safe outcomes.

DOI： 10.1111/ases.13274

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Dilemma of physician-mothers faced with an increased home burden and clinical duties in the hospital during the COVID-19 pandemic. 国際誌

Sachiyo Nishida, Kanna Nagaishi, Masayo Motoya, Ayako Kumagai, Noriko Terada, Ai Kasuga, Narumi Kubota, Kotoe Iesato, Motonobu Kimizuka, Satsuki Miyajima, Masayuki Koyama, Hirofumi Ohnishi, Eichi Narimatsu, Naoya Masumori, Kazufumi Tsuchihashi, Taiji Tsukamoto, Yoshihisa Tsuji

PloS one 16 ( 6 ) e0253646 2021年

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記述言語：英語掲載種別：研究論文（学術雑誌）

PURPOSE: Since December 2019, coronavirus disease 2019 (COVID-19) has spread rapidly across the world. During the pandemic, physicians in our hospital have had to respond both to the issue of treating the patients and the increasing domestic burden associated with social disruption. The purpose of this study was to assess how much the burden on our doctors, especially female doctors, was increasing. MATERIAL AND METHODS: The Physicians' Career Support Committee in Sapporo Medical University conducted a questionnaire survey. The questionnaire inquired about a wide range of subjects with regard to working style and family life during the first and second waves of the COVID-19 pandemic, and was sent to all medical/dental physicians working in Sapporo Medical University. RESULTS: A total of 266 (42.7%) physicians in our hospital responded to our questionnaire and the data for 264 data were analyzed. The total numbers of males, females, and others, including those who did not want to specify, were 178 (67.4%), 82 (31.0%), and 4 (1.5%), respectively. Among them, 62 (23.5%) and 23 (8.7%) answered that their domestic burden was slightly or markedly increased. The increase in the domestic burden showed a significant difference between genders (p = 0.04). Even after correction for background differences using multivariate analysis, being female (p<0.001), having child dependents (p<0.001), and treating COVID-19 patients (p = 0.03) were significantly related to an increased domestic burden. Regarding family style, 58.1% of the physician-fathers were from two-income families (i.e., families with both parents in employment), and they answered that their partner mainly cared for the children. In contrast, 97.3% of physician-mothers were from two-income families, and 94.6% of the physician-mothers had to take care of children by themselves. CONCLUSION: Physician-mothers are caught in a dilemma between an increased home burden and clinical duties in the hospital, with a significantly higher ratio than physician-fathers during the pandemic. As we showed, female doctors could have not continued their careers and take responsible positions in the same way as male doctors. This is a social risk in the timing of a crisis, such as a pandemic.

DOI： 10.1371/journal.pone.0253646

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Author Correction: Umbilical cord extracts improve osteoporotic abnormalities of bone marrow-derived mesenchymal stem cells and promote their therapeutic effects on ovariectomised rats. 国際誌

Akira Saito, Kanna Nagaishi, Kousuke Iba, Yuka Mizue, Takako Chikenji, Miho Otani, Masako Nakano, Kazusa Oyama, Toshihiko Yamashita, Mineko Fujimiya

Scientific reports 10 ( 1 ) 21987 - 21987 2020年12月

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記述言語：英語掲載種別：研究論文（学術雑誌）出版者・発行元：Nature Research

DOI： 10.1038/s41598-020-78836-8

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Down-regulation of RalGTPase-Activating Protein Promotes Colitis-Associated Cancer via NLRP3 Inflammasome Activation. 査読国際誌

Tomoya Iida, Daisuke Hirayama, Naoki Minami, Minoru Matsuura, Kohei Wagatsuma, Kentaro Kawakami, Kanna Nagaishi, Masanori Nojima, Hiroki Ikeuchi, Seiichi Hirota, Ryutaro Shirakawa, Hisanori Horiuchi, Hiroshi Nakase

Cellular and molecular gastroenterology and hepatology 9 ( 2 ) 277 - 293 2020年

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記述言語：英語掲載種別：研究論文（学術雑誌）出版者・発行元：Elsevier BV

BACKGROUND & AIMS: Ral guanosine triphosphatase-activating protein α2 (RalGAPα2) is the major catalytic subunit of the negative regulators of the small guanosine triphosphatase Ral, a member of the Ras subfamily. Ral regulates tumorigenesis and invasion/metastasis of some cancers; however, the role of Ral in colitis-associated cancer (CAC) has not been investigated. We aimed to elucidate the role of Ral in the mechanism of CAC. METHODS: We used wild-type (WT) mice and RalGAPα2 knockout (KO) mice that showed Ral activation, and bone marrow chimeric mice were generated as follows: WT to WT, WT to RalGAPα2 KO, RalGAPα2 KO to WT, and RalGAPα2 KO to RalGAPα2 KO mice. CAC was induced in these mice by intraperitoneal injection of azoxymethane followed by dextran sulfate sodium intake. Intestinal epithelial cells were isolated from colon tissues, and we performed complementary DNA microarray analysis. Cytokine expression in normal colon tissues and CAC was analyzed by quantitative polymerase chain reaction. RESULTS: Bone marrow chimeric mice showed that immune cell function between WT mice and RalGAPα2 KO mice was not significantly different in the CAC mechanism. RalGAPα2 KO mice had a significantly larger tumor number and size and a significantly higher proportion of tumors invading the submucosa than WT mice. Higher expression levels of matrix metalloproteinase-9 and matrix metalloproteinase-13 were observed in RalGAPα2 KO mice than in WT mice. The expression levels of interleukin 1β, NLRP3, apoptosis associated speck-like protein containing a CARD, and caspase-1 were apparently increased in the tumors of RalGAPα2 KO mice compared with WT mice. NLRP3 inhibitor reduced the number of invasive tumors. CONCLUSIONS: Ral activation participates in the mechanism of CAC development via NLRP3 inflammasome activation.

DOI： 10.1016/j.jcmgh.2019.10.003

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Mitochondria transfer from mesenchymal stem cells structurally and functionally repairs renal proximal tubular epithelial cells in diabetic nephropathy in vivo. 査読国際誌

Naoto Konari, Kanna Nagaishi, Shin Kikuchi, Mineko Fujimiya

Scientific reports 9 ( 1 ) 5184 - 5184 2019年3月

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記述言語：英語掲載種別：研究論文（学術雑誌）

The underlying therapeutic mechanism of renal tubular epithelium repair of diabetic nephropathy (DN) by bone marrow-derived mesenchymal stem cells (BM-MSCs) has not been fully elucidated. Recently, mitochondria (Mt) transfer was reported as a novel action of BM-MSCs to rescue injured cells. We investigated Mt transfer from systemically administered BM-MSCs to renal proximal tubular epithelial cells (PTECs) in streptozotocin (STZ)-induced diabetic animals. BM-MSCs also transferred their Mt to impaired PTECs when co-cultured in vitro, which suppressed apoptosis of impaired PTECs. Additionally, BM-MSC-derived isolated Mt enhanced the expression of mitochondrial superoxide dismutase 2 and Bcl-2 expression and inhibited reactive oxygen species (ROS) production in vitro. Isolated Mt also inhibited nuclear translocation of PGC-1α and restored the expression of megalin and SGLT2 under high glucose condition (HG) in PTECs. Moreover, isolated Mt directly injected under the renal capsule of STZ rats improved the cellular morphology of STZ-PTECs, and the structure of the tubular basement membrane and brush border in vivo. This study is the first to show Mt transfer from systemically administered BM-MSCs to damaged PTECs in vivo, and the first to investigate mechanisms underlying the potential therapeutic effects of Mt transfer from BM-MSCs in DN.

DOI： 10.1038/s41598-019-40163-y

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Activated forms of astrocytes with higher GLT-1 expression are associated with cognitive normal subjects with Alzheimer pathology in human brain. 査読国際誌

Eiji Kobayashi, Masako Nakano, Kenta Kubota, Nobuaki Himuro, Shougo Mizoguchi, Takako Chikenji, Miho Otani, Yuka Mizue, Kanna Nagaishi, Mineko Fujimiya

Scientific reports 8 ( 1 ) 1712 - 1712 2018年1月

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記述言語：英語掲載種別：研究論文（学術雑誌）

Although the cognitive impairment in Alzheimer's disease (AD) is believed to be caused by amyloid-β (Aβ) plaques and neurofibrillary tangles (NFTs), several postmortem studies have reported cognitive normal subjects with AD brain pathology. As the mechanism underlying these discrepancies has not been clarified, we focused the neuroprotective role of astrocytes. After examining 47 donated brains, we classified brains into 3 groups, no AD pathology with no dementia (N-N), AD pathology with no dementia (AD-N), and AD pathology with dementia (AD-D), which represented 41%, 21%, and 38% of brains, respectively. No differences were found in the accumulation of Aβ plaques or NFTs in the entorhinal cortex (EC) between AD-N and AD-D. Number of neurons and synaptic density were increased in AD-N compared to those in AD-D. The astrocytes in AD-N possessed longer or thicker processes, while those in AD-D possessed shorter or thinner processes in layer I/II of the EC. Astrocytes in all layers of the EC in AD-N showed enhanced GLT-1 expression in comparison to those in AD-D. Therefore these activated forms of astrocytes with increased GLT-1 expression may exert beneficial roles in preserving cognitive function, even in the presence of Aβ and NFTs.

DOI： 10.1038/s41598-018-19442-7

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Umbilical cord extracts improve osteoporotic abnormalities of bone marrow-derived mesenchymal stem cells and promote their therapeutic effects on ovariectomised rats. 査読国際誌

Akira Saito, Kanna Nagaishi, Kousuke Iba, Yuka Mizue, Takako Chikenji, Miho Otani, Masako Nakano, Kazusa Oyama, Toshihiko Yamashita, Mineko Fujimiya

Scientific reports 8 ( 1 ) 1161 - 1161 2018年1月

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記述言語：英語掲載種別：研究論文（学術雑誌）出版者・発行元：Nature Publishing Group

DOI： 10.1038/s41598-018-19516-6

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An enriched environment prevents diabetes-induced cognitive impairment in rats by enhancing exosomal miR-146a secretion from endogenous bone marrow-derived mesenchymal stem cells. 査読国際誌

Kenta Kubota, Masako Nakano, Eiji Kobayashi, Yuka Mizue, Takako Chikenji, Miho Otani, Kanna Nagaishi, Mineko Fujimiya

PloS one 13 ( 9 ) e0204252 2018年

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記述言語：英語掲載種別：研究論文（学術雑誌）

Increasing evidence suggests that an enriched environment (EE) ameliorates cognitive impairment by promoting repair of brain damage. However, the mechanisms by which this occurs have not been determined. To address this issue, we investigated whether an EE enhanced the capability of endogenous bone marrow-derived mesenchymal stem/stromal cells (BM-MSCs) to prevent hippocampal damage due to diabetes by focusing on miRNA carried in BM-MSC-derived exosomes. In diabetic streptozotocin (STZ) rats housed in an EE (STZ/EE), cognitive impairment was significantly reduced, and both neuronal and astroglial damage in the hippocampus was alleviated compared with STZ rats housed in conventional cages (STZ/CC). BM-MSCs isolated from STZ/CC rats had functional and morphological abnormalities that were not detected in STZ/EE BM-MSCs. The miR-146a levels in exosomes in conditioned medium of cultured BM-MSCs and serum from STZ/CC rats were decreased compared with non-diabetic rats, and the level was restored in STZ/EE rats. Thus, the data suggest that increased levels of miR-146a in sera were derived from endogenous BM-MSCs in STZ/EE rats. To examine the possibility that increased miR-146a in serum may exert anti-inflammatory effects on astrocytes in diabetic rats, astrocytes transfected with miR-146a were stimulated with advanced glycation end products (AGEs) to mimic diabetic conditions. The expression of IRAK1, NF-κB, and tumor necrosis factor-α was significantly higher in AGE-stimulated astrocytes, and these factors were decreased in miR-146a-transfected astrocytes. These results suggested that EEs stimulate up-regulation of exosomal miR-146a secretion by endogenous BM-MSCs, which exerts anti-inflammatory effects on damaged astrocytes and prevents diabetes-induced cognitive impairment.

DOI： 10.1371/journal.pone.0204252

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Umbilical cord extracts improve diabetic abnormalities in bone marrow-derived mesenchymal stem cells and increase their therapeutic effects on diabetic nephropathy. 査読国際誌

Kanna Nagaishi, Yuka Mizue, Takako Chikenji, Miho Otani, Masako Nakano, Yusaku Saijo, Hikaru Tsuchida, Shinichi Ishioka, Akira Nishikawa, Tsuyoshi Saito, Mineko Fujimiya

Scientific reports 7 ( 1 ) 8484 - 8484 2017年8月

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記述言語：英語掲載種別：研究論文（学術雑誌）

DOI： 10.1038/s41598-017-08921-y

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Establishment of a refined culture method for rat colon organoids. 査読国際誌

Hiroyuki Isshiki, Yoshiaki Arimura, Kanna Nagaishi, Kentaro Kawakami, Kei Onodera, Kentaro Yamashita, Yasuyoshi Naishiro, Mineko Fujimiya, Kohzoh Imai, Yasuhisa Shinomura

Biochemical and biophysical research communications 489 ( 3 ) 305 - 311 2017年7月

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記述言語：英語掲載種別：研究論文（学術雑誌）

DOI： 10.1016/j.bbrc.2017.05.142

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Osteopontin attenuates acute gastrointestinal graft-versus-host disease by preventing apoptosis of intestinal epithelial cells. 査読国際誌

Kentaro Kawakami, Naoki Minami, Minoru Matsuura, Tomoya Iida, Takahiko Toyonaga, Kanna Nagaishi, Yoshiaki Arimura, Mineko Fujimiya, Toshimitsu Uede, Hiroshi Nakase

Biochemical and biophysical research communications 485 ( 2 ) 468 - 475 2017年4月

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記述言語：英語掲載種別：研究論文（学術雑誌）

DOI： 10.1016/j.bbrc.2017.02.047

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Mesenchymal stem cell therapy ameliorates diabetic nephropathy via the paracrine effect of renal trophic factors including exosomes. 査読国際誌

Kanna Nagaishi, Yuka Mizue, Takako Chikenji, Miho Otani, Masako Nakano, Naoto Konari, Mineko Fujimiya

Scientific reports 6 34842 - 34842 2016年10月

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記述言語：英語掲載種別：研究論文（学術雑誌）

DOI： 10.1038/srep34842

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胎児付属物抽出液で賦活化した骨髄間葉系幹細胞による糖尿病性腎症の新規治療法の開発

永石歓和, 水江由佳, 千見寺貴子, 中野正子, 小成直人, 藤宮峯子, 大谷美穂

北海道外科雑誌 61 ( 1 ) 126 - 127 2016年6月

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記述言語：日本語出版者・発行元：北海道外科学会

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Bone marrow-derived mesenchymal stem cells improve diabetes-induced cognitive impairment by exosome transfer into damaged neurons and astrocytes. 査読国際誌

Masako Nakano, Kanna Nagaishi, Naoto Konari, Yuki Saito, Takako Chikenji, Yuka Mizue, Mineko Fujimiya

Scientific reports 6 ( 1 ) 24805 - 24805 2016年4月

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記述言語：英語掲載種別：研究論文（学術雑誌）出版者・発行元：Springer Science and Business Media {LLC}

The incidence of dementia is higher in diabetic patients, but no effective treatment has been developed. This study showed that rat bone marrow mesenchymal stem cells (BM-MSCs) can improve the cognitive impairments of STZ-diabetic mice by repairing damaged neurons and astrocytes. The Morris water maze test demonstrated that cognitive impairments induced by diabetes were significantly improved by intravenous injection of BM-MSCs. In the CA1 region of the hippocampus, degeneration of neurons and astrocytes, as well as synaptic loss, were prominent in diabetes, and BM-MSC treatment successfully normalized them. Since a limited number of donor BM-MSCs was observed in the brain parenchyma, we hypothesized that humoral factors, especially exosomes released from BM-MSCs, act on damaged neurons and astrocytes. To investigate the effectiveness of exosomes for treatment of diabetes-induced cognitive impairment, exosomes were purified from the culture media and injected intracerebroventricularly into diabetic mice. Recovery of cognitive impairment and histological abnormalities similar to that seen with BM-MSC injection was found following exosome treatment. Use of fluorescence-labeled exosomes demonstrated that injected exosomes were internalized into astrocytes and neurons; these subsequently reversed the dysfunction. The present results indicate that exosomes derived from BM-MSCs might be a promising therapeutic tool for diabetes-induced cognitive impairment.

DOI： 10.1038/srep24805

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Low-Frequency IL23R Coding Variant Associated with Crohn's Disease Susceptibility in Japanese Subjects Identified by Personal Genomics Analysis. 査読国際誌

Kei Onodera, Yoshiaki Arimura, Hiroyuki Isshiki, Kentaro Kawakami, Kanna Nagaishi, Kentaro Yamashita, Eiichiro Yamamoto, Takeshi Niinuma, Yasuyoshi Naishiro, Hiromu Suzuki, Kohzoh Imai, Yasuhisa Shinomura

PloS one 10 ( 9 ) e0137801 2015年9月

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記述言語：英語掲載種別：研究論文（学術雑誌）

DOI： 10.1371/journal.pone.0137801

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Contextual niche signals towards colorectal tumor progression by mesenchymal stem cell in the mouse xenograft model. 査読

Suguru Nakagaki, Yoshiaki Arimura, Kanna Nagaishi, Hiroyuki Isshiki, Masanao Nasuno, Shuhei Watanabe, Masashi Idogawa, Kentaro Yamashita, Yasuyoshi Naishiro, Yasushi Adachi, Hiromu Suzuki, Mineko Fujimiya, Kohzoh Imai, Yasuhisa Shinomura

Journal of gastroenterology 50 ( 9 ) 962 - 74 2015年9月

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記述言語：英語掲載種別：研究論文（学術雑誌）

DOI： 10.1007/s00535-015-1049-0

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Stem cell therapy for inflammatory bowel disease. 査読

Kanna Nagaishi, Yoshiaki Arimura, Mineko Fujimiya

Journal of gastroenterology 50 ( 3 ) 280 - 6 2015年3月

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記述言語：英語掲載種別：研究論文（学術雑誌）

DOI： 10.1007/s00535-015-1040-9

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Suppression of bone marrow-derived microglia in the amygdala improves anxiety-like behavior induced by chronic partial sciatic nerve ligation in mice. 査読国際誌

Atsushi Sawada, Yukitoshi Niiyama, Koji Ataka, Kanna Nagaishi, Michiaki Yamakage, Mineko Fujimiya

Pain 155 ( 9 ) 1762 - 1772 2014年9月

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記述言語：英語掲載種別：研究論文（学術雑誌）

DOI： 10.1016/j.pain.2014.05.031

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Characteristics of Japanese inflammatory bowel disease susceptibility loci. 査読

Yoshiaki Arimura, Hiroyuki Isshiki, Kei Onodera, Kanna Nagaishi, Kentaro Yamashita, Tomoko Sonoda, Takayuki Matsumoto, Atsushi Takahashi, Masakazu Takazoe, Keiko Yamazaki, Michiaki Kubo, Mineko Fujimiya, Kohzoh Imai, Yasuhisa Shinomura

Journal of gastroenterology 49 ( 8 ) 1217 - 30 2014年8月

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記述言語：英語掲載種別：研究論文（学術雑誌）

DOI： 10.1007/s00535-013-0866-2

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Mesenchymal stem cell therapy ameliorates diabetic hepatocyte damage in mice by inhibiting infiltration of bone marrow-derived cells. 査読国際誌

Kanna Nagaishi, Koji Ataka, Eijiro Echizen, Yoshiaki Arimura, Mineko Fujimiya

Hepatology (Baltimore, Md.) 59 ( 5 ) 1816 - 29 2014年5月

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記述言語：英語掲載種別：研究論文（学術雑誌）

DOI： 10.1002/hep.26975

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Mesenchymal stem cells cancel azoxymethane-induced tumor initiation. 査読国際誌

Masanao Nasuno, Yoshiaki Arimura, Kanna Nagaishi, Hiroyuki Isshiki, Kei Onodera, Suguru Nakagaki, Shuhei Watanabe, Masashi Idogawa, Kentaro Yamashita, Yasuyoshi Naishiro, Yasushi Adachi, Hiromu Suzuki, Mineko Fujimiya, Kohzoh Imai, Yasuhisa Shinomura

Stem cells (Dayton, Ohio) 32 ( 4 ) 913 - 25 2014年4月

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記述言語：英語掲載種別：研究論文（学術雑誌）

DOI： 10.1002/stem.1594

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Conditioned mesenchymal stem cells produce pleiotropic gut trophic factors. 査読

Shuhei Watanabe, Yoshiaki Arimura, Kanna Nagaishi, Hiroyuki Isshiki, Kei Onodera, Masanao Nasuno, Kentaro Yamashita, Masashi Idogawa, Yasuyoshi Naishiro, Masaki Murata, Yasushi Adachi, Mineko Fujimiya, Kohzoh Imai, Yasuhisa Shinomura

Journal of gastroenterology 49 ( 2 ) 270 - 82 2014年2月

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記述言語：英語掲載種別：研究論文（学術雑誌）

DOI： 10.1007/s00535-013-0901-3

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Bone marrow-derived microglia infiltrate into the paraventricular nucleus of chronic psychological stress-loaded mice. 査読国際誌

Koji Ataka, Akihiro Asakawa, Kanna Nagaishi, Kaori Kaimoto, Atsushi Sawada, Yuko Hayakawa, Ryota Tatezawa, Akio Inui, Mineko Fujimiya

PloS one 8 ( 11 ) e81744 2013年11月

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記述言語：英語掲載種別：研究論文（学術雑誌）

DOI： 10.1371/journal.pone.0081744

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Diabetes impairs the interactions between long-term hematopoietic stem cells and osteopontin-positive cells in the endosteal niche of mouse bone marrow. 査読国際誌

Hironori Chiba, Koji Ataka, Kousuke Iba, Kanna Nagaishi, Toshihiko Yamashita, Mineko Fujimiya

American journal of physiology. Cell physiology 305 ( 7 ) C693-703 - C703 2013年10月

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記述言語：英語掲載種別：研究論文（学術雑誌）

DOI： 10.1152/ajpcell.00400.2012

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The immunologic functions of the neonatal Fc receptor for IgG. 国際誌

Timo Rath, Timothy T Kuo, Kristi Baker, Shuo-Wang Qiao, Kanna Kobayashi, Masaru Yoshida, Derry Roopenian, Edda Fiebiger, Wayne I Lencer, Richard S Blumberg

Journal of clinical immunology 33 Suppl 1 ( Suppl 1 ) S9-17 2013年1月

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記述言語：英語掲載種別：研究論文（学術雑誌）

Careful regulation of the body's immunoglobulin G (IgG) and albumin concentrations is necessitated by the importance of their respective functions. As such, the neonatal Fc receptor (FcRn), as a single receptor, is capable of regulating both of these molecules and has become an important focus of investigation. In addition to these essential protection functions, FcRn possesses a number of other functions that are equally as critical and are increasingly coming to attention. During the very first stages of life, FcRn mediates the passive transfer of IgG from mother to offspring both before and after birth. In the adult, FcRn regulates the persistence of both IgG and albumin in the serum as well as the movement of IgG, and any bound cargo, between different compartments of the body via transcytosis across polarized cells. FcRn is also expressed by hematopoietic cells; consistent with this, FcRn regulates MHC class II presentation and MHC class I cross-presentation by dendritic cells. As such, FcRn plays an important role in immune surveillance throughout adult life. The increasing appreciation for FcRn in both homeostatic and pathological conditions is generating an intense interest in the potential for therapeutic modulation of FcRn binding to IgG and albumin.

DOI： 10.1007/s10875-012-9768-y

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Alteration of antral and proximal colonic motility induced by chronic psychological stress involves central urocortin 3 and vasopressin in rats. 査読国際誌

Koji Ataka, Kanna Nagaishi, Akihiro Asakawa, Akio Inui, Mineko Fujimiya

American journal of physiology. Gastrointestinal and liver physiology 303 ( 4 ) G519-28 - G528 2012年8月

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記述言語：英語掲載種別：研究論文（学術雑誌）

DOI： 10.1152/ajpgi.00390.2011

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Bone marrow stem cell abnormality and diabetic complications. 査読国際誌

Mineko Fujimiya, Kanna Nagaishi, Tomohisa Yamashita, Koji Ataka

Anatomical record (Hoboken, N.J. : 2007) 295 ( 6 ) 917 - 21 2012年6月

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記述言語：英語掲載種別：研究論文（学術雑誌）

DOI： 10.1002/ar.22445

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Fusion of bone marrow-derived cells with renal tubules contributes to renal dysfunction in diabetic nephropathy. 査読国際誌

Tomohisa Yamashita, Mineko Fujimiya, Kanna Nagaishi, Koji Ataka, Marenao Tanaka, Hideaki Yoshida, Kazufumi Tsuchihashi, Kazuaki Shimamoto, Tetsuji Miura

FASEB journal : official publication of the Federation of American Societies for Experimental Biology 26 ( 4 ) 1559 - 68 2012年4月

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記述言語：英語掲載種別：研究論文（学術雑誌）

DOI： 10.1096/fj.11-183194

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Myogenic lineage differentiated mesenchymal stem cells enhance recovery from dextran sulfate sodium-induced colitis in the rat. 査読

Hiroki Tanaka, Yoshiaki Arimura, Takashi Yabana, Akira Goto, Masayo Hosokawa, Kanna Nagaishi, Kentaro Yamashita, Hiroyuki Yamamoto, Yasushi Sasaki, Mineko Fujimiya, Kohzoh Imai, Yasuhisa Shinomura

Journal of gastroenterology 46 ( 2 ) 143 - 52 2011年2月

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記述言語：英語掲載種別：研究論文（学術雑誌）

DOI： 10.1007/s00535-010-0320-7

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Dynamics of claudins expression in colitis and colitis-associated cancer in rat. 査読国際誌

Yoshiaki Arimura, Kanna Nagaishi, Masayo Hosokawa

Methods in molecular biology (Clifton, N.J.) 762 409 - 25 2011年

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記述言語：英語掲載種別：研究論文（学術雑誌）

Claudins comprise a multigene family of 24 species and have been shown to constitute the backbone of tight junction strands in simple epithelial cells and to be directly involved in their barrier functions. Apical-most tight junction protein complexes (TJs) are implicated in inflammatory bowel disease (IBD) pathophysiology. Except for claudin-8, TJs explored in this study (including ZO-1, claudin-1, -2, -3, -7, -12, and -15) were found to be expressed in rat colonic tissues. ZO-1 and claudin-7 were ubiquitously expressed in all study groups. As depicted in Fig. 1b, expressions of claudin-2, -12, and -15 significantly diminished after combined treatment with dextran sulfate sodium (DSS) and busulfan (BU) (lane 5), compared with either agent alone (lanes 2 and 4). Despite the lack of significance, there appeared to be a subtle dose-dependent decrease with DSS treatment (lanes 2 and 3). In contrast to these results obtained from DSS colitis, expression of claudin-1 was significantly downregulated, while expression of claudin-15 was upregulated in colitis-associated cancer tissues in the azoxymethane (AOM)/DSS model (Fig. 2b). It is very intriguing that claudins' expression dynamics were mutually exclusive between colitis and colitis-associated cancer in rats. However, the biological significance of disease-specific claudin expression profiles will remain elusive until the specific expression and function of each claudin in a tissue- and cell-type relationship are comprehensively clarified. Currently, the physiologic consequences of the diversity of TJ barrier function resulting from multiple combinations of claudins are only beginning to be recognized. Full unraveling of these complexities could inspire a new paradigm of inflammation and cancer, and eventually translate to clinical practice on IBD.

DOI： 10.1007/978-1-61779-185-7_29

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An FcRn-dependent role for anti-flagellin immunoglobulin G in pathogenesis of colitis in mice. 国際誌

Kanna Kobayashi, Shuo-Wang Qiao, Masaru Yoshida, Kristi Baker, Wayne I Lencer, Richard S Blumberg

Gastroenterology 137 ( 5 ) 1746 - 56 2009年11月

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記述言語：英語掲載種別：研究論文（学術雑誌）

BACKGROUND & AIMS: The neonatal Fc receptor for immunoglobulin (Ig)G (FcRn) protects monomeric IgG from catabolism in parenchymal and hematopoietic cells during adult life. In dendritic cells, FcRn also promotes presentation of antigens in association with IgG. Because IgGs with anti-bacterial specificity are a hallmark of inflammatory bowel disease, we sought to determine their significance and relationship to FcRn expression in antigen-presenting cells, focusing on IgGs specific for flagellin. METHODS: Levels of circulating anti-flagellin IgG were induced in wild-type and FcRn(-/-) mice, followed by induction of colitis with dextran sodium sulfate (DSS). Bone marrow chimera models were used to localize the site of FcRn action. RESULTS: Wild-type mice that received anti-flagellin IgG exhibited more severe colitis following administration of DSS, compared with mice that received control IgG. Wild-type mice immunized with flagellin exhibited significantly more severe colitis in response to DSS administration than that observed in similarly treated FcRn(-/-) mice. In chimera studies, FcRn(-/-) mice given wild-type bone marrow and immunized with flagellin exhibited significantly more colitis than wild-type mice given FcRn(-/-) bone marrow and immunized with flagellin. Serum anti-flagellin IgG levels were similar in both sets of chimeric mice, consistent with the equal participation of hematopoietic and nonhematopoeitic cells in FcRn-mediated IgG protection. CONCLUSIONS: Anti-bacterial IgG antibodies are involved in the pathogenesis of colitis; this pathway requires FcRn in antigen presenting cells, the major subset of hematopoietic cells that express FcRn.

DOI： 10.1053/j.gastro.2009.07.059

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Immune and non-immune functions of the (not so) neonatal Fc receptor, FcRn. 国際誌

Kristi Baker, Shuo-Wang Qiao, Timothy Kuo, Kanna Kobayashi, Masaru Yoshida, Wayne I Lencer, Richard S Blumberg

Seminars in immunopathology 31 ( 2 ) 223 - 36 2009年7月

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記述言語：英語掲載種別：研究論文（学術雑誌）

Careful regulation of the body's immunoglobulin-G (IgG) and albumin concentrations is necessitated by the importance of their respective functions. As such, the neonatal Fc receptor (FcRn) which, as a single receptor, is capable of regulating both of these molecules, has become an important focus of investigation. In addition to these essential protection functions, FcRn possesses a host of other functions that are equally as critical. During the very first stages of life, FcRn mediates the passive transfer of IgG from mother to offspring both before and after birth. In the adult, FcRn regulates the persistence of both IgG and albumin in the serum as well as the movement of IgG, and any bound cargo, between different compartments of the body. This shuttling allows for the movement not only of monomeric ligand but also of antigen/antibody complexes from one cell type to another in such a way as to facilitate the efficient initiation of immune responses towards opsonized pathogens. As such, FcRn continues to play the role of an immunological sensor throughout adult life, particularly in regions such as the gut which are exposed to a large number of infectious antigens. Increasing appreciation for the contributions of FcRn to both homeostatic and pathological states is generating an intense interest in the potential for therapeutic modulation of FcRn binding. A greater understanding of FcRn's pleiotropic roles is thus imperative for a variety of therapeutic purposes.

DOI： 10.1007/s00281-009-0160-9

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Enhancing epithelial engraftment of rat mesenchymal stem cells restores epithelial barrier integrity. 査読国際誌

Takashi Yabana, Yoshiaki Arimura, Hiroki Tanaka, Akira Goto, Masayo Hosokawa, Kanna Nagaishi, Kentaro Yamashita, Hiroyuki Yamamoto, Yasushi Adachi, Yasushi Sasaki, Masaharu Isobe, Mineko Fujimiya, Kohzoh Imai, Yasuhisa Shinomura

The Journal of pathology 218 ( 3 ) 350 - 9 2009年7月

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記述言語：英語掲載種別：研究論文（学術雑誌）

DOI： 10.1002/path.2535

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Genetic variants in surfactant, pulmonary-associated protein D (SFTPD) and Japanese susceptibility to ulcerative colitis. 査読国際誌

Michihiro Tanaka, Yoshiaki Arimura, Akira Goto, Masayo Hosokawa, Kanna Nagaishi, Kentaro Yamashita, Hiroyuki Yamamoto, Tomoko Sonoda, Masafumi Nomura, Satoshi Motoya, Kohzoh Imai, Yasuhisa Shinomura

Inflammatory bowel diseases 15 ( 6 ) 918 - 25 2009年6月

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記述言語：英語掲載種別：研究論文（学術雑誌）

DOI： 10.1002/ibd.20936

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{alpha}' Subunit of soybean {beta}-conglycinin forms complex with rice glutelin via a disulphide bond in transgenic rice seeds. 国際誌

Takayasu Motoyama, Nobuyuki Maruyama, Yoshiki Amari, Kanna Kobayashi, Haruhiko Washida, Takahiko Higasa, Fumio Takaiwa, Shigeru Utsumi

Journal of experimental botany 60 ( 14 ) 4015 - 27 2009年

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記述言語：英語掲載種別：研究論文（学術雑誌）

The alpha' and beta subunits of soybean beta-conglycinin were expressed in rice seeds in order to improve the nutritional and physiological properties of rice as a food. The alpha' subunit accumulated in rice seeds at a higher level than the beta subunit, but no detectable difference in mRNA transcription level between subunits was observed. Sequential extraction results indicate that the alpha' subunit formed one or more disulphide bonds with glutelin. Electron microscopic analysis showed that the alpha' subunit and the beta subunit were transported to PB-II together with glutelin. In mature transgenic seeds, the beta subunit accumulated in low electron density regions in the periphery of PB-II, whereas the alpha' subunit accumulated together with glutelin in high-density regions of the periphery. The subcellular localization of mutated alpha' subunits lacking one cysteine residue in the N-terminal mature region (alpha'DeltaCys1) or five cysteine residues in the pro and N-terminal mature regions (alpha'DeltaCys5) were also examined. Low-density regions were formed in PB-II in mature seeds of transgenic rice expressing alpha'DeltaCys 5 and alpha'DeltaCys1. alpha'DeltaCys5 was localized only in the low-density regions, whereas alpha'DeltaCys1 was found in both low- and high-density regions. These results suggest that the alpha' subunit could make a complex via one or more disulphide bonds with glutelin and accumulate together in PB-II of transgenic rice seeds.

DOI： 10.1093/jxb/erp235

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Dependence of antibody-mediated presentation of antigen on FcRn. 国際誌

Shuo-Wang Qiao, Kanna Kobayashi, Finn-Eirik Johansen, Ludvig M Sollid, Jan Terje Andersen, Edgar Milford, Derry C Roopenian, Wayne I Lencer, Richard S Blumberg

Proceedings of the National Academy of Sciences of the United States of America 105 ( 27 ) 9337 - 42 2008年7月

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記述言語：英語掲載種別：研究論文（学術雑誌）

The neonatal Fc receptor for IgG (FcRn) is a distant member of the MHC class I protein family. It binds IgG and albumin in a pH-dependent manner and protects these from catabolism by diverting them from a degradative fate in lysosomes. In addition, FcRn-mediated IgG transport across epithelial barriers is responsible for the transmission of IgG from mother to infant and can also enhance IgG-mediated antigen uptake across mucosal epithelia. We now show a previously undescribed role for FcRn in mediating the presentation of antigens by dendritic cells when antigens are present as a complex with antibody by uniquely directing multimeric immune complexes, but not monomeric IgG, to lysosomes.

DOI： 10.1073/pnas.0801717105

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Fcgamma receptor regulation of Citrobacter rodentium infection. 国際誌

Atsuhiro Masuda, Masaru Yoshida, Hideyuki Shiomi, Satoshi Ikezawa, Tetsuya Takagawa, Hiroshi Tanaka, Ryo Chinzei, Tsukasa Ishida, Yoshinori Morita, Hiromu Kutsumi, Hideto Inokuchi, Shuo Wang, Kanna Kobayashi, Shigeto Mizuno, Akira Nakamura, Toshiyuki Takai, Richard S Blumberg, Takeshi Azuma

Infection and immunity 76 ( 4 ) 1728 - 37 2008年4月

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記述言語：英語掲載種別：研究論文（学術雑誌）

Citrobacter rodentium, a murine model pathogen for enteropathogenic Escherichia coli, colonizes the colon utilizing attaching and effacing lesions to adhere specifically to the surfaces of intestinal epithelial cells and cause mucosal inflammation. CD4+ T cells, B cells, and immunoglobulin G (IgG), but not secretory IgA or IgM, play a critical role in eradicating this pathogen. Consistent with the importance of IgG in C. rodentium eradication, IgG transport by the neonatal Fc receptor for IgG within the intestinal epithelium also has a critical role in the regulation of C. rodentium infection. It remains to be determined, however, whether Fcgamma receptors (FcgammaRs), the receptors for the Fc portion of IgG, regulate this bacterial infection within mucosal tissues. Therefore, we investigated the roles of FcgammaRs during C. rodentium infection. Fc receptor common gamma chain (FcRgamma)-deficient mice were more susceptible to C. rodentium-induced colitis. This occurred through decreased efficiency of FcR-mediated endocytosis and maturation of dendritic cells and consequently T-cell activation of antigen-specific T cells. Moreover, in the absence of FcgammaRs, phagocytosis by macrophages was significantly diminished. Therefore, activating FcgammaRs play an important role in defending against C. rodentium infection, indicating that the critical role played by IgG in this infection is not mediated by IgG alone but is dependent upon this class of receptors.

DOI： 10.1128/IAI.01493-07

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IgG transport across mucosal barriers by neonatal Fc receptor for IgG and mucosal immunity. 国際誌

Masaru Yoshida, Atsuhiro Masuda, Timothy T Kuo, Kanna Kobayashi, Steven M Claypool, Tetsuya Takagawa, Hiromu Kutsumi, Takeshi Azuma, Wayne I Lencer, Richard S Blumberg

Springer seminars in immunopathology 28 ( 4 ) 397 - 403 2006年12月

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記述言語：英語掲載種別：研究論文（学術雑誌）

Mucosal secretions of the human gastrointestinal, respiratory, and genital tracts contain significant quantities of IgG. The neonatal Fc receptor for IgG (FcRn) plays a major role in regulating host IgG levels and transporting IgG and associated antigens across polarized epithelial barriers. The FcRn can then recycle the IgG/antigen complex back across the intestinal barrier into the lamina propria for processing by dendritic cells and presentation to CD4(+) T cells in regional organized lymphoid structures. FcRn, through its ability to secrete and absorb IgG, thus integrates luminal antigen encounters with systemic immune compartments and, as such, provides essential host defense and immunoregulatory functions at the mucosal surfaces.

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Neonatal Fc receptor for IgG regulates mucosal immune responses to luminal bacteria. 国際誌

Masaru Yoshida, Kanna Kobayashi, Timothy T Kuo, Lynn Bry, Jonathan N Glickman, Steven M Claypool, Arthur Kaser, Takashi Nagaishi, Darren E Higgins, Emiko Mizoguchi, Yoshio Wakatsuki, Derry C Roopenian, Atsushi Mizoguchi, Wayne I Lencer, Richard S Blumberg

The Journal of clinical investigation 116 ( 8 ) 2142 - 2151 2006年8月

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記述言語：英語掲載種別：研究論文（学術雑誌）

The neonatal Fc receptor for IgG (FcRn) plays a major role in regulating host IgG levels and transporting IgG and associated antigens across polarized epithelial barriers. Selective expression of FcRn in the epithelium is shown here to be associated with secretion of IgG into the lumen that allows for defense against an epithelium-associated pathogen (Citrobacter rodentium). This pathway of host resistance to a bacterial pathogen as mediated by FcRn involves retrieval of bacterial antigens from the lumen and initiation of adaptive immune responses in regional lymphoid structures. Epithelial-associated FcRn, through its ability to secrete and absorb IgG, may thus integrate luminal antigen encounters with systemic immune compartments and as such provide essential host defense and immunoregulatory functions at the mucosal surfaces.

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MISC

難治性腸炎に対する間葉系幹細胞を用いた細胞療法—Mesenchymal stem cell therapy for intractable inflammatory bowel disease—研究者の最新動向

永石歓和, 仲瀬裕志

Precision medicine = プレシジョンメディシン / 「Precision medicine」編集委員会編 7 ( 7 ) 593 - 597 2024年6月

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記述言語：日本語出版者・発行元：東京 : 北隆館

その他リンク:： https://ndlsearch.ndl.go.jp/books/R000000004-I033542157

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献体脳におけるアルツハイマー病理と認知機能に関する研究

中野正子, 小林英司, 永石歓和, 久原真, 藤宮峯子

臨床神経学 64 ( 6 ) 431 - 431 2024年6月

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記述言語：日本語出版者・発行元：(一社)日本神経学会

医中誌

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Mesenchymal stem cellsを知る—特集最新医療に向け新薬の標的を知る

永石歓和, 仲瀬裕志

消化器病学サイエンス = Science of gastroenterology / 「消化器病学サイエンス」編集委員会編 7 ( 1 ) 33 - 38 2023年3月

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記述言語：日本語出版者・発行元：東京 : 先端医学社

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間葉系幹細胞を用いた炎症性疾患の細胞治療—Cell therapy for inflammatory disease using mesenchymal stem cells

永石歓和

Bio clinica = バイオクリニカ 37 ( 12 ) 1155 - 1158 2022年11月

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記述言語：日本語出版者・発行元：東京 : 北隆館

その他リンク:： https://ndlsearch.ndl.go.jp/books/R000000004-I032642136

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細胞ファイバ技術によりスフェロイド化した間葉系幹細胞の特性と炎症抑制効果の検討

永石歓和, 池田和弘

北海道外科雑誌 67 ( 1 ) 93 - 94 2022年6月

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記述言語：日本語出版者・発行元：北海道外科学会

医中誌

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間葉系幹細胞を用いた炎症性疾患の細胞治療

永石歓和, 仲瀬裕志

BIO Clinica 37 87 - 90 2022年

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閉経後骨粗鬆症に対する間葉系幹細胞治療—Mesenchymal stem cell therapy for postmenopausal osteoporosis—研究者の最新動向査読

永石歓和, 齋藤憲, 射場浩介

Precision medicine = プレシジョンメディシン / 「Precision medicine」編集委員会編 4 ( 5 ) 509 - 513 2021年5月

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記述言語：日本語出版者・発行元：東京 : 北隆館

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賦活化した間葉系幹細胞による閉経後骨粗鬆症の細胞治療査読

永石歓和, 射場浩介

別冊BIO Clinica 10 144 - 148 2021年

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骨粗鬆症に対する間葉系幹細胞治療

齋藤憲, 永石歓和, 射場浩介

BIO Clinica 35 ( 7 ) 663 - 667 2020年7月

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記述言語：日本語出版者・発行元：(株)北隆館

医中誌

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骨粗鬆症に対する間葉系幹細胞治療査読

永石歓和, 射場浩介

BIO Clinica 35 655 - 659 2020年

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CiNii Research

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閉経後骨粗鬆症モデルラットに対する賦活化骨髄間葉系幹細胞の治療効果

齋藤憲, 齋藤憲, 永石歓和, 射場浩介, 山下敏彦, 藤宮峯子

北海道整形災害外科学会雑誌 61 ( 1 ) 10‐18 2019年8月

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記述言語：日本語

J-GLOBAL

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閉経後骨粗鬆症モデルラットに対する賦活化骨髄間葉系幹細胞の治療効果

齋藤憲, 永石歓和, 射場浩介, 山下敏彦, 藤宮峯子

北海道整形災害外科学会雑誌 61 ( 1 ) 10 - 18 2019年8月

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記述言語：日本語出版者・発行元：北海道整形災害外科学会

医中誌

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学術奨励賞・受賞記念論文閉経後骨粗鬆症モデルラットに対する賦活化骨髄間葉系幹細胞の治療効果

齊藤憲, 永石歓和, 射場浩介, 山下敏彦, 藤宮峯子

北海道整形災害外科学会雑誌 = The Hokkaido journal of orthopaedics and traumatology : 北海道整形災害外科学会機関誌 61 ( 1 ) 10 - 18 2019年8月

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記述言語：日本語出版者・発行元：[札幌] : 北海道整形災害外科学会

CiNii Research

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卵巣摘出閉経後骨粗鬆症モデルラットに対する賦活化骨髄間葉系幹細胞治療の有効性と機序解析

永石歓和, 藤宮峯子, 齋藤憲, 射場浩介, 山下敏彦

北海道外科雑誌 64 ( 1 ) 100 2019年6月

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記述言語：日本語

J-GLOBAL

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卵巣摘出閉経後骨粗鬆症モデルラットに対する賦活化骨髄間葉系幹細胞治療の有効性と機序解析

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北海道整形災害外科学会雑誌 60 ( 1 ) 144 - 144 2018年8月

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卵巣摘出閉経後骨粗鬆症モデルラットに対する賦活化骨髄間葉系幹細胞療法の有効性と機序解析

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日本再生医療学会総会(Web) 17th ROMBUNNO.O‐10‐1 (WEB ONLY) 2018年

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Dementia Japan 31 ( 4 ) 573 - 573 2017年10月

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日本整形外科学会雑誌 91 ( 8 ) S1569 2017年8月

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閉経後骨粗鬆症モデルラットに対する賦活化骨髄間葉系幹細胞療法の有効性と機序解析

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日本整形外科学会雑誌 91 ( 8 ) S1569 - S1569 2017年8月

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記述言語：日本語出版者・発行元：(公社)日本整形外科学会

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日本骨代謝学会学術集会プログラム抄録集 35回 196 - 196 2017年7月

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月刊メディカル・サイエンス・ダイジェスト 43 ( 2 ) 72‐75 2017年2月

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医中誌

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北海道整形災害外科学会雑誌 54 ( 1 ) 72 - 72 2012年8月

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日本骨代謝学会学術集会プログラム抄録集 30回 245 - 245 2012年7月

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GASTROENTEROLOGY 142 ( 5 ) S333 - S333 2012年5月

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消化器と免疫 ( 48 ) 30 - 35 2012年3月

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記述言語：日本語出版者・発行元：日本消化器免疫学会

医中誌

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意識下無拘束ラットにおいてコミュニケーションボックスによる慢性心理ストレスは結腸運動亢進を誘発する

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解剖学雑誌 86 ( 1 ) 11 - 11 2011年3月

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記述言語：日本語出版者・発行元：(一社)日本解剖学会

医中誌

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Flagellin特異的IgGの腸炎における役割 FcRnの抗原提示能の関与

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解剖学雑誌 85 ( 2 ) 59 - 59 2010年6月

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記述言語：日本語出版者・発行元：(一社)日本解剖学会

医中誌

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ACL大腿骨付着部軟骨下骨の骨梁構造

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解剖学雑誌 85 ( 2 ) 55 - 55 2010年6月

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記述言語：日本語出版者・発行元：(一社)日本解剖学会

医中誌

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Flagellin特異的IgGの腸炎における役割 FcRnによる抗原提示能の関与

永石歓和, ブルンバーグ・リチャード, 鈴木大輔, 藤宮峯子

解剖学雑誌 85 ( Suppl. ) 140 - 140 2010年3月

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記述言語：日本語出版者・発行元：(一社)日本解剖学会

医中誌

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肝内胆管粘液癌の一例

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日本消化器病学会雑誌 106 ( 臨増総会 ) A490 - A490 2009年3月

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記述言語：日本語出版者・発行元：(一財)日本消化器病学会

医中誌

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消化器疾患における自然免疫・獲得免疫のクロストーク Flagellin特異的IgGはFcRn依存性にマウス腸炎を促進する

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消化器と免疫 ( 45 ) 42 - 46 2009年3月

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記述言語：日本語出版者・発行元：日本消化器免疫学会

医中誌

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Anti-flagellin specific IgG is pathogenic in colitis through FcRn-regulated antigen presentation pathways

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GASTROENTEROLOGY 134 ( 4 ) A156 - A156 2008年4月

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記述言語：英語掲載種別：研究発表ペーパー・要旨（国際会議）

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日本消化管学会総会学術集会プログラム・抄録集 4th (Web) 2008年

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出願番号：特願2016-507805 出願日：2015年3月

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出願人：北海道公立大学法人札幌医科大学

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出願人：北海道公立大学法人札幌医科大学

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出願人：株式会社バイオミメティクスシンパシーズ

出願番号：特願2011-155142 出願日：2011年7月

公開番号：特開2013-018756 公開日：2013年1月

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