Education 【 display / non-display 】

Education 【 display / non-display 】

• 2013

  -

  2016

  Northwestern University   Feinberg School of Medicine - Northwestern University  

  　View Summary

  postdoctoral fellowship

• 1999

  -

  2005

  Sapporo Medical University   School of Medicine  

Research Experience 【 display / non-display 】

Research Experience 【 display / non-display 】

• 2025.04

  -

  Now

  Sapporo Medical University   Division of Cellular Physiology and Signal Transduction, Department of Physiology / Department of Cardiovascular-Kidney-Metabolic Medicine, Department of Internal Medicine.   Associate Professor

• 2024.01

  -

  2025.03

  Sapporo Medical University   School of Medicine   Associate Professor

• 2022.03

  -

  2023.12

  Sapporo Medical University   School of Medicine Medical Sciences   Assistant Professor

• 2017.04

  -

  2022.02

  Sapporo Medical University   Department of Cellular Physiology and Signal Transduction   Assistant Professor

• 2013.10

  -

  2016.03

  Northwestern University Feinberg Cardiovascular Research Institute   Postdoctoral Research Fellow

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Professional Memberships 【 display / non-display 】

Professional Memberships 【 display / non-display 】

• 2024.04

  -

  Now

  日本高血圧学会

• 2024.04

  -

  Now

  日本動脈硬化学会

• 2023.04

  -

  Now

  日本肥満学会

• 2022.04

  -

  Now

  日本内分泌学会

• 2019

  -

  Now

  日本医師会

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Research Areas 【 display / non-display 】

Research Areas 【 display / non-display 】

• Life sciences   Nephrology  

• Life sciences   Physiology  

• Life sciences   Cardiology  

• Life sciences   Metabolism and endocrinology  

Affiliation 【 display / non-display 】

Affiliation 【 display / non-display 】

• Sapporo Medical University   Department of Cellular Physiology and Signal Transduction, School of Medicine   Associate Professor  

Research Interests 【 display / non-display 】

Research Interests 【 display / non-display 】

• Cardioprotection

• Electrophysiology

• Bioinformatics

• Diabetic cardiomyopathy

• 糖尿病慢性合併症

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Papers 【 display / non-display 】

Papers 【 display / non-display 】

• Effects of contraction frequency during high-intensity training on fatigue resistance and aerobic adaptations in mouse skeletal muscle.

  Azuma Naito, Tatsuya Sato, Iori Kimura, Nao Tokuda, Nao Yamauchi, Hiroyori Fusagawa, Takashi Yamada

  Journal of applied physiology (Bethesda, Md. : 1985)    2024.12  [Refereed]  [International journal]

  Authorship：   Lead author

  　View Summary

  In high-intensity and sprint interval training, the frequency of contractions is typically higher compared to moderate-intensity continuous training, but it remains unclear whether this contributes to the effective increase in fatigue resistance mechanisms. Here, we investigated the role of contraction frequency in high-intensity training on endurance adaptations of mouse skeletal muscle. Male C57BL/6 mice were divided into groups based on high (0.25 s contraction every 0.5 s) and low (0.25 s contraction every 4.5 s) contraction frequencies, with either 360 contractions per session (Hi360 and Lo360) or 30 contractions per session (Hi30 and Lo30). The plantar flexor muscles were stimulated using in vivo supramaximal electrical stimulation, where all muscle fibers were maximally activated, every other day for 5 weeks. In both the Hi360 and Lo360 groups, where force production declined to less than 40% of the initial value during the training session, muscle endurance, as well as mitochondrial content and respiratory capacity, were increased to a similar extent. In contrast, the rate of torque decline during the training session was more pronounced in the Hi30 group compared to the Lo30 group. In response, the Hi30 group, but not the Lo30 group, exhibited increased fatigue resistance and mitochondrial respiration, which was accompanied by increased PGC-1α expression and an activation of AMPK/Ulk1 pathway. These data suggest that the frequency of contractions is a critical factor in determining the efficient enhancement of mitochondrial respiratory capacity and muscle endurance through high-intensity training, presumably due to promotion of mitochondrial quality control.

  DOI PubMed

• A silent interplay between elevated intraocular pressure, glaucoma, and hypertension.

  Tatsuya Sato, Araya Umetsu, Marenao Tanaka, Hiroshi Ohguro, Masato Furuhashi

  Hypertension research : official journal of the Japanese Society of Hypertension    2024.12  [Refereed]  [International journal]

  Authorship：   Lead author

  DOI PubMed

• High Intraocular Pressure Is Independently Associated With New-Onset Systemic Hypertension Over a 10-Year Period

  Araya Umetsu, Marenao Tanaka, Tatsuya Sato, Yukinori Akiyama, Keisuke Endo, Kazuma Mori, Hirofumi Ohnishi, Megumi Watanabe, Hiroshi Ohguro, Nagisa Hanawa, Masato Furuhashi

  Circulation Journal ( Japanese Circulation Society )   2024.07  [Refereed]

  Authorship：   Lead author

  DOI

• FABP4 Is an Indispensable Factor for Regulating Cellular Metabolic Functions of the Human Retinal Choroid.

  Hiroshi Ohguro, Megumi Watanabe, Tatsuya Sato, Nami Nishikiori, Araya Umetsu, Megumi Higashide, Toshifumi Ogawa, Masato Furuhashi

  Bioengineering (Basel, Switzerland)   11 ( 6 )  2024.06  [Refereed]  [International journal]

  Authorship：   Corresponding author

  　View Summary

  The purpose of the current study was to elucidate the physiological roles of intraocularly present fatty acid-binding protein 4 (FABP4). Using four representative intraocular tissue-derived cell types, including human non-pigmented ciliary epithelium (HNPCE) cells, retinoblastoma (RB) cells, adult retinal pigment epithelial19 (ARPE19) cells and human ocular choroidal fibroblast (HOCF) cells, the intraocular origins of FABP4 were determined by qPCR analysis, and the intracellular functions of FABP4 were investigated by seahorse cellular metabolic measurements and RNA sequencing analysis using a specific inhibitor for FABP4, BMS309403. Among these four different cell types, FABP4 was exclusively expressed in HOCF cells. In HOCF cells, both mitochondrial and glycolytic functions were significantly decreased to trace levels by BMS309403 in a dose-dependent manner. In the RNA sequencing analysis, 67 substantially up-regulated and 94 significantly down-regulated differentially expressed genes (DEGs) were identified in HOCF cells treated with BMS309403 and those not treated with BMS309403. The results of Gene Ontology enrichment analysis and ingenuity pathway analysis (IPA) revealed that the DEGs were most likely involved in G-alpha (i) signaling, cAMP-response element-binding protein (CREB) signaling in neurons, the S100 family signaling pathway, visual phototransduction and adrenergic receptor signaling. Furthermore, upstream analysis using IPA suggested that NKX2-1 (thyroid transcription factor1), HOXA10 (homeobox A10), GATA2 (gata2 protein), and CCAAT enhancer-binding protein A (CEBPA) were upstream regulators and that NKX homeobox-1 (NKX2-1), SFRP1 (Secreted frizzled-related protein 1) and TREM2 (triggering receptor expressed on myeloid cells 2) were causal network master regulators. The findings in this study suggest that intraocularly present FABP4 originates from the ocular choroid and may be a critical regulator for the cellular homeostasis of non-adipocyte HOCF cells.

  DOI PubMed

• The Specific ROCK2 Inhibitor KD025 Alleviates Glycolysis through Modulating STAT3-, CSTA- and S1PR3-Linked Signaling in Human Trabecular Meshwork Cells.

  Megumi Watanabe, Tatsuya Sato, Araya Umetsu, Toshifumi Ogawa, Nami Nishikiori, Megumi Suzuki, Masato Furuhashi, Hiroshi Ohguro

  Biomedicines   12 ( 6 )  2024.05  [Refereed]  [International journal]

  Authorship：   Lead author

  　View Summary

  To investigate the biological significance of Rho-associated coiled-coil-containing protein kinase (ROCK) 2 in the human trabecular meshwork (HTM), changes in both metabolic phenotype and gene expression patterns against a specific ROCK2 inhibitor KD025 were assessed in planar-cultured HTM cells. A seahorse real-time ATP rate assay revealed that administration of KD025 significantly suppressed glycolytic ATP production rate and increased mitochondrial ATP production rate in HTM cells. RNA sequencing analysis revealed that 380 down-regulated and 602 up-regulated differentially expressed genes (DEGs) were identified in HTM cells treated with KD025 compared with those that were untreated. Gene ontology analysis revealed that DEGs were more frequently related to the plasma membrane, extracellular components and integral cellular components among cellular components, and related to signaling receptor binding and activity and protein heterodimerization activity among molecular functions. Ingenuity Pathway Analysis (IPA) revealed that the detected DEGs were associated with basic cellular biological and physiological properties, including cellular movement, development, growth, proliferation, signaling and interaction, all of which are associated with cellular metabolism. Furthermore, the upstream regulator analysis and causal network analysis estimated IL-6, STAT3, CSTA and S1PR3 as possible regulators. Current findings herein indicate that ROCK2 mediates the IL-6/STAT3-, CSTA- and S1PR3-linked signaling related to basic biological activities such as glycolysis in HTM cells.

  DOI PubMed

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Books and Other Publications 【 display / non-display 】

Books and Other Publications 【 display / non-display 】

• 札幌市内科医会会報 第32号 SGLT2阻害薬からみえてきた心･腎･代謝領域の新しい生理学的知見～ 基礎医学から臨床データを視る ～

  Tatsuya Sato( Part： Other, 研修会会議録)

  札幌市医師会  2025.08

• 月刊糖尿病#153 糖尿病患者の救急医療・急性期医療

  佐藤達也, 古橋眞人( Part： Contributor, Chapter 7 心血管疾患・心不全)

  IGAKU-SHUPPAN  2024.05

• Diagnosis and Treatment

  Tatsuya Sato, Masato Furuhashi( Part： Contributor, 治療、管理～心血管イベントの管理～)

  診断と治療社  2023.12

• INTENSIVE CCARE MEDICINE

  Tatsuya Sato( Part： Contributor, Chapter 1 入門細胞生物学～細胞機能総論～)

  Gakken  2023.05

• 北海道の健康をささえる 札幌医科大学附属病院の最新医療

  Tatsuya Sato( Part： Contributor, Q16 糖尿病24時間監視の試み)

  バリューメディカル  2022.03

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Misc 【 display / non-display 】

Misc 【 display / non-display 】

• セマグルチド注射薬により20年間のインスリン強化療法から離脱できた2型糖尿病の1例

  寺沢 誠, 中田 圭, 大久保 武志, 小川 俊史, 隅田 健太郎, 佐藤 達也, 神津 英至, 矢野 俊之, 古橋 眞人

  糖尿病 ( (一社)日本糖尿病学会 )  67 ( 12 ) 511 - 511  2024.12

• 脈管分野において人工知能が果たす役割 Graph based clusteringを用いた腹部大動脈瘤拡大因子としての濾胞関連新規リンパ球サブセットの同定と機能的意義の解明

  保坂 到, 池上 一平, 三上 拓真, 佐藤 達也, 小川 俊文, 田中 希尚, 遠藤 圭佑, 秋山 幸功, 大川 陽史, 仲澤 順二, 柴田 豪, 中島 智博, 伊庭 裕, 高野 賢一, 一宮 慎吾, 川原田 修義, 古橋 眞人

  脈管学 ( (一社)日本脈管学会 )  64 ( Suppl. ) S114 - S114  2024.10

• 腹部大動脈瘤拡大因子としての瘤壁三次リンパ組織形成および濾胞関連新規リンパ球サブセットの解明

  保坂 到, 池上 一平, 三上 拓真, 佐藤 達也, 小川 俊文, 武川 慶, 田中 希尚, 遠藤 圭佑, 秋山 幸功, 大川 陽史, 仲澤 順二, 柴田 豪, 中島 智博, 伊庭 裕, 高野 賢一, 一宮 慎吾, 川原田 修義, 古橋 眞人

  脈管学 ( (一社)日本脈管学会 )  64 ( Suppl. ) S149 - S150  2024.10

• 慢性腎臓病と代謝異常関連脂肪肝疾患(MAFLD)との合併は虚血性心疾患の発症リスクを増加させる

  宮森 大輔, 田中 希尚, 佐藤 達也, 遠藤 圭佑, 森 和真, 塙 なぎさ, 大西 浩文, 古橋 眞人

  日本腎臓学会誌 ( (一社)日本腎臓学会 )  66 ( 4 ) 652 - 652  2024.06

• Sampsonの式あるいは人工知能を用いて推定したsmall dense LDLコレステロール値の精度の検証

  大久保 武志, 遠藤 圭佑, 田中 希尚, 佐藤 達也, 小林 亮, 田中 真輝人, 秋山 幸功, 保坂 到, 中田 圭, 小山 雅之, 大西 浩文, 高橋 聡, 古橋 眞人

  糖尿病 ( (一社)日本糖尿病学会 )  67 ( Suppl.1 ) S - 251  2024.04

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Awards 【 display / non-display 】

Awards 【 display / non-display 】

• 第1回日本循環器学会基礎研究フォーラム Poster Award

  2018.01   The Japanese Circulation Society   Tristetraprolin prevents iron deficiency-induced ROS production by optimizing expression of UQCRFS1.

• 第34回ISHR日本部会 YIA優秀賞

  2017.12   International Society for Heart Research（ISHR）Japanese Section of ISHR   A novel role of tristetraprolin in regulation of reactive oxygen species production by optimizing iron containing proteins

• 第21回日本心不全学会学術集会 基礎の部 YIA優秀賞

  2017.10   The Japanese Heart Failure Society   Tristetraprolin-mediated regulation of Rieske, a mitochondrial complex III protein, protects the heart against iron deficiency.

• FCVB - European Society of Cardiology 2016 Moderated Poster Award

  2016.07   European Society of Cardiology   A novel role of tristetraprolin in preventing mitochondrial dysfunction in the heart against iron deficiency by optimizing expression of Rieske iron-sulfur protein

• Role of heme and mitochondrial iron in the development of heart failure

  2015.01   AHA Award MWA Summer 2014 Postdoctoral Fellowship   Role of heme and mitochondrial iron in the development of heart failure

  Winner： Tatsuya Sato

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Research Projects 【 display / non-display 】

Research Projects 【 display / non-display 】

• 心停止後臓器提供のドナー心におけるSGLT1阻害作用の臓器保護効果の機序探索

  Grant-in-Aid for Scientific Research (C)

  Project Year :

  2025.04

  -

  2028.03

   

  Yuma Sato, Yusuke Yoshikawa, Tatsuya Sato

  Authorship： Coinvestigator(s)

• Roles of Ferroptosis in Steatotic Liver Disease as a Pathophysiology of Cardiovascular, Kidney, and Metabolic (CKM) Syndrome

  Grant-in-Aid for Scientific Research (C)

  Project Year :

  2025.04

  -

  2028.03

   

  Tatsuya Sato, Megumi Watanabe, Nobutoshi Ichise, Toshifumi Ogawa

  Authorship： Principal investigator

• Elucidating the mechanisms of diabetes-induced skeletal muscle atrophy; effects of metabolic rewiring by AMPD3 on energy metabolism.

  Project Year :

  2024.07

  　

  　

   

  Toshifumi Ogawa, Hidemichi Kouzu, Tatsuya Sato

  Authorship： Coinvestigator(s)

• Establishment of new treatment method for dedifferentiated chondrosarcoma

  Grant-in-Aid for Scientific Research (C)

  Project Year :

  2024.04

  -

  2027.03

   

  清水 淳也, 高澤 啓, 江森 誠人, 房川 祐頼, 佐藤 達也, 高田 弘一, 中橋 尚也

• 心筋分岐鎖アミノ酸代謝を標的とした心不全治療の開発

  基盤研究(C)

  Project Year :

  2023.04

  -

  2026.03

   

  神津 英至, 久野 篤史, 佐藤 達也

  　View Summary

  申請者らはラット心筋細胞において、分枝鎖アミノ酸(BCAA)の代謝律速酵素である分枝鎖α-ケト酸脱水素酵素(BCKDH)がミトコンドリアのみならず筋小胞体に高発現し、AMP deaminase 3(AMPD3)との直接結合にて活性修飾を受けていること、AMPD3-BCKDHの発現不均衡が糖尿病性心筋症の発症に関与していることを最近報告した。本研究においてこれまで、BCKDHの筋小胞体における高発現およびAMPD3との直接結合がマウスの心筋でも再現されることを確認した。さらに、AMPD1が主要なアイソフォームとされる骨格筋において、下肢挙上による筋萎縮の誘導がAMPD3の発現を有意に上昇させること、BCKDHがAMPD1とではなくAMPD3と直接結合していることを同定した。これらの結果から、筋組織のBCAA代謝におけるAMPD3の特異的な役割が示唆された。 AMPD3全身ノックアウトマウスは、非負荷時には明らかな表現型を認めなかったが、横行大動脈縮窄(TAC)による心不全の誘導が増悪する傾向にあった。一方、下肢挙上による筋萎縮の誘導においては、AMPD3欠損により前脛骨筋およびヒラメ筋の筋重量減少が抑制される傾向がみられた。これらの結果から、AMPD3の欠損により誘導される代謝変化の影響は、心筋と骨格筋では異なる可能性が示唆された。 臨床研究では、心不全症例において末梢血アミノ酸プロファイリングを行い、BCAAを含む予後不良なアミノ酸プロファイルが、骨格筋の脂肪変性と関連することを見出した。 また、糖尿病性心筋症におけるAMPD3の関与について、申請者らのこれまでの報告をまとめ、総説を発表した。

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Presentations 【 display / non-display 】

Presentations 【 display / non-display 】

• ダイアベティスケアのイロハ：血管障害「診療現場の工夫と英知で乗り越えてきた成果と、血管合併症撲滅のための新視点」

  佐藤 達也  [Invited]

  第12回JADEC年次学術集会 

  Presentation date： 2025.07

  Event date：

  2025.07

  　

  　

• 日本動脈硬化学会・日本肝臓学会合同シンポジウムMASLD/MASHと心血管疾患・脂質異常症 MASLDが虚血性心疾患および慢性腎臓病の発症に及ぼす影響

  佐藤 達也

  第57回日本動脈硬化学会総会・学術集会 

  Presentation date： 2025.07

  Event date：

  2025.07

  　

  　

• SGLT2阻害薬からみえてきた心･腎･代謝領域の新しい生理学的知見～基礎医学から臨床データを視る～

  佐藤 達也  [Invited]

  日本医師会生涯教育講座／2024年第3回札幌市内科医会研修会 

  Presentation date： 2024.12

  Event date：

  2024.12

  　

  　

• オルガネラ間クロストークの異常から視る糖尿病性心腎血管合併症の病態 ～ レドックス－核酸代謝連関を標的とした治療戦略 ～

  Tatsuya Sato  [Invited]

  第47回 日本分子生物学会年会 

  Presentation date： 2024.11

  Event date：

  2024.11

  　

  　

• 新時代を迎えた糖尿病診療における早期介入と治療継続の重要性 ~臨床と基礎の両面からのアプローチ~

  佐藤 達也  [Invited]

  ダイアベティスセミナー in 根室 日本医師会生涯教育講座（根室市外三群医師会／根室薬剤師会／根室病院薬剤師会） 

  Presentation date： 2024.11

  Event date：

  2024.11

  　

  　

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Teaching Experience 【 display / non-display 】

Teaching Experience 【 display / non-display 】

• 生体機能形態学(II)  

  札幌医科大学医学専攻科 修士課程  

  2021.04

  -

  Now

   

• Physiology  

  Japan Healthcare University  

  2021.04

  -

  Now

   

• Pathophysiology  

  Japan Healthcare University  

  2018.04

  -

  2021.03

   

• Introduction to Clinical Practice - Basics of 12-lead ECG and Monitor ECG  

  Sappro Medical University School of Medicine  

  2018.04

  -

  2020.04

   

• Physiology  

  Sapporo Medical University School of Medicine  

  2017.04

  -

  Now

   

Committee Memberships 【 display / non-display 】

Committee Memberships 【 display / non-display 】

• 2024.07

  -

  Now

    Frontiers in Cardiovascular Medicine Associate Editor

• 2024.04

  -

  Now

    The board of physiological education

• 2024.04

  -

  Now

    organizer

• 2023.07

  -

  Now

    Frontiers in Physiology Reviewing Editor

• 2023.04

  -

  Now

    医学系CBT実施管理委員会 機構派遣監督者専門部会 委員

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Social Activities 【 display / non-display 】

Social Activities 【 display / non-display 】

• 医学部へようこそ！ ～未知なる宇宙であるヒトの身体を知る学問～

  立命館慶祥中学校  キャリア講演会 

  2023.07

  　

  　

• ゲストティーチャー（お医者さんと研究者のお仕事）

  札幌市立円山小学校 

  2023.02

  　

  　

• 糖尿病重症化予防プロジェクト

  江差保健所 

  2013.09

  　

  　

• 高校生メディカル講座（北海道室蘭栄高等学校）

  北海道教育委員会 

  2012.10

  　

  　

• 高校生メディカル講座（北海道札幌北高等学校）

  札幌医科大学 

  2012.01

  　

  　

Academic Activities 【 display / non-display 】

Academic Activities 【 display / non-display 】

• 第24回日本内分泌学会北海道支部学術集会

  Academic society, research group, etc.

  会長 古橋 眞人  

  2024.10

  　

  　

• 第57回日本糖尿病学会北海道地方会

  Academic society, research group, etc.

  会長 古橋 眞人  

  2023.10

  　

  　

• 第100回北海道医学大会生理系分科会

  Academic society, research group, etc.

  会長 當瀬 規嗣  

  2020.08

  　

  　

• 第34回国際心臓研究学会（ISHR）日本部会 事務局

  Academic society, research group, etc.

  会長 三浦 哲嗣  

  2017.12