Education 【 display / non-display 】

Education 【 display / non-display 】

• 2013

  -

  2016

  Northwestern University   Feinberg School of Medicine - Northwestern University  

  　View Summary

  postdoctoral fellowship

• 1999

  -

  2005

  Sapporo Medical University   School of Medicine  

Research Experience 【 display / non-display 】

Research Experience 【 display / non-display 】

• 2024.01

  -

  Now

  Sapporo Medical University   School of Medicine   Associate Professor

• 2022.03

  -

  2023.12

  Sapporo Medical University   School of Medicine Medical Sciences   Assistant Professor

• 2017.04

  -

  2022.03

  Sapporo Medical University   Department of Cellular Physiology and Signal Transduction   Assistant Professor

• 2013.10

  -

  2016.03

  Northwestern University Feinberg Cardiovascular Research Institute   Postdoctoral Research Fellow

• 2011.04

  -

  2013.03

  Sapporo Medical University School of Medicine   Department of Cellular Physiology and Signal Transduction   Assistant Professor

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Professional Memberships 【 display / non-display 】

Professional Memberships 【 display / non-display 】

• 2024.04

  -

  Now

  日本動脈硬化学会

• 2024.04

  -

  Now

  日本高血圧学会

• 2023.04

  -

  Now

  日本肥満学会

• 2022.04

  -

  Now

  日本内分泌学会

• 2019

  -

  Now

  日本医師会

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Research Areas 【 display / non-display 】

Research Areas 【 display / non-display 】

• Life sciences   Nephrology  

• Life sciences   Physiology  

• Life sciences   Cardiology  

• Life sciences   Metabolism and endocrinology  

Affiliation 【 display / non-display 】

Affiliation 【 display / non-display 】

• Sapporo Medical University   Department of Cellular Physiology and Signal Transduction, School of Medicine   Associate Professor  

Research Interests 【 display / non-display 】

Research Interests 【 display / non-display 】

• Electrophysiology

• Cardioprotection

• Mitochondrial function

• 運動・筋生理学

• 糖尿病慢性合併症

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Papers 【 display / non-display 】

Papers 【 display / non-display 】

• Effects of contraction frequency during high-intensity training on fatigue resistance and aerobic adaptations in mouse skeletal muscle.

  Azuma Naito, Tatsuya Sato, Iori Kimura, Nao Tokuda, Nao Yamauchi, Hiroyori Fusagawa, Takashi Yamada

  Journal of applied physiology (Bethesda, Md. : 1985)    2024.12  [Refereed]  [International journal]

  Authorship：   Lead author

  　View Summary

  In high-intensity and sprint interval training, the frequency of contractions is typically higher compared to moderate-intensity continuous training, but it remains unclear whether this contributes to the effective increase in fatigue resistance mechanisms. Here, we investigated the role of contraction frequency in high-intensity training on endurance adaptations of mouse skeletal muscle. Male C57BL/6 mice were divided into groups based on high (0.25 s contraction every 0.5 s) and low (0.25 s contraction every 4.5 s) contraction frequencies, with either 360 contractions per session (Hi360 and Lo360) or 30 contractions per session (Hi30 and Lo30). The plantar flexor muscles were stimulated using in vivo supramaximal electrical stimulation, where all muscle fibers were maximally activated, every other day for 5 weeks. In both the Hi360 and Lo360 groups, where force production declined to less than 40% of the initial value during the training session, muscle endurance, as well as mitochondrial content and respiratory capacity, were increased to a similar extent. In contrast, the rate of torque decline during the training session was more pronounced in the Hi30 group compared to the Lo30 group. In response, the Hi30 group, but not the Lo30 group, exhibited increased fatigue resistance and mitochondrial respiration, which was accompanied by increased PGC-1α expression and an activation of AMPK/Ulk1 pathway. These data suggest that the frequency of contractions is a critical factor in determining the efficient enhancement of mitochondrial respiratory capacity and muscle endurance through high-intensity training, presumably due to promotion of mitochondrial quality control.

  DOI PubMed

• A silent interplay between elevated intraocular pressure, glaucoma, and hypertension.

  Tatsuya Sato, Araya Umetsu, Marenao Tanaka, Hiroshi Ohguro, Masato Furuhashi

  Hypertension research : official journal of the Japanese Society of Hypertension    2024.12  [Refereed]  [International journal]

  Authorship：   Lead author

  DOI PubMed

• High Intraocular Pressure Is Independently Associated With New-Onset Systemic Hypertension Over a 10-Year Period

  Araya Umetsu, Marenao Tanaka, Tatsuya Sato, Yukinori Akiyama, Keisuke Endo, Kazuma Mori, Hirofumi Ohnishi, Megumi Watanabe, Hiroshi Ohguro, Nagisa Hanawa, Masato Furuhashi

  Circulation Journal ( Japanese Circulation Society )   2024.07  [Refereed]

  Authorship：   Lead author

  DOI

• FABP4 Is an Indispensable Factor for Regulating Cellular Metabolic Functions of the Human Retinal Choroid.

  Hiroshi Ohguro, Megumi Watanabe, Tatsuya Sato, Nami Nishikiori, Araya Umetsu, Megumi Higashide, Toshifumi Ogawa, Masato Furuhashi

  Bioengineering (Basel, Switzerland)   11 ( 6 )  2024.06  [Refereed]  [International journal]

  Authorship：   Corresponding author

  　View Summary

  The purpose of the current study was to elucidate the physiological roles of intraocularly present fatty acid-binding protein 4 (FABP4). Using four representative intraocular tissue-derived cell types, including human non-pigmented ciliary epithelium (HNPCE) cells, retinoblastoma (RB) cells, adult retinal pigment epithelial19 (ARPE19) cells and human ocular choroidal fibroblast (HOCF) cells, the intraocular origins of FABP4 were determined by qPCR analysis, and the intracellular functions of FABP4 were investigated by seahorse cellular metabolic measurements and RNA sequencing analysis using a specific inhibitor for FABP4, BMS309403. Among these four different cell types, FABP4 was exclusively expressed in HOCF cells. In HOCF cells, both mitochondrial and glycolytic functions were significantly decreased to trace levels by BMS309403 in a dose-dependent manner. In the RNA sequencing analysis, 67 substantially up-regulated and 94 significantly down-regulated differentially expressed genes (DEGs) were identified in HOCF cells treated with BMS309403 and those not treated with BMS309403. The results of Gene Ontology enrichment analysis and ingenuity pathway analysis (IPA) revealed that the DEGs were most likely involved in G-alpha (i) signaling, cAMP-response element-binding protein (CREB) signaling in neurons, the S100 family signaling pathway, visual phototransduction and adrenergic receptor signaling. Furthermore, upstream analysis using IPA suggested that NKX2-1 (thyroid transcription factor1), HOXA10 (homeobox A10), GATA2 (gata2 protein), and CCAAT enhancer-binding protein A (CEBPA) were upstream regulators and that NKX homeobox-1 (NKX2-1), SFRP1 (Secreted frizzled-related protein 1) and TREM2 (triggering receptor expressed on myeloid cells 2) were causal network master regulators. The findings in this study suggest that intraocularly present FABP4 originates from the ocular choroid and may be a critical regulator for the cellular homeostasis of non-adipocyte HOCF cells.

  DOI PubMed

• The Specific ROCK2 Inhibitor KD025 Alleviates Glycolysis through Modulating STAT3-, CSTA- and S1PR3-Linked Signaling in Human Trabecular Meshwork Cells.

  Megumi Watanabe, Tatsuya Sato, Araya Umetsu, Toshifumi Ogawa, Nami Nishikiori, Megumi Suzuki, Masato Furuhashi, Hiroshi Ohguro

  Biomedicines   12 ( 6 )  2024.05  [Refereed]  [International journal]

  Authorship：   Lead author

  　View Summary

  To investigate the biological significance of Rho-associated coiled-coil-containing protein kinase (ROCK) 2 in the human trabecular meshwork (HTM), changes in both metabolic phenotype and gene expression patterns against a specific ROCK2 inhibitor KD025 were assessed in planar-cultured HTM cells. A seahorse real-time ATP rate assay revealed that administration of KD025 significantly suppressed glycolytic ATP production rate and increased mitochondrial ATP production rate in HTM cells. RNA sequencing analysis revealed that 380 down-regulated and 602 up-regulated differentially expressed genes (DEGs) were identified in HTM cells treated with KD025 compared with those that were untreated. Gene ontology analysis revealed that DEGs were more frequently related to the plasma membrane, extracellular components and integral cellular components among cellular components, and related to signaling receptor binding and activity and protein heterodimerization activity among molecular functions. Ingenuity Pathway Analysis (IPA) revealed that the detected DEGs were associated with basic cellular biological and physiological properties, including cellular movement, development, growth, proliferation, signaling and interaction, all of which are associated with cellular metabolism. Furthermore, the upstream regulator analysis and causal network analysis estimated IL-6, STAT3, CSTA and S1PR3 as possible regulators. Current findings herein indicate that ROCK2 mediates the IL-6/STAT3-, CSTA- and S1PR3-linked signaling related to basic biological activities such as glycolysis in HTM cells.

  DOI PubMed

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Books and Other Publications 【 display / non-display 】

Books and Other Publications 【 display / non-display 】

• 月刊糖尿病#153 糖尿病患者の救急医療・急性期医療

  佐藤達也, 古橋眞人( Part： Contributor, Chapter 7 心血管疾患・心不全)

  IGAKU-SHUPPAN  2024.05

• Diagnosis and Treatment

  Tatsuya Sato, Masato Furuhashi( Part： Contributor, 治療、管理～心血管イベントの管理～)

  診断と治療社  2023.12

• INTENSIVE CCARE MEDICINE

  Tatsuya Sato( Part： Contributor, Chapter 1 入門細胞生物学～細胞機能総論～)

  Gakken  2023.05

• 北海道の健康をささえる 札幌医科大学附属病院の最新医療

  Tatsuya Sato( Part： Contributor, Q16 糖尿病24時間監視の試み)

  バリューメディカル  2022.03

• 月刊糖尿病#121 糖尿病と心不全～病態・治療・予防～

  Takayuki Miki, Tatsuya Sato( Part： Contributor, Chapter II 治療 血糖降下薬と心不全①メトホルミン、SU薬、グリニド、インスリン)

  Gakken  2020.01

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Misc 【 display / non-display 】

Misc 【 display / non-display 】

• Impact of Mitochondrial Dynamics on Necroptosis in Cardiomyocytes(タイトル和訳中)

  戸田 悠貴, 矢野 俊之, 久野 篤史, 丹野 雅也, 神津 英至, 佐藤 達也, 大和田 渉, 舘越 勇輝, 小川 俊史, 清水 将輝, 古橋 眞人

  日本循環器学会学術集会抄録集 ( (一社)日本循環器学会 )  88回   PJ080 - 3  2024.03

• Calculated Small Dense Low-density Lipoprotein Cholesterol by Sampson Equation is a Predominant Predictor for the Development of Ischemic Heart Disease(タイトル和訳中)

  印鑰 雅史, 佐藤 達也, 田中 希尚, 遠藤 圭佑, 保坂 到, 三上 拓真, 大西 浩文, 塙 なぎさ, 古橋 眞人

  日本循環器学会学術集会抄録集 ( (一社)日本循環器学会 )  88回   OJ03 - 2  2024.03

• Contribution of MLKL to the Development of Doxorubicin-induced Cardiomyopathy(タイトル和訳中)

  清水 将輝, 大和田 渉, 矢野 俊之, 神津 英至, 佐藤 達也, 長南 新太, 小川 俊史, 戸田 悠貴, 久野 篤史, 丹野 雅也, 古橋 眞人

  日本循環器学会学術集会抄録集 ( (一社)日本循環器学会 )  88回   PJ073 - 1  2024.03

• 眼圧高値は新規高血圧発症の危険因子である

  田中 希尚, 佐藤 達也, 塙 なぎさ, 梅津 新矢, 古橋 眞人

  日本内科学会雑誌 ( (一社)日本内科学会 )  113 ( 臨増 ) 173 - 173  2024.02

• パッチ式インスリンポンプとリアルタイムCGMを外来で導入し得た症例の検討

  吉田 十和, 古橋 眞人, 佐藤 達也

  糖尿病 ( (一社)日本糖尿病学会 )  67 ( 1 ) 41 - 41  2024.01

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Awards 【 display / non-display 】

Awards 【 display / non-display 】

• 第1回日本循環器学会基礎研究フォーラム Poster Award

  2018.01   The Japanese Circulation Society   Tristetraprolin prevents iron deficiency-induced ROS production by optimizing expression of UQCRFS1.

• 第34回ISHR日本部会 YIA優秀賞

  2017.12   International Society for Heart Research（ISHR）Japanese Section of ISHR   A novel role of tristetraprolin in regulation of reactive oxygen species production by optimizing iron containing proteins

• 第21回日本心不全学会学術集会 基礎の部 YIA優秀賞

  2017.10   The Japanese Heart Failure Society   Tristetraprolin-mediated regulation of Rieske, a mitochondrial complex III protein, protects the heart against iron deficiency.

• FCVB - European Society of Cardiology 2016 Moderated Poster Award

  2016.07   European Society of Cardiology   A novel role of tristetraprolin in preventing mitochondrial dysfunction in the heart against iron deficiency by optimizing expression of Rieske iron-sulfur protein

• 第90回 日本生理学会年次学術集会 佐川喜一賞

  2013.03   The Japan Physiological Society   Characteristics of Voltage Dependent Inward Currents in the Rat Embryonic Heart Early After the Initiation of Heartbeat

Research Projects 【 display / non-display 】

Research Projects 【 display / non-display 】

• Elucidating the mechanisms of diabetes-induced skeletal muscle atrophy; effects of metabolic rewiring by AMPD3 on energy metabolism.

  Project Year :

  2024.07

  　

  　

   

  Toshifumi Ogawa, Hidemichi Kouzu, Tatsuya Sato

  Authorship： Coinvestigator(s)

• Establishment of new treatment method for dedifferentiated chondrosarcoma

  Grant-in-Aid for Scientific Research (C)

  Project Year :

  2024.04

  -

  2027.03

   

  清水 淳也, 高澤 啓, 江森 誠人, 房川 祐頼, 佐藤 達也, 高田 弘一, 中橋 尚也

• 腎不全サルコペニアの運動時エネルギー代謝障害の解明と神経-筋電気刺激療法の確立

  基盤研究(C)

  Project Year :

  2023.04

  -

  2026.03

   

  房川 祐頼, 佐藤 達也, 山田 崇史

  Authorship： Coinvestigator(s)

• 血清DLL4、ACE-2がサルコペニアに与える影響の検討

  Project Year :

  2023.04

  -

  2024.03

   

  Keisuke Endo, Tatsuya Sato, Hirofumi Ohnishi, Masato Furuhashi

  Authorship： Coinvestigator(s)

• 低酸素誘導因子1α が胎生初期心臓原基の拍動開始および拍動維持に及ぼす影響の検討

  基盤研究(C)

  Project Year :

  2022.04

  -

  2025.03

   

  當瀬 規嗣, 佐藤 達也, 一瀬 信敏

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Presentations 【 display / non-display 】

Presentations 【 display / non-display 】

• SGLT2阻害薬からみえてきた心･腎･代謝領域の新しい生理学的知見～基礎医学から臨床データを視る～

  佐藤 達也  [Invited]

  日本医師会生涯教育講座／2024年第3回札幌市内科医会研修会 

  Presentation date： 2024.12

  Event date：

  2024.12

  　

  　

• オルガネラ間クロストークの異常から視る糖尿病性心腎血管合併症の病態 ～ レドックス－核酸代謝連関を標的とした治療戦略 ～

  Tatsuya Sato  [Invited]

  第47回 日本分子生物学会年会 

  Presentation date： 2024.11

  Event date：

  2024.11

  　

  　

• 新時代を迎えた糖尿病診療における早期介入と治療継続の重要性 ~臨床と基礎の両面からのアプローチ~

  佐藤 達也  [Invited]

  ダイアベティスセミナー in 根室 日本医師会生涯教育講座（根室市外三群医師会／根室薬剤師会／根室病院薬剤師会） 

  Presentation date： 2024.11

  Event date：

  2024.11

  　

  　

• 早期発見･介入の重要性を再考する～高血圧、糖尿病、脂質異常症の診療と研究の最前線から～

  Tatsuya Sato  [Invited]

  日本医師会生涯教育講座（旭川市医師会） 

  Presentation date： 2024.10

  Event date：

  2024.10

  　

  　

• 生理学の視点からSGLT2阻害薬の糖尿病･慢性腎臓病への影響を再考する

  Tatsuya Sato  [Invited]

  日本医師会生涯教育講座／Cardio Renal Management Seminar in Hokkaido 

  Presentation date： 2024.10

  Event date：

  2024.10

  　

  　

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Teaching Experience 【 display / non-display 】

Teaching Experience 【 display / non-display 】

• Physiology  

  Japan Healthcare University  

  2021.04

  -

  Now

   

• 生体機能形態学(II)  

  札幌医科大学医学専攻科 修士課程  

  2021.04

  -

  Now

   

• Pathophysiology  

  Japan Healthcare University  

  2018.04

  -

  2021.03

   

• Introduction to Clinical Practice - Basics of 12-lead ECG and Monitor ECG  

  Sappro Medical University School of Medicine  

  2018.04

  -

  2020.04

   

• Physiology  

  Sapporo Medical University School of Medicine  

  2017.04

  -

  Now

   

Committee Memberships 【 display / non-display 】

Committee Memberships 【 display / non-display 】

• 2024.07

  -

  Now

    Frontiers in Cardiovascular Medicine Associate Editor

• 2024.04

  -

  Now

    The board of physiological education

• 2024.04

  -

  Now

    organizer

• 2023.07

  -

  Now

    Frontiers in Physiology Reviewing Editor

• 2023.04

  -

  Now

    医学系CBT実施管理委員

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Social Activities 【 display / non-display 】

Social Activities 【 display / non-display 】

• 医学部へようこそ！ ～未知なる宇宙であるヒトの身体を知る学問～

  立命館慶祥中学校  キャリア講演会 

  2023.07

  　

  　

• ゲストティーチャー（お医者さんと研究者のお仕事）

  札幌市立円山小学校 

  2023.02

  　

  　

• 糖尿病重症化予防プロジェクト

  江差保健所 

  2013.09

  　

  　

• 高校生メディカル講座（北海道室蘭栄高等学校）

  北海道教育委員会 

  2012.10

  　

  　

• 高校生メディカル講座（北海道札幌北高等学校）

  札幌医科大学 

  2012.01

  　

  　

Academic Activities 【 display / non-display 】

Academic Activities 【 display / non-display 】

• 第24回日本内分泌学会北海道支部学術集会

  Academic society, research group, etc.

  会長 古橋 眞人  

  2024.10

  　

  　

• 第57回日本糖尿病学会北海道地方会

  Academic society, research group, etc.

  会長 古橋 眞人  

  2023.10

  　

  　

• 第100回北海道医学大会生理系分科会

  Academic society, research group, etc.

  会長 當瀬 規嗣  

  2020.08