Updated on 2025/08/22

写真a

 
TSUKAHARA Tomohide
 
Organization
School of Medicine Department of Pathology (1) Associate Professor
Title
Associate Professor
External link

Research Interests

  • 骨肉腫抗原

  • HLA/ペプチド複合体

  • 軟部腫瘍学

  • ファージディスプレイライブラリ

Research Areas

  • Life Science / Orthopedics

Research History

  • Sapporo Medical University   School of Medicine   Assistant Professor

    2013

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Papers

  • Heat shock protein 90 targets a chaperoned peptide to the static early endosome for efficient cross-presentation by human dendritic cells Reviewed

    Tsutomu Tanaka, Koichi Okuya, Goro Kutomi, Akari Takaya, Toshimitsu Kajiwara, Takayuki Kanaseki, Tomohide Tsukahara, Yoshihiko Hirohashi, Toshihiko Torigoe, Koichi Hirata, Yoshiharu Okamoto, Noriyuki Sato, Yasuaki Tamura

    CANCER SCIENCE   106 ( 1 )   18 - 24   2015.1

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    DOI: 10.1111/cas.12570

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  • A Novel CIC-FOXO4 Gene Fusion in Undifferentiated Small Round Cell Sarcoma A Genetically Distinct Variant of Ewing-like Sarcoma Reviewed

    Shintaro Sugita, Yasuhito Arai, Akiko Tonooka, Natsuko Hama, Yasushi Totoki, Tomoki Fujii, Tomoyuki Aoyama, Hiroko Asanuma, Tomohide Tsukahara, Mitsunori Kaya, Tatsuhiro Shibata, Tadashi Hasegawa

    AMERICAN JOURNAL OF SURGICAL PATHOLOGY   38 ( 11 )   1571 - 1576   2014.11

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    DOI: 10.1097/PAS.0000000000000286

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  • Specific Targeting of a Naturally Presented Osteosarcoma Antigen, Papillomavirus Binding Factor Peptide, Using an Artificial Monoclonal Antibody Reviewed

    Tomohide Tsukahara, Makoto Emori, Kenji Murata, Takahisa Hirano, Norihiro Muroi, Masanori Kyono, Shingo Toji, Kazue Watanabe, Toshihiko Torigoe, Vitaly Kochin, Hiroko Asanuma, Hiroshi Matsumiya, Keiji Yamashita, Tetsuo Himi, Shingo Ichimiya, Takuro Wada, Toshihiko Yamashita, Tadashi Hasegawa, Noriyuki Sato

    JOURNAL OF BIOLOGICAL CHEMISTRY   289 ( 32 )   22035 - 22047   2014.8

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    DOI: 10.1074/jbc.M114.568725

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  • Diagnostic utility of NCOA2 fluorescence in situ hybridization and Stat6 immunohistochemistry staining for soft tissue angiofibroma and morphologically similar fibrovascular tumors Reviewed

    Shintaro Sugita, Tomoyuki Aoyama, Kei Kondo, Yoshiko Keira, Jiro Ogino, Katsuya Nakanishi, Mitsunori Kayo, Makoto Emori, Tomohide Tsukahara, Hisaya Nakajima, Masayuki Takagi, Tadashi Hasegawa

    HUMAN PATHOLOGY   45 ( 8 )   1588 - 1596   2014.8

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    DOI: 10.1016/j.humpath.2013.12.022

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  • The path to innovative drug development of cancer vaccine: From discovery of tumor antigens to clinical trials Reviewed

    Toshihiko Torigoe, Yoshihiko Hirohashi, Tomohide Tsukahara, Takayuki Kanaseki, Vitaly Kochin, Noriyuki Sato

    Japanese Journal of Clinical Immunology   37 ( 2 )   90 - 95   2014

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    DOI: 10.2177/jsci.37.90

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  • Heat shock protein DNAJB8 is a novel target for immunotherapy of colon cancer-initiating cells Reviewed

    Rena Morita, Satoshi Nishizawa, Toshihiko Torigoe, Akari Takahashi, Yasuaki Tamura, Tomohide Tsukahara, Takayuki Kanaseki, Alice Sokolovskaya, Vitaly Kochin, Toru Kondo, Satoshi Hashino, Masahiro Asaka, Isao Hara, Yoshihiko Hirohashi, Noriyuki Sato

    Cancer Science   105 ( 4 )   389 - 395   2014

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    DOI: 10.1111/cas.12362

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  • High expression of CD109 antigen regulates the phenotype of cancer stem-like cells/cancer-initiating cells in the novel epithelioid sarcoma cell line ESX and is related to poor prognosis of soft tissue sarcoma Reviewed

    Makoto Emori, Tomohide Tsukahara, Masaki Murase, Masanobu Kano, Kenji Murata, Akari Takahashi, Terufumi Kubo, Hiroko Asanuma, Kazuyo Yasuda, Vitaly Kochin, Mitsunori Kaya, Satoshi Nagoya, Jun Nishio, Hiroshi Iwasaki, Tomoko Sonoda, Tadashi Hasegawa, Toshihiko Torigoe, Takuro Wada, Toshihiko Yamashita, Noriyuki Sato

    PLoS ONE   8 ( 12 )   e84187   2013.12

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    DOI: 10.1371/journal.pone.0084187

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  • Ectopically Expressed Variant Form of Sperm Mitochondria-Associated Cysteine-Rich Protein Augments Tumorigenicity of the Stem Cell Population of Lung Adenocarcinoma Cells Reviewed

    Akari Takahashi, Yoshihiko Hirohashi, Toshihiko Torigoe, Yasuaki Tamura, Tomohide Tsukahara, Takayuki Kanaseki, Vitaly Kochin, Hiroshi Saijo, Terufumi Kubo, Munehide Nakatsugawa, Hiroko Asanuma, Tadashi Hasegawa, Toru Kondo, Noriyuki Sato

    PLOS ONE   8 ( 11 )   e69095   2013.11

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    DOI: 10.1371/journal.pone.0069095

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  • Small proline-rich protein-1B is overexpressed in human oral squamous cell cancer stem-like cells and is related to their growth through activation of MAP kinase signal Reviewed

    Yoshitaka Michifuri, Yoshihiko Hirohashi, Toshihiko Torigoe, Akihiro Miyazaki, Jyunki Fujino, Yasuaki Tamura, Tomohide Tsukahara, Takayuki Kanaseki, Junichi Kobayashi, Takanori Sasaki, Akari Takahashi, Kenji Nakamori, Akira Yamaguchi, Hiroyoshi Hiratsuka, Noriyuki Sato

    BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS   439 ( 1 )   96 - 102   2013.9

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    DOI: 10.1016/j.bbrc.2013.08.021

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  • Immunotherapeutic benefit of alpha-interferon (IFN alpha) in survivin2B-derived peptide vaccination for advanced pancreatic cancer patients Reviewed

    Hidekazu Kameshima, Tetsuhiro Tsuruma, Goro Kutomi, Hiroaki Shima, Yuji Iwayama, Yasutoshi Kimura, Masahumi Imamura, Toshihiko Torigoe, Akari Takahashi, Yoshihiko Hirohashi, Yasuaki Tamura, Tomohide Tsukahara, Takayuki Kanaseki, Noriyuki Sato, Koichi Hirata

    CANCER SCIENCE   104 ( 1 )   124 - 129   2013.1

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    DOI: 10.1111/cas.12046

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  • Heat shock enhances the expression of cytotoxic granule proteins and augments the activities of tumor-associated antigen-specific cytotoxic T lymphocytes Reviewed

    Akari Takahashi, Toshihiko Torigoe, Yasuaki Tamura, Takayuki Kanaseki, Tomohide Tsukahara, Yasushi Sasaki, Hidekazu Kameshima, Tetsuhiro Tsuruma, Koichi Hirata, Takashi Tokino, Yoshihiko Hirohashi, Noriyuki Sato

    CELL STRESS & CHAPERONES   17 ( 6 )   757 - 763   2012.11

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    DOI: 10.1007/s12192-012-0348-0

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  • SYT-SSX breakpoint peptide vaccines in patients with synovial sarcoma: A study from the Japanese Musculoskeletal Oncology Group Reviewed

    Satoshi Kawaguchi, Tomohide Tsukahara, Kazunori Ida, Shigeharu Kimura, Masaki Murase, Masanobu Kano, Makoto Emori, Satoshi Nagoya, Mitsunori Kaya, Toshihiko Torigoe, Emiri Ueda, Akari Takahashi, Takeshi Ishii, Shin-ichiro Tatezaki, Junya Toguchida, Hiroyuki Tsuchiya, Toshihisa Osanai, Takashi Sugita, Hideshi Sugiura, Makoto Ieguchi, Koichiro Ihara, Ken-ichiro Hamada, Hiroshi Kakizaki, Takeshi Morii, Taketoshi Yasuda, Taisuke Tanizawa, Akira Ogose, Hiroo Yabe, Toshihiko Yamashita, Noriyuki Sato, Takuro Wada

    CANCER SCIENCE   103 ( 9 )   1625 - 1630   2012.9

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    DOI: 10.1111/j.1349-7006.2012.02370.x

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  • NK/T-cell lymphoma of bilateral adrenal glands in a patient with pyothorax Reviewed

    Tomohide Tsukahara, Akira Takasawa, Masaki Murata, Kazuyoshi Okumura, Masato Nakayama, Noriyuki Sato, Tadashi Hasegawa

    DIAGNOSTIC PATHOLOGY   7   114   2012.8

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    DOI: 10.1186/1746-1596-7-114

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  • ECRG4 is a negative regulator of caspase-8-mediated apoptosis in human T-leukemia cells Reviewed

    Junichi Matsuzaki, Toshihiko Torigoe, Yoshihiko Hirohashi, Kenjiro Kamiguchi, Yasuaki Tamura, Tomohide Tsukahara, Terufumi Kubo, Akari Takahashi, Emiri Nakazawa, Eri Saka, Kazuyo Yasuda, Shuji Takahashi, Noriyuki Sato

    CARCINOGENESIS   33 ( 5 )   996 - 1003   2012.5

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    DOI: 10.1093/carcin/bgs118

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  • [Peptide vaccination therapy for bone and soft tissue sarcoma]. Reviewed

    Emori M, Tsukahara T, Kawaguchi S, Wada T

    Nihon rinsho. Japanese journal of clinical medicine   69 ( 9 )   1670 - 1673   2011.9

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    Other Link: http://search.jamas.or.jp/link/ui/2011345370

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  • Autologous CTL response against cancer stem-like cells/cancer-initiating cells of bone malignant fibrous histiocytoma Reviewed

    Masanobu Kano, Tomohide Tsukahara, Makoto Emori, Masaki Murase, Toshihiko Torigoe, Satoshi Kawaguchi, Takuro Wada, Toshihiko Yamashita, Noriyuki Sato

    CANCER SCIENCE   102 ( 8 )   1443 - 1447   2011.8

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    DOI: 10.1111/j.1349-7006.2011.01962.x

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  • Immunogenic enhancement and clinical effect by type-I interferon of anti-apoptotic protein, survivin-derived peptide vaccine, in advanced colorectal cancer patients Reviewed

    Hidekazu Kameshima, Tetsuhiro Tsuruma, Toshihiko Torigoe, Akari Takahashi, Yoshihiko Hirohashi, Yasuaki Tamura, Tomohide Tsukahara, Shingo Ichimiya, Takayuki Kanaseki, Yuji Iwayama, Noriyuki Sato, Koichi Hirata

    CANCER SCIENCE   102 ( 6 )   1181 - 1187   2011.6

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    DOI: 10.1111/j.1349-7006.2011.01918.x

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  • Prognostic Significance of HLA Class I Expression in Ewing's Sarcoma Family of Tumors Reviewed

    Hiroki Yabe, Tomohide Tsukahara, Satoshi Kawaguchi, Takuro Wada, Toshihiko Torigoe, Noriyuki Sato, Chihiro Terai, Masaya Aoki, Shigemichi Hirose, Hideo Morioka, Hiroo Yabe

    JOURNAL OF SURGICAL ONCOLOGY   103 ( 5 )   380 - 385   2011.4

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    DOI: 10.1002/jso.21829

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  • HLA-A*0201-restricted CTL epitope of a novel osteosarcoma antigen, papillomavirus binding factor Reviewed

    Tomohide Tsukahara, Satoshi Kawaguchi, Toshihiko Torigoe, Akari Takahashi, Masaki Murase, Masanobu Kano, Takuro Wada, Mitsunori Kaya, Satoshi Nagoya, Toshihiko Yamashita, Noriyuki Sato

    JOURNAL OF TRANSLATIONAL MEDICINE   7   44   2009.6

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    DOI: 10.1186/1479-5876-7-44

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  • Molecular pathological approaches to human tumor immunology Reviewed

    Noriyuki Sato, Yoshihiko Hirohashi, Tomohide Tsukahara, Tomoki Kikuchi, Hiroeki Sahara, Kenjiro Kamiguchi, Shingo Ichimiya, Yasuaki Tamura, Toshihiko Torigoe

    PATHOLOGY INTERNATIONAL   59 ( 4 )   205 - 217   2009.4

  • Scythe/BAT3 regulates apoptotic cell death induced by papillomavirus binding factor in human osteosarcoma Reviewed

    Tomohide Tsukahara, Shigeharu Kimura, Shingo Ichimiya, Toshihiko Torigoe, Satoshi Kawaguchi, Takuro Wada, Toshihiko Yamashita, Noriyuki Sato

    CANCER SCIENCE   100 ( 1 )   47 - 53   2009.1

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    DOI: 10.1111/j.1349-7006.2008.00991.x

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  • Clonal T-Cell response against autologous pleomorphic malignant fibrous histiocytoma antigen presented by retrieved HLA-A*0206 Reviewed

    Shigeharu Kimura, Yuriko Kozakai, Satoshi Kawaguchi, Tomohide Tsukahara, Kazunori Ida, Masaki Murase, Tadaki Matsumura, Mitunori Kaya, Toshihiko Torigoe, Takuro Wada, Noriyuki Sato, Toshihiko Yamashita

    JOURNAL OF ORTHOPAEDIC RESEARCH   26 ( 2 )   271 - 278   2008.2

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    DOI: 10.1002/jor.20497

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  • Prognostic impact and immunogenicity of a novel osteosarcoma antigen, papillomavirus binding factor, in patients with osteosarcoma Reviewed

    Tomohide Tsukahara, Satoshi Kawaguchi, Toshihiko Torigoe, Shigeharu Kimura, Masaki Murase, Shingo Ichimiya, Takuro Wada, Mitsunori Kaya, Satoshi Nagoya, Takeshi Ishii, Shin-ichiro Tatezaki, Toshihiko Yamashita, Noriyuki Sato

    CANCER SCIENCE   99 ( 2 )   368 - 375   2008.2

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    DOI: 10.1111/j.1349-7006.2008.00695.x

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  • Overexpression of papillomavirus binding factor in Ewing's sarcoma family of tumors conferring poor prognosis Reviewed

    Hiroki Yabe, Tomohide Tsukahara, Satoshi Kawaguchi, Takuro Wada, Noriyuki Sato, Hideo Morioka, Hiroo Yabe

    ONCOLOGY REPORTS   19 ( 1 )   129 - 134   2008.1

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  • Identification of CLUAP1 as a human osteosarcoma tumor-associated antigen recognized by the humoral immune system Reviewed

    Hisamitsu Ishikura, Hiroaki Ikeda, Hiroyuki Abe, Takayuki Ohkuri, Hiroaki Hiraga, Kazuo Isu, Tomohide Tsukahara, Noriyuki Sato, Hidemitsu Kitamura, Norimasa Iwasaki, Naoki Takeda, Akio Minami, Takashi Nishimura

    INTERNATIONAL JOURNAL OF ONCOLOGY   30 ( 2 )   461 - 467   2007.2

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  • Prognostic significance of HLA class I expression in osteosarcoma defined by anti-pan HLA class I monoclonal antibody, EMR8-5 Reviewed

    Tomohide Tsukahara, Satoshi Kawaguchi, Toshihiko Torigoe, Hiroko Asanuma, Emiri Nakazawa, Kumiko Shimozawa, Yuki Nabeta, Shigeharu Kimura, Mitsunori Kaya, Satoshi Nagoya, Takuro Wada, Toshihiko Yamashita, Noriyuki Sato

    CANCER SCIENCE   97 ( 12 )   1374 - 1380   2006.12

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    DOI: 10.1111/j.1349-7006.2006.00317.x

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  • HLA-restricted specific tumor cytolysis by autologous T-lymphocytes infiltrating metastatic bone malignant fibrous histiocytoma of lymph node Reviewed

    T Tsukahara, S Kawaguchi, K Ida, S Kimura, Y Tamura, T Ikeda, T Torigoe, S Nagoya, T Wada, N Sato, TS Yamashita

    JOURNAL OF ORTHOPAEDIC RESEARCH   24 ( 1 )   94 - 101   2006.1

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    DOI: 10.1002/jor.20019

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  • A quest for therapeutic antigens in bone and soft tissue sarcoma Reviewed

    S Kawaguchi, T Wada, T Tsukahara, K Ida, T Torigoe, N Sato, T Yamashita

    JOURNAL OF TRANSLATIONAL MEDICINE   3   31   2005.8

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  • Aberrant expression and potency as a cancer immunotherapy target of inhibitor of apoptosis protein family, Livin/ML-IAP in lung cancer Reviewed

    H Hariu, Y Hirohashi, T Torigoe, H Asanuma, M Hariu, Y Tamura, K Aketa, C Nabeta, K Nakanishi, K Kamiguchi, Y Mano, H Kitamura, J Kobayashi, T Tsukahara, N Shijubo, N Sato

    CLINICAL CANCER RESEARCH   11 ( 3 )   1000 - 1009   2005.2

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  • Phase I vaccination trial of SYT-SSX junction peptide in patients with disseminated synovial sarcoma Reviewed

    S Kawaguchi, T Wada, K Ida, Y Sato, S Nagoya, T Tsukahara, S Kimura, H Sahara, H Ikeda, K Shimozawa, H Asanuma, T Torigoe, H Hiraga, T Ishii, S Tatezaki, N Sato, T Yamashita

    JOURNAL OF TRANSLATIONAL MEDICINE   3   1 - 9   2005.1

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    DOI: 10.1186/1479-5876-3-1

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  • Identification of human autologous cytotoxic T-lymphocyte-defined osteosarcoma gene that encodes a transcriptional regulator, papillomavirus binding factor Reviewed

    T Tsukahara, Y Nabeta, S Kawaguchi, H Ikeda, Y Sato, K Shimozawa, K Ida, H Asanuma, Y Hirohashi, T Torigoe, H Hiraga, S Nagoya, T Wada, T Yamashita, N Sato

    CANCER RESEARCH   64 ( 15 )   5442 - 5448   2004.8

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    DOI: 10.1158/0008-5472.CAN-04-0522

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  • Crisscross CTL induction by SYT-SSX junction peptide and its HLA-A*2402 anchor substitute Reviewed

    K Ida, S Kawaguchi, Y Sato, T Tsukahara, Y Nabeta, H Sahara, H Ikeda, T Torigoe, S Ichimiya, K Kamiguchi, T Wada, S Nagoya, H Hiraga, A Kawai, T Ishii, N Araki, A Myoui, S Matsumoto, T Ozaki, H Yoshikawa, T Yamashita, N Sato

    JOURNAL OF IMMUNOLOGY   173 ( 2 )   1436 - 1443   2004.7

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    DOI: 10.4049/jimmunol.173.2.1436

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  • Simultaneous radial closing wedge and ulnar shortening osteotomies for distal radius malunion Reviewed

    T Wada, S Isogai, K Kanaya, T Tsukahara, T Yamashita

    JOURNAL OF HAND SURGERY-AMERICAN VOLUME   29A ( 2 )   264 - 272   2004.3

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    DOI: 10.1016/j.jhsa.2003.12.001

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  • Recognition by cellular and humoral autologous immunity in a human osteosarcoma cell line Reviewed

    Yuki Nabeta, Satoshi Kawaguchi, Hiroeki Sahara, Hideyuki Ikeda, Yoshihiko Hirohashi, Takahiro Goroku, Yuriko Sato, Tomohide Tsukahara, Toshihiko Torigoe, Takuro Wada, Mitsunori Kaya, Hiroaki Hiraga, Kazuo Isu, Shinya Yamawaki, Seiichi Ishii, Toshihiko Yamashita, Noriyuki Sato

    Journal of Orthopaedic Science   8 ( 4 )   554 - 559   2003

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    Language:English   Publishing type:Research paper (scientific journal)   Publisher:Springer Japan  

    DOI: 10.1007/s00776-003-0663-5

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  • Improved generation of HLA class I/peptide tetramers Reviewed

    Y Sato, H Sahara, T Tsukahara, M Kondo, Y Hirohashi, Y Nabeta, S Kawaguchi, H Ikeda, T Torigoe, S Ichimiya, Y Tamura, T Wada, T Yamashita, M Goto, H Takasu, N Sato

    JOURNAL OF IMMUNOLOGICAL METHODS   271 ( 1-2 )   177 - 184   2002.12

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    DOI: 10.1016/S0022-1759(02)00329-0

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  • Detection and induction of CTLs specific for SYT-SSX-derived peptides in HLA-A24(+) patients with synovial sarcoma Reviewed

    Y Sato, Y Nabeta, T Tsukahara, Y Hirohashi, R Syunsui, A Maeda, H Sahara, H Ikeda, T Torigoe, S Ichimiya, T Wada, T Yamashita, H Hiraga, A Kawai, T Ishii, N Araki, A Myoui, S Matsumoto, T Umeda, S Ishii, S Kawaguchi, N Sato

    JOURNAL OF IMMUNOLOGY   169 ( 3 )   1611 - 1618   2002.8

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    DOI: 10.4049/jimmunol.169.3.1611

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MISC

  • ビギナーズセミナー7 わかる!がん免疫とがん抗原

    塚原 智英

    日本臨床免疫学会会誌   37 ( 4 )   299 - 299   2014

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    癌免疫は,癌に対する免疫応答の理解と癌の免疫制御を目指す学問であり,癌抗原の同定によって飛躍的に発展した.よって癌免疫の理解には癌抗原の理解が重要である.癌免疫の存在は1990年代に自家細胞傷害性T細胞(CTL)クローンに認識されるヒト癌抗原のクローニングにより,主にメラノーマで証明された.これらの発見にはforward immunology approachといわれる腫瘍反応性ヒト自家CTLクローンの樹立とcDNAライブラリ発現クローニング法の開発が大きく貢献した.さらに既知の候補抗原からCTLエピトープを求めるreverse immunology approachも盛んに行われ,メラノーマ以外からも多くの抗原が同定された.これらの知見はペプチドワクチンや抗原特異的リンパ球大量輸注療法の開発につながっている.また昨年は抗CTLA-4抗体や抗PD-1抗体などのチェックポイント抗体による活性化T細胞制御がメラノーマに対して有効性を示して一世を風靡した.チェックポイント抗体がメラノーマでよく効いた理由として(1)癌抗原が皮膚のランゲルハンス細胞に取り込まれてCTLを効率よくプライムできる,(2)高い免疫原性を持つ変異抗原が多く発現してる点が重要と考えられる.今後は高い腫瘍特異性をもち,かつ造腫瘍能を制御する癌の根源に迫る癌抗原の同定が重要となる.また自家CTLが認識する抗原の同定は,時に我々の想像がおよばないようなセレンディピティを与えてくれる.

    DOI: 10.2177/jsci.37.299

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  • 合同シンポジウム2-5  がんワクチン創薬への道程:がん抗原の同定から臨床試験まで

    鳥越 俊彦, 廣橋 良彦, 塚原 智英, 島 宏彰, 水口 徹, 平田 公一, 佐藤 昇志

    日本臨床免疫学会会誌   36 ( 5 )   313 - 313   2013

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    Language:Japanese   Publisher:日本臨床免疫学会  

    我々は過去20年以上にわたってヒトがん抗原の同定とそれに対する免疫応答の分子機構を解明し,Survivinをはじめとする10種類以上のヒトがん抗原とそのHLA class I拘束性T細胞エピトープの構造を明らかにしてきた.抗原ペプチドを用いて患者の末梢血リンパ球を刺激すると,ペプチド特異的細胞障害性T細胞が誘導される.平成14年度からSVN-2Bペプチドワクチンの臨床試験を開始.平成23年度からは医師主導治験を実施している.Tetramerを用いた免疫モニタリングの結果,ペプチド特異的T細胞の頻度と抗腫瘍効果との間に相関性が見出された.また,インターフェロンの併用によって臨床効果が増強することが判明した.10月には進行膵臓がんに対する第2相試験(二重盲検試験)をスタートする.  一方で我々は,ヒトの固形腫瘍細胞株からがん幹細胞(CSC)を分離することに成功し,現在CSC特異抗原の探索を実施している.がん幹細胞は,長寿命・高い造腫瘍能力・高い遊走能・抗がん剤耐性などの特性を有することから,がん再発と転移の根幹をなす細胞であると推察されている.CSC特異抗原はどのような分子か,CSC特異的細胞障害性T細胞の誘導とCSC標的治療モデル等を紹介し,がん幹細胞標的ワクチン創薬に向けての歩みと展望についても議論したい.

    DOI: 10.2177/jsci.36.313

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  • 肩関節 antero-superior corner 損傷による前(上)方不安定症の1例

    福島 直, 岡村 健司, 木村 明彦, 塚原 智英

    関節鏡 = ARTHROSCOPY Society magazine guidance & Contribution rules   22 ( 3 )   1997.11

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