Research Areas 【 display / non-display 】

Research Areas 【 display / non-display 】

• Life sciences   Dermatology  

Affiliation 【 display / non-display 】

Affiliation 【 display / non-display 】

• Sapporo Medical University   医学部   助教  

Papers 【 display / non-display 】

Papers 【 display / non-display 】

• Anogenital skin necrosis with fibrin thrombosis induced by crotamiton.

  Toshiya Handa, Takafumi Kamiya, Yuji Kan, Tokimasa Hida, Yasuyuki Sumikawa, Tomoyuki Minowa, Hisashi Uhara

  Contact dermatitis   86 ( 3 ) 221 - 223  2022.03  [International journal]

  DOI PubMed

• Case of pneumatosis cystoides intestinalis with pemphigus vulgaris.

  Eri Kobayashi, Yuji Kan, Takafumi Kamiya, Ayako Kumagai, Hisashi Uhara

  The Journal of dermatology   47 ( 11 ) e412-e413  2020.11  [International journal]

  DOI PubMed

• Cold urticaria comorbid with heat urticaria: A case report.

  Takahiro Ohashi, Yuji Kan, Hiroyuki Takahashi, Daisuke Yoneta, Kimi Kase, Yasuyuki Sumikawa, Hisashi Uhara

  The Journal of dermatology   47 ( 9 ) e325-e326  2020.09  [International journal]

  DOI PubMed

• Regular sweating activities for the treatment of cholinergic urticaria with or without acquired idiopathic generalized anhidrosis.

  Tomoyuki Minowa, Yasuyuki Sumikawa, Yuji Kan, Takafumi Kamiya, Hisashi Uhara

  Dermatologic therapy   33 ( 4 ) e13647  2020.07  [International journal]

  　View Summary

  Cholinergic urticaria (CholU) decreases affected individuals' quality of life because they must avoid stimuli including exercise and hot bathing. Although case reports have indicated that regular sweating activities are effective for CholU with hypohidrosis, little evidence is available. This retrospective medical record review examined CholU patients who received any form of treatment at our hospital. Twenty-seven cases (78% men; median age 22 years, range 12-70 years) were analyzed. Fourteen (52%) patients had acquired idiopathic generalized anhidrosis (AIGA). Among the 12 patients receiving sweating therapy (4 with, 8 without AIGA), improvement of symptoms was confirmed in 11 (92%; sweating therapy alone: n = 5, with H1 blocker: n = 5, with steroid pulse: n = 1) including 8 (67%) showing complete response (CR). In this sweating-therapy group, CR was achieved by six of the eight (75%) patients without AIGA and two of the four (50%) patients with AIGA. Among the 15 patients without sweating therapy, symptom improvement was observed in 9 (60%; steroid pulse: n = 7, H1 blocker: n = 2) including 1 (7%) achieving CR. Sweating therapy was safely undertaken except in one case in which the patient showed angioedema and anaphylaxis. Regular sweating activities could be a potential therapeutic option for CholU patients.

  DOI PubMed

• コリン性蕁麻疹における定期的な発汗刺激の有効性に関する後方視的検討

  箕輪 智幸, 澄川 靖之, 菅 裕司, 神谷 崇文, 宇原 久

  日本皮膚科学会雑誌 ( (公社)日本皮膚科学会 )  130 ( 5 ) 1217 - 1217  2020.05

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Misc 【 display / non-display 】

Misc 【 display / non-display 】

• コリン性蕁麻疹における定期的な発汗刺激の有効性に関する後方視的検討

  箕輪 智幸, 澄川 靖之, 菅 裕司, 神谷 崇文, 宇原 久

  日本皮膚科学会雑誌 ( (公社)日本皮膚科学会 )  130 ( 5 ) 1217 - 1217  2020.05

• 中毒疹様皮疹を契機に診断に至った全身性エリテマトーデス(SLE)の1例

  西田 彩華, 小林 英理, 細川 夕菜, 箕輪 智幸, 熊谷 綾子, 菅 裕司, 神谷 崇文, 宇原 久

  日本皮膚科学会雑誌 ( (公社)日本皮膚科学会 )  130 ( 1 ) 39 - 39  2020.01

• 発汗指導を行ったコリン性蕁麻疹12症例の検討

  箕輪 智幸, 澄川 靖之, 菅 裕司, 兼古 理恵, 宇原 久

  日本皮膚科学会雑誌 ( (公社)日本皮膚科学会 )  130 ( 1 ) 80 - 80  2020.01

• 自己免疫性水疱症例における免疫グロブリン大量療法後の血小板減少についての検討

  小林 英理, 菅 裕司, 細川 夕菜, 箕輪 智幸, 米田 大介, 熊谷 綾子, 神谷 崇文, 澄川 靖之, 宇原 久

  日本皮膚科学会雑誌 ( (公社)日本皮膚科学会 )  129 ( 11 ) 2335 - 2335  2019.10

• 尋常性天疱瘡の治療中に腸管気腫症をきたした1例

  小林 英理, 菅 裕司, 半田 稔也, 松井 馨之, 細川 夕菜, 箕輪 智幸, 熊谷 綾子, 神谷 崇文, 澄川 靖之, 宇原 久

  日本皮膚科学会雑誌 ( (公社)日本皮膚科学会 )  129 ( 9 ) 1909 - 1909  2019.08

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Research Projects 【 display / non-display 】

Research Projects 【 display / non-display 】

• Expression of skin barrier protein cystatin A analysis in the AD patients skin

  Grant-in-Aid for Young Scientists (B)

  Project Year :

  2014.04

  -

  2017.03

   

  KAN YUJI, YAMASHITA Toshiharu, SUMIKAWA Yasuyuki, YOKOTA Shinichi

  　View Summary

  Cystatin A is present in skin and known as protein with the antiviral effect. After immunostaining cystatin A of the atopic dermatitis (AD) patients skin of 30 cases, we compared AD lesion and normal AD skin with healthy part. Both cystatin of AD skin lesion and the healthy part was found to have attenuated as compared with normal skin in expression of cystatin A. After transmitting a herpesvirus 1、2 and adenoviral type 5 to HaCaT cells, cystatin A inhibited these viral DNA and protein synthesis. It was thought to become easy to develop for herpesvirus infection including the Kaposi varicelliform eruption as a result of decrease of barrier function. Cystatin A can become the new therapy for these infections in the future.