Education 【 display / non-display 】

Education 【 display / non-display 】

• 1989

  -

  1993

  九州大学大学院   医学研究科   分子薬理学  

• 1979

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  1985

  Kyushu University   School of Medicine   医学  

• 　

  -

  1993

  Kyushu University   Graduate School, Division of Medicine   Molecular Pharmacology  

• 　

  -

  1985

  Kyushu University   Faculty of Medicine  

Research Experience 【 display / non-display 】

Research Experience 【 display / non-display 】

• 2011

  -

  Now

  Sapporo Medical University   School of Medicine   教授

  教授

• 2006

  -

  2011

  Kyushu University  

• 2001

  -

  2006

  Kyushu University  

• 2001

  　

  　

  - Lecturer, Kyushu University  

• 1995

  -

  2001

  Research Associate, Kyushu University  

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Professional Memberships 【 display / non-display 】

Professional Memberships 【 display / non-display 】

• 　

  　

  　

  ARRS

• 　

  　

  　

  日本放射線腫瘍学会

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  ASTRO

Research Areas 【 display / non-display 】

Research Areas 【 display / non-display 】

• Life sciences   Radiology  

Research Interests 【 display / non-display 】

Research Interests 【 display / non-display 】

• Radiology

• テンソル

• 緩和時間

• MRI

• 拡散

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Papers 【 display / non-display 】

Papers 【 display / non-display 】

• Diagnosis of prosthetic joint infection at the hip using the standard uptake value of three-phase 99mTc-hydroxymethylene diphosphonate SPECT/CT

  Naoya Yama, Satoshi Nagoya, Shintaro Sugita, Masayuki Koyama, Masamitsu Hatakenaka

  Annals of Nuclear Medicine ( Springer Science and Business Media LLC )   2022.04

  DOI

• DWI-related texture analysis for prostate cancer: differences in correlation with histological aggressiveness and data repeatability between peripheral and transition zones

  Chie Tsuruta, Kenji Hirata, Kohsuke Kudo, Naoya Masumori, Masamitsu Hatakenaka

  European Radiology Experimental ( Springer Science and Business Media LLC )  6 ( 1 )  2022.03

  DOI

• Abnormal [18F]fluorodeoxyglucose accumulation to tori tubarius in IgG4-related disease

  Ken Nagahata, Masatoshi Kanda, Ryuta Kamekura, Masanari Sugawara, Naoya Yama, Chisako Suzuki, Kenichi Takano, Masamitsu Hatakenaka, Hiroki Takahashi

  Annals of Nuclear Medicine ( Springer Science and Business Media LLC )  36 ( 2 ) 200 - 207  2022.02  [Domestic journal]

  　View Summary

  OBJECTIVES: Tubarial glands (TGs) are recently refocused gland tissues localized near the tori tubarius in the nasopharynx and their clinical relevance is not clear yet. IgG4-related disease (IgG4-RD) is a progressive fibrosing condition and salivary glands are well-affected lesions. The aim of the present study is to examine [18F]fluorodeoxyglucose ([18F]FDG) accumulation to the tori tubarius in IgG4-related disease (IgG4-RD). METHODS: 48 patients with IgG4-RD who underwent positron emission tomography (PET) scanning with [18F]FDG were included and semi-quantitative analysis of [18F]FDG accumulation to tori tubarius was performed along with the clinical features and histopathological analysis. RESULTS: Of the 48 patients, abnormal [18F]FDG accumulation (metabolic tumour volume ≥ 1) to tori tubarius was observed in 15 (31.3%), all of whom had lesions in other head and neck glands. IgG4-RD patients with abnormal [18F]FDG accumulation to tori tubarius showed swollen nasopharyngeal walls around tori tubarius and forceps biopsy of the lesion revealed acinar cells and IgG4-positive plasma cells histologically. Abnormal [18F]FDG accumulation (maximum standard uptake value, metabolic tumour volume and total lesion glycolysis) to tori tubarius correlated with higher IgG4 and lower IgA serum concentrations. CONCLUSIONS: Abnormal [18F]FDG accumulation to tori tubarius can be observed in patients with IgG4-RD and the abnormal [18F]FDG accumulation to tori tubarius can be a clue of TG involvement in IgG4-RD.

  DOI PubMed

• MRI-detected extramural vascular invasion potentiates the risk for pathological metastasis to the lateral lymph nodes in rectal cancer.

  Atsushi Hamabe, Masayuki Ishii, Koichi Onodera, Kenji Okita, Toshihiko Nishidate, Koichi Okuya, Emi Akizuki, Ryo Miura, Takahiro Korai, Masamitsu Hatakenaka, Ichiro Takemasa

  Surgery today    2021.03  [Domestic journal]

  　View Summary

  PURPOSE: Multidisciplinary treatment for locally advanced rectal cancer requires an accurate assessment of the risk of metastasis to the lateral lymph nodes (LNs). We herein aimed to stratify the risk of pathological metastasis to lateral LNs based on the preoperatively detected malignant features. METHODS: All patients with rectal cancer who underwent surgery from January 2016 to July 2020 were identified. We recorded the TNM factors; perirectal and lateral LN sizes; and MRI findings, including mesorectal fascia involvement, extramural vascular invasion (EMVI), tumor site, and tumor distance from the anal verge. RESULTS: 101 patients underwent rectal resection with lateral lymph node dissection, of whom 16 (15.8%) exhibited pathological metastases to the lateral LNs. Univariate analyses demonstrated that lateral LN metastasis was significantly correlated with mrEMVI positivity (p = 0.0023) and a baseline lateral LN short-axis length of ≥ 5 mm (p < 0.0001). These significant associations were confirmed by a multivariate analysis (p = 0.0254 and 0.0027, respectively). The lateral LN metastasis rate was as high as 44% in cases bearing both risk factors, compared to 0% in cases lacking both risk factors. CONCLUSION: The results elucidated in this study may contribute to risk stratification, which can be used when determining the indications for lateral lymph node dissection.

  DOI PubMed

• CT reconstruction with thick slices not only underestimates lymph node size but also reduces data reproducibility in colorectal cancer.

  Yurina Onuma, Chie Tsuruta, Kenji Okita, Atsushi Hamabe, Keishi Ogura, Ichiro Takemasa, Masamitsu Hatakenaka

  Acta radiologica (Stockholm, Sweden : 1987)     284185120968569 - 284185120968569  2020.10  [International journal]

  　View Summary

  BACKGROUND: Reliable size measurement of lymph node (LN) metastases is important for the evaluation of cancer treatment. However, image analyses without proper settings may result in inappropriate diagnoses and staging. PURPOSE: To investigate whether reconstruction slice thickness in computed tomography (CT) affects measurements of LN size and reproducibility. MATERIAL AND METHODS: We analyzed 48 patients with histological diagnoses of sigmoid colon and rectal cancer who underwent contrast-enhanced CT colonography as part of a surgical treatment preparation. A board-certified radiologist selected 106 LNs whose short-axis diameter was ≥5 mm on 1-mm-thick images; the short-axis diameters were measured on 1- and 5-mm-thick images by the radiologist and residents and compared using Wilcoxon matched-pairs signed rank test. Data variation and reproducibility were evaluated using the F test and Bland-Altman analysis. P<0.05 was considered significant. RESULTS: Short-axis diameters measured on 5-mm-thick images were significantly lower than those measured on 1-mm-thick images (P<0.01), even in the LNs whose short-axis diameters were over twice the slice thickness (P<0.05). Of the 106 LNs, 57 showed short-axis diameter <5 mm on 5-mm-thick images; the maximum short-axis diameter was 6.7 mm on a 1-mm thick image. Data variation was significantly larger on 5-mm thick images than 1-mm-thick images in small LNs (P<0.05) and reproducibility on 5-mm-thick images was inferior to that on 1-mm-thick images. CONCLUSION: Thick reconstruction slices in CT can result in an underestimation of LN size and reduce data reproducibility. When measuring LN size, a thin reconstruction slice would be recommended based on targeted LN size.

  DOI PubMed

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Misc 【 display / non-display 】

Misc 【 display / non-display 】

• SPECT/CTにおけるセンチネルリンパ節集積部位とリンパ節転移についての検討

  島 宏彰, 九冨 五郎, 里見 蕗乃, 高丸 智子, 前田 豪樹, 鈴木 やすよ, 亀嶋 秀和, 大村 東生, 森 満, 畠中 正光, 長谷川 匡, 平田 公一

  日本乳癌学会総会プログラム抄録集 ( (一社)日本乳癌学会 )  22回   464 - 464  2014.07

• 上咽頭癌に対する強度変調放射線治療 当院での治療成績

  北川 未央, 中田 健生, 坂田 耕一, 染谷 正則, 舘岡 邦彦, 堀 正和, 高木 克, 三浦 勝利, 畠中 正光

  Japanese Journal of Radiology ( (公社)日本医学放射線学会 )  32 ( Suppl. ) 5 - 5  2014.02

• Epithelioid Sarcomaの画像

  土屋 高旭, 玉川 光春, 河合 有里子, 荒谷 和紀, 兵藤 秀樹, 山 直也, 庄内 孝春, 佐藤 大志, 小野寺 麻希, 鷲尾 嘉一, 浅井 真友美, 畠中 正光

  Japanese Journal of Radiology ( (公社)日本医学放射線学会 )  32 ( Suppl. ) 3 - 3  2014.02

• 当院における中下咽頭癌IMRTの治療成績

  中田 健生, 北川 未央, 堀 正和, 長谷川 智一, 三浦 勝利, 染谷 正則, 舘岡 邦彦, 坂田 耕一, 畠中 正光

  Japanese Journal of Radiology ( (公社)日本医学放射線学会 )  32 ( Suppl. ) 5 - 5  2014.02

• 当科の食道がんに対する放射線治療成績

  堀 正和, 中田 健生, 染谷 正則, 高木 克, 三浦 勝利, 北川 未央, 長谷川 智一, 坂田 耕一, 畠中 正光

  Japanese Journal of Radiology ( (公社)日本医学放射線学会 )  32 ( Suppl. ) 5 - 5  2014.02

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Awards 【 display / non-display 】

Awards 【 display / non-display 】

• JJR Excellent reviewer award

  2021.04   Japan Radiological Society  

• Silver distinguished reviewer achevement

  2019.03   America Roentgen Ray Society  

• Certificate

  2018   Japan Radiological Society  

  Winner： HATAKENAKA Masamitsu

• Peer Review Certificate

  2017   European Society of Radiology  

  Winner： HATAKENAKA Masamitsu

• Special distinguished Reviewer

  2016.05   ISMRM  

  Winner： HATAKENAKA Masamitsu

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Research Projects 【 display / non-display 】

Research Projects 【 display / non-display 】

• 直腸癌の個別的リスク評価を目的とした人工知能MRI解析アルゴリズムの確立

  基盤研究(B)

  Project Year :

  2022.04

  -

  2025.03

   

  竹政 伊知朗, 渡辺 昌彦, 内藤 剛, 浜部 敦史, 奥谷 浩一, 石井 雅之, 畠中 正光, 森 正樹, 土岐 祐一郎, 江口 英利, 坂井 義治, 肥田 侯矢, 吉野 孝之, 沖 英次

• Evaluation of rectal cancer aggressiveness based on conductivity imaging

  Grant-in-Aid for Scientific Research (C)

  Project Year :

  2018.04

  -

  2022.03

   

  畠中 正光, 山 直也, 小野寺 麻希, 杉田 真太朗, 西舘 敏彦

  　View Summary

  データの再現性に関して懸念があったので、現時点でデータ会で気が可能であるconductivity計算画像8症例のtexture analysisを行い、そのICCおよびその95％confidence interval(95%CI)をIVIM計算画像21例のパラメータ内最も再現性が高いと考えられているD値のICCおよびその95％CIと比較した。 Conductivityのminimum: ICC=0.752, 95%CI=0.219-0.944、25%:ICC=0.844, 95%CI=0.446-0.966, 50%: ICC=0.791, 95%CI=0.308-0.953, mean: ICC=0.745, 95%CI=0.204-0.942, 75%: ICC=0.554, 95%CI=-0.13-0.889, maximum: ICC=0.596, 95%CI=-0.069-0.902, skewness: ICC=-0.061, 95%CI=-0.673-0.625, kurtosis: ICC=0.035, 95%CI=-0.617-0.680に対し、D値のminimum: ICC=0.386, 95% CI=-0.048-0.700, 25%: ICC=0.709, 95%CI=0.405-0.873, 50%: ICC=0.829, 95%CI=0.624-0.928, mean: ICC=0.791, 95%CI=0.551-0.911, 75%: ICC=0.813, 95%CI=0.592-0.921, maximum: ICC=0.787, 95%CI=0.544-0.909, skewness: ICC=0.300, 95%CI=-0.144-0.647, kurtosis: ICC=0.636, 95%CI=0.288-0.837であった。

• Establishment of early detection and treatment assessment of pulmonary hypertension by PC-cine MRI

  Grant-in-Aid for Scientific Research (C)

  Project Year :

  2016.04

  -

  2019.03

   

  Murayamma Sadayuki

  　View Summary

  Phase contrast MRI (PC-MRI) can determine pulmonary hemodynamics noninvasively. Pulmonary hypertension causes changes in pulmonary hemodynamics and is a factor for acute exacerbation and death in interstitial lung diseases (ILD). The purpose of this study was to determine the association between pulmonary hemodynamics measured by PC-MRI and episodes of acute exacerbations and death in patients with ILD related pulmonary hypertension. Reduction in right cardiac output, as detected by PC-MRI, was associated with acute exacerbation and increased mortality in ILD. MR examination to detect right ventricular dysfunction is useful for predicting the poor prognosis in fibrotic ILD patients, even if they are not combined with pulmonary hypertension.

• Predicting treatment effect and prognosis by using IVIM

  Grant-in-Aid for Scientific Research (C)

  Project Year :

  2014

  -

  2016

   

  Hatakenaka Masmaitsu

  Authorship： Principal investigator

  　View Summary

  In total, 28 patients with head and neck cancer who were treated with (chemo)radiotherapy were enrolled in the present study. However, 8 patients were excluded due to poor image quality and/or inadequate clinical data. Further, patients with nasopharyngeal cancer were excluded because its D is lower and sensitive to chemoradiotherapy. Finally, 10 patients were statistically analyzed. The pre-treatment D value for 6 patients without recurrence was 0.640±0.168 mm2/s and that for 4 ones with recurrence was 0.921±0.204 mm2/s and statistically significant difference was observed (p<0.05). The ratio of D value increase at 10Gy was 0.350±0.533 without recurrence and 0.04±0.174 with recurrence but statistical significance was not observed. F(perfusion fraction) and D*(perfusion) derived from IVIM method show wide variation. Signal intensity at b=25 s/mm2 was lower than that at b=50 s/mm2 in some cases. Thus, F and D* were not analyzed.

• MRI of locally advanced esophageal cancer: response evaluation to chemoradiotherapy

  Grant-in-Aid for Scientific Research (C)

  Project Year :

  2011

  -

  2013

   

  KIYOHISA Hiraka, TSURUMARU Daisuke, HONDA Hiroshi, MATSUO Yoshio, MIYASAKA Mitsutoshi, NISHIMUTA Yusuke, SASAKI Tomonari

  　View Summary

  In this study, we studied the image parameters to predict the therapeutic effect of radiotherapy/chemoradiotherapy for esophageal cancer. We had done research on the response evaluation using the barium swallow as a preliminary study, and the result was that the change in the percent esohpageal stenosis before and after treatment was correlated with the therapeutic response. Our main study was the response evaluation using the MRI including diffusion-weighted images. Of the 31 cases registered cases, treatment response were evaluated in 20 cases. There was no relationship between the treatment response and the MRI findings before and after treatment in the 10 cases that underwent the definitive chemoradiotherapy. Apparent diffusion coefficient (ADC) values and change of them were significantly associated with treatent response in the 10 cases that underwent preoperative chemoratiotherapy.

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Committee Memberships 【 display / non-display 】

Committee Memberships 【 display / non-display 】

• 2015

  -

  Now

    幹事