Updated on 2025/08/22

写真a

 
HATAKENAKA Masamitsu
 
Organization
School of Medicine Department of Diagnostic Radiology Professor
Title
Professor
External link

Research Interests

  • テンソル

  • 画像診断学

  • 消火器癌

  • 機能画像

  • 放射線科学

  • Radiology

  • MRI

  • 筋肉

  • 緩和時間

  • 拡散

  • 骨格筋

  • 拡散係数

  • 心筋

  • ADC

Research Areas

  • Life Science / Radiological sciences

Education

  • Kyushu University   Graduate School, Division of Medicine   Molecular Pharmacology

    - 1993

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  • 九州大学大学院   医学研究科   分子薬理学

    1989 - 1993

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    Country： Japan

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  • Kyushu University   School of Medicine

    1979 - 1985

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    Country： Japan

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  • Kyushu University   Faculty of Medicine

    - 1985

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Research History

  • Sapporo Medical University   School of Medicine   Professor

    2011

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  • Kyushu University

    2006 - 2011

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  • Kyushu University

    2001 - 2006

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  • - Lecturer, Kyushu University

    2001

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  • Kyushu University

    1995 - 2001

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  • Research Associate, Kyushu University

    1995 - 2001

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Professional Memberships

Committee Memberships

  • 日本北欧放射線医学協会   幹事  

    2015   

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    Committee type：Academic society

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Papers

  • Deep learning algorithm to detect fibrosing interstitial lung disease on chest radiographs. International journal

    Hirotaka Nishikiori, Koji Kuronuma, Kenichi Hirota, Naoya Yama, Tomohiro Suzuki, Maki Onodera, Koichi Onodera, Kimiyuki Ikeda, Yuki Mori, Yuichiro Asai, Yuzo Takagi, Seiwa Honda, Hirofumi Ohnishi, Masamitsu Hatakenaka, Hiroki Takahashi, Hirofumi Chiba

    The European respiratory journal   2022.10

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    Language：English   Publishing type：Research paper (scientific journal)  

    BACKGROUND: Antifibrotic therapies are available to treat chronic fibrosing interstitial lung diseases (CF-ILDs), including idiopathic pulmonary fibrosis. Early use of these treatments is recommended to slow deterioration of respiratory function and to prevent acute exacerbation. However, identifying patients in the early stages of CF-ILD using chest radiographs (CRs) is challenging. In this study, we developed and tested a deep learning algorithm to detect CF-ILD using CR images. METHOD: From the image archive of Sapporo Medical University Hospital, 653 CRs from 263 patients with CF-ILDs and 506 from 506 patients without CF-ILD were identified; 921 were used for deep learning and 238 were used for algorithm testing. The algorithm was designed to output a numerical score ranging from 0 to 1, representing the probability of CF-ILD. Using the testing dataset, the algorithm's capability to identify CF-ILD was compared with that of doctors. A second dataset, in which CF-ILD was confirmed using computed tomography images, was used to further evaluate the algorithm's performance. RESULTS: The area under the curve of the receiver operating characteristic curve, which indicates the algorithm's detection capability, was 0.979. Using a score cutoff of 0.267, the sensitivity and specificity of detection were 0.896 and 1.000, respectively. These data showed that the algorithm's performance was non-inferior to that of doctors, including pulmonologists and radiologists; performance was verified using the second dataset. CONCLUSIONS: We developed a deep learning algorithm to detect CF-ILDs using CR images. The algorithm's detection capability was non-inferior to that of doctors.

    DOI： 10.1183/13993003.02269-2021

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  • Diagnosis of prosthetic joint infection at the hip using the standard uptake value of three-phase 99mTc-hydroxymethylene diphosphonate SPECT/CT

    Naoya Yama, Satoshi Nagoya, Shintaro Sugita, Masayuki Koyama, Masamitsu Hatakenaka

    Annals of Nuclear Medicine   2022.4

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    Publishing type：Research paper (scientific journal)   Publisher：Springer Science and Business Media LLC  

    Other Link： https://link.springer.com/article/10.1007/s12149-022-01745-5/fulltext.html

    DOI： 10.1007/s12149-022-01745-5

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  • DWI-related texture analysis for prostate cancer: differences in correlation with histological aggressiveness and data repeatability between peripheral and transition zones

    Chie Tsuruta, Kenji Hirata, Kohsuke Kudo, Naoya Masumori, Masamitsu Hatakenaka

    European Radiology Experimental   6 ( 1 )   2022.3

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    Publishing type：Research paper (scientific journal)   Publisher：Springer Science and Business Media LLC  

    Other Link： https://link.springer.com/article/10.1186/s41747-022-00268-y/fulltext.html

    DOI： 10.1186/s41747-022-00268-y

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  • Abnormal [18F]fluorodeoxyglucose accumulation to tori tubarius in IgG4-related disease

    Ken Nagahata, Masatoshi Kanda, Ryuta Kamekura, Masanari Sugawara, Naoya Yama, Chisako Suzuki, Kenichi Takano, Masamitsu Hatakenaka, Hiroki Takahashi

    Annals of Nuclear Medicine   36 ( 2 )   200 - 207   2022.2

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    Language：English   Publishing type：Research paper (scientific journal)   Publisher：Springer Science and Business Media LLC  

    OBJECTIVES: Tubarial glands (TGs) are recently refocused gland tissues localized near the tori tubarius in the nasopharynx and their clinical relevance is not clear yet. IgG4-related disease (IgG4-RD) is a progressive fibrosing condition and salivary glands are well-affected lesions. The aim of the present study is to examine [18F]fluorodeoxyglucose ([18F]FDG) accumulation to the tori tubarius in IgG4-related disease (IgG4-RD). METHODS: 48 patients with IgG4-RD who underwent positron emission tomography (PET) scanning with [18F]FDG were included and semi-quantitative analysis of [18F]FDG accumulation to tori tubarius was performed along with the clinical features and histopathological analysis. RESULTS: Of the 48 patients, abnormal [18F]FDG accumulation (metabolic tumour volume ≥ 1) to tori tubarius was observed in 15 (31.3%), all of whom had lesions in other head and neck glands. IgG4-RD patients with abnormal [18F]FDG accumulation to tori tubarius showed swollen nasopharyngeal walls around tori tubarius and forceps biopsy of the lesion revealed acinar cells and IgG4-positive plasma cells histologically. Abnormal [18F]FDG accumulation (maximum standard uptake value, metabolic tumour volume and total lesion glycolysis) to tori tubarius correlated with higher IgG4 and lower IgA serum concentrations. CONCLUSIONS: Abnormal [18F]FDG accumulation to tori tubarius can be observed in patients with IgG4-RD and the abnormal [18F]FDG accumulation to tori tubarius can be a clue of TG involvement in IgG4-RD.

    Other Link： https://link.springer.com/article/10.1007/s12149-021-01691-8/fulltext.html

    DOI： 10.1007/s12149-021-01691-8

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  • 胸部X線写真から間質性肺陰影を検出するAIソフトウェアの開発研究

    錦織 博貴, 千葉 弘文, 廣田 健一, 鈴木 朋浩, 本田 聖和, 山 直也, 池田 貴美之, 森 勇樹, 浅井 悠一郎, 大西 浩文, 畠中 正光, 高橋 弘毅

    日本呼吸器学会誌   10 ( 増刊 )   184 - 184   2021.4

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    Language：Japanese   Publisher：(一社)日本呼吸器学会  

    Ichushi

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  • MRI-detected extramural vascular invasion potentiates the risk for pathological metastasis to the lateral lymph nodes in rectal cancer.

    Atsushi Hamabe, Masayuki Ishii, Koichi Onodera, Kenji Okita, Toshihiko Nishidate, Koichi Okuya, Emi Akizuki, Ryo Miura, Takahiro Korai, Masamitsu Hatakenaka, Ichiro Takemasa

    Surgery today   2021.3

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    Language：English   Publishing type：Research paper (scientific journal)  

    PURPOSE: Multidisciplinary treatment for locally advanced rectal cancer requires an accurate assessment of the risk of metastasis to the lateral lymph nodes (LNs). We herein aimed to stratify the risk of pathological metastasis to lateral LNs based on the preoperatively detected malignant features. METHODS: All patients with rectal cancer who underwent surgery from January 2016 to July 2020 were identified. We recorded the TNM factors; perirectal and lateral LN sizes; and MRI findings, including mesorectal fascia involvement, extramural vascular invasion (EMVI), tumor site, and tumor distance from the anal verge. RESULTS: 101 patients underwent rectal resection with lateral lymph node dissection, of whom 16 (15.8%) exhibited pathological metastases to the lateral LNs. Univariate analyses demonstrated that lateral LN metastasis was significantly correlated with mrEMVI positivity (p = 0.0023) and a baseline lateral LN short-axis length of ≥ 5 mm (p < 0.0001). These significant associations were confirmed by a multivariate analysis (p = 0.0254 and 0.0027, respectively). The lateral LN metastasis rate was as high as 44% in cases bearing both risk factors, compared to 0% in cases lacking both risk factors. CONCLUSION: The results elucidated in this study may contribute to risk stratification, which can be used when determining the indications for lateral lymph node dissection.

    DOI： 10.1007/s00595-021-02250-4

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  • CT reconstruction with thick slices not only underestimates lymph node size but also reduces data reproducibility in colorectal cancer. International journal

    Yurina Onuma, Chie Tsuruta, Kenji Okita, Atsushi Hamabe, Keishi Ogura, Ichiro Takemasa, Masamitsu Hatakenaka

    Acta radiologica (Stockholm, Sweden : 1987)   284185120968569 - 284185120968569   2020.10

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    BACKGROUND: Reliable size measurement of lymph node (LN) metastases is important for the evaluation of cancer treatment. However, image analyses without proper settings may result in inappropriate diagnoses and staging. PURPOSE: To investigate whether reconstruction slice thickness in computed tomography (CT) affects measurements of LN size and reproducibility. MATERIAL AND METHODS: We analyzed 48 patients with histological diagnoses of sigmoid colon and rectal cancer who underwent contrast-enhanced CT colonography as part of a surgical treatment preparation. A board-certified radiologist selected 106 LNs whose short-axis diameter was ≥5 mm on 1-mm-thick images; the short-axis diameters were measured on 1- and 5-mm-thick images by the radiologist and residents and compared using Wilcoxon matched-pairs signed rank test. Data variation and reproducibility were evaluated using the F test and Bland-Altman analysis. P<0.05 was considered significant. RESULTS: Short-axis diameters measured on 5-mm-thick images were significantly lower than those measured on 1-mm-thick images (P<0.01), even in the LNs whose short-axis diameters were over twice the slice thickness (P<0.05). Of the 106 LNs, 57 showed short-axis diameter <5 mm on 5-mm-thick images; the maximum short-axis diameter was 6.7 mm on a 1-mm thick image. Data variation was significantly larger on 5-mm thick images than 1-mm-thick images in small LNs (P<0.05) and reproducibility on 5-mm-thick images was inferior to that on 1-mm-thick images. CONCLUSION: Thick reconstruction slices in CT can result in an underestimation of LN size and reduce data reproducibility. When measuring LN size, a thin reconstruction slice would be recommended based on targeted LN size.

    DOI： 10.1177/0284185120968569

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  • IgG4関連尿細管間質性腎炎に対するMRI拡散強調像(DWI-b800)の有用性に関する検討

    雨池 秀憲, 菅原 正成, 神田 真聡, 鈴木 知佐子, 畠中 正光, 高橋 裕樹

    日本臨床免疫学会総会プログラム・抄録集   48回   106 - 106   2020.10

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    Language：Japanese   Publisher：(一社)日本臨床免疫学会  

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  • Lateral Position With Gantry Tilt Further Improves Computed Tomography Image Quality Reconstructed Using Single-Energy Metal Artifact Reduction Algorithm in the Oral Cavity

    Maki Onodera, Kazunori Aratani, Takaharu Shonai, Keishi Ogura, Ken-ichi Kamo, Kazuhiro Ogi, Atsushi Kondo, Masamitsu Hatakenaka

    Journal of Computer Assisted Tomography   44 ( 4 )   553 - 558   2020.7

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    Publishing type：Research paper (scientific journal)   Publisher：Ovid Technologies (Wolters Kluwer Health)  

    DOI： 10.1097/rct.0000000000001029

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  • Spatial resolution of CT

    Masamitsu Hatakenaka

    European Journal of Surgical Oncology   45 ( 9 )   1748 - 1748   2019.9

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    Publishing type：Research paper (scientific journal)   Publisher：Elsevier BV  

    DOI： 10.1016/j.ejso.2019.03.008

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  • Optimizing T1rho and T2 Values for Intervertebral Discs Obtained from the Combined T1rho and T2 Sequence Reviewed

    Imamura Rui, Takashima Hiroyuki, Nakanishi Mitsuhiro, Akatsuka Yoshihiro, Nagahama Hiroshi, Okuaki Tomoyuki, Yoneyama Masami, Hatakenaka Masamitsu

    APPLIED MAGNETIC RESONANCE   50 ( 8 )   959 - 966   2019.8

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    Language：English   Publishing type：Research paper (scientific journal)  

    DOI： 10.1007/s00723-019-01123-x

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  • Optimization of MR Signal Contrast of the Lumbar Cartilaginous Endplates Using Ultra-Short TE

    Hiroyuki Takashima, Mika Yanagida, Rui Imamura, Mitsunori Yoshimoto, Izaya Ogon, Mitsuhiro Nakanishi, Yoshihiro Akatsuka, Tomoyuki Okuaki, Masami Yoneyama, Masamitsu Hatakenaka, Toshihiko Yamashita

    APPLIED MAGNETIC RESONANCE   50 ( 1-3 )   381 - 389   2019.3

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    Language：English   Publishing type：Research paper (scientific journal)  

    DOI： 10.1007/s00723-018-1100-4

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  • Clinical utility of 18F-fluorodeoxyglucose/positron emission tomography in diagnosis of immunoglobulin G4–related sclerosing sialadenitis Reviewed

    Kenichi Takano, Ryoto Yajima, Ryuta Kamekura, Motohisa Yamamoto, Hiroki Takahashi, Naoya Yama, Masamitsu Hatakenaka, Tetsuo Himi

    Laryngoscope   128 ( 5 )   1120 - 1125   2018.5

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    Language：English   Publishing type：Research paper (scientific journal)   Publisher：John Wiley and Sons Inc.  

    DOI： 10.1002/lary.26945

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  • Repeatability analysis of ADC histogram metrics of the uterus. Reviewed

    Onodera K, Hatakenaka M, Yama N, Onodera M, Saito T, Kwee TC, Takahara T

    Acta Radiol.   2018.1

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  • Three cases of implantation of a SureScan(A (R)) system and MRI for investigating causes of pain Reviewed

    Kazunobu Takahashi, Atsushi Sawada, Soshi Iwasaki, Naoya Yama, Hiroyuki Takashima, Maki Onodera, Masamitsu Hatakenaka, Michiaki Yamakage

    JOURNAL OF ANESTHESIA   31 ( 6 )   915 - 917   2017.12

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    Language：English   Publishing type：Research paper (scientific journal)  

    DOI： 10.1007/s00540-017-2413-4

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  • Improvement in automated quantitation of myocardial perfusion abnormality by using iterative reconstruction image in combination with resolution recovery, attenuation and scatter corrections for the detection of coronary artery disease Reviewed

    Taiki Chono, Masahisa Onoguchi, Takayuki Shibutani, Akiyoshi Hashimoto, Tomoaki Nakata, Naoya Yama, Kazufumi Tsuchihashi, Masamitsu Hatakenaka

    ANNALS OF NUCLEAR MEDICINE   31 ( 2 )   181 - 189   2017.2

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    DOI： 10.1007/s12149-016-1146-z

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  • Influence of the Different Primary Cancers and Different Types of Bone Metastasis on the Lesion-based Artificial Neural Network Value Calculated by a Computer-aided Diagnostic System, BONENAVI, on Bone Scintigraphy Images. Reviewed

    Isoda T, BaBa S, Maruoka Y, Kitamura Y, Tahara K, Sasaki M, Hatakenaka M, Honda H

    Asia Ocean J Nucl Med Biol.   5 ( 1 )   49 - 55   2017

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  • Balanced MR cholangiopancreatography with motion-sensitised driven-equilibrium (MSDE) preparation: feasibility of Gd-EOB-DTPA-enhanced biliary examination Reviewed

    T. Nakayama, T. Yoshiura, A. Nishie, Y. Asayama, K. Ishigami, D. Kakihara, Y. Takayama, M. Hatakenaka, M. Obara, H. Honda

    CLINICAL RADIOLOGY   71 ( 12 )   1284 - 1288   2016.12

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    DOI： 10.1016/j.crad.2016.03.019

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  • The signal intensity ratio of the optic nerve to ipsilateral frontal white matter is of value in the diagnosis of acute optic neuritis Reviewed

    Maki Onodera, Naoya Yama, Masato Hashimoto, Takaharu Shonai, Kazunori Aratani, Hiroyuki Takashima, Ken-ichi Kamo, Hiroshi Nagahama, Hiroshi Ohguro, Masamitsu Hatakenaka

    EUROPEAN RADIOLOGY   26 ( 8 )   2640 - 2645   2016.8

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    DOI： 10.1007/s00330-015-4114-4

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  • Trials of vaccines for pancreatic ductal adenocarcinoma: Is there any hope of an improved prognosis? Reviewed

    Toru Mizuguchi, Toshihiko Torigoe, Fukino Satomi, Hiroaki Shima, Goro Kutomi, Shigenori Ota, Masayuki Ishii, Hiroshi Hayashi, Sumiyo Asakura, Yoshihiko Hirohashi, Makoto Meguro, Yasutoshi Kimura, Toshihiko Nishidate, Kenji Okita, Masaho Ishino, Atsushi Miyamoto, Masamitsu Hatakenaka, Noriyuki Sato, Koichi Hirata

    SURGERY TODAY   46 ( 2 )   139 - 148   2016.2

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  • Risk of node metastasis of sentinel lymph nodes detected in level II/III of the axilla by single-photon emission computed tomography/computed tomography Reviewed

    Hiroaki Shima, Goro Kutomi, Fukino Satomi, Hideki Maeda, Tomoko Takamaru, Hidekazu Kameshima, Tosei Omura, Mitsuru Mori, Masamitsu Hatakenaka, Tadashi Hasegawa, Koichi Hirata

    EXPERIMENTAL AND THERAPEUTIC MEDICINE   8 ( 5 )   1447 - 1452   2014.11

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    Language：English   Publishing type：Research paper (scientific journal)  

    DOI： 10.3892/etm.2014.1968

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  • Many Methods of Mediastinal Division Reviewed

    Satoru Yoshida, Masamitsu Hatakenaka

    RADIOLOGY   272 ( 1 )   302 - 303   2014.7

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  • Quantitative Analysis of 1.5-T Whole-Heart Coronary MR Angiograms Obtained with 32-Channel Cardiac Coils: A Comparison with Conventional Quantitative Coronary Angiography Reviewed

    Masato Yonezawa, Motonori Nagata, Kakuya Kitagawa, Shingo Kato, Yeonyee Yoon, Hiroshi Nakajima, Shiro Nakamori, Hajime Sakuma, Masamitsu Hatakenaka, Hiroshi Honda

    RADIOLOGY   271 ( 2 )   356 - 364   2014.5

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    Language：English   Publishing type：Research paper (scientific journal)  

    DOI： 10.1148/radiol.13122491

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  • PARP阻害剤オラパリブの放射線増感効果のメカニズム

    染谷 正則, 三浦 勝利, 坂田 耕一, 中田 健生, 堀 正和, 畠中 正光

    Japanese Journal of Radiology   32 ( Suppl. )   5 - 5   2014.2

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    Language：Japanese   Publisher：(公社)日本医学放射線学会  

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  • Apparent diffusion coefficient is a prognostic factor of head and neck squamous cell carcinoma treated with radiotherapy Reviewed

    Masamitsu Hatakenaka, Katsumasa Nakamura, Hidetake Yabuuchi, Yoshiyuki Shioyama, Yoshio Matsuo, Takeshi Kamitani, Masato Yonezawa, Takashi Yoshiura, Torahiko Nakashima, Mitsuru Mori, Hiroshi Honda

    JAPANESE JOURNAL OF RADIOLOGY   32 ( 2 )   80 - 89   2014.2

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    Language：English   Publishing type：Research paper (scientific journal)  

    DOI： 10.1007/s11604-013-0272-y

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  • Feasibility of low-radiation-dose CT for abdominal examinations with hybrid iterative reconstruction algorithm: Low-contrast phantom study Reviewed

    Masatoshi Kondo, Masamitsu Hatakenaka, Ko Higuchi, Taisuke Fujioka, Takashi Shirasaka, Yasuhiko Nakamura, Katsumasa Nakamura, Takashi Yoshiura, Hiroshi Honda

    Radiological Physics and Technology   6 ( 2 )   287 - 292   2013.7

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    Language：English   Publishing type：Research paper (scientific journal)   Publisher：2  

    DOI： 10.1007/s12194-012-0197-7

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  • Differences in Tibiotalar Joint Alignment During Non-loaded and Axial Loaded Condition in Intact Male Feet Reviewed

    Nozaki Shuhei, Taniguchi Keigo, Takashima Hiroyuki, Watanabe Kota, Hatakenaka Masamitsu, Katayose Masaki

    MEDICINE AND SCIENCE IN SPORTS AND EXERCISE   45 ( 5 )   55 - 56   2013.5

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  • [Optimized magnetic resonance sequences and parameters with operative assisted images for radical prostatectomy at 3 tesla-magnetic resonance image]. Reviewed

    Shirase R, Sakurai Y, Nagahama H, Harada K, Takashima H, Nakanishi M, Harada K, Shishido H, Imamura R, Sakata M, Hatakenaka M

    Nihon Hoshasen Gijutsu Gakkai zasshi   69 ( 5 )   529 - 534   2013.5

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    Language：Japanese   Publishing type：Research paper (scientific journal)   Publisher：5  

    The objective of our study was to optimize magnetic resonance image (MRI) sequences and parameters using operative assisted images (three-dimensional images) for radical prostatectomy at 3 tesla (T) MRI. Five healthy volunteers underwent MRI on the 3.0 T scanner. Various sequences and parameters [Cube (TE/TR = 18, 50, 90 ms/2000 ms), FIESTA (TE/TR/FA = 2.4 ms/5 ms/40 degrees, 90 degrees), fSPGR (TE/TR/FA = 2.3 ms/11.2 ms/20 degrees), slice thickness = 1.2 mm, matrix = 192 x 160] were respectively compared. Several structures of the pelvis (the central zones and transition zones of the prostate, the peripheral zones of the prostate, seminal vesicles, rectum wall, bladder, muscle and fat) were determined. The signal intensities of these structures were measured on reformatted axial images and compared against several structures of the pelvis. Correlation with various sequences and parameters was based on the signal-to-noise ratio (SNR), the contrast ratio (CR) and the presence of artifacts. Student's t-test was used for statistical analysis. With Cube (TE/TR = 50 ms/2000 ms), the average value of visual evaluation with artifacts was high, and SNR and CR were higher than for other sequence and parameters. Optimized MRI sequences and parameters were Cube (TE/TR = 50 ms/2000 ms) which provides improved SNR and CR and the presence of artifacts with operative assisted images for radical prostatectomy. These operative assisted images obtained from Cube (TE/TR = 50 ms/2000 ms) are likely to be useful for surgery.

    DOI： 10.6009/jjrt.2013_JSRT_69.5.529

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  • 3T-MR装置を用いた根治的前立腺全摘除術における手術支援用3D画像作成のための適切なMR撮像シーケンスと撮像条件の検討 Reviewed

    白勢 竜二, 櫻井 佑樹, 長濱 宏史, 原田 邦明, 高島 弘幸, 中西 光広, 原田 耕平, 宍戸 博紀, 今村 塁, 坂田 元道, 畠中 正光

    日本放射線技術学会雑誌   69 ( 5 )   529 - 534   2013.5

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  • Diffusion-weighted imaging (b value = 1500 s/mm2) is useful to decrease false-positive breast cancer cases due to fibrocystic changes Reviewed

    Miho Ochi, Toshiro Kuroiwa, Shunya Sunami, Junji Murakami, Shinichiro Miyahara, Takashi Nagaie, Masafumi Oya, Hidetake Yabuuchi, Masamitsu Hatakenaka

    Breast Cancer   20 ( 2 )   137 - 144   2013.4

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    Language：English   Publishing type：Research paper (scientific journal)   Publisher：2  

    DOI： 10.1007/s12282-011-0319-9

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  • T1 rho is superior to T2 mapping for the evaluation of articular cartilage denaturalization with osteoarthritis: Radiological-pathological correlation after total knee arthroplasty Reviewed

    Yukihisa Takayama, Masamitsu Hatakenaka, Hidetoshi Tsushima, Ken Okazaki, Takashi Yoshiura, Masato Yonezawa, Kei Nishikawa, Yukihide Iwamoto, Hiroshi Honda

    EUROPEAN JOURNAL OF RADIOLOGY   82 ( 4 )   E192 - E198   2013.4

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    DOI： 10.1016/j.ejrad.2012.11.031

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  • Detection of axillary node metastasis using diffusion-weighted MRI in breast cancer Reviewed

    Takeshi Kamitani, Masamitsu Hatakenaka, Hidetake Yabuuchi, Yoshio Matsuo, Nobuhiro Fujita, Mikako Jinnouchi, Michinobu Nagao, Kengo Shirahane, Eriko Tokunaga, Hiroshi Honda

    Clinical Imaging   37 ( 1 )   56 - 61   2013.1

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    DOI： 10.1016/j.clinimag.2012.02.014

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  • Vascular measurement changes observed using postmortem computed tomography Reviewed

    Hideki Hyodoh, Taishi Sato, Maki Onodera, Hirokazu Washio, Tadashi Hasegawa, Masamitsu Hatakenaka

    JAPANESE JOURNAL OF RADIOLOGY   30 ( 10 )   840 - 845   2012.12

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    Language：English   Publishing type：Research paper (scientific journal)  

    DOI： 10.1007/s11604-012-0134-z

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  • Evaluation of cartilage degradation in arthritis using T1 rho magnetic resonance imaging mapping Reviewed

    Hidetoshi Tsushima, Ken Okazaki, Yukihisa Takayama, Masamitsu Hatakenaka, Hiroshi Honda, Toshiaki Izawa, Yasuharu Nakashima, Hisakata Yamada, Yukihide Iwamoto

    RHEUMATOLOGY INTERNATIONAL   32 ( 9 )   2867 - 2875   2012.9

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    Language：English   Publishing type：Research paper (scientific journal)  

    DOI： 10.1007/s00296-011-2140-3

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  • Pharmacokinetic analysis based on dynamic contrast-enhanced MRI for evaluating tumor response to preoperative therapy for oral cancer Reviewed

    Toru Chikui, Erina Kitamoto, Shintaro Kawano, Tsuyoshi Sugiura, Makoto Obara, Arjan W. Simonetti, Masamitsu Hatakenaka, Yoshio Matsuo, Shoichi Koga, Masahiro Ohga, Katsumasa Nakamura, Kazunori Yoshiura

    JOURNAL OF MAGNETIC RESONANCE IMAGING   36 ( 3 )   589 - 597   2012.9

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    Language：English   Publishing type：Research paper (scientific journal)  

    DOI： 10.1002/jmri.23704

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  • Acute Cardiac Impairment Associated With Concurrent Chemoradiotherapy for Esophageal Cancer: Magnetic Resonance Evaluation Reviewed

    Masamitsu Hatakenaka, Masato Yonezawa, Takeshi Nonoshita, Katsumasa Nakamura, Hidetake Yabuuchi, Yoshiyuki Shioyama, Michinobu Nagao, Yoshio Matsuo, Takeshi Kamitani, Taiki Higo, Kei Nishikawa, Taro Setoguchi, Hiroshi Honda

    INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS   83 ( 1 )   E67 - E73   2012.5

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    DOI： 10.1016/j.ijrobp.2011.12.018

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  • 喉頭癌の軟骨浸潤の評価

    北川 未央, 玉川 光春, 兵頭 秀樹, 兵頭 かずさ, 山 直也, 佐藤 大志, 河合 友里子, 晴山 雅人, 畠中 正光, 長谷川 匡

    日本医学放射線学会学術集会抄録集   71回   S339 - S339   2012.2

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  • Subendocardial contractile impairment in chronic ischemic myocardium: assessment by strain analysis of 3T tagged CMR Reviewed

    Michinobu Nagao, Masamitsu Hatakenaka, Yoshio Matsuo, Takeshi Kamitani, Ko Higuchi, Fumiaki Shikata, Mitsugi Nagashima, Teruhito Mochizuki, Hiroshi Honda

    JOURNAL OF CARDIOVASCULAR MAGNETIC RESONANCE   14   14   2012.2

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  • Angiomyolipomas of the Mediastinum and the Lung Reviewed

    Koichiro Morita, Yoshitaka Shida, Kenji Shinozaki, Satoru Uehara, Takashi Seto, Kenji Sugio, Yukito Ichinose, Kenichi Nishiyama, Yoshio Matsuo, Masamitsu Hatakenaka, Hiroshi Honda

    JOURNAL OF THORACIC IMAGING   27 ( 1 )   W21 - W23   2012.1

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  • Exogenous Lipoid Pneumonia Induced by Aspiration of Insecticide Reviewed

    Keisuke Ishimatsu, Takeshi Kamitani, Yoshio Matsuo, Masamitsu Hatakenaka, Shunya Sunami, Mikako Jinnouchi, Michinobu Nagao, Hidetake Yabuuchi, Hiroshi Honda

    JOURNAL OF THORACIC IMAGING   27 ( 1 )   W18 - W20   2012.1

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  • Reduction of the unnecessary dose from the over-range area with a spiral dynamic z-collimator: Comparison of beam pitch and detector coverage with 128-detector row CT Reviewed

    Takashi Shirasaka, Yoshinori Funama, Mutsukazu Hayashi, Shinichi Awamoto, Masatoshi Kondo, Yasuhiko Nakamura, Masamitsu Hatakenaka, Hiroshi Honda

    Radiological Physics and Technology   5 ( 1 )   53 - 58   2012.1

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    DOI： 10.1007/s12194-011-0135-0

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  • Ytterbium-based PARACEST Agent: Feasibility of CEST Imaging on a Clinical MR Scanner Reviewed

    Yukihisa Takayama, Takashi Yoshiura, Akihiro Nishie, Tomohiro Nakayama, Masamitsu Hatakenaka, Naoki Kato, Satoshi Yoshise, Jochen Keupp, Dirk Burdinski, Hiroshi Honda

    MAGNETIC RESONANCE IN MEDICAL SCIENCES   11 ( 1 )   35 - 41   2012

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  • Apparent Diffusion Coefficient Calculated with Relatively High b-Values Correlates with Local Failure of Head and Neck Squamous Cell Carcinoma Treated with Radiotherapy Reviewed

    M. Hatakenaka, Y. Shioyama, K. Nakamura, H. Yabuuchi, Y. Matsuo, S. Sunami, T. Kamitani, T. Yoshiura, T. Nakashima, K. Nishikawa, H. Honda

    AMERICAN JOURNAL OF NEURORADIOLOGY   32 ( 10 )   1904 - 1910   2011.11

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  • Non-Small Cell Lung Cancer: Detection of Early Response to Chemotherapy by Using Contrast-enhanced Dynamic and Diffusion-weighted MR Imaging Reviewed

    Hidetake Yabuuchi, Masamitsu Hatakenaka, Koichi Takayama, Yoshio Matsuo, Shunya Sunami, Takeshi Kamitani, Mikako Jinnouchi, Shuji Sakai, Yoichi Nakanishi, Hiroshi Honda

    RADIOLOGY   261 ( 2 )   598 - 604   2011.11

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  • PRETREATMENT APPARENT DIFFUSION COEFFICIENT OF THE PRIMARY LESION CORRELATES WITH LOCAL FAILURE IN HEAD-AND-NECK CANCER TREATED WITH CHEMORADIOTHERAPY OR RADIOTHERAPY Reviewed

    Masamitsu Hatakenaka, Katsumasa Nakamura, Hidetake Yabuuchi, Yoshiyuki Shioyama, Yoshio Matsuo, Kayoko Ohnishi, Shunya Sunami, Takeshi Kamitani, Taro Setoguchi, Takashi Yoshiura, Torahiko Nakashima, Kei Nishikawa, Hiroshi Honda

    INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS   81 ( 2 )   339 - 345   2011.10

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    DOI： 10.1016/j.ijrobp.2010.05.051

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  • Diagnostic performance in differentiation of breast lesion on digital mammograms: comparison among hard-copy film, 3-megapixel LCD monitor, and 5-megapixel LCD monitor Reviewed

    Takeshi Kamitani, Hidetake Yabuuchi, Yoshio Matsuo, Taro Setoguchi, Shuji Sakai, Takashi Okafuji, Shunya Sunami, Masamitsu Hatakenaka, Nobuhide Ishii, Makoto Kubo, Eriko Tokunaga, Hidetaka Yamamoto, Hiroshi Honda

    CLINICAL IMAGING   35 ( 5 )   341 - 345   2011.9

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    DOI： 10.1016/j.clinimag.2010.08.015

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  • Prediction and monitoring of the response to chemoradiotherapy in oral squamous cell carcinomas using a pharmacokinetic analysis based on the dynamic contrast-enhanced MR imaging findings Reviewed

    Toru Chikui, Shintaro Kawano, Toshiyuki Kawazu, Masamitsu Hatakenaka, Syouzou Koga, Masahiro Ohga, Yoshio Matsuo, Syunya Sunami, Tsuyoshi Sugiura, Yoshiyuki Shioyama, Makoto Obara, Kazunori Yoshiura

    EUROPEAN RADIOLOGY   21 ( 8 )   1699 - 1708   2011.8

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    DOI： 10.1007/s00330-011-2102-x

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  • Correlation between pretreatment or follow-up CT findings and therapeutic effect of autologous peripheral blood stem cell transplantation for interstitial pneumonia associated with systemic sclerosis Reviewed

    Hidetake Yabuuchi, Yoshio Matsuo, Hiroshi Tsukamoto, Shunya Sunami, Takeshi Kamitani, Shuji Sakai, Masamitsu Hatakenaka, Koji Nagafuji, Takahiko Horiuchi, Mine Harada, Koichi Akashi, Hiroshi Honda

    EUROPEAN JOURNAL OF RADIOLOGY   79 ( 2 )   E74 - E79   2011.8

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    DOI： 10.1016/j.ejrad.2011.03.078

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  • Prediction of Local Failures with a Combination of Pretreatment Tumor Volume and Apparent Diffusion Coefficient in Patients Treated with Definitive Radiotherapy for Hypopharyngeal or Oropharyngeal Squamous Cell Carcinoma Reviewed

    Kayoko Ohnishi, Yoshiyuki Shioyama, Masamitsu Hatakenaka, Katsumasa Nakamura, Koichiro Abe, Takashi Yoshiura, Saiji Ohga, Takeshi Nonoshita, Tadamasa Yoshitake, Torahiko Nakashima, Hiroshi Honda

    JOURNAL OF RADIATION RESEARCH   52 ( 4 )   522 - 530   2011.7

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  • A case of localized amyloidosis in the mediastinum, CT, MRI, and 18F-FDG-PET/CT findings Reviewed

    Mikako Jinnouchi, Masamitsu Hatakenaka, Hidetake Yabuuchi, Yoshio Matsuo, Shunya Sunami, Takeshi Kamitani, Masahiro Komori, Yuko Kitajima, Nobuhiro Fujita, Hiroshi Honda

    European Journal of Radiology Extra   77 ( 2 )   e39 - e42   2011.2

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    DOI： 10.1016/j.ejrex.2010.12.003

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  • Detection of non-palpable breast cancer in asymptomatic women by using unenhanced diffusion-weighted and T2-weighted MR imaging: comparison with mammography and dynamic contrast-enhanced MR imaging Reviewed

    Hidetake Yabuuchi, Yoshio Matsuo, Shunya Sunami, Takeshi Kamitani, Satoshi Kawanami, Taro Setoguchi, Shuji Sakai, Masamitsu Hatakenaka, Makoto Kubo, Eriko Tokunaga, Hidetaka Yamamoto, Hiroshi Honda

    EUROPEAN RADIOLOGY   21 ( 1 )   11 - 17   2011.1

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  • Volumetric Asymmetry and Differential Aging Effect of the Human Caudate Nucleus in Normal Individuals: A Prospective MR Imaging Study Reviewed

    Koji Yamashita, Takashi Yoshiura, Akio Hiwatashi, Tomoyuki Noguchi, Osamu Togao, Yukihisa Takayama, Eiki Nagao, Hironori Kamano, Masamitsu Hatakenaka, Hiroshi Honda

    JOURNAL OF NEUROIMAGING   21 ( 1 )   34 - 37   2011.1

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    DOI： 10.1111/j.1552-6569.2009.00403.x

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  • Non-mass-like enhancement on contrast-enhanced breast MR imaging: Lesion characterization using combination of dynamic contrast-enhanced and diffusion-weighted MR images Reviewed

    Hidetake Yabuuchi, Yoshio Matsuo, Takeshi Kamitani, Taro Setoguchi, Takashi Okafuji, Hiroyasu Soeda, Shuji Sakai, Masamitsu Hatakenaka, Makoto Kubo, Eriko Tokunaga, Hidetaka Yamamoto, Hiroshi Honda

    EUROPEAN JOURNAL OF RADIOLOGY   75 ( 1 )   E126 - E132   2010.7

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    DOI： 10.1016/j.ejrad.2009.09.013

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  • Assessment of the sequential change of the masseter muscle by clenching: A quantitative analysis of T-1, T-2, and the signal intensity of the balanced steady-state free precession Reviewed

    Toru Chikui, Tomoko Shiraishi, Kenji Tokumori, Daisuke Inatomi, Masamitsu Hatakenaka, Kenji Yuasa, Kazunori Yoshiura

    ACTA RADIOLOGICA   51 ( 6 )   669 - 678   2010.7

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    DOI： 10.3109/02841851003702180

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  • [Future of diagnostic radiology: prediction of treatment outcome using MRI]. Reviewed

    Hatakenaka M, Yoshiura T, Shioyama Y, Honda H

    Fukuoka igaku zasshi = Hukuoka acta medica   101   41 - 45   2010.3

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  • Detection of Hepatocellular Carcinoma (HCC) Using Super Paramagnetic Iron Oxide (SPIO)-Enhanced MRI: Added Value of Diffusion-Weighted Imaging (DWI) Reviewed

    Akihiro Nishie, Tsuyoshi Tajima, Kousei Ishigami, Yasuhiro Ushijima, Daisuke Okamoto, Masakazu Hirakawa, Yunosuke Nishihara, Akinobu Taketomi, Masamitsu Hatakenaka, Hiroyuki Irie, Kengo Yoshimitsu, Hiroshi Honda

    JOURNAL OF MAGNETIC RESONANCE IMAGING   31 ( 2 )   373 - 382   2010.2

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    DOI： 10.1002/jmri.22059

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  • Joint Position Affects Muscle Proton Diffusion: Evaluation With a 3-T MR System Reviewed

    Masamitsu Hatakenaka, Hidetake Yabuuchi, Shunya Sunami, Takeshi Kamitani, Yukihisa Takayama, Kei Nishikawa, Hiroshi Honda

    AMERICAN JOURNAL OF ROENTGENOLOGY   194 ( 2 )   W208 - W211   2010.2

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    DOI： 10.2214/AJR.09.3167

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  • Effect of clenching on T-2 and diffusion parameters of the masseter muscle Reviewed

    Toru Chikui, Tomoko Shiraishi, Takahiro Ichihara, Toshiyuki Kawazu, Masamitsu Hatakenaka, Yukiko Kami, Kenji Yuasa, Kazunori Yoshiura

    ACTA RADIOLOGICA   51 ( 1 )   58 - 63   2010.2

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    DOI： 10.3109/02841850903280508

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  • Detection of breast cancer by soft-copy reading of digital mammograms: Comparison between a routine image-processing parameter and high-contrast parameters Reviewed

    Takeshi Kamitani, Hidetake Yabuuchi, Hiroyasu Soeda, Yoshio Matsuo, Takashi Okafuji, Shuji Sakai, Taro Setoguchi, Masamitsu Hatakenaka, Nobuhide Ishii, Hiroshi Honda

    ACTA RADIOLOGICA   51 ( 1 )   15 - 20   2010.2

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  • Can calcification predict I-131 accumulation on metastatic lymph nodes in papillary thyroid carcinoma patients receiving I-131 therapy? Comparison of CT, I-131 WBS and F-18-FDG PET/CT Reviewed

    Koichiro Kaneko, Koichiro Abe, Shingo Baba, Yoshitaka Tanabe, Hidetake Yabuuchi, Masamitsu Hatakenaka, Masayuki Sasaki, Hiroshi Honda

    EUROPEAN RADIOLOGY   20 ( 2 )   477 - 483   2010.2

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    DOI： 10.1007/s00330-009-1557-5

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  • Detection of Residual Lymph Node Metastases in High-Risk Papillary Thyroid Cancer Patients Receiving Adjuvant I-131 Therapy The Usefulness of F-18 FDG PET/CT Reviewed

    Koichiro Kaneko, Koichiro Abe, Shingo Baba, Takuro Isoda, Hidetake Yabuuchi, Masayuki Sasaki, Masamitsu Hatakenaka, Hiroshi Honda

    CLINICAL NUCLEAR MEDICINE   35 ( 1 )   6 - 11   2010.1

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    DOI： 10.1097/RLU.0b013e3181c3b737

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  • A Simplified Method of T-1 rho Mapping in Clinical Assessment of Knee Joint Reviewed

    Yukihisa Takayama, Masamitsu Hatakenaka, Takashi Yoshiura, Ken Okazaki, Kei Nishikawa, Tomoyuki Okuaki, Ivan Zimine, Hiroshi Honda

    MAGNETIC RESONANCE IN MEDICAL SCIENCES   9 ( 4 )   209 - 215   2010

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    DOI： 10.2463/mrms.9.209

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  • A fast Look-Locker method for T (1) mapping of the head and neck region Reviewed

    Toru Chikui, Kenji Tokumori, Ryosuke Zeze, Tomoko Shiraishi, Takahiro Ichihara, Masamitsu Hatakenaka, Kazunori Yoshiura

    ORAL RADIOLOGY   25 ( 1 )   22 - 29   2009.6

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    DOI： 10.1007/s11282-009-0005-1

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  • Nonspecific Interstitial Pneumonia After Peripheral Blood Stem Cell Transplantation in an 11-year-old boy Reviewed

    Keiji Matsumoto, Hidetake Yabuuchi, Yoshio Matsuo, Takeshi Kamitani, Taro Setoguchi, Shuji Sakai, Masamitsu Hatakenaka, Aiko Suminoe, Ichiro Yoshino, Masazumi Tsuneyoshi, Hiroshi Honda

    JOURNAL OF THORACIC IMAGING   24 ( 1 )   59 - 61   2009.2

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    DOI： 10.1097/RTI.0b013e31818a0856

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  • Parotid Gland Tumors: Can Addition of Diffusion-weighted MR Imaging to Dynamic Contrast-enhanced MR Imaging Improve Diagnostic Accuracy in Characterization? Reviewed

    Hidetake Yabuuchi, Yoshio Matsuo, Takeshi Kamitani, Taro Setoguchi, Takashi Okafuji, Hiroyasu Soeda, Shuji Sakai, Masamitsu Hatakenaka, Torahiko Nakashima, Yoshinao Oda, Hiroshi Honda

    RADIOLOGY   249 ( 3 )   909 - 916   2008.12

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    DOI： 10.1148/radiol.2493072045

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  • Computed tomographic and magnetic resonance features of inflammatory myofibroblastic tumor of the lung in children Reviewed

    Yukihisa Takayama, Hidetake Yabuuchi, Yoshio Matsuo, Hiroyasu Soeda, Takashi Okafuji, Takeshi Kamitani, Yoshiaki Kinoshita, Naoya Kubokura, Shuji Sakai, Yoshinao Oda, Masamitsu Hatakenaka, Hiroshi Honda

    Radiation Medicine - Medical Imaging and Radiation Oncology   26 ( 10 )   613 - 617   2008.12

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    DOI： 10.1007/s11604-008-0284-1

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  • Computed tomographic and magnetic resonance features of inflammatory myofibroblastic tumor of the lung in children Reviewed

    Yukihisa Takayama, Hidetake Yabuuchi, Yoshio Matsuo, Hiroyasu Soeda, Takashi Okafuji, Takeshi Kamitani, Yoshiaki Kinoshita, Naoya Kubokura, Shuji Sakai, Yoshinao Oda, Masamitsu Hatakenaka, Hiroshi Honda

    RADIATION MEDICINE   26 ( 10 )   613 - 617   2008.12

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  • Enhanced Mass on Contrast-Enhanced Breast MR Imaging: Lesion Characterization Using Combination of Dynamic Contrast-Enhanced and Diffusion-Weighted MR Images Reviewed

    Hidetake Yabuuchi, Yoshio Matsuo, Takashi Okafuji, Takeshi Kamitani, Hiroyasu Soeda, Taro Setoguchi, Shuji Sakai, Masamitsu Hatakenaka, Makoto Kubo, Noriaki Sadanaga, Hidetaka Yamamoto, Hiroshi Honda

    JOURNAL OF MAGNETIC RESONANCE IMAGING   28 ( 5 )   1157 - 1165   2008.11

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    DOI： 10.1002/jmri.21570

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  • Optimal gradation processing parameter for soft-copy reading of digital mammogram: Comparison between the parameter recommended for hard-copy and other parameters Reviewed

    Takeshi Kamitani, Hidetake Yabuuchi, Hiroyasu Soeda, Yoshio Matsuo, Takashi Okafuji, Taro Setoguchi, Shuji Sakai, Masamitsu Hatakenaka, Nobuhide Ishii, Hiroshi Honda

    EUROPEAN JOURNAL OF RADIOLOGY   66 ( 2 )   309 - 312   2008.5

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    DOI： 10.1016/j.ejrad.2007.06.013

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  • Alteration of proton diffusivity associated with passive muscle extension and contraction Reviewed

    Masamitsu Hatakenaka, Yoshio Matsuo, Taro Setoguchi, Hidetake Yabuuchi, Takashi Okafuji, Takeshi Karnitani, Kei Nishikawa, Hiroshi Honda

    JOURNAL OF MAGNETIC RESONANCE IMAGING   27 ( 4 )   932 - 937   2008.4

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    DOI： 10.1002/jmri.21302

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  • Circumscribed mass lesions on mammography: Dynamic contrast-enhanced MR imaging to differentiate malignancy and benignancy Reviewed

    Takashi Okafuji, Hidetake Yabuuchi, Hiroyasu Soeda, Yoshio Matsuo, Takeshi Kamitani, Shuji Sakai, Masamitsu Hatakenaka, Syoji Kuroki, Eriko Tokunaga, Hidetaka Yamamoto, Hiroshi Honda

    Magnetic Resonance in Medical Sciences   7 ( 4 )   195 - 204   2008

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    DOI： 10.2463/mrms.7.195

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  • Effect of passive muscle length change on apparent diffusion coefficient: Detection with clinical MR imaging Reviewed

    Masamitsu Hatakenaka, Hidetake Yabuuchi, Yoshio Matsuo, Takashi Okafuji, Takeshi Kamitani, Taro Setoguchi, Kei Nishikawa, Hiroshi Honda

    Magnetic Resonance in Medical Sciences   7 ( 2 )   59 - 63   2008

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    DOI： 10.2463/mrms.7.59

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  • Apparent diffusion coefficients of breast tumors: Clinical application Reviewed

    Masamitsu Hatakenaka, Hiroyasu Soeda, Hidetake Yabuuchi, Yoshio Matsuo, Takeshi Kamitani, Yoshinao Oda, Masazumi Tsuneyoshi, Hiroshi Honda

    Magnetic Resonance in Medical Sciences   7 ( 1 )   23 - 29   2008

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    DOI： 10.2463/mrms.7.23

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  • In vitro imaging of human monocytic cellular activity using superparamagnetic iron oxide Reviewed

    Akihiro Nishie, Kengo Yoshimitsu, Tomohiro Nakayama, Masamitsu Hatakenaka, Hiroyuki Irie, Yoshiyuki Shioyama, Shuji Matsuura, Yunosuke Nishihara, Koji Kobayashi, Hiroshi Honda

    COMPUTERIZED MEDICAL IMAGING AND GRAPHICS   31 ( 8 )   638 - 642   2007.12

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    DOI： 10.1016/j.compmedimag.2007.07.004

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  • Detection of masses and microcalcifications of breast cancer on digital mammograms: comparison among hard-copy film, 3-megapixel liquid crystal display (LCD) monitors and 5-megapixel LCD monitors: an observer performance study Reviewed

    Takeshi Kamitani, Hidetake Yabuuchi, Hiroyasu Soeda, Yoshio Matsuo, Takashi Okafuji, Shuji Sakai, Akio Furuya, Masamitsu Hatakenaka, Nobuhide Ishii, Hiroshi Honda

    EUROPEAN RADIOLOGY   17 ( 5 )   1365 - 1371   2007.5

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    DOI： 10.1007/s00330-006-0452-6

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  • Familial turner mosaicism 46XX/45XO with brain calcification [5] Reviewed

    Toyoki Maeda, Masahiro Sugano, Jing-Zhi Guan, Jun-Ichi Oyama, Yoshihiro Higuchi, Naoki Makino, Masamitsu Hatakenaka, Hiromi Muta, Masaharu Nakayama, Yukoh Nakazaki, Ryo Kurita, Takashi Hiroyama, Tomokazu Suzuki, Kenzaburo Tani

    Journal of Neuropsychiatry and Clinical Neurosciences   19 ( 3 )   342 - 343   2007

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    DOI： 10.1176/jnp.2007.19.3.342

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  • MR imaging features of pure mucinous carcinoma of the breast Reviewed

    Takashi Okafuji, Hidetake Yabuuchi, Shuji Sakai, Hiroyasu Soeda, Yoshio Matsuo, Takahiro Inoue, Masamitsu Hatakenaka, Naoki Takahashi, Syoji Kuroki, Eriko Tokunaga, Hiroshi Honda

    EUROPEAN JOURNAL OF RADIOLOGY   60 ( 3 )   405 - 413   2006.12

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    DOI： 10.1016/j.ejrad.2006.08.006

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  • Phyllodes tumor of the breast: Correlation between MR findings and histologic grade Reviewed

    Hidelake Yabuuchi, Hiroyasu Soeda, Yoshio Matsuo, Takashi Okafuji, Takashi Eguchi, Shuji Sakai, Syoji Kuroki, Eriko Tokunaga, Shinji Ohno, Kenichi Nishiyama, Masamitsu Hatakenaka, Hiroshi Honda

    RADIOLOGY   241 ( 3 )   702 - 709   2006.12

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    DOI： 10.1148/radiol.2413051470

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  • Pulmonary lesions associated with visceral larva migrans due to Ascaris suum or Toxocara canis: Imaging of six cases Reviewed

    S Sakai, Y Shida, N Takahashi, H Yabuuchi, H Soeda, T Okafuji, M Hatakenaka, H Honda

    AMERICAN JOURNAL OF ROENTGENOLOGY   186 ( 6 )   1697 - 1702   2006.6

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    DOI： 10.2214/AJR.04.1507

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  • A case of lymphangioleiomyomatosis affecting the supraclavicular lymph nodes Reviewed

    T Kamitani, H Yabuuchi, H Soeda, Y Matsuo, T Okafuji, S Sakai, M Hatakenaka, T Minami, H Inoue, A Tanaka, H Kohno, M Tanaka, Y Nakashima, H Honda

    JOURNAL OF COMPUTER ASSISTED TOMOGRAPHY   30 ( 2 )   279 - 282   2006.3

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    DOI： 10.1097/00004728-200603000-00022

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  • Steroid myopathy: Evaluation of fiber atrophy with T2 relaxation time - Rabbit and human study Reviewed

    M Hatakenaka, H Soeda, T Okafuji, H Yabuuchi, S Shiokawa, J Nishimura, H Honda

    RADIOLOGY   238 ( 2 )   650 - 657   2006.2

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    DOI： 10.1148/radiol.2381041720

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  • Gorham's disease of the chest wall - CT and MR characteristics Reviewed

    T Okafuji, H Yabuuchi, H Soeda, N Takahashi, M Hatakenaka, S Sakai, Y Nishihara, N Noda, Inoshima, I, H Honda

    JOURNAL OF THORACIC IMAGING   20 ( 4 )   284 - 287   2005.11

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  • Clinically mild, atypical, and aged craniofacial syndrome is diagnosed as Crouzon syndrome by identification of a point mutation in the fibroblast growth factor receptor 2 gene (FGFR2) Reviewed

    T Maeda, M Hatakenaka, H Muta, M Nakayama, Y Nakazaki, T Hiroyama, T Suzuki, K Tani

    INTERNAL MEDICINE   43 ( 5 )   432 - 435   2004.5

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    DOI： 10.2169/internalmedicine.43.432

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  • Transient uterine myometrial contraction associated with moles Reviewed

    M Hatakenaka, K Yoshimitsu, T Adachi, T Matsuda, N Wake, H Honda

    JOURNAL OF MAGNETIC RESONANCE IMAGING   19 ( 2 )   182 - 187   2004.2

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    DOI： 10.1002/jmri.10445

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  • Xanthogranulomatous cholecystitis: importance of chemical-shift gradient-echo MR imaging Reviewed

    M Hatakenaka, T Adachi, A Matsuyama, M Mori, Y Yoshikawa

    EUROPEAN RADIOLOGY   13 ( 9 )   2233 - 2235   2003.9

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  • Gallium-67 scintigraphy in the diagnosis and the management of chronic sarcoid myopathy Reviewed

    S. Suehiro, Sahasu Shiokawa, S. Taniguchi, Y. Sakai, H. Goda, M. Shiratsuchi, T. Sugimura, M. Hatakenaka, Y. Yoshikawa, S. Ikuyama, J. Nishimura

    Clinical Rheumatology   22 ( 2 )   146 - 148   2003.5

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    DOI： 10.1007/s10067-002-0686-x

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  • Effect of muscular contraction on magnetization transfer detected at 1.5T Reviewed

    Masamitsu Hatakenaka

    Magnetic Resonance in Medical Sciences   2 ( 3 )   151 - 154   2003

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    DOI： 10.2463/mrms.2.151

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  • Expression of the c-myc end c-fos genes as a potential indicator of late radiation damage to the kidney Reviewed

    M Otsuka, M Hatakenaka, K Ishigami, K Masuda

    INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS   49 ( 1 )   169 - 173   2001.1

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  • MR imaging findings of uterine endometrial stromal sarcoma: differentiation from endometrial carcinoma Reviewed

    M Ueda, M Otsuka, M Hatakenaka, S Sakai, M Ono, K Yoshimitsu, H Honda, Y Torii

    EUROPEAN RADIOLOGY   11 ( 1 )   28 - 33   2001

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  • Gene and protein expression of epidermal growth factor measured on the kidney 24 hours after irradiation correlates to late radiation damage Reviewed

    Makoto Otsuka, Masamitsu Hatakenaka

    Journal of JASTRO   13 ( 4 )   197 - 201   2001

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    DOI： 10.11182/jastro1989.13.197

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  • Uterine endometrial stromal sarcoma located in uterine myometrium: MRI appearance Reviewed

    M Ueda, M Otsuka, M Hatakenaka, Y Torii

    EUROPEAN RADIOLOGY   10 ( 5 )   780 - 782   2000

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  • Penetrating atherosclerotic ulcer at the proximal aorta complicated with cardiac tamponade and aortic valve regurgitation Reviewed

    K. I. Yano, N. Makino, H. Hirayama, M. Hatakenaka, H. Matsui, T. Soeda, T. Hadama

    Japanese Circulation Journal   63 ( 3 )   228 - 230   1999

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    DOI： 10.1253/jcj.63.228

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  • Effect of caffeine on the mental calculation Reviewed

    N. Suenaga, T. Inamitsu, M. Hatakenaka, F. Yanaga, F. Shiraishi

    Fukuoka Acta Medica   88 ( 2 )   27 - 29   1997

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  • Phosphatidic acid induces the release of β-glucuronidase but not lactoferrin from electropermeabilized human neutrophils Reviewed

    Wahid Zaman, Takashi Mitsuyama, Masamitsu Hatakenaka, Dongchon Kang, Shigeki Minakami, Koichiro Takeshige

    Journal of Biochemistry   115 ( 2 )   238 - 244   1994

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    DOI： 10.1093/oxfordjournals.jbchem.a124324

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MISC

  • IgG4関連尿細管間質性腎炎に対するMRI拡散強調像(DWI-b800)の有用性に関する検討

    雨池秀憲, 菅原正成, 神田真聡, 鈴木知佐子, 畠中正光, 高橋裕樹

    日本臨床免疫学会総会プログラム・抄録集   48th   2020

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  • SPECT/CTにおけるセンチネルリンパ節集積部位とリンパ節転移についての検討

    島 宏彰, 九冨 五郎, 里見 蕗乃, 高丸 智子, 前田 豪樹, 鈴木 やすよ, 亀嶋 秀和, 大村 東生, 森 満, 畠中 正光, 長谷川 匡, 平田 公一

    日本乳癌学会総会プログラム抄録集   22回   464 - 464   2014.7

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    Ichushi

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  • Epithelioid Sarcomaの画像

    土屋 高旭, 玉川 光春, 河合 有里子, 荒谷 和紀, 兵藤 秀樹, 山 直也, 庄内 孝春, 佐藤 大志, 小野寺 麻希, 鷲尾 嘉一, 浅井 真友美, 畠中 正光

    Japanese Journal of Radiology   32 ( Suppl. )   3 - 3   2014.2

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    Ichushi

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  • 当科の食道がんに対する放射線治療成績

    堀 正和, 中田 健生, 染谷 正則, 高木 克, 三浦 勝利, 北川 未央, 長谷川 智一, 坂田 耕一, 畠中 正光

    Japanese Journal of Radiology   32 ( Suppl. )   5 - 5   2014.2

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  • 当院における中下咽頭癌IMRTの治療成績

    中田 健生, 北川 未央, 堀 正和, 長谷川 智一, 三浦 勝利, 染谷 正則, 舘岡 邦彦, 坂田 耕一, 畠中 正光

    Japanese Journal of Radiology   32 ( Suppl. )   5 - 5   2014.2

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  • 上咽頭癌に対する強度変調放射線治療 当院での治療成績

    北川 未央, 中田 健生, 坂田 耕一, 染谷 正則, 舘岡 邦彦, 堀 正和, 高木 克, 三浦 勝利, 畠中 正光

    Japanese Journal of Radiology   32 ( Suppl. )   5 - 5   2014.2

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  • SPECT/CTによるセンチネルリンパ節の局在の検討

    島 宏彰, 鈴木 やすよ, 里見 蕗乃, 高丸 智子, 亀嶋 秀和, 大村 東生, 九冨 五郎, 畠中 正光, 平田 公一

    日本乳癌学会総会プログラム抄録集   21回   374 - 374   2013.6

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  • PS-271-5 SPECT/CTによるセンチネルリンパ節の局在の検討(PS ポスターセッション,第113回日本外科学会定期学術集会)

    島 宏彰, 鈴木 やすよ, 里見 蕗乃, 高丸 智子, 九冨 五郎, 畠中 正光, 平田 公一

    日本外科学会雑誌   114 ( 2 )   899 - 899   2013.3

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  • SPECT/CTによるセンチネルリンパ節の局在の検討

    島 宏彰, 鈴木 やすよ, 里見 蕗乃, 高丸 智子, 九冨 五郎, 畠中 正光, 平田 公一

    日本外科学会雑誌   114 ( 臨増2 )   899 - 899   2013.3

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    Ichushi

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  • Acute Cardiac Impairment Associated With Concurrent Chemoradiation Therapy for Esophageal Cancer

    M. Hatakenaka, M. Yonezawa, T. Nonoshita, K. Nakamura, H. Yabuuchi, Y. Shioyama, M. Nagao, Y. Matsuo, T. Kamitani, H. Honda

    INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS   84 ( 3 )   S40 - S40   2012.11

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  • The Apparent Diffusion Coefficient of a Primary Lesion Correlates with Local Failure of Head and Neck Squamous Cell Carcinoma Treated with Radiotherapy

    HATAKENAKA Masamitsu, NAKAMURA Katsumasa, SHIOYAMA Yoshiyuki, YABUUCHI Hidetake, NAGAO Michinobu, MATSUO Yoshio, KAMITANI Takeshi, JINNOUCHI Mikako, YONEZAWA Masato, HIGUCHI Ko, YAMASAKI Yuzo, HONDA Hiroshi

    32 ( 1 )   1 - 4   2012.2

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  • Hibernating Myocardium in Chronic Ischemic Heart: Demonstration by 256-MSCT 4-D Color-coded Perfusion Imaging

    Michinobu Nagao, Masamitsu Hatakenaka, Yoshio Matsuo, Shunya Sunami, Takeshi Kamitani, Mikako Zinnouchi, Ko Higuchi, Koichiro Abe, Shingo Baba, Yashushi Mukai, Taiki Higo, Kenji Sunagawa, Hiroshi Honda

    CIRCULATION   122 ( 21 )   2010.11

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  • Pretreatment ADC of the Primary Lesion Correlates with Local Failure in Head and Neck Cancer Treated with Chemoradiotherapy or Radiotherapy

    M. Hatakenaka, K. Nakamura, H. Yabuuchi, Y. Shioyama, Y. Matsuo, K. Ohnishi, S. Sunami, T. Kamitani, T. Yoshiura, H. Honda

    INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS   78 ( 3 )   S445 - S446   2010

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  • Steroid myopathy: Evaluation of fiber atrophy with T2 relaxation time - Rabbit and human study

    M Hatakenaka, H Soeda, T Okafuji, H Yabuuchi, S Shiokawa, J Nishimura, H Honda

    RADIOLOGY   238 ( 2 )   650 - 657   2006.2

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  • 3次元集光照射後肺障害のCT像の経時的変化に関する検討(36 画像診断1, 第46回 日本肺癌学会総会)

    松尾 芳雄, 藪内 英剛, 塩山 善之, 添田 博康, 岡藤 孝史, 神谷 武志, 畠中 正光, 中村 和正, 本田 浩, 坂井 修二

    肺癌   45 ( 5 )   612 - 612   2005.11

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  • Transient uterine myometrial contraction associated with moles

    M Hatakenaka, K Yoshimitsu, T Adachi, T Matsuda, N Wake, H Honda

    JOURNAL OF MAGNETIC RESONANCE IMAGING   19 ( 2 )   182 - 187   2004.2

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  • Xanthogranulomatous cholecystitis: importance of chemical-shift gradient-echo MR imaging

    M Hatakenaka, T Adachi, A Matsuyama, M Mori, Y Yoshikawa

    EUROPEAN RADIOLOGY   13 ( 9 )   2233 - 2235   2003.9

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    Language：English   Publishing type：Rapid communication, short report, research note, etc. (scientific journal)  

    DOI： 10.1007/s00330-002-1731-5

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  • Effect of muscular contraction on magnetization transfer detected at 1.5T

    Magnetic Resonance in Medical Sciences   2(3); 151-154   2003

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  • Effect of muscular contraction on magnetization transfer detected at 1.5T

    Magnetic Resonance in Medical Sciences   2(3); 151-154   2003

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  • Effects of aging on muscle T2 relaxation time - Difference between fast- and slow-twitch muscles

    M Hatakenaka, M Ueda, K Ishigami, M Otsuka, K Masuda

    INVESTIGATIVE RADIOLOGY   36 ( 12 )   692 - 698   2001.12

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  • Early expression of c-myc and c-fos genes as potential early indicators for late radiation damage of the mouse kidney measured by BUN evaluation

    M Otsuka, M Hatakenaka, K Masuda

    RADIOLOGY   217   156 - 156   2000.11

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  • Epidermal growth factor gene expression: Another potential early indicator for late radiation damage of the mouse kidney

    M Otsuka, M Hatakenaka, K Ishigami, K Masuda

    RADIOLOGY   217   156 - 156   2000.11

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  • 増殖関連遺伝子は晩発性放射線腎障害の早期指標になりうるか

    大塚 誠, 畠中 正光, 石神 康生, 増田 康治

    日本放射線腫瘍学会誌   11 ( Suppl.1 )   160 - 160   1999.11

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    Ichushi

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  • 腎放射線晩発障害の早期指標としての増殖関連遺伝子

    大塚 誠, 畠中 正光, 石神 康生, 増田 康二

    日本医学放射線学会雑誌   59 ( 2 )   S111 - S111   1999.2

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    Ichushi

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  • Magnetization transfer contrast(MTC)に及ぼす筋収縮の影響について

    畠中 正光, 大塚 誠, 石神 康生

    日本医学放射線学会雑誌   59 ( 2 )   S56 - S57   1999.2

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    Ichushi

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  • Acute suppurative perithyroiditis: MR findings

    M Hatakenaka, J Murakami, S Murayama, S Sakai, N Hashiguchi, Y Zaizen, S Suita, K Sakamoto, K Kusuhara, K Masuda

    PEDIATRIC RADIOLOGY   27 ( 4 )   353 - 355   1997.4

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  • Acute suppurative perithyroiditis: MR findings

    M Hatakenaka, J Murakami, S Murayama, S Sakai, N Hashiguchi, Y Zaizen, S Suita, K Sakamoto, K Kusuhara, K Masuda

    PEDIATRIC RADIOLOGY   27 ( 4 )   353 - 355   1997.4

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  • The Ca2+-activation profile of rabbit fast skeletal myofibrils is not affected by troponin T isoforms

    M Hatakenaka

    BIOMEDICAL RESEARCH-TOKYO   17 ( 1 )   95 - 100   1996.2

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  • The Ca2+-activation profile of rabbit fast skeletal myofibrils is not affected by troponin T isoforms

    Masamitsu Hatakenaka

    Biomedical Research   17 ( 1 )   95 - 100   1996

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    Language：English   Publisher：Biomedical Research Foundation  

    DOI： 10.2220/biomedres.17.95

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  • EFFECT OF REMOVAL AND RECONSTITUTION OF TROPONIN-C AND TROPONIN-I ON THE CA2+-ACTIVATED TENSION DEVELOPMENT OF SINGLE GLYCERINATED RABBIT SKELETAL-MUSCLE FIBERS

    M HATAKENAKA, OHTSUKI, I

    EUROPEAN JOURNAL OF BIOCHEMISTRY   205 ( 3 )   985 - 993   1992.5

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  • REPLACEMENT OF 3 TROPONIN COMPONENTS WITH CARDIAC TROPONIN COMPONENTS WITHIN SINGLE GLYCERINATED SKELETAL-MUSCLE FIBERS

    M HATAKENAKA, OHTSUKI, I

    BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS   181 ( 3 )   1022 - 1027   1991.12

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Awards

  • JJR Excellent reviewer award

    2021.4   Japan Radiological Society  

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  • Silver distinguished reviewer achevement

    2019.3   America Roentgen Ray Society  

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  • Certificate

    2018   Japan Radiological Society  

    HATAKENAKA Masamitsu

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  • Peer Review Certificate

    2017   European Society of Radiology  

    HATAKENAKA Masamitsu

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  • Special distinguished Reviewer

    2016.5   ISMRM  

    HATAKENAKA Masamitsu

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  • Certificate of Merit

    2015.12   RSNA  

    HATAKENAKA Masamitsu

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Research Projects

  • 直腸癌の個別的リスク評価を目的とした人工知能MRI解析アルゴリズムの確立

    Grant number：22H03150  2022.4 - 2025.3

    日本学術振興会  科学研究費助成事業  基盤研究(B)

    竹政 伊知朗, 渡辺 昌彦, 内藤 剛, 浜部 敦史, 奥谷 浩一, 石井 雅之, 畠中 正光, 森 正樹, 土岐 祐一郎, 江口 英利, 坂井 義治, 肥田 侯矢, 吉野 孝之, 沖 英次

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    Grant amount：\17420000 （ Direct Cost: \13400000 、 Indirect Cost：\4020000 ）

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  • Evaluation of rectal cancer aggressiveness based on conductivity imaging

    Grant number：18K07635  2018.4 - 2022.3

    Japan Society for the Promotion of Science  Grants-in-Aid for Scientific Research Grant-in-Aid for Scientific Research (C)  Grant-in-Aid for Scientific Research (C)

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    Grant amount：\4290000 （ Direct Cost: \3300000 、 Indirect Cost：\990000 ）

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  • Establishment of early detection and treatment assessment of pulmonary hypertension by PC-cine MRI

    Grant number：16K10323  2016.4 - 2019.3

    Japan Society for the Promotion of Science  Grants-in-Aid for Scientific Research  Grant-in-Aid for Scientific Research (C)

    Murayamma Sadayuki

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    Grant amount：\4550000 （ Direct Cost: \3500000 、 Indirect Cost：\1050000 ）

    Phase contrast MRI (PC-MRI) can determine pulmonary hemodynamics noninvasively. Pulmonary hypertension causes changes in pulmonary hemodynamics and is a factor for acute exacerbation and death in interstitial lung diseases (ILD). The purpose of this study was to determine the association between pulmonary hemodynamics measured by PC-MRI and episodes of acute exacerbations and death in patients with ILD related pulmonary hypertension. Reduction in right cardiac output, as detected by PC-MRI, was associated with acute exacerbation and increased mortality in ILD. MR examination to detect right ventricular dysfunction is useful for predicting the poor prognosis in fibrotic ILD patients, even if they are not combined with pulmonary hypertension.

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  • Predicting treatment effect and prognosis by using IVIM

    Grant number：26461831  2014 - 2016

    Japan Society for the Promotion of Science  Grants-in-Aid for Scientific Research  Grant-in-Aid for Scientific Research (C)

    Hatakenaka Masmaitsu

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    Authorship：Principal investigator  Grant type：Competitive

    Grant amount：\4550000 （ Direct Cost: \3500000 、 Indirect Cost：\1050000 ）

    In total, 28 patients with head and neck cancer who were treated with (chemo)radiotherapy were enrolled in the present study. However, 8 patients were excluded due to poor image quality and/or inadequate clinical data. Further, patients with nasopharyngeal cancer were excluded because its D is lower and sensitive to chemoradiotherapy. Finally, 10 patients were statistically analyzed.
    The pre-treatment D value for 6 patients without recurrence was 0.640±0.168 mm2/s and that for 4 ones with recurrence was 0.921±0.204 mm2/s and statistically significant difference was observed (p<0.05). The ratio of D value increase at 10Gy was 0.350±0.533 without recurrence and 0.04±0.174 with recurrence but statistical significance was not observed. F(perfusion fraction) and D*(perfusion) derived from IVIM method show wide variation. Signal intensity at b=25 s/mm2 was lower than that at b=50 s/mm2 in some cases. Thus, F and D* were not analyzed.

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  • MRI of locally advanced esophageal cancer: response evaluation to chemoradiotherapy

    Grant number：23591773  2011 - 2013

    Japan Society for the Promotion of Science  Grants-in-Aid for Scientific Research  Grant-in-Aid for Scientific Research (C)

    KIYOHISA Hiraka, TSURUMARU Daisuke, HONDA Hiroshi, MATSUO Yoshio, MIYASAKA Mitsutoshi, NISHIMUTA Yusuke, SASAKI Tomonari

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    Grant amount：\5330000 （ Direct Cost: \4100000 、 Indirect Cost：\1230000 ）

    In this study, we studied the image parameters to predict the therapeutic effect of radiotherapy/chemoradiotherapy for esophageal cancer. We had done research on the response evaluation using the barium swallow as a preliminary study, and the result was that the change in the percent esohpageal stenosis before and after treatment was correlated with the therapeutic response. Our main study was the response evaluation using the MRI including diffusion-weighted images. Of the 31 cases registered cases, treatment response were evaluated in 20 cases. There was no relationship between the treatment response and the MRI findings before and after treatment in the 10 cases that underwent the definitive chemoradiotherapy. Apparent diffusion coefficient (ADC) values and change of them were significantly associated with treatent response in the 10 cases that underwent preoperative chemoratiotherapy.

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  • Study on optimization by using functional images for low-risk and high-precision radiotherapy for lung cancer

    Grant number：22591387  2010.4 - 2014.3

    Japan Society for the Promotion of Science  Grants-in-Aid for Scientific Research  Grant-in-Aid for Scientific Research (C)

    SHIOYAMA Yoshiyuki, NAKAMURA Katsumasa, ARIMURA Hidetaka, YOSHITAKE Tadamasa, HONDA Hiroshi, HATAKENAKA Masamitsu, ABE Kouichirou

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    Grant amount：\3510000 （ Direct Cost: \2700000 、 Indirect Cost：\810000 ）

    In the high-precision radiotherapy (intensity modulated radiation therapy and stereotactic radiation therapy) for lung cancer patients, we quantitatively compared the dose distribution between the treatment plans optimized by using functional images and the treatment plans optimized by using anatomical images only. The optimization using functional images was considered to be useful in minimizing the decrease of pulmonary function, and this approach was thought to be more beneficial to the high-risk patients in particular. Furthermore, this functional-image-guided optimization was suggested to become more effective by using non-coplanar beams in addition to coplanar beams.

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  • Evaluation of neuromuscular disease activity by diffusion tensor imaging

    Grant number：22591341  2010 - 2013

    Japan Society for the Promotion of Science  Grants-in-Aid for Scientific Research  Grant-in-Aid for Scientific Research (C)

    HATAKENAKA Masamitsu, TAKASHIMA Hiroyuki, TMATSUO Yoshio, OHYAGI Yasumasa, SAKAE Nobutaka, NISHIKAWA Kei, HONDA Hiroshi, SUNAMI Shunya, KAMITANI Takeshi

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    Authorship：Principal investigator  Grant type：Competitive

    Grant amount：\4160000 （ Direct Cost: \3200000 、 Indirect Cost：\960000 ）

    The fractional anisotropy of myopathy lesion was decreased by 38%, and lambuda 1, 2, and 3 were increased by 59%, 69%, and 79% compared to normal muscles, respectively. These results suggest that parameters related to diffusion tensor imaging are useful for detecting myopathy lesions. However, when comparing absolute parameter values and setting thresholds, some attentions are needed regarding the MR system characteristics.

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  • Evaluation of myocardial ischemia with cine-tagging and first-pass perfusion MRI

    Grant number：22591339  2010 - 2012

    Japan Society for the Promotion of Science  Grants-in-Aid for Scientific Research  Grant-in-Aid for Scientific Research (C)

    NAGAO Michinobu, HATAKENAKA Masamitsu, MATSUO Yoshio, SUNAMI Shunya, KAMITANI Takeshi, HONDA Hiroshi, MOCHIZUKI Teruhito, HIGASHINO Hiroshi

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    Grant amount：\3770000 （ Direct Cost: \2900000 、 Indirect Cost：\870000 ）

    The purpose of this study was to quantify myocardial strain on the subendocardial and epicardial layers of the left ventricle (LV) using tagged cardiovascular magnetic resonance (CMR) and to investigate the transmural degree of contractile impairment in the chronic ischemic myocardium. In conclusion, analysis of 3T tagged MR can non-invasively quantify the transmural degree of left ventricular deformation and demonstrate predominate impairment of subendocardial strain in the chronic ischemic myocardium at rest.

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  • Development of novel MR parameters associated with left ventricular contraction

    Grant number：18591353  2006 - 2008

    Ministry of Education, Culture, Sports, Science and Technology  Grants-in-Aid for Scientific Research(基盤研究(C))  基盤研究(C)

    Masamitsu HATAKENAKA, Hidetake YABUUCHI, Kouji TODAKA, Kei NISHIKAWA

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    Authorship：Principal investigator  Grant type：Competitive

    Grant amount：\4100000 （ Direct Cost: \3500000 、 Indirect Cost：\600000 ）

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  • 大腿骨頭の局所血流量を評価する新たな磁気共鳴パラメータ開発

    Grant number：18659350  2006 - 2008

    日本学術振興会  科学研究費助成事業  萌芽研究

    本田 浩, 畠中 正光, 薮内 英剛

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    Grant amount：\3100000 （ Direct Cost: \3100000 ）

    1.5T-MRI装置を用いて、Spin Echo法にてEcho timeを変化させて(Repetition time2000msec, Echo time 20-120 msec)、大腿骨頭にRegion of Interest(ROI)を設定し、ROIのSignal intensityの変化を以下の数式にfittingし、T2緩和時間の測定を行った。SI=Me-(TE/T2)SI: Signal intensity M:Spin density TE: Echo time T2:T2緩和時間
    頭側の総腸骨動脈に対しSaturation pulseを印加した場合と印加しなかった場合とでT2緩和時間を比較検討した。
    Saturation pulseを印加しない場合では、T2緩和時間は77.6±4.4 msecであったが、大腿骨頭の上下にsaturation pulseを印加した場合は、75.6±5.2msecと、T2緩和時間は2msec程度短縮した。(p<0.05)しかしこの差は小さく、T2緩和時間の2.5%程度であり、計算上は有意差を認めたが、画像から視覚的に両者の差を判断することは困難であった。
    緩和時間の差を用いる方法では、差はわずかであったので、弱いMotion probing Gradient(MPG)を印加して、Diffusion Weighted Image(DWI)を撮像し、Apparent Diffusion Coefficient(ADC)の違いから、血流(perfusion)の違いを検出する方法を試みた。3.OT MRI装置を用い、血管造影検査時の止血用具にて片側の外腸骨動脈の圧迫前後で、弱いMPGを印加してDWIを撮影しDWI上の信号強度変化,ADCの変化を計算した。結果は予想とは逆に、圧迫が無い状態、つまり血流(perfusion)が多い状態の方がDWI上での信号減衰が弱くADCが小さな値を示す傾向にあった。B0,B1の不均一に伴う骨髄脂肪信号の抑制不均一などの影響があるのかもしれないと考えられるが、詳細に関しては更なる検討が必要と考えられる。

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  • Evaluation of cardiac muscle function with MR imaging

    2005

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    Grant type：Competitive

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  • Evaluation of radiotherapy respnse with MR imaging

    2005

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    Grant type：Competitive

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  • NEW METHOD OF EVALUATING MUSCLE FUNCTION WITH MAGNETIC RESONANCE IMAGER

    Grant number：15500365  2003 - 2005

    Ministry of Education, Culture, Sports, Science and Technology  Grants-in-Aid for Scientific Research(基盤研究(C))  基盤研究(C)

    Masamitsu HATAKENAKA, 前田 豊樹, 足立 利貞, Kengo YOSHIMITSU, Hiroshi HONDA, 薮内 英剛, 高橋 直幹, Hidetake YABUUCHI

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    Authorship：Principal investigator  Grant type：Competitive

    Grant amount：\3500000 （ Direct Cost: \3500000 ）

    Purpose :To determine whether muscle fiber atrophy associated with steroid myopathy can be detected with T2 relaxation time.Materials and Methods:Animal and human studies were approved by the ethics committee. Informed consent was obtained. Twelve rabbits were divided into a group that received 3 mg/kg of triamcinolone subcutaneously each day for 10 consecutive days (n_6) and a control group that received saline (n_6). Magnetic resonance (MR) imaging was performed before and after treatment. T2 and fat deposition ratio (FDR) of soleus and gastrocnemius muscles before and after treatment and between control rabbits and rabbits treated with steroids were compared by using two-way repeated analysis of variance and Bonferroni post hoc test to evaluate effects of steroid treatment. After imaging, rabbits were sacrificed. Extracellular space ratio (ECSR) and fiber diameter were examined. Correlation among T2, ECSR, and diameter of type 2 muscle fibers was analyzed with a Pearson correlation test with Bonferroni correction in gastrocnemius to determine factors affecting T2. In humans, T2 relaxation time and FDR of both muscles were compared between volunteers not treated with steroids and patients treated with steroids by using an unpaired t test to evaluate the effects of steroids.Results :In rabbits, T2 of gastrocnemius muscle was significantly (P_.01) longer after steroid treatment than before steroid treatment and was also significantly (P_.01) longer than after saline administration. T2 of the gastrocnemius showed no significant difference in control rabbits before or after saline administration or in control rabbits and rabbits before steroid administration. T2 of the soleus muscle or FDR of either muscle showed no significant difference. There was a significant correlation (P_.01) among T2, ECSR, and diameter of type 2 muscle fibers in the gastrocnemius. In humans, T2 of the gastrocnemius was significantly (P_.01) longer in patients than in volunteers. T2 of the soleus or FDR of eithermuscle showed no significant difference.Conclusion :Muscle fiber atrophy associated with steroid myopathy is detectable as prolongation of T2 relaxation time in the gastrocnemius muscle ; the authors believe prolongation of T2 relaxation time is mainly due to increased ECSR reflecting type 2 muscle fiber atrophy.

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  • 放射線防護剤の新たな投与法の開発

    Grant number：15659281  2003 - 2005

    日本学術振興会  科学研究費助成事業  萌芽研究

    足立 利貞, 吉武 慎一郎, 前田 豊樹, 上田 真信, 畠中 正光, 福谷 龍郎

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    Grant amount：\3300000 （ Direct Cost: \3300000 ）

    本年度は、放射線照射によるDNA損傷の一般的な評価方法である小核試験法を用いて以下のことを調べた。1.ラットの肝臓に放射線を照射した場合の放射線の線量と小核出現頻度の関係。2.放射線防護剤(アミフォスチン)を局所投与または全身投与した後に放射線を照射した場合の放射線防護剤の投与経路および用量に対する小核出現頻度の依存性。3.各投与経路における放射線防護剤の用量と小核出現頻度の関係。
    方法は以下のとおりである。1.オスのフィッシャー344ラットをペントバルビタールナトリウム60mg/kg腹腔内注射により麻酔する。2.門脈(局所投与)または下大静脈(全身投与)にカニューレを挿入し、生理食塩水または放射線防護剤を注入する。3.肝臓を中心に放射線を照射する。4.肝臓の一部を切除して肝細胞の分裂を促進する。5.前潅流液およびコラーゲナーゼ液で肝臓を潅流する。6.単離された肝細胞を固定・DAPI染色後に蛍光顕微鏡で観察する。
    結果は以下のとおりである。1.放射線の線量と小核出現頻度の間には直線関係が認められた(P<0.01)。2.分散分析の結果、放射線防護剤の投与経路および用量により小核出現頻度に差があると認められた(投与経路:P<0.05、用量:P<0.01)。3.各投与経路において、放射線防護剤の用量と小核出現頻度の間には直線関係が認められた(局所投与:P<0.01、全身投与:P<0.05)。局所投与の回帰直線の傾きは全身投与の約2倍であった。
    結論として、同量の放射線防護剤を投与した場合、局所投与のほうが全身投与より放射線防護効果が高いことが明らかになった。

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  • New approach for evaluating muscle function by using MR imaging

    Grant number：12832035  2000 - 2002

    Ministry of Education, Culture, Sports, Science and Technology  Grants-in-Aid for Scientific Research(基盤研究(C))  基盤研究(C)

    Masamitsu HATAKENAKA, 大塚 誠, 増田 康治, Kengo YOSHIMITU, Naoki MAKINO, Toshisada ADACHI

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    Authorship：Principal investigator  Grant type：Competitive

    Grant amount：\4000000 （ Direct Cost: \4000000 ）

    1) RATIONALE AND OBJECTIVES. To determine whether the T2 relaxation time of skeletal muscle is affected by aging and to compare the effects of aging between fast- and slow-twitch muscles. METHODS. T2 relaxation times of the soleus and gastrocnemius muscles were examined in 59 healthy human subjects 22 to 76 years of age, using a clinical magnetic resonance imaging. In mice, T2 relaxation times, fat ratios, and extracellular space ratios of the psoas muscles were examined (old group of 7 mice, 24 to 26 months; young group of 7 mice, 8 to 10 weeks). RESULTS. T2 relaxation time of the gastrocnemius muscle increased significantly with aging (r=0.53, p<0.01). While that of the soleus muscle did not. T2 relaxation time of the psoas muscle was significantly linger (p<0.05) and extracellular space ratio of the psoas muscle was significantly wider (P<0.01) in old than in young mice. No significant difference in fat ratio was observed between old and young mice. A significant positive correlation was seen between extracellular space ratio and T2 relaxation time (r=0.84, p<0.01). CONCLUSION. T2 relaxation time of fast-twitch muscle increases with aging, due mainly to increased extracellular space reflecting age-related type II fiber atrophy.2) To determine the T2 relaxation time of muscle was affected by steroid treatment (steroid myopathy), T2 relaxation time of the soleus, gastrocnemius and tibialis anterior muscles were measured before and after steroid injection in rabbit. The T2 relaxation time of the gastrocnemius and tibialis anterior muscles (fast-twitch) increased significantly but not in the soleus muscle (slow-twitch). Extracellular space ratio of the gastrocnemius and tibialis anterior muscles was significantly wider (p<0.01) in steroid-treated than in control. T2 relaxation time is a potential indicator for steroid-induced myopathy.

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  • Development of new gene therapy for treatment of atherosclerosis using anti-apoptotic genes

    Grant number：12670678  2000 - 2001

    Japan Society for the Promotion of Science  Grants-in-Aid for Scientific Research  Grant-in-Aid for Scientific Research (C)

    SUGANO Masahiro, HATAKENAKA Masamitu, MAKINO Naoki

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    Grant amount：\3400000 （ Direct Cost: \3400000 ）

    1) Growth of HUVEC transfected with sTNFRI vector also increased significantly compared to those transfected with control vector. Accumulation of sTNFRI significantly increased in conditioned medium from HUVEC transfected with sTNFRI vector compared to those transfected with control vector. HUVEC transfected with sTNFRI vector not only increased sTNFRI but also prevented shedding of sTNFRI from TNFRI. The TNF-a-induced internucleosomic fragmentation was also significantly prevented in HUVEC transfected with sTNFRI vector compared to those transfected with control vector.
    2) The incubation of HUVEC with oxLDL increased LOX-1 mRNA levels and CPP32-like protease activity, and induced apoptosis. Preincubation of HUVEC with nifedipine before incubation with oxLDL significantly suppressed the increase in LOX-1 mRNA levels and CPP32-like protease activity, preventing (7)___ in a dose-dependent manner. These results suggest that nifedipine blocks the suicide pathway leading to the apoptosis of endothelial cells by decreasing LOX-1 mRNA levels and CPP32-like protease activity.
    3) Here we report that direct injection of a sTNFRI expression plasmid DNA to the myocardium reduces infarct size in experimental rat AMI. Treatment with sTNFRI expression plasmid DNA reduced the TNF-alpha bioactivity in the myocardium and the apoptosis of cardiomyocytes. These findings suggest that the anti-TNF-alpha therapy by sTNFRI can be a new strategy for treatment of AMI.

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  • Early detection of the effect of aging or drug on muscle using MR

    2000

    Grant-in-Aid for Scientific Research 

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    Grant type：Competitive

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  • DEVELOPMENT OF THE EARLY INDICATOR FOR LATE RADIATION DAMAGE

    Grant number：10670858  1998 - 1999

    Japan Society for the Promotion of Science  Grants-in-Aid for Scientific Research  Grant-in-Aid for Scientific Research (C)

    OTSUKA Makoto, HATAKENAKA Masamitsu

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    Grant amount：\3200000 （ Direct Cost: \3200000 ）

    We have previously described the increased proliferation and appearance of abnormally large nuclei in renal proximal tubule cells after radiation. A model has been proposed that the large nuclear cells might be dying and the increased proliferation might lead to mitotic death of these cells and cause functional damage. We measured the expression of c-fos and c-myc taking the ratio of densities of bands for irradiated portion to unirradiated portion of the kidney after RT-PCR procedure, and found the c-fos and c-myc expression increased very early (24 hours) after irradiation, probably representing increased DNA synthesis. The incidence of high c-myc expression increased according to radiation dose from 9 to 15 Gy. Then we measured the c-fos and c-myc expression 24 hours after 12 Gy irradiation, and followed BUN values representing the renal function of irradiated and right nephrectomized mice for 9 months after irradiation. Most of c-fos and c-myc positive mice showed increased BUN level, while all mice with negative c-fos and c-myc showed no BUN change. Measuring c-fos and c-myc expression seems to be a potential very early indicator of late radiation damage of kidney.

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  • The involvement of matrix metalloproteinase (MMP-7) in invasion and metastasis of gastrointestinal carcinoma.

    Grant number：10671198  1998 - 1999

    Japan Society for the Promotion of Science  Grants-in-Aid for Scientific Research  Grant-in-Aid for Scientific Research (C)

    YOSHIKAWA Yasuji, SHIBUTA Kenji, SADANAGA Noriaki, MORI Masaki, UTSUNOMIYA Tohru, HATAKENAKA Masamitsu

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    Grant amount：\3200000 （ Direct Cost: \3200000 ）

    We have investigated the expression of MMP-7 in gastrointestinal carcinomas. In colon carcinoma, MMP-7 expression was correlated with the clinical stage (Mori et al. 1995 Cancer) and in gastric carcinoma, it was significantly correlated with lymph node metastasis and lymphatic and vascular permeation (Honda et al. 1996 Gut). Now we analyzed 48 esophageal carcinoma patients regarding MMP-7 expression and revealed MMP-7 to be significantly correlated with lymph node metastasis and patient prognosis. In multivariate analysis regarding the prognosis, MMP-7 was a prognostic factor independetly of classical clinicopathological factor (p=0.0005) (Yamashita et al. Clin. Cancer Res. in press). MMP-7 was reported to be expressed in carcinoma cells of esophageal carcinoma tissues and our immunohistochemical results regarding esophageal carcinoma revealed MMP-7 protein to be expressed in carcinoma cells themselves as well. However, no esophageal carcinoma cell line in 13 was recognized to express MMP-7 mRNA expression, which showed the discrepancy of MMP-7 expression. This suggested MMP-7 expression to be induced by the carcinoma-host interaction. Therefore we transfected MMP-7 cDNA into KYSE150 (KY-7), which does not constitutively express MMP-7, and compared it with the parent cells (KY-P) to reveal their differences. KY-7 overexpressed cyclin D1 and c-myc and downregulated p27 protein after confluent state compared with KY-P and showed an increased uptake of BrdU, which suggested KY-7 to augment the proliferative capacity of cells. Both lines also showed the great difference of growth rate especially in dense concentration of cells. While MMP-u was known to be involved in tumorigenesis, but our result revealed a novel mechanism of involvement in tumorigenesis by MMP-7.

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  • DEVELOPMENT OF THE EARLY INDICATOR FOR LATE RADIATION DAMAGE OF KIDNEY

    Grant number：08671039  1996 - 1997

    Japan Society for the Promotion of Science  Grants-in-Aid for Scientific Research  Grant-in-Aid for Scientific Research (C)

    OTSUKA Makoto, HATAKENAKA Masamitsu

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    Grant amount：\2300000 （ Direct Cost: \2300000 ）

    We have previously described the increased proliferation and appearance of abnormally large nuclei in renal proximal tubule cells after radiation. A model has been proposed that the large nuclear cells might be dying and the increased proliferation might lead to mitotic death of these cells and cause functional damage. We measured the amount of c-myc transcript taking the ratio of densities of bands for irradiated left kidney to unirradiated right kidney after RT-PCR procedure on 24 hours after 9,12 and 15 Gy irradiation, and found positive in 1 out of 10 after 9 Gy, 6 out of 10 after 12 Gy and 9 out of 10 after 15 Gy. Measuring c-myc expression seems to be a potential very early indicator of late radiation damage of kidney.

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  • THE EXPRESSION AND ENHANCEMENT OF CO-STIMULATORY MOLECULE (B7-1, B7-2) IN GASTRO-INTESTINAL CANCER.

    Grant number：08671377  1996 - 1997

    Japan Society for the Promotion of Science  Grants-in-Aid for Scientific Research  Grant-in-Aid for Scientific Research (C)

    HARAGUCHI Masaru, HATAKENAKA Masamitsu, YAMAGATA Motoyuki

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    Grant amount：\2200000 （ Direct Cost: \2200000 ）

    The co-stimulatory molecule (B7-1, B7-2) has been shown to play an important role in the induction of T cell mediated immunity against tumors. In the present study, we examined the expression of B7-1 and B7-2 in the human esophageal, gastric and colon cancer cell lines for mRNA level by a reverse transcriptase/polymerase chain reaction analysis (RT-PCR), for their surface expression by a flow-cytometric analysis with monoclonal antibodies. The expression of mRNA for B7-1 or B7-2 was detected in all 18 cell lines tested, except for B7-2 on one cell line. The cells from 13 (72%) or 12 (67%) of these cell lines expressed the surface B7-1 or B7-2 antigen, detected with respective mAb. The surface expression of B7-1 or B7-2 was increased in four to five of the six cell lines tested after a culture with interferon-gamma (IFN-g). In addition, the up-regulation of B7-1 or B7-2 expression by IFN-g was inhibited by interleukin-10 (IL-10). These results indicated that, in the cell lines derived from gastrointestinal carcinoma, both the co-stimulatory molecules B7-1 and B7-2 were detectable in the majority of the cell lines examined at the mRNA and protein levels, and could be regulated with cytokine IFN-g and IL-10.

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  • Association between genetic polymorphism and susceptibility to gastrointestinal cancers.

    Grant number：08671458  1996 - 1997

    Japan Society for the Promotion of Science  Grants-in-Aid for Scientific Research  Grant-in-Aid for Scientific Research (C)

    YOSHIKAWA Yasuji, HATAKENAKA Masamitsu, HARAGUCHI Masaru, MORI Nasaki

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    Grant amount：\2300000 （ Direct Cost: \2300000 ）

    L-myc polymorphism has been documented to be a representative genetic trait which implicates an individualls susceptibility to several cancers. However, no reports concerning any significant association between gastrointestinal canars such as esophgeal cancer, gastric cancer and colon cancer and L-myc polymorphism have been found. We analyzed the distribution of L-myc polymorphism in Japanese patients with gastrointestinal cancer by a molecular genotyping method using polymerase chain reaction-based restriction fragment length polymorphism ( PCR-RFLP). Based on an analysis of 61 gastric cancer patients, 50 esophageal cancer patients, and 107 healthy control subjects, there was a significant difference in either the distribution of genotypes (p=0.024 in gastric cancer, p=0.009 in esophageal cancer) between the respective cancer group and healthy control group. Furthermore, the relative risk of gastric cancer for genotypes having the shorter allele was 3.09 in gastric cancer, 5.29 in esophageal cancer compared to the longer allele homozygote. No significant difference in their distribution was found based on the clinicopathological features of the cancers. These results suggest that L-myc polymorphism may play a significant role for an individuals susceptibility to Japanese gastric cancer and esophageal cancer, and may be a useful marker for predicting the high-risk groups of gastric cancer and esophageal cancer. In colon cancer group, there was no significant difference with control group in the distribution of the genotype.

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  • 骨格筋筋線維分化と緩和時間との関係の解明

    Grant number：08770735  1996

    文部科学省  科学研究費補助金(奨励研究(A))  奨励研究(A)

    畠中 正光

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    Authorship：Principal investigator  Grant type：Competitive

    Grant amount：\900000 （ Direct Cost: \900000 ）

    実験動物はウサギを用い、ペントバルビタールにて麻酔下に実験を行った。MRI装置はGE社製Signa Advantage 1.5Tを用い、Extremity coilを使用した。目的とする筋肉の位置決め後、T1緩和時間の計測にはInversion Recovery系列を、T2緩和時間の計測にはSpin Echo系列を用いた。Inversion Recovery系列ではT1時間を6種類、Spin Echo系列ではTE時間を6種類変化させて得られたdata pointsからNon linear regressionによってパラメーターの推定を行いT1,T2緩和時間を計算した。slow twitch muscleとしては、soleusを、fast twitch muscleとしてはgastrocnemiusおよびextensor digitorum longusを選定した。T2緩和時間に関してはslow twitch muscleの値の方が大きいとの結果が出ているが、実験数が十分でなく結論には至っていない。今後実験数を増やしより正確に評価していく予定である。緩和時間の差の原因に関しては、slow twitch muscleでは筋小胞体構造が発達し細胞外液の割合が高いためとする意見(Polak.J.F.Investigative Radiology)があるが、この説が正しいとするT1,T2緩和時間ともにslow twitch muscleの値の方が大きくなると考えらえ、研究結果と矛盾し説明することはできない。原因に関しては、血流、筋小胞体構造、収縮関連蛋白アイソホーム等との関連について現在研究を進めている。

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  • Diagnostic radiology using MRI

    1995 - 2002

    Grant-in-Aid for Scientific Research 

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    Grant type：Competitive

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  • MR画像から計算したconductivity値に基づく直腸がん悪性度評価方法確立

    日本学術振興会  基盤研究（C) 

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