Details of a Researcher - HATAKENAKA Masamitsu

Papers - HATAKENAKA Masamitsu

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Diagnosis of prosthetic joint infection at the hip using the standard uptake value of three-phase 99mTc-hydroxymethylene diphosphonate SPECT/CT

Naoya Yama, Satoshi Nagoya, Shintaro Sugita, Masayuki Koyama, Masamitsu Hatakenaka

Annals of Nuclear Medicine ( Springer Science and Business Media LLC ) 2022.04

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Chie Tsuruta, Kenji Hirata, Kohsuke Kudo, Naoya Masumori, Masamitsu Hatakenaka

European Radiology Experimental ( Springer Science and Business Media LLC ) 6 ( 1 ) 2022.03

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Abnormal [18F]fluorodeoxyglucose accumulation to tori tubarius in IgG4-related disease

Ken Nagahata, Masatoshi Kanda, Ryuta Kamekura, Masanari Sugawara, Naoya Yama, Chisako Suzuki, Kenichi Takano, Masamitsu Hatakenaka, Hiroki Takahashi

Annals of Nuclear Medicine ( Springer Science and Business Media LLC ) 36 ( 2 ) 200 - 207 2022.02 [Domestic journal]

OBJECTIVES: Tubarial glands (TGs) are recently refocused gland tissues localized near the tori tubarius in the nasopharynx and their clinical relevance is not clear yet. IgG4-related disease (IgG4-RD) is a progressive fibrosing condition and salivary glands are well-affected lesions. The aim of the present study is to examine [18F]fluorodeoxyglucose ([18F]FDG) accumulation to the tori tubarius in IgG4-related disease (IgG4-RD). METHODS: 48 patients with IgG4-RD who underwent positron emission tomography (PET) scanning with [18F]FDG were included and semi-quantitative analysis of [18F]FDG accumulation to tori tubarius was performed along with the clinical features and histopathological analysis. RESULTS: Of the 48 patients, abnormal [18F]FDG accumulation (metabolic tumour volume ≥ 1) to tori tubarius was observed in 15 (31.3%), all of whom had lesions in other head and neck glands. IgG4-RD patients with abnormal [18F]FDG accumulation to tori tubarius showed swollen nasopharyngeal walls around tori tubarius and forceps biopsy of the lesion revealed acinar cells and IgG4-positive plasma cells histologically. Abnormal [18F]FDG accumulation (maximum standard uptake value, metabolic tumour volume and total lesion glycolysis) to tori tubarius correlated with higher IgG4 and lower IgA serum concentrations. CONCLUSIONS: Abnormal [18F]FDG accumulation to tori tubarius can be observed in patients with IgG4-RD and the abnormal [18F]FDG accumulation to tori tubarius can be a clue of TG involvement in IgG4-RD.

DOI PubMed

MRI-detected extramural vascular invasion potentiates the risk for pathological metastasis to the lateral lymph nodes in rectal cancer.

Atsushi Hamabe, Masayuki Ishii, Koichi Onodera, Kenji Okita, Toshihiko Nishidate, Koichi Okuya, Emi Akizuki, Ryo Miura, Takahiro Korai, Masamitsu Hatakenaka, Ichiro Takemasa

Surgery today 2021.03 [Domestic journal]

PURPOSE: Multidisciplinary treatment for locally advanced rectal cancer requires an accurate assessment of the risk of metastasis to the lateral lymph nodes (LNs). We herein aimed to stratify the risk of pathological metastasis to lateral LNs based on the preoperatively detected malignant features. METHODS: All patients with rectal cancer who underwent surgery from January 2016 to July 2020 were identified. We recorded the TNM factors; perirectal and lateral LN sizes; and MRI findings, including mesorectal fascia involvement, extramural vascular invasion (EMVI), tumor site, and tumor distance from the anal verge. RESULTS: 101 patients underwent rectal resection with lateral lymph node dissection, of whom 16 (15.8%) exhibited pathological metastases to the lateral LNs. Univariate analyses demonstrated that lateral LN metastasis was significantly correlated with mrEMVI positivity (p = 0.0023) and a baseline lateral LN short-axis length of ≥ 5 mm (p < 0.0001). These significant associations were confirmed by a multivariate analysis (p = 0.0254 and 0.0027, respectively). The lateral LN metastasis rate was as high as 44% in cases bearing both risk factors, compared to 0% in cases lacking both risk factors. CONCLUSION: The results elucidated in this study may contribute to risk stratification, which can be used when determining the indications for lateral lymph node dissection.

DOI PubMed

CT reconstruction with thick slices not only underestimates lymph node size but also reduces data reproducibility in colorectal cancer.

Yurina Onuma, Chie Tsuruta, Kenji Okita, Atsushi Hamabe, Keishi Ogura, Ichiro Takemasa, Masamitsu Hatakenaka

Acta radiologica (Stockholm, Sweden : 1987) 284185120968569 - 284185120968569 2020.10 [International journal]

BACKGROUND: Reliable size measurement of lymph node (LN) metastases is important for the evaluation of cancer treatment. However, image analyses without proper settings may result in inappropriate diagnoses and staging. PURPOSE: To investigate whether reconstruction slice thickness in computed tomography (CT) affects measurements of LN size and reproducibility. MATERIAL AND METHODS: We analyzed 48 patients with histological diagnoses of sigmoid colon and rectal cancer who underwent contrast-enhanced CT colonography as part of a surgical treatment preparation. A board-certified radiologist selected 106 LNs whose short-axis diameter was ≥5 mm on 1-mm-thick images; the short-axis diameters were measured on 1- and 5-mm-thick images by the radiologist and residents and compared using Wilcoxon matched-pairs signed rank test. Data variation and reproducibility were evaluated using the F test and Bland-Altman analysis. P<0.05 was considered significant. RESULTS: Short-axis diameters measured on 5-mm-thick images were significantly lower than those measured on 1-mm-thick images (P<0.01), even in the LNs whose short-axis diameters were over twice the slice thickness (P<0.05). Of the 106 LNs, 57 showed short-axis diameter <5 mm on 5-mm-thick images; the maximum short-axis diameter was 6.7 mm on a 1-mm thick image. Data variation was significantly larger on 5-mm thick images than 1-mm-thick images in small LNs (P<0.05) and reproducibility on 5-mm-thick images was inferior to that on 1-mm-thick images. CONCLUSION: Thick reconstruction slices in CT can result in an underestimation of LN size and reduce data reproducibility. When measuring LN size, a thin reconstruction slice would be recommended based on targeted LN size.

DOI PubMed

Lateral Position With Gantry Tilt Further Improves Computed Tomography Image Quality Reconstructed Using Single-Energy Metal Artifact Reduction Algorithm in the Oral Cavity

Maki Onodera, Kazunori Aratani, Takaharu Shonai, Keishi Ogura, Ken-ichi Kamo, Kazuhiro Ogi, Atsushi Kondo, Masamitsu Hatakenaka

Journal of Computer Assisted Tomography ( Ovid Technologies (Wolters Kluwer Health) ) 44 ( 4 ) 553 - 558 2020.07

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Spatial resolution of CT

Masamitsu Hatakenaka

European Journal of Surgical Oncology ( Elsevier BV ) 45 ( 9 ) 1748 - 1748 2019.09

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Optimizing T1rho and T2 Values for Intervertebral Discs Obtained from the Combined T1rho and T2 Sequence

Imamura Rui, Takashima Hiroyuki, Nakanishi Mitsuhiro, Akatsuka Yoshihiro, Nagahama Hiroshi, Okuaki Tomoyuki, Yoneyama Masami, Hatakenaka Masamitsu

APPLIED MAGNETIC RESONANCE ( SPRINGER WIEN ) 50 ( 8 ) 959 - 966 2019.08 [Refereed]

To investigate the effect of the number of spin-lock (SL) and T2 preparation pulse using T1rho and T2 values obtained from the combined T1rho and T2 sequence. We included 30 patients who underwent magnetic resonance imagingof the lumbar spine because of low back pain and leg numbness, tingling, and pain. We used 3D turbo-field echo and the adiabatic pulse as SL pulse for T1rho mapping and the block pulse as T2 preparation pulse for T2 mapping of the combined T1rho and T2 sequence. The preparation time of T1rho and T2 was set at 0, 20, 40, 60, and 80ms. We defined the T1rho and T2 values calculated from all SL and T2 preparation pulses as Dfull and decreased several number of SL and T2 preparation pulses from Dfull as other groups (D1, D2, and D3). We used the Bland-Altman analyses to estimate the systematic and proportional bias between Dfull and other groups. The 95% CI of the mean difference included zero in all groups. Therefore, systematic bias was not detected. The regression coefficients with D3 of the T1rho and T2 value were -0.34 and -0.23, respectively (p<0.01). We detected the proportional bias in the T1rho and T2 values in only D3 (0 and 80ms). An investigation of the T1rho and T2 values of IVDs using the combined T1rho and T2 sequence suggested that the accuracy of these values decreased with suitably adjusted three preparation pulses, facilitating the assessment of both T1rho and T2 values at approximately 10min.

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Optimization of MR Signal Contrast of the Lumbar Cartilaginous Endplates Using Ultra-Short TE

Hiroyuki Takashima, Mika Yanagida, Rui Imamura, Mitsunori Yoshimoto, Izaya Ogon, Mitsuhiro Nakanishi, Yoshihiro Akatsuka, Tomoyuki Okuaki, Masami Yoneyama, Masamitsu Hatakenaka, Toshihiko Yamashita

APPLIED MAGNETIC RESONANCE ( SPRINGER WIEN ) 50 ( 1-3 ) 381 - 389 2019.03

The ultra-short TE (UTE) technique has been recently used to investigate lumbar cartilaginous endplates (CEPs). However, parameters of UTE have not been investigated, especially optimal second TE is unclear. The aim of this study was to investigate the use of an optimal second TE with UTE for visualizing CEPs. The subjects included 20 volunteers without LBP who did not undergo lumbar spine surgery. A UTE sequence with fat suppression was used, and TEs were set at 0.16ms as first TE, and 4.6, 9.2, 13.8, 18.2ms as second TE. Analyzed images subtracted each second TE image from first TE image. Two researchers measured contrast ratio (CR) between CEPs and vertebral bodies (VBs), intervertebral discs (IVDs). ICCs between two researchers were calculated for CRs (r=0.924, 0.939). CR between CEP and VB of 13.8 and 18.4ms was significantly higher than that of other TEs (p<0.01). CR between CEP and IVD of 9.2 and 13.8ms was significantly higher than that of other TEs (p<0.01, 0.05). CEPs were evaluated using subtraction images obtained with UTE. The first TE was 0.16ms, the optimal second TE was suggested to be 13.8ms for evaluating human CEPs.

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Clinical utility of 18F-fluorodeoxyglucose/positron emission tomography in diagnosis of immunoglobulin G4–related sclerosing sialadenitis

Kenichi Takano, Ryoto Yajima, Ryuta Kamekura, Motohisa Yamamoto, Hiroki Takahashi, Naoya Yama, Masamitsu Hatakenaka, Tetsuo Himi

Laryngoscope ( John Wiley and Sons Inc. ) 128 ( 5 ) 1120 - 1125 2018.05 [Refereed]

Objectives/Hypothesis: The aim of this study was to evaluate the utility of 18F-fluorodeoxyglucose (FDG) positron emission tomography/computed tomography (PET/CT) for accurately diagnosing immunoglobulin G4-related sclerosing sialadenitis (IgG4-SS). Study Design: Retrospective cohort study. Methods: We reviewed the records of 64 patients with IgG4-SS (35 male and 29 female patients) and 10 patients with clinically suspected IgG4-SS. Pathological diagnoses of patients clinically suspected with IgG4-SS included four cases of malignant lymphoma, one case of multicentric Castleman disease, one case of Sjögren's syndrome, and four cases of sialadenitis. All patients underwent submandibular gland (SMG) biopsies and baseline FDG-PET/CT evaluation. Clinical, serological, pathological, and PET/CT findings were analyzed. We also investigated maximum standardized uptake values (SUVmax) in the salivary glands of 15 patients with malignant disease of the salivary glands during the same period. Results: Increased FDG uptake in the SMG and parotid gland was found in 63 (98%) and 23 (35%) patients with IgG4-SS, respectively. FDG uptake of the bilateral SMG and unilateral SMG was recorded in 57 patients (89%) and six patients (9%), respectively. Mean SUVmax in patients with malignant disease of the salivary glands was significantly higher than that in patients with IgG4-SS (P =.035). We defined a positive test for IgG4-SS diagnosis as high SMG FDG uptake and serum IgG4 level ≥135 mg/dL, resulting in a sensitivity, specificity, and accuracy of 96.9%, 90.0%, and 86.4%, respectively. Conclusions: FDG-PET/CT findings in combination with serological and clinical findings may have the capacity to diagnose IgG4-SS and lead to less-invasive biopsy procedures. Level of Evidence: 4. Laryngoscope, 128:1120–1125, 2018.

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Repeatability analysis of ADC histogram metrics of the uterus.

Onodera K, Hatakenaka M, Yama N, Onodera M, Saito T, Kwee TC, Takahara T

Acta Radiol. 2018.01 [Refereed]

Three cases of implantation of a SureScan(A (R)) system and MRI for investigating causes of pain

Kazunobu Takahashi, Atsushi Sawada, Soshi Iwasaki, Naoya Yama, Hiroyuki Takashima, Maki Onodera, Masamitsu Hatakenaka, Michiaki Yamakage

JOURNAL OF ANESTHESIA ( SPRINGER JAPAN KK ) 31 ( 6 ) 915 - 917 2017.12 [Refereed]

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Improvement in automated quantitation of myocardial perfusion abnormality by using iterative reconstruction image in combination with resolution recovery, attenuation and scatter corrections for the detection of coronary artery disease

Taiki Chono, Masahisa Onoguchi, Takayuki Shibutani, Akiyoshi Hashimoto, Tomoaki Nakata, Naoya Yama, Kazufumi Tsuchihashi, Masamitsu Hatakenaka

ANNALS OF NUCLEAR MEDICINE ( SPRINGER ) 31 ( 2 ) 181 - 189 2017.02 [Refereed]

An iterative reconstruction method in combination with resolution recovery, attenuation and scatter corrections (IR-RASC) can improve image quality. It, however, is undetermined whether this technique can improve the detection of coronary artery disease (CAD) when automated quantitative analysis is used. This study evaluated diagnostic values of IR-RASC in combination with automated quantitative analysis in stress myocardial perfusion imaging (MPI) in the CAD detection. This study enrolled consecutive 64 patients (mean age 66.2 +/- 17.3 years, 39 males) who had undergone both Tc-99m-labeled tetrofosmin stress MPI and coronary angiography within 3 months. Stress MPI abnormalities quantified as summed stress score (SSS), summed rest score (SRS) and summed difference score (SDS) by Heart Risk View-S (HRV-S) and Quantitative Perfusion SPECT (QPS) softwares using IR-RASC images were compared with those by using conventional filtered back-projection method (FBP) images and angiographic findings. Based on expert visual assessment, SSS and SRS by HRV-S/QPS softwares with IR-RASC were significantly lower than those by HRV-S/QPS softwares with FBP at mid- and basal left ventricular segments. Receiver-operating characteristics analysis showed that areas under the curve assessed by HRV-S (0.687) and QPS (0.678) with IR-RASC were nearly identical to those (0.717-0.724) by expert assessment with FBP, and were significantly (P < 0.05) greater than those by HRV-S (0.505) and QPS (0.522) with FBP. When HRV-S was used, the specificity and diagnostic accuracy of IR-RASC in the CAD detection were significantly greater than those of FBP: 90.3 versus 51.6%, P < 0.0001 and 79.7 versus 54.7%, P = 0.0027, respectively. Likewise, when QPS was used, the specificity and diagnostic accuracy of IR-RASC in the CAD detection were significantly greater than those of FBP: 80.6 versus 41.9%, P < 0.0001, and 78.1 versus 51.6%, P = 0.0018, respectively. There, however, were no significant differences in sensitivity between IR-RASC and FBP images. IR-RASC can improve diagnostic accuracy of the CAD detection using an automated scoring system compared to FBP, by reducing false positivity due to artefactual appearance.

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Influence of the Different Primary Cancers and Different Types of Bone Metastasis on the Lesion-based Artificial Neural Network Value Calculated by a Computer-aided Diagnostic System, BONENAVI, on Bone Scintigraphy Images.

Isoda T, BaBa S, Maruoka Y, Kitamura Y, Tahara K, Sasaki M, Hatakenaka M, Honda H

Asia Ocean J Nucl Med Biol. 5 ( 1 ) 49 - 55 2017 [Refereed]

Balanced MR cholangiopancreatography with motion-sensitised driven-equilibrium (MSDE) preparation: feasibility of Gd-EOB-DTPA-enhanced biliary examination

T. Nakayama, T. Yoshiura, A. Nishie, Y. Asayama, K. Ishigami, D. Kakihara, Y. Takayama, M. Hatakenaka, M. Obara, H. Honda

CLINICAL RADIOLOGY ( W B SAUNDERS CO LTD ) 71 ( 12 ) 1284 - 1288 2016.12 [Refereed]

AIM: To evaluate the effectiveness of motion-sensitised driven-equilibrium (MSDE)-prepared balanced magnetic resonance cholangiopancreatography (MRCP) in a gadolinium ethoxybenzyl diethylene triamine pentaacetic acid (Gd-EOB-DTPA)-enhanced study compared to conventional T2-weighted MRCP. MATERIALS AND METHODS: Fifteen patients (seven male and eight female patients) prospectively underwent conventional three-dimensional turbo spin-echo T2-weighted MRCP and MSDE-balanced MRCP using a 1.5 T MRI system after hepatobiliary phase image acquisition. For quantitative evaluation, the contrast-to-noise ratio (CNR) of the common hepatic duct to liver tissue was calculated. For qualitative analysis, two radiologists evaluated the depiction of the biliary system and main pancreatic duct (MPD) using a scoring system. Signal suppression of the portal vein (PV) and hepatic vein (HV) on MSDE-balanced MRCP was also scored. RESULTS: MSDE-balanced MRCP showed significantly higher CNR than T2-weighted MRCP. For all biliary structures, the mean depiction scores of MSDE-balanced MRCP were significantly higher than those of T2-weighted MRCP, whereas the mean depiction score of MPD with MSDE-balanced MRCP was significantly lower than that of T2-weighted MRCP. Signal suppression of the PV and HV was thought to be clinically sufficient. CONCLUSIONS: MSDE-balanced MRCP more clearly depicted biliary structures compared with T2-weighted MRCP in a Gd-EOB-DTPA-enhanced study. This sequence may be utilised for routine MRCP on Gd-EOB-DTPA-enhanced MRI. (C) 2016 The Royal College of Radiologists. Published by Elsevier Ltd. All rights reserved.

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The signal intensity ratio of the optic nerve to ipsilateral frontal white matter is of value in the diagnosis of acute optic neuritis

Maki Onodera, Naoya Yama, Masato Hashimoto, Takaharu Shonai, Kazunori Aratani, Hiroyuki Takashima, Ken-ichi Kamo, Hiroshi Nagahama, Hiroshi Ohguro, Masamitsu Hatakenaka

EUROPEAN RADIOLOGY ( SPRINGER ) 26 ( 8 ) 2640 - 2645 2016.08 [Refereed]

To evaluate the usefulness of the signal intensity ratio (SIR) of the optic nerve to the white matter (WM) on short tau inversion recovery (STIR) images to diagnose acute optic neuritis (AON). The 405 consecutive patients with suspected orbital diseases underwent orbital magnetic resonance imaging (MRI) using a 3-T scanner between June 2008 and August 2011. Among them, 108 optic nerves (33 AON and 75 control) were retrospectively analysed. The averaged SIR (SIRave) and maximum SIR (SIRmax) were defined as the averaged signal intensity (SI) of the optic nerve divided by that of WM, and the maximum SI of the optic nerve divided by averaged SI of WM, respectively. These values were compared between AON and control using the Mann-Whitney U test. A P < 0.05 was considered statistically significant. SIRave and SIRmax were significantly (P < 0.001) higher in the AON compared to the control. At a cut-off SIRave value of 1.119, the sensitivity, specificity and accuracy were 0.939, 0.840, and 0.870; and at a cut-off SIRmax value of 1.281, these were 1.000, 0.720 and 0.806, respectively. The SIR of the optic nerve to WM on STIR images is of value in diagnosing AON. aEuro cent We propose a method of diagnosing acute optic neuritis using 3-T MRI. aEuro cent Our method is simple and objective and requires no novel imaging techniques. aEuro cent Our method shows high diagnostic accuracy.

DOI PubMed

Trials of vaccines for pancreatic ductal adenocarcinoma: Is there any hope of an improved prognosis?

Toru Mizuguchi, Toshihiko Torigoe, Fukino Satomi, Hiroaki Shima, Goro Kutomi, Shigenori Ota, Masayuki Ishii, Hiroshi Hayashi, Sumiyo Asakura, Yoshihiko Hirohashi, Makoto Meguro, Yasutoshi Kimura, Toshihiko Nishidate, Kenji Okita, Masaho Ishino, Atsushi Miyamoto, Masamitsu Hatakenaka, Noriyuki Sato, Koichi Hirata

SURGERY TODAY ( SPRINGER ) 46 ( 2 ) 139 - 148 2016.02 [Refereed]

Pancreatic tumors are chemoresistant and malignant, and there are very few therapeutic options for pancreatic cancer, as the disease is normally diagnosed at an advanced stage. Although attempts have been made to develop vaccine therapies for pancreatic cancer for a couple of decades, none of the resultant protocols or regimens have succeeded in improving the clinical outcomes of patients. We herein review vaccines tested within the past few years, including peptide, biological and multiple vaccines, and describe the three sets of criteria used to evaluate the therapeutic activity of vaccines in solid tumors.

DOI PubMed

Risk of node metastasis of sentinel lymph nodes detected in level II/III of the axilla by single-photon emission computed tomography/computed tomography

Hiroaki Shima, Goro Kutomi, Fukino Satomi, Hideki Maeda, Tomoko Takamaru, Hidekazu Kameshima, Tosei Omura, Mitsuru Mori, Masamitsu Hatakenaka, Tadashi Hasegawa, Koichi Hirata

EXPERIMENTAL AND THERAPEUTIC MEDICINE ( SPANDIDOS PUBL LTD ) 8 ( 5 ) 1447 - 1452 2014.11 [Refereed]

In breast cancer, single-photon emission computed tomography/computed tomography (SPECT/CT) shows the exact anatomical location of sentinel nodes (SN). SPECT/CT mainly exposes axilla and partly exposes atypical sites of extra-axillary lymphatic drainage. The mechanism of how the atypical hot nodes are involved in lymphatic metastasis was retrospectively investigated in the present study, particularly at the level II/III region. SPECT/CT was performed in 92 clinical stage 0-IIA breast cancer patients. Sentinel lymph nodes are depicted as hot nodes in SPECT/CT: Patients were divided into two groups: With or without hot node in level II/III on SPEC/CT. The existence of metastasis in level II/III was investigated and the risk factors were identified. A total of 12 patients were sentinel lymph node biopsy metastasis positive and axillary lymph node dissection (ALND) was performed. These patients were divided into two groups: With and without SN in level and nodes in level II/III were pathologically proven. In 11 of the 92 patients, hot nodes were detected in level There was a significant difference in node metastasis depending on whether there were hot nodes in level II/III (P=0.0319). Multivariate analysis indicated that the hot nodes in level II/III and lymphatic invasion were independent factors associated with node metastasis. There were 12 SN-positive patients followed by ALND. In four of the 12 patients, hot nodes were observed in level Two of the four patients with hot nodes depicted by SPECT/CT and metastatic nodes were pathologically evident in the same lesion. Therefore, the present study indicated that the hot node in level II/III as depicted by SPECT/CT may be a risk of SN metastasis, including deeper nodes.

DOI PubMed

Many Methods of Mediastinal Division

Satoru Yoshida, Masamitsu Hatakenaka

RADIOLOGY ( RADIOLOGICAL SOC NORTH AMERICA ) 272 ( 1 ) 302 - 303 2014.07 [Refereed]

DOI PubMed

Quantitative Analysis of 1.5-T Whole-Heart Coronary MR Angiograms Obtained with 32-Channel Cardiac Coils: A Comparison with Conventional Quantitative Coronary Angiography

Masato Yonezawa, Motonori Nagata, Kakuya Kitagawa, Shingo Kato, Yeonyee Yoon, Hiroshi Nakajima, Shiro Nakamori, Hajime Sakuma, Masamitsu Hatakenaka, Hiroshi Honda

RADIOLOGY ( RADIOLOGICAL SOC NORTH AMERICA ) 271 ( 2 ) 356 - 364 2014.05 [Refereed]

Purpose: To develop a method to determine significant stenosis at whole-heart coronary magnetic resonance (MR) angiography and to evaluate the accuracy and reproducibility of this approach.Materials and Methods: The institutional review board approved the study, and all participants provided written informed consent. Sixty-two patients who were suspected of having coronary artery disease (CAD) and were scheduled for conventional coronary angiography were included. Coronary MR angiography was performed by using a 1.5-T imager with 32-channel coils. Luminal narrowing was evaluated with quantitative analysis (QA) of coronary MR angiograms on the basis of the signal intensity profile along the vessel. Percentage stenosis with QA of coronary MR angiograms was calculated as [1 - (SImin/SIref)] Chi 100, where SImin is minimal signal intensity and SIref is corresponding reference signal intensity. Diagnostic performance of QA of coronary MR angiograms for predicting at least a 50% reduction in diameter was evaluated by using quantitative coronary angiography (QCA), with conventional angiography findings serving as the reference standard. Receiver operating characteristic (ROC) analysis, Spearman rank correlation, Bland-Altman analysis, and Cohen k analysis were used.Results: The areas under the ROC curve in a segment-based analysis for detecting significant CAD were 0.96 (95% confidence interval [CI]: 0.94, 0.98) with QA of coronary MR angiograms and 0.93 (95% CI: 0.88, 0.98) with visual assessment. The correlation coefficients between percentage stenosis with QA of coronary MR angiograms and percentage stenosis with QCA were 0.84 (P < .001), 0.80 (P < .001), and 0.66 (P < .001) in the patient-, vessel-, and segment-based analyses, respectively.Conclusion: QA of coronary MR angiograms with use of a signal intensity profile along the vessel permits detection of CAD. This method had a diagnostic performance approximately equal to that of visual analysis of coronary MR angiograms with high inter-and intraobserver reliability, allowing for more objective interpretation of coronary MR angiography findings. (C) RSNA, 2013

DOI PubMed

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Papers - HATAKENAKA Masamitsu