Details of a Researcher - HATAKENAKA Masamitsu

Papers - HATAKENAKA Masamitsu

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Computed tomographic and magnetic resonance features of inflammatory myofibroblastic tumor of the lung in children

Yukihisa Takayama, Hidetake Yabuuchi, Yoshio Matsuo, Hiroyasu Soeda, Takashi Okafuji, Takeshi Kamitani, Yoshiaki Kinoshita, Naoya Kubokura, Shuji Sakai, Yoshinao Oda, Masamitsu Hatakenaka, Hiroshi Honda

Radiation Medicine - Medical Imaging and Radiation Oncology ( 10 ) 26 ( 10 ) 613 - 617 2008.12 [Refereed]

We report two cases of inflammatory myofibroblastic tumor (IMT) of the lung in a 4-year-old boy and a 7-year-old girl. We performed dynamic contrastenhancement computed tomography in both of our cases and dynamic contrast enhancement magnetic resonance imaging (MRI) in one case. These dynamic studies showed a demarcated mass with delayed enhancement in both cases. A T1-weighted MR image shows a mass with homogeneous low signal intensity, and a T2- weighted image shows a mass with slightly high signal intensity. A post-contrast-enhanced T1-weighted image demonstrates homogeneous enhancement. We speculate that the delayed enhancement could be attributed to the abundant fibrous tissue, which was the main structural material of the tumor. This same finding has been described in previous reports of IMT in other organs. © 2008 Japan Radiological Society.

Parotid Gland Tumors: Can Addition of Diffusion-weighted MR Imaging to Dynamic Contrast-enhanced MR Imaging Improve Diagnostic Accuracy in Characterization?

Hidetake Yabuuchi, Yoshio Matsuo, Takeshi Kamitani, Taro Setoguchi, Takashi Okafuji, Hiroyasu Soeda, Shuji Sakai, Masamitsu Hatakenaka, Torahiko Nakashima, Yoshinao Oda, Hiroshi Honda

RADIOLOGY ( RADIOLOGICAL SOC NORTH AMERICA ) 249 ( 3 ) 909 - 916 2008.12 [Refereed]

Purpose: To determine the value of adding diffusion-weighted (DW) magnetic resonance (MR) imaging to dynamic contrast material-enhanced MR imaging when distinguishing between benign and malignant parotid tumors. Materials and Methods: This retrospective study was approved by the institutional review board, and the informed consent requirement was waived. The authors analyzed MR images of 50 lesions ( 36 benign, 14 malignant) in 47 patients. DW MR imaging and dynamic contrast-enhanced MR imaging were performed in all patients. Time-intensity curve ( TIC) patterns were categorized as follows: type A, time to peak was more than 120 seconds; type B, time to peak was 120 seconds or less with high washout ratio (>= 30%); type C, time to peak was 120 seconds or less with low washout ratio (< 30%); and type D, flat. The apparent diffusion coefficient ( ADC) values were measured on DW MR images. Sensitivity, specificity, accuracy, and positive and negative predictive values were calculated for type A, B, and D tumors regarded as benign and for type C tumors regarded as malignant. On the basis of DW MR imaging results, ADC threshold values between pleomorphic adenomas and carcinomas and between Warthin tumors and carcinomas were selected. Diagnostic accuracy was compared before and after modification diagnosis referring to the ADC value obtained with the McNemar test. P < .05 was considered to indicate a significant difference. Results: ADC threshold values were 1.4 x 10(-3) mm(2)/sec between pleomorphic adenomas and carcinomas and 1.0 x 10(-3) mm2/sec between Warthin tumors and carcinomas. Accuracy (82% vs 94%) and positive predictive value (67% vs 92%) significantly improved with the addition of ADC values in the evaluation of patients with type B or C tumors. Conclusion: A persistent or flat TIC pattern on dynamic contrast-enhanced MR images indicates benign disease, but there is added value from including the ADC value in the evaluation of tumors that show a plateau or washout TIC pattern. (C) RSNA, 2008

Computed tomographic and magnetic resonance features of inflammatory myofibroblastic tumor of the lung in children

Yukihisa Takayama, Hidetake Yabuuchi, Yoshio Matsuo, Hiroyasu Soeda, Takashi Okafuji, Takeshi Kamitani, Yoshiaki Kinoshita, Naoya Kubokura, Shuji Sakai, Yoshinao Oda, Masamitsu Hatakenaka, Hiroshi Honda

RADIATION MEDICINE ( SPRINGER ) 26 ( 10 ) 613 - 617 2008.12 [Refereed]

We report two cases of inflammatory myofibroblastic tumor (IMT) of the lung in a 4-year-old boy and a 7-year-old girl. We performed dynamic contrastenhancement computed tomography in both of our cases and dynamic contrast enhancement magnetic resonance imaging (MRI) in one case. These dynamic studies showed a demarcated mass with delayed enhancement in both cases. A T1-weighted MR image shows a mass with homogeneous low signal intensity, and a T2- weighted image shows a mass with slightly high signal intensity. A post-contrast-enhanced T1-weighted image demonstrates homogeneous enhancement. We speculate that the delayed enhancement could be attributed to the abundant fibrous tissue, which was the main structural material of the tumor. This same finding has been described in previous reports of IMT in other organs.

Enhanced Mass on Contrast-Enhanced Breast MR Imaging: Lesion Characterization Using Combination of Dynamic Contrast-Enhanced and Diffusion-Weighted MR Images

Hidetake Yabuuchi, Yoshio Matsuo, Takashi Okafuji, Takeshi Kamitani, Hiroyasu Soeda, Taro Setoguchi, Shuji Sakai, Masamitsu Hatakenaka, Makoto Kubo, Noriaki Sadanaga, Hidetaka Yamamoto, Hiroshi Honda

JOURNAL OF MAGNETIC RESONANCE IMAGING ( JOHN WILEY & SONS INC ) 28 ( 5 ) 1157 - 1165 2008.11 [Refereed]

Purpose: To evaluate the diagnostic accuracy of a combination of dynamic contrast-enhanced MR imaging (DCE-MRI) and diffusion-weighted MR imaging (DWI) in characterization of enhanced mass on breast MR imaging and to find the strongest discriminators between carcinoma and benignancy. Materials and Methods: We analyzed consecutive breast MR images in 270 patients; however, 13 lesions in 93 patients were excluded based on our criteria. We analyzed tumor size, shape, margin, internal mass enhancement, kinetic curve pattern, and apparent diffusion coefficient (ADC) values. We applied univariate and multivariate analyses to find the strongest indicators of malignancy and calculate a predictive probability for malignancy. We added the corresponding categories to these prediction probabilities for malignancy and calculated diagnostic accuracy when we consider category 4b, 4c, and 5 lesions as malignant and category 4a. 3. and 2 lesions as benign. In a validation study, 75 enhancing lesions In 71 patients were examined consecutively. Results: Irregular margin, heterogeneous internal enhancement, rim enhancement, plateau time-intensity curve (TIC) pattern, and washout TIC pattern were the strongest indicators of malignancy as well as past studies, and ADC values less than 1.1 X 10(-3) mm(2)/S were also the strongest indicators of malignancy. In a validation study, sensitivity, specificity, positive predictive value, negative predictive value, and accuracy were 92% (56/61), 86% (12/14), 97% (56/58), 71% (12/17), and 91% (68/75), respectively. Conclusion: The combination of DWI and DCE-MRI could produce high diagnostic accuracy in the characterization of enhanced mass on breast MR Imaging.

Optimal gradation processing parameter for soft-copy reading of digital mammogram: Comparison between the parameter recommended for hard-copy and other parameters

Takeshi Kamitani, Hidetake Yabuuchi, Hiroyasu Soeda, Yoshio Matsuo, Takashi Okafuji, Taro Setoguchi, Shuji Sakai, Masamitsu Hatakenaka, Nobuhide Ishii, Hiroshi Honda

EUROPEAN JOURNAL OF RADIOLOGY ( ELSEVIER IRELAND LTD ) 66 ( 2 ) 309 - 312 2008.05 [Refereed]

Purpose: To investigate optimal gradation processing parameter for soft-copy reading comparing the parameter recommended for hard-copy with other parameters. Materials and methods: Digital mammograms using a Computed Radiography system were evaluated. The gradation processing parameter recommended by the manufacturer was GA (1.2). We prepared seven parameters that changed the degree of contrast: GA (0.6, 0.8, 1.0, 1.2, 1.4, 1.6, and 1.8). Images of an anthropomorphic breast phantom were displayed on a 5-megapixel liquid crystal display monitor using each parameter. Three readers independently assessed each image, and scored for the following items: intramammary contrast, extramammary contrast, sharpness, and graininess. Total score was calculated in each parameter. We also displayed normal mammograms of nine cases: three with a scattered fibroglandular density, three with a heterogeneously dense breast, and three with an extremely dense breast. These were displayed using GA (1.2) or using parameters with a higher total score than GA (1.2) in the phantom test. Three readers assessed each mammogram as in the phantom test. Results: In phantom test, GA (1.4), GA (1.6), and GA (1.8) obtained higher scores than GA (1.2). In normal cases tested using these parameters, GA (1.4) obtained the highest score. This was significantly higher than that of GA (1.2) (P = 0.004). The score obtained for GA (1.4) was the highest in cases with extremely dense and heterogeneously dense breast tissue, though there was no statistically significant difference. Conclusion: Soft-copy image quality was improved by gradient processing using higher contrast parameter than that routinely used in hard-copy, especially in dense breast cases. (C) 2007 Etsevier Ireland Ltd. All rights reserved.

Alteration of proton diffusivity associated with passive muscle extension and contraction

Masamitsu Hatakenaka, Yoshio Matsuo, Taro Setoguchi, Hidetake Yabuuchi, Takashi Okafuji, Takeshi Karnitani, Kei Nishikawa, Hiroshi Honda

JOURNAL OF MAGNETIC RESONANCE IMAGING ( JOHN WILEY & SONS INC ) 27 ( 4 ) 932 - 937 2008.04 [Refereed]

Purpose: To determine whether passive muscle extension and contraction affect the proton diffusivity of the muscle. Materials and Methods: Five male subjects were examined. The fractional anisotropy (FA), and primary (lambda(1)), secondary (lambda(2)), and tertiary eigenvalues (lambda(3)) of the right tibialis anterior and medial gastrocnemius muscles were compared between conditions of passive plantar flexion and passive dorsiflexion of the ankle joint. Results: In the tibialis anterior, FA, and lambda(1) at dorsiflexion decreased significantly (P < 0.01 and P < 0.01, respectively) compared to those at plantar flexion, but lambda(3) at dorsiflexion increased significantly (P = 0.02). In the gastrocnemius, FA and lambda(1) at dorsiflexion increased significantly (P < 0.0 1 and P < 0.0 1, respectively) compared to those at plantar flexion, but lambda(3) at dorsiflexion decreased significantly (P < 0.01). The lambda(2) value showed no significant change in either the tibialis anterior or medial gastrocnemius. Conclusion: The results indicate that passive muscle extension and contraction associated with passive joint movement would affect the proton diffusivity of the muscle. This alteration of proton diffusivity is probably associated with microscopic structural changes of the muscle.

Apparent diffusion coefficients of breast tumors: Clinical application

Masamitsu Hatakenaka, Hiroyasu Soeda, Hidetake Yabuuchi, Yoshio Matsuo, Takeshi Kamitani, Yoshinao Oda, Masazumi Tsuneyoshi, Hiroshi Honda

Magnetic Resonance in Medical Sciences ( 1 ) 7 ( 1 ) 23 - 29 2008 [Refereed]

Purpose: To evaluate the usefulness of apparent diffiusion coefficient (ADC) for the differential diagnosis of breast tumors and to determine the relation between ADC and tumor cellularity. Materials and Methods: One hundred and thirty-six female patients (age range, 17-83 years average age, 51.7 years) with 140 histologically proven breast tumors underwent diffusion-weighted magnetic resonance (MR) imaging (DWI) using the spin-echo echo-planar technique, and the ADCs of the tumors were calculated using 3 different b values, 0, 500, and 1000 s/mm2. The diagnoses consisted of fibroadenoma (FA, n=16), invasive ductal carcinoma, not otherwise specified (IDC, n=117), medullary carcinoma (ME, n=3) and mucinous carcinoma (MU, n=4). Tumor cellularity was calculated from surgical specimens. The ADCs of breast tumors and cellularity were compared between different histological types by analysis of variance and Scheffe's post hoc test. The correlation between tumor cellularity and ADC was analyzed by Pearson correlation test. Results: Significant differences were observed in ADCs between FA and all types of cancers (P< 0.05) and between MU and other types of cancers (P< 0.01) and in cellularity between FA and cancers except MU (P< 0.01) and between MU and other types of cancers (P< 0.01). There was an inverse correlation between ADC and tumor cellularity (P< 0.01, r2=0.451). Conclusions: The ADC may potentially help in differentiating benign and malignant breast tumors. Tumor ADC correlates inversely with tumor cellularity.

Circumscribed mass lesions on mammography: Dynamic contrast-enhanced MR imaging to differentiate malignancy and benignancy

Takashi Okafuji, Hidetake Yabuuchi, Hiroyasu Soeda, Yoshio Matsuo, Takeshi Kamitani, Shuji Sakai, Masamitsu Hatakenaka, Syoji Kuroki, Eriko Tokunaga, Hidetaka Yamamoto, Hiroshi Honda

Magnetic Resonance in Medical Sciences ( 4 ) 7 ( 4 ) 195 - 204 2008 [Refereed]

Purpose: We evaluated the magnetic resonance (MR) features of breast lesions showing circumscribed mass on mammography to understand the characteristics that differentiate malignancy and benignancy. Materials and Methods: Our institutional review board approved the study, and informed consent was waived. Using logistic regression analysis, we examined morphologic and kinetic MR imaging data of 90 breast lesions (43 malignant, 47 benign) that showed circumscribed mass on mammography. Results: Features identified as having high odds for malignancy included: rim enhancement (odds ratio, 70.894 95% confidence interval (CI), 7.525-667.938) heterogeneous enhancement (odds ratio, 10.839 95z CI, 1.032-113.856) and washout dynamic pattern (odds ratio, 46.262 95z CI, 3.716-575.901). Combinations of washout dynamic pattern and either rim or heterogeneous enhancement reflected excessively high prediction probability for malignancy (> 0.95), whereas combinations lacking washout dynamic pattern and with either homogeneous enhancement or dark internal septation revealed excessively low prediction probability for malignancy (< 0.05). Conclusion: Breast cancers with circumscribed mass on mammography could be differentiated from benign masses using internal enhancement and the kinetic pattern of contrast-enhanced breast MR imaging.

Effect of passive muscle length change on apparent diffusion coefficient: Detection with clinical MR imaging

Masamitsu Hatakenaka, Hidetake Yabuuchi, Yoshio Matsuo, Takashi Okafuji, Takeshi Kamitani, Taro Setoguchi, Kei Nishikawa, Hiroshi Honda

Magnetic Resonance in Medical Sciences ( 2 ) 7 ( 2 ) 59 - 63 2008 [Refereed]

Purpose: We investigated whether change in muscle microstructure associated with passive extension and contraction affects proton diffusivity. Material and Methods: In 6 male subjects, we compared apparent diffusion coefficients (ADC) along the posterior-to-anterior (ADC-PA), right-to-left (ADC-RL) and superior-to-inferior (ADC-SI) directions of the right tibialis anterior muscle with the ankle joint in passive plantar flexion and passive dorsiflexion. Results: Compared to the respective ADCs at plantar flexion, the ADC-PA (P=0.002) and ADC-RL (P=0.008) were significantly greater, but ADC-SI (P=0.008) significantly lower at dorsiflexion. Conclusion: Our results indicate that change in muscle microstructure associated with passive extension and contraction would affect proton diffusivity, and this alteration of proton diffusivity could be detected by measuring ADC with a clinical magnetic resonance scanner.

In vitro imaging of human monocytic cellular activity using superparamagnetic iron oxide

Akihiro Nishie, Kengo Yoshimitsu, Tomohiro Nakayama, Masamitsu Hatakenaka, Hiroyuki Irie, Yoshiyuki Shioyama, Shuji Matsuura, Yunosuke Nishihara, Koji Kobayashi, Hiroshi Honda

COMPUTERIZED MEDICAL IMAGING AND GRAPHICS ( PERGAMON-ELSEVIER SCIENCE LTD ) 31 ( 8 ) 638 - 642 2007.12 [Refereed]

The aim is to evaluate if a difference in activity of monocytic cells can be described on superparamagnetic iron oxide (SPIO)-magnetic resonance imaging (MRI) in vitro when a low concentration of SPIO is administered. Human monocytic cells were stimulated with phorbol 12-myristate 13-acetate (PMA) or left non-stimulated for 24 It and then treated with SPIO with a final concentration of 7.2 mu g Fe/ml for 48 h. They were collected, and an MRI phantom was prepared by suspending them in 4% gelatin and scanned using gradient-echo T2*-weighted and spin-echo T2-weighted imaging with two different echo times. The signal intensity and T2*/T2 relaxation times of each layer were also assessed. The number and degree of intracellular filling of cells positively stained with Berlin blue were evaluated microscopically. In addition, the heme oxygenase-1 expression in non-stimulated monocytic cells or monocytic cells stimulated with PMA was evaluated using semiquantitative reverse transcription and polymerase chain reaction. The signal reduction of cells stimulated with PMA was 3.9- to 5.0-fold and 2.7- to 3.1-fold greater than that of non-stimulated cells on the T2* and T2-weighted images, respectively. These signal reductions were also visually confirmed. Estimated T2*/T2 relaxation times of cells stimulated with PMA and non-stimulated cells were 31.3/137.8 and 122.8/182.6 ms, respectively. Cells positively stained with Berlin blue were observed in 4.5% and 25.3% of non-stimulated cells and those stimulated with PMA, respectively (p < 0.05). The intracellular filling in cells stimulated with PMA was significantly larger than that in non-stimulated cells (p < 0.05). The expression of the heme oxygenase-1 gene in monocytic cells stimulated with PMA was 2.9-fold greater than that in non-stimulated monocytic cells. SPIO-MRI can visually describe a difference in activity of monocytic cells in vitro when a low concentration of SPIO is administered. (c) 2007 Elsevier Ltd. All rights reserved.

Detection of masses and microcalcifications of breast cancer on digital mammograms: comparison among hard-copy film, 3-megapixel liquid crystal display (LCD) monitors and 5-megapixel LCD monitors: an observer performance study

Takeshi Kamitani, Hidetake Yabuuchi, Hiroyasu Soeda, Yoshio Matsuo, Takashi Okafuji, Shuji Sakai, Akio Furuya, Masamitsu Hatakenaka, Nobuhide Ishii, Hiroshi Honda

EUROPEAN RADIOLOGY ( SPRINGER ) 17 ( 5 ) 1365 - 1371 2007.05 [Refereed]

The purpose of the study was to compare observer performance in the detection of masses and microcalcifications of breast cancer among hard-copy reading and soft-copy readings using 3-megapixel (3M) and 5-megapixel (5M) liquid crystal display (LCD) monitors. For the microcalcification detection test, we prepared 100 mammograms: 40 surgically verified cancer cases and 60 normal cases. For the mass detection test, we prepared 100 mammograms: 50 cancer cases and 50 normal cases. After six readers assessed both microcalcifications and masses set for each modality, receiver operating characteristic (ROC) analysis was performed. The average A(z)s for mass detection using a hard copy and 3M and 5M LCD monitors were 0.923, 0.927 and 0.920, respectively; there were no significant differences. The average A(z) for microcalcification detection using hard copy, 3M and 5M LCD monitors was 0.977, 0.954 and 0.972, respectively. There were no significant differences, but the P-values between the hard copy and 3M LCD monitor and that between the 3M and 5M LCD monitor were 0.08 and 0.09, respectively. In conclusion, the observer performances for detecting masses of breast cancers were comparable among the hard copy and two LCD monitors; however, soft-copy reading with a 3M LCD monitor showed slightly lower observer performance for detecting microcalcifications of breast cancers than hard-copy or 5M LCD monitor reading.

Familial turner mosaicism 46XX/45XO with brain calcification [5]

Toyoki Maeda, Masahiro Sugano, Jing-Zhi Guan, Jun-Ichi Oyama, Yoshihiro Higuchi, Naoki Makino, Masamitsu Hatakenaka, Hiromi Muta, Masaharu Nakayama, Yukoh Nakazaki, Ryo Kurita, Takashi Hiroyama, Tomokazu Suzuki, Kenzaburo Tani

Journal of Neuropsychiatry and Clinical Neurosciences ( American Psychiatric Publishing Inc. ) 19 ( 3 ) 342 - 343 2007 [Refereed]

MR imaging features of pure mucinous carcinoma of the breast

Takashi Okafuji, Hidetake Yabuuchi, Shuji Sakai, Hiroyasu Soeda, Yoshio Matsuo, Takahiro Inoue, Masamitsu Hatakenaka, Naoki Takahashi, Syoji Kuroki, Eriko Tokunaga, Hiroshi Honda

EUROPEAN JOURNAL OF RADIOLOGY ( ELSEVIER IRELAND LTD ) 60 ( 3 ) 405 - 413 2006.12 [Refereed]

Objective: To characterize MR imaging features of pure mucinous carcinoma of the breast. Materials and methods: MR images obtained from 16 women (age range, 29-81; mean age, 57 years) with pure mucinous carcinoma of the breast determined at surgery were reviewed. The MR findings used were shape, margin, internal mass enhancement, kinetic curve pattern on dynamic study, signal intensity on short time inversion recovery (STIR) T2-weighted images, and non-mass-like enhancement around the main tumor. Non-mass-like enhancement was compared with the presence of extensive intraductal component (EIC) on histopathological findings. Results: Eleven tumors (69%) had lobular contour, and nine tumors (56%) had smooth margin. Eight tumors (50%) showed rim enhancement and six tumors (38%) showed heterogeneous enhancement. Fourteen tumors (88%) showed a persistent enhancing pattern on kinetic curve. Fifteen tumors exhibited homogenous strongly high signal intensity on STIR T2-weighted images. In six cases with EIC, five cases had non-mass-like enhancement around the main mass. Conclusions: MR findings such as lobular shape, rim or heterogeneous enhancement, persistent pattern on kinetic curve, and homogeneous strongly high signal intensity on STIR T2-weighted images may be useful in diagnosing pure mucinous carcinoma. Moreover, linear-ductal enhancement around main mass may indicate presence of EIC. (C) 2006 Elsevier Ireland Ltd. All rights reserved.

Phyllodes tumor of the breast: Correlation between MR findings and histologic grade

Hidelake Yabuuchi, Hiroyasu Soeda, Yoshio Matsuo, Takashi Okafuji, Takashi Eguchi, Shuji Sakai, Syoji Kuroki, Eriko Tokunaga, Shinji Ohno, Kenichi Nishiyama, Masamitsu Hatakenaka, Hiroshi Honda

RADIOLOGY ( RADIOLOGICAL SOC NORTH AMERICA ) 241 ( 3 ) 702 - 709 2006.12 [Refereed]

Purpose: To retrospectively evaluate the magnetic resonance (MR) aging findings of phyllodes tumor of the breast and to Uro, compare these findings with the histologic grade. Materials and Methods: Institutional review board approval and informed consent were obtained. The authors reviewed the MR findings in 30 female patients aged 16-73 years (mean, 40.2 years) with surgically confirmed phyllodes tumors. Analyzed MR findings included tumor, shape, margin, internal enhancement, and size; signal intensity (SI) of tumor higher than that of normal breast tissue on T1-weighted images; SI of tumor lower than or equal to that of normal tissue on T2-weighted images; cyst wall appearance; kinetic curve assessment; and apparent diffusion coefficient (ADC). The MR findings and histologic, grade were statistically analyzed to determine whether any correlations existed. Significant MR findings were compared with histopathologic findings. Results: Nineteen benign, six intermediate (characterized by five to nine cell reproductions at 10 high-power fields, pushing or infiltrative margins, moderate stromal cellularity, and atypia and overgrowth), and five malignant phyllodes tumors were assessed. Irregular cyst wall (P = .003), tumor SI lower than or equal to normal tissue SI on T2-weighted images (P = .005), and low ADC (P = .001) correlated significantly with histologic grade. Tumor SI higher than normal tissue SI on T1-weighted images was more frequent in the malignant (in three of five tumors) and inter mediate (in three of six tumors) groups than in the benign group (in two of 19 tumors); however, it was not a significant finding (P = .024). Tumor SI higher than normal tissue SI on T1-weighted images and irregular cyst wall corresponded histopathologically to hemorrhagic infarction and necrosis, respectively. Tumor SI lower than or equal to normal tissue SI on T2-weighted images and low ADC corresponded histopathologically to stromal hyper- cellularity. Other findings were not significant. Conclusion: Several MR findings can be used to help determine the histologic grade of phyllodes breast tumors.

Pulmonary lesions associated with visceral larva migrans due to Ascaris suum or Toxocara canis: Imaging of six cases

S Sakai, Y Shida, N Takahashi, H Yabuuchi, H Soeda, T Okafuji, M Hatakenaka, H Honda

AMERICAN JOURNAL OF ROENTGENOLOGY ( AMER ROENTGEN RAY SOC ) 186 ( 6 ) 1697 - 1702 2006.06 [Refereed]

OBJECTIVE. The objective of our study was to evaluate chest radiographic and CT findings of patients with pulmonary lesions associated with visceral larva migrans due to Ascaris suum or Toxocara canis. CT investigation was focused on the location, size, contour, and internal features of the lesions; migration of lesions; mediastinal lymphadenopathy; and pleural effusion. CONCLUSION. Pulmonary visceral larva migrans appears on CT as multifocal subpleural nodules with halo or ground-glass opacities and ill-defined margins.

A case of lymphangioleiomyomatosis affecting the supraclavicular lymph nodes

T Kamitani, H Yabuuchi, H Soeda, Y Matsuo, T Okafuji, S Sakai, M Hatakenaka, T Minami, H Inoue, A Tanaka, H Kohno, M Tanaka, Y Nakashima, H Honda

JOURNAL OF COMPUTER ASSISTED TOMOGRAPHY ( LIPPINCOTT WILLIAMS & WILKINS ) 30 ( 2 ) 279 - 282 2006.03 [Refereed]

The case of a 46-year-old woman with lymphangioleiomyomatosis (LAM) involving the supraclavicular, mediastinal, and pelvic lymph nodes in addition to the lungs is reported. Computed tomography incidentally revealed multiple thin-walled pulmonary cysts and low-attenuating masses in the supraclavicular, mediastinal, and retroperitoneal lymph nodes. A biopsy of the supraclavicular mass was performed and diagnosed as LAM histopathologically. The common sites of extrapulmonary LAM include retroperitoneal and mediastinal lymph nodes; however, supraclavicular lymph node involvement is extremely rare.

Steroid myopathy: Evaluation of fiber atrophy with T2 relaxation time - Rabbit and human study

M Hatakenaka, H Soeda, T Okafuji, H Yabuuchi, S Shiokawa, J Nishimura, H Honda

RADIOLOGY ( RADIOLOGICAL SOC NORTH AMERICA ) 238 ( 2 ) 650 - 657 2006.02 [Refereed]

Purpose: To determine whether muscle fiber atrophy associated with steroid myopathy can be detected with T2 relaxation time. Materials and Methods: Animal and human studies were approved by the ethics committee. Informed consent was obtained. Twelve rabbits were divided into a group that received 3 mg/kg of triamcinolone subcutaneously each day for 10 consecutive days (n = 6) and a control group that received saline (n = 6). Magnetic resonance (MR) imaging was performed before and after treatment. T2 and fat deposition ratio (FDR) of soleus and gastrocnemius muscles before and after treatment and between control rabbits and rabbits treated with steroids were compared by using two-way repeated analysis of variance and Bonferroni post hoc test to evaluate effects of steroid treatment. After imaging, rabbits were sacrificed. Extracellular space ratio (ECSR) and fiber diameter were examined. Correlation among T2, ECSR, and diameter of type 2 muscle fibers was analyzed with a Pearson correlation test with Bonferroni correction in gastrocnemius to determine factors affecting T2. In humans, T2 relaxation time and FDR of both muscles were compared between volunteers not treated with steroids and patients treated with steroids by using an unpaired t test to evaluate the effects of steroids. Results: In rabbits, T2 of gastrocnemius muscle was significantly (P < .01) longer after steroid treatment than before steroid treatment and was also significantly (P < .01) longer than after saline administration. T2 of the gastrocnemius showed no significant difference in control rabbits before or after saline administration or in control rabbits and rabbits before steroid administration. T2 of the soleus muscle or FDR of either muscle showed no significant difference. There was a significant correlation (P < .01) among T2, ECSR, and diameter of type 2 muscle fibers in the gastrocnemius. In humans, T2 of the gastrocnemius was significantly (P < .01) longer in patients than in volunteers. T2 of the soleus or FDR of either muscle showed no significant difference. Conclusion: Muscle fiber atrophy associated with steroid myopathy is detectable as prolongation of T2 relaxation time in the gastrocnemius muscle; the authors believe prolongation of T2 relaxation time is mainly due to increased ECSR reflecting type 2 muscle fiber atrophy. (c) RSNA, 2005.

Gorham's disease of the chest wall - CT and MR characteristics

T Okafuji, H Yabuuchi, H Soeda, N Takahashi, M Hatakenaka, S Sakai, Y Nishihara, N Noda, Inoshima, I, H Honda

JOURNAL OF THORACIC IMAGING ( LIPPINCOTT WILLIAMS & WILKINS ) 20 ( 4 ) 284 - 287 2005.11 [Refereed]

We report a case of Gorham's disease of the chest wall in a 29-year-old man. A chest radiograph showed osteolysis of the left first, second, and third ribs. CT and MR images revealed a soft tissue mass around the affected ribs. The mass presented as having heterogeneous high signal intensity on T2-weighted MR images, and it showed minimal enhancement on contrast-enhanced MR images. A histologic specimen obtained by incisional. biopsy from the left third rib revealed proliferation of lymphangiomatous tissue in the bone marrow. A diagnosis of Gorham's disease was made based on these clinical, radiologic, and histologic findings.

Clinically mild, atypical, and aged craniofacial syndrome is diagnosed as Crouzon syndrome by identification of a point mutation in the fibroblast growth factor receptor 2 gene (FGFR2)

T Maeda, M Hatakenaka, H Muta, M Nakayama, Y Nakazaki, T Hiroyama, T Suzuki, K Tani

INTERNAL MEDICINE ( JAPAN SOC INTERNAL MEDICINE ) 43 ( 5 ) 432 - 435 2004.05 [Refereed]

A 53-year-old Japanese woman presented with mild mental retardation, short stature, hypertelorism, saddle nose, vertebral fusion, and hydrocephalus, implying an underlying bone growth impairment mainly of the head and neck. A point mutation in fibroblast growth factor receptor 2 (FGFR2) was identified that had previously been seen only in sporadic cases of Crouzon syndrome. This patient did not exhibit any of the typical features of Crouzon syndrome primarily seen in affected infants, such as a severely deformed skull, an apical shaped skull, or severe mental retardation. The patient was diagnosed with a mild form of Crouzon syndrome. The patient's symptoms very early in life may have been ameliorated and modified through growth and aging. The age-related phenotype modifications in Crouzon syndrome are discussed.

Transient uterine myometrial contraction associated with moles

M Hatakenaka, K Yoshimitsu, T Adachi, T Matsuda, N Wake, H Honda

JOURNAL OF MAGNETIC RESONANCE IMAGING ( JOHN WILEY & SONS INC ) 19 ( 2 ) 182 - 187 2004.02 [Refereed]

Purpose: To examine the incidence of transient distortion of uterine central tissue and myometrial hypointense areas observed on MR images in women with clinically suspicious moles. Materials and Methods: The study population consisted of six women aged 15-47 years with clinically suspicious moles (hydatidiform mole in four, invasive mole in one, and microscopic mole in one). The control study population was 105 reproductive-age women (18-52 years) without uterine malignancy, gestational trophoblastic disease, or pregnancy. MR images were analyzed to check for discrepancies of the uterine central tissue configuration. If a discrepancy was observed, the myometrial hypointense area, its diameter, and changes in its shape and location were analyzed. Results: Differences in uterine central tissue configuration and hypointense areas were observed in all six patients. In the control study, only seven cases showed uterine endometrial distortion, and five exhibited hypointense areas. These areas disappeared, changed in shape, or other hypointense areas appeared on subsequent MR images. Significant differences (P<0.01) in the incidence of uterine central tissue distortion and hypointense areas, and in their maximum diameter between the study and the control groups were observed. Conclusion: Uterine myometrial hypointense areas with central tissue distortion, most likely due to transient myometrial contraction, are frequently seen in women with clinically suspicious moles.

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