MIYAJIMA Satsuki

写真a

Affiliation

School of Medicine, Department of Respiratory Medicine and Allergology

Job title

Assistant Professor
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Research Areas 【 display / non-display 】

  • Life sciences   Respiratory medicine  

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Papers 【 display / non-display 】

  • Bob1 maintains T follicular helper cells for long-term humoral immunity.

    Masahiro Yanagi, Ippei Ikegami, Ryuta Kamekura, Tatsuya Sato, Taiki Sato, Shiori Kamiya, Kosuke Murayama, Sumito Jitsukawa, Fumie Ito, Akira Yorozu, Miho Kihara, Takaya Abe, Hiromi Takaki, Koji Kawata, Katsunori Shigehara, Satsuki Miyajima, Hirotaka Nishikiori, Akinori Sato, Noritsugu Tohse, Ken-Ichi Takano, Hirofumi Chiba, Shingo Ichimiya

    Communications biology   7 ( 1 ) 185 - 185  2024.02  [International journal]

    　View Summary

    Humoral immunity is vital for host protection, yet aberrant antibody responses can trigger harmful inflammation and immune-related disorders. T follicular helper (Tfh) cells, central to humoral immunity, have garnered significant attention for unraveling immune mechanisms. This study shows the role of B-cell Oct-binding protein 1 (Bob1), a transcriptional coactivator, in Tfh cell regulation. Our investigation, utilizing conditional Bob1-deficient mice, suggests that Bob1 plays a critical role in modulating inducible T-cell costimulator expression and cellular respiration in Tfh cells. This regulation maintains the long-term functionality of Tfh cells, enabling their reactivation from central memory T cells to produce antibodies during recall responses. In a bronchial asthma model induced by house dust mite (HDM) inhalation, Bob1 is observed to enhance HDM-specific antibodies, including IgE, highlighting its pivotal function in Tfh cell regulation. Further exploration of Bob1-dependent mechanisms in Tfh cells holds promise for governing protective immunity and addressing immune-related disorders.

    DOI PubMed

  • Circulating T follicular helper 2 cells, T follicular regulatory cells and regulatory B cells are effective biomarkers for predicting the response to house dust mite sublingual immunotherapy in patients with allergic respiratory diseases

    Katsunori Shigehara, Ryuta Kamekura, Ippei Ikegami, Hiroshi Sakamoto, Masahiro Yanagi, Shiori Kamiya, Kentaro Kodama, Yuichiro Asai, Satsuki Miyajima, Hirotaka Nishikiori, Eiji Uno, Keisuke Yamamoto, Kenichi Takano, Hirofumi Chiba, Hirofumi Ohnishi, Shingo Ichimiya

    Frontiers in Immunology ( Frontiers Media SA )  14  2023.11

    　View Summary

    The relationships between T follicular helper (Tfh) cells and antigen-specific immunoglobulins (sIgs) in patients with allergic respiratory diseases who are receiving antigen immunotherapy (AIT) have not been fully clarified. Therefore, we started to perform house dust mite sublingual immunotherapy (HDM-SLIT) for 20 patients with atopic asthma comorbid with allergic rhinitis (AA+AR) who were already receiving ordinary treatments including inhaled corticosteroid (ICS). We examined percentages of circulating T follicular helper (cTfh) and regulatory (cTfr) cells and percentages of circulating regulatory T (cTreg) and B (cBreg) cells by FACS and we examined levels of Der-p/f sIgs by ELISA. Based on the symptom score (asthma control questionnaire: ACQ) and medication score ((global initiative for asthma: GINA) treatment step score) in patients with AA, the patients were divided into responders and non-responders. The percentage of cTfh2 cells significantly decreased and the percentage of cTfh1 cells significantly increased within the first year. Der-p/f sIgEs decreased after a transient elevation at 3 months in both groups. Notably, the percentage of cTfh2 cells and the ratio of cTfh2/cBreg cells and Der-p/f sIgEs greatly decreased in responders from 6 months to 12 months. The percentages of cTfr and cTreg cells showed significant negative correlations with the percentage of cTfh2 cells. The percentage of IL-4+ cTfh cells were significantly decreased and the percentage of IFN-γ+ cTfh cells were increased before treatment to 24 months in 6 patients examined (4 responders and 2 non-responders). We performed multi plelogistic regression analysis based on these results, the ratios of cTfh2/cTfr cells and cTfh2/cBreg cells at the start of therapy were statistically effective biomarkers for predicting the response to HDM-SLIT in patients with AA+AR.

    DOI

  • 免疫療法・薬物療法(臨床) 鼻炎合併喘息患者におけるダニ舌下免疫療法のICS減量効果 3年間の解析

    重原 克則, 亀倉 隆太, 宮島 さつき, 小玉 賢太郎, 錦織 博貴, 千葉 弘文

    アレルギー ( (一社)日本アレルギー学会 )  72 ( 6-7 ) 882 - 882  2023.08

  • 喘息 治療 アレルギー性鼻炎合併喘息の家塵ダニ舌下免疫療法における吸入ステロイド減量効果

    重原 克則, 亀倉 隆太, 宮島 さつき, 小玉 賢太郎, 柳 昌弘, 錦織 博貴, 千葉 弘文

    日本呼吸器学会誌 ( (一社)日本呼吸器学会 )  12 ( 増刊 ) 185 - 185  2023.03

  • 細径胆管造影針を用いて施行したエコーガイド下経皮生検の検討

    竹中 遥, 高橋 守, 伊東 菜亜美, 森川 皓平, 池田 拓海, 安田 健人, 小玉 賢太郎, 齋藤 充史, 宮島 さつき, 千葉 弘文

    日本呼吸器学会誌 ( (一社)日本呼吸器学会 )  11 ( 増刊 ) 216 - 216  2022.04

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Misc 【 display / non-display 】

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Research Projects 【 display / non-display 】

  • COPDの慢性炎症における濾胞ヘルパーT細胞・末梢性ヘルパーT細胞の解析

    若手研究

    Project Year :

    2022.04
    -
    2025.03
     

    宮島 さつき

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