2025/08/22 更新

写真a

ミヤジマ　サツキ
宮島　さつき
所属
医学部 内科学講座呼吸器・アレルギー内科学分野 助教
職名
助教
外部リンク

研究分野

  • ライフサイエンス / 呼吸器内科学

論文

  • Bob1 maintains T follicular helper cells for long-term humoral immunity. 国際誌

    Masahiro Yanagi, Ippei Ikegami, Ryuta Kamekura, Tatsuya Sato, Taiki Sato, Shiori Kamiya, Kosuke Murayama, Sumito Jitsukawa, Fumie Ito, Akira Yorozu, Miho Kihara, Takaya Abe, Hiromi Takaki, Koji Kawata, Katsunori Shigehara, Satsuki Miyajima, Hirotaka Nishikiori, Akinori Sato, Noritsugu Tohse, Ken-Ichi Takano, Hirofumi Chiba, Shingo Ichimiya

    Communications biology   7 ( 1 )   185 - 185   2024年2月

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    記述言語：英語   掲載種別：研究論文（学術雑誌）  

    Humoral immunity is vital for host protection, yet aberrant antibody responses can trigger harmful inflammation and immune-related disorders. T follicular helper (Tfh) cells, central to humoral immunity, have garnered significant attention for unraveling immune mechanisms. This study shows the role of B-cell Oct-binding protein 1 (Bob1), a transcriptional coactivator, in Tfh cell regulation. Our investigation, utilizing conditional Bob1-deficient mice, suggests that Bob1 plays a critical role in modulating inducible T-cell costimulator expression and cellular respiration in Tfh cells. This regulation maintains the long-term functionality of Tfh cells, enabling their reactivation from central memory T cells to produce antibodies during recall responses. In a bronchial asthma model induced by house dust mite (HDM) inhalation, Bob1 is observed to enhance HDM-specific antibodies, including IgE, highlighting its pivotal function in Tfh cell regulation. Further exploration of Bob1-dependent mechanisms in Tfh cells holds promise for governing protective immunity and addressing immune-related disorders.

    DOI： 10.1038/s42003-024-05827-0

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  • Circulating T follicular helper 2 cells, T follicular regulatory cells and regulatory B cells are effective biomarkers for predicting the response to house dust mite sublingual immunotherapy in patients with allergic respiratory diseases

    Katsunori Shigehara, Ryuta Kamekura, Ippei Ikegami, Hiroshi Sakamoto, Masahiro Yanagi, Shiori Kamiya, Kentaro Kodama, Yuichiro Asai, Satsuki Miyajima, Hirotaka Nishikiori, Eiji Uno, Keisuke Yamamoto, Kenichi Takano, Hirofumi Chiba, Hirofumi Ohnishi, Shingo Ichimiya

    Frontiers in Immunology   14   2023年11月

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    掲載種別：研究論文（学術雑誌）   出版者・発行元：Frontiers Media SA  

    The relationships between T follicular helper (Tfh) cells and antigen-specific immunoglobulins (sIgs) in patients with allergic respiratory diseases who are receiving antigen immunotherapy (AIT) have not been fully clarified. Therefore, we started to perform house dust mite sublingual immunotherapy (HDM-SLIT) for 20 patients with atopic asthma comorbid with allergic rhinitis (AA+AR) who were already receiving ordinary treatments including inhaled corticosteroid (ICS). We examined percentages of circulating T follicular helper (cTfh) and regulatory (cTfr) cells and percentages of circulating regulatory T (cTreg) and B (cBreg) cells by FACS and we examined levels of Der-p/f sIgs by ELISA. Based on the symptom score (asthma control questionnaire: ACQ) and medication score ((global initiative for asthma: GINA) treatment step score) in patients with AA, the patients were divided into responders and non-responders. The percentage of cTfh2 cells significantly decreased and the percentage of cTfh1 cells significantly increased within the first year. Der-p/f sIgEs decreased after a transient elevation at 3 months in both groups. Notably, the percentage of cTfh2 cells and the ratio of cTfh2/cBreg cells and Der-p/f sIgEs greatly decreased in responders from 6 months to 12 months. The percentages of cTfr and cTreg cells showed significant negative correlations with the percentage of cTfh2 cells. The percentage of IL-4<sup>+</sup> cTfh cells were significantly decreased and the percentage of IFN-γ<sup>+</sup> cTfh cells were increased before treatment to 24 months in 6 patients examined (4 responders and 2 non-responders). We performed multi plelogistic regression analysis based on these results, the ratios of cTfh2/cTfr cells and cTfh2/cBreg cells at the start of therapy were statistically effective biomarkers for predicting the response to HDM-SLIT in patients with AA+AR.

    DOI： 10.3389/fimmu.2023.1284205

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  • 免疫療法・薬物療法(臨床) 鼻炎合併喘息患者におけるダニ舌下免疫療法のICS減量効果 3年間の解析

    重原 克則, 亀倉 隆太, 宮島 さつき, 小玉 賢太郎, 錦織 博貴, 千葉 弘文

    アレルギー   72 ( 6-7 )   882 - 882   2023年8月

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    記述言語：日本語   出版者・発行元：(一社)日本アレルギー学会  

    医中誌

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  • 喘息 治療 アレルギー性鼻炎合併喘息の家塵ダニ舌下免疫療法における吸入ステロイド減量効果

    重原 克則, 亀倉 隆太, 宮島 さつき, 小玉 賢太郎, 柳 昌弘, 錦織 博貴, 千葉 弘文

    日本呼吸器学会誌   12 ( 増刊 )   185 - 185   2023年3月

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    記述言語：日本語   出版者・発行元：(一社)日本呼吸器学会  

    医中誌

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  • 細径胆管造影針を用いて施行したエコーガイド下経皮生検の検討

    竹中 遥, 高橋 守, 伊東 菜亜美, 森川 皓平, 池田 拓海, 安田 健人, 小玉 賢太郎, 齋藤 充史, 宮島 さつき, 千葉 弘文

    日本呼吸器学会誌   11 ( 増刊 )   216 - 216   2022年4月

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    記述言語：日本語   出版者・発行元：(一社)日本呼吸器学会  

    医中誌

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  • 局所麻酔下胸腔鏡検査におけるクライオバイオプシーの有用性についての検討

    槌本 朱里, 齋藤 充史, 伊東 菜亜美, 森川 皓平, 安田 健人, 池田 拓海, 竹中 遥, 小玉 賢太郎, 宮島 さつき, 高橋 守, 千葉 弘文

    気管支学   43 ( 6 )   689 - 690   2021年11月

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    記述言語：日本語   出版者・発行元：(一社)日本呼吸器内視鏡学会  

    医中誌

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  • 局所麻酔下胸腔鏡検査におけるクライオバイオプシーの有用性についての検討

    槌本 朱里, 齋藤 充史, 伊東 菜亜美, 森川 皓平, 安田 健人, 池田 拓海, 竹中 遥, 小玉 賢太郎, 宮島 さつき, 高橋 守, 千葉 弘文

    気管支学   43 ( 6 )   689 - 690   2021年11月

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    記述言語：日本語   出版者・発行元：(NPO)日本呼吸器内視鏡学会  

    医中誌

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  • Dilemma of physician-mothers faced with an increased home burden and clinical duties in the hospital during the COVID-19 pandemic. 国際誌

    Sachiyo Nishida, Kanna Nagaishi, Masayo Motoya, Ayako Kumagai, Noriko Terada, Ai Kasuga, Narumi Kubota, Kotoe Iesato, Motonobu Kimizuka, Satsuki Miyajima, Masayuki Koyama, Hirofumi Ohnishi, Eichi Narimatsu, Naoya Masumori, Kazufumi Tsuchihashi, Taiji Tsukamoto, Yoshihisa Tsuji

    PloS one   16 ( 6 )   e0253646   2021年

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    記述言語：英語   掲載種別：研究論文（学術雑誌）  

    PURPOSE: Since December 2019, coronavirus disease 2019 (COVID-19) has spread rapidly across the world. During the pandemic, physicians in our hospital have had to respond both to the issue of treating the patients and the increasing domestic burden associated with social disruption. The purpose of this study was to assess how much the burden on our doctors, especially female doctors, was increasing. MATERIAL AND METHODS: The Physicians' Career Support Committee in Sapporo Medical University conducted a questionnaire survey. The questionnaire inquired about a wide range of subjects with regard to working style and family life during the first and second waves of the COVID-19 pandemic, and was sent to all medical/dental physicians working in Sapporo Medical University. RESULTS: A total of 266 (42.7%) physicians in our hospital responded to our questionnaire and the data for 264 data were analyzed. The total numbers of males, females, and others, including those who did not want to specify, were 178 (67.4%), 82 (31.0%), and 4 (1.5%), respectively. Among them, 62 (23.5%) and 23 (8.7%) answered that their domestic burden was slightly or markedly increased. The increase in the domestic burden showed a significant difference between genders (p = 0.04). Even after correction for background differences using multivariate analysis, being female (p<0.001), having child dependents (p<0.001), and treating COVID-19 patients (p = 0.03) were significantly related to an increased domestic burden. Regarding family style, 58.1% of the physician-fathers were from two-income families (i.e., families with both parents in employment), and they answered that their partner mainly cared for the children. In contrast, 97.3% of physician-mothers were from two-income families, and 94.6% of the physician-mothers had to take care of children by themselves. CONCLUSION: Physician-mothers are caught in a dilemma between an increased home burden and clinical duties in the hospital, with a significantly higher ratio than physician-fathers during the pandemic. As we showed, female doctors could have not continued their careers and take responsible positions in the same way as male doctors. This is a social risk in the timing of a crisis, such as a pandemic.

    DOI： 10.1371/journal.pone.0253646

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  • 治療開始7ヵ月後にParadoxical reactionを来した粟粒結核の1例

    今井 優衣, 宮島 さつき, 鎌田 弘毅, 佐々原 正幸, 宮坂 友紀, 林 智弘, 小玉 賢太郎, 吉川 匠, 斎藤 充史, 高橋 守, 千葉 弘文, 高橋 弘毅

    日本サルコイドーシス/肉芽腫性疾患学会雑誌   40 ( 1-2 )   57 - 57   2020年10月

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    記述言語：日本語   出版者・発行元：日本サルコイドーシス  

    医中誌

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  • 北海道支部3大学共同ワーキンググループの取り組み

    長井 桂, 清水 薫子, 宮島 さつき, 橋本 みどり, 佐々木 高明, 高村 圭, 岡本 佳裕, 千葉 弘文, 長内 忍, 日本呼吸器学会北海道支部将来計画委員会/男女共同参画委員会

    日本呼吸器学会誌   9 ( 増刊 )   78 - 78   2020年8月

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    記述言語：日本語   出版者・発行元：(一社)日本呼吸器学会  

    医中誌

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  • Activated circulating T follicular helper cells and skewing of T follicular helper 2 cells are down-regulated by treatment including an inhaled corticosteroid in patients with allergic asthma. 国際誌

    Satsuki Miyajima, Katsunori Shigehara, Ryuta Kamekura, Hiromi Takaki, Hayato Yabe, Ippei Ikegami, Yuichiro Asai, Hirotaka Nishikiori, Hirohumi Chiba, Eiji Uno, Hiroki Takahashi, Shingo Ichimiya

    Allergology international : official journal of the Japanese Society of Allergology   69 ( 1 )   66 - 77   2020年1月

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    記述言語：英語   掲載種別：研究論文（学術雑誌）  

    BACKGROUND: CXCR5+ T follicular helper (TFH) cells primarily promote B cells to produce an antigen-specific antibody through germinal centers (GCs). TFH cells exist in circulation, and circulating(c) TFH2 cells, a subset of cTFH cells, are able to help naïve B cells produce IgE in healthy individuals. Conversely, IL-10-producing regulatory B (Breg) cells inhibit an accelerated immune response. METHODS: We investigated the roles of cTFH cells and cBreg cells based on a TH2 response in patients with atopic asthma (AA). Thirty-two patients with AA and 35 healthy volunteers (HV) were enrolled. We examined cTFH cells including their subsets, their expression of ICOS and PD-1, and cBreg cells by flow cytometry and their associations with clinical biomarkers. Plasma levels of CXCL13, which is a counterpart of CXCR5, were also measured using ELISA. RESULTS: In patients with AA, cTFH2 cells were increased and cTFH1 cells were decreased compared with those in HV. The expression levels of ICOS on cTFH and their subset cells were elevated and Breg cells were greatly decreased. The plasma levels of CXCL13 in patients with AA were significantly elevated and correlated well with the cTFH2/cBreg ratio. These cells were examined in 10 patients AA before and after inhaled corticosteroid (ICS) treatment. Interestingly, the percentages and numbers of TFH2 and ICOS+ cTFH cells declined after ICS treatment together with improvements in symptoms and clinical biomarkers. CONCLUSIONS: The percentages and numbers of cTFH2 and ICOS+ cTFH cells might be useful as biomarkers of TH2 typed airway inflammation in patients with AA.

    DOI： 10.1016/j.alit.2019.08.008

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  • Aberrant populations of circulating T follicular helper cells and regulatory B cells underlying idiopathic pulmonary fibrosis. 国際誌

    Yuichiro Asai, Hirofumi Chiba, Hirotaka Nishikiori, Ryuta Kamekura, Hayato Yabe, Shun Kondo, Satsuki Miyajima, Katsunori Shigehara, Shingo Ichimiya, Hiroki Takahashi

    Respiratory research   20 ( 1 )   244 - 244   2019年11月

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    記述言語：英語   掲載種別：研究論文（学術雑誌）  

    BACKGROUND: T follicular helper (Tfh) cells have been identified as a new category of helper T cells, which express CXCR5 on their surface and induce the production of antigen-specific antibodies. Many investigations have found morbid proliferation and/or activation of Tfh cells in systemic autoimmune and allergic diseases. It is also known that Tfh cells are regulated by regulatory B (Breg) cells in the deteriorating such diseases. Recently, CXCL13, a ligand of CXCR5, has been reported to increase in the peripheral blood and lungs of patients with idiopathic pulmonary fibrosis (IPF). This study aimed to investigate the involvement of Tfh cells and Breg cells in IPF. METHODS: Peripheral blood samples were obtained from 18 patients with IPF. We isolated heparinized peripheral blood mononuclear cells and investigated the proportions of Breg cells, Tfh cells, PD-1+ICOS+ Tfh cells (activated form of Tfh cells), and the Tfh-cell subsets by flow cytometry. These cell profiles were compared with those of 21 healthy controls. Furthermore, we investigated the correlations between profiles of lymphocytes and lung physiology. RESULTS: The median proportions of Tfh cells per total CD4+ T cells and of PD-1+ICOS+ proportion of Tfh cells per total Tfh cells was significantly more in the IPF patients (20.4 and 5.2%, respectively) compared with healthy controls (15.4 and 2.1%, respectively; p = 0.042 and p = 0.004, respectively). The proportion of Tfh2 cells per total Tfh cells was significantly higher and the proportion of Tfh17 was smaller in the IPF patients than healthy controls. The percentage of Breg cells to total B cells was significantly decreased in the IPF patients (median, 8.5%) compared with that in the controls (median, 19.7%; p < 0.001). The proportion of Breg cells was positively correlated with the annual relative change in diffusing capacity of the lungs for carbon monoxide in the IPF patients (r = 0.583, p = 0.018). CONCLUSION: Proliferation and activation of Tfh cells and a decrease in Breg cells were observed in the peripheral blood of patients with IPF. The profile of the Tfh-cell subset also changed. Specific humoral immunity aberration would likely underlie complicated pathophysiology of IPF.

    DOI： 10.1186/s12931-019-1216-6

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  • A case of tracheal pleomorphic adenoma misdiagnosed as asthma. 国際誌

    Mamoru Takahashi, Takahumi Yorozuya, Yuki Miyasaka, Kentaro Kodama, Takumi Yoshikawa, Tetsuya Taya, Yuki Mori, Kimiyuki Ikeda, Satsuki Miyajima, Hirofumi Chiba, Hiroki Takahashi

    Oxford medical case reports   2019 ( 11 )   omz111   2019年11月

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    記述言語：英語  

    A 51-year-old woman had an incidental finding of a tracheal tumor during oesophagogastroduodenoscopy following the diagnosis of asthma for 2 months. A computed tomography scan revealed a 15-mm tumor in the subglottis. Endoscopic resection was performed safely, and pleomorphic adenoma was diagnosed histologically. The patient's condition was satisfactory 30 months after the procedure. Tracheal pleomorphic adenoma is rare and may be misdiagnosed as asthma. If the tumor is large, surgery may be required; however, endoscopic polypectomy may be effective if the tumor is small. Therefore, early diagnosis of tracheal pleomorphic adenoma is important. At the first visit, the flow-volume curve suggested upper airway obstruction, which should have raised the suspicion of an upper airway obstruction. In patients with suspected asthma, early pulmonary function testing is needed to substantiate asthma diagnosis and prevent an alternative diagnosis being missed.

    DOI： 10.1093/omcr/omz111

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  • Autoimmune Pulmonary Alveolar Proteinosis Diagnosed after Exposure to a Fire Extinguisher Containing Silica Powder.

    Takafumi Yorozuya, Kimiyuki Ikeda, Hirofumi Chiba, Atsushi Saito, Koji Kuronuma, Hirotaka Nishikiori, Satsuki Miyajima, Mamoru Takahashi, Takumi Yoshikawa, Youhei Takahashi, Tetsuya Taya, Yuki Mori, Yasuaki Umeda, Mitsuo Otsuka, Hiroshi Moriyama, Hiroki Takahashi

    Internal medicine (Tokyo, Japan)   58 ( 14 )   2067 - 2072   2019年7月

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    記述言語：英語   掲載種別：研究論文（学術雑誌）  

    We herein report a case of autoimmune pulmonary alveolar proteinosis (PAP) diagnosed after one-time exposure to silica powder. Owing to the misuse of a silica-containing fire extinguisher and the inhalation of large amounts of its powder, the patient experienced prolonged cough and visited our hospital. The findings of chest computed tomography and surgical lung biopsy specimens led to the diagnosis of PAP. Interestingly, the presence of anti-GM-CSF antibody was detected; therefore, both autoimmune characteristics and exposure to large amounts of silica may have caused the development of PAP in this patient. This case provides important insight into the mechanisms leading to the onset of PAP.

    DOI： 10.2169/internalmedicine.1557-18

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  • Alteration of circulating type 2 follicular helper T cells and regulatory B cells underlies the comorbid association of allergic rhinitis with bronchial asthma. 国際誌

    Ryuta Kamekura, Katsunori Shigehara, Satsuki Miyajima, Sumito Jitsukawa, Koji Kawata, Keiji Yamashita, Tomonori Nagaya, Ayako Kumagai, Akinori Sato, Hiroshi Matsumiya, Noriko Ogasawara, Nobuhiko Seki, Kenichi Takano, Yasuo Kokai, Hiroki Takahashi, Tetsuo Himi, Shingo Ichimiya

    Clinical immunology (Orlando, Fla.)   158 ( 2 )   204 - 11   2015年6月

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    記述言語：英語   掲載種別：研究論文（学術雑誌）  

    Allergic rhinitis (AR), the most common allergic disorder of the airway, is often accompanied by bronchial asthma. However, little is known about the mechanism by which AR advances to AR comorbid with bronchial asthma (AR+Asthma). To determine the pathophysiologic features of AR and AR+Asthma, we examined subsets of follicular helper T (Tfh) cells and regulatory B (Breg) cells in peripheral blood from AR and AR+Asthma patients. The results showed polarization of Tfh2 cells within Tfh cell subsets in both AR and AR+Asthma cases. Interestingly, the %Breg cells in total B cells were decreased in AR cases and, more extensively, in AR+Asthma cases. Moreover, we found significant correlations of fractional exhaled nitric oxide and blood eosinophil levels with the index %Tfh2 cells per %Breg cells. Our findings indicate that relative decrease in Breg cells under the condition of Tfh2 cell skewing is a putative exaggerating factor of AR to bronchial asthma.

    DOI： 10.1016/j.clim.2015.02.016

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  • A case of adult T cell leukemia/lymphoma presenting as severe tracheal stenosis.

    Kengo Otsuka, Koji Kuronuma, Mitsuo Otsuka, Junya Kitada, Yoshifumi Narita, Hirotoshi Homma, Satsuki Miyajima, Yasuo Kitamura, Yosuke Suzuki, Motoki Natsuizaka, Hiroshi Yasui, Hiroshi Ikeda, Toshiaki Hayashi, Tadao Ishida, Yasuhisa Shinomura, Hiroko Noguchi, Hiroki Takahashi

    Internal medicine (Tokyo, Japan)   50 ( 21 )   2637 - 41   2011年

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    記述言語：英語   掲載種別：研究論文（学術雑誌）  

    A 57-year-old woman was referred to our hospital for further examination of a tracheal stenosis shown on computed tomography findings. Bronchoscopy revealed multiple protruding tumors in the lumen of the trachea. Cytological findings of the cell block material from pleural effusion indicated that the T-cell lymphoma was composed of pleomorphic lymphoid cells. Serum human T-cell leukemia virus type 1 antibody was positive and supported the clinical diagnosis of ATLL. Systemic chemotherapy induced the remarkable improvement of the lesions, the infiltrative lung shadow and the soft tissue neoplasm. We report a rare case of adult T cell leukemia/lymphoma (ATLL) with endobronchial involvement.

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  • 3.気管狭窄に対して,人工心肺下で気管内ステント留置術を施行した舌癌の1例(第28回 日本呼吸器内視鏡学会北海道支部会)

    本間 裕敏, 宮島 さつき, 北田 順也, 田中 康正, 大塚 満雄, 工藤 和実, 白鳥 正典, 高橋 弘毅

    気管支学   29 ( 1 )   58 - 58   2007年

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    記述言語：日本語   出版者・発行元：特定非営利活動法人 日本呼吸器内視鏡学会  

    DOI： 10.18907/jjsre.29.1_58_3

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共同研究・競争的資金等の研究課題

  • COPDの慢性炎症における濾胞ヘルパーT細胞・末梢性ヘルパーT細胞の解析

    研究課題/領域番号：22K16176  2022年4月 - 2025年3月

    日本学術振興会  科学研究費助成事業  若手研究

    宮島 さつき

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    配分額：4550000円 （ 直接経費：3500000円 、 間接経費：1050000円 ）

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