宮島 さつき (ミヤジマ サツキ)

写真a

所属

医学部 呼吸器・アレルギー内科学講座

職名

助教

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  • ライフサイエンス   呼吸器内科学  

 

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  • Bob1 maintains T follicular helper cells for long-term humoral immunity.

    Masahiro Yanagi, Ippei Ikegami, Ryuta Kamekura, Tatsuya Sato, Taiki Sato, Shiori Kamiya, Kosuke Murayama, Sumito Jitsukawa, Fumie Ito, Akira Yorozu, Miho Kihara, Takaya Abe, Hiromi Takaki, Koji Kawata, Katsunori Shigehara, Satsuki Miyajima, Hirotaka Nishikiori, Akinori Sato, Noritsugu Tohse, Ken-Ichi Takano, Hirofumi Chiba, Shingo Ichimiya

    Communications biology   7 ( 1 ) 185 - 185  2024年02月  [国際誌]

     概要を見る

    Humoral immunity is vital for host protection, yet aberrant antibody responses can trigger harmful inflammation and immune-related disorders. T follicular helper (Tfh) cells, central to humoral immunity, have garnered significant attention for unraveling immune mechanisms. This study shows the role of B-cell Oct-binding protein 1 (Bob1), a transcriptional coactivator, in Tfh cell regulation. Our investigation, utilizing conditional Bob1-deficient mice, suggests that Bob1 plays a critical role in modulating inducible T-cell costimulator expression and cellular respiration in Tfh cells. This regulation maintains the long-term functionality of Tfh cells, enabling their reactivation from central memory T cells to produce antibodies during recall responses. In a bronchial asthma model induced by house dust mite (HDM) inhalation, Bob1 is observed to enhance HDM-specific antibodies, including IgE, highlighting its pivotal function in Tfh cell regulation. Further exploration of Bob1-dependent mechanisms in Tfh cells holds promise for governing protective immunity and addressing immune-related disorders.

    DOI PubMed

  • Circulating T follicular helper 2 cells, T follicular regulatory cells and regulatory B cells are effective biomarkers for predicting the response to house dust mite sublingual immunotherapy in patients with allergic respiratory diseases

    Katsunori Shigehara, Ryuta Kamekura, Ippei Ikegami, Hiroshi Sakamoto, Masahiro Yanagi, Shiori Kamiya, Kentaro Kodama, Yuichiro Asai, Satsuki Miyajima, Hirotaka Nishikiori, Eiji Uno, Keisuke Yamamoto, Kenichi Takano, Hirofumi Chiba, Hirofumi Ohnishi, Shingo Ichimiya

    Frontiers in Immunology ( Frontiers Media SA )  14  2023年11月

     概要を見る

    The relationships between T follicular helper (Tfh) cells and antigen-specific immunoglobulins (sIgs) in patients with allergic respiratory diseases who are receiving antigen immunotherapy (AIT) have not been fully clarified. Therefore, we started to perform house dust mite sublingual immunotherapy (HDM-SLIT) for 20 patients with atopic asthma comorbid with allergic rhinitis (AA+AR) who were already receiving ordinary treatments including inhaled corticosteroid (ICS). We examined percentages of circulating T follicular helper (cTfh) and regulatory (cTfr) cells and percentages of circulating regulatory T (cTreg) and B (cBreg) cells by FACS and we examined levels of Der-p/f sIgs by ELISA. Based on the symptom score (asthma control questionnaire: ACQ) and medication score ((global initiative for asthma: GINA) treatment step score) in patients with AA, the patients were divided into responders and non-responders. The percentage of cTfh2 cells significantly decreased and the percentage of cTfh1 cells significantly increased within the first year. Der-p/f sIgEs decreased after a transient elevation at 3 months in both groups. Notably, the percentage of cTfh2 cells and the ratio of cTfh2/cBreg cells and Der-p/f sIgEs greatly decreased in responders from 6 months to 12 months. The percentages of cTfr and cTreg cells showed significant negative correlations with the percentage of cTfh2 cells. The percentage of IL-4+ cTfh cells were significantly decreased and the percentage of IFN-γ+ cTfh cells were increased before treatment to 24 months in 6 patients examined (4 responders and 2 non-responders). We performed multi plelogistic regression analysis based on these results, the ratios of cTfh2/cTfr cells and cTfh2/cBreg cells at the start of therapy were statistically effective biomarkers for predicting the response to HDM-SLIT in patients with AA+AR.

    DOI

  • 細径胆管造影針を用いて施行したエコーガイド下経皮生検の検討

    竹中 遥, 高橋 守, 伊東 菜亜美, 森川 皓平, 池田 拓海, 安田 健人, 小玉 賢太郎, 齋藤 充史, 宮島 さつき, 千葉 弘文

    日本呼吸器学会誌 ( (一社)日本呼吸器学会 )  11 ( 増刊 ) 216 - 216  2022年04月

  • 局所麻酔下胸腔鏡検査におけるクライオバイオプシーの有用性についての検討

    槌本 朱里, 齋藤 充史, 伊東 菜亜美, 森川 皓平, 安田 健人, 池田 拓海, 竹中 遥, 小玉 賢太郎, 宮島 さつき, 高橋 守, 千葉 弘文

    気管支学 ( (NPO)日本呼吸器内視鏡学会 )  43 ( 6 ) 689 - 690  2021年11月

  • Dilemma of physician-mothers faced with an increased home burden and clinical duties in the hospital during the COVID-19 pandemic.

    Sachiyo Nishida, Kanna Nagaishi, Masayo Motoya, Ayako Kumagai, Noriko Terada, Ai Kasuga, Narumi Kubota, Kotoe Iesato, Motonobu Kimizuka, Satsuki Miyajima, Masayuki Koyama, Hirofumi Ohnishi, Eichi Narimatsu, Naoya Masumori, Kazufumi Tsuchihashi, Taiji Tsukamoto, Yoshihisa Tsuji

    PloS one   16 ( 6 ) e0253646  2021年  [国際誌]

     概要を見る

    PURPOSE: Since December 2019, coronavirus disease 2019 (COVID-19) has spread rapidly across the world. During the pandemic, physicians in our hospital have had to respond both to the issue of treating the patients and the increasing domestic burden associated with social disruption. The purpose of this study was to assess how much the burden on our doctors, especially female doctors, was increasing. MATERIAL AND METHODS: The Physicians' Career Support Committee in Sapporo Medical University conducted a questionnaire survey. The questionnaire inquired about a wide range of subjects with regard to working style and family life during the first and second waves of the COVID-19 pandemic, and was sent to all medical/dental physicians working in Sapporo Medical University. RESULTS: A total of 266 (42.7%) physicians in our hospital responded to our questionnaire and the data for 264 data were analyzed. The total numbers of males, females, and others, including those who did not want to specify, were 178 (67.4%), 82 (31.0%), and 4 (1.5%), respectively. Among them, 62 (23.5%) and 23 (8.7%) answered that their domestic burden was slightly or markedly increased. The increase in the domestic burden showed a significant difference between genders (p = 0.04). Even after correction for background differences using multivariate analysis, being female (p<0.001), having child dependents (p<0.001), and treating COVID-19 patients (p = 0.03) were significantly related to an increased domestic burden. Regarding family style, 58.1% of the physician-fathers were from two-income families (i.e., families with both parents in employment), and they answered that their partner mainly cared for the children. In contrast, 97.3% of physician-mothers were from two-income families, and 94.6% of the physician-mothers had to take care of children by themselves. CONCLUSION: Physician-mothers are caught in a dilemma between an increased home burden and clinical duties in the hospital, with a significantly higher ratio than physician-fathers during the pandemic. As we showed, female doctors could have not continued their careers and take responsible positions in the same way as male doctors. This is a social risk in the timing of a crisis, such as a pandemic.

    DOI PubMed

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Misc 【 表示 / 非表示

  • 高周波凝固法が有効であった多発気管・気管支乳頭腫の1例

    宮坂 友紀, 宮島 さつき, 関川 元基, 佐々原 正幸, 小玉 賢太郎, 斎藤 充史, 高橋 守, 黒沼 幸治, 千葉 弘文

    気管支学 ( (NPO)日本呼吸器内視鏡学会 )  42 ( 6 ) 575 - 575  2020年11月

  • 治療開始7ヵ月後にParadoxical reactionを来した粟粒結核の1例

    今井 優衣, 宮島 さつき, 鎌田 弘毅, 佐々原 正幸, 宮坂 友紀, 林 智弘, 小玉 賢太郎, 吉川 匠, 斎藤 充史, 高橋 守, 千葉 弘文, 高橋 弘毅

    日本サルコイドーシス/肉芽腫性疾患学会雑誌 ( 日本サルコイドーシス )  40 ( 1-2 ) 57 - 57  2020年10月

  • オシメルチニブからエルロチニブに変更することでEGFR-TKIを継続し得た慢性心不全合併肺腺癌の一例

    関川 元基, 宮坂 友紀, 林 智宏, 小玉 賢太郎, 齋藤 充史, 宮島 さつき, 高橋 守, 千葉 弘文

    肺癌 ( (NPO)日本肺癌学会 )  60 ( 6 ) 764 - 764  2020年10月

  • 北海道支部3大学共同ワーキンググループの取り組み

    長井 桂, 清水 薫子, 宮島 さつき, 橋本 みどり, 佐々木 高明, 高村 圭, 岡本 佳裕, 千葉 弘文, 長内 忍, 日本呼吸器学会北海道支部将来計画委員会/男女共同参画委員会

    日本呼吸器学会誌 ( (一社)日本呼吸器学会 )  9 ( 増刊 ) 78 - 78  2020年08月

  • 同種造血幹細胞移植後にEBウイルス関連リンパ増殖症を発症したATLの1例

    清原 千貴, 宮島 真理, 高野 幹, 下山 格, 西谷 真来, 菅原 教史, 佐々木 了政, 岡野 良昭, 泉田 亘, 上原 さつき, 筑紫 泰彦, 古和田 周吾, 小宅 達郎, 伊藤 薫樹

    臨床血液 ( (一社)日本血液学会-東京事務局 )  61 ( 4 ) 417 - 417  2020年04月

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共同研究・競争的資金等の研究課題 【 表示 / 非表示

  • COPDの慢性炎症における濾胞ヘルパーT細胞・末梢性ヘルパーT細胞の解析

    若手研究

    研究期間:

    2022年04月
    -
    2025年03月
     

    宮島 さつき