Education 【 display / non-display 】

Education 【 display / non-display 】

• 2010

  -

  2013

  Nagoya University   医学系研究科 短縮修了（医学博士）  

• 2008

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  2010

  Hiroshima University   保健学研究科 修了（保健学修士）  

Degree 【 display / non-display 】

Degree 【 display / non-display 】

• 名古屋大学   博士（医学）

Research Experience 【 display / non-display 】

Research Experience 【 display / non-display 】

• 2024.04

  -

  Now

  札幌医科大学 保健医療学部 理学療法学科   准教授

• 2020.04

  -

  2024.03

  Sapporo Medical University   School of Health Sciences   講師

• 2019.10

  -

  2019.12

  University of Iowa, Human Integrative and Cardiovascular Physiology Laboratory  

• 2016.09

  -

  2017.09

  University of Iowa   Human Integrative and Cardiovascular Physiology Laboratory  

• 2013.04

  -

  2020.03

  Sapporo Medical University   助教

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Professional Memberships 【 display / non-display 】

Professional Memberships 【 display / non-display 】

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  JAPANESE PHYSICAL THERAPY ASSOCIATION

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  THE JAPANESE SOCIETY OF PHYSICAL FITNESS AND SPORTS MEDICINE

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  日本基礎理学療法学会

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  American Physiological Society

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  American College of Sports Medicine

Research Areas 【 display / non-display 】

Research Areas 【 display / non-display 】

• Life sciences   Sports science  

• Life sciences   Rehabilitation science  

Affiliation 【 display / non-display 】

Affiliation 【 display / non-display 】

• University of Iowa / Human Integrative and Cardiovascular Physiology Laboratory   Visiting scholar  

• Sapporo Medical University   School of Health Sciences   准教授  

Research Interests 【 display / non-display 】

Research Interests 【 display / non-display 】

• Cerebral artery

• endothelial function

• Flow mediated dilation

• Exercise program

• Blood flow

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Papers 【 display / non-display 】

Papers 【 display / non-display 】

• Acute aerobic exercise enhances cerebrovascular shear-mediated dilation in young adults: the role of cerebral shear.

  Rintaro Sakamoto, Tatsuki Kamoda, Kohei Sato, Shigehiko Ogoh, Masaki Katayose, Toru Neki, Erika Iwamoto

  Journal of applied physiology (Bethesda, Md. : 1985)   136 ( 3 ) 535 - 548  2024.03  [International journal]

  　View Summary

  Exercise-induced increases in shear rate (SR) acutely improve peripheral endothelial function, but the presence of this mechanism in cerebral arteries remains unclear. Thus, we evaluated shear-mediated dilation of the internal carotid artery (ICA), which is an index of cerebrovascular endothelial function, before and after exercise. Shear-mediated dilation was measured with 30 s of hypercapnia in 16 young adults before and 10 min after 30 min of sitting rest (CON) or three cycling exercises on four separate days. The target exercise intensity was 80% of oxygen uptake at the ventilatory threshold. To manipulate the ICA SR during exercise, participants breathed spontaneously (ExSB, SR increase) or hyperventilated without (ExHV, no increase in SR) or with ([Formula: see text], restoration of SR increase) addition of CO2 to inspiratory air. Shear-mediated dilation was calculated as a percent increase in diameter from baseline. Doppler ultrasound measures ICA velocity and diameter. The CON trial revealed that 30 min of sitting did not alter shear-mediated dilation (4.34 ± 1.37% to 3.44 ± 1.23%, P = 0.052). ICA dilation after exercise compared with preexercise levels increased in the ExSB trial (3.32 ± 1.37% to 4.74 ± 1.84%, P < 0.01), remained unchanged in the ExHV trial (4.07 ± 1.55% to 3.21 ± 1.48%, P = 0.07), but was elevated in the [Formula: see text] trial (3.35 ± 1.15% to 4.33 ± 2.12%, P = 0.04). Our results indicate that exercise-induced increases in cerebral shear may play a crucial role in improving cerebrovascular endothelial function after acute exercise in young adults.NEW & NOTEWORTHY We found that 30-min cycling (target intensity was 80% of the ventilatory threshold) with increasing shear of the internal carotid artery (ICA) enhanced transient hypercapnia-induced shear-mediated dilation of the ICA, reflecting improved cerebrovascular endothelial function. This enhancement of ICA dilation was diminished by suppressing the exercise-induced increase in ICA shear via hyperventilation. Our results indicate that increases in cerebral shear may be a key stimulus for improving cerebrovascular endothelial function after exercise in young adults.

  DOI PubMed

• Handgrip exercise does not alter CO₂‐mediated cerebrovascular flow‐mediated dilation

  Shotaro Saito, Hironori Watanabe, Erika Iwamoto, Shigehiko Ogoh

  Experimental Physiology ( Wiley )  108 ( 10 ) 1337 - 1346  2023.08  [International journal]

  　View Summary

  Abstract Handgrip exercise (HG), a small muscle exercise, improves cognitive function and is expected to provide a useful exercise mode to maintain cerebral health. However, the effect of HG on cerebral blood flow regulation is not fully understood. The present study aimed to examine the effect of acute HG on cerebral endothelial function as one of the essential cerebral blood flow regulatory functions. Thirteen healthy young participants performed interval HG, consisting of 4 sets of 2 min HG at 25% of maximum voluntary contraction with 3 min recovery between each set. Cognitive performance was evaluated before and at 5 and 60 min after interval HG using the Go/No‐Go task (reaction time and accuracy). The diameter and blood velocity of the internal carotid artery (ICA) were measured using a duplex Doppler ultrasound system. To assess cerebral endothelial function, hypercapnia (30 s of hypercapnia stimulation, end‐tidal partial pressure of CO₂: +9 mmHg)‐induced cerebrovascular flow‐mediated dilatation (cFMD) was induced, calculated as relative peak dilatation from baseline diameter. The shear rate (SR) was calculated using the diameter and blood velocity of the ICA. As a result, cognitive performance improved only at 5 min after interval HG (reaction time, P = 0.008; accuracy, P = 0.186), whereas ICA SR during interval HG and cFMD after interval HG were unchanged (P = 0.313 and P = 0.440, respectively). These results suggest that enhancement in cerebral endothelial function is not an essential mechanism responsible for acute HG‐induced cognitive improvement. New Findings What is the central question of this study? Does handgrip exercise, a small muscle exercise, improve cerebral endothelial function? What is the main finding and its importance? Acute interval isometric handgrip exercise (2 min of exercise at 25% maximum voluntary contraction, followed by 3 min of recovery, repeated for a total of 4 sets) did not improve cerebral endothelial function. Since the cerebrovascular shear rate did not change during exercise, it is possible that acute handgrip exercise is not sufficient stimulation to improve cerebral endothelial function.

  DOI PubMed

• Skipping breakfast does not accelerate the hyperglycemia-induced endothelial dysfunction but reduces blood flow of the brachial artery in young men.

  Tatsuki Kamoda, Rintaro Sakamoto, Masaki Katayose, Saki Yamamoto, Toru Neki, Kohei Sato, Erika Iwamoto

  European journal of applied physiology   124 ( 1 ) 295 - 308  2023.07  [Refereed]  [International journal]

  Authorship：   Last author  , Corresponding author

  　View Summary

  PURPOSE: Postprandial hyperglycemia is assumed to have a negative impact on flow-mediated dilation (FMD), an index of endothelial function, and blood flow of the peripheral conduit arteries. This study aimed to determine whether the enhancement of postprandial hyperglycemia by skipping breakfast accelerates endothelial dysfunction and reduces the blood flow in the brachial artery in young men. METHODS: Using a randomized cross-over design, ten healthy men completed two trials: with and without breakfast (Eating and Fasting trials, respectively). Venous blood sampling and brachial FMD tests were conducted before, 30, 60, 90, and 120 min after a 75-g oral glucose tolerance test (OGTT). RESULTS: Skipping breakfast boosted post-OGTT glucose levels than having breakfast (P = 0.01). The magnitude of the decrease in FMD via OGTT did not vary between trials (main effect of trial P = 0.55). Although brachial blood flow tended to decrease after OGTT in both trials (interaction and main effect of time P = 0.61 and P = 0.054, respectively), the decrease in blood flow following OGTT was greater in the Fasting trial than in the Eating trial (main effect of trial, mean difference =  - 15.8 mL/min [95%CI =  - 25.6 to - 6.0 mL/min], P < 0.01). CONCLUSION: Skipping breakfast did not enhance the magnitude of the decrease in FMD following glucose loading, but did accelerate hyperglycemia-induced reduction in brachial blood flow. Current findings suggest that even missing one breakfast has negative impacts on the blood flow regulation of the peripheral conduit arteries in young men who habitually eat breakfast.

  DOI PubMed

• 呼気終末二酸化炭素分圧の低下が内頸動脈の血流依存性血管拡張反応に与える影響

  坂本 琳太郎, 鴨田 樹, 佐藤 晃平, 片寄 正樹, 根木 亨, 岩本 えりか

  基礎理学療法学 ( (一社)日本基礎理学療法学会 )  25 ( Suppl.1 ) 89 - 89  2023.01

• Can alterations in cerebrovascular CO2 reactivity be identified using transfer function analysis without the requirement for carbon dioxide inhalation?

  Shigehiko Ogoh, Hironori Watanabe, Shotaro Saito, James Fisher, Erika Iwamoto

  Journal of Clinical Medicine ( MDPI AG )  12 ( 6 ) 2441 - 2441  2023  [International journal]

  Authorship：   Last author

  　View Summary

  The present study aimed to examine the validity of a novel method to assess cerebrovascular carbon dioxide (CO2) reactivity (CVR) that does not require a CO2 inhalation challenge, e.g., for use in patients with respiratory disease or the elderly, etc. In twenty-one healthy participants, CVR responses to orthostatic stress (50° head-up tilt, HUT) were assessed using two methods: (1) the traditional CO2 inhalation method, and (2) transfer function analysis (TFA) between middle cerebral artery blood velocity (MCA V) and predicted arterial partial pressure of CO2 (PaCO2) during spontaneous respiration. During HUT, MCA V steady-state (i.e., magnitude) and MCA V onset (i.e., time constant) responses to CO2 inhalation were decreased (p < 0.001) and increased (p = 0.001), respectively, indicative of attenuated CVR. In contrast, TFA gain in the very low-frequency range (VLF, 0.005–0.024 Hz) was unchanged, while the TFA phase in the VLF approached zero during HUT (−0.38 ± 0.59 vs. 0.31 ± 0.78 radians, supine vs. HUT; p = 0.003), indicative of a shorter time (i.e., improved) response of CVR. These findings indicate that CVR metrics determined by TFA without a CO2 inhalation do not track HUT-evoked reductions in CVR identified using CO2 inhalation, suggesting that enhanced cerebral blood flow response to a change in CO2 using CO2 inhalation is necessary to assess CVR adequately.

  DOI PubMed

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Misc 【 display / non-display 】

Misc 【 display / non-display 】

• Effect of Leg Cycling with Different Degrees of Blood Flow Restriction on Brachial Flow-Mediated Dilation

  水野沙洸, 石田浩司, 齊藤満, 岩本えりか, 片山敬章

  デサントスポーツ科学   43  2022

  J-GLOBAL

• Effect of cigarette smoking on hypercapnia induced shear-mediated dilation in the internal carotid artery

  Kazuya Suzuki, Takuro Washio, Shingo Tsukamoto, Kazunori Kato, Erika Iwamoto, Shigehiko Ogoh

  FASEB JOURNAL ( WILEY )  33  2019.04

  Research paper, summary (international conference)  

  　View Summary

  0

• Respiratory Muscle Endurance And Cardiovascular Response To Hyperpnoea After Respiratory Muscle Training In Hypoxia

  Keisho Katayama, Erika Iwamoto, Toshiyuki Ohya, Kazushige Goto, Kenji Takao, Nobukazu Kasai, Daichi Sumi, Koji Ishida, Yasuhiro Suzuki

  MEDICINE AND SCIENCE IN SPORTS AND EXERCISE ( LIPPINCOTT WILLIAMS & WILKINS )  49 ( 5 ) 796 - 796  2017.05

  Research paper, summary (international conference)  

  DOI

• Combined Effect of Heating and Electrical Stimulation on Endothelial Vasodilator Function

  Erika Iwamoto, Shotaro Oiwa, Jiro Takami, Ryohei Nagaoka, Shota Ito, Toru Neki, Masaki Katayose

  FASEB JOURNAL ( FEDERATION AMER SOC EXP BIOL )  31  2017.04

  Research paper, summary (international conference)  

• Effects of acute electric stimulation on flow-mediated vasomotor function

  Shotaro Oiwa, Erika Iwamoto, Ryohei Nagaoka, Shota Ito, Jiro Takami, Toru Neki, Masaki Katayose

  Rigakuryoho Kagaku ( Society of Physical Therapy Science (Rigaku Ryoho Kagakugakkai) )  32 ( 2 ) 249 - 254  2017

  　View Summary

  [Purpose] The aim of the present study was to investigate the effects of acute electric stimulation on flow-mediated vasomotor function. [Subjects and Methods] Eight young healthy men participated in this study. Electrical stimulation was applied to the right forearm for 30 minutes. Before and after electrical stimulation, flow-mediated dilation (FMD) and low flow-mediated constriction (L-FMC) were measured at the right brachial artery. [Results] FMD and L-FMC tended to increase after electrical stimulation, but no significant differences were observed between pre- and post-stimulation. In contrast, FMD+L-FMC significantly increased after electrical stimulation compared to before stimulation. [Conclusion] These results suggest that acute electric stimulation affects flow-mediated vasoconstrictor and dilator functions. Further studies are needed to elucidate the effect of electrical parameter settings on the vascular function.

  DOI CiNii

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Awards 【 display / non-display 】

Awards 【 display / non-display 】

• 最優秀若手演題賞

  2022.11   日本血管血流学会  

  Winner： 坂本琳太郎 (指導教員 岩本えりか)

• John F. Perkins, Jr. Memorial Award for International Physiologists

  2019.06   American Physiological Society  

  Winner： IWAMOTO Erika

• International Early Career Physiologist Travel Award

  2018.04   American Physiological Society  

  Winner： IWAMOTO Erika

• 最優秀演題賞

  2015.11   日本血管血流学会  

  Winner： 岩本えりか

Research Projects 【 display / non-display 】

Research Projects 【 display / non-display 】

• 糖尿病患者におけるレジスタンス運動中の眼圧上昇を防ぐ新規介入方策の開発

  挑戦的研究(萌芽)

  Project Year :

  2024.06

  -

  2027.03

   

  岩本 えりか, 片山 敬章, 小河 繁彦

• 心不全の治療経過に着目したサルコペニアの発症・進行因子の解明

  基盤研究(C)

  Project Year :

  2024.04

  -

  2027.03

   

  山田 悠, 角谷 尚哉, 岩本 えりか, 片寄 正樹

• Comparative Analysis of Cerebral and Peripheral Circulatory Function, Exercise Pressor Response, and Brain Anatomical Characteristics Between Japanese and Caucasian Americans

  Fund for the Promotion of Joint International Research (International Collaborative Research)

  Project Year :

  2023.09

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  2029.03

   

  小河 繁彦, 菅原 順, 岩本 えりか, 樽味 孝, 塚本 敏人

• Effect of the response of shear rate in the cerebral artery to exercise on cerebral endothelial function and cognitive function

  Grant-in-Aid for Scientific Research (B)

  Project Year :

  2022.04

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  2026.03

   

  小河 繁彦, 岩本 えりか, 橋本 健志

• Cardiopulmonary baroreflex control of arterial blood pressure during exercise in the elderly

  Grant-in-Aid for Scientific Research (B)

  Project Year :

  2022.04

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  2025.03

   

  片山 敬章, 岩本 えりか, 石田 浩司, 小河 繁彦

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Social Activities 【 display / non-display 】

Social Activities 【 display / non-display 】

• Review Editor, Frontiers in Physiology

  2022.06

  　

  　

• Reviewer, Journal of Applied Physiology

  2019.03

  　

  　

• Reviewer, Clinical Physiology and Functional Imaging

• Reviewer, Physiological Reports

• Reviewer, The Journal of Physiological Sciences

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