岩本 えりか (イワモト エリカ)

写真a

所属

保健医療学部 理学療法学科 理学療法学第二講座

職名

准教授

ホームページ

http://kaken.nii.ac.jp/d/r/40632782.ja.html

学歴 【 表示 / 非表示

  • 2010年
    -
    2013年

    名古屋大学   医学系研究科 短縮修了(医学博士)  

  • 2008年
    -
    2010年

    広島大学   保健学研究科 修了(保健学修士)  

学位 【 表示 / 非表示

  • 名古屋大学   博士(医学)

経歴 【 表示 / 非表示

  • 2024年04月
    -
    継続中

    札幌医科大学 保健医療学部 理学療法学科   准教授

  • 2020年04月
    -
    2024年03月

    札幌医科大学 保健医療学部 理学療法学科   School of Health Sciences   講師

  • 2019年10月
    -
    2019年12月

    University of Iowa, Human Integrative and Cardiovascular Physiology Laboratory  

  • 2016年09月
    -
    2017年09月

    University of Iowa   Human Integrative and Cardiovascular Physiology Laboratory  

  • 2013年04月
    -
    2020年03月

    札幌医科大学 保健医療学部 理学療法学科   助教

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所属学協会 【 表示 / 非表示

  •  
     
     

    日本理学療法士協会

  •  
     
     

    日本体力医学会

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    日本基礎理学療法学会

  •  
     
     

    American Physiological Society

  •  
     
     

    American College of Sports Medicine

研究分野 【 表示 / 非表示

  • ライフサイエンス   スポーツ科学  

  • ライフサイエンス   リハビリテーション科学  

researchmapの所属 【 表示 / 非表示

  • University of Iowa / Human Integrative and Cardiovascular Physiology Laboratory   Visiting scholar  

  • 札幌医科大学   保健医療学部   准教授  

 

研究キーワード 【 表示 / 非表示

  • 脳血管

  • 血管内皮機能

  • 血流依存性血管拡張

  • 運動療法

  • 血流調節

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論文 【 表示 / 非表示

  • Effects of inspiratory muscle metaboreflex on cerebral circulation at rest and during light-intensity exercise in healthy males.

    Kohei Sato, Tatsuki Kamoda, Rintaro Sakamoto, Keisho Katayama, Toru Neki, Masaki Katayose, Erika Iwamoto

    Respiratory physiology & neurobiology     104422 - 104422  2025年03月  [国際誌]

    担当区分:   最終著者  , 責任著者

     概要を見る

    PURPOSE: This study aimed to clarify the effects of inspiratory muscle metaboreflex on cerebral circulation at rest and during exercise. METHODS: Twelve young males randomly completed two trials (rest and exercise [leg cycling at 40% peak oxygen uptake] trials) on separate days. In each trial, the internal carotid artery (ICA), an index of cerebral circulation, was measured using Doppler ultrasound 2min after inspiratory loading breathing (IL condition) or non-loading breathing (control condition). During ICA assessments, participants engaged in 3min of spontaneous breathing (SB), followed by 3min of isocapnic hyperventilation (IHV). RESULTS: ICA conductance was lower in the IL condition than in the control condition in both rest and exercise trials. Inspiratory mucle metaboreflex did not reduce ICA blood flow during SB but decreased it during IHV in both trials. CONCLUSION: Our findings suggest that inspiratory muscle metaboreflex could decrease cerebrovascular conductance from rest to light-intensity exercise and attenuates cerebral blood flow with increased respiratory muscle work.

    DOI PubMed

  • Dilatory responsiveness of the internal carotid artery to shear stimulus is constant under different levels of transient hypercapnia.

    Rintaro Sakamoto, Tatsuki Kamoda, Shigehiko Ogoh, Kohei Sato, Masaki Katayose, Toru Neki, Erika Iwamoto

    Journal of applied physiology (Bethesda, Md. : 1985)   138 ( 2 ) 397 - 403  2025年02月  [国際誌]

    担当区分:   最終著者  , 責任著者

     概要を見る

    Peripheral endothelial function, which accounts for the variability in shear stimulus, can be assessed using shear-mediated dilation normalized to the increased shear stimulus. Similarly, shear-mediated dilation of the internal carotid artery (ICA), an index of cerebrovascular endothelial function, should be normalized to increased shear stimulus. However, this approach has not yet been validated. Thus, the shear-mediated dilation of the ICA was assessed in 14 young adults during three levels of transient hypercapnia, induced by elevating the partial pressure of end-tidal carbon dioxide for 30 s by 6, 9, and 12 mmHg. The ICA shear rate (SR) was calculated using the ICA diameter and velocity, both measured by Doppler ultrasound. The total vasodilator stimulus was quantified as the SR area under the curve from the onset of hypercapnia to peak dilation, including and excluding baseline values [(SRAUC) and delta SRAUC (DSRAUC), respectively]. Shear-mediated dilation was calculated as the percent increase in diameter from baselines. ICA dilation was positively associated with DSRAUC [r(rm) = 0.47, P < 0.01] but not with SRAUC [r(rm) = 0.32, P = 0.09]. Consequently, ICA dilation normalized to DSRAUC did not differ among trials (main effect of rial, P = 0.77). Contrarily, the difference in ICA dilation among trials remained significant when normalized to SRAUC (main effect of trial, P = 0.02). Therefore, normalized shear-mediated dilation using DSRAUC can reduce variability associated with increased shear stimulus during ICA dilation assessment, thereby enhancing the validity of evaluating cerebrovascular endothelial function.NEW & NOTEWORTHY This study demonstrated that shear-mediated dilation of the internal carotid artery (ICA), an index of cerebrovascular endothelial function, increased with the increase of shear stimulus induced by different degrees of transient hypercapnia. However, when ICA dilation was normalized to the total increased shear stimulus above baseline, the vasodilation became comparable across different hypercapnia levels. Thus, normalizing ICA dilation to the total shear stimulus increased from baseline may enhance the validity of assessing cerebrovascular endothelial function.

    DOI PubMed

  • Prolonged sitting is not associated with altered shear-mediated dilation of the internal carotid artery, despite impairing lower limb endothelial function.

    Shotaro Saito, Kento Dora, Marino Karaki, Narumi Kunimatsu, Hayato Tsukamoto, Jun Sugawara, Erika Iwamoto, Shigehiko Ogoh

    Physiological reports   13 ( 3 ) e70097  2025年02月  [国際誌]

     概要を見る

    The present study aims to examine the effect of 4 h of continuous sitting on cerebral endothelial function, which is a crucial component of cerebral blood flow regulation. We hypothesized that 4 h of sitting may impair cerebral endothelial function similarly to how it affects lower limb vasculature. Thirteen young, healthy participants were instructed to remain seated for 4 h without moving their lower limbs. The blood flow and shear rate (SR) in the popliteal and internal carotid artery (ICA) were measured using duplex Doppler ultrasound. During the 4-h sitting, peripheral (popliteal artery) and cerebral (ICA) endothelial function were assessed every hour. We induced peripheral and cerebral flow-mediated dilation (pFMD and ICA FMD) using hyperemia (5 min of cuff inflation on lower limb, then deflation) or hypercapnia (30s of hypercapnia, end-tidal partial pressure of CO2 + 9 mmHg), respectively. We then calculated each relative peak dilation from the baseline diameter to identify both pFMD and ICA FMD. We observed a significant decrease in pFMD starting at 2 h from the onset of sitting, and this reduction persisted throughout the 4-h sitting [Base (6.8 ± 4.2%) vs. 2-h (3.9 ± 2.0%), p = 0.044; vs. 3-h (3.2 ± 1.8%), p = 0.016; vs. 4-h (3.2 ± 1.9%), p = 0.005]. In contrast, during the 4-h sitting, ICA blood flow, SR, and ICA FMD remained unchanged (p = 0.062, p = 0.068, and p = 0.203, respectively). Unlike peripheral endothelial function, cerebral endothelial function remained stable during 4-h sitting. This suggests that the acute effect of prolonged sitting on cerebral vasculature differs from that of lower limb vasculature.

    DOI PubMed

  • inhibition of sympathetic vasomotor outflow during low-intensity leg cycling is attenuated in heathy older females

    Katayama K., Shiozawa K., Ishida K., Banno R., Kinoshita A., Iwamoto E., Ogoh S.

    J. Appl. Physiol.   - In press  2025年

  • Acute aerobic exercise enhances cerebrovascular shear-mediated dilation in young adults: the role of cerebral shear.

    Rintaro Sakamoto, Tatsuki Kamoda, Kohei Sato, Shigehiko Ogoh, Masaki Katayose, Toru Neki, Erika Iwamoto

    Journal of applied physiology (Bethesda, Md. : 1985)   136 ( 3 ) 535 - 548  2024年03月  [国際誌]

    担当区分:   最終著者  , 責任著者

     概要を見る

    Exercise-induced increases in shear rate (SR) acutely improve peripheral endothelial function, but the presence of this mechanism in cerebral arteries remains unclear. Thus, we evaluated shear-mediated dilation of the internal carotid artery (ICA), which is an index of cerebrovascular endothelial function, before and after exercise. Shear-mediated dilation was measured with 30 s of hypercapnia in 16 young adults before and 10 min after 30 min of sitting rest (CON) or three cycling exercises on four separate days. The target exercise intensity was 80% of oxygen uptake at the ventilatory threshold. To manipulate the ICA SR during exercise, participants breathed spontaneously (ExSB, SR increase) or hyperventilated without (ExHV, no increase in SR) or with ([Formula: see text], restoration of SR increase) addition of CO2 to inspiratory air. Shear-mediated dilation was calculated as a percent increase in diameter from baseline. Doppler ultrasound measures ICA velocity and diameter. The CON trial revealed that 30 min of sitting did not alter shear-mediated dilation (4.34 ± 1.37% to 3.44 ± 1.23%, P = 0.052). ICA dilation after exercise compared with preexercise levels increased in the ExSB trial (3.32 ± 1.37% to 4.74 ± 1.84%, P < 0.01), remained unchanged in the ExHV trial (4.07 ± 1.55% to 3.21 ± 1.48%, P = 0.07), but was elevated in the [Formula: see text] trial (3.35 ± 1.15% to 4.33 ± 2.12%, P = 0.04). Our results indicate that exercise-induced increases in cerebral shear may play a crucial role in improving cerebrovascular endothelial function after acute exercise in young adults.NEW & NOTEWORTHY We found that 30-min cycling (target intensity was 80% of the ventilatory threshold) with increasing shear of the internal carotid artery (ICA) enhanced transient hypercapnia-induced shear-mediated dilation of the ICA, reflecting improved cerebrovascular endothelial function. This enhancement of ICA dilation was diminished by suppressing the exercise-induced increase in ICA shear via hyperventilation. Our results indicate that increases in cerebral shear may be a key stimulus for improving cerebrovascular endothelial function after exercise in young adults.

    DOI PubMed

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Misc 【 表示 / 非表示

  • 血流制限下での有酸素性運動の効果:血管内皮機能への影響を考慮した至適プロトコルの探索

    水野沙洸, 石田浩司, 齊藤満, 岩本えりか, 片山敬章

    デサントスポーツ科学   43  2022年

    J-GLOBAL

  • Effect of cigarette smoking on hypercapnia induced shear-mediated dilation in the internal carotid artery

    Kazuya Suzuki, Takuro Washio, Shingo Tsukamoto, Kazunori Kato, Erika Iwamoto, Shigehiko Ogoh

    FASEB JOURNAL ( WILEY )  33  2019年04月

    研究発表ペーパー・要旨(国際会議)  

     概要を見る

    0

  • Respiratory Muscle Endurance And Cardiovascular Response To Hyperpnoea After Respiratory Muscle Training In Hypoxia

    Keisho Katayama, Erika Iwamoto, Toshiyuki Ohya, Kazushige Goto, Kenji Takao, Nobukazu Kasai, Daichi Sumi, Koji Ishida, Yasuhiro Suzuki

    MEDICINE AND SCIENCE IN SPORTS AND EXERCISE ( LIPPINCOTT WILLIAMS & WILKINS )  49 ( 5 ) 796 - 796  2017年05月

    研究発表ペーパー・要旨(国際会議)  

    DOI

  • Combined Effect of Heating and Electrical Stimulation on Endothelial Vasodilator Function

    Erika Iwamoto, Shotaro Oiwa, Jiro Takami, Ryohei Nagaoka, Shota Ito, Toru Neki, Masaki Katayose

    FASEB JOURNAL ( FEDERATION AMER SOC EXP BIOL )  31  2017年04月

    研究発表ペーパー・要旨(国際会議)  

  • 急性の電気刺激が血流依存性の血管調節機能に与える影響

    大岩 正太郎, 岩本 えりか, 長岡 凌平, 伊藤 翔太, 高見 次郎, 根木 亨, 片寄 正樹

    理学療法科学 ( 理学療法科学学会 )  32 ( 2 ) 249 - 254  2017年

     概要を見る

    〔目的〕血管内皮機能の指標である血流依存性血管拡張反応(以下,FMD)および低血流依存性血管収縮反応(以下,L-FMC)に着目し, 急性的な電気刺激が血流依存性の血管調節機能に与える影響を明らかにすることを目的とした.〔対象と方法〕健常成人男性8名.被験者の右前腕に対して30分間の電気刺激介入を行い, 介入前後で右上腕動脈のFMDおよびL-FMCを測定し,介入前後で比較した.〔結果〕FMDとL-FMCは介入により増加を示したが有意差は認めなかった.一方,FMD+L-FMCは介入前と比較して介入後に有意に増加を示した.〔結語〕急性的な筋への電気刺激は血流依存性の血管収縮・拡張能に影響を与える可能性があるが,今後電気刺激の設定について更なる検討が必要である.

    DOI CiNii

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受賞 【 表示 / 非表示

  • 最優秀若手演題賞

    2022年11月   日本血管血流学会  

    受賞者: 坂本琳太郎 (指導教員 岩本えりか)

  • John F. Perkins, Jr. Memorial Award for International Physiologists

    2019年06月   アメリカ生理学会  

    受賞者: 岩本えりか

  • International Early Career Physiologist Travel Award

    2018年04月   アメリカ生理学会  

    受賞者: 岩本えりか

  • 最優秀演題賞

    2015年11月   日本血管血流学会  

    受賞者: 岩本えりか

共同研究・競争的資金等の研究課題 【 表示 / 非表示

  • 糖尿病患者におけるレジスタンス運動中の眼圧上昇を防ぐ新規介入方策の開発

    挑戦的研究(萌芽)

    研究期間:

    2024年06月
    -
    2027年03月
     

    岩本 えりか, 片山 敬章, 小河 繁彦

  • 心不全の治療経過に着目したサルコペニアの発症・進行因子の解明

    基盤研究(C)

    研究期間:

    2024年04月
    -
    2027年03月
     

    山田 悠, 角谷 尚哉, 岩本 えりか, 片寄 正樹

  • 体・脳循環機能とその運動昇圧応答及び脳解剖学的特性の日本人と白人米国人との差異

    国際共同研究加速基金(海外連携研究)

    研究期間:

    2023年09月
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    2029年03月
     

    小河 繁彦, 菅原 順, 岩本 えりか, 樽味 孝, 塚本 敏人

  • 運動による脳血管シェアレイト応答が脳内皮機能や認知機能に及ぼす影響

    基盤研究(B)

    研究期間:

    2022年04月
    -
    2026年03月
     

    小河 繁彦, 岩本 えりか, 橋本 健志

  • 高齢者における運動時の過剰昇圧応答に対する心肺圧受容器反射の役割の解明

    基盤研究(B)

    研究期間:

    2022年04月
    -
    2025年03月
     

    片山 敬章, 岩本 えりか, 石田 浩司, 小河 繁彦

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社会貢献活動 【 表示 / 非表示

  • Review Editor, Frontiers in Physiology

    2022年06月
     
     

  • Reviewer, Journal of Applied Physiology

    2019年03月
     
     

  • Reviewer, Clinical Physiology and Functional Imaging

  • Reviewer, Physiological Reports

  • Reviewer, The Journal of Physiological Sciences

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