NAKANO Masako

写真a

Affiliation

School of Medicine, Department of Anatomy (2)

Job title

Lecturer
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Education 【 display / non-display 】

  • 2002
    -
    2008

    鹿児島大学医学部医学科  

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Degree 【 display / non-display 】

  • 医学博士

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Research Experience 【 display / non-display 】

  • 2021.06
    -
    Now

    札幌医科大学解剖学第２講座   講師

  • 2013.04
    -
    2021.05

    札幌医科大学解剖学第２講座   助教

  • 2012.04
    -
    2013.03

    札幌医科大学解剖学第２講座（特別研究生）  

  • 2011.04
    -
    2012.03

    鹿児島大学心身医療科（医員）  

  • 2010.07
    -
    2011.03

    鹿児島共済会南風病院（後期研修医）  

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Research Areas 【 display / non-display 】

  • Life sciences   Neuroscience - general  

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Affiliation 【 display / non-display 】

  • Sapporo Medical University   解剖学第２講座  

  • Sapporo Medical University   神経内科学講座  

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Papers 【 display / non-display 】

  • Potential effects of mesenchymal stem cell derived extracellular vesicles and exosomal miRNAs in neurological disorders.

    Masako Nakano, Mineko Fujimiya

    Neural regeneration research   16 ( 12 ) 2359 - 2366  2021.12  [Refereed]  [International journal]

    Authorship：   Lead author  , Corresponding author

    　View Summary

    Mesenchymal stem cells are multipotent cells that possess anti-inflammatory, anti-apoptotic and immunomodulatory properties. The effects of existing drugs for neurodegenerative disorders such as Alzheimer's disease are limited, thus mesenchymal stem cell therapy has been anticipated as a means of ameliorating neuronal dysfunction. Since mesenchymal stem cells are known to scarcely differentiate into neuronal cells in damaged brain after transplantation, paracrine factors secreted from mesenchymal stem cells have been suggested to exert therapeutic effects. Extracellular vesicles and exosomes are small vesicles released from mesenchymal stem cells that contain various molecules, including proteins, mRNAs and microRNAs. In recent years, administration of exosomes/extracellular vesicles in models of neurological disorders has been shown to improve neuronal dysfunctions, via exosomal transfer into damaged cells. In addition, various microRNAs derived from mesenchymal stem cells that regulate various genes and reduce neuropathological changes in various neurological disorders have been identified. This review summarizes the effects of exosomes/extracellular vesicles and exosomal microRNAs derived from mesenchymal stem cells on models of stroke, subarachnoid and intracerebral hemorrhage, traumatic brain injury, and cognitive impairments, including Alzheimer's disease.

    DOI PubMed

  • Mindfulness intervention improves cognitive function in older adults by enhancing the level of miRNA-29c in neuron-derived extracellular vesicles.

    Shin Hashizume, Masako Nakano, Kenta Kubota, Seiichi Sato, Nobuaki Himuro, Eiji Kobayashi, Akinori Takaoka, Mineko Fujimiya

    Scientific reports   11 ( 1 ) 21848 - 21848  2021.11  [Refereed]  [International journal]

    Authorship：   Corresponding author

    　View Summary

    Although mindfulness-based stress reduction (MBSR) improves cognitive function, the mechanism is not clear. In this study, people aged 65 years and older were recruited from elderly communities in Chitose City, Japan, and assigned to a non-MBSR group or a MBSR group. Before and after the intervention, the Japanese version of the Montreal Cognitive Assessment (MoCA-J) was administered, and blood samples were collected. Then, neuron-derived extracellular vesicles (NDEVs) were isolated from blood samples, and microRNAs, as well as the target mRNAs, were evaluated in NDEVs. A linear mixed model analysis showed significant effects of the MBSR x time interaction on the MoCA-J scores, the expression of miRNA(miR)-29c, DNA methyltransferase 3 alpha (DNMT3A), and DNMT3B in NDEVs. These results indicate that MBSR can improve cognitive function by increasing the expression of miR-29c and decreasing the expression of DNMT3A, as well as DNMT3B, in neurons. It was also found that intracerebroventricular injection of miR-29c mimic into 5xFAD mice prevented cognitive decline, as well as neuronal loss in the subiculum area, by down-regulating Dnmt3a  and Dnmt3b  in the hippocampus. The present study suggests that MBSR can prevent neuronal loss and cognitive impairment by increasing the neuronal expression of miR-29c.

    DOI PubMed

  • 研究者の最新動向 アルツハイマー病理変化と症状が乖離する例における認知症発症予防の機序

    小林 英司, 中野 正子, 藤宮 峯子

    Precision Medicine ( (株)北隆館 )  4 ( 5 ) 480 - 485  2021.05

    　View Summary

    アルツハイマー型認知症(Alzheimer's Disease:AD)の基本的な病理変化であるAβプラークとタウが脳内に明らかに蓄積していたにも関わらず、生前に認知症を発症しなかった例が相当数存在することが複数の死後脳研究で報告されている。しかし、その発症予防メカニズムは未だ明らかになっていない。本稿では、AD病理と認知症状の乖離についての過去の報告を概説し、死後脳研究による自験例をもとにAD病理変化と症状の乖離する例におけるアストロサイトの神経保護作用について解説し、Aβプラークやタウが蓄積した脳における認知症発症予防のメカニズムについて議論したい。(著者抄録)

  • Author Correction: Umbilical cord extracts improve osteoporotic abnormalities of bone marrow-derived mesenchymal stem cells and promote their therapeutic effects on ovariectomised rats (Scientific Reports, (2018), 8, 1, (1161), 10.1038/s41598-018-19516-6)

    Akira Saito, Kanna Nagaishi, Kousuke Iba, Yuka Mizue, Takako Chikenji, Miho Otani, Masako Nakano, Kazusa Oyama, Toshihiko Yamashita, Mineko Fujimiya

    Scientific Reports ( Nature Research )  10 ( 1 )  2020.12

    　View Summary

    This Article contains errors. As a result of a figure assembly error, Figure 3C panel None/WJ(+) is a duplication of panel SDF-1/WJ(−). The correct Figure 3 appears below as Figure 1. This change does not affect the conclusions of the Article.

    DOI PubMed

  • An enriched environment prevents cognitive impairment in an Alzheimer’s disease model by enhancing the secretion of exosomal microRNA-146a from the choroid plexus

    Masako Nakano, Kenta Kubota, Shin Hashizume, Eiji Kobayashi, Takako S. Chikenji, Yuki Saito, Mineko Fujimiya

    Brain, Behavior, & Immunity - Health ( Elsevier BV )  9   100149 - 100149  2020.10  [Refereed]

    Authorship：   Lead author  , Corresponding author

    DOI

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Misc 【 display / non-display 】

  • 献体脳におけるアルツハイマー病理と認知機能に関する研究

    中野 正子, 小林 英司, 永石 歓和, 久原 真, 藤宮 峯子

    臨床神経学 ( (一社)日本神経学会 )  64 ( 6 ) 431 - 431  2024.06

  • 三次元培養した骨髄間葉系幹細胞のアルツハイマー型認知症モデルマウスへの効果

    中野正子, 橋爪紳, 木原花野, 藤宮峯子, 藤宮峯子

    日本再生医療学会総会(Web)   23rd  2024

    J-GLOBAL

  • アルツハイマー病理陽性で認知機能が正常であった症例における脈絡叢の解析

    中野正子, 小林英司, 小林英司, 橋爪紳, 藤宮峯子

    日本解剖学会総会・全国学術集会講演プログラム・抄録集   127th  2022

    J-GLOBAL

  • 骨髄間葉系幹細胞はmiR-146aを内包するエクソソームを分泌しアルツハイマー病マウスの認知障害を改善させる

    中野正子, 久保田健太, 小林英司, 千見寺貴子, 齋藤悠城, 小成直人, 藤宮峯子

    日本再生医療学会総会(Web)   19th  2020

    J-GLOBAL

  • 刺激豊かな環境での飼育がアルツハイマー病モデルマウスに与える影響の解析

    中野 正子, 小林 英司, 久保田 健太, 大谷 美穂, 千見寺 貴子, 水江 由佳, 永石 歓和, 藤宮 峯子

    Dementia Japan ( (一社)日本認知症学会 )  31 ( 4 ) 573 - 573  2017.10

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Research Projects 【 display / non-display 】

  • 認知機能に有効なmiRNAを内包する間葉系幹細胞由来エクソソームの開発―多孔質担体を用いた検討―

    Project Year :

    2024.04
    -
    2025.03
     

    中野 正子

    Authorship： Principal investigator

  • アルツハイマー病理に抗する認知症予防法と機序解明―献体脳を用いた前向き研究

    基盤研究(C)

    Project Year :

    2022.04
    -
    2025.03
     

    中野 正子, 小林 英司, 橋爪 紳, 久保田 健太, 藤宮 峯子

  • 献体脳のアルツハイマー病理から考える認知症治療の開発研究

    Project Year :

    2021.09
    -
    2022.03
     

    中野 正子

  • 死後脳のアルツハイマー病理と生前認知機能から考える認知症発症抑制メカニズムの解明

    Project Year :

    2020.07
    -
    2021.03
     

    中野 正子

  • マインドフルネスによる認知症発症抑制と血中microRNAの変化についての検討

    Project Year :

    2019.04
    -
    2022.03
     

    中野 正子

    Authorship： Principal investigator

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