Updated on 2025/08/22

写真a

 
NAKANO Masako
 
Organization
School of Medicine Department of Anatomy (2) Lecturer
Title
Lecturer
External link

Degree

  • 医学博士

Research Areas

  • Life Science / Neuroscience-general

Education

  • 鹿児島大学医学部医学科

    2002.4 - 2008.3

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Research History

  • 札幌医科大学解剖学第２講座   講師

    2021.6

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  • 札幌医科大学解剖学第２講座   助教

    2013.4 - 2021.5

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  • 札幌医科大学解剖学第２講座（特別研究生）

    2012.4 - 2013.3

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  • 鹿児島大学心身医療科（医員）

    2011.4 - 2012.3

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  • 鹿児島共済会南風病院（後期研修医）

    2010.7 - 2011.3

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  • 鹿児島医療センター（後期研修医）

    2010.4 - 2010.6

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  • 鹿児島大学病院（初期研修医）

    2008.4 - 2010.3

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Papers

  • Self-suppressing behavioral patterns and depressive traits exacerbate chronic pain: Psychological trait assessment using the structured association technique method. International journal

    Shin Hashizume, Masako Nakano, Chihiro Ikehata, Nobuaki Himuro, Kanna Nagaishi, Mineko Fujimiya

    PloS one   20 ( 3 )   e0319647   2025

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    Language：English   Publishing type：Research paper (scientific journal)  

    This study investigated the relationship between psychological traits and chronic pain using the Structured Association Technique (SAT) method to evaluate psychological factors associated with chronic pain. The participants included 105 older adults (23 men, 82 women, mean age 80.82 years) who received rehabilitation services. Chronic pain severity was assessed using a numerical rating scale (NRS), and psychological traits were evaluated by SAT. In addition, maternal attachment experiences in childhood were examined. The NRS showed significant positive correlations with the self-suppressing behavioral pattern (S) scale (r =  0.31, p =  0.001), and the depression (D) scale (r =  0.31, p =  0.001). The proportion of participants with high scores on both the S and D scales (SD group) was notably higher in the high NRS group. Logistic regression analysis showed that the SD group had a higher odds ratio (OR =  8.469, p =  0.004) for severe chronic pain, suggesting that SD traits independently contribute to worse pain. In the SD group, the self-denial scale scores were high, and self-denial traits showed a negative correlation with maternal attachment experiences in childhood. This finding indicates that poor maternal attachment may enhance self-denial traits, which in turn indirectly worsen pain through their effects on S and D traits. The results of this study highlight the importance of S and D traits as psychological factors in chronic pain, particularly in Japanese populations, and suggest that assessing self-suppressing behavioral patterns may be beneficial for pain management. However, the cross-cultural validity of the SAT scales requires further investigation. SAT therapy may provide a comprehensive approach to the treatment and prevention of complex conditions influenced by psychological and social factors, including chronic pain.

    DOI： 10.1371/journal.pone.0319647

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  • 献体脳におけるアルツハイマー病理と認知機能に関する研究

    中野 正子, 小林 英司, 永石 歓和, 久原 真, 藤宮 峯子

    臨床神経学   64 ( 6 )   431 - 431   2024.6

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    Language：Japanese   Publisher：(一社)日本神経学会  

    Ichushi

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  • Potential effects of mesenchymal stem cell derived extracellular vesicles and exosomal miRNAs in neurological disorders. Reviewed International journal

    Masako Nakano, Mineko Fujimiya

    Neural regeneration research   16 ( 12 )   2359 - 2366   2021.12

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    Authorship：Lead author,　Corresponding author   Language：English   Publishing type：Research paper (scientific journal)  

    Mesenchymal stem cells are multipotent cells that possess anti-inflammatory, anti-apoptotic and immunomodulatory properties. The effects of existing drugs for neurodegenerative disorders such as Alzheimer's disease are limited, thus mesenchymal stem cell therapy has been anticipated as a means of ameliorating neuronal dysfunction. Since mesenchymal stem cells are known to scarcely differentiate into neuronal cells in damaged brain after transplantation, paracrine factors secreted from mesenchymal stem cells have been suggested to exert therapeutic effects. Extracellular vesicles and exosomes are small vesicles released from mesenchymal stem cells that contain various molecules, including proteins, mRNAs and microRNAs. In recent years, administration of exosomes/extracellular vesicles in models of neurological disorders has been shown to improve neuronal dysfunctions, via exosomal transfer into damaged cells. In addition, various microRNAs derived from mesenchymal stem cells that regulate various genes and reduce neuropathological changes in various neurological disorders have been identified. This review summarizes the effects of exosomes/extracellular vesicles and exosomal microRNAs derived from mesenchymal stem cells on models of stroke, subarachnoid and intracerebral hemorrhage, traumatic brain injury, and cognitive impairments, including Alzheimer's disease.

    DOI： 10.4103/1673-5374.313026

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  • Mindfulness intervention improves cognitive function in older adults by enhancing the level of miRNA-29c in neuron-derived extracellular vesicles. Reviewed International journal

    Shin Hashizume, Masako Nakano, Kenta Kubota, Seiichi Sato, Nobuaki Himuro, Eiji Kobayashi, Akinori Takaoka, Mineko Fujimiya

    Scientific reports   11 ( 1 )   21848 - 21848   2021.11

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    Authorship：Corresponding author   Language：English   Publishing type：Research paper (scientific journal)  

    Although mindfulness-based stress reduction (MBSR) improves cognitive function, the mechanism is not clear. In this study, people aged 65 years and older were recruited from elderly communities in Chitose City, Japan, and assigned to a non-MBSR group or a MBSR group. Before and after the intervention, the Japanese version of the Montreal Cognitive Assessment (MoCA-J) was administered, and blood samples were collected. Then, neuron-derived extracellular vesicles (NDEVs) were isolated from blood samples, and microRNAs, as well as the target mRNAs, were evaluated in NDEVs. A linear mixed model analysis showed significant effects of the MBSR x time interaction on the MoCA-J scores, the expression of miRNA(miR)-29c, DNA methyltransferase 3 alpha (DNMT3A), and DNMT3B in NDEVs. These results indicate that MBSR can improve cognitive function by increasing the expression of miR-29c and decreasing the expression of DNMT3A, as well as DNMT3B, in neurons. It was also found that intracerebroventricular injection of miR-29c mimic into 5xFAD mice prevented cognitive decline, as well as neuronal loss in the subiculum area, by down-regulating Dnmt3a  and Dnmt3b  in the hippocampus. The present study suggests that MBSR can prevent neuronal loss and cognitive impairment by increasing the neuronal expression of miR-29c.

    DOI： 10.1038/s41598-021-01318-y

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  • 研究者の最新動向 アルツハイマー病理変化と症状が乖離する例における認知症発症予防の機序

    小林 英司, 中野 正子, 藤宮 峯子

    Precision Medicine   4 ( 5 )   480 - 485   2021.5

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    Language：Japanese   Publisher：(株)北隆館  

    Ichushi

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  • Author Correction: Umbilical cord extracts improve osteoporotic abnormalities of bone marrow-derived mesenchymal stem cells and promote their therapeutic effects on ovariectomised rats (Scientific Reports, (2018), 8, 1, (1161), 10.1038/s41598-018-19516-6)

    Akira Saito, Kanna Nagaishi, Kousuke Iba, Yuka Mizue, Takako Chikenji, Miho Otani, Masako Nakano, Kazusa Oyama, Toshihiko Yamashita, Mineko Fujimiya

    Scientific Reports   10 ( 1 )   2020.12

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    Language：English   Publishing type：Research paper (scientific journal)   Publisher：Nature Research  

    DOI： 10.1038/s41598-020-78836-8

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  • An enriched environment prevents cognitive impairment in an Alzheimer’s disease model by enhancing the secretion of exosomal microRNA-146a from the choroid plexus Reviewed

    Masako Nakano, Kenta Kubota, Shin Hashizume, Eiji Kobayashi, Takako S. Chikenji, Yuki Saito, Mineko Fujimiya

    Brain, Behavior, & Immunity - Health   9   100149 - 100149   2020.10

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    Authorship：Lead author,　Corresponding author   Publishing type：Research paper (scientific journal)   Publisher：Elsevier BV  

    DOI： 10.1016/j.bbih.2020.100149

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  • Bone marrow-derived mesenchymal stem cells improve cognitive impairment in an Alzheimer's disease model by increasing the expression of microRNA-146a in hippocampus. Reviewed International journal

    Masako Nakano, Kenta Kubota, Eiji Kobayashi, Takako S Chikenji, Yuki Saito, Naoto Konari, Mineko Fujimiya

    Scientific reports   10 ( 1 )   10772 - 10772   2020.7

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    Authorship：Lead author,　Corresponding author   Language：English   Publishing type：Research paper (scientific journal)  

    Alzheimer's disease (AD) is characterized by the accumulation of amyloid-β and tau. We previously reported that administration of bone marrow mesenchymal stem cells (BM-MSCs) ameliorates diabetes-induced cognitive impairment by transferring exosomes derived from these cells into astrocytes. Here, we show that intracerebroventricularly injected BM-MSCs improve cognitive impairment in AD model mice by ameliorating astrocytic inflammation as well as synaptogenesis. Although AD model mice showed an increase in NF-κB in the hippocampus, BM-MSC-treated AD model mice did not show this increase but showed an increase in levels of microRNA (miR)-146a in the hippocampus. Intracerebroventricularly injected BM-MSCs were attached to the choroid plexus in the lateral ventricle, and thus, BM-MSCs may secrete exosomes into the cerebrospinal fluid. In vitro experiments showed that exosomal miR-146a secreted from BM-MSCs was taken up into astrocytes, and an increased level of miR-146a and a decreased level of NF-κB were observed in astrocytes. Astrocytes are key cells for the formation of synapses, and thus, restoration of astrocytic function may have led to synaptogenesis and correction of cognitive impairment. The present study indicates that exosomal transfer of miR-146a is involved in the correction of cognitive impairment in AD model mice.

    DOI： 10.1038/s41598-020-67460-1

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  • 間葉系間質/幹細胞が誘導する細胞老化-クリアランス-リモデリング連鎖は慢性腎不全の線維化を改善する

    千見寺 貴子, 齋藤 悠城, 中野 正子, 北 愛里紗, 藤宮 峯子

    日本腎臓学会誌   62 ( 4 )   260 - 260   2020.7

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    Language：Japanese   Publisher：(一社)日本腎臓学会  

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  • Exercise enhances skeletal muscle regeneration by promoting senescence in fibro-adipogenic progenitors Reviewed

    Yuki Saito, Takako S. Chikenji, Takashi Matsumura, Masako Nakano, Mineko Fujimiya

    Nature Communications   2020.2

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    Publishing type：Research paper (scientific journal)  

    DOI： 10.1038/s41467-020-14734-x

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  • p16INK4A-expressing mesenchymal stromal cells restore the senescence–clearance–regeneration sequence that is impaired in chronic muscle inflammation Reviewed

    Takako S. Chikenji, Yuki Saito, Naoto Konari, Masako Nakano, Yuka Mizue, Miho Otani, Mineko Fujimiya

    EBioMedicine   44   86 - 97   2019.6

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    Publishing type：Research paper (scientific journal)   Publisher：Elsevier {BV}  

    DOI： 10.1016/j.ebiom.2019.05.012

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  • Umbilical cord extracts improve osteoporotic abnormalities of bone marrow-derived mesenchymal stem cells and promote their therapeutic effects on ovariectomised rats Reviewed

    Akira Saito, Kanna Nagaishi, Kousuke Iba, Yuka Mizue, Takako Chikenji, Miho Otani, Masako Nakano, Kazusa Oyama, Toshihiko Yamashita, Mineko Fujimiya

    Scientific Reports   8 ( 1 )   1161   2018.12

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    Language：English   Publishing type：Research paper (scientific journal)   Publisher：Nature Publishing Group  

    DOI： 10.1038/s41598-018-19516-6

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  • Activated forms of astrocytes with higher GLT-1 expression are associated with cognitive normal subjects with Alzheimer pathology in human brain. Reviewed International journal

    Eiji Kobayashi, Masako Nakano, Kenta Kubota, Nobuaki Himuro, Shougo Mizoguchi, Takako Chikenji, Miho Otani, Yuka Mizue, Kanna Nagaishi, Mineko Fujimiya

    Scientific reports   8 ( 1 )   1712 - 1712   2018.1

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    Language：English   Publishing type：Research paper (scientific journal)  

    Although the cognitive impairment in Alzheimer's disease (AD) is believed to be caused by amyloid-β (Aβ) plaques and neurofibrillary tangles (NFTs), several postmortem studies have reported cognitive normal subjects with AD brain pathology. As the mechanism underlying these discrepancies has not been clarified, we focused the neuroprotective role of astrocytes. After examining 47 donated brains, we classified brains into 3 groups, no AD pathology with no dementia (N-N), AD pathology with no dementia (AD-N), and AD pathology with dementia (AD-D), which represented 41%, 21%, and 38% of brains, respectively. No differences were found in the accumulation of Aβ plaques or NFTs in the entorhinal cortex (EC) between AD-N and AD-D. Number of neurons and synaptic density were increased in AD-N compared to those in AD-D. The astrocytes in AD-N possessed longer or thicker processes, while those in AD-D possessed shorter or thinner processes in layer I/II of the EC. Astrocytes in all layers of the EC in AD-N showed enhanced GLT-1 expression in comparison to those in AD-D. Therefore these activated forms of astrocytes with increased GLT-1 expression may exert beneficial roles in preserving cognitive function, even in the presence of Aβ and NFTs.

    DOI： 10.1038/s41598-018-19442-7

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  • An enriched environment prevents diabetes-induced cognitive impairment in rats by enhancing exosomal miR-146a secretion from endogenous bone marrow-derived mesenchymal stem cells. Reviewed International journal

    Kenta Kubota, Masako Nakano, Eiji Kobayashi, Yuka Mizue, Takako Chikenji, Miho Otani, Kanna Nagaishi, Mineko Fujimiya

    PloS one   13 ( 9 )   e0204252   2018

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    Language：English  

    Increasing evidence suggests that an enriched environment (EE) ameliorates cognitive impairment by promoting repair of brain damage. However, the mechanisms by which this occurs have not been determined. To address this issue, we investigated whether an EE enhanced the capability of endogenous bone marrow-derived mesenchymal stem/stromal cells (BM-MSCs) to prevent hippocampal damage due to diabetes by focusing on miRNA carried in BM-MSC-derived exosomes. In diabetic streptozotocin (STZ) rats housed in an EE (STZ/EE), cognitive impairment was significantly reduced, and both neuronal and astroglial damage in the hippocampus was alleviated compared with STZ rats housed in conventional cages (STZ/CC). BM-MSCs isolated from STZ/CC rats had functional and morphological abnormalities that were not detected in STZ/EE BM-MSCs. The miR-146a levels in exosomes in conditioned medium of cultured BM-MSCs and serum from STZ/CC rats were decreased compared with non-diabetic rats, and the level was restored in STZ/EE rats. Thus, the data suggest that increased levels of miR-146a in sera were derived from endogenous BM-MSCs in STZ/EE rats. To examine the possibility that increased miR-146a in serum may exert anti-inflammatory effects on astrocytes in diabetic rats, astrocytes transfected with miR-146a were stimulated with advanced glycation end products (AGEs) to mimic diabetic conditions. The expression of IRAK1, NF-κB, and tumor necrosis factor-α was significantly higher in AGE-stimulated astrocytes, and these factors were decreased in miR-146a-transfected astrocytes. These results suggested that EEs stimulate up-regulation of exosomal miR-146a secretion by endogenous BM-MSCs, which exerts anti-inflammatory effects on damaged astrocytes and prevents diabetes-induced cognitive impairment.

    DOI： 10.1371/journal.pone.0204252

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  • Umbilical cord extracts improve diabetic abnormalities in bone marrow-derived mesenchymal stem cells and increase their therapeutic effects on diabetic nephropathy Reviewed

    Kanna Nagaishi, Yuka Mizue, Takako Chikenji, Miho Otani, Masako Nakano, Yusaku Saijo, Hikaru Tsuchida, Shinichi Ishioka, Akira Nishikawa, Tsuyoshi Saito, Mineko Fujimiya

    SCIENTIFIC REPORTS   7 ( 1 )   8484   2017.8

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    Language：English   Publishing type：Research paper (scientific journal)  

    DOI： 10.1038/s41598-017-08921-y

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  • Mesenchymal stem cell therapy ameliorates diabetic nephropathy via the paracrine effect of renal trophic factors including exosomes Reviewed

    Kanna Nagaishi, Yuka Mizue, Takako Chikenji, Miho Otani, Masako Nakano, Naoto Konari, Mineko Fujimiya

    SCIENTIFIC REPORTS   6   34842   2016.10

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    Language：English   Publishing type：Research paper (scientific journal)  

    DOI： 10.1038/srep34842

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  • 胎児付属物抽出液で賦活化した骨髄間葉系幹細胞による糖尿病性腎症の新規治療法の開発

    永石 歓和, 水江 由佳, 千見寺 貴子, 中野 正子, 小成 直人, 藤宮 峯子, 大谷 美穂

    北海道外科雑誌   61 ( 1 )   126 - 127   2016.6

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    Language：Japanese   Publisher：北海道外科学会  

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  • Bone marrow-derived mesenchymal stem cells improve diabetes-induced cognitive impairment by exosome transfer into damaged neurons and astrocytes Reviewed

    Masako Nakano, Kanna Nagaishi, Naoto Konari, Yuki Saito, Takako Chikenji, Yuka Mizue, Mineko Fujimiya

    Scientific Reports   6 ( 1 )   24805   2016.4

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    Authorship：Lead author   Publishing type：Research paper (scientific journal)   Publisher：Springer Science and Business Media {LLC}  

    DOI： 10.1038/srep24805

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  • Hydrogen Improves Glycemic Control in Type1 Diabetic Animal Model by Promoting Glucose Uptake into Skeletal Muscle Reviewed

    Haruka Amitani, Akihiro Asakawa, Kaichun Cheng, Marie Amitani, Kaori Kaimoto, Masako Nakano, Miharu Ushikai, Yingxiao Li, Minglun Tsai, Jiang-Bo Li, Mutsumi Terashi, Huhe Chaolu, Ryozo Kamimura, Akio Inui

    PLOS ONE   8 ( 1 )   e53913   2013.1

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    Language：English   Publishing type：Research paper (scientific journal)  

    DOI： 10.1371/journal.pone.0053913

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  • Metformin and incretin-based therapies up-regulate central and peripheral Adenosine monophosphate-activated protein affecting appetite and metabolism. Reviewed

    Nakano M, Inui A

    Indian journal of endocrinology and metabolism   16 ( Suppl 3 )   S529 - 31   2012.12

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  • Long-term correction of type 1 and 2 diabetes by central leptin gene therapy independent of effects on appetite and energy expenditure. Reviewed

    Nakano M, Asakawa A, Inui A

    Indian journal of endocrinology and metabolism   16 ( Suppl 3 )   S556 - 61   2012.12

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  • Liquorrhea with multiple subdural hematomas causing reversible prospagnosia Reviewed

    Masako Nakano, Fujio Umehara

    Clinical Neurology   52 ( 2 )   96 - 101   2012.2

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    Language：Japanese   Publishing type：Research paper (scientific journal)   Publisher：2  

    DOI： 10.5692/clinicalneurol.52.96

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MISC

  • 献体脳におけるアルツハイマー病理と認知機能に関する研究

    中野 正子, 小林 英司, 永石 歓和, 久原 真, 藤宮 峯子

    臨床神経学   64 ( 6 )   431 - 431   2024.6

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    Language：Japanese   Publisher：(一社)日本神経学会  

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  • 三次元培養した骨髄間葉系幹細胞のアルツハイマー型認知症モデルマウスへの効果

    中野正子, 橋爪紳, 木原花野, 藤宮峯子, 藤宮峯子

    日本再生医療学会総会(Web)   23rd   2024

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  • アルツハイマー病理陽性で認知機能が正常であった症例における脈絡叢の解析

    中野正子, 小林英司, 小林英司, 橋爪紳, 藤宮峯子

    日本解剖学会総会・全国学術集会講演プログラム・抄録集   127th   2022

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  • 骨髄間葉系幹細胞はmiR-146aを内包するエクソソームを分泌しアルツハイマー病マウスの認知障害を改善させる

    中野正子, 久保田健太, 小林英司, 千見寺貴子, 齋藤悠城, 小成直人, 藤宮峯子

    日本再生医療学会総会(Web)   19th   2020

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  • アルツハイマー病理陽性で非認知症であった症例における反応性アストロサイトの解析

    小林 英司, 中野 正子, 久保田 健太, 樋室 伸顕, 溝口 照悟, 千見寺 貴子, 大谷 美穂, 水江 由佳, 永石 歓和, 藤宮 峯子

    Dementia Japan   31 ( 4 )   578 - 578   2017.10

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    Language：Japanese   Publisher：(一社)日本認知症学会  

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  • 刺激豊かな環境での飼育がアルツハイマー病モデルマウスに与える影響の解析

    中野 正子, 小林 英司, 久保田 健太, 大谷 美穂, 千見寺 貴子, 水江 由佳, 永石 歓和, 藤宮 峯子

    Dementia Japan   31 ( 4 )   573 - 573   2017.10

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  • 刺激豊かな環境での飼育がアルツハイマー病モデルマウスに与える影響の解析

    中野 正子, 小林 英司, 久保田 健太, 大谷 美穂, 千見寺 貴子, 水江 由佳, 永石 歓和, 藤宮 峯子

    Dementia Japan   31 ( 4 )   573 - 573   2017.10

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    Language：Japanese   Publisher：(一社)日本認知症学会  

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  • 骨髄間葉系幹細胞はエクソソームを分泌し糖尿病性認知症を改善させる

    中野 正子, 小成 直人, 齋藤 悠城, 千見寺 貴子, 水江 由佳, 永石 歓和, 藤宮 峯子, 大谷 美穂

    北海道外科雑誌   61 ( 1 )   126 - 126   2016.6

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    Language：Japanese   Publisher：北海道外科学会  

    Ichushi

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  • 骨髄間葉系幹細胞はエクソソームを分泌し糖尿病性認知症を改善させる

    中野 正子, 小成 直人, 齋藤 悠城, 千見寺 貴子, 水江 由佳, 永石 歓和, 藤宮 峯子

    糖尿病   59 ( Suppl.1 )   S - 295   2016.4

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    Language：Japanese   Publisher：(一社)日本糖尿病学会  

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  • 骨髄間葉系幹細胞はエクソソームを分泌し糖尿病関連学習記憶障害を改善させる

    中野正子, 小成直人, 齋藤悠城, 千見寺貴子, 水江由佳, 永石歓和, 藤宮峯子

    再生医療   15   291   2016.2

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  • 骨髄間葉系幹細胞はエクソソームを分泌し糖尿病性認知症を改善させる

    中野正子, 小成直人, 齋藤悠城, 千見寺貴子, 水江由佳, 永石歓和, 藤宮峯子

    糖尿病(Web)   59 ( Suppl )   2016

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  • 興味ある経過をたどった神経性食欲不振症の一例

    中野正子, 野添新一

    心身医学   54 ( 2 )   178 - 178   2014.2

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    Language：Japanese   Publisher：(一社)日本心身医学会  

    DOI： 10.15064/jjpm.54.2_178_1

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  • 重度睡眠時無呼吸症候群を認める若年の高度肥満に対し,減量プログラムが効果的であったと考えられる1例

    中野正子, 小山憲一郎, 向井美希, 春田いづみ, 網谷東方, 浅川明弘, 乾明夫

    日本肥満症治療学会学術集会プログラム・抄録集   30th   95 - 95   2012.6

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    Language：Japanese   Publisher：日本肥満症治療学会  

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  • ニューロペプチド―update 食欲制御 ニューロペプチドY(レプチン系)と食欲制御

    中野正子, 浅川明弘, 乾明夫

    Clin Neurosci   30 ( 2 )   158 - 162   2012.2

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    Language：Japanese   Publisher：(株)中外医学社  

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  • Liquorrhea with multiple subdural hematomas causing reversible prospagnosia

    NAKANO MASAKO, UMEHARA FUJIO

    臨床神経学   52 ( 2 )   96 - 101   2012.2

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    Language：Japanese   Publisher：(一社)日本神経学会  

    DOI： 10.5692/clinicalneurol.52.96

    Ichushi

    J-GLOBAL

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  • Asterixisを呈した高マグネシウム血症の6例:見逃されている酸化マグネシウム過量投与

    梅原藤雄, 中野正子

    日本神経学会学術大会プログラム・抄録集   53rd   2012

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  • 消化器疾患の知覚受容機構の研究の進歩 IBSに知覚異常は関与しているか

    中野正子, 乾明夫

    分子消化器病   8 ( 4 )   345 - 351   2011.12

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    Language：Japanese   Publisher：(株)先端医学社  

    Ichushi

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  • Asterixisを呈した高マグネシウム血症の3例

    中野正子, 伊集院俊郎, 梅原藤雄, 内田義男

    臨床神経学   51 ( 9 )   726 - 726   2011.9

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    Ichushi

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  • 経過中,相貌失認を生じた脳脊髄液減少症の1例

    中野正子, 梅原藤雄

    臨床神経学   51 ( 8 )   638 - 638   2011.8

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    Ichushi

    J-GLOBAL

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  • <sup>18</sup>F‐FDG‐PETが診断に有用であったNeurolymphomatosisの一例

    中野正子, 日高亮, 梅原藤雄, 神崎史子, 池ノ上彩, 加治屋より子, 大塚真紀

    臨床神経学   51 ( 7 )   544   2011.7

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  • 18F-FDG-PETが診断に有用であったNeurolymphomatosisの一例

    中野 正子, 日高 亮, 梅原 藤雄, 神崎 史子, 池ノ上 彩, 加治屋 より子, 大塚 真紀

    臨床神経学   51 ( 7 )   544 - 544   2011.7

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    Ichushi

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  • 18F-FDG PETが診断に有用であった神経リンパ腫症の1例

    中野 正子, 日高 亮, 神崎 史子, 加治屋 より子, 梅原 藤雄

    神経内科   75 ( 1 )   88 - 92   2011.7

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Research Projects

  • 認知機能に有効なmiRNAを内包する間葉系幹細胞由来エクソソームの開発―多孔質担体を用いた検討―

    2024.4 - 2025.3

    日立財団  倉田奨励金 

    中野 正子

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    Authorship：Principal investigator 

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  • アルツハイマー病理に抗する認知症予防法と機序解明―献体脳を用いた前向き研究

    Grant number：22K07402  2022.4 - 2025.3

    日本学術振興会  科学研究費助成事業  基盤研究(C)

    中野 正子, 小林 英司, 橋爪 紳, 久保田 健太, 藤宮 峯子

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    Grant amount：\4290000 （ Direct Cost: \3300000 、 Indirect Cost：\990000 ）

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  • 献体脳のアルツハイマー病理から考える認知症治療の開発研究

    2021.9 - 2022.3

    ノーステック財団  若手研究人材・ネットワーク育成補助金 

    中野 正子

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  • 死後脳のアルツハイマー病理と生前認知機能から考える認知症発症抑制メカニズムの解明

    2020.7 - 2021.3

    秋山記念生命科学振興財団  研究助成＜奨励＞ 

    中野 正子

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  • マインドフルネスによる認知症発症抑制と血中microRNAの変化についての検討

    2019.4 - 2022.3

    日本学術振興会  科研費 若手研究 

    中野 正子

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    Authorship：Principal investigator  Grant type：Competitive

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  • 豊かな環境による認知症抑制機序の解明～ヒト・マウスのアストロサイトに着目した検討

    2016.4 - 2019.3

    日本学術振興会  科研費 若手B 

    中野 正子

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    Authorship：Principal investigator  Grant type：Competitive

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  • 骨髄間葉系幹細胞による認知症への効果の検討の解析

    2015.9 - 2016.3

    ノーステック財団  若手研究人材・ネットワーク育成補助金 

    中野 正子

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    Authorship：Principal investigator  Grant type：Competitive

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