Authorship：Corresponding author   Publishing type：Research paper (scientific journal)   Publisher：SAGE Publications  

Objective

This study aimed to compare the reliability of the Timed Up and Go Test (TUG) and 1-Minute Walk Test (1MWT) in children with cerebral palsy (CP); tests were administered by clinically experienced physiotherapists and physiotherapy students.

Methods

In this mixed-methods study, 30 ambulatory children (mean age: 13 years) with CP were administered TUG and 1MWT by five licensed physiotherapists and 18 physiotherapy students.

Results

The intraclass correlation coefficient for inter-rater reliability between the physiotherapists and students was 0.99 (95% confidence interval [CI]: 0.98–0.99) for TUG and 0.92 (95% CI: 0.83–0.96) for 1MWT. Α Bland–Altman analysis identified a fixed bias in the negative and positive directions for TUG and 1MWT, respectively. Statistical analysis revealed a proportional bias in TUG. A qualitative analysis showed that while physiotherapists followed the instruction manual and provided clear instructions, the students did not follow the manual and were tense, triggering a negative response from the children.

Conclusions

The difference in clinical experience of professionals administering the TUG and 1MWT to children with CP impacted measurement outcomes. In contrast to physiotherapy students, more experienced physiotherapists ensured that the child was not anxious, provided clear instructions, and performed measurements as per the manual.

Other Link： https://journals.sagepub.com/doi/full-xml/10.1177/22130683251337328

DOI： 10.1177/22130683251337328

researchmap

Authorship：Last author   Publishing type：Research paper (scientific journal)   Publisher：Ovid Technologies (Wolters Kluwer Health)  

ABSTRACT

Introduction

Although knee-ankle-foot orthosis (KAFO) therapy is considered effective for improving functional mobility in patients with stroke, the certainty of the evidence remains unclear.

Objective

The aim of this study was to determine the certainty of evidence of treatment effect of KAFO therapy, the methodological quality, and the current status of KAFO therapy in patients with stroke based on existing research.

Methods

Data from studies that examined the treatment effect of KAFO on functional mobility or activities of daily living in patients with stroke were searched on seven databases: PubMed, CINAHL, Scopus, CENTRAL, PEDro, WoS, and Igaku Chuo Zassi. The results were reported according to the Preferred Reporting Items for Systematic Review and Meta-Analyses (PRISMA) statement. The overall status of KAFO therapy was summarized descriptively. The certainty of the evidence was assessed using the Grading of Recommendations, Assessment, Development, and Evaluation (GRADE) approach. Methodological quality was assessed using the STROBE statement.

Results

Three observational studies were included in the analysis, but no random controlled trials (RCTs) were identified. The certainty of the evidence for treatment effect of KAFO therapy in stroke was very low. The included studies did not adequately control potential confounders. The treatment effects of KAFO therapy for different levels of lower-limb paralysis and those on walking ability outcomes remain unclear.

Conclusions

The lack of RCTs limits the evidence for the treatment effect of KAFO therapy in patients with stroke. This systematic review of observational studies highlights the low certainty of current evidence and identifies key areas for improvement in future research.

Clinical Relevance

This is the first systematic review of observational studies to elucidate current evidence of the treatment effect of KAFOs in patients with stroke. KAFOs may improve functional mobility and activities of daily living; however, the certainty of the evidence is very low, and high-quality trials are needed to establish the benefits of KAFO therapy for these patients.

DOI： 10.1097/jpo.0000000000000552

researchmap

Language：English   Publishing type：Research paper (scientific journal)  

This study investigated the relationship between psychological traits and chronic pain using the Structured Association Technique (SAT) method to evaluate psychological factors associated with chronic pain. The participants included 105 older adults (23 men, 82 women, mean age 80.82 years) who received rehabilitation services. Chronic pain severity was assessed using a numerical rating scale (NRS), and psychological traits were evaluated by SAT. In addition, maternal attachment experiences in childhood were examined. The NRS showed significant positive correlations with the self-suppressing behavioral pattern (S) scale (r =  0.31, p =  0.001), and the depression (D) scale (r =  0.31, p =  0.001). The proportion of participants with high scores on both the S and D scales (SD group) was notably higher in the high NRS group. Logistic regression analysis showed that the SD group had a higher odds ratio (OR =  8.469, p =  0.004) for severe chronic pain, suggesting that SD traits independently contribute to worse pain. In the SD group, the self-denial scale scores were high, and self-denial traits showed a negative correlation with maternal attachment experiences in childhood. This finding indicates that poor maternal attachment may enhance self-denial traits, which in turn indirectly worsen pain through their effects on S and D traits. The results of this study highlight the importance of S and D traits as psychological factors in chronic pain, particularly in Japanese populations, and suggest that assessing self-suppressing behavioral patterns may be beneficial for pain management. However, the cross-cultural validity of the SAT scales requires further investigation. SAT therapy may provide a comprehensive approach to the treatment and prevention of complex conditions influenced by psychological and social factors, including chronic pain.

DOI： 10.1371/journal.pone.0319647

PubMed

researchmap

Language：English   Publishing type：Research paper (scientific journal)  

BACKGROUND: Hypertensive disorders of pregnancy (HDP) significantly increase the risk of developing hypertension and cardiovascular disease (CVD) later in life and are a major cause of maternal mortality. However, little is known about the nationwide, long-term, all-inclusive status of HDP. OBJECTIVE: To estimate the incidence of HDP from 2011 to 2019 in Hokkaido, Japan, with a focus on age groups. METHODS: Using National Database (NDB) insurance medical data, a retrospective analysis was conducted. Due to the absence of direct pregnancy data, birth numbers were used as a surrogate for the number of pregnant women to calculate the incidence of HDP. RESULTS: The average incidence rate of HDP over 9 years was 6.37%. The incidence rate was lowest among women aged 25-29 years, at 5.58% (95% confidence interval [CI]: 5.43-5.73), and increased with age, peaking at 10.58% (95% CI: 10.10-11.09) among women over 40 years. Notably, the incidence rate for women under 20 years of age was 6.70% (95% CI: 5.97-7.51), which was higher than that for women in their 20s. A mean annual increase of 0.25% in age-adjusted incidence was observed during this period, which was statistically significant (R² =  0.87, p <  0.01). CONCLUSION: This study reveals that the risk of developing HDP is associated with both older childbearing and younger pregnancies and follows a J-curve, suggesting that factors other than maternal aging also contribute to the increased incidence of HDP and that further research on risk factors for HDP, which is on the rise worldwide, is urgently needed.

DOI： 10.1371/journal.pone.0319177

PubMed

researchmap

Language：English   Publishing type：Research paper (scientific journal)  

RATIONALE: To date, family satisfaction with emergency medical technicians (EMTs) has only been reported through narrative statements in subjective evaluations. Although a quantitative assessment of healthcare professional satisfaction is desirable, no specific measures have been devised to assess family satisfaction with the healthcare and care provided by EMTs. AIMS AND OBJECTIVES: This study aimed to develop and validate an EMT care family satisfaction scale to measure patient satisfaction with prehospital emergency care. METHODS: The study population comprised 216 family members (N = 216) of patients who used ambulances between November 2020 and May 2021 in a single region in Japan. Questionnaires were distributed to the participants who provided informed consent. An exploratory factor analysis of construct validity was performed to validate the Family Satisfaction Scale. The Cronbach's alpha was used to validate the internal consistency reliability of the scale. RESULTS: The exploratory factor analysis results revealed a four-factor structure: 'explanation and communication,' 'physical treatment,' 'psychological support,' and 'environment in the ambulance.' The Cronbach's range (0.80-0.93) for the total score for each of these four factors and the overall total score confirmed favorable internal reliability of this study. CONCLUSIONS: The family satisfaction scale developed in this study was constructed and validated to highlight the role of EMTs and needs of the families in the prehospital care settings. Moreover, this scale can be applied in the evaluation and consideration of interventions to improve family satisfaction with EMTs.

DOI： 10.1111/jep.14090

PubMed

researchmap

Authorship：Corresponding author   Language：English   Publishing type：Research paper (scientific journal)  

PURPOSE: The aim of this study was to develop the Japanese version of the ABILHAND-Kids and to examine its psychometric properties for Japanese children with cerebral palsy (CP). METHODS: The experimental version of 75 items was developed using forward-backward translation method. Parents of 137 children with CP answered it. Their responses were analyzed to successive items, and psychometric properties of the final version were investigated through the Rasch measurement model. RESULTS: The Japanese version of the ABILHAND-Kids contained 22 items. It showed valid item-patient targeting, no significant floor and ceiling effects, and no differential item functioning for demographic and clinical subgroups. All items contributed to the definition of one-dimensional measure. For internal consistency, the person separation index was 0.94. For test-retest reliability, the intraclass correlation coefficients were 0.96 (95% CI: 0.92-0.98). The minimal detectable difference was calculated with a logit score of 0.79 and a total raw score of 4.50. The logit score showed a strong correlation with the Manual Ability Classification System level (ρ= -0.70) and the Gross Motor Function Classification System level (ρ= -0.62). CONCLUSIONS: The Japanese version of the ABILHAND-Kids was found to be valid and reliable. It appears to be a good tool for assessing manual abilities in daily activities in children with CP.

DOI： 10.1080/09638288.2024.2338201

PubMed

researchmap

Language：English   Publishing type：Research paper (scientific journal)  

Sarcopenia is the core factor of frailty. This study specifically focused on lower limb muscle strength and examined muscle indices that indicate the risk of frailty or pre-frailty in older adults. The study included 327 community-dwelling individuals aged ≥65 years (43.7% male) who participated in the cohort. Frailty was defined based on five symptoms: weight loss, low activity level, exhaustion, weakness and slowness. Participants were classified into frail (three or more applicable), pre-frail (one to two applicable) and non-frail groups. Muscle strength (knee extension strength, toe grip strength and hand grip strength) were assessed, and appendicular muscle mass was assessed via a bioelectrical impedance analysis. The adjusted odds ratio (OR) of muscle indices for with frailty (frail group vs. pre-frail group) or pre-frailty (pre-frail group vs. non-frail group) were calculated. The prevalence of frail and pre-frail was 7% and 40%, respectively. Adjusted for age, sex, albumin and medical history, knee extension strength was significantly associated with frailty (odds ratio 0.95, 95% CI 0.92-0.98), while hand grip strength was associated with pre-frailty (odds ratio 0.92, 95% CI 0.88-0.97) but not with other muscle indices. This study is significant for identifying knee extension strength as a factor relevant to frailty in older adults considered pre-frailty, emphasizing the importance of this specific muscle measure in predicting and managing frailty.

DOI： 10.3390/geriatrics9010009

PubMed

researchmap

Authorship：Last author,　Corresponding author   Language：English   Publishing type：Research paper (scientific journal)  

BACKGROUND: Children with cerebral palsy (CP) often experience visual dysfunction that affects motor function and activities of daily living, but no 'gold standard' classification of visual function has been established. In recent years, however, a valid and reliable Visual Function Classification System (VFCS) for children with CP has been developed. AIMS: To examine the reliability and validity of the Japanese version of the VFCS in individuals with CP. METHODS: The translation of the VFCS was performed according to international standards for the translation of measurements. We conducted questionnaires of professionals (three physicians, eight physical therapists, five occupational therapists, six speech-language-hearing therapists and a certified orthoptist) regarding the content validity of the Japanese version of the VFCS. For reliability and concurrent validity, 148 individuals with CP were classified twice by professionals using the Japanese version of the VFCS, Gross Motor Function Classification System (GMFCS), Manual Ability Classification System (MACS), Communication Function Classification System (CFCS) and Eating and Drinking Ability Classification System (EDACS), with several weeks between each evaluation. RESULTS: The content validity of the Japanese version of the VFCS almost met the criteria set. The percentage of positive and neutral opinions given by the professionals with regard to the four items ranged from 74% to 92%. The intra-rater reliability was 0.86 (95% CI 0.75-0.96) by Cohen's kappa and 0.93 (95% CI 0.88-0.96) by intraclass correlation coefficient. The inter-rater reliability was 0.67 (95% CI 0.56-0.78) by Cohen's kappa and 0.79 (95% CI 0.69-0.86) by intraclass correlation coefficient. The Spearman correlation coefficients between the VFCS and the GMFCS, MACS, CFCS and EDACS were 0.783, 0.764, 0.738, 0.738 and 0.830, respectively. The concurrent validity was confirmed by the correlations observed with other classification systems. CONCLUSIONS: The results indicated good reliability and validity for the Japanese version of the VFCS.

DOI： 10.1111/cch.13175

PubMed

researchmap

Language：Japanese   Publisher：Japanese Society of Pediatric Physical Therapy  

Other Link： https://search.jamas.or.jp/default/link?pub_year=2023&ichushi_jid=J07741&link_issn=&doc_id=20230428360001&doc_link_id=10.60187%2Fjjppt.1.1_7&url=https%3A%2F%2Fdoi.org%2F10.60187%2Fjjppt.1.1_7&type=J-STAGE&icon=https%3A%2F%2Fjk04.jamas.or.jp%2Ficon%2F00007_3.gif

DOI： 10.60187/jjppt.1.1_7

CiNii Research

Ichushi

researchmap

Language：English   Publishing type：Research paper (scientific journal)  

BACKGROUND: Prehospital delay in reaching a percutaneous coronary intervention (PCI) facility is a major problem preventing early coronary reperfusion in patients with ST-elevation myocardial infarction (STEMI). The aim of this study was to identify modifiable factors that contribute to the interval from symptom onset to arrival at a PCI-capable center with a focus on geographical infrastructure-dependent and -independent factors. METHODS: We analyzed data from 603 STEMI patients who received primary PCI within 12 h of symptom onset in the Hokkaido Acute Coronary Care Survey. We defined onset-to-door time (ODT) as the interval from the onset of symptoms to arrival at the PCI facility and we defined door-to-balloon time (DBT) as the interval from arrival at the PCI facility to PCI. We analyzed the characteristics and factors of each time interval by type of transportation to PCI facilities. In addition, we used geographical information system software to calculate the minimum prehospital system time (min-PST), which represents the time required to reach a PCI facility based on geographical factors. We then subtracted min-PST from ODT to find the estimated delay-in-arrival-to-door (eDAD), which represents the time required to reach a PCI facility independent of geographical factors. We investigated the factors related to the prolongation of eDAD. RESULTS: DBT (median [IQR]: 63 [44, 90] min) was shorter than ODT (median [IQR]: 104 [56, 204] min) regardless of the type of transportation. However, ODT was more than 120 min in 44% of the patients. The min-PST (median [IQR]: 3.7 [2.2, 12.0] min) varied widely among patients, with a maximum of 156 min. Prolongation of eDAD (median [IQR]: 89.1 [49, 180] min) was associated with older age, absence of a witness, onset at night, no emergency medical services (EMS) call, and transfer via a non-PCI facility. If eDAD was zero, ODT was projected to be less than 120 min in more than 90% of the patients. CONCLUSIONS: The contribution of geographical infrastructure-dependent time in prehospital delay was substantially smaller than that of geographical infrastructure-independent time. Intervention to shorten eDAD by focusing on factors such as older age, absence of a witness, onset at night, no EMS call, and transfer via a non-PCI facility appears to be an important strategy for reducing ODT in STEMI patients. Additionally, eDAD may be useful for evaluating the quality of STEMI patient transport in areas with different geographical conditions.

DOI： 10.1186/s12942-023-00328-5

PubMed

researchmap

Language：English   Publishing type：Research paper (scientific journal)  

The purpose of this study was to develop and validate an emergency medical technician (EMT) care patient satisfaction scale to measure patient satisfaction with prehospital emergency care. To date, patient satisfaction surveys of EMTs have been performed subjectively, e using each facility's questionnaire, without the use of a validated patient satisfaction scale. However, no specific scale has been devised to assess patient satisfaction with EMTs. The study population comprised patients who used an ambulance between November 2020 and May 2021 (N = 202). A survey instrument was administered to participants who provided informed consent. In the process of validating the patient satisfaction scale, an exploratory factor analysis (EFA) of construct validity was performed. The results of the EFA showed a factor structure consisting of five factors: "teamwork", "explanation and communication", "physical treatment and psychological support", "quickness of transport", and "environment in the ambulance". In addition, domain and summary scores showed good internal reliability (Cronbach's range = 0.82-0.94). The patient satisfaction scale developed in this study was designed and validated considering the role of EMTs and patients' needs for prehospital care. This scale may be useful in the development of assessments and interventions to improve patient satisfaction with EMTs.

DOI： 10.3934/publichealth.2023011

PubMed

researchmap

Language：English   Publishing type：Research paper (scientific journal)  

OBJECTIVE: To investigate roles of sarcopenia indexes in prediction of development of insulin resistance in nondiabetic older adults. DESIGN: A 2-year follow-up cohort. SETTING AND PARTICIPANTS: The Tanno-Sobetsu study, a prospective observational cohort, included 194 community-dwelling nondiabetic older adults during 2017-2019. METHODS: Lower limb, upper limb, appendicular, and trunk muscle masses by a bioelectrical impedance analysis, grip strength, knee extension torque, and walking speed were measured in study participants aged ≥65 years (79 men and 115 women) at baseline. Muscle mass and strength were divided by the weight, and then multiplied by 100 to calculate the weight ratio (%). Insulin resistance was assessed by homeostasis model (HOMA-IR) at baseline, and the study participants whose HOMA-IR was less than 1.73 at baseline were followed for a maximum of 2 years. The study endpoint was development of insulin resistance defined as HOMA-IR ≥1.73. The adjusted hazard ratio (HR) of each sarcopenia component for development of insulin resistance was calculated. RESULTS: Lower limb muscle mass (HR 0.88, 95% CI 0.79-0.98) and appendicular muscle mass (HR 0.89, 95% CI 0.81-0.99), but not other sarcopenia components, were associated with the development of insulin resistance, independently of sex and age, HOMA-IR, and waist circumference at baseline. CONCLUSIONS AND IMPLICATIONS: The loss of lower limb muscle mass is a significant risk factor for development of insulin resistance independently of obesity in nondiabetic older adults. The lower limb muscle mass may be a novel target of interventions for the prevention of diabetes in older adults.

DOI： 10.1016/j.jamda.2022.12.002

PubMed

researchmap

Language：English   Publishing type：Research paper (scientific journal)  

The decline in physical function with age is a major contributor to the need for long-term care. Age-related changes in hand grip strength, knee extension, and walking speed have been reported in cross-sectional studies, but longitudinal data are needed. This longitudinal study measured changes in these three measures among community-dwelling adults aged 65-89 years who participated in general health examinations between 2017 and 2019. Analyses were stratified by sex. Linear mixed-effects models adjusted for confounding factors were used to examine the interaction of different patterns of change with age of the three measures. A total of 284 participants were included in the analysis. The interaction term of age × walking speed, with age × handgrip strength as the reference, was statistically significant in women and showed different patterns in walking speed and hand grip strength. In men, none of the age × physical function interaction terms were significant in any model. For early recognition of the onset of physical function decline in older adults, any of the three measures may be used in men, but walking speed may be more suitable than hand grip strength in women. These findings may be useful in devising sex-specific screening strategies.

DOI： 10.3390/ijerph192315769

PubMed

researchmap

Authorship：Last author,　Corresponding author   Language：English   Publishing type：Research paper (scientific journal)  

PURPOSE: The study sought to examine the content validity, the intra- and inter-rater reliability, and concurrent validity of the Japanese versions of the Manual Ability Classification System, the Communication Function Classification System, and the Eating and Drinking Ability Classification System, and representation of the distribution of the levels of each classification systems in comparison to the Gross Motor Function Classification System levels for children with cerebral palsy. METHODS: The Japanese versions were developed using the back-translation method. For content validity, professionals were asked to complete a questionnaire including items on the appropriateness of the translation, its validity, and distinctions among levels. For reliability, professionals used the three classification systems twice in children with cerebral palsy. For concurrent validity, relationships among the four classification systems were examined by correlation analyses. RESULTS: Participants included twenty-one professionals and 290 children with cerebral palsy (mean age: 12 years two months, female: 132, male: 158). The content validity was generally good. For reliability, the lower limit of the 95% confidence interval for the intraclass correlation coefficients was greater than 0.89, and the correlation coefficients were high. CONCLUSION: The results of this study showed good reliability and validity of the functional classification systems in Japan.

DOI： 10.3233/PRM-210098

PubMed

researchmap

Authorship：Last author   Language：English   Publishing type：Research paper (scientific journal)  

OBJECTIVE:  To synthesize available evidence from case reports regarding the efficacy of knee-ankle-foot orthosis (KAFO) on functional mobility and activities of daily living (ADL) in patients with stroke. METHODS:  The following databases were searched, based on the Population Intervention Comparison Outcome (PICO) model: PubMed, CINAHL, Sco- pus, Cochrane Central Register of Controlled Trials, PEDro, Web of Science, and Igaku Chuo Zassi (in Japanese). Methodological quality was assessed using the CARE checklist. RESULTS:  A total of 14 articles, including 15 cases, were selected. Clinically meaningful improvement in functional mobility was reported in 10 of 15 cases, measured using the Functional Ambulatory Category, Trunk Control Test, walking speed, and Berg Balance Scale. Clinically meaningful improvement in ADL was reported in 9 of 15 cases, measured using the Barthel Index and Functional Independent Measure. However, the methodological quality of the reviewed articles was low, with missing information on limitations of management, adverse events, and patient-reported outcomes. CONCLUSION:  This systematic review of case reports found a low level of evidence of the efficacy of KAFO in terms of improvement in functional mobility and ADL. Of value, this study revealed the optimal outcomes for measuring the efficacy of KAFO.

DOI： 10.2340/jrm.v54.87

PubMed

researchmap

Authorship：Last author   Language：English   Publishing type：Research paper (scientific journal)  

BACKGROUND: The Edinburgh Visual Gait Score (EVGS) has been used for observational gait assessment in children with cerebral palsy (CP). However, the measurement error of the EVGS and its detailed relationship with gross motor function remain unclear. RESEARCH QUESTIONS: This study aimed to confirm the intra-rater and inter-rater reliability as well as the minimal detectable change (MDC) values for the EVGS with the use of the video analysis software and examine the relationship between the EVGS and the Gross Motor Function Measure 66 (GMFM-66) with regard to construct validity. METHODS: This cross-sectional study was conducted for 62 children (mean age 11.3 ± 3.9 years) with spastic CP at Gross Motor Function Classification System (GMFCS) level I (32 children), II (25 children) or III (5 children). Three raters independently scored the EVGS using Kinovea video analysis software. The intra-rater and inter-rater reliability were calculated using intra-class correlation coefficients (ICC2,1), and the MDC90 was calculated using standard error of measurement. The construct validity was examined by correlating the EVGS with the GMFM-66. RESULTS: The EVGS showed good or excellent reliability within each rater (ICC2,1 = 0.90-0.97) and between raters (ICC2,1 = 0.91). The MDC90 of the EVGS ranged from 3.6 to 6.0. There was a significant correlation between the EVGS and the GMFM-66 (r = - 0.69 to - 0.73, p < 0.001). SIGNIFICANCE: The intra-rater and inter-rater reliability of the EVGS is sufficient for observational gait assessment. The high correlation between the EVGS and the GMFM-66 supports its construct validity. The authors propose an MDC of 6.0 for the EVGS. These results can help in the application of EVGS to children with CP at GMFCS level I-II with mild to moderate gait pathology, as there were few children with CP at GMFCS level III.

DOI： 10.1016/j.gaitpost.2022.03.004

PubMed

researchmap

Language：English   Publishing type：Research paper (scientific journal)  

OBJECTIVE: The aim of this study was to examine the feasibility and informativeness of the Canadian Occupational Performance Measure (COPM) for identifying the priorities of patients with Parkinson's disease (PD). METHODS: The COPM was administered in patients with PD who were admitted to the hospital. Feasibility was investigated by confirming the acceptability and practicality of the COPM interview. To investigate informativeness, identified priorities were classified according to the International Classification of Functioning, Disability and Health (ICF) and were cross-referenced with data from similar studies using the Patient-Specific Functional Scale (PSFS) and the Patient-Specific Index for PD (PSI-PD). RESULTS: All 61 patients who participated in this study completed the COPM, and a total of 197 priorities were identified. The most frequently identified priorities were "Recreation and leisure," "Preparing meals," "Walking," "Doing housework," and "Caring for household objects." The priorities identified using the PSFS and the PSI-PD were less diverse and focused on "Mobility" or "Self-care." CONCLUSIONS: The COPM is a feasible and informative tool for identifying priorities in patients with PD. Its informativeness was demonstrated by its ability to identify diverse priorities across the ICF domains of "Activity and participation" that had not been identified in the studies using the PSFS and PSI-PD.

DOI： 10.1080/09593985.2021.2023926

PubMed

researchmap

Language：English   Publishing type：Research paper (scientific journal)  

Although mindfulness-based stress reduction (MBSR) improves cognitive function, the mechanism is not clear. In this study, people aged 65 years and older were recruited from elderly communities in Chitose City, Japan, and assigned to a non-MBSR group or a MBSR group. Before and after the intervention, the Japanese version of the Montreal Cognitive Assessment (MoCA-J) was administered, and blood samples were collected. Then, neuron-derived extracellular vesicles (NDEVs) were isolated from blood samples, and microRNAs, as well as the target mRNAs, were evaluated in NDEVs. A linear mixed model analysis showed significant effects of the MBSR x time interaction on the MoCA-J scores, the expression of miRNA(miR)-29c, DNA methyltransferase 3 alpha (DNMT3A), and DNMT3B in NDEVs. These results indicate that MBSR can improve cognitive function by increasing the expression of miR-29c and decreasing the expression of DNMT3A, as well as DNMT3B, in neurons. It was also found that intracerebroventricular injection of miR-29c mimic into 5xFAD mice prevented cognitive decline, as well as neuronal loss in the subiculum area, by down-regulating Dnmt3a  and Dnmt3b  in the hippocampus. The present study suggests that MBSR can prevent neuronal loss and cognitive impairment by increasing the neuronal expression of miR-29c.

DOI： 10.1038/s41598-021-01318-y

PubMed

researchmap

Authorship：Last author   Language：English   Publishing type：Research paper (scientific journal)  

PURPOSE: We aimed to translate the Early Clinical Assessment of Balance (ECAB) from English to Japanese and examine the content validity, inter-rater reliability, intra-rater reliability, construct validity, and minimal clinically important difference (MCID) for children with cerebral palsy (CP). METHODS: The ECAB was translated into Japanese per international standards. The study included 106 children with CP and, aged 1.5-12 years. The ECAB, the Gross Motor Function Classification System (GMFCS), and the Gross Motor Function Measure 66 Basal & Ceiling (GMFM-66-B&C) were measured. The content and construct validity were examined based on therapist feedback and correlations between the ECAB and GMFM-66-B&C. The inter-rater reliability and the intra-rater reliability were examined by the intra-class correlation coefficient (ICC). The MCID was calculated by the anchor-based method with the GMFM-66-B&C. RESULTS: High content validity (more than 80% agreement), inter-rater and intra-rater reliability (ICC = 0.99 & 0.99, respectively), and construct validity (r = 0.96) were demonstrated, with MCID values of 7.39, 5.32, and 6.88 observed for the GMFCS I/II, III, and IV/V, respectively. CONCLUSION: The Japanese version of the ECAB is a reliable and valid measure of balance ability in children with CP. Furthermore, the MCID of the ECAB was established, appears to be useful in helping to provide rehabilitation.Implications for RehabilitationThe Japanese version of the Early Clinical Assessment of Balance is easy, safe, and low-cost, and has high reliability and validity for assessing balance ability in children with cerebral palsy.The use of the Japanese version of the Early Clinical Assessment of Balance is beneficial for determining the therapeutic effect, appropriate treatment, and prediction of prognosis regarding balance ability in children with cerebral palsy.The minimal detectable change of the Japanese version of the ECAB suggest that a score exceeding 6 is a true change and the minimal clinically important difference of the Japanese version of the ECAB suggest that the scores exceeding 8, 6, and 7 for the GMFCS I/II, III, and IV/V, respectively, is a clinically useful change.

DOI： 10.1080/09638288.2021.1977859

PubMed

researchmap

Language：English   Publishing type：Research paper (scientific journal)  

OBJECTIVE: Quantitative data assessment on the basis of three-dimensional gait analysis has been routinely used in the evaluation of pathological gait of children with cerebral palsy. However, a similar quantitative methodology has not been applied for spina bifida patients in whom atypical gait patterns are thought to correlate with various levels of neurological paralysis. To investigate the differences among gait patterns in spina bifida between different levels of neurological lesions using quantitative methods: Gait profile score (GPS) and gait variable scores (GVS), scoring subject's gait deviation from a reference. METHODS: In this cross-sectional study, 22 children with spina bifida (11 women, 11 men; mean age 9.4 years, SD 3.8 years, range 3-17 years), were examined using three-dimensional gait analysis from 2008 to 2018. Physical examination allowed for classification of each of the 44 limbs as either L4, L5 or S1 and comparison with the GPS and GVS using a linear mixed model. RESULTS: GPS and the GVS of the pelvis and hip range of motion in the coronal plane were significantly higher in the L4 group than in the L5 and S1 groups (GPS, P = 0.041, P = 0.003, respectively; GVS of pelvis, P = 0.001, P = 0.001; GVS of hip, P < 0.001, P < 0.001) GVS (foot progression angle) was significantly lower in the S1 group than in L4 and L5 groups (P < 0.001, P = 0.037). CONCLUSIONS: We found that GPS and GVS enable us to quantitatively assess the differences among gait patterns between different neurological levels. The scoring tool showed the potential for detecting individual neurological changes.

DOI： 10.1097/BPB.0000000000000877

PubMed

researchmap

Language：English   Publishing type：Research paper (scientific journal)  

AIM: The aim of the present study was to investigate the effects of individualized nutritional treatment on the activities of daily living of acute stroke patients. METHODS: This was a randomized controlled study. The eligibility criteria were acute stroke, age >65 years and the presence of malnutrition risk. Between September 2016 and December 2017, 128 patients were assigned to either the standard or intensive group (individualized nutritional treatment). The intensive group received energy that was calculated using the Harris-Benedict equation. The main outcome measures were the total functional independence measurement gain from the time of assignment to the time of discharge from the recovery hospital or at 3 months after the stroke onset, and motor and cognitive functional independence measurement gains. RESULTS: Compared with the standard group, the intensive group had significantly higher median energy intake (P < 0.001); significantly greater functional independence measurement gains in the total score (42 vs. 22; P = 0.02) and motor subscore (P = 0.01), but similar cognitive subscore. CONCLUSION: Individualized nutritional treatment improved the activities of daily living of older acute stroke patients with malnutrition risk. Geriatr Gerontol Int 2019; ••: ••-••.

DOI： 10.1111/ggi.13854

PubMed

researchmap

Language：English   Publishing type：Research paper (scientific journal)  

AIM: We examined the association of muscle mass and muscle strength with insulin resistance, focusing on lower limb muscles. METHODS: This was a cross-sectional study, and participants were registered in 2017 from the Tanno-Sobetsu Study, a population-based cohort study. After excluding individuals aged <64 years or with a history of diabetes mellitus, 272 non-diabetic older adults (116 men, 156 women) met the inclusion criteria. According to the homeostasis model assessment of insulin resistance, the participants were divided into two groups; that is, the insulin resistance group (homeostasis model assessment of insulin resistance ≥1.73) and non-insulin resistance group (homeostasis model assessment of insulin resistance <1.73). Muscle mass (lower limb, upper limb, appendicular and trunk) and muscle strength (grip strength and knee extension torque) were measured and divided by the weight, and then multiplied by 100 to calculate the weight ratio (%). The adjusted odds ratio (OR) of each muscle index for risk of insulin resistance was calculated separately for both men and women. RESULTS: Lower limb muscle mass (OR 0.72, 95% CI 0.55-0.92 in men; OR 0.69, 95% CI 0.51-0.96 in women, respectively) and appendicular muscle mass (OR 0.75, 95% CI 0.61-0.94 in men; OR 0.72, 95% CI 0.54-0.95 in women, respectively), but not other muscle indexes, were associated with risk of insulin resistance, after adjusting for age, body mass index, highly sensitive C-reacting protein and smoking habits. CONCLUSIONS: Lower limb muscle mass of non-diabetic older adults is independently related to insulin resistance. Geriatr Gerontol Int 2019; 19: 1254-1259.

DOI： 10.1111/ggi.13805

PubMed

researchmap

Language：English   Publishing type：Research paper (scientific journal)  

Renin-angiotensin system (RAS) inhibitors are often used as a first-line treatment for hypertensive patients with diabetes because of purported benefits, such as reno-protection. However, there is no clear evidence for the superiority of RAS inhibitors to other classes of antihypertensives for clinically important outcomes in this population. We conducted a meta-analysis to assess whether RAS inhibitors are better than other classes of antihypertensives for reducing mortality, and cardiovascular and renal events in hypertensive patients with diabetes. From June to December 2017, we searched Medline, Cochrane Library, and the database of the Japan Medical Abstracts Society (ICHUSHI) for relevant published randomized controlled trials that directly compared the effects of RAS inhibitors to other classes of antihypertensives as first-line treatments for reducing adverse outcomes among hypertensive patients with diabetes. Our predetermined outcomes included all-cause death, cardiovascular death, incidence of cardiovascular disease, and renal dysfunction. We identified 16 trials, including a total of 35,052 patients. No significant benefits for RAS inhibitors were found compared to other classes of antihypertensives for all-cause death (relative risk (RR) 0.95, 95% confidence interval (CI) 0.85-1.05, p = 0.29), cardiovascular death (RR 0.84, 95% CI 0.68-1.04, p = 0.11), incidence of cardiovascular disease (RR 0.93, 95% CI 0.84-1.03, p = 0.16), and incidence of renal dysfunction (RR 0.91, 95% CI 0.77-1.06, p = 0.22). In conclusion, RAS inhibitors are not superior to other classes of antihypertensive drugs for reducing all-cause and cardiovascular mortalities, cardiovascular events, and renal events in hypertensive patients with diabetes.

DOI： 10.1038/s41440-019-0234-6

PubMed

researchmap

Language：English   Publishing type：Research paper (scientific journal)  

OBJECTIVE: For patients with acute coronary syndrome (ACS), percutaneous coronary intervention (PCI) within 120 minutes from onset is recommended. A helicopter emergency medical service (HEMS) is useful for transporting ACS patients. The purposes of this study were to investigate whether patients with ACS in the eastern part of Hokkaido could be transported to a PCI hospital by HEMS and undergo PCI within 120 minutes and to clarify the factors most related to delayed access to PCI. METHODS: This was a retrospective cohort study that analyzed 513 patients diagnosed with ACS at our institution, an HEMS base/PCI hospital. We investigated transport modes for each patient and identified the processes by which access to PCI was delayed. RESULTS: HEMS reduced transport time compared with ground emergency medical services but did not contribute to access to PCI within 120 minutes. The most important factor was transport directly to a PCI hospital (P < .01). CONCLUSION: HEMS did not achieve a total transport time of patients to a PCI hospital within 120 minutes from onset. Transport using HEMS is insufficient to access early PCI; patient condition must also be considered to determine whether to go through a non-PCI hospital.

DOI： 10.1016/j.amj.2018.11.008

PubMed

researchmap

Authorship：Lead author,　Corresponding author   Language：English   Publishing type：Research paper (scientific journal)  

Aims: To determine the structural validity, construct validity, cross-cultural validity, internal consistency and test-retest reliability of the Japanese version of the ABILOCO-Kids in children with cerebral palsy. Methods: One-hundred sixteen parents of children with cerebral palsy (Gross Motor Function Classification System level I [n = 66], II [n = 32], and III [n = 18]) reported on walking ability using the Japanese version of the ABILOCO-Kids. For test-retest reliability, 23 participants were evaluated. Results: The mean ABILOCO-Kids logit score was 2.48 (range -7.44 to 5.83). Rasch analysis and principal component analysis were used to determine the structural validity. The construct validity was confirmed on the basis of differences in the ABILOCO-Kids scores among the Gross Motor Function Classification System levels. Cronbach's α and the item-to-total correlation coefficient supported the internal consistency. The intra-class correlation coefficient was 0.96, standard error of measurement 0.56 and minimal detectable change 1.55. The cross-cultural validity analyses showed differential item functioning according to the analyses of the invariance of item difficulty and person's ability estimates. Conclusions: The ABILOCO-Kids is a reliable and valid measure of walking ability in children with cerebral palsy in Japan. The lack of evidence on cross-cultural validity indicates we should interpret results cautiously in cases of international comparison.

DOI： 10.1080/01942638.2019.1609150

PubMed

researchmap

Publishing type：Research paper (scientific journal)   Publisher：Ovid Technologies (Wolters Kluwer Health)  

DOI： 10.1519/JPT.0000000000000207

PubMed

researchmap

Language：English   Publishing type：Research paper (scientific journal)  

Although the cognitive impairment in Alzheimer's disease (AD) is believed to be caused by amyloid-β (Aβ) plaques and neurofibrillary tangles (NFTs), several postmortem studies have reported cognitive normal subjects with AD brain pathology. As the mechanism underlying these discrepancies has not been clarified, we focused the neuroprotective role of astrocytes. After examining 47 donated brains, we classified brains into 3 groups, no AD pathology with no dementia (N-N), AD pathology with no dementia (AD-N), and AD pathology with dementia (AD-D), which represented 41%, 21%, and 38% of brains, respectively. No differences were found in the accumulation of Aβ plaques or NFTs in the entorhinal cortex (EC) between AD-N and AD-D. Number of neurons and synaptic density were increased in AD-N compared to those in AD-D. The astrocytes in AD-N possessed longer or thicker processes, while those in AD-D possessed shorter or thinner processes in layer I/II of the EC. Astrocytes in all layers of the EC in AD-N showed enhanced GLT-1 expression in comparison to those in AD-D. Therefore these activated forms of astrocytes with increased GLT-1 expression may exert beneficial roles in preserving cognitive function, even in the presence of Aβ and NFTs.

DOI： 10.1038/s41598-018-19442-7

PubMed

researchmap

Authorship：Lead author,　Corresponding author   Language：English   Publishing type：Research paper (scientific journal)  

BACKGROUND: The prognosis for mobility function by Gross Motor Function Classification System (GMFCS) level is vital as a guide to rehabilitation for people with cerebral palsy. OBJECTIVE: This study sought to investigate change in mobility function and its causes in adults with cerebral palsy by GMFCS level. METHODS: We conducted a cross-sectional questionnaire study. RESULTS: A total of 386 participants (26 y 8 m, SD 5 y 10 m) with cerebral palsy were analyzed. Participant numbers by GMFCS level were: I (53), II (139), III (74) and IV (120). The median age of participants with peak mobility function in GMFCS level III was younger than that in the other levels. 48% had experienced a decline in mobility. A Kaplan-Meier plot showed the risk of mobility decline increased in GMFCS level III; the hazard ratio was 1.97 (95% CI, 1.20-3.23) compared with level I. The frequently reported causes of mobility decline were changes in environment, and illness and injury in GMFCS level III, stiffness and deformity in level IV, and reduced physical activity in level II and III. CONCLUSIONS: Peak mobility function and mobility decline occurred at a younger age in GMFCS level III, with the cause of mobility decline differing by GMFCS level.

DOI： 10.3233/NRE-172340

PubMed

researchmap

Authorship：Lead author,　Corresponding author   Language：English   Publishing type：Research paper (scientific journal)  

DOI： 10.1016/j.ridd.2017.07.004

PubMed

Web of Science

researchmap

Language：English   Publishing type：Research paper (scientific journal)  

DOI： 10.1111/ped.13266

PubMed

Web of Science

researchmap

Authorship：Lead author,　Corresponding author   Language：English   Publishing type：Research paper (scientific journal)  

DOI： 10.1080/09638288.2016.1175036

PubMed

Web of Science

researchmap

Language：English   Publishing type：Research paper (scientific journal)  

DOI： 10.1097/MRR.0000000000000205

PubMed

Web of Science

researchmap

Language：English   Publishing type：Research paper (scientific journal)  

DOI： 10.1007/s10120-015-0557-1

PubMed

Web of Science

researchmap

Authorship：Lead author,　Corresponding author   Language：English   Publishing type：Research paper (scientific journal)  

DOI： 10.1038/jp.2014.204

PubMed

Web of Science

researchmap

Authorship：Lead author,　Corresponding author   Language：English   Publishing type：Research paper (scientific journal)  

DOI： 10.1111/j.1365-2214.2012.01371.x

PubMed

Web of Science

researchmap

Total pages：208   Responsible for pages：77-88  

ASIN

researchmap

Language：Japanese   Publisher：(一社)日本小児理学療法学会  

Ichushi

researchmap

Language：Japanese   Publisher：(一社)日本小児理学療法学会  

Other Link:： https://search.jamas.or.jp/default/link?pub_year=2023&ichushi_jid=J07741&link_issn=&doc_id=20230428370028&doc_link_id=10.60187%2Fjjppt.1.Supplement_1_38&url=https%3A%2F%2Fdoi.org%2F10.60187%2Fjjppt.1.Supplement_1_38&type=J-STAGE&icon=https%3A%2F%2Fjk04.jamas.or.jp%2Ficon%2F00007_3.gif

Ichushi

researchmap

Language：Japanese   Publisher：(一社)日本小児理学療法学会  

Ichushi

researchmap

Language：Japanese   Publisher：(一社)日本小児理学療法学会  

Other Link:： https://search.jamas.or.jp/default/link?pub_year=2023&ichushi_jid=J07741&link_issn=&doc_id=20230428370107&doc_link_id=10.60187%2Fjjppt.1.Supplement_1_117&url=https%3A%2F%2Fdoi.org%2F10.60187%2Fjjppt.1.Supplement_1_117&type=J-STAGE&icon=https%3A%2F%2Fjk04.jamas.or.jp%2Ficon%2F00007_3.gif

Ichushi

researchmap

Language：Japanese   Publisher：(一社)日本小児理学療法学会  

Other Link:： https://search.jamas.or.jp/default/link?pub_year=2023&ichushi_jid=J07741&link_issn=&doc_id=20230428380045&doc_link_id=10.60187%2Fjjppt.1.Supplement_2_61&url=https%3A%2F%2Fdoi.org%2F10.60187%2Fjjppt.1.Supplement_2_61&type=J-STAGE&icon=https%3A%2F%2Fjk04.jamas.or.jp%2Ficon%2F00007_3.gif

Ichushi

researchmap

Language：Japanese   Publisher：(一社)日本小児理学療法学会  

Other Link:： https://search.jamas.or.jp/default/link?pub_year=2023&ichushi_jid=J07741&link_issn=&doc_id=20230428380025&doc_link_id=10.60187%2Fjjppt.1.Supplement_2_41&url=https%3A%2F%2Fdoi.org%2F10.60187%2Fjjppt.1.Supplement_2_41&type=J-STAGE&icon=https%3A%2F%2Fjk04.jamas.or.jp%2Ficon%2F00007_3.gif

Ichushi

researchmap

Language：Japanese   Publisher：(一社)日本小児理学療法学会  

Other Link:： https://search.jamas.or.jp/default/link?pub_year=2023&ichushi_jid=J07741&link_issn=&doc_id=20230428370030&doc_link_id=10.60187%2Fjjppt.1.Supplement_1_40&url=https%3A%2F%2Fdoi.org%2F10.60187%2Fjjppt.1.Supplement_1_40&type=J-STAGE&icon=https%3A%2F%2Fjk04.jamas.or.jp%2Ficon%2F00007_3.gif

Ichushi

researchmap

Language：Japanese   Publisher：(NPO)日本高血圧学会  

Ichushi

researchmap

Language：Japanese   Publisher：(公社)日本新生児成育医学会  

Ichushi

researchmap

Language：Japanese   Publisher：(公社)日本理学療法士協会  

Ichushi

researchmap

Language：Japanese   Publisher：(一社)日本理学療法学会連合  

Ichushi

researchmap

Language：Japanese   Publisher：(一社)日本理学療法学会連合  

Ichushi

researchmap

Language：Japanese   Publisher：(公社)日本理学療法士協会  

Ichushi

researchmap

Language：Japanese   Publisher：(一社)日本理学療法学会連合  

Ichushi

researchmap

Language：Japanese   Publisher：(公社)日本理学療法士協会  

Ichushi

researchmap

Language：Japanese   Publisher：(一社)日本循環器病予防学会  

Ichushi

researchmap

Language：Japanese   Publisher：(株)医学出版  

Ichushi

researchmap

Language：Japanese   Publisher：(公社)日本整形外科学会  

Ichushi

researchmap

J-GLOBAL

researchmap

Language：Japanese   Publisher：(一社)日本老年医学会  

Ichushi

J-GLOBAL

researchmap

Language：Japanese   Publisher：(NPO)日本高血圧学会  

Ichushi

researchmap

Language：Japanese   Publisher：日本保健科学学会  

Ichushi

researchmap

Language：Japanese   Publisher：(公社)日本理学療法士協会  

Ichushi

researchmap

Language：Japanese   Publisher：医学図書出版(株)  

Ichushi

researchmap

Language：Japanese   Publisher：(一社)日本足の外科学会  

Ichushi

researchmap

Language：Japanese   Publisher：(株)先端医学社  

Ichushi

J-GLOBAL

researchmap

Language：Japanese   Publisher：医学図書出版(株)  

Ichushi

researchmap

Language：Japanese   Publisher：(株)先端医学社  

Ichushi

researchmap

Language：Japanese   Publishing type：Research paper, summary (national, other academic conference)  

researchmap

Language：Japanese   Publisher：(一社)日本循環器病予防学会  

Ichushi

researchmap

Language：English   Publisher：日本医療大学  

Ichushi

researchmap

Language：Japanese   Publisher：北海道公衆衛生協会  

CiNii Research

researchmap

Language：Japanese   Publisher：北海道開発協会開発調査総合研究所  

CiNii Research

researchmap

J-GLOBAL

researchmap

Language：Japanese   Publisher：(一社)日本糖尿病合併症学会  

Ichushi

researchmap

Language：Japanese   Publisher：(福)日本肢体不自由児協会  

Ichushi

researchmap

Language：Japanese   Publisher：(一社)日本循環器病予防学会  

Ichushi

researchmap

Language：Japanese   Publisher：(NPO)日本高血圧学会  

Ichushi

researchmap

Language：Japanese   Publisher：(株)医学書院  

Ichushi

researchmap

Language：Japanese   Publisher：(一社)日本認知症学会  

Ichushi

researchmap

Language：Japanese   Publisher：日本脳性麻痺の外科研究会事務局  

Ichushi

researchmap

Language：Japanese   Publisher：(一社)日本循環器病予防学会  

Ichushi

researchmap

Language：Japanese   Publisher：(公社)日本理学療法士協会  

Ichushi

researchmap

Language：Japanese   Publisher：(公社)日本理学療法士協会  

Ichushi

researchmap

Language：Japanese   Publisher：(公社)日本理学療法士協会  

Ichushi

researchmap

Language：Japanese   Publisher：(公社)日本理学療法士協会  

Ichushi

researchmap

Language：Japanese   Publisher：(公社)日本理学療法士協会  

Ichushi

researchmap

Language：Japanese   Publisher：(公社)日本理学療法士協会  

Ichushi

researchmap

Language：Japanese   Publisher：北海道公衆衛生学会  

Ichushi

researchmap

Language：Japanese   Publisher：(公社)北海道理学療法士会  

Ichushi

researchmap

Language：Japanese   Publisher：(公社)日本理学療法士協会  

Ichushi

researchmap

J-GLOBAL

researchmap

Language：Japanese   Publisher：フランスベッド・メディカルホームケア研究・助成財団  

researchmap

Language：Japanese   Publisher：(公社)日本新生児成育医学会  

Ichushi

researchmap

Language：Japanese   Publisher：(公社)日本理学療法士協会  

Ichushi

researchmap

J-GLOBAL

researchmap

J-GLOBAL

researchmap

Language：Japanese   Publisher：(株)医学書院  

Other Link:： https://search.jamas.or.jp/index.php?module=Default&action=Link&pub_year=2011&ichushi_jid=J00780&link_issn=&doc_id=20110714130016&doc_link_id=10.11477%2Fmf.1552102136&url=https%3A%2F%2Fdoi.org%2F10.11477%2Fmf.1552102136&type=%88%E3%8F%91.jp_%83I%81%5B%83%8B%83A%83N%83Z%83X&icon=https%3A%2F%2Fjk04.jamas.or.jp%2Ficon%2F00024_2.gif

Ichushi

researchmap

Language：Japanese   Publisher：(公社)日本理学療法士協会  

Ichushi

researchmap

Language：Japanese   Publishing type：Article, review, commentary, editorial, etc. (scientific journal)   Publisher：(公社)日本理学療法士協会  

Other Link:： https://search-tp.jamas.or.jp/index.php?module=Default&action=Link&pub_year=2009&ichushi_jid=J01747&link_issn=&doc_id=20090706380023&doc_link_id=%2Fcb3physi%2F2009%2F003604%2F024%2F0232-0235%26dl%3D0&url=https%3A%2F%2Fwww.medicalonline.jp%2Fjamas.php%3FGoodsID%3D%2Fcb3physi%2F2009%2F003604%2F024%2F0232-0235%26dl%3D0&type=MedicalOnline&icon=https%3A%2F%2Fjk04.jamas.or.jp%2Ficon%2F00004_2.gif

Ichushi

researchmap

Language：Japanese   Publisher：日本重症心身障害学会  

Ichushi

researchmap

Language：Japanese   Publisher：日本重症心身障害学会  

Ichushi

researchmap

Language：Japanese   Publisher：日本重症心身障害学会  

Ichushi

researchmap

Language：Japanese   Publisher：(公社)北海道理学療法士会  

Ichushi

researchmap

Language：Japanese   Publisher：(公社)北海道理学療法士会  

Ichushi

researchmap

Language：Japanese   Publisher：(公社)北海道理学療法士会  

Ichushi

researchmap

Language：Japanese   Publisher：日本重症心身障害学会  

Ichushi

researchmap

Language：Japanese   Publisher：日本重症心身障害学会  

Ichushi

researchmap

Language：Japanese   Publisher：日本重症心身障害学会  

Ichushi

researchmap

Language：Japanese   Publisher：日本重症心身障害学会  

Ichushi

researchmap

Language：Japanese   Publisher：(公社)北海道理学療法士会  

Ichushi

researchmap

Language：Japanese   Publisher：(公社)北海道理学療法士会  

Ichushi

researchmap

Language：Japanese   Publisher：北海道リハビリテーション学会  

Ichushi

researchmap

Language：Japanese   Publisher：日本基礎理学療法学雑誌編集委員会  

Ichushi

researchmap

researchmap