2025/08/22 更新

写真a

ヒムロ　ノブアキ
樋室　伸顕
所属
医学部 社会医学講座公衆衛生学分野 准教授
職名
准教授
ORCID ID
0000-0003-2609-0510
外部リンク

研究キーワード

  • 理学療法

  • 公衆衛生

  • 移動能力

  • リハビリテーション

  • 評価尺度

  • 家族

  • 脳性麻痺

  • 疫学

研究分野

  • ライフサイエンス / 衛生学、公衆衛生学分野：実験系を含まない

  • ライフサイエンス / リハビリテーション科学

  • ライフサイエンス / 医療管理学、医療系社会学

  • ライフサイエンス / 衛生学、公衆衛生学分野：実験系を含む

学歴

  • 札幌医科大学   医学研究科   博士課程

    2010年4月 - 2013年3月

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  • 札幌医科大学   保健医療学研究科   博士課程前期

    2008年4月 - 2010年3月

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  • 札幌医科大学   保健医療学部   理学療法学科

    1996年4月 - 2000年3月

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経歴

  • 札幌医科大学   医学部公衆衛生学講座   准教授

    2022年12月 - 現在

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  • 札幌医科大学   医学部公衆衛生学講座   講師

    2015年4月 - 2022年11月

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  • 札幌医科大学   医学部公衆衛生学講座   助教

    2013年4月 - 2015年3月

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委員歴

  • 前立腺癌診療ガイドライン2023   システマティック・レビュー支援チーム  

    2023年10月   

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  • デジタル技術を活用した血圧管理に関する指針2025   システマティック・レビュー委員  

    2023年8月 - 現在   

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  • 尿路結石症診療ガイドライン第3版   文献検索チーム  

    2023年8月   

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  • 日本小児理学療法学会   評議員  

    2021年9月 - 現在   

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  • 北海道公衆衛生学会   評議員  

    2014年12月 - 現在   

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    団体区分：学協会

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論文

  • Application of the Gross Motor Function Measure in children with conditions other than cerebral palsy: A systematic review. 査読 国際誌

    Hirokazu Abe, Shuhei Higashi, Nobuaki Himuro

    Developmental medicine and child neurology   2025年8月

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    担当区分：最終著者,　責任著者   記述言語：英語   掲載種別：研究論文（学術雑誌）  

    AIM: To investigate the application and evaluate the measurement properties of the Gross Motor Function Measure (GMFM) in children with conditions other than cerebral palsy (CP). METHOD: A systematic review was conducted using five electronic databases to identify studies that used the GMFM in children with conditions other than CP. Methodological quality and measurement properties were evaluated using established standards for assessing outcome measures. RESULTS: We identified 210 studies across various paediatric conditions. Measurement property studies examined eight conditions: acquired brain injury, spinal muscular atrophy, Fukuyama congenital muscular dystrophy, Down syndrome, osteogenesis imperfecta, acute lymphoblastic leukaemia (ALL), leukodystrophy, and Pompe disease. Evidence quality was generally low to very low owing to small sample sizes and methodological limitations. Reliability showed sufficient ratings across most conditions. Content validity was examined only for ALL and demonstrated sufficient ratings. Responsiveness and construct validity showed variable results across conditions. Clinical application analysis revealed inadequate methodological reporting and widespread use without appropriate validation. INTERPRETATION: GMFM validation for conditions other than CP remains insufficient despite widespread use. Content validity verification and enhanced methodological rigor are critically needed. Clinicians should interpret results cautiously until robust validation is established.

    DOI： 10.1111/dmcn.16465

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  • Low skeletal muscle mass independently predicts the progression of insulin resistance in non-obese older adults: a six-year cohort study 査読

    Toshiaki Seko, Nobuaki Himuro, Masayuki Koyama, Kei Nakata, Hiroshi Akasaka, Mitsuru Mori, Shunichi Ogawa, Sayo Miura, Hirofumi Ohnishi

    Diabetology International   2025年8月

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    掲載種別：研究論文（学術雑誌）   出版者・発行元：Springer Science and Business Media LLC  

    その他リンク： https://link.springer.com/article/10.1007/s13340-025-00843-9/fulltext.html

    DOI： 10.1007/s13340-025-00843-9

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  • Effects of physical activity-promoting wearable devices on blood pressure in adults: a systematic review and meta-analysis. 査読 国際誌

    Masayuki Koyama, Nobuaki Himuro, Kei Nakata, Keisuke Oyatani, Yukiko Shinohara, Hirofumi Ohnishi, Hisatomi Arima

    Hypertension research : official journal of the Japanese Society of Hypertension   2025年7月

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    記述言語：英語   掲載種別：研究論文（学術雑誌）  

    Hypertension affects more than 4 billion people worldwide and is a major risk factor for cardiovascular disease. Improving physical activity is an effective way to manage hypertension, and there has been a lot of interest in the use of wearable devices for promoting physical activity, which have become increasingly popular in recent years, but in many countries, improvements in physical activity levels remain inadequate. This systematic review and meta-analysis investigated whether interventions using wearable devices have a beneficial effect on blood pressure in adults. Following PRISMA 2020 guidelines and registered with PROSPERO (CRD42023442506), we searched PubMed, MEDLINE, Cochrane Library, and IchuShi-Web, identifying 21 randomized controlled trials including participants with hypertension, type 2 diabetes, or overweight/obesity. Interventions ranged from 12 to 48 weeks using pedometers, activity trackers, and smartwatches. Random-effects meta-analysis showed these interventions did not produce statistically significant improvements in systolic or diastolic blood pressure at any intervention duration (12, 24, or 48 weeks). Similarly, no statistically significant improvements were found in secondary outcomes (body weight, fasting blood glucose, and Hemoglobin A1c). Heterogeneity varied from low to high depending on outcome and intervention period. These findings indicate that evidence of direct intervention using wearable devices for promoting physical activity alone is currently insufficient to establish clinically meaningful improvements in blood pressure and related metabolic parameters. Future research may need to integrate wearable technology into comprehensive care models that combine targeted feedback and education with behavioral support strategies, rather than direct intervention through monitoring alone.

    DOI： 10.1038/s41440-025-02260-6

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  • Inter- and intra-rater reliability, construct validity and feasibility of the independently get off the floor scoring system for Japanese stroke survivors. 査読 国際誌

    Eiji Kobayashi, Yoshihiko Shibukawa, Tomoyasu Sakaguchi, Sayo Miura, Hirohumi Kamiyama, Akane Shimoyama, Yuri Ishikawa, Youhei Muraoka, Nobuaki Himuro

    Topics in stroke rehabilitation   1 - 11   2025年7月

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    担当区分：最終著者   記述言語：英語   掲載種別：研究論文（学術雑誌）  

    BACKGROUND: Although assessment of the capacity to get up from the floor after a fall is considered beneficial in maintaining physical safety for stroke survivors, measurement properties of the Independently Get Off the Floor Scoring System (IGO) for this population is not well established. OBJECTIVE: To translate the IGO into Japanese, and to investigate reliability, construct validity, and feasibility of it for stroke survivors. DESIGN: Sixty-five Japanese stroke survivors participated in this study. This study was designed based on COSMIN standards. The IGO was translated into Japanese using forward and backward translation. For the inter- and intra-rater reliability, weighted Cohen's kappa values and Fleiss's kappa values were used. For the construct validity, hypotheses testing method was used. Correlations between the IGO and standard measurements, the Stroke Impairment Assessment Set, knee extensor muscle strength, range of motion in the shoulder and ankle joint, the 5-repetition Sit-To-Stand test, and the Timed Up and Go test were examined using the Spearman's rank correlation coefficient. RESULTS: The IGO demonstrates moderate inter-rater reliability between three raters (κ = 0.620) and strong to almost perfect reliability between two raters (κ = 0.824 to 0.862) and strong to almost perfect intra-rater reliability for each rater (κ = 0.884 to 0.959). Seven of 8 hypotheses to test construct validity were confirmed. The significant correlation coefficients obtained ranged from 0.345 to 0.633. CONCLUSIONS: The IGO is a reliable, valid, and feasible measurement to assess the capacity of stroke survivors to get up from the floor.

    DOI： 10.1080/10749357.2025.2532409

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  • The Japanese Version of the Quality of Upper Extremity Skills Test. 査読 国際誌

    Sayaka Katori, Nobuaki Himuro, Masaki Miura, Yukihiro Kitai, Ryo Tanabe, Hirofumi Ohnishi

    OTJR : occupation, participation and health   15394492251349161 - 15394492251349161   2025年6月

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    担当区分：責任著者   記述言語：英語   掲載種別：研究論文（学術雑誌）  

    To improve upper-limb function in children with cerebral palsy (CP), adequate assessment tools are essential for rehabilitation; however, there have been very few assessment tools with acceptable validity and reliability for use in Japan to date. The aim of this study was to describe the process of translating the Quality of Upper Extremity Skills Test (QUEST) into Japanese and to examine its psychometric properties. The QUEST was translated using a forward-backward method. Sixty-one children aged 2-18 years with a diagnosis of CP underwent assessment, with video-based reliability assessments conducted for 38 of them. The intra-class correlation coefficients were 0.94 for inter-rater reliability and 0.97 for intra-rater reliability. The total score showed a strong correlation with the Manual Ability Classification System (ρ = -0.65). A questionnaire of experts showed generally good content validity. The Japanese version of the QUEST was found to be both valid and reliable.

    DOI： 10.1177/15394492251349161

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  • Reliability of walking ability measurements in children with cerebral palsy: A mixed-methods study 査読

    Tsugumi Hosokawa Seino, Hisato Nishibu, Nobuaki Himuro, Naoki Kozuka

    Physiotherapy Practice and Research: The Official Journal of The Irish Society of Chartered Physiotherapists   2025年4月

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    担当区分：責任著者   掲載種別：研究論文（学術雑誌）   出版者・発行元：SAGE Publications  

    Objective

    This study aimed to compare the reliability of the Timed Up and Go Test (TUG) and 1-Minute Walk Test (1MWT) in children with cerebral palsy (CP); tests were administered by clinically experienced physiotherapists and physiotherapy students.

    Methods

    In this mixed-methods study, 30 ambulatory children (mean age: 13 years) with CP were administered TUG and 1MWT by five licensed physiotherapists and 18 physiotherapy students.

    Results

    The intraclass correlation coefficient for inter-rater reliability between the physiotherapists and students was 0.99 (95% confidence interval [CI]: 0.98–0.99) for TUG and 0.92 (95% CI: 0.83–0.96) for 1MWT. Α Bland–Altman analysis identified a fixed bias in the negative and positive directions for TUG and 1MWT, respectively. Statistical analysis revealed a proportional bias in TUG. A qualitative analysis showed that while physiotherapists followed the instruction manual and provided clear instructions, the students did not follow the manual and were tense, triggering a negative response from the children.

    Conclusions

    The difference in clinical experience of professionals administering the TUG and 1MWT to children with CP impacted measurement outcomes. In contrast to physiotherapy students, more experienced physiotherapists ensured that the child was not anxious, provided clear instructions, and performed measurements as per the manual.

    その他リンク： https://journals.sagepub.com/doi/full-xml/10.1177/22130683251337328

    DOI： 10.1177/22130683251337328

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  • Current Evidence in Knee-Ankle-Foot Orthosis Therapy for Patients with Stroke: A Systematic Review of Observational Studies 査読

    Eiji Kobayashi, Kenta Hiratsuka, Hirokazu Haruna, Nobue Kojima, Nobuaki Himuro

    JPO Journal of Prosthetics and Orthotics   37 ( 2 )   e38 - e45   2025年4月

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    担当区分：最終著者   掲載種別：研究論文（学術雑誌）   出版者・発行元：Ovid Technologies (Wolters Kluwer Health)  

    ABSTRACT

    Introduction

    Although knee-ankle-foot orthosis (KAFO) therapy is considered effective for improving functional mobility in patients with stroke, the certainty of the evidence remains unclear.

    Objective

    The aim of this study was to determine the certainty of evidence of treatment effect of KAFO therapy, the methodological quality, and the current status of KAFO therapy in patients with stroke based on existing research.

    Methods

    Data from studies that examined the treatment effect of KAFO on functional mobility or activities of daily living in patients with stroke were searched on seven databases: PubMed, CINAHL, Scopus, CENTRAL, PEDro, WoS, and Igaku Chuo Zassi. The results were reported according to the Preferred Reporting Items for Systematic Review and Meta-Analyses (PRISMA) statement. The overall status of KAFO therapy was summarized descriptively. The certainty of the evidence was assessed using the Grading of Recommendations, Assessment, Development, and Evaluation (GRADE) approach. Methodological quality was assessed using the STROBE statement.

    Results

    Three observational studies were included in the analysis, but no random controlled trials (RCTs) were identified. The certainty of the evidence for treatment effect of KAFO therapy in stroke was very low. The included studies did not adequately control potential confounders. The treatment effects of KAFO therapy for different levels of lower-limb paralysis and those on walking ability outcomes remain unclear.

    Conclusions

    The lack of RCTs limits the evidence for the treatment effect of KAFO therapy in patients with stroke. This systematic review of observational studies highlights the low certainty of current evidence and identifies key areas for improvement in future research.

    Clinical Relevance

    This is the first systematic review of observational studies to elucidate current evidence of the treatment effect of KAFOs in patients with stroke. KAFOs may improve functional mobility and activities of daily living; however, the certainty of the evidence is very low, and high-quality trials are needed to establish the benefits of KAFO therapy for these patients.

    DOI： 10.1097/jpo.0000000000000552

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  • Self-suppressing behavioral patterns and depressive traits exacerbate chronic pain: Psychological trait assessment using the structured association technique method. 査読 国際誌

    Shin Hashizume, Masako Nakano, Chihiro Ikehata, Nobuaki Himuro, Kanna Nagaishi, Mineko Fujimiya

    PloS one   20 ( 3 )   e0319647   2025年

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    記述言語：英語   掲載種別：研究論文（学術雑誌）  

    This study investigated the relationship between psychological traits and chronic pain using the Structured Association Technique (SAT) method to evaluate psychological factors associated with chronic pain. The participants included 105 older adults (23 men, 82 women, mean age 80.82 years) who received rehabilitation services. Chronic pain severity was assessed using a numerical rating scale (NRS), and psychological traits were evaluated by SAT. In addition, maternal attachment experiences in childhood were examined. The NRS showed significant positive correlations with the self-suppressing behavioral pattern (S) scale (r =  0.31, p =  0.001), and the depression (D) scale (r =  0.31, p =  0.001). The proportion of participants with high scores on both the S and D scales (SD group) was notably higher in the high NRS group. Logistic regression analysis showed that the SD group had a higher odds ratio (OR =  8.469, p =  0.004) for severe chronic pain, suggesting that SD traits independently contribute to worse pain. In the SD group, the self-denial scale scores were high, and self-denial traits showed a negative correlation with maternal attachment experiences in childhood. This finding indicates that poor maternal attachment may enhance self-denial traits, which in turn indirectly worsen pain through their effects on S and D traits. The results of this study highlight the importance of S and D traits as psychological factors in chronic pain, particularly in Japanese populations, and suggest that assessing self-suppressing behavioral patterns may be beneficial for pain management. However, the cross-cultural validity of the SAT scales requires further investigation. SAT therapy may provide a comprehensive approach to the treatment and prevention of complex conditions influenced by psychological and social factors, including chronic pain.

    DOI： 10.1371/journal.pone.0319647

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  • Maternal age and the rising incidence of hypertensive disorders of pregnancy: A comprehensive analysis of national claims data from Japan. 査読 国際誌

    Naomi Maeda, Masayuki Koyama, Shintaro Takatsuka, Keisuke Oyatani, Nobuaki Himuro, Tasuku Mariya, Yoshika Kuno, Shiro Hinotsu, Tsuyoshi Saito, Hirofumi Ohnishi

    PloS one   20 ( 2 )   e0319177   2025年

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    記述言語：英語   掲載種別：研究論文（学術雑誌）  

    BACKGROUND: Hypertensive disorders of pregnancy (HDP) significantly increase the risk of developing hypertension and cardiovascular disease (CVD) later in life and are a major cause of maternal mortality. However, little is known about the nationwide, long-term, all-inclusive status of HDP. OBJECTIVE: To estimate the incidence of HDP from 2011 to 2019 in Hokkaido, Japan, with a focus on age groups. METHODS: Using National Database (NDB) insurance medical data, a retrospective analysis was conducted. Due to the absence of direct pregnancy data, birth numbers were used as a surrogate for the number of pregnant women to calculate the incidence of HDP. RESULTS: The average incidence rate of HDP over 9 years was 6.37%. The incidence rate was lowest among women aged 25-29 years, at 5.58% (95% confidence interval [CI]: 5.43-5.73), and increased with age, peaking at 10.58% (95% CI: 10.10-11.09) among women over 40 years. Notably, the incidence rate for women under 20 years of age was 6.70% (95% CI: 5.97-7.51), which was higher than that for women in their 20s. A mean annual increase of 0.25% in age-adjusted incidence was observed during this period, which was statistically significant (R² =  0.87, p <  0.01). CONCLUSION: This study reveals that the risk of developing HDP is associated with both older childbearing and younger pregnancies and follows a J-curve, suggesting that factors other than maternal aging also contribute to the increased incidence of HDP and that further research on risk factors for HDP, which is on the rise worldwide, is urgently needed.

    DOI： 10.1371/journal.pone.0319177

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  • Prehospital emergency care family satisfaction scale for care provided by emergency medical technicians: Scale development and validation. 査読 国際誌

    Junpei Haruna, Shuji Uemura, Nobuyasu Hayasaka, Yukiko Taguchi, Saori Muranaka, Sachi Niiyama, Hirotoshi Inamura, Keigo Sawamoto, Hirotoshi Mizuno, Nobuaki Himuro, Eichi Narimatsu

    Journal of evaluation in clinical practice   2024年7月

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    記述言語：英語   掲載種別：研究論文（学術雑誌）  

    RATIONALE: To date, family satisfaction with emergency medical technicians (EMTs) has only been reported through narrative statements in subjective evaluations. Although a quantitative assessment of healthcare professional satisfaction is desirable, no specific measures have been devised to assess family satisfaction with the healthcare and care provided by EMTs. AIMS AND OBJECTIVES: This study aimed to develop and validate an EMT care family satisfaction scale to measure patient satisfaction with prehospital emergency care. METHODS: The study population comprised 216 family members (N = 216) of patients who used ambulances between November 2020 and May 2021 in a single region in Japan. Questionnaires were distributed to the participants who provided informed consent. An exploratory factor analysis of construct validity was performed to validate the Family Satisfaction Scale. The Cronbach's alpha was used to validate the internal consistency reliability of the scale. RESULTS: The exploratory factor analysis results revealed a four-factor structure: 'explanation and communication,' 'physical treatment,' 'psychological support,' and 'environment in the ambulance.' The Cronbach's range (0.80-0.93) for the total score for each of these four factors and the overall total score confirmed favorable internal reliability of this study. CONCLUSIONS: The family satisfaction scale developed in this study was constructed and validated to highlight the role of EMTs and needs of the families in the prehospital care settings. Moreover, this scale can be applied in the evaluation and consideration of interventions to improve family satisfaction with EMTs.

    DOI： 10.1111/jep.14090

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  • Cross-cultural adaptation, validity and reliability of the Japanese version of ABILHAND-kids for children with cerebral palsy using Rasch measurement model. 査読 国際誌

    Sayaka Katori, Nobuaki Himuro, Yukihiro Kitai, Ryo Tanabe, Hirofumi Ohnishi

    Disability and rehabilitation   1 - 9   2024年4月

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    担当区分：責任著者   記述言語：英語   掲載種別：研究論文（学術雑誌）  

    PURPOSE: The aim of this study was to develop the Japanese version of the ABILHAND-Kids and to examine its psychometric properties for Japanese children with cerebral palsy (CP). METHODS: The experimental version of 75 items was developed using forward-backward translation method. Parents of 137 children with CP answered it. Their responses were analyzed to successive items, and psychometric properties of the final version were investigated through the Rasch measurement model. RESULTS: The Japanese version of the ABILHAND-Kids contained 22 items. It showed valid item-patient targeting, no significant floor and ceiling effects, and no differential item functioning for demographic and clinical subgroups. All items contributed to the definition of one-dimensional measure. For internal consistency, the person separation index was 0.94. For test-retest reliability, the intraclass correlation coefficients were 0.96 (95% CI: 0.92-0.98). The minimal detectable difference was calculated with a logit score of 0.79 and a total raw score of 4.50. The logit score showed a strong correlation with the Manual Ability Classification System level (ρ= -0.70) and the Gross Motor Function Classification System level (ρ= -0.62). CONCLUSIONS: The Japanese version of the ABILHAND-Kids was found to be valid and reliable. It appears to be a good tool for assessing manual abilities in daily activities in children with CP.

    DOI： 10.1080/09638288.2024.2338201

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  • The Contributions of Knee Extension Strength and Hand Grip Strength to Factors Relevant to Physical Frailty: The Tanno-Sobetsu Study. 査読 国際誌

    Toshiaki Seko, Hiroshi Akasaka, Masayuki Koyama, Nobuaki Himuro, Shigeyuki Saitoh, Shunichi Ogawa, Sayo Miura, Mitsuru Mori, Hirofumi Ohnishi

    Geriatrics (Basel, Switzerland)   9 ( 1 )   2024年1月

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    記述言語：英語   掲載種別：研究論文（学術雑誌）  

    Sarcopenia is the core factor of frailty. This study specifically focused on lower limb muscle strength and examined muscle indices that indicate the risk of frailty or pre-frailty in older adults. The study included 327 community-dwelling individuals aged ≥65 years (43.7% male) who participated in the cohort. Frailty was defined based on five symptoms: weight loss, low activity level, exhaustion, weakness and slowness. Participants were classified into frail (three or more applicable), pre-frail (one to two applicable) and non-frail groups. Muscle strength (knee extension strength, toe grip strength and hand grip strength) were assessed, and appendicular muscle mass was assessed via a bioelectrical impedance analysis. The adjusted odds ratio (OR) of muscle indices for with frailty (frail group vs. pre-frail group) or pre-frailty (pre-frail group vs. non-frail group) were calculated. The prevalence of frail and pre-frail was 7% and 40%, respectively. Adjusted for age, sex, albumin and medical history, knee extension strength was significantly associated with frailty (odds ratio 0.95, 95% CI 0.92-0.98), while hand grip strength was associated with pre-frailty (odds ratio 0.92, 95% CI 0.88-0.97) but not with other muscle indices. This study is significant for identifying knee extension strength as a factor relevant to frailty in older adults considered pre-frailty, emphasizing the importance of this specific muscle measure in predicting and managing frailty.

    DOI： 10.3390/geriatrics9010009

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  • Reliability and validity of the Japanese version of the Visual Function Classification System for children with cerebral palsy. 査読 国際誌

    Hisato Nishibu, Yousuke Ikeda, Takahito Inoue, Nobuaki Himuro

    Child: care, health and development   2023年9月

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    担当区分：最終著者,　責任著者   記述言語：英語   掲載種別：研究論文（学術雑誌）  

    BACKGROUND: Children with cerebral palsy (CP) often experience visual dysfunction that affects motor function and activities of daily living, but no 'gold standard' classification of visual function has been established. In recent years, however, a valid and reliable Visual Function Classification System (VFCS) for children with CP has been developed. AIMS: To examine the reliability and validity of the Japanese version of the VFCS in individuals with CP. METHODS: The translation of the VFCS was performed according to international standards for the translation of measurements. We conducted questionnaires of professionals (three physicians, eight physical therapists, five occupational therapists, six speech-language-hearing therapists and a certified orthoptist) regarding the content validity of the Japanese version of the VFCS. For reliability and concurrent validity, 148 individuals with CP were classified twice by professionals using the Japanese version of the VFCS, Gross Motor Function Classification System (GMFCS), Manual Ability Classification System (MACS), Communication Function Classification System (CFCS) and Eating and Drinking Ability Classification System (EDACS), with several weeks between each evaluation. RESULTS: The content validity of the Japanese version of the VFCS almost met the criteria set. The percentage of positive and neutral opinions given by the professionals with regard to the four items ranged from 74% to 92%. The intra-rater reliability was 0.86 (95% CI 0.75-0.96) by Cohen's kappa and 0.93 (95% CI 0.88-0.96) by intraclass correlation coefficient. The inter-rater reliability was 0.67 (95% CI 0.56-0.78) by Cohen's kappa and 0.79 (95% CI 0.69-0.86) by intraclass correlation coefficient. The Spearman correlation coefficients between the VFCS and the GMFCS, MACS, CFCS and EDACS were 0.783, 0.764, 0.738, 0.738 and 0.830, respectively. The concurrent validity was confirmed by the correlations observed with other classification systems. CONCLUSIONS: The results indicated good reliability and validity for the Japanese version of the VFCS.

    DOI： 10.1111/cch.13175

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  • 小児リハビリテーション分野の目標設定における共同意思決定の現状と目標設定の課題 ─アンケートによる質的研究─ 査読

    楠本 泰士, 樋室 伸顕, 西部 寿人, 木元 稔, 宮本 清隆, 高木 健志, 髙橋 恵里, 阿部 広和

    小児理学療法学   1 ( 1 )   7 - 17   2023年3月

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  • Characterization of prehospital time delay in primary percutaneous coronary intervention for acute myocardial infarction: analysis of geographical infrastructure-dependent and -independent components. 査読 国際誌

    Keisuke Oyatani, Masayuki Koyama, Nobuaki Himuro, Tetsuji Miura, Hirofumi Ohnishi

    International journal of health geographics   22 ( 1 )   7 - 7   2023年3月

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    記述言語：英語   掲載種別：研究論文（学術雑誌）  

    BACKGROUND: Prehospital delay in reaching a percutaneous coronary intervention (PCI) facility is a major problem preventing early coronary reperfusion in patients with ST-elevation myocardial infarction (STEMI). The aim of this study was to identify modifiable factors that contribute to the interval from symptom onset to arrival at a PCI-capable center with a focus on geographical infrastructure-dependent and -independent factors. METHODS: We analyzed data from 603 STEMI patients who received primary PCI within 12 h of symptom onset in the Hokkaido Acute Coronary Care Survey. We defined onset-to-door time (ODT) as the interval from the onset of symptoms to arrival at the PCI facility and we defined door-to-balloon time (DBT) as the interval from arrival at the PCI facility to PCI. We analyzed the characteristics and factors of each time interval by type of transportation to PCI facilities. In addition, we used geographical information system software to calculate the minimum prehospital system time (min-PST), which represents the time required to reach a PCI facility based on geographical factors. We then subtracted min-PST from ODT to find the estimated delay-in-arrival-to-door (eDAD), which represents the time required to reach a PCI facility independent of geographical factors. We investigated the factors related to the prolongation of eDAD. RESULTS: DBT (median [IQR]: 63 [44, 90] min) was shorter than ODT (median [IQR]: 104 [56, 204] min) regardless of the type of transportation. However, ODT was more than 120 min in 44% of the patients. The min-PST (median [IQR]: 3.7 [2.2, 12.0] min) varied widely among patients, with a maximum of 156 min. Prolongation of eDAD (median [IQR]: 89.1 [49, 180] min) was associated with older age, absence of a witness, onset at night, no emergency medical services (EMS) call, and transfer via a non-PCI facility. If eDAD was zero, ODT was projected to be less than 120 min in more than 90% of the patients. CONCLUSIONS: The contribution of geographical infrastructure-dependent time in prehospital delay was substantially smaller than that of geographical infrastructure-independent time. Intervention to shorten eDAD by focusing on factors such as older age, absence of a witness, onset at night, no EMS call, and transfer via a non-PCI facility appears to be an important strategy for reducing ODT in STEMI patients. Additionally, eDAD may be useful for evaluating the quality of STEMI patient transport in areas with different geographical conditions.

    DOI： 10.1186/s12942-023-00328-5

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  • Prehospital emergency care patient satisfaction scale [PECPSS] for care provided by emergency medical teams: Scale development and validation. 査読 国際誌

    Junpei Haruna, Nobuyasu Hayasaka, Yukiko Taguchi, Saori Muranaka, Sachi Niiyama, Hirotoshi Inamura, Shuji Uemura, Keigo Sawamoto, Hirotoshi Mizuno, Nobuaki Himuro, Eichi Narimatsu

    AIMS public health   10 ( 1 )   129 - 144   2023年

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    記述言語：英語   掲載種別：研究論文（学術雑誌）  

    The purpose of this study was to develop and validate an emergency medical technician (EMT) care patient satisfaction scale to measure patient satisfaction with prehospital emergency care. To date, patient satisfaction surveys of EMTs have been performed subjectively, e using each facility's questionnaire, without the use of a validated patient satisfaction scale. However, no specific scale has been devised to assess patient satisfaction with EMTs. The study population comprised patients who used an ambulance between November 2020 and May 2021 (N = 202). A survey instrument was administered to participants who provided informed consent. In the process of validating the patient satisfaction scale, an exploratory factor analysis (EFA) of construct validity was performed. The results of the EFA showed a factor structure consisting of five factors: "teamwork", "explanation and communication", "physical treatment and psychological support", "quickness of transport", and "environment in the ambulance". In addition, domain and summary scores showed good internal reliability (Cronbach's range = 0.82-0.94). The patient satisfaction scale developed in this study was designed and validated considering the role of EMTs and patients' needs for prehospital care. This scale may be useful in the development of assessments and interventions to improve patient satisfaction with EMTs.

    DOI： 10.3934/publichealth.2023011

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  • Preserved Lower Limb Muscle Mass Prevents Insulin Resistance Development in Nondiabetic Older Adults. 査読 国際誌

    Toshiaki Seko, Hiroshi Akasaka, Masayuki Koyama, Nobuaki Himuro, Shigeyuki Saitoh, Tetsuji Miura, Mitsuru Mori, Hirofumi Ohnishi

    Journal of the American Medical Directors Association   24 ( 3 )   376 - 381   2022年12月

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    記述言語：英語   掲載種別：研究論文（学術雑誌）  

    OBJECTIVE: To investigate roles of sarcopenia indexes in prediction of development of insulin resistance in nondiabetic older adults. DESIGN: A 2-year follow-up cohort. SETTING AND PARTICIPANTS: The Tanno-Sobetsu study, a prospective observational cohort, included 194 community-dwelling nondiabetic older adults during 2017-2019. METHODS: Lower limb, upper limb, appendicular, and trunk muscle masses by a bioelectrical impedance analysis, grip strength, knee extension torque, and walking speed were measured in study participants aged ≥65 years (79 men and 115 women) at baseline. Muscle mass and strength were divided by the weight, and then multiplied by 100 to calculate the weight ratio (%). Insulin resistance was assessed by homeostasis model (HOMA-IR) at baseline, and the study participants whose HOMA-IR was less than 1.73 at baseline were followed for a maximum of 2 years. The study endpoint was development of insulin resistance defined as HOMA-IR ≥1.73. The adjusted hazard ratio (HR) of each sarcopenia component for development of insulin resistance was calculated. RESULTS: Lower limb muscle mass (HR 0.88, 95% CI 0.79-0.98) and appendicular muscle mass (HR 0.89, 95% CI 0.81-0.99), but not other sarcopenia components, were associated with the development of insulin resistance, independently of sex and age, HOMA-IR, and waist circumference at baseline. CONCLUSIONS AND IMPLICATIONS: The loss of lower limb muscle mass is a significant risk factor for development of insulin resistance independently of obesity in nondiabetic older adults. The lower limb muscle mass may be a novel target of interventions for the prevention of diabetes in older adults.

    DOI： 10.1016/j.jamda.2022.12.002

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  • Walking Speed Is Better Than Hand Grip Strength as an Indicator of Early Decline in Physical Function with Age in Japanese Women Over 65: A Longitudinal Analysis of the Tanno-Sobetsu Study Using Linear Mixed-Effects Models. 査読 国際誌

    Shunichi Ogawa, Nobuaki Himuro, Masayuki Koyama, Toshiaki Seko, Mitsuru Mori, Hirofumi Ohnishi

    International journal of environmental research and public health   19 ( 23 )   2022年11月

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    記述言語：英語   掲載種別：研究論文（学術雑誌）  

    The decline in physical function with age is a major contributor to the need for long-term care. Age-related changes in hand grip strength, knee extension, and walking speed have been reported in cross-sectional studies, but longitudinal data are needed. This longitudinal study measured changes in these three measures among community-dwelling adults aged 65-89 years who participated in general health examinations between 2017 and 2019. Analyses were stratified by sex. Linear mixed-effects models adjusted for confounding factors were used to examine the interaction of different patterns of change with age of the three measures. A total of 284 participants were included in the analysis. The interaction term of age × walking speed, with age × handgrip strength as the reference, was statistically significant in women and showed different patterns in walking speed and hand grip strength. In men, none of the age × physical function interaction terms were significant in any model. For early recognition of the onset of physical function decline in older adults, any of the three measures may be used in men, but walking speed may be more suitable than hand grip strength in women. These findings may be useful in devising sex-specific screening strategies.

    DOI： 10.3390/ijerph192315769

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  • Psychometric evaluation and distribution of classification systems in children with cerebral palsy in Japan. 査読 国際誌

    Hisato Nishibu, Tsugumi Hosokawa Seino, Nobuaki Himuro

    Journal of pediatric rehabilitation medicine   2022年11月

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    担当区分：最終著者,　責任著者   記述言語：英語   掲載種別：研究論文（学術雑誌）  

    PURPOSE: The study sought to examine the content validity, the intra- and inter-rater reliability, and concurrent validity of the Japanese versions of the Manual Ability Classification System, the Communication Function Classification System, and the Eating and Drinking Ability Classification System, and representation of the distribution of the levels of each classification systems in comparison to the Gross Motor Function Classification System levels for children with cerebral palsy. METHODS: The Japanese versions were developed using the back-translation method. For content validity, professionals were asked to complete a questionnaire including items on the appropriateness of the translation, its validity, and distinctions among levels. For reliability, professionals used the three classification systems twice in children with cerebral palsy. For concurrent validity, relationships among the four classification systems were examined by correlation analyses. RESULTS: Participants included twenty-one professionals and 290 children with cerebral palsy (mean age: 12 years two months, female: 132, male: 158). The content validity was generally good. For reliability, the lower limit of the 95% confidence interval for the intraclass correlation coefficients was greater than 0.89, and the correlation coefficients were high. CONCLUSION: The results of this study showed good reliability and validity of the functional classification systems in Japan.

    DOI： 10.3233/PRM-210098

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  • Efficacy of Knee-Ankle-Foot Orthosis on Functional Mobility and Activities of Daily Living in Patients with Stroke: A Systematic Review of Case Reports. 査読 国際誌

    Eiji Kobayashi, Kenta Hiratsuka, Hirokazu Haruna, Nobue Kojima, Nobuaki Himuro

    Journal of rehabilitation medicine   54   jrm00290   2022年7月

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    担当区分：最終著者   記述言語：英語   掲載種別：研究論文（学術雑誌）  

    OBJECTIVE:  To synthesize available evidence from case reports regarding the efficacy of knee-ankle-foot orthosis (KAFO) on functional mobility and activities of daily living (ADL) in patients with stroke. METHODS:  The following databases were searched, based on the Population Intervention Comparison Outcome (PICO) model: PubMed, CINAHL, Sco- pus, Cochrane Central Register of Controlled Trials, PEDro, Web of Science, and Igaku Chuo Zassi (in Japanese). Methodological quality was assessed using the CARE checklist. RESULTS:  A total of 14 articles, including 15 cases, were selected. Clinically meaningful improvement in functional mobility was reported in 10 of 15 cases, measured using the Functional Ambulatory Category, Trunk Control Test, walking speed, and Berg Balance Scale. Clinically meaningful improvement in ADL was reported in 9 of 15 cases, measured using the Barthel Index and Functional Independent Measure. However, the methodological quality of the reviewed articles was low, with missing information on limitations of management, adverse events, and patient-reported outcomes. CONCLUSION:  This systematic review of case reports found a low level of evidence of the efficacy of KAFO in terms of improvement in functional mobility and ADL. Of value, this study revealed the optimal outcomes for measuring the efficacy of KAFO.

    DOI： 10.2340/jrm.v54.87

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  • Intra-rater and inter-rater reliability, minimal detectable change, and construct validity of the Edinburgh Visual Gait Score in children with cerebral palsy. 査読 国際誌

    Hirokazu Abe, Shotaro Koyanagi, Yasuaki Kusumoto, Nobuaki Himuro

    Gait & posture   94   119 - 123   2022年3月

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    担当区分：最終著者   記述言語：英語   掲載種別：研究論文（学術雑誌）  

    BACKGROUND: The Edinburgh Visual Gait Score (EVGS) has been used for observational gait assessment in children with cerebral palsy (CP). However, the measurement error of the EVGS and its detailed relationship with gross motor function remain unclear. RESEARCH QUESTIONS: This study aimed to confirm the intra-rater and inter-rater reliability as well as the minimal detectable change (MDC) values for the EVGS with the use of the video analysis software and examine the relationship between the EVGS and the Gross Motor Function Measure 66 (GMFM-66) with regard to construct validity. METHODS: This cross-sectional study was conducted for 62 children (mean age 11.3 ± 3.9 years) with spastic CP at Gross Motor Function Classification System (GMFCS) level I (32 children), II (25 children) or III (5 children). Three raters independently scored the EVGS using Kinovea video analysis software. The intra-rater and inter-rater reliability were calculated using intra-class correlation coefficients (ICC2,1), and the MDC90 was calculated using standard error of measurement. The construct validity was examined by correlating the EVGS with the GMFM-66. RESULTS: The EVGS showed good or excellent reliability within each rater (ICC2,1 = 0.90-0.97) and between raters (ICC2,1 = 0.91). The MDC90 of the EVGS ranged from 3.6 to 6.0. There was a significant correlation between the EVGS and the GMFM-66 (r = - 0.69 to - 0.73, p < 0.001). SIGNIFICANCE: The intra-rater and inter-rater reliability of the EVGS is sufficient for observational gait assessment. The high correlation between the EVGS and the GMFM-66 supports its construct validity. The authors propose an MDC of 6.0 for the EVGS. These results can help in the application of EVGS to children with CP at GMFCS level I-II with mild to moderate gait pathology, as there were few children with CP at GMFCS level III.

    DOI： 10.1016/j.gaitpost.2022.03.004

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  • Feasibility and informativeness of the Canadian occupational performance measure for identifying priorities in patients with Parkinson's disease. 査読 国際誌

    Eiji Kobayashi, Nobuaki Himuro, Yuji Mitani, Takuya Tsunashima, Kyouhei Nomura, Susumu Chiba

    Physiotherapy theory and practice   1 - 8   2022年1月

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    記述言語：英語   掲載種別：研究論文（学術雑誌）  

    OBJECTIVE: The aim of this study was to examine the feasibility and informativeness of the Canadian Occupational Performance Measure (COPM) for identifying the priorities of patients with Parkinson's disease (PD). METHODS: The COPM was administered in patients with PD who were admitted to the hospital. Feasibility was investigated by confirming the acceptability and practicality of the COPM interview. To investigate informativeness, identified priorities were classified according to the International Classification of Functioning, Disability and Health (ICF) and were cross-referenced with data from similar studies using the Patient-Specific Functional Scale (PSFS) and the Patient-Specific Index for PD (PSI-PD). RESULTS: All 61 patients who participated in this study completed the COPM, and a total of 197 priorities were identified. The most frequently identified priorities were "Recreation and leisure," "Preparing meals," "Walking," "Doing housework," and "Caring for household objects." The priorities identified using the PSFS and the PSI-PD were less diverse and focused on "Mobility" or "Self-care." CONCLUSIONS: The COPM is a feasible and informative tool for identifying priorities in patients with PD. Its informativeness was demonstrated by its ability to identify diverse priorities across the ICF domains of "Activity and participation" that had not been identified in the studies using the PSFS and PSI-PD.

    DOI： 10.1080/09593985.2021.2023926

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  • Mindfulness intervention improves cognitive function in older adults by enhancing the level of miRNA-29c in neuron-derived extracellular vesicles. 査読 国際誌

    Shin Hashizume, Masako Nakano, Kenta Kubota, Seiichi Sato, Nobuaki Himuro, Eiji Kobayashi, Akinori Takaoka, Mineko Fujimiya

    Scientific reports   11 ( 1 )   21848 - 21848   2021年11月

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    記述言語：英語   掲載種別：研究論文（学術雑誌）  

    Although mindfulness-based stress reduction (MBSR) improves cognitive function, the mechanism is not clear. In this study, people aged 65 years and older were recruited from elderly communities in Chitose City, Japan, and assigned to a non-MBSR group or a MBSR group. Before and after the intervention, the Japanese version of the Montreal Cognitive Assessment (MoCA-J) was administered, and blood samples were collected. Then, neuron-derived extracellular vesicles (NDEVs) were isolated from blood samples, and microRNAs, as well as the target mRNAs, were evaluated in NDEVs. A linear mixed model analysis showed significant effects of the MBSR x time interaction on the MoCA-J scores, the expression of miRNA(miR)-29c, DNA methyltransferase 3 alpha (DNMT3A), and DNMT3B in NDEVs. These results indicate that MBSR can improve cognitive function by increasing the expression of miR-29c and decreasing the expression of DNMT3A, as well as DNMT3B, in neurons. It was also found that intracerebroventricular injection of miR-29c mimic into 5xFAD mice prevented cognitive decline, as well as neuronal loss in the subiculum area, by down-regulating Dnmt3a  and Dnmt3b  in the hippocampus. The present study suggests that MBSR can prevent neuronal loss and cognitive impairment by increasing the neuronal expression of miR-29c.

    DOI： 10.1038/s41598-021-01318-y

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  • Reliability, validity, and minimal clinically important differences of the Japanese version of the early clinical assessment of balance in children with cerebral palsy. 査読 国際誌

    Takahito Inoue, Hiroto Izumi, Hisato Nishibu, Nobuaki Himuro

    Disability and rehabilitation   1 - 7   2021年9月

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    担当区分：最終著者   記述言語：英語   掲載種別：研究論文（学術雑誌）  

    PURPOSE: We aimed to translate the Early Clinical Assessment of Balance (ECAB) from English to Japanese and examine the content validity, inter-rater reliability, intra-rater reliability, construct validity, and minimal clinically important difference (MCID) for children with cerebral palsy (CP). METHODS: The ECAB was translated into Japanese per international standards. The study included 106 children with CP and, aged 1.5-12 years. The ECAB, the Gross Motor Function Classification System (GMFCS), and the Gross Motor Function Measure 66 Basal & Ceiling (GMFM-66-B&C) were measured. The content and construct validity were examined based on therapist feedback and correlations between the ECAB and GMFM-66-B&C. The inter-rater reliability and the intra-rater reliability were examined by the intra-class correlation coefficient (ICC). The MCID was calculated by the anchor-based method with the GMFM-66-B&C. RESULTS: High content validity (more than 80% agreement), inter-rater and intra-rater reliability (ICC = 0.99 & 0.99, respectively), and construct validity (r = 0.96) were demonstrated, with MCID values of 7.39, 5.32, and 6.88 observed for the GMFCS I/II, III, and IV/V, respectively. CONCLUSION: The Japanese version of the ECAB is a reliable and valid measure of balance ability in children with CP. Furthermore, the MCID of the ECAB was established, appears to be useful in helping to provide rehabilitation.Implications for RehabilitationThe Japanese version of the Early Clinical Assessment of Balance is easy, safe, and low-cost, and has high reliability and validity for assessing balance ability in children with cerebral palsy.The use of the Japanese version of the Early Clinical Assessment of Balance is beneficial for determining the therapeutic effect, appropriate treatment, and prediction of prognosis regarding balance ability in children with cerebral palsy.The minimal detectable change of the Japanese version of the ECAB suggest that a score exceeding 6 is a true change and the minimal clinically important difference of the Japanese version of the ECAB suggest that the scores exceeding 8, 6, and 7 for the GMFCS I/II, III, and IV/V, respectively, is a clinically useful change.

    DOI： 10.1080/09638288.2021.1977859

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  • Gait profile score and gait variable scores in spina bifida. 査読 国際誌

    Hiroyori Fusagawa, Hiroki Fujita, Toshikatsu Matsuyama, Nobuaki Himuro, Atsushi Teramoto, Toshihiko Yamashita, Paulo Selber

    Journal of pediatric orthopedics. Part B   2021年5月

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    記述言語：英語   掲載種別：研究論文（学術雑誌）  

    OBJECTIVE: Quantitative data assessment on the basis of three-dimensional gait analysis has been routinely used in the evaluation of pathological gait of children with cerebral palsy. However, a similar quantitative methodology has not been applied for spina bifida patients in whom atypical gait patterns are thought to correlate with various levels of neurological paralysis. To investigate the differences among gait patterns in spina bifida between different levels of neurological lesions using quantitative methods: Gait profile score (GPS) and gait variable scores (GVS), scoring subject's gait deviation from a reference. METHODS: In this cross-sectional study, 22 children with spina bifida (11 women, 11 men; mean age 9.4 years, SD 3.8 years, range 3-17 years), were examined using three-dimensional gait analysis from 2008 to 2018. Physical examination allowed for classification of each of the 44 limbs as either L4, L5 or S1 and comparison with the GPS and GVS using a linear mixed model. RESULTS: GPS and the GVS of the pelvis and hip range of motion in the coronal plane were significantly higher in the L4 group than in the L5 and S1 groups (GPS, P = 0.041, P = 0.003, respectively; GVS of pelvis, P = 0.001, P = 0.001; GVS of hip, P < 0.001, P < 0.001) GVS (foot progression angle) was significantly lower in the S1 group than in L4 and L5 groups (P < 0.001, P = 0.037). CONCLUSIONS: We found that GPS and GVS enable us to quantitatively assess the differences among gait patterns between different neurological levels. The scoring tool showed the potential for detecting individual neurological changes.

    DOI： 10.1097/BPB.0000000000000877

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  • Individualized nutritional treatment for acute stroke patients with malnutrition risk improves functional independence measurement: A randomized controlled trial. 査読

    Ikuto Otsuki, Nobuaki Himuro, Hiroomi Tatsumi, Mitsuru Mori, Yoshimasa Niiya, Yukihiro Kumeta, Michiaki Yamakage

    Geriatrics & gerontology international   20 ( 3 )   176 - 182   2020年3月

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    記述言語：英語   掲載種別：研究論文（学術雑誌）  

    AIM: The aim of the present study was to investigate the effects of individualized nutritional treatment on the activities of daily living of acute stroke patients. METHODS: This was a randomized controlled study. The eligibility criteria were acute stroke, age >65 years and the presence of malnutrition risk. Between September 2016 and December 2017, 128 patients were assigned to either the standard or intensive group (individualized nutritional treatment). The intensive group received energy that was calculated using the Harris-Benedict equation. The main outcome measures were the total functional independence measurement gain from the time of assignment to the time of discharge from the recovery hospital or at 3 months after the stroke onset, and motor and cognitive functional independence measurement gains. RESULTS: Compared with the standard group, the intensive group had significantly higher median energy intake (P < 0.001); significantly greater functional independence measurement gains in the total score (42 vs. 22; P = 0.02) and motor subscore (P = 0.01), but similar cognitive subscore. CONCLUSION: Individualized nutritional treatment improved the activities of daily living of older acute stroke patients with malnutrition risk. Geriatr Gerontol Int 2019; ••: ••-••.

    DOI： 10.1111/ggi.13854

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  • Lower limb muscle mass is associated with insulin resistance more than lower limb muscle strength in non-diabetic older adults. 査読

    Toshiaki Seko, Hiroshi Akasaka, Masayuki Koyama, Nobuaki Himuro, Shigeyuki Saitoh, Tetsuji Miura, Mitsuru Mori, Hirofumi Ohnishi

    Geriatrics & gerontology international   19 ( 12 )   1254 - 1259   2019年12月

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    記述言語：英語   掲載種別：研究論文（学術雑誌）  

    AIM: We examined the association of muscle mass and muscle strength with insulin resistance, focusing on lower limb muscles. METHODS: This was a cross-sectional study, and participants were registered in 2017 from the Tanno-Sobetsu Study, a population-based cohort study. After excluding individuals aged <64 years or with a history of diabetes mellitus, 272 non-diabetic older adults (116 men, 156 women) met the inclusion criteria. According to the homeostasis model assessment of insulin resistance, the participants were divided into two groups; that is, the insulin resistance group (homeostasis model assessment of insulin resistance ≥1.73) and non-insulin resistance group (homeostasis model assessment of insulin resistance <1.73). Muscle mass (lower limb, upper limb, appendicular and trunk) and muscle strength (grip strength and knee extension torque) were measured and divided by the weight, and then multiplied by 100 to calculate the weight ratio (%). The adjusted odds ratio (OR) of each muscle index for risk of insulin resistance was calculated separately for both men and women. RESULTS: Lower limb muscle mass (OR 0.72, 95% CI 0.55-0.92 in men; OR 0.69, 95% CI 0.51-0.96 in women, respectively) and appendicular muscle mass (OR 0.75, 95% CI 0.61-0.94 in men; OR 0.72, 95% CI 0.54-0.95 in women, respectively), but not other muscle indexes, were associated with risk of insulin resistance, after adjusting for age, body mass index, highly sensitive C-reacting protein and smoking habits. CONCLUSIONS: Lower limb muscle mass of non-diabetic older adults is independently related to insulin resistance. Geriatr Gerontol Int 2019; 19: 1254-1259.

    DOI： 10.1111/ggi.13805

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  • The effects of renin–angiotensin system inhibitors on mortality, cardiovascular events, and renal events in hypertensive patients with diabetes: a systematic review and meta-analysis of randomized controlled trials 査読 国際誌

    Kunimura A, Himuro N, Fujiyoshi A, Segawa H, Ohnishi H, Saitoh S

    Hypertension Research   42 ( 5 )   669 - 680   2019年5月

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    記述言語：英語   掲載種別：研究論文（学術雑誌）  

    DOI： 10.1038/s41440-019-0234-6

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  • The Impact of Air Transport for Acute Coronary Syndrome Patients. 査読 国際誌

    Homma H, Niiyama Y, Sonoda H, Himuro N, Yamakage M

    Air Medical Journal   38 ( 2 )   73 - 77   2019年3月

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    記述言語：英語   掲載種別：研究論文（学術雑誌）  

    DOI： 10.1016/j.amj.2018.11.008

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  • Cross-Cultural Validation Study of the Japanese Version of the ABILOCO-Kids in Ambulatory Children With Cerebral Palsy Using Rasch Analysis. 査読 国際誌

    Nobuaki Himuro, Hisato Nishibu, Hirokazu Abe, Mitsuru Mori

    Physical & occupational therapy in pediatrics   39 ( 6 )   679 - 691   2019年

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    担当区分：筆頭著者,　責任著者   記述言語：英語   掲載種別：研究論文（学術雑誌）  

    Aims: To determine the structural validity, construct validity, cross-cultural validity, internal consistency and test-retest reliability of the Japanese version of the ABILOCO-Kids in children with cerebral palsy. Methods: One-hundred sixteen parents of children with cerebral palsy (Gross Motor Function Classification System level I [n = 66], II [n = 32], and III [n = 18]) reported on walking ability using the Japanese version of the ABILOCO-Kids. For test-retest reliability, 23 participants were evaluated. Results: The mean ABILOCO-Kids logit score was 2.48 (range -7.44 to 5.83). Rasch analysis and principal component analysis were used to determine the structural validity. The construct validity was confirmed on the basis of differences in the ABILOCO-Kids scores among the Gross Motor Function Classification System levels. Cronbach's α and the item-to-total correlation coefficient supported the internal consistency. The intra-class correlation coefficient was 0.96, standard error of measurement 0.56 and minimal detectable change 1.55. The cross-cultural validity analyses showed differential item functioning according to the analyses of the invariance of item difficulty and person's ability estimates. Conclusions: The ABILOCO-Kids is a reliable and valid measure of walking ability in children with cerebral palsy in Japan. The lack of evidence on cross-cultural validity indicates we should interpret results cautiously in cases of international comparison.

    DOI： 10.1080/01942638.2019.1609150

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  • Reliability and Validity of Hip Extensor Strength Measurement in Sitting Position by a Handheld Dynamometer in the Older Adults. 査読

    Seko T, Mori M, Ohnishi H, Himuro N, Takahashi Y, Kumamoto T, Ito T

    Journal of Geriatric Physical Therapy   42 ( 4 )   E39 - E44   2018年8月

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    掲載種別：研究論文（学術雑誌）  

    DOI： 10.1519/JPT.0000000000000207

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  • Activated forms of astrocytes with higher GLT-1 expression are associated with cognitive normal subjects with Alzheimer pathology in human brain. 査読 国際誌

    Eiji Kobayashi, Masako Nakano, Kenta Kubota, Nobuaki Himuro, Shougo Mizoguchi, Takako Chikenji, Miho Otani, Yuka Mizue, Kanna Nagaishi, Mineko Fujimiya

    Scientific reports   8 ( 1 )   1712 - 1712   2018年1月

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    記述言語：英語   掲載種別：研究論文（学術雑誌）  

    Although the cognitive impairment in Alzheimer's disease (AD) is believed to be caused by amyloid-β (Aβ) plaques and neurofibrillary tangles (NFTs), several postmortem studies have reported cognitive normal subjects with AD brain pathology. As the mechanism underlying these discrepancies has not been clarified, we focused the neuroprotective role of astrocytes. After examining 47 donated brains, we classified brains into 3 groups, no AD pathology with no dementia (N-N), AD pathology with no dementia (AD-N), and AD pathology with dementia (AD-D), which represented 41%, 21%, and 38% of brains, respectively. No differences were found in the accumulation of Aβ plaques or NFTs in the entorhinal cortex (EC) between AD-N and AD-D. Number of neurons and synaptic density were increased in AD-N compared to those in AD-D. The astrocytes in AD-N possessed longer or thicker processes, while those in AD-D possessed shorter or thinner processes in layer I/II of the EC. Astrocytes in all layers of the EC in AD-N showed enhanced GLT-1 expression in comparison to those in AD-D. Therefore these activated forms of astrocytes with increased GLT-1 expression may exert beneficial roles in preserving cognitive function, even in the presence of Aβ and NFTs.

    DOI： 10.1038/s41598-018-19442-7

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  • Change in mobility function and its causes in adults with cerebral palsy by Gross Motor Function Classification System level: A cross-sectional questionnaire study. 査読 国際誌

    Nobuaki Himuro, Reiko Mishima, Takashi Seshimo, Toshibumi Morishima, Keisuke Kosaki, Shigeharu Ibe, Yoshimi Asagai, Koji Minematsu, Kazuhiro Kurita, Tsutomu Okayasu, Tsukasa Shimura, Kotaro Hoshino, Toshiro Suzuki, Taiichiro Yanagizono

    NeuroRehabilitation   42 ( 4 )   383 - 390   2018年

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    担当区分：筆頭著者,　責任著者   記述言語：英語   掲載種別：研究論文（学術雑誌）  

    BACKGROUND: The prognosis for mobility function by Gross Motor Function Classification System (GMFCS) level is vital as a guide to rehabilitation for people with cerebral palsy. OBJECTIVE: This study sought to investigate change in mobility function and its causes in adults with cerebral palsy by GMFCS level. METHODS: We conducted a cross-sectional questionnaire study. RESULTS: A total of 386 participants (26 y 8 m, SD 5 y 10 m) with cerebral palsy were analyzed. Participant numbers by GMFCS level were: I (53), II (139), III (74) and IV (120). The median age of participants with peak mobility function in GMFCS level III was younger than that in the other levels. 48% had experienced a decline in mobility. A Kaplan-Meier plot showed the risk of mobility decline increased in GMFCS level III; the hazard ratio was 1.97 (95% CI, 1.20-3.23) compared with level I. The frequently reported causes of mobility decline were changes in environment, and illness and injury in GMFCS level III, stiffness and deformity in level IV, and reduced physical activity in level II and III. CONCLUSIONS: Peak mobility function and mobility decline occurred at a younger age in GMFCS level III, with the cause of mobility decline differing by GMFCS level.

    DOI： 10.3233/NRE-172340

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  • The criterion validity and intra-rater reliability of the Japanese version of the Functional Mobility Scale in children with cerebral palsy. 査読 国際誌

    Nobuaki Himuro, Hisato Nishibu, Hirokazu Abe, Mitsuru Mori

    Research in developmental disabilities   68   20 - 26   2017年9月

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    担当区分：筆頭著者,　責任著者   記述言語：英語   掲載種別：研究論文（学術雑誌）  

    DOI： 10.1016/j.ridd.2017.07.004

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  • Family-centered care for preterm infants: Parent and physical therapist perceptions. 査読 国際誌

    Saori Miyagishima, Nobuaki Himuro, Naoki Kozuka, Mitsuru Mori, Hiroyuki Tsutsumi

    Pediatrics international : official journal of the Japan Pediatric Society   59 ( 6 )   698 - 703   2017年6月

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    記述言語：英語   掲載種別：研究論文（学術雑誌）  

    DOI： 10.1111/ped.13266

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  • Easy-to-use clinical measures of walking ability in children and adolescents with cerebral palsy: a systematic review. 査読 国際誌

    Nobuaki Himuro, Hirokazu Abe, Hisato Nishibu, Tsugumi Seino, Mitsuru Mori

    Disability and rehabilitation   39 ( 10 )   957 - 968   2017年5月

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    担当区分：筆頭著者,　責任著者   記述言語：英語   掲載種別：研究論文（学術雑誌）  

    DOI： 10.1080/09638288.2016.1175036

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  • Clinical utility of the 6-min walk test for patients with moderate Parkinson's disease. 査読 国際誌

    Eiji Kobayashi, Nobuaki Himuro, Mitsuhiko Takahashi

    International journal of rehabilitation research. Internationale Zeitschrift fur Rehabilitationsforschung. Revue internationale de recherches de readaptation   40 ( 1 )   66 - 70   2017年3月

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    記述言語：英語   掲載種別：研究論文（学術雑誌）  

    DOI： 10.1097/MRR.0000000000000205

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  • BAK is a predictive and prognostic biomarker for the therapeutic effect of docetaxel treatment in patients with advanced gastric cancer. 査読

    Tomohiro Kubo, Yutaka Kawano, Nobuaki Himuro, Shintaro Sugita, Yasushi Sato, Kazuma Ishikawa, Kohichi Takada, Kazuyuki Murase, Koji Miyanishi, Tsutomu Sato, Rishu Takimoto, Masayoshi Kobune, Takayuki Nobuoka, Koichi Hirata, Tetsuji Takayama, Mitsuru Mori, Tadashi Hasegawa, Junji Kato

    Gastric cancer : official journal of the International Gastric Cancer Association and the Japanese Gastric Cancer Association   19 ( 3 )   827 - 38   2016年7月

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    記述言語：英語   掲載種別：研究論文（学術雑誌）  

    DOI： 10.1007/s10120-015-0557-1

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  • Measurement of family-centered care in the neonatal intensive care unit and professional background. 査読 国際誌

    N Himuro, S Miyagishima, N Kozuka, H Tsutsumi, M Mori

    Journal of perinatology : official journal of the California Perinatal Association   35 ( 4 )   284 - 9   2015年4月

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    担当区分：筆頭著者,　責任著者   記述言語：英語   掲載種別：研究論文（学術雑誌）  

    DOI： 10.1038/jp.2014.204

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  • Measurement of family-centred care: translation, adaptation and validation of the Measure of Processes of Care (MPOC-56 and -20) for use in Japan. 査読 国際誌

    N Himuro, N Kozuka, M Mori

    Child: care, health and development   39 ( 3 )   358 - 65   2013年5月

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    担当区分：筆頭著者,　責任著者   記述言語：英語   掲載種別：研究論文（学術雑誌）  

    DOI： 10.1111/j.1365-2214.2012.01371.x

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書籍等出版物

  • 日本語版GMFM-66 & GMFM-88: 脳性麻痺児のための粗大運動評価

    近藤 和泉, 楠本 泰士

    医学書院  2025年8月  （ ISBN:4260060201 ）

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    総ページ数：320  

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  • PT・OTのための子どものリハビリテーション評価マニュアル

    楠本泰士（ 担当： 分担執筆 範囲: 第1章「測定値の読み方と活用」、第5章「医療分野の移動能力測定（FMS）」、「総合的な上肢機能（ABILHAND-Kids）」、第6章「家族を中心としたかかわり（MPOC）」）

    医学書院  2025年4月  （ ISBN:4260057758 ）

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    総ページ数：344  

    ASIN

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  • 人間発達学 (Crosslink basic リハビリテーションテキスト)

    浅野, 大喜（ 担当： 分担執筆 範囲: 第2章各論10「家族関係の発達」）

    メジカルビュー社  2021年11月  （ ISBN:4758320624 ）

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    総ページ数：288   記述言語：日本語  

    CiNii Books

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  • 統合と解釈のための 小児リハ評価ガイド

    楠本, 泰士, 友利, 幸之介（ 担当： 分担執筆 範囲: 第1章「評価尺度の特性 信頼性・妥当性・反応性」, 第2章「MACS 脳性麻痺児の手指操作能力を評価しよう」, 「CFCS 脳性麻痺児・者のコミュニケーション能力を分類しよう」, 「EDACS 脳性麻痺児・者の摂食・嚥下能力を分類しよう」, 「TUG 歩行機能とバランス能力を評価しよう」, 「ABILOCO-Kids 脳性麻痺児の歩行遂行能力を評価しよう」, 「FMS 日常生活の移動能力を評価しよう」, 「MPOC 家族の思いを評価しよう」)）

    メジカルビュー社  2019年9月  （ ISBN:4758319480 ）

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    総ページ数：421   記述言語：日本語  

    CiNii Books

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  • イラストでわかる人間発達学

    上杉 雅之（ 担当： 分担執筆 範囲: 第3章「発達検査」）

    医歯薬出版  2015年9月  （ ISBN:4263219457 ）

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    総ページ数：279   担当ページ：41-60  

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  • いのちはどう生まれ、育つのか――医療、福祉、文化と子ども (岩波ジュニア新書)

    道信 良子（ 担当： 分担執筆 範囲: 「優貴にとって「動く」ということ」）

    岩波書店  2015年3月  （ ISBN:4005007996 ）

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    総ページ数：208   担当ページ：77-88  

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MISC

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受賞

  • 奨励賞

    2024年11月   第11回日本小児理学療法学会学術大会   脳性麻痺以外の診断・疾患におけるGMFMの適用と評価尺度の特性ーシステマティックレビューー

    阿部広和, 東周平, 樋室伸顕

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  • 奨励賞

    2024年11月   第11回日本小児理学療法学会学術大会   脳性麻痺児のリハビリテーションと粗大運動能力の量反応関係：仮想コントロール群を用いたメタアナリシス

    樋室伸顕, 西部寿人, 阿部広和, 東周平, 井上孝仁, 楠本泰士, 小山雅之, 大西浩文

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  • 優秀演題賞

    2024年11月   第11回日本サルコペニア・フレイル学会大会   日本人高齢者において骨格筋量減少は肥満の有無に関わらずインスリン抵抗性進展に寄与する -端野・壮瞥町研究-

    世古俊明, 樋室伸顕, 小山雅之, 小川峻一, 赤坂憲, 森満, 大西浩文

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  • 最優秀賞

    2021年12月   第8回日本小児理学療法学会学術大会   脳性麻痺児における日本語版Edinburgh Visual Gait Score（観察的歩行評価）の信頼性・妥当性

    阿部 広和, 小柳 翔太郎, 楠本 泰士, 樋室 伸顕

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  • 最優秀賞

    2021年11月   第8回日本予防理学療法学会学術大会   非糖尿病高齢者における下肢筋量がインスリン抵抗性進展に及ぼす影響

    世古 俊明, 赤坂 憲, 樋室 伸顕, 小山 雅之, 森 満, 大西 浩文

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  • 最優秀賞

    2018年12月   第5回日本小児理学療法学会学術大会   脳性麻痺児の移動能力は歩行能力評価尺度でどのくらい評価できるのか

    樋室伸顕, 西部寿人

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共同研究・競争的資金等の研究課題

  • 重度脳性麻痺児のリハビリテーションのための評価尺度コアセットの開発

    研究課題/領域番号：25K14432  2025年4月 - 2028年3月

    日本学術振興会  科学研究費助成事業  基盤研究(C)

    樋室 伸顕

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    配分額：4680000円 （ 直接経費：3600000円 、 間接経費：1080000円 ）

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  • 小児理学療法研究を推進するための基盤づくり

    研究課題/領域番号：21K11315  2021年4月 - 2024年3月

    日本学術振興会  科学研究費助成事業 基盤研究(C)  基盤研究(C)

    樋室 伸顕

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    配分額：4290000円 （ 直接経費：3300000円 、 間接経費：990000円 ）

    日本の小児理学療法の研究は、臨床家と研究者の協働による継続した研究活動が少なく、臨床と研究の結びつきが弱い。そのため日本の小児理学療法における学術的な基盤や指針が存在しない。一方で日本には療育という独自の文化があり、臨床では効果をあげている。これを科学的に定義づけることで、臨床と研究が結びついた日本発の小児理学療法研究の発展へとつながるのではないかと考えた。そこで本研究では、臨床家から臨床上の疑問を集め、それを研究疑問へと構造化する。その疑問の解決のために臨床家とともにシステマティックレビューをおこない、成果はオープンアクセス誌で公表する。同時に新たな研究課題を明確にして公開することで、さらなる研究活動の発展へとつなげる。臨床と研究がつながった小児理学療法研究推進のための基盤をつくることが本研究の目的である。
    今年度は、臨床家から募集した臨床上の疑問のうち、4つを研究疑問へと構造化した。そのうち1編は学会発表を終え論文化しており現在投稿準備中である。うち1編はデータベース検索を終え現在1次スクリーニング中、うち1編はPROSPEROへ登録作業中、1編は研究計画書を作成している。

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  • 地域一般住民高齢者における重症化予防・介護予防対象ハイリスク者同定の試み

    研究課題/領域番号：20K10532  2020年4月 - 2023年3月

    日本学術振興会  科学研究費助成事業 基盤研究(C)  基盤研究(C)

    大西 浩文, 小山 雅之, 斉藤 重幸, 樋室 伸顕

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    配分額：4420000円 （ 直接経費：3400000円 、 間接経費：1020000円 ）

    本研究は、我々が継続している地域一般住民コホートにおける高齢者を対象に、高血圧、糖尿病、循環器疾患への罹患とフレイル・サルコペニアの進展の両者に共通する危険因子を明らかにすることを目的としている。令和2年度は平成29年度の受診者で65歳以上の342名を対象とした横断的検討を行い、男女とも下肢筋量体重比(%)とインスリン抵抗性の指標であるHOMA-IRとの間に有意な関連を認めることを確認した。
    今年度は縦断的な検討を行うこととし、平成29年度の健診にて65歳以上でフレイル・サルコペニア関連の検査を受けた者のうち初年度の時点で糖尿病の者を除外し、平成30年、令和元年の健診を3年連続受診した206名を対象として、初年度の下肢筋量体重比(%)の男女別中央値で高群、低群の2群に分け、その後のHOMA-IRの変動について、繰り返し測定二元配置分散分析を行ったところ、年齢とともにHOMA-IRは有意に上昇し、下肢筋量体重比(%)が低い群では高い群と比較してHOMA-IRが高く推移することが示された。また、年次と下肢筋量体重比との間には有意な交互作用は認めなかった。また、平成29年受診者中、糖尿病を除外して、令和元年の健診も受診した241名を対象とし、令和元年度の時点でHOMA-IR≧1.73のインスリン抵抗性進展の有無を従属変数とした多重ロジスティック回帰分析を行うと、年齢、性別、腹部肥満の有無で調整後の下肢筋量体重比低下のオッズ比は2.67（95%CI：1.44-4.95）であり、さらに初年度のHOMA-IRで調整してもオッズ比2.17（95%CI：1.07-11.75）であった。以上の結果より、縦断的な検討において、初年度の下肢筋量体重比の低下は、将来のインスリン抵抗性進展の強いリスク因子である可能性が示唆された。

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  • 脳性麻痺児の移動能力変化に関する臨床応用可能な評価法を用いた縦断的研究

    研究課題/領域番号：17K01460  2017年4月 - 2022年3月

    日本学術振興会  科学研究費助成事業 基盤研究(C)  基盤研究(C)

    樋室 伸顕

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    配分額：4810000円 （ 直接経費：3700000円 、 間接経費：1110000円 ）

    脳性麻痺児・者の移動能力低下は、社会参加の制約や疾病リスクとなる。そのため移動能力低下予防は脳性麻痺児・者へのリハビリテーションにおける喫緊の課題であるが、自然経過や原因は不明な点がおおい。私たちはこれまで、成人脳性麻痺者は早期から移動能力低下を自覚していること、粗大運動機能レベルによっ てその時期、割合、その原因と考えられることが異なることをアンケート調査によって明らかにした。さらに、移動能力低下と歩行能力の関係を知るために、臨床的に使用できる歩行・移動評価法を明らかにし、それらの妥当性と信頼性、臨床的有用性を明らかにした。本研究の目的は、脳性麻痺児・者の移動能力の変化を臨床応用可能な評価法を用いて縦断的に調査し、移動能力低下の関連因子や歩行能力との関連を明らかにすることである。そして本研究の成果を脳性麻痺児・ 者への予防的リハビリテーションの指針とすることを目指す。
    令和元年度は、歩行遂行能力を評価するABILOCO-Kidsの日本語版の信頼性・妥当性を検証し、Rasch分析によって間隔尺度化ができるようになった。
    令和元年度は昨年度データ収集を行った対象から2度目のデータ収集、さらに対象者を増やしながらデータ収集を行っている。

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