SUGITA Shintarou

写真a

Affiliation

School of Medicine, Department of Clinical Pathology

Job title

Associate Professor
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Education 【 display / non-display 】

  • 1993
    -
    1999

    University of Tsukuba   医学専門学群  

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Degree 【 display / non-display 】

  • 2011.07   University of Tsukuba   medical doctor

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Research Experience 【 display / non-display 】

  • 2023.04
    -
    Now

    札幌医科大学附属病院   病院教授

  • 2017.04
    -
    Now

    札幌医科大学医学部病理診断学   准教授

  • 2015.04
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    2017.03

    札幌医科大学医学部病理診断学   講師

  • 2013.04
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    2015.03

    札幌医科大学医学部病理診断学   助教

  • 2011.10
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    2013.03

    日立製作所日立総合病院   病理科   主任医長

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Professional Memberships 【 display / non-display 】

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    日本臨床細胞学会

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    日本病理学会

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    日本整形外科学会

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    日本癌学会

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    日本臨床分子形態学会

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Research Areas 【 display / non-display 】

  • Life sciences   Human pathology  

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Affiliation 【 display / non-display 】

  • Sapporo Medical University   School of Medicine Department of Surgical Pathology   Associate Professor  

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Research Interests 【 display / non-display 】

  • 病理診断学

  • 骨軟部腫瘍

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Papers 【 display / non-display 】

  • Ulcerative Colitis Preceding Asymptomatic Wilson’s Disease: A Case Report and Literature Review

    Jun Kunizaki, Yuko Yoto, Yoshinobu Nagaoka, Akira Ishii, Tomoe Kazama, Kohei Wagatsuma, Noriyuki Akutsu, Aki Ishikawa, Toju Tanaka, Shintaro Sugita, Takeshi Tsugawa, Hiroshi Nakase

    Gastro Hep Advances ( Elsevier BV )  4 ( 1 ) 100548 - 100548  2025

    DOI

  • Identification and phenotypic characterization of neoantigen-specific cytotoxic CD4+ T cells in endometrial cancer

    Minami Fusagawa, Serina Tokita, Kenji Murata, Tasuku Mariya, Mina Umemoto, Shintaro Sugita, Kazuhiko Matsuo, Yoshihiko Hirohashi, Tsuyoshi Saito, Takayuki Kanaseki, Toshihiko Torigoe

    Cancer Immunology Research ( American Association for Cancer Research (AACR) )   2024.12

    　View Summary

    Abstract Tumor-reactive CD4+ T cells often accumulate in the tumor microenvironment (TME) in human cancer, but their functions and roles in antitumor responses remain elusive. Here, we investigated the immunopeptidome of HLA class II–positive (HLA-II+) endometrial cancer with an inflamed TME using a proteogenomic approach. We identified HLA-II neoantigens, one of which induced polyclonal CD4+ tumor-infiltrating lymphocyte (TIL) responses. We then experimentally demonstrated that neoantigen-specific CD4+ TILs lyse target cells in an HLA-II–dependent manner. Single cell transcriptomic analysis of the TME coupled with T-cell receptor (TCR) sequencing revealed the presence of CD4+ T-cell clusters characterized by CXCL13 expression. The CXCL13+ clusters contained two subclusters with distinct cytotoxic gene expression patterns. The identified neoantigen-specific CD4+ T cells were found exclusively in one of the CXCL13+ subclusters characterized by granzyme B and CCL5 expression. These results demonstrate the involvement of tumor-reactive CD4+ T cells with cytotoxic function in immune surveillance of endometrial cancer and reveal their transcriptomic signature.

    DOI

  • Establishment and characterization of the novel myxofibrosarcoma cell line, SMU-MFS

    Naoya Nakahashi, Makoto Emori, Kohichi Takada, Yasutaka Murahashi, Junya Shimizu, Kazuyuki Murase, Tomohide Tsukahara, Shintaro Sugita, Akira Takasawa, Kousuke Iba, Atsushi Teramoto, Makoto Osanai

    Human Cell ( Springer Science and Business Media LLC )  38 ( 1 )  2024.12

    DOI

  • Secondary Osteosarcoma After Carbon‐Ion Radiotherapy for Desmoid‐Type Fibromatosis: A Case Report

    Mizuki Aketo, Makoto Emori, Kohichi Takada, Kazuyuki Murase, Yohei Arihara, Junya Shimizu, Yasutaka Murahashi, Masahiko Okamoto, Shintaro Sugita, Atsushi Teramoto

    Cancer Reports ( Wiley )  7 ( 11 )  2024.11

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    ABSTRACT Background Radiotherapy is considered an alternative treatment for unresectable or pharmacologically resistant desmoid‐type fibromatosis. While it results in relatively good local control, the risk of secondary malignancy remains a concern. Case We present a case of secondary osteosarcoma after carbon‐ion radiation therapy (CIRT). A 31‐year‐old male patient presented with left thigh pain. The tumor was located between the left gluteus maximus and gluteus medius and extended to the vastus lateralis and biceps femoris. It was diagnosed as desmoid‐type fibromatosis after needle biopsy. The patient was treated with several medications, including a cyclooxygenase 2 inhibitor and tamoxifen; however, his left thigh pain did not improve. He was treated with CIRT 1 year after diagnosis (67.2 Gy [relative biological effectiveness] 16fr/4wks). He developed osteosarcoma of the left femur 8 years later. He underwent chemotherapy and tumor excision with disarticulation of the left hip. Pulmonary metastasis was detected 6 and 17 months after the definitive surgery and excised using metastasectomy. However, he died due to the recurrence of multiple pulmonary metastases 29 months after the definitive surgery. Conclusions In this case, we believe that the low radiation dose to the femur may have caused secondary malignancy.

    DOI

  • Germline <scp><i>BRCA1</i></scp>‐Mutated Synchronous and Metachronous Pancreatic Acinar Cell Carcinoma With Long‐Term Survival

    Tomohiro Kubo, Yuki Ikeda, Joji Muramatu, Kazuma Ishikawa, Makoto Yoshida, Kazuharu Kukita, Masafumi Imamura, Shintaro Sugita, Akihiro Sakurai, Kohichi Takada

    Cancer Reports ( Wiley )  7 ( 8 )  2024.08

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    ABSTRACT Background Pancreatic acinar cell carcinoma (PACC) is a rare pancreatic neoplasm. Recently, molecular analysis revealed that PACC shows a high frequency of the BRCA1/2 mutation and is likely to be considered a cancer associated with hereditary breast and ovarian cancer (HBOC). Hereditary cancers, including HBOC, are characterized by multifocal and/or metachronous tumors. However, no case reports exist of germline BRCA1‐mutated synchronous and metachronous PACC. Case A 58‐year‐old man was diagnosed with synchronous and metachronous PACC at the age of 56 and underwent two surgeries. Ten months after the second surgery, the patient developed multiple liver metastases. Gemcitabine plus nab‐paclitaxel therapy was administered as first‐line chemotherapy. After seven cycles, computed tomography examination revealed progressive disease (PD). Therefore, modified FOLFIRINOX (mFFX) was administered as second‐ line chemotherapy. After 19 cycles of mFFX, comprehensive cancer genomic profiling (CGP) identified a BRCA1 pathogenic variant that was confirmed to be germline origin. Accordingly, we treated the patient with olaparib; however, he was diagnosed with PD after 4 months. He subsequently died 5 years and 9 months after the initial surgery, and 3 years and 10 months after chemotherapy. Based on the genetic data of the patients, his family members received genetic counseling followed by cascade testing. Consequently, the same gBRCA1 pathogenic variant was detected in the son and his surveillance for HBOC‐related cancers was initiated. Conclusion We diagnosed a 58‐year‐old man with a synchronous and metachronous PACC with germline BRCA1 pathogenic variant. Considering that PACC is likely to have BRCA1/2 mutations responsible for HBOC, we need to be aware of the possible presence of multifocal and/or metachronous tumors in patients with PACC. Additionally, patients with PACC should undergo genetic examinations, which would be beneficial in determining treatment strategies and health care for blood relatives.

    DOI

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Books and Other Publications 【 display / non-display 】

  • 腫瘍病理鑑別診断アトラス縦隔腫瘍・胸膜腫瘍第2版

    松野吉弘, 鍋島一樹( Part： Contributor, VI. 胸腺および縦隔の軟部腫瘍)

    文光堂  2022.04

  • 腫瘍病理鑑別診断アトラス骨腫瘍第2版

    小田義直, 吉田朗彦( Part： Contributor, 骨腫瘍の頻度, 年齢, 発生部位)

    文光堂  2021

  • 腫瘍病理鑑別診断アトラス悪性軟部腫瘍第1版

    長谷川匡, 小田義直( Part： Contributor, 筋上皮腫)

    文光堂  2021

  • 腫瘍病理鑑別診断アトラス骨腫瘍第2版

    小田義直, 吉田朗彦( Part： Contributor, 特殊型軟骨肉腫)

    文光堂  2021

  • 腫瘍病理鑑別診断アトラス悪性軟部腫瘍第1版

    長谷川匡, 小田義直( Part： Contributor, 隆起性皮膚線維肉腫)

    文光堂  2021

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Misc 【 display / non-display 】

  • 軟部腫瘍の遺伝子検査（FISHなど）について具体的に教えてください

    杉田真太朗

    Visual Dermatology   33 ( 3 ) 267 - 268  2024.03

    Authorship：   Lead author

  • 直腸に発生したGL11-altered soft tissue tumorの1例

    佐々木健太, 杉田真太朗, 菅原太郎, 藤田裕美, 久保輝文, 大沼啓之, 長谷川匡

    診断病理   41   69 - 73  2024.01

    Authorship：   Corresponding author

  • 病理診断クイックリファレンス2023 第17章 骨・軟部 デスモイド型線維腫症

    杉田真太朗

    病理と臨床 41(臨時増刊号)     266 - 266  2023.04

    Authorship：   Lead author

  • 病理診断クイックリファレンス2023 第17章 骨・軟部 骨肉腫

    杉田真太朗

    病理と臨床 41(臨時増刊号)     255 - 255  2023.04

    Authorship：   Lead author

  • 病理診断クイックリファレンス2023 第17章 骨・軟部 軟骨肉腫

    杉田真太朗

    病理と臨床 41(臨時増刊号)     256 - 256  2023.04

    Authorship：   Lead author

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Other 【 display / non-display 】

  • 希少がん診断のための病理医育成事業における骨軟部腫瘍画像問題提供

    2018
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    2020
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Research Projects 【 display / non-display 】

  • てんかん発作誘発機構解明のための病理組織学的研究

    基盤研究(C)

    Project Year :

    2021.04
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    2024.03
     

    三國 信啓, 杉田 真太朗

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    発作を引き起こす持続性素因を持つネットワーク病である「てんかん」において、持続性状態から突発的に発作を生じるスイッチ（病態）を明らかにすることが本研究の目的である。この目的を達成するため、申請者自身が経験豊富な病理学的基礎研究手法と、臨床的手法つまり慢性硬膜下電極による焦点診断、てんかん波解析、ネットワークとしての解剖学的機能的異常回路診断を行いその総合結果から研究を進める。当科常勤脳神経外科専門医かつ日本てんかん学会専門医6名によって例年年間40－50件の実績がある。 ところが2020年からのCOVID19感染拡大により、患者側からの延期中止要望があり、また当院でも医療体制縮小のために延期せざるを得なかった症例がある。このために2021年度の研究は十分に行えなかったと判断している。そのような状況においても、日本のてんかん外科手術の現状を把握し論文発表した。限局性皮質形成異常や腫瘍性病変、海馬硬化との病理学的重複や個体差を含め、てんかん発作を生じる病態は複雑と予想され、その全体像の解明のために手術症例を用いて前向きの系統的研究を行う。術前、術中検査として必要な長時間ビデオEEGモニタリング用デジタル脳波計、PET/SPECT、MEG、ニューロナビゲーションシステムを使用して、脳波測定と摘出脳の組織に関する研究を継続する。てんかんは、発作を引き起こす持続性素因を持つネットワーク病である。有病率は約１％で、小 児期から高齢までのどの段階にでも発生し成長を傷害し、また自動車運転を含む社会的制約を受け、さらに認知症を加速することが知られている。本疾患の病態を解明し新たな治療に貢献する本研究は学術的意義はもちろん、社会的にも有意義である。

  • Evaluation of rectal cancer aggressiveness based on conductivity imaging

    Grant-in-Aid for Scientific Research (C)

    Project Year :

    2018.04
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    2022.03
     

    畠中 正光, 山 直也, 小野寺 麻希, 杉田 真太朗, 西舘 敏彦

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    データの再現性に関して懸念があったので、現時点でデータ会で気が可能であるconductivity計算画像8症例のtexture analysisを行い、そのICCおよびその95％confidence interval(95%CI)をIVIM計算画像21例のパラメータ内最も再現性が高いと考えられているD値のICCおよびその95％CIと比較した。 Conductivityのminimum: ICC=0.752, 95%CI=0.219-0.944、25%:ICC=0.844, 95%CI=0.446-0.966, 50%: ICC=0.791, 95%CI=0.308-0.953, mean: ICC=0.745, 95%CI=0.204-0.942, 75%: ICC=0.554, 95%CI=-0.13-0.889, maximum: ICC=0.596, 95%CI=-0.069-0.902, skewness: ICC=-0.061, 95%CI=-0.673-0.625, kurtosis: ICC=0.035, 95%CI=-0.617-0.680に対し、D値のminimum: ICC=0.386, 95% CI=-0.048-0.700, 25%: ICC=0.709, 95%CI=0.405-0.873, 50%: ICC=0.829, 95%CI=0.624-0.928, mean: ICC=0.791, 95%CI=0.551-0.911, 75%: ICC=0.813, 95%CI=0.592-0.921, maximum: ICC=0.787, 95%CI=0.544-0.909, skewness: ICC=0.300, 95%CI=-0.144-0.647, kurtosis: ICC=0.636, 95%CI=0.288-0.837であった。

  • Histopathological study to elucidate the mechanism of epilepsy seizure induction

    Grant-in-Aid for Scientific Research (C)

    Project Year :

    2018.04
    -
    2022.03
     

    MIKUNI NOBUHIRO

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    Six full-time specialists of the Japanese Epilepsy Society have a record of 40-50 operations per year, but after 2020, the operations were postponed one after another due to COVID 19 compliance, and it was difficult to carry out the research. Research continues even in such a situation, and we have published manuscripts such as, (1) the gene of the excised specimen is involved in the control of epileptic seizures in WHO grade II glioma, which is frequently associated with epilepsy, (2) higher brain dufunction would be improved by early epilepsy focal excision. and (3) elucidation of the abnormal network of epilepsy. Research on electroencephalogram measurement and excised brain tissue using a digital electroencephalograph for long-term video EEG monitoring, PET / SPECT, MEG, and neuronavigation system, which are necessary for preoperative and intraoperative examinations, has been continuing although the infection has not yet converged.

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Presentations 【 display / non-display 】

  • Atypical spindle cell/pleomorphic lipomatous tumorとはなにか.

    杉田真太朗, 長谷川匡  [Invited]

    第110回日本病理学会総会 ワークショップ 2020年骨軟部腫瘍WHO分類における新規疾患概念 

    Presentation date： 2021.04

    Event date：
    2021.04
    　
    　

  • 新しい疾患概念の軟部腫瘍 組織像と細胞像

    杉田真太朗, 長谷川匡  [Invited]

    第58回日本臨床細胞学会秋期総会 ワークショップ 軟部腫瘍における細胞診の有用性 

    Presentation date： 2019.11

    Event date：
    2019.11
    　
    　

  • The current status and perspective of FISH in bone and soft tissue tumor pathology

    杉田真太朗, 長谷川匡  [Invited]

    第108回日本病理学会総会 ワークショップ 臓器病理学の最近の進歩 骨軟部腫瘍 

    Presentation date： 2019.05

    Event date：
    2019.05
    　
    　

  • 骨軟部腫瘍における遺伝子異常検索法について

    杉田真太朗, 長谷川匡  [Invited]

    第107回日本病理学会総会 ワークショップ 骨軟部腫瘍の遺伝子解析と病理診断への応用 

    Presentation date： 2018.06

    Event date：
    2018.06
    　
    　
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Committee Memberships 【 display / non-display 】

  • 2021.01
    -
    2023.06

      細胞診ガイドライン改訂ワーキンググループ上気道小委員会委員

  • 2021.01
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    2023.06

      細胞診ガイドライン改訂ワーキンググループ軟部・骨小委員会委員

  • 2018.04
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    2022.03

      「診断病理」編集委員会委員

  • 2015.01
    -
    2024.12

      Pathology International刊行委員会委員

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