YOSHIDA Makoto

写真a

Affiliation

School of Medicine, Department of Medical Oncology

Job title

Assistant Professor
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Affiliation 【 display / non-display 】

  • Sapporo Medical University   Department of Medical Oncology   assistant profeccor   Dr  

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Research Projects 【 display / non-display 】

  • Development of new treatment for colorectal cancer using metastasis control targeting sugar chain modification and a Fucose-Bound Nanoparticle.

    Grant-in-Aid for Early-Career Scientists

    Project Year :

    2019.04
    -
    2022.03
     

    Yoshida Makoto

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    Since colorectal cancer produces high tumor marker CA19-9, we have developed a new missile therapy by taking advantage of the high demand for fucose, which is the skeleton. SiRNA FUT3 / to suppress EMT by TGF-β. By encapsulating 5-FU / LV / SN38 / L-OHP, which is the standard treatment for 6 and current colorectal cancer, in F50 fucose-bound liposomes, these treatments increase CA19-9 more specifically. It was found that it was delivered to the produced colon cancer cells and had a high antitumor effect.

  • Development of novel pancreatic cancer treatment targeting c-Rel

    Grant-in-Aid for Young Scientists (B)

    Project Year :

    2017.04
    -
    2019.03
     

    YOSHIDA MAKOTO

    　View Summary

    It is known that c-Rel, one of the subunits of transcription factor NF-kB, is involved in the survival and growth of cancer cells. We found that c-Rel is a target gene of HIF-1α and induced in hypoxic environment, but it was unclear whether c-Rel inhibition would lead to cancer cell inhibition. In this time, we showed IT-901, c-Rel inhibition compound, suppresses the proliferation of pancreatic cancer cells, epithelial-mesenchymal transition and stem cell-like properties in a hypoxic environment. It turned out that c-Rel inhibition has these anti-tumor effects in hypoxic environment.

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