Degree 【 display / non-display 】

Degree 【 display / non-display 】

• 札幌医科大学   医学博士

• 札幌医科大学   医学

Research Experience 【 display / non-display 】

Research Experience 【 display / non-display 】

• 2023.04

  -

  Now

  Sapporo Medical University   微生物学兼耳鼻咽喉科頭頸部外科学   准教授

• 2018.07

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  2023.03

  Sapporo Medical University   School of Medicine, Dept.of Microbiology   講師

• 2016.04

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  2018.03

  Northwestern University   医学部免疫アレルギー部門  

• 2013.10

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  2018.06

  Sapporo Medical University School of Medicine   Microbiology and otorhinolaryngology   instructor

Research Areas 【 display / non-display 】

Research Areas 【 display / non-display 】

• Life sciences   Virology   respiratory syncytial virus

Affiliation 【 display / non-display 】

Affiliation 【 display / non-display 】

• Sapporo Medical University   医学部耳鼻咽喉科兼微生物学講座   准教授  

Research Interests 【 display / non-display 】

Research Interests 【 display / non-display 】

• アレルギー・ぜんそく

• 細胞・組織

• 免疫学

• innate immunity

• RNA virus

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Papers 【 display / non-display 】

Papers 【 display / non-display 】

• TNF induces production of type 2 cytokines in human group 2 innate lymphoid cells.

  Noriko Ogasawara, Julie A Poposki, Aiko I Klingler, Bruce K Tan, Kathryn E Hulse, Whitney W Stevens, Anju T Peters, Leslie C Grammer, Kevin C Welch, Stephanie S Smith, David B Conley, Ken-Ichi Takano, Tetsuo Himi, Robert C Kern, Robert P Schleimer, Atsushi Kato

  The Journal of allergy and clinical immunology   145 ( 1 ) 437 - 440  2020.01  [Refereed]  [International journal]

  　View Summary

  TNF receptor II is expressed on ILC2s and TNF is able to induce production of type 2 cytokines in human ILC2s. TNF may play a role in causing or amplifying type 2 immunity contributing to health and disease.

  DOI PubMed

• Role of RANK-L as a potential inducer of ILC2-mediated type 2 inflammation in chronic rhinosinusitis with nasal polyps.

  Noriko Ogasawara, Julie A Poposki, Aiko I Klingler, Bruce K Tan, Kathryn E Hulse, Whitney W Stevens, Anju T Peters, Leslie C Grammer, Kevin C Welch, Stephanie S Smith, David B Conley, Joseph R Raviv, Pejman Soroosh, Ken-Ichi Takano, Tetsuo Himi, Robert C Kern, Robert P Schleimer, Atsushi Kato

  Mucosal immunology   13 ( 1 ) 86 - 95  2020.01  [Refereed]  [International journal]

  　View Summary

  Chronic rhinosinusitis with nasal polyps (CRSwNP) is characterized by type 2 inflammation with accumulation of activated group 2 innate lymphoid cells (ILC2s) and elevation of thymic stromal lymphopoietin (TSLP). A member of the TNF superfamily (TNFSF), TNFSF15, is known to induce the production of type 2 cytokines in ILC2s. Although ILC2s have been implicated in CRSwNP, the presence and role of TNFSFs in ILC2-mediated type 2 inflammation in CRSwNP has not been elucidated. Here, we investigate the involvement of TNFSFs in ILC2-mediated type 2 inflammation in CRSwNP. We found that receptor activator of NF-κB (RANK) ligand (RANK-L (TNFSF11)) was significantly elevated in nasal polyps (NPs), and that the receptor of RANK-L, RANK, was expressed on ILC2s in human peripheral blood and NPs. An agonistic antibody against RANK induced production of type 2 cytokines in human ILC2s, and TSLP significantly enhanced this reaction. The membrane-bound RANK-L was detected mainly on CD45 + immune cells, including TH2 cells in NPs. The co-culture of NP-derived ILC2s and TH2 cells significantly enhanced production of type 2 cytokines, and anti-RANK-L monoclonal antibody suppressed this enhancement. In conclusion, RANK-L, together with TSLP, may play an inductive role in the ILC2-mediated type 2 inflammation in CRSwNP.

  DOI PubMed

• Epithelial activators of type 2 inflammation: Elevation of thymic stromal lymphopoietin, but not IL-25 or IL-33, in chronic rhinosinusitis with nasal polyps in Chicago, Illinois.

  Noriko Ogasawara, Aiko I Klingler, Bruce K Tan, Julie A Poposki, Kathryn E Hulse, Whitney W Stevens, Anju T Peters, Leslie C Grammer, Kevin C Welch, Stephanie S Smith, David B Conley, Robert C Kern, Robert P Schleimer, Atsushi Kato

  Allergy   73 ( 11 ) 2251 - 2254  2018.11  [Refereed]  [International journal]

  DOI PubMed

• Up-regulation of serum periostin and squamous cell carcinoma antigen levels in infants with acute bronchitis due to respiratory syncytial virus.

  Hiroaki Nakamura, Kenichi Akashi, Masako Watanabe, Shoichiro Ohta, Junya Ono, Yoshinori Azuma, Noriko Ogasawara, Keisuke Yamamoto, Norikazu Shimizu, Hiroyuki Tsutsumi, Kenji Izuhara, Toshio Katsunuma

  Allergology international : official journal of the Japanese Society of Allergology   67 ( 2 ) 259 - 265  2018.04  [Refereed]  [International journal]

  　View Summary

  BACKGROUND: Periostin and squamous cell carcinoma antigen (SCCA) are involved in the pathogenesis of asthma. Acute bronchitis due to respiratory syncytial virus (RSV) infection during infancy exhibits an asthma-like pathogenesis, suggesting that it may be associated with the subsequent development of asthma. However, the mechanism by which RSV infection leads to development of asthma has not yet been fully elucidated. METHODS: Infants younger than 36 months were enrolled and classified into three groups. Group I included patients hospitalized with RSV-induced bronchitis. These patients were further stratified into two sub-groups according to whether the criteria for the modified Asthma Predictive Index (mAPI) had been met: Group I consisted of mAPI (+) and mAPI (-) patients; Group II included patients with food allergy as a positive control group; and Group III included children with no allergy as a negative control group. Serum periostin and SCCA levels were measured in the groups. This study was registered as a clinical trial (UMIN000012339). RESULTS: We enrolled 14 subjects in Group I mAPI (+), 22 in Group I mAPI (-), 18 in Group II, and 18 in Group III. In Group I, the serum periostin and SCCA levels were significantly higher during the acute phase compared with the recovery phase. However, no significant differences were found between Group I mAPI (+) and mAPI (-). CONCLUSIONS: The serum periostin and SCCA levels increased during acute RSV bronchitis. Both periostin and SCCA may play a role in the pathogenesis of acute bronchitis due to RSV.

  DOI PubMed

• IL-10, TGF-β, and glucocorticoid prevent the production of type 2 cytokines in human group 2 innate lymphoid cells.

  Noriko Ogasawara, Julie A Poposki, Aiko I Klingler, Bruce K Tan, Ava R Weibman, Kathryn E Hulse, Whitney W Stevens, Anju T Peters, Leslie C Grammer, Robert P Schleimer, Kevin C Welch, Stephanie S Smith, David B Conley, Joseph R Raviv, Pejman Soroosh, Omid Akbari, Tetsuo Himi, Robert C Kern, Atsushi Kato

  The Journal of allergy and clinical immunology ( Mosby Inc. )  141 ( 3 ) 1147 - 1151  2018.03  [Refereed]  [International journal]

  DOI PubMed

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Misc 【 display / non-display 】

Misc 【 display / non-display 】

• ウイルス感染症での鼻粘膜上皮における細気管支炎・喘鳴の発症予測因子としての鼻汁microRNAの可能性

  山本 圭佑, 小笠原 徳子, 大國 毅, 高野 賢一, 堤 裕幸, 氷見 徹夫

  日本鼻科学会会誌 ( (一社)日本鼻科学会 )  56 ( 3 ) 484 - 484  2017.09

• クラリスロマイシンは気道上皮細胞でRSウイルスによって誘導されるインターフェロンの産生をIRF-3を介して調整する

  山本 圭佑, 小笠原 徳子, 高野 賢一, 氷見 徹夫

  耳鼻咽喉科免疫アレルギー ( 日本耳鼻咽喉科免疫アレルギー学会 )  35 ( 2 ) 188 - 189  2017.08

• クラリスロマイシンは気道上皮でRSVによって誘導されるインターフェロンIRF-3を介して調整する

  山本 圭佑, 小笠原 徳子, 高野 賢一, 宮田 遼, 角木 拓也, 亀倉 隆太, 氷見 徹夫

  日本耳鼻咽喉科学会会報 ( (一社)日本耳鼻咽喉科学会 )  120 ( 4 ) 601 - 601  2017.04

• ウイルス、細菌、真菌 クラリスロマイシンは気道上皮細胞でRSウイルスによって誘導されるインターフェロンの産生をIRF-3を介して調整する

  山本 圭佑, 小笠原 徳子, 山本 聡, 堤 裕幸, 氷見 徹夫, 横田 伸一

  The Japanese Journal of Antibiotics ( (公財)日本感染症医薬品協会 )  70 ( Suppl.A ) 19 - 24  2017.03

  　View Summary

  患者の手術で採取した鼻粘膜から作製したhTERT導入鼻粘膜上皮細胞(hTERT-HNEC)、肺胞上皮由来細胞株(A549)、ヒト気道上皮細胞株(BEAS-2B)を用い、ヒト気道上皮細胞における急性呼吸器ウイルス感染症に対するクラリスロマイシン(CAM)の効果と、CAMのもつ免疫調節効果のメカニズムを調べるため各種検討した。RSウイルス(RSV)感染のCAMの影響を調べ、CAMがRSV増殖に影響を与えないことが示唆された。hTERT-HNEC、A549、BEAS-2Bなどの気道上皮細胞においてPoly:C処置、RSV感染で誘導されるIFN-β、IFN-λがCAMにより強く抑制された。宿主の自然免疫に関わる転写因子IRF、NF-κB、AP-1の結合領域を含むプロモーター活性化がCAMにより強く抑制された。

• マクロライド作用機序 クラリスロマイシンの炎症反応修飾作用の分子機構の解明 気道上皮細胞のクラリスロマイシン結合タンパク質の同定と機能解析

  横田 伸一, 山本 聡, 小笠原 徳子, 植村 知加, 高谷 芳明, 伊藤 英晃, 山本 圭佑, 白石 宗, 佐藤 豊孝, 氷見 徹夫

  The Japanese Journal of Antibiotics ( (公財)日本感染症医薬品協会 )  70 ( Suppl.A ) 60 - 64  2017.03

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Awards 【 display / non-display 】

Awards 【 display / non-display 】

• 学会賞

  2023.04   日本耳鼻咽喉科免疫アレルギー感染症学会  

Research Projects 【 display / non-display 】

Research Projects 【 display / non-display 】

• RSウイルスに対する局所投与型治療薬開発および重症化予測因子同定のための基礎研究

  Project Year :

  2024.10

  -

  2028.09

   

  Authorship： Principal investigator

• 分泌型免疫グロブリン受容体のレパトア解析に基づいた上気道粘膜上皮多様性解析

  挑戦的研究(萌芽)

  Project Year :

  2023.06

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  2025.03

   

  小笠原 徳子

• Development of RS virus vaccine using novel cytoplasmic RNA viral vector BC-PIV

  ワクチン開発

  Project Year :

  2023.04

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  2027.03

   

  Authorship： Coinvestigator(s)

• Identification of host factors for Respiratory syncytial virus

  Grant-in-Aid for Scientific Research (C)

  Project Year :

  2022.04

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  2025.03

   

  山本 聡, 小笠原 徳子, 高澤 啓

• ヒトNALT新奇細胞群解析に基づいたニューモウイルス生活環の解明

  Project Year :

  2022.04

  -

  2029.03

   

  Authorship： Principal investigator

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Teaching Experience 【 display / non-display 】

Teaching Experience 【 display / non-display 】

• 耳鼻咽喉科学  

  札幌医科大学  

• 微生物学  

  札幌医科大学