Updated on 2026/08/07

写真a

 
MEIJISOE Aung
 
Organization
School of Medicine Department of Hygiene Lecturer
Title
Lecturer
ORCID ID
0000-0002-8402-5349
External link

Degree

  • PhD of Medical Science ( 2016.2   Sapporo Medical University )

  • MD ( 1999.3   University of Medicine 1, Yangon )

Research History

  • Sapporo Medical University   Department of Social Medicine, Division of Hygiene   Assistant professor

    2014.7

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  • University of Sabah Malaysia, School of Medicine   Department of Pathobiology   lecturer

    2012.4 - 2014.3

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    Country：Malaysia

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  • National Health Laboratory, Myanmar

    2002.4 - 2011.3

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    Country：Myanmar

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Papers

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Research Projects

  • Molecular epidemiological study of Gram-positive cocci in Japan regarding novel resistance mechanisms to linezolid

    Grant number：21K10401  2021.4 - 2024.3

    Japan Society for the Promotion of Science  Grants-in-Aid for Scientific Research  Grant-in-Aid for Scientific Research (C)

    Aung Meijisoe

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    Grant amount：\4160000 （ Direct Cost: \3200000 、 Indirect Cost：\960000 ）

    Linezolid is one of the antimicrobials used to treat infection with drug-resistant Gram-positive bacteria such as methicillin-resistant Staphylococcus aureus. In this study, we investigated the distribution of linezolid-resistant bacteria and resistance genes in Hokkaido. As a result, one isolate of enterococcus non-susceptible to linezolid was detected. This isolate had the resistance gene optrA and was genetically similar to previously reported Asian strains. Although linezolid resistance was not detected in Staphylococcus, there were differences in susceptibility to linezolid depending on the bacterial species/lineages. Some lineages of Staphylococcus aureus and some species of coagulase-negative staphylococci showed a tendency toward decreased susceptibility.

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  • 新興感染起因菌S.capitis病原クローンの蔓延と世界的拡大の分子機序の解明

    Grant number：26K13176  2026.4 - 2029.3

    日本学術振興会  科学研究費助成事業  基盤研究(C)

    小林 宣道

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    Grant amount：\4420000 （ Direct Cost: \3400000 、 Indirect Cost：\1020000 ）

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  • Molecular epidemiology and comprehensive exploration of novel virulence factors and their action mechanisms of hypervirulent Staphylococcus in Asia

    Grant number：23KK0171  2023.9 - 2027.3

    Japan Society for the Promotion of Science  Grants-in-Aid for Scientific Research  Fund for the Promotion of Joint International Research (International Collaborative Research)

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    Grant amount：\21060000 （ Direct Cost: \16200000 、 Indirect Cost：\4860000 ）

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  • Epidemiological and Whole-Genome Analysis of Bacteria Originating from Living Environments Based on the One Health Approach

    Grant number：21K10417  2021.4 - 2025.3

    Japan Society for the Promotion of Science  Grants-in-Aid for Scientific Research  Grant-in-Aid for Scientific Research (C)

    Urushibara Noriko

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    Grant amount：\3770000 （ Direct Cost: \2900000 、 Indirect Cost：\870000 ）

    Pathogenic microorganisms often exhibit host specificity, but some can infect multiple animal species. Host switching can lead to the emergence of new pandemics and contribute to the spread of antimicrobial resistance (AMR) genes. Therefore, addressing AMR requires a comprehensive approach that encompasses not only human medicine, but also animals, food, and the environment: a One Health approach.
    This study aimed to provide data to support AMR surveillance by investigating the spread of pathogenic microorganisms between livestock, meat products, and humans. We conducted a molecular epidemiological analysis of Staphylococcus species and related genera isolated from commercially available meat products and performed phylogenetic analysis of livestock-associated MRSA in Asia using bioinformatics approaches.

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  • Molecular epidemiological study of novel species and emerging drug-resistant staphylococcus in Japan and Asia, and basic construction of their infection control

    Grant number：20H03933  2020.4 - 2024.3

    Japan Society for the Promotion of Science  Grants-in-Aid for Scientific Research  Grant-in-Aid for Scientific Research (B)

    Kobayashi Nobumichi

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    Grant amount：\17680000 （ Direct Cost: \13600000 、 Indirect Cost：\4080000 ）

    In this study, we investigated the prevalence and characteristics of new species of staphylococcus, i.e., S. argenteus, and emerging clones of methicillin-resistant Staphylococcus aureus (MRSA) in Japan (Hokkaido) and Asia (Bangladesh, Myanmar). Some clones of S. argenteus were found to be distributed at low frequencies in Japan and two Asian countries. It was revealed that a specific group of MRSA (CC1) has recently been increasing in Hokkaido, and that MRSA strains resembling to those prevalent in the United States are distributed at low frequencies. It was characteristic in the two Asian countries that proportions of S. aureus isolates having PVL toxin gene associated with increased pathogenicity were considerably higher than in Japan.

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  • Molecular epidemiology of Staphylococcus aureus, MRSA having novel enterotoxins and virulence factors

    Grant number：18K10054  2018.4 - 2021.3

    Japan Society for the Promotion of Science  Grants-in-Aid for Scientific Research  Grant-in-Aid for Scientific Research (C)

    Aung Meiji Soe

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    Grant amount：\4420000 （ Direct Cost: \3400000 、 Indirect Cost：\1020000 ）

    Prevalence of novel staphylococcal enterotoxin (SE)(-like) toxin genes in Staphylococcus aureus and its relative species S. argenteus, and their molecular epidemiological characteristics were analyzed. selw and selx were detected in more than 80% of S. aureus isolates examined, and showed diversity in their nucleotide sequences. S. aureus harbored sey and selz at low rate, without having sel26 and sel27. The sey gene was detected in all the ST2250 S. argenteus isolates, and more than half of this lineage harbored selz, sel26, and sel27. Prevalence of novel SE(-like) genes was revealed to be different depending on lineages of S. aureus and S. argenteus.

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  • How the staphylococcal species acquire resistance, and how they exchange genetic information?

    Grant number：18K10055  2018.4 - 2021.3

    Japan Society for the Promotion of Science  Grants-in-Aid for Scientific Research  Grant-in-Aid for Scientific Research (C)

    Urushibara Noriko

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    Grant amount：\4290000 （ Direct Cost: \3300000 、 Indirect Cost：\990000 ）

    MRSA infection is an ongoing challenge. Staphylococcal species exchange genetic information through staphylococcal cassette chromosome (SCC). It encompasses not only drug resistance genes but also diverse genes useful for better adaptation to the unfriendly environment. The present study has aimed to reveal how the mobile genetic elements emerged, evolved, and spread among staphylococcal species. SCC elements obtained from MRSA clinical isolates were determined for their nucleotide sequences, and compared with staphylococcal genomes deposited in a public databank. Following two novel elements were identified: a novel subtype of type IX SCC carrying mec gene (SCCmec) in Myanmar MRSA, an SCC in MRSA from including speG and a staphylococcal surface protein coding gene (sasG) in Japanese MRSA. Obtained data suggests that they have originated in coagulase-negative staphylococcal species.

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  • Analysis of present status and comprehensive molecular epidemiology of emerging drug-resistant bacteria in developing regions of Asia and Caribbean province

    Grant number：17H04664  2017.4 - 2020.3

    Japan Society for the Promotion of Science  Grants-in-Aid for Scientific Research  Grant-in-Aid for Scientific Research (B)

    Kobayashi Nobumichi

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    Grant amount：\17940000 （ Direct Cost: \13800000 、 Indirect Cost：\4140000 ）

    In three countries in Asia and Caribbean regions (Bangladesh, Myanmar, and Cuba) where information on antimicrobial resistance (AMR) is insufficient, resistance rates to various antimicrobials, prevalence of genes associated with AMR and virulence, genetic characteristics of drug-resistant isolates were analyzed for major pathogenic bacterial species (Escherichia coli, Klebsiella pneumoniae, Acinetobacter, Staphylococccus aureus, Enterococcus). As a result, it was revealed that various beta-lactamase genes have been widely distributed to Gram-negative rods represented by E. coli, and virulence factor PVL (Panton-Valentine leukocidin) associated with increased pathogenicity has been prevalent at relatively high rate among methicillin-resistant S. aureus (MRSA).

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  • Study on prevalence and molecular epidemiological characteristics of novel community-acquired MRSA that emerged in Japan

    Grant number：26460804  2014.4 - 2018.3

    Japan Society for the Promotion of Science  Grants-in-Aid for Scientific Research  Grant-in-Aid for Scientific Research (C)

    Kobayashi Nobumichi, KAWAGUCHIYA Mitsuyo, AUNG Meijisoe, ITO Masahiko, SHINAGAWA Masaaki

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    Grant amount：\4940000 （ Direct Cost: \3800000 、 Indirect Cost：\1140000 ）

    Methicillin-resistant Staphylococcus aureus (MRSA) is drug-resistant bacteria known for a long time. Recently, two MRSA clones with novel genetic traits (①MRSA harboring SCCmec-IVl which is a novel genetic complex; ②Coagulase type-II MRSA having ACME which is a genetic complex related to attachment to human skin) have been reported. We investigated their prevalence in clinical isolates in Hokkaido, Japan. These MRSA ①, ② were detected in 3.5% and 5.1% of isolates from outpatients of community, and 3% and 0.9% of isolates from a university hospital, respectively. Genetic diversity was found in MRSA with ACME, and their spread in the community and hospitals was concerned.

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