ENATSU Rei

写真a

Affiliation

School of Medicine, Department of Neurosurgery

Job title

Lecturer
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Education 【 display / non-display 】

  • 2003
    -
    2007

    Kyoto University, Graduate school of medicine  

  • 1994
    -
    2000

    Kyushu University   School of Medicine   医学科  

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Research Experience 【 display / non-display 】

  • 2018.10
    -
    Now

    Sapporo Medical University   脳神経外科   講師

  • 2014.10
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    2018.09

    Sapporo Medical University   脳神経外科   助教

  • 2013.09
    -
    2014.09

    国立病院機構姫路医療センター   脳神経外科   医員

  • 2012.08
    -
    2013.08

    Cleveland Clinic   Department of Neurosurgery   Clinical fellow

  • 2008.09
    -
    2012.07

    Cleveland Clinic   Epilepsy center   Research fellow

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Professional Memberships 【 display / non-display 】

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    日本てんかん学会

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    日本生体磁気学会

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    日本リハビリテーション学会

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    日本脳神経血管内治療学会

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    日本脳卒中の外科学会

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Research Areas 【 display / non-display 】

  • Life sciences   Neurosurgery  

  • Life sciences   Nervous system function  

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Affiliation 【 display / non-display 】

  • Sapporo Medical University   脳神経外科  

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Research Interests 【 display / non-display 】

  • てんかん

  • 不随意運動症

  • 脳内ネットワーク

  • 皮質-皮質間誘発電位

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Papers 【 display / non-display 】

  • Clinical significance of intraoperative bidirectional corticocortical evoked potential monitoring to evaluate language function.

    Chie Kamada, Yusuke Kimura, Shoto Yamada, Ryohei Saito, Katsuya Komatsu, Rei Enatsu, Yukinori Akiyama, Nobuhiro Mikuni

    Journal of neurosurgery     1 - 9  2025.01  [International journal]

    　View Summary

    OBJECTIVE: Awake craniotomy is commonly used to resect lesions located near the language area during brain surgery. However, it is often difficult to perform language tasks due to several limitations such as difficulty in awakening during surgery and intraoperative seizures. This study investigated the clinical significance of bidirectional corticocortical evoked potential (CCEP) monitoring as a new approach to evaluate intraoperative language function. METHODS: This study enrolled 12 patients who underwent awake brain tumor resection with intraoperative CCEP monitoring to assess language function. Electrodes were placed on the frontal and temporoparietal lobes based on the location of the arcuate fasciculus identified with preoperative diffusion tensor imaging to measure CCEPs intraoperatively in two directions: from the frontal lobe to the temporoparietal lobe of the language-dominant side, and vice versa. Correlations between CCEP amplitudes or latencies before and after tumor removal in each direction and postoperative language function assessed with the Western Aphasia Battery were analyzed. RESULTS: Nine of the 12 patients showed language-related CCEP responses in both directions before, during, and after tumor removal. One patient who showed decreased CCEP amplitudes in both directions after tumor removal exhibited aphasia for as long as 1 month postoperatively. In contrast, of the 6 patients whose CCEP amplitude in only a single direction was reduced or disappeared, 4 had no deterioration of language function and the other 2 had temporary deterioration of language function during the 1st postoperative week, which improved by 1 month postoperatively. CONCLUSIONS: This study indicated that bidirectional CCEP measurement may increase the precision of intraoperative language function monitoring.

    DOI PubMed

  • Functional Brain Mapping Using Depth Electrodes

    Chie Kamada, Rei Enatsu, Seiichiro Imataka, Aya Kanno, Satoko Ochi, Nobuhiro Mikuni

    World Neurosurgery ( Elsevier BV )  188   e288 - e296  2024.08

    DOI

  • An anatomo-functional study of the interactivity between the paracentral lobule and the primary motor cortex.

    Yusuke Kimura, Shoto Yamada, Katsuya Komatsu, Rei Enatsu, Ryota Sato, Chie Kamada, Ayaka Sasagawa, Tsukasa Hirano, Masayasu Arihara, Nobuhiro Mikuni

    Journal of neurosurgery     1 - 9  2024.05  [International journal]

    　View Summary

    OBJECTIVE: The purpose of this study was to understand the anatomical and functional connections between the paracentral lobule (PCL) and the primary motor cortex (M1) of the human brain. METHODS: This retrospective study included 16 patients who underwent resection of lesions located near M1. Nine patients had lesions in the dominant hemisphere. Tractography was performed to visualize the connectivity between two regions of interest (ROIs)-the convexity and the interhemispheric fissure-that were shown by functional MRI to be activated during a finger tapping task. The number, mean length, and fractional anisotropy (FA) of the fibers between the ROIs were estimated. During surgery, subdural electrodes were placed on the brain surface, including the ROIs, using a navigation system. Cortico-cortical evoked potentials (CCEPs) were evoked by applying electrical stimuli to the hand region of M1 using electrodes placed on the convexity and were measured with electrodes placed on the interhemispheric fissure. To verify CCEP bidirectionality, electrical stimuli were applied to electrodes on the interhemispheric fissure that showed CCEP responses. Correlations of CCEP amplitudes and latencies with the number, mean length, and mean FA value obtained from tractography were determined. The correlations between these parameters and perioperative motor functions were also analyzed. RESULTS: Fibers of 14 patients were visualized by diffusion tensor imaging (DTI). Unidirectional CCEPs between the PCL and M1 were measurable in all 16 patients, and bidirectional CCEPs between them were measurable in 14 patients. There was no significant difference between the two directions in the maximum CCEP amplitude or latency (amplitude, p = 0.391; latency, p = 0.583). Neither the amplitude nor latency showed any apparent correlation with the number, mean length, or mean FA value of the fibers obtained from tractography. Pre- and postoperative motor function of the hands was not significantly correlated with CCEP amplitude or latency. The number and mean FA value of fibers obtained by DTI, as well as the maximum CCEP amplitude, varied between patients. CONCLUSIONS: This study demonstrated an anatomical connection and a bidirectional functional connection between the PCL, including the supplementary motor area, and M1 of the human brain. The observed variability between patients suggests possible motor function plasticity. These findings may serve as a foundation for further studies.

    DOI PubMed

  • 【臨床てんかん学における最新の話題】最新のてんかん外科治療

    江夏 怜

      40   36 - 45  2023.12  [Refereed]  [Invited]

  • 【大脳白質解剖と脳内ネットワーク2024 脳機能と脳科学がみえる】大脳白質解剖・脳内ネットワークのTips 脳内ネットワーク解明とその歴史

    江夏 怜

    脳神経外科速報   33 ( 6 ) 770 - 771  2023.11  [Invited]

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Books and Other Publications 【 display / non-display 】

  • すぐに役立つ脳神経外科救急ハンドブック 改訂3版：各種分類・スコア・スケールのダウンロードシート付き

    江夏 怜( Part： Contributor, ２．検査と診断 Ⅱその他の検査・診断 １脳波)

    メディカ出版  2024.09 ISBN: 4840485259

    ASIN

  • 脳機能解明の歴史 意識の座はどこにある？

    江夏怜( Part： Sole author)

    日本橋出版  2024.04 ISBN: 4434338080

    ASIN

  • 脳波超入門: 脳波判読の基礎からレポート、頭蓋内脳波まで／「読みどころ」が分かる解説動画付き！

    江夏 怜( Part： Sole author)

    メディカ出版  2024.01 ISBN: 4840484600

    ASIN

  • 術式と術前～術中～術後を見わたす 手術の見取り図

    小木曽 謙太( Part： Supervisor (editorial), ５．脳神経外科,)

    株式会社 照林社  2023

  • Clinical Neuroscience

    江夏 怜( Part： Contributor, 【脳波の読み方-up to date】特殊な脳波 皮質皮質間誘発電位(CCEP))

    中外医学社  2022

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Misc 【 display / non-display 】

  • 日本武術の上肢立関節技における関節運動方向による分類

    江夏 怜

    武道学研究   54 ( 2 ) 141 - 148  2022.03  [Refereed]

  • 特集序章 “気絶”を引き起こす！ 武術の技のメカニズム

    江夏 怜

    月刊秘伝2021年10月号     16 - 19  2021.10  [Invited]

  • USMLE体験記—裏技と落とし穴

    江夏 怜

    脳神経外科   46 ( 12 ) 1121 - 1125  2018.12  [Refereed]

  • 難治性てんかんに対して迷走神経刺激療法を導入した3例

    木村修平, 信田大喜子, 辻岡孝郎, 内田雅也, 上野倫彦, 白石秀明, 笹森徹, 寳金清博, 江夏怜, 越智さと子, 三國信啓, 佐野仁美

    日本小児科学会雑誌 ( (公社)日本小児科学会 )  121 ( 11 ) 1890 - 1890  2017.11

    J-GLOBAL

  • PCASに対する神経集中治療 軽度低体温施行症例における異常脳波所見

    宮田 圭, 喜屋武 玲子, 成松 英智, 江夏 怜, 三國 信啓, 臼井 桂子, 長峯 隆, 西田 絢一, 國分 宣明

    Neurosurgical Emergency ( (NPO)日本脳神経外科救急学会 )  20 ( 3 ) 445 - 445  2016.01

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Awards 【 display / non-display 】

  • 平成27年度研究褒賞受賞

    2016.03   公益財団法人てんかん治療研究振興財団   皮質－皮質間誘発電位を用いた脳内ネットワーク研究

    Winner： 江夏 怜

  • Handa Hajime Prize

    2015.02   Kyoto Neurosurgery Camphor tree Forum   Connections of the limbic network: a corticocortical evoked potentials study

    Winner： 江夏 怜

  • 2014 Juhn and Mary Wada Prize

    2014.10   The Japan Epilepsy Society   Cortical negative motor network in comparison with sensorimotor network: a cortico-cortical evoked potential study.

    Winner： 江夏 怜

  • Best poster award in the Stereotactic and Functional Section

    2013.10   Congress of neurological surgeons 2013   Connections of the limbic network: a corticocortical evoked potentials study

  • Third place best poster award

    2013.05   81st AANS Annual Scientific Meeting   Posterior cingulate epilepsy: clinical and neurophysiological analysis

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Research Projects 【 display / non-display 】

  • 脳溝内の皮質機能の解明

    脳溝内の皮質機能の解明

    Project Year :

    2019
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    2021
     

    Authorship： Principal investigator

  • Expolaration of epileptic networks using cortico-cortical evoked potential

    Grant-in-Aid for Scientific Research (C)

    Project Year :

    2016.04
    -
    2019.03
     

    Enatsu Rei

    　View Summary

    The aim of this study is to explore the epileptic networks using cortico-cortical evoked potentials. We recorded the cortico-cortical evoked potentials in the stimulation of epileptogenic regions in 33 patients, and are analyzing the data. Furthermore, in association with this study, we have reported the networks of frontal aslant tract, basal temporal language areas, auditory cortex, and distribution of eloquent cortices and afterdischarges in the electrical cortical stimulation.

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Presentations 【 display / non-display 】

  • Cortico-cortical evoked potentials: The Cleveland Clinic experience.

    Enatsu R  [Invited]

    11th European congress of epileptology 

    Event date：
    2014.06
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    2014.07

  • Functional brain mapping with depth electrodes

    Rei Enatsu, Chie Kamada, Aya Kanno, Satoko Ochi, Nobuhiro Mikuni

    American Epilepsy Society, 2023 annual meeting: 2023 Dec 1- 5: Orland, USA 

    Presentation date： 2024.12

    Event date：
    2024.12
    　
    　

  • SEEG-伝統的手法と実用の工夫

    江夏 怜  [Invited]

    Presentation date： 2023.12

    Event date：
    2023.11
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    2023.12

  • 江夏 怜、三國 信啓, 皮質-皮質間誘発電位(CCEP)とてんかん病態

    江夏怜  [Invited]

    日本脳神経外科学会第82回学術総会、2023年10月25-27日、横浜 

    Presentation date： 2023.10

    Event date：
    2023.10
    　
    　

  • ブレインラボ手術支援ロボットアームCirqシステムを使用した深部電極留置.

    江夏 怜, 菅野 彩, 三國 信啓  [Invited]

    第55回日本てんかん学会学術集会 

    Event date：
    2022.09
    　
    　

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Teaching Experience 【 display / non-display 】

  • 大学院生 脳機能講義  

    2015.04
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    Now
     

  • 機能的脳神経外科  

    2014.10
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    Now
     

  • 臨床入門  

    2014.10
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    Now
     

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Committee Memberships 【 display / non-display 】

  • 2020.10
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    Now

      評議員、国際関連委員会委員、編集委員会委員、ガイドライン作成委員会委員

  • 2018.12
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    2020.12

      Epilepsy Surgery Education Task force

  • 2013.10
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    Now

      評議員、英文ジャーナル委員会委員、デバイス等技術資格認定委員会委員、移行期医療検討委員会委員

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      NMC査読委員

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