ENATSU Rei

写真a

Affiliation

School of Medicine, Department of Neurosurgery

Job title

Lecturer
To the head of this page.▲

Education 【 display / non-display 】

  • 2003
    -
    2007

    Kyoto University, Graduate school of medicine  

  • 1994
    -
    2000

    Kyushu University   School of Medicine   医学科  

To the head of this page.▲

Research Experience 【 display / non-display 】

  • 2018.10
    -
    Now

    Sapporo Medical University   脳神経外科   講師

  • 2014.10
    -
    2018.09

    Sapporo Medical University   脳神経外科   助教

  • 2013.09
    -
    2014.09

    国立病院機構姫路医療センター   脳神経外科   医員

  • 2012.08
    -
    2013.08

    Cleveland Clinic   Department of Neurosurgery   Clinical fellow

  • 2008.09
    -
    2012.07

    Cleveland Clinic   Epilepsy center   Research fellow

display all >>

To the head of this page.▲

Professional Memberships 【 display / non-display 】

  • 　
    　
    　

    日本脳神経血管内治療学会

  • 　
    　
    　

    日本脳卒中の外科学会

  • 　
    　
    　

    International League Against Epilepsy

  • 　
    　
    　

    日本脳神経外科学会

  • 　
    　
    　

    Congress of Neurological Surgeons

display all >>

To the head of this page.▲

Research Areas 【 display / non-display 】

  • Life sciences   Neurosurgery  

  • Life sciences   Nervous system function  

To the head of this page.▲

Affiliation 【 display / non-display 】

  • Sapporo Medical University   脳神経外科  

To the head of this page.▲
 

Research Interests 【 display / non-display 】

  • てんかん

  • 不随意運動症

  • 脳内ネットワーク

  • 皮質-皮質間誘発電位

To the head of this page.▲

Papers 【 display / non-display 】

  • How do you teach/master Neurosurgicalテクニック?脳波編(第14回) 皮質刺激による脳機能マッピング

    江夏 怜

    脳神経外科速報 ( (株)メディカ出版 )  33 ( 4 ) 540 - 550  2023.07

  • Computational Fluid Dynamics Analysis Features in Aneurysm Development in Rats.

    Shoichi Komura, Katsuya Komatsu, Takeshi Mikami, Yukinori Akiyama, Sangnyon Kim, Rei Enatsu, Hiroshi Nagahama, Nobuhiro Mikuni

    Neurologia medico-chirurgica   63 ( 6 ) 250 - 257  2023.06  [Domestic journal]

    　View Summary

    The investigation of how to control the development and growth of cerebral aneurysms is important for the prevention of subarachnoid hemorrhage. Although there have been several types of research studies on computational fluid dynamics (CFD) analysis of brain aneurysm development and growth, there has been no unified interpretation of the CFD analysis results. The purpose of this study is to clarify the characteristics of CFD analysis results related to the development of cerebral aneurysms using an animal model. Nineteen rat models of cerebral aneurysms were created, and the CFD analysis results between the cerebral aneurysm group [n = 10; the aneurysm was observed on magnetic resonance angiography (MRA) within 10 weeks after aneurysm induction surgery] and the nonaneurysm group (n = 9) were compared. All aneurysms were confirmed on the proximal segment of the left cerebral artery (P1), and the cross-sectional area and curvature of the left P1 were evaluated together. In the cerebral aneurysm group, there was a decrease in wall shear stress (WSS) that is consistent with the location of the aneurysm compared to the nonaneurysm group. The cross-sectional area of the left P1 gradually increased in the aneurysm group but not in the nonaneurysm group. The mean curvature in the entire left P1 was higher in the aneurysm group than in the nonaneurysm group. This study revealed that the development of cerebral aneurysms is due to changes in vascular morphology, namely, an increase in vessel diameter and a high curvature, and a decreased WSS consistent with the site of aneurysm development using this animal model.

    DOI PubMed

  • Microbleeds Due to Reperfusion Enhance Early Seizures after Carotid Ligation in a Rat Ischemic Model.

    Takuro Saito, Takeshi Mikami, Tsukasa Hirano, Hiroshi Nagahama, Rei Enatsu, Katsuya Komatsu, Satoshi Okawa, Yukinori Akiyama, Nobuhiro Mikuni

    Neurologia medico-chirurgica   63 ( 6 ) 228 - 235  2023.06  [Domestic journal]

    　View Summary

    Impaired reperfusion in ischemic brain disease is a condition that we are increasingly confronted with owing to recent advances in reperfusion therapy. In the present study, rat models of reperfusion were investigated to determine the causes of acute seizures using magnetic resonance imaging (MRI) and histopathological specimens. Rat models of bilateral common carotid artery ligation followed by reperfusion and complete occlusion were created. We compared the incidence of seizures, mortality within 24 h, MRI, and magnetic resonance spectroscopy (MRS) to evaluate ischemic or hemorrhagic changes and metabolites in the brain parenchyma. In addition, the histopathological specimens were compared with those observed on MRI. In multivariate analysis, the predictive factors of mortality were seizure (odds ratios (OR), 106.572), reperfusion or occlusion (OR, 0.056), and the apparent diffusion coefficient value of the striatum (OR, 0.396). The predictive factors of a convulsive seizure were reperfusion or occlusion (OR, 0.007) and the number of round-shaped hyposignals (RHS) on susceptibility-weighted imaging (SWI) (OR, 2.072). The incidence of convulsive seizures was significantly correlated with the number of RHS in the reperfusion model. RHS on SWI was confirmed pathologically as microbleeds in the extravasation of the brain parenchyma and was distributed around the hippocampus and cingulum bundle. MRS analysis showed that the N-acetyl aspartate level was significantly lower in the reperfusion group than in the occlusion group. In the reperfusion model, RHS on SWI was a risk factor for convulsive seizures. The location of the RHS also influenced the incidence of convulsive seizures.

    DOI PubMed

  • Transcranial electrical stimulation technique for induction of unilateral motor evoked potentials.

    Shoto Yamada, Rei Enatsu, Shu Ishikawa, Yusuke Kimura, Katsuya Komatsu, Tomohiro Chaki, Yukinori Akiyama, Takeshi Mikami, Nobuhiro Mikuni

    Clinical neurophysiology : official journal of the International Federation of Clinical Neurophysiology   150   194 - 196  2023.06  [International journal]

    　View Summary

    OBJECTIVE: Transcranial electrical stimulation motor evoked potentials (TES-MEP) are widely used to monitor motor function; however, broad current spread and induced body movement are limitations of this technique. We herein report a localized stimulation technique for TES-MEP that induces unilateral MEP responses. METHODS: The stimulation of C1(+)-C4(-) or C2(+)-C3(-) was performed to induce right- or left-sided muscle contraction, respectively, in 70 patients. Electromyography was recorded by placing electrodes on the bilateral abductor pollicis brevis (APB) and abductor hallucis (AH) muscles. Stimulation conditions were regulated in the range to induce unilateral muscle contractions contralateral to the anodal stimulation. The thresholds and amplitudes of TES-MEP were retrospectively analyzed. RESULTS: The thresholds of APB were lower than those of AH in 47 patients, AH thresholds were lower than those of APB in 6 patients, and both APB and AH started to respond at the same intensity in 15 patients. This technical stimulation induced contralateral limb contractions with a suprathreshold stimulation of 129.4 ± 35.6 mA (mean ± standard deviation) in 68 patients (97%). Amplitudes in the suprathreshold stimulation of APB and AH responses were 727.5 ± 695.7 and 403.3 ± 325.7 μV, respectively. CONCLUSIONS: The C1(+)-C4/C2(+)-C3(-) stimulation in TES-MEP enables a localized stimulation to induce unilateral MEP responses. SIGNIFICANCE: Our stimulation technique enables the stable and safe monitoring of unilateral limbs, and contributes to the reliable monitoring of motor function in neurosurgery.

    DOI PubMed

  • Steady-State Cortico-Cortical Evoked Potential.

    Masayasu Arihara, Rei Enatsu, Satoko Ochi, Ayaka Sasagawa, Tsukasa Hirano, Tomoyoshi Kuribara, Shoto Yamada, Yusuke Kimura, Masao Matsuhashi, Nobuhiro Mikuni

    Journal of clinical neurophysiology : official publication of the American Electroencephalographic Society   40 ( 4 ) 301 - 309  2023.05  [International journal]

    　View Summary

    PURPOSE: The present study evaluated the utility of the steady-state responses of cortico-cortical evoked potentials (SSCCEPs) and compared them with the responses of conventional CCEPs. METHODS: Eleven patients with medically intractable focal epilepsy who underwent the implantation of subdural electrodes or stereoelectroencephalography were enrolled. Conventional CCEPs were obtained by averaging responses to alternating 1-Hz electrical stimuli, and 5-Hz stimuli were delivered for recording SSCCEPs. The distribution of SSCCEPs was assessed by a frequency analysis of fast Fourier transform and compared with conventional CCEPs. RESULTS: Steady-state responses of cortico-cortical evoked potentials were successfully recorded in areas consistent with conventional CCEPs in all patients. However, SSCCEPs were more easily disturbed by the 5-Hz stimulation, and small responses had difficulty generating SSCCEPs. CONCLUSIONS: Steady-state responses of cortico-cortical evoked potentials may be a useful alternative to conventional CCEPs.

    DOI PubMed

display all >>

To the head of this page.▲

Books and Other Publications 【 display / non-display 】

  • 術式と術前～術中～術後を見わたす 手術の見取り図

    小木曽 謙太( Part： Supervisor (editorial), ５．脳神経外科,)

    株式会社 照林社  2023

  • Clinical Neuroscience

    江夏 怜( Part： Contributor, 【脳波の読み方-up to date】特殊な脳波 皮質皮質間誘発電位(CCEP))

    中外医学社  2022

  • 合する合気の道 : 大東流合気柔術

    江夏, 怜

    ブイツーソリューション,星雲社 (発売)  2020.02 ISBN: 9784434270987

  • 機能的脳神経外科診療ガイドブック

    ( Part： Contributor, 検査の進歩：非侵襲的検査)

    株式会社メジカルビュー社  2018

  • 脳神経外科 臨床マニュアル改訂第５版

    江夏 怜( Part： Contributor, Ⅸ章 てんかん、不随意運動など. 49節てんかん焦点診断)

    丸善出版株式会社  2018

display all >>

To the head of this page.▲

Misc 【 display / non-display 】

  • 難治性てんかんに対して迷走神経刺激療法を導入した3例

    木村修平, 信田大喜子, 辻岡孝郎, 内田雅也, 上野倫彦, 白石秀明, 笹森徹, 寳金清博, 江夏怜, 越智さと子, 三國信啓, 佐野仁美

    日本小児科学会雑誌 ( (公社)日本小児科学会 )  121 ( 11 ) 1890 - 1890  2017.11

    J-GLOBAL

  • PCASに対する神経集中治療 軽度低体温施行症例における異常脳波所見

    宮田 圭, 喜屋武 玲子, 成松 英智, 江夏 怜, 三國 信啓, 臼井 桂子, 長峯 隆, 西田 絢一, 國分 宣明

    Neurosurgical Emergency ( (NPO)日本脳神経外科救急学会 )  20 ( 3 ) 445 - 445  2016.01

  • 焦点刺激による皮質-皮質間誘発電位(CCEP)を用いた発作伝播ネットワークの解明~6例の検討~

    菅野彩, 江夏怜, 越智さと子, 松橋眞生, 矢澤省吾, 長峯隆, 三國信啓

    日本てんかん外科学会プログラム・抄録集   39th  2015

    J-GLOBAL

  • Language Reorganization in Temporal Lobe Epilepsy: A Cortico-cortical Evoked Potential Study

    Rei Enatsu, Yuichi Kubota, Yosuke Kakisaka, Juan Bulacio, Zhe Piao, Timothy O'Connor, Karl Horning, John Mosher, Richard Burgess, William E. Bingaman, Dileep Nair

    NEUROSURGERY ( LIPPINCOTT WILLIAMS & WILKINS )  71 ( 2 ) E568 - E569  2012.08

    Research paper, summary (international conference)  

To the head of this page.▲

Awards 【 display / non-display 】

  • 平成27年度研究褒賞受賞

    2016.03   公益財団法人てんかん治療研究振興財団   皮質－皮質間誘発電位を用いた脳内ネットワーク研究

    Winner： 江夏 怜

  • Handa Hajime Prize

    2015.02   Kyoto Neurosurgery Camphor tree Forum   Connections of the limbic network: a corticocortical evoked potentials study

    Winner： 江夏 怜

  • 2014 Juhn and Mary Wada Prize

    2014.10   The Japan Epilepsy Society   Cortical negative motor network in comparison with sensorimotor network: a cortico-cortical evoked potential study.

    Winner： 江夏 怜

  • Best poster award in the Stereotactic and Functional Section

    2013.10   Congress of neurological surgeons 2013   Connections of the limbic network: a corticocortical evoked potentials study

  • Third place best poster award

    2013.05   81st AANS Annual Scientific Meeting   Posterior cingulate epilepsy: clinical and neurophysiological analysis

display all >>

To the head of this page.▲

Research Projects 【 display / non-display 】

  • 脳溝内の皮質機能の解明

    脳溝内の皮質機能の解明

    Project Year :

    2019
    -
    2021
     

    Authorship： Principal investigator

  • Expolaration of epileptic networks using cortico-cortical evoked potential

    Grant-in-Aid for Scientific Research (C)

    Project Year :

    2016.04
    -
    2019.03
     

    Enatsu Rei

    　View Summary

    The aim of this study is to explore the epileptic networks using cortico-cortical evoked potentials. We recorded the cortico-cortical evoked potentials in the stimulation of epileptogenic regions in 33 patients, and are analyzing the data. Furthermore, in association with this study, we have reported the networks of frontal aslant tract, basal temporal language areas, auditory cortex, and distribution of eloquent cortices and afterdischarges in the electrical cortical stimulation.

To the head of this page.▲

Presentations 【 display / non-display 】

  • Cortico-cortical evoked potentials: The Cleveland Clinic experience.

    Enatsu R  [Invited]

    11th European congress of epileptology 

    Event date：
    2014.06
    -
    2014.07

  • ブレインラボ手術支援ロボットアームCirqシステムを使用した深部電極留置.

    江夏 怜, 菅野 彩, 三國 信啓  [Invited]

    第55回日本てんかん学会学術集会 

    Event date：
    2022.09
    　
    　

  • てんかん外科治療における脳磁図と頭蓋内電極の⽐較

    江夏 怜, 菅野 彩, 白石 秀明, 三國 信啓  [Invited]

    第37回日本生体磁気学会大会 

    Event date：
    2022.06
    　
    　

  • てんかんにおける侵襲的モニタリングの基礎

    江夏 怜, 菅野 彩, 三國 信啓  [Invited]

    第42回日本脳神経外科コングレス総会 

    Event date：
    2022.05
    　
    　

  • 覚醒下のてんかん外科手術

    江夏 怜, 菅野 彩, 三國 信啓

    第31回脳神経外科と機器学会 

    Event date：
    2022.04
    　
    　

display all >>

To the head of this page.▲
 

Teaching Experience 【 display / non-display 】

  • 大学院生 脳機能講義  

    2015.04
    -
    Now
     

  • 機能的脳神経外科  

    2014.10
    -
    Now
     

  • 臨床入門  

    2014.10
    -
    Now
     

To the head of this page.▲
 

Committee Memberships 【 display / non-display 】

  • 2020.10
    -
    Now

      国際関連委員会委員、編集委員会委員、ガイドライン作成委員会委員

  • 2018.12
    -
    2020.12

      Epilepsy Surgery Education Task force

  • 2013.10
    -
    Now

      評議員、英文ジャーナル委員会委員、VNS・SEEG 資格認定委員会委員、移行期医療検討委員会委員

To the head of this page.▲