Education 【 display / non-display 】

Education 【 display / non-display 】

• 2003

  -

  2007

  Kyoto University, Graduate school of medicine  

• 1994

  -

  2000

  Kyushu University   School of Medicine   医学科  

Research Experience 【 display / non-display 】

Research Experience 【 display / non-display 】

• 2018.10

  -

  Now

  Sapporo Medical University   脳神経外科   講師

• 2014.10

  -

  2018.09

  Sapporo Medical University   脳神経外科   助教

• 2013.09

  -

  2014.09

  国立病院機構姫路医療センター   脳神経外科   医員

• 2012.08

  -

  2013.08

  Cleveland Clinic   Department of Neurosurgery   Clinical fellow

• 2008.09

  -

  2012.07

  Cleveland Clinic   Epilepsy center   Research fellow

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Professional Memberships 【 display / non-display 】

Professional Memberships 【 display / non-display 】

• 　

  　

  　

  日本生体磁気学会

• 　

  　

  　

  日本脳神経血管内治療学会

• 　

  　

  　

  日本脳卒中の外科学会

• 　

  　

  　

  International League Against Epilepsy

• 　

  　

  　

  日本脳神経外科学会

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Research Areas 【 display / non-display 】

Research Areas 【 display / non-display 】

• Life sciences   Neurosurgery  

• Life sciences   Nervous system function  

Affiliation 【 display / non-display 】

Affiliation 【 display / non-display 】

• Sapporo Medical University   脳神経外科  

Research Interests 【 display / non-display 】

Research Interests 【 display / non-display 】

• てんかん

• 不随意運動症

• 脳内ネットワーク

• 皮質-皮質間誘発電位

Papers 【 display / non-display 】

Papers 【 display / non-display 】

• Functional Brain Mapping Using Depth Electrodes

  Chie Kamada, Rei Enatsu, Seiichiro Imataka, Aya Kanno, Satoko Ochi, Nobuhiro Mikuni

  World Neurosurgery ( Elsevier BV )  188   e288 - e296  2024.08

  DOI

• An anatomo-functional study of the interactivity between the paracentral lobule and the primary motor cortex.

  Yusuke Kimura, Shoto Yamada, Katsuya Komatsu, Rei Enatsu, Ryota Sato, Chie Kamada, Ayaka Sasagawa, Tsukasa Hirano, Masayasu Arihara, Nobuhiro Mikuni

  Journal of neurosurgery     1 - 9  2024.05  [International journal]

  　View Summary

  OBJECTIVE: The purpose of this study was to understand the anatomical and functional connections between the paracentral lobule (PCL) and the primary motor cortex (M1) of the human brain. METHODS: This retrospective study included 16 patients who underwent resection of lesions located near M1. Nine patients had lesions in the dominant hemisphere. Tractography was performed to visualize the connectivity between two regions of interest (ROIs)-the convexity and the interhemispheric fissure-that were shown by functional MRI to be activated during a finger tapping task. The number, mean length, and fractional anisotropy (FA) of the fibers between the ROIs were estimated. During surgery, subdural electrodes were placed on the brain surface, including the ROIs, using a navigation system. Cortico-cortical evoked potentials (CCEPs) were evoked by applying electrical stimuli to the hand region of M1 using electrodes placed on the convexity and were measured with electrodes placed on the interhemispheric fissure. To verify CCEP bidirectionality, electrical stimuli were applied to electrodes on the interhemispheric fissure that showed CCEP responses. Correlations of CCEP amplitudes and latencies with the number, mean length, and mean FA value obtained from tractography were determined. The correlations between these parameters and perioperative motor functions were also analyzed. RESULTS: Fibers of 14 patients were visualized by diffusion tensor imaging (DTI). Unidirectional CCEPs between the PCL and M1 were measurable in all 16 patients, and bidirectional CCEPs between them were measurable in 14 patients. There was no significant difference between the two directions in the maximum CCEP amplitude or latency (amplitude, p = 0.391; latency, p = 0.583). Neither the amplitude nor latency showed any apparent correlation with the number, mean length, or mean FA value of the fibers obtained from tractography. Pre- and postoperative motor function of the hands was not significantly correlated with CCEP amplitude or latency. The number and mean FA value of fibers obtained by DTI, as well as the maximum CCEP amplitude, varied between patients. CONCLUSIONS: This study demonstrated an anatomical connection and a bidirectional functional connection between the PCL, including the supplementary motor area, and M1 of the human brain. The observed variability between patients suggests possible motor function plasticity. These findings may serve as a foundation for further studies.

  DOI PubMed

• 【臨床てんかん学における最新の話題】最新のてんかん外科治療

  江夏 怜

    40   36 - 45  2023.12  [Refereed]  [Invited]

• 【大脳白質解剖と脳内ネットワーク2024 脳機能と脳科学がみえる】大脳白質解剖・脳内ネットワークのTips 脳内ネットワーク解明とその歴史

  江夏 怜

  脳神経外科速報   33 ( 6 ) 770 - 771  2023.11  [Invited]

• Intraoperative nerve stimulation during vagal nerve stimulator placement

  Chie Kamada, Rei Enatsu, Aya Kanno, Satoko Ochi, Shoto Yamada, Ryota Sato, Ryohei Chiba, Nobuhiro Mikuni

  Surgical Neurology International ( Scientific Scholar )  14   312 - 312  2023.09

  　View Summary

  Background: Vagal nerve stimulation (VNS) is a palliative treatment for refractory epilepsy and intraoperative nerve stimulation is applied to the vagal and other nerves to prevent electrode misplacement. We evaluated these thresholds to establish intraoperative monitoring procedures for VNS surgery. Methods: Forty-six patients who underwent intraoperative nerve stimulation during VNS placement were enrolled. The vagal nerve and other exposed nerves were electrically stimulated during surgery, and muscle contraction was confirmed by electromyography of the vocal cords and visual recognition of cervical muscle contraction. The nerve thresholds and the most sensitive parts of the vagal nerve were analyzed retrospectively. Results: The stimulation of vagal nerves induced vocal cord responses in all 46 patients; the median thresholds of the most sensitive parts and all parts were 0.2 mA (range: 0.05–0.75 mA) and 0.25 mA (range: 0.15–1.5 mA), respectively. The medial middle region was identified as the most sensitive part of the vagal nerve in the majority of participants (82.5%). In 11 patients, other cervical nerves were stimulated and sternohyoid muscle contraction was induced with a median threshold of 0.35 mA (range: 0.1–0.7 mA) in eight patients, while sternocleidomastoid muscle contraction was induced with a median threshold of 0.2 mA (range: 0.1–0.2 mA) in three. Conclusion: Intraoperative stimulation of vagal nerves induces vocal cord responses with locational variations, and the middle part stimulation could minimize the stimulus intensities. The nerves innervating the sternohyoid and sternocleidomastoid muscles may be exposed during the procedure. Knowledge of these characteristics will enhance the effectiveness of this technique in future applications.

  DOI

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Books and Other Publications 【 display / non-display 】

Books and Other Publications 【 display / non-display 】

• すぐに役立つ脳神経外科救急ハンドブック 改訂3版：各種分類・スコア・スケールのダウンロードシート付き

  江夏 怜( Part： Contributor, ２．検査と診断 Ⅱその他の検査・診断 １脳波)

  メディカ出版  2024.09 ISBN: 4840485259

  ASIN

• 脳機能解明の歴史 意識の座はどこにある？

  江夏怜( Part： Sole author)

  日本橋出版  2024.04 ISBN: 4434338080

  ASIN

• 脳波超入門: 脳波判読の基礎からレポート、頭蓋内脳波まで／「読みどころ」が分かる解説動画付き！

  江夏 怜( Part： Sole author)

  メディカ出版  2024.01 ISBN: 4840484600

  ASIN

• 術式と術前～術中～術後を見わたす 手術の見取り図

  小木曽 謙太( Part： Supervisor (editorial), ５．脳神経外科,)

  株式会社 照林社  2023

• Clinical Neuroscience

  江夏 怜( Part： Contributor, 【脳波の読み方-up to date】特殊な脳波 皮質皮質間誘発電位(CCEP))

  中外医学社  2022

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Misc 【 display / non-display 】

Misc 【 display / non-display 】

• 日本武術の上肢立関節技における関節運動方向による分類

  江夏 怜

  武道学研究   54 ( 2 ) 141 - 148  2022.03  [Refereed]

• 特集序章 “気絶”を引き起こす！ 武術の技のメカニズム

  江夏 怜

  月刊秘伝2021年10月号     16 - 19  2021.10  [Invited]

• USMLE体験記—裏技と落とし穴

  江夏 怜

  脳神経外科   46 ( 12 ) 1121 - 1125  2018.12  [Refereed]

• 難治性てんかんに対して迷走神経刺激療法を導入した3例

  木村修平, 信田大喜子, 辻岡孝郎, 内田雅也, 上野倫彦, 白石秀明, 笹森徹, 寳金清博, 江夏怜, 越智さと子, 三國信啓, 佐野仁美

  日本小児科学会雑誌 ( (公社)日本小児科学会 )  121 ( 11 ) 1890 - 1890  2017.11

  J-GLOBAL

• PCASに対する神経集中治療 軽度低体温施行症例における異常脳波所見

  宮田 圭, 喜屋武 玲子, 成松 英智, 江夏 怜, 三國 信啓, 臼井 桂子, 長峯 隆, 西田 絢一, 國分 宣明

  Neurosurgical Emergency ( (NPO)日本脳神経外科救急学会 )  20 ( 3 ) 445 - 445  2016.01

Awards 【 display / non-display 】

Awards 【 display / non-display 】

• 平成27年度研究褒賞受賞

  2016.03   公益財団法人てんかん治療研究振興財団   皮質－皮質間誘発電位を用いた脳内ネットワーク研究

  Winner： 江夏 怜

• Handa Hajime Prize

  2015.02   Kyoto Neurosurgery Camphor tree Forum   Connections of the limbic network: a corticocortical evoked potentials study

  Winner： 江夏 怜

• 2014 Juhn and Mary Wada Prize

  2014.10   The Japan Epilepsy Society   Cortical negative motor network in comparison with sensorimotor network: a cortico-cortical evoked potential study.

  Winner： 江夏 怜

• Best poster award in the Stereotactic and Functional Section

  2013.10   Congress of neurological surgeons 2013   Connections of the limbic network: a corticocortical evoked potentials study

• Third place best poster award

  2013.05   81st AANS Annual Scientific Meeting   Posterior cingulate epilepsy: clinical and neurophysiological analysis

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Research Projects 【 display / non-display 】

Research Projects 【 display / non-display 】

• 脳溝内の皮質機能の解明

  脳溝内の皮質機能の解明

  Project Year :

  2019

  -

  2021

   

  Authorship： Principal investigator

• Expolaration of epileptic networks using cortico-cortical evoked potential

  Grant-in-Aid for Scientific Research (C)

  Project Year :

  2016.04

  -

  2019.03

   

  Enatsu Rei

  　View Summary

  The aim of this study is to explore the epileptic networks using cortico-cortical evoked potentials. We recorded the cortico-cortical evoked potentials in the stimulation of epileptogenic regions in 33 patients, and are analyzing the data. Furthermore, in association with this study, we have reported the networks of frontal aslant tract, basal temporal language areas, auditory cortex, and distribution of eloquent cortices and afterdischarges in the electrical cortical stimulation.

Presentations 【 display / non-display 】

Presentations 【 display / non-display 】

• Cortico-cortical evoked potentials: The Cleveland Clinic experience.

  Enatsu R  [Invited]

  11th European congress of epileptology 

  Event date：

  2014.06

  -

  2014.07

• Functional brain mapping with depth electrodes

  Rei Enatsu, Chie Kamada, Aya Kanno, Satoko Ochi, Nobuhiro Mikuni

  American Epilepsy Society, 2023 annual meeting: 2023 Dec 1- 5: Orland, USA 

  Presentation date： 2024.12

  Event date：

  2024.12

  　

  　

• SEEG-伝統的手法と実用の工夫

  江夏 怜  [Invited]

  Presentation date： 2023.12

  Event date：

  2023.11

  -

  2023.12

• 江夏 怜、三國 信啓, 皮質-皮質間誘発電位(CCEP)とてんかん病態

  江夏怜  [Invited]

  日本脳神経外科学会第82回学術総会、2023年10月25-27日、横浜 

  Presentation date： 2023.10

  Event date：

  2023.10

  　

  　

• ブレインラボ手術支援ロボットアームCirqシステムを使用した深部電極留置.

  江夏 怜, 菅野 彩, 三國 信啓  [Invited]

  第55回日本てんかん学会学術集会 

  Event date：

  2022.09

  　

  　

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Teaching Experience 【 display / non-display 】

Teaching Experience 【 display / non-display 】

• 大学院生 脳機能講義  

  2015.04

  -

  Now

   

• 機能的脳神経外科  

  2014.10

  -

  Now

   

• 臨床入門  

  2014.10

  -

  Now

   

Committee Memberships 【 display / non-display 】

Committee Memberships 【 display / non-display 】

• 2020.10

  -

  Now

    評議員、国際関連委員会委員、編集委員会委員、ガイドライン作成委員会委員

• 2018.12

  -

  2020.12

    Epilepsy Surgery Education Task force

• 2013.10

  -

  Now

    評議員、英文ジャーナル委員会委員、デバイス等技術資格認定委員会委員、移行期医療検討委員会委員

• 　

  　

  　

    NMC査読委員