研究者詳細 - 津川　毅

論文 - 津川　毅

分割表示 91 件中 21 - 40 件目／全件表示 >>

Risks and prevention of severe respiratory syncytial virus infection among infants and children with pulmonary hypoplasia, airway stenosis, congenital esophageal atresia, inborn errors of metabolism, or neuromuscular diseases in Japan.

Masaaki Mori, Yoshinori Ito, Naruhiko Ishiwada, Kenta Ito, Masayoshi Shinjoh, Takeshi Tsugawa, Takanori Funaki, Munehiro Furuichi, Tadashi Hoshino, Isao Miyairi, Takuya Kondo, Akinari Hinoki, Motoshi Wada, Kuniyuki Okada, Seigo Korematsu, Naoyuki Tanuma, Hisaya Hasegawa, Kenichiro Hosoi, Kanako Yoshizaki, Mika Ishige

Journal of infection and chemotherapy : official journal of the Japan Society of Chemotherapy 31 ( 3 ) 102588 - 102588 2025年03月 [国際誌]

BACKGROUND: In March 2024, children with pulmonary hypoplasia, airway stenosis, congenital esophageal atresia, inborn errors of metabolism, and neuromuscular diseases became eligible for palivizumab in Japan. Despite limited epidemiological data, expert consensus guided the recommendation for palivizumab use in these children to ensure its proper application. OBJECTIVES: This article outlines the proper use of palivizumab for RSV infection in infants and children with the specified conditions, aiming to enhance understanding of the medical basis for its clinical guidance. METHODS: A nationwide survey targeted pediatric specialist facilities. Additionally, an investigator-initiated clinical trial under AMED evaluated palivizumab's efficacy and safety in newborns, infants, and young children with the five high-risk diseases. RESULTS: Palivizumab was given to 23 children aged 24 months or younger with the specified conditions. No RSV-related hospitalizations occurred, and serum concentrations remained therapeutically effective. Adverse events were consistent with existing data, with no serious events linked to palivizumab. CONCLUSION: Following successful trial results, early approval was granted on March 26, 2024. This article aims to promote the appropriate use of palivizumab for RSV infection in children with the specified conditions through clinical guidance.

DOI PubMed

Molecular Evolutionary Analyses of the RNA-Dependent RNA Polymerase (RdRp) Region and VP1 Gene in Sapovirus GI.1 and GI.2.

Fuminori Mizukoshi, Ryusuke Kimura, Tatsuya Shirai, Asumi Hirata-Saito, Eri Hiraishi, Kosuke Murakami, Yen Hai Doan, Hiroyuki Tsukagoshi, Nobuhiro Saruki, Takeshi Tsugawa, Kana Kidera, Yoshiyuki Suzuki, Naomi Sakon, Kazuhiko Katayama, Tsutomu Kageyama, Akihide Ryo, Hirokazu Kimura

Microorganisms 13 ( 2 ) 2025年02月 [国際誌]

Human sapovirus (HuSaV) is a significant cause of gastroenteritis. This study aims to analyze the evolutionary dynamics of the RNA-dependent RNA polymerase (RdRp) and capsid (VP1) genes of the HuSaV GI.1 and GI.2 genotypes between 1976 and 2020. Using bioinformatics tools such as the Bayesian phylogenetics software BEAST 2 package (v.2.7.6), we constructed time-scale evolutionary trees based on the gene sequences. Most of the recent common ancestors (MRCAs) of the RdRp region and VP1 gene in the present HuSaV GI.1 diverged around 1930 and 1933, respectively. The trees of the HuSaV GI.1 RdRp region and VP1 gene were divided into two clusters. Further, the MRCAs of the RdRp region and VP1 gene in HuSaV GI.2 diverged in 1960 and 1943, respectively. The evolutionary rates were higher for VP1 gene in HuSaV GI.1 than that in HuSaV GI.2, furthermore, were higher in GI.1 Cluster B than GI.1 Cluster A. In addition, a steep increase was observed in the time-scaled genome population size of the HuSaV GI.1 Cluster B. These results indicate that the HuSaV GI.1 Cluster B may be evolving more actively than other genotypes. The conformational B-cell epitopes were predicted with a higher probability in RdRp for GI.1 and in VP1 for GI.2, respectively. These results suggest that the RdRp region and VP1 gene in HuSaV GI.1 and GI.2 evolved uniquely. These findings suggest unique evolutionary patterns in the RdRp region and VP1 gene of HuSaV GI.1 and GI.2, emphasizing the need for a 'One Health' approach to better understand and combat this pathogen.

DOI PubMed

Ulcerative Colitis Preceding Asymptomatic Wilson's Disease: A Case Report and Literature Review.

Jun Kunizaki, Yuko Yoto, Yoshinobu Nagaoka, Akira Ishii, Tomoe Kazama, Kohei Wagatsuma, Noriyuki Akutsu, Aki Ishikawa, Toju Tanaka, Shintaro Sugita, Takeshi Tsugawa, Hiroshi Nakase

Gastro hep advances ( Elsevier BV ) 4 ( 1 ) 100548 - 100548 2025年 [国際誌]

An 11-year-old girl with quiescent ulcerative colitis had sustained elevation of liver enzymes. Although she had no clinical symptoms suggestive of Wilson's disease, such as Kayser-Fleischer rings, laboratory data showed decreased serum copper and ceruloplasmin levels and increased urinary copper excretion. Genetic testing showed pathogenic variants in ATP7B allele 1: c.2004_2006delGAT (p. Met668del) and allele 2: c.1708-5T>G. After starting copper chelators, her liver function normalized, and she maintained clinical and endoscopic remission of ulcerative colitis. Mutations or defective functions of ATP7B lead to hepatic dysfunction and intestinal inflammation.

DOI PubMed

Successful treatment of pediatric mature B-cell lymphoma with MYC and BCL6 rearrangements.

Ryo Hamada, Masaki Yamamoto, Yusuke Akane, Keita Igarashi, Takeshi Tsugawa

Pediatrics international : official journal of the Japan Pediatric Society 67 ( 1 ) e70037 2025年 [国際誌]

DOI PubMed

Review of the past and present status of respiratory syncytial virus and rotavirus infections that commonly affect children.

Hiroyuki Tsutsumi, Takeshi Tsugawa

Journal of infection and chemotherapy : official journal of the Japan Society of Chemotherapy 30 ( 9 ) 825 - 831 2024年09月 [査読有り] [国際誌]

Respiratory syncytial virus (RSV) and rotavirus infections are long-standing infectious diseases that affect children worldwide. RSV and rotavirus were first discovered in clinical specimens in 1955 and 1973, respectively. From their discovery to the present day, significant progress has been made in understanding these two infections. The introduction of a simple and rapid antigen diagnostic test into clinical settings in the 1990s offered new insight into the clinical characteristics and epidemiology of these infections. Regarding therapeutics, symptomatic treatments have remained the mainstay; however, prophylactic humanized anti-RSV monoclonal antibodies have been developed and advances in structural biology may allow for more effective human anti-RSV monoclonal antibodies and novel RSV vaccines to be developed soon. For rotavirus, two vaccines have been licensed and broadly applied over the past 10 years, which have been successful clinically and have changed the epidemiology of rotavirus infections in Japan.

DOI PubMed

Crizotinib therapy for congenital embryonal rhabdomyosarcoma associated with an ATIC-ALK gene fusion.

Yusuke Akane, Masaki Yamamoto, Akira Takebayashi, Ryo Hamada, Keita Igarashi, Makoto Emori, Shintaro Sugita, Kohichi Takada, Tadashi Hasegawa, Takeshi Tsugawa

Pediatric blood & cancer 71 ( 9 ) e31148 2024年09月 [査読有り] [国際誌]

担当区分：最終著者

DOI PubMed

「データベースを用いた国内発症小児Coronavirus Disease 2019(COVID-19)症例の臨床経過に関する検討」最終報告

勝田友博, 天羽清子, 荒木かほる, 石和田稔彦, 大宜見力, 大城誠, 神谷元, 越田理恵, 清水直樹, 高野智子, 津川毅, 富樫篤生, 中野貴司, 西村直子, 野崎昌俊, 菱木はるか, 藤岡雅司, 保科隆之, 細矢光亮, 前田明彦, 水野由美, 宮崎雅仁, 吉川哲史, 和田泰三, 岩田敏, 尾内一信, 岡田賢司, 是松聖悟, 菅秀, 宮崎千明, 森内浩幸, 齋藤昭彦, 塚原宏一, 森岡一朗, 宮入烈, 多屋馨子, 日本小児科学会予防接種・感染症対策委員会

日本小児科学会雑誌 ( (公社)日本小児科学会 ) 128 ( 5 ) 777 - 783 2024年05月

「データベースを用いた国内発症小児Coronavirus Disease 2019(COVID-19)症例の臨床経過に関する検討」最終報告

日本小児科学会雑誌 ( (公社)日本小児科学会 ) 128 ( 5 ) 777 - 783 2024年05月

専用データベースに日本小児科学会会員により任意で報告された臨床情報を用いて、2020年2月～2022年9月に発症した16歳未満の国内小児COVID-19患者10007例(男児5413例、女児4594例、年齢中央値6.1歳)の臨床的特徴を解析した。発症時期は、オミクロン株流行前が42.1%、オミクロン流行後が57.9%であった。オミクロン株流行前と比較して流行後は、初診時において37.5℃以上の発熱、乾性咳嗽、犬吠様咳嗽、喉頭痛、喘鳴、倦怠感、筋肉痛、関節痛、頭痛、痙攣、腹痛、悪心・嘔吐を認める割合が有意に増加した。慢性期症状の有無が追加報告された4669例中187例(4.0%)で発症後1ヵ月以降に何らかの症状が報告され、主な慢性期症状は発熱1.2%、咳嗽1.2%、嗅覚障害0.7%、味覚障害0.7%、倦怠感0.6%などであった。

Children's cognition and attitudes during long-term cancer treatment: an ethnographic study.

Ryoko Michinobu, Masaki Yamamoto, Keita Igarashi, Yoshiyuki Sakai, Yusuke Akane, Dai Yamamoto, Akira Takebayashi, Takahiro Mikami, Hiroyuki Tsutsumi, Takeshi Tsugawa

BMJ paediatrics open 8 ( 1 ) 2024年04月 [査読有り] [国際誌]

担当区分：最終著者

BACKGROUND: Cancer treatment for children is typically long-term and difficult, and the experience is unique for each child. When designing child-centred care, individuals' values and preferences are considered equally important as the clinical evidence; therefore, understanding children's thoughts and attitudes while they receive long-term treatment could offer valuable insights for better clinical practice. METHODS: We conducted long-term consecutive participatory observations and interviews with seven children, who were hospitalised and receiving cancer treatment for the first time. The daily observational data on those children's discourses, behaviours and interactions with health professionals were systematically collected and thematically examined. The analysis was expanded to explore significant narratives for each child to capture their narrative sequence over time. RESULTS: The initial analysis identified 685 narrative indexes for all observation data, which were categorised into 21 sub-codes. Those sub-codes were assembled into five main themes by thematic analysis: making promises with health professionals, learning about the treatment procedures through participation, taking care of oneself, increasing the range of activities one can perform and living an ordinary life. CONCLUSION: We observed a forward-looking attitude toward understanding cancer, accepting treatment and looking forward to the future among children undergoing in-hospital cancer treatment. In addition, the children developed cognitively, affectively and relationally throughout cancer treatment processes. These findings have implications for better clinical practice in child-centred care, including children's participation in shared decision-making in paediatric oncology.

DOI PubMed

「原因不明の小児急性肝炎に関する実態調査(二次調査)」報告

近藤宏樹, 多屋馨子, 天羽清子, 乾あやの, 笠原群生, 鈴木光幸, 田中孝明, 津川毅, 別所一彦, 保科隆之, 宮入烈, 虫明聡太郎, 吉川哲史, 齋藤昭彦, 塚原宏一, 森岡一朗, 須磨崎亮, 細矢光亮, 日本小児科学会予防接種・感染症対策委員会原因不明の小児の急性肝炎対策ワーキンググループ

日本小児科学会雑誌 ( (公社)日本小児科学会 ) 128 ( 4 ) 668 - 680 2024年04月

Severe cervical abscess due to PVL-positive ST6562 MRSA-IVa, a presumptive variant of ST8-IVa USA300 clone in northern Japan.

Katsumasa Kudo, Takahiro Noda, Yuta Sasaoka, Atsuo Togashi, Meiji Soe Aung, Yoshiyuki Sakai, Takeshi Tsugawa, Nobumichi Kobayashi

New microbes and new infections 58 101230 - 101230 2024年04月 [査読有り] [国際誌]

DOI PubMed

Effects of probiotics in children with acute gastroenteritis: A systematic review and meta-analysis focusing on probiotics utilized in Japan.

Toru Higuchi, Munehiro Furuichi, Naonori Maeda, Takeshi Tsugawa, Kenta Ito

Journal of infection and chemotherapy : official journal of the Japan Society of Chemotherapy 30 ( 4 ) 337 - 342 2024年04月 [査読有り] [国際誌]

BACKGROUND: Many randomized controlled trials and systematic reviews have evaluated the use of probiotics to treat acute infectious gastroenteritis. However, most probiotic species evaluated in previous large randomized controlled trials are unavailable in Japan. Our objective was to investigate the efficacy of probiotics utilized in Japan for acute gastroenteritis. METHODS: The inclusion criterion was a randomized controlled study that compared probiotics with a placebo to treat children younger than 18 years with acute infectious gastroenteritis. We excluded studies that did not contain the following species available in Japan: Bifidobacterium spp., Lactobacillus acidophilus, Enterococcus faecium, Clostridium butyricum, and Bacillus subtilis and studies in low- or lower-middle-income countries. We searched PubMed, CENTRAL, and Igaku Chuo Zasshi from their inception to November 27, 2022. After the risk of bias assessment, data on diarrhea duration, number of hospitalizations, length of hospital stay, and adverse effects were extracted. RESULTS: Fourteen studies were included in this meta-analysis. Diarrhea lasting longer than 48 h (7 articles, n = 878) was significantly lower in the probiotic group (risk ratio (RR) 0.70, 95 % confidence interval (CI) 0.59-0.83). The duration of diarrhea (14 articles; n = 1761) was 23.45 h (95 % CI 18.22-26.69) shorter in the probiotic group. Duration of hospitalization (6 articles; n = 971) was 17.73 h (95 % CI 6.9-28.56) shorter in the probiotic group. CONCLUSIONS: Although the certainty of evidence is very low, the use of probiotics for acute gastroenteritis in children may improve diarrhea approximately one day earlier. This study was registered with PROSPERO (CRD 42023405559).

DOI PubMed

COVID-19パンデミック期の小児の急性肝炎原因不明の小児急性肝炎対策ワーキンググループのこれまでの活動と調査結果に関する報告

近藤宏樹, 多屋馨子, 天羽清子, 乾あやの, 笠原群生, 齋藤昭彦, 鈴木光幸, 田中孝明, 塚原宏一, 津川毅, 別所一彦, 保科隆之, 宮入烈, 森岡一朗, 吉川哲史, 虫明聡太郎, 須磨崎亮, 細矢光亮

日本小児科学会雑誌 ( (公社)日本小児科学会 ) 128 ( 2 ) 165 - 165 2024年02月

おたふくかぜワクチン接種後の副反応に関する全国調査報告

神谷元, 西藤成雄, 中野貴司, 菅秀, 奥山舞, 田中敏博, 中村豊, 森野紗衣子, 高梨さやか, 新井智, 木所稔, 岡田賢司, 天羽清子, 荒木かほる, 石和田稔彦, 大宜見力, 勝田友博, 越田理恵, 高野智子, 津川毅, 富樫篤生, 西村直子, 野崎昌俊, 菱木はるか, 保科隆之, 細矢光亮, 前田明彦, 水野由美, 宮崎雅仁, 吉川哲史, 和田泰三, 岩田敏, 尾内一信, 是松聖悟, 清水直樹, 森内浩幸, 宮崎千明, 宮入烈, 森岡一朗, 塚原宏一, 齋藤昭彦, 多屋馨子, 日本小児科学会予防接種・感染症対策委員会

日本小児科学会雑誌 ( (公社)日本小児科学会 ) 128 ( 1 ) 92 - 104 2024年01月

2020年1月から2023年3月までに1歳以上就学前の小児に対して乾燥弱毒生おたふくかぜワクチン(おたふくかぜワクチン)接種を行った医師を対象に、接種8週間後までの副反応が疑われる症状に関して情報収集を行った。8週間フォローできた58783例における無菌性髄膜炎(8例)・急性脳炎(1例)・髄膜脳炎(1例)・無菌性髄膜炎疑い(2例)の発生報告頻度は0.020%であり、前向きに8週間フォローできた44708例では無菌性髄膜炎(疑い2例を含む)6例の発生報告頻度は0.013%であった。頻度は低いものの、おたふくかぜワクチン株が検出された症例で急性脳炎やけいれん重積を認めた症例があったこと、1回目接種後に髄膜炎を疑う症状が一定の頻度で発生していたこと、無菌性髄膜炎6例(疑いを含む)のうち5例が1回目接種後に発生していたことなどが報告された。

Trauma-related thyroid storm in adolescents: A case report.

Atsushi Jinno, Naofumi Bunya, Junya Hagiwara, Kai Takao, Keigo Sawamoto, Akira Ishii, Takeshi Tsugawa, Eichi Narimatsu, Yoshihisa Tsuji

Acute medicine & surgery 11 ( 1 ) e70004 2024年 [国際誌]

BACKGROUND: Because of a scant report, it is little known that thyroid storms can occur after trauma, even in adolescence. Significantly, this increases the risk of delaying diagnosis resulting in life-threatening. CASE PRESENTATION: A 13-year-old girl was admitted to the emergency department after a traffic accident. Despite receiving comprehensive trauma care, the patient developed hyperthermia and tachycardia that did not respond to temperature management therapy. On the 10th day of her admission, she was diagnosed with a thyroid storm. Treatment for thyroid storm was initiated; thereby, her condition was totally improved. CONCLUSION: We experienced a case of an adolescent girl, who developed a thyroid storm during the treatment of trauma and could save her life. Clinicians should consider thyroid storm in post-traumatic hyperthermia and tachycardia patients, even in children.

DOI PubMed

Therapeutic efficacy of intravenous infusion of mesenchymal stem cells in rat perinatal brain injury.

Kojiro Terada, Masanori Sasaki, Hiroshi Nagahama, Yuko Kataoka-Sasaki, Shinichi Oka, Ryo Ukai, Takahiro Yokoyama, Yusuke Iizuka, Takuro Sakai, Shinobu Fukumura, Takeshi Tsugawa, Jeffery D Kocsis, Osamu Honmou

Pediatric research 94 ( 6 ) 1921 - 1928 2023年12月 [査読有り] [国際誌]

BACKGROUND: Perinatal brain injury is multifactorial and primarily associated with brain prematurity, inflammation, and hypoxia-ischemia. Although recent advances in perinatal medicine have improved the survival rates of preterm infants, neurodevelopmental disorders remain a significant complication. We tested whether the intravenous infusion of mesenchymal stem cells (MSCs) had therapeutic efficacy against perinatal brain injury in rats. METHODS: Pregnant rats at embryonic day (E) 18 received lipopolysaccharide and the pups were born at E21. On postnatal day (PND) 7, the left common carotid artery of each pup was ligated, and they were exposed to 8% oxygen for 2 h. They were randomized on PND10, and MSCs or vehicle were intravenously infused. We performed behavioral assessments, measured brain volume using MRI, and performed histological analyses on PND49. RESULTS: Infused MSCs showed functional improvements in our model. In vivo MRI revealed that MSC infusion increased non-ischemic brain volume compared to the vehicle group. Histological analyses showed that cortical thickness, the number of NeuN+ and GAD67+ cells, and synaptophysin density in the non-ischemic hemisphere in the MSC group were greater than the vehicle group, but less than the control group. CONCLUSIONS: Infused MSCs improve sensorimotor and cognitive functions in perinatal brain injury and enhance neuronal growth. IMPACT: Intravenous infusion of MSCs improved neurological function in rats with perinatal brain injury, including motor, sensorimotor, cognitive, spatial, and learning memory. Infused MSCs increased residual (non-ischemic) tissue volume, number of neuronal cells, GABAergic cells, and cortical synapses in the contralesional (right) hemisphere. Intravenous administration of MSC might be suitable for the treatment of perinatal brain injury.

DOI PubMed

Changing Patterns of Infectious Diseases Among Hospitalized Children in Hokkaido, Japan, in the Post-COVID-19 Era, July 2019 to June 2022.

Yuya Fukuda, Atsuo Togashi, Satoshi Hirakawa, Masaki Yamamoto, Shinobu Fukumura, Tomohiro Nawa, Saho Honjo, Jun Kunizaki, Kouhei Nishino, Toju Tanaka, Toshitaka Kizawa, Dai Yamamoto, Ryoh Takeuchi, Yuta Sasaoka, Masayoshi Kikuchi, Takuro Ito, Kazushige Nagai, Hirofumi Asakura, Katsumasa Kudou, Masaki Yoshida, Takeshi Nishida, Takeshi Tsugawa

The Pediatric infectious disease journal 42 ( 9 ) 766 - 773 2023年09月 [査読有り] [国際誌]

担当区分：最終著者

BACKGROUND: Many reports have reported a reduction in respiratory infectious diseases and infectious gastroenteritis immediately after the coronavirus disease 2019 (COVID-19) pandemic, but data continuing into 2022 are very limited. We sought to understand the current situation of various infectious diseases among children in Japan as of July 2022 to improve public health in the post-COVID-19 era. METHODS: We collected data on children hospitalized with infectious diseases in 18 hospitals in Japan from July 2019 to June 2022. RESULTS: In total, 3417 patients were hospitalized during the study period. Respiratory syncytial virus decreased drastically after COVID-19 spread in early 2020, and few patients were hospitalized for it from April 2020 to March 2021. However, an unexpected out-of-season re-emergence of respiratory syncytial virus was observed in August 2021 (50 patients per week), particularly prominent among older children 3-6 years old. A large epidemic of delayed norovirus gastroenteritis was observed in April 2021, suggesting that the nonpharmaceutical interventions for COVID-19 are less effective against norovirus. However, influenza, human metapneumovirus, Mycoplasma pneumoniae , and rotavirus gastroenteritis were rarely seen for more than 2 years. CONCLUSIONS: The incidence patterns of various infectious diseases in Japan have changed markedly since the beginning of the COVID-19 pandemic to the present. The epidemic pattern in the post-COVID-19 era is unpredictable and will require continued careful surveillance.

DOI PubMed

Acute osteomyelitis/septic pulmonary embolism associated with familial infections caused by PVL-positive ST6562 MRSA-IVa, a presumptive variant of USA300 clone.

Nao Harada, Atsuo Togashi, Meiji Soe Aung, Jun Kunizaki, Kazutaka Nogami, Yoshinobu Nagaoka, Akira Ishii, Ima Kosukegawa, Wakiko Aisaka, Satoshi Nakamura, Tomohiro Wakabayashi, Takeshi Tsugawa, Nobumichi Kobayashi

IJID regions 8 16 - 18 2023年09月 [査読有り] [国際誌]

Panton-Valentine leukocidin (PVL)-positive methicillin-resistant Staphylococcus aureus (MRSA) occasionally causes severe invasive infections. A 10-year-old immunocompetent boy in Hokkaido, the northern main island of Japan, was admitted with acute osteomyelitis of the right ilium, complicated by septic thrombophlebitis of the right common iliac vein and septic pulmonary embolism. As MRSA was isolated from blood and sputum samples of the patient, linezolid and vancomycin were initially used for treatment, and later clindamycin was added based on PCR-positive results for PVL genes. During his hospitalization, the patient was complicated by abscesses around the right ilium and septic arthritis of the right hip, which required surgical drainage. Prior to his admission, his youngest sister had developed a right breast abscess, and another sister and his mother developed contagious impetigo and hordeolum, respectively, during his hospitalization. These infections in the patient and his family members were caused by an identical PVL-positive MRSA strain belonging to ST6562, a single-locus variant of ST8. Due to the genetically close characteristics, this ST6562 MRSA was considered a genetic variant of the USA300 CA-MRSA clone (ST8-MRSA-IVa) predominating in the United States. The ST6562 MRSA-IVa is suggested to have occurred in Japan, associated with potential spread of the USA300 clone.

DOI PubMed

Rivaroxaban for severe superior sagittal sinus thrombosis in a child with ALL.

Masaki Yamamoto, Yusuke Akane, Ryo Hamada, Hiroyuki Kabutoya, Keita Igarashi, Sangnyon Kim, Takeshi Tsugawa

International journal of hematology 118 ( 3 ) 309 - 310 2023年09月 [査読有り] [国内誌]

担当区分：最終著者

DOI PubMed

原因不明の小児急性肝炎に関する実態調査(一次調査)報告書

日本小児科学会雑誌 ( (公社)日本小児科学会 ) 127 ( 7 ) 1033 - 1038 2023年07月

　前のページ - 次のページ　

<津川 毅>

論文 - 津川 毅

<津川　毅>

論文 - 津川　毅