YAMANO hiroo

写真a

Affiliation

School of Medicine, Department of Gastroenterology

Job title

Associate Professor

Profile

 １９８９年 ３月 札幌医科大学医学部卒業
１９８９年 ４月 札幌医科大学第１内科入局
１９９０年 ４月 北海道社会事業協会小樽病院内科
１９９４年 ４月 札幌医科大学第１内科医員、同 付属病院
１９９４年１０月 秋田赤十字病院 胃腸センターにて研修
１９９６年１０月 秋田赤十字病院 胃腸センター 医員
２０００年１０月 同 副部長
２００２年 ７月 秋田赤十字病院 消化器病センター 消化器内科第２部長
２０１３年 ２月 秋田赤十字病院 消化器病センター長
２０１４年１２月 博士（医学）取得
２０１６年１１月 札幌医科大学医学部消化器内科学講座 准教授
２０１７年 １月 同 付属病院消化器内視鏡センター センター長
現在に至る

所属学会：日本消化器内視鏡学会、日本消化器病学会、日本内科学会、日本癌学会
日本臨床腫瘍学会、日本大腸肛門病学会、日本消化管学会、日本大腸検査学会、
日本消化管Virtual Reality学会

日本消化器内視鏡学会認定医
日本消化器内視鏡学会認定専門医・指導医・社団評議員
日本消化器病学会認定専門医
日本内科学会認定医、認定教育施設指導医
日本消化管学会暫定専門医、指導医
日本赤十字社 臨床研修指導医

日本消化器内視鏡学会北海道支部 評議員・同 幹事、同 セミナー委員(H28.11〜)
日本消化器病学会北海道支部 評議員(H28.11〜)
日本大腸検査学会 評議員
日本消化管Virtual Reality学会 理事長（2018.01〜）

聖マリアンナ医科大学 内科学(消化器・肝臓内科)非常勤講師 (2015/4/1〜)
秋田赤十字病院 消化器病センター 顧問（非常勤2016/11〜）

雑誌「胃と腸」,「INTESTINE」編集委員
早期胃癌研究会運営委員・運営幹事・運営委員長
臨床消化器病研究会（消化管の部）世話人
大腸癌研究会 世話人
拡大内視鏡研究会 世話人
大腸IIｃ研究会 世話人
東北消化管臨床･病理研究会 世話人
EMR/ESD研究会 世話人
北海道腸疾患研究会 世話人
北海道地区消化器内視鏡懇談会 世話人
大腸内視鏡アカデミーin北海道 代表世話人 他
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Professional Memberships 【 display / non-display 】

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    THE JAPANESE SOCIETY OF INTERNAL MEDICINE

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    日本消化管学会

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    JAPANESE SOCIETY OF GASTROENTEROLOGY

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    日本大腸検査学会

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    大腸癌研究会

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Affiliation 【 display / non-display 】

  • Sapporo Medical University   消化器内科学講座  

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Research Interests 【 display / non-display 】

  • 消化管癌

  • 内視鏡治療

  • 大腸癌

  • 内視鏡診断

  • 消化管腫瘍

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Papers 【 display / non-display 】

  • Narrow-band imaging (NBI) magnifying endoscopic classification of colorectal tumors proposed by the Japan NBI Expert Team

    Yasushi Sano, Shinji Tanaka, Shin-ei Kudo, Shoichi Saito, Takahisa Matsuda, Yoshiki Wada, Takahiro Fujii, Hiroaki Ikematsu, Toshio Uraoka, Nozomu Kobayashi, Hisashi Nakamura, Kinichi Hotta, Takahiro Horimatsu, Naoto Sakamoto, Kuang-I Fu, Osamu Tsuruta, Hiroshi Kawano, Hiroshi Kashida, Yoji Takeuchi, Hirohisa Machida, Toshihiro Kusaka, Naohisa Yoshida, Ichiro Hirata, Takeshi Terai, Hiro-o Yamano, Kazuhiro Kaneko, Takeshi Nakajima, Taku Sakamoto, Yuichiro Yamaguchi, Naoto Tamai, Naoko Nakano, Nana Hayashi, Shiro Oka, Mineo Iwatate, Hideki Ishikawa, Yoshitaka Murakami, Shigeaki Yoshida, Yutaka Saito

    DIGESTIVE ENDOSCOPY ( WILEY-BLACKWELL )  28 ( 5 ) 526 - 533  2016.07  [Refereed]

    　View Summary

    Many clinical studies on narrow-band imaging (NBI) magnifying endoscopy classifications advocated so far in Japan (Sano, Hiroshima, Showa, and Jikei classifications) have reported the usefulness of NBI magnifying endoscopy for qualitative and quantitative diagnosis of colorectal lesions. However, discussions at professional meetings have raised issues such as: (i) the presence of multiple terms for the same or similar findings; (ii) the necessity of including surface patterns in magnifying endoscopic classifications; and (iii) differences in the NBI findings in elevated and superficial lesions. To resolve these problems, the Japan NBI Expert Team (JNET) was constituted with the aim of establishing a universal NBI magnifying endoscopic classification for colorectal tumors (JNET classification) in 2011. Consensus was reached on this classification using the modified Delphi method, and this classification was proposed in June 2014. The JNET classification consists of four categories of vessel and surface pattern (i.e. Types 1, 2A, 2B, and 3). Types 1, 2A, 2B, and 3 are correlated with the histopathological findings of hyperplastic polyp/sessile serrated polyp (SSP), low-grade intramucosal neoplasia, high-grade intramucosal neoplasia/shallow submucosal invasive cancer, and deep submucosal invasive cancer, respectively.

    DOI PubMed

  • Assessment of epigenetic alterations in early colorectal lesions containing BRAF mutations

    Takeshi Sawada, Eiichiro Yamamoto, Hiro-o Yamano, Masanori Nojima, Taku Harada, Reo Maruyama, Masami Ashida, Hironori Aoki, Hiro-o Matsushita, Kenjiro Yoshikawa, Eiji Harada, Yoshihito Tanaka, Shigenori Wakita, Takeshi Niinuma, Masahiro Kai, Makoto Eizuka, Tamotsu Sugai, Hiromu Suzuki

    ONCOTARGET ( IMPACT JOURNALS LLC )  7 ( 23 ) 35106 - 35118  2016.06  [Refereed]

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    To clarify the molecular and clinicopathological characteristics of colorectal serrated lesions, we assessed the DNA methylation of cancer-associated genes in a cohort of BRAF-mutant precancerous lesions from 94 individuals. We then compared those results with the lesions' clinicopathological features, especially colorectal subsites. The lesions included hyperplastic polyps (n = 16), traditional serrated adenomas (TSAs) (n = 15), TSAs with sessile serrated adenomas (SSAs) (n = 6), SSAs (n = 49) and SSAs with dysplasia (n = 16). The prevalence of lesions exhibiting the CpG island methylator phenotype (CIMP) was lower in the sigmoid colon and rectum than in other bowel subsites, including the cecum, ascending, transverse and descending colon. In addition, several cancer-associated genes showed higher methylation levels within lesions in the proximal to sigmoid colon than in the sigmoid colon and rectum. These results indicate that the methylation status of lesions with BRAF mutation is strongly associated with their location, histological findings and neoplastic pathways. By contrast, no difference in aberrant DNA methylation was observed in normal-appearing background colonic mucosa along the bowel subsites, which may indicate the absence of an epigenetic field defect.

    DOI PubMed

  • What is type II-open pit pattern?

    Hiro-o Matsushita, Hiro-o Yamano

    DIGESTIVE ENDOSCOPY ( WILEY-BLACKWELL )  28   60 - 60  2016.04  [Refereed]

    DOI PubMed

  • Epigenetic silencing of NTSR1 is associated with lateral and noninvasive growth of colorectal tumors

    Seiko Kamimae, Eiichiro Yamamoto, Masahiro Kai, Takeshi Niinuma, Hiro-o Yamano, Masanori Nojima, Kennjiro Yoshikawa, Tomoaki Kimura, Ryo Takagi, Eiji Harada, Taku Harada, Reo Maruyama, Yasushi Sasaki, Takashi Tokino, Yasuhisa Shinomura, Tamotsu Sugai, Kohzoh Imai, Hiromu Suzuki

    ONCOTARGET ( IMPACT JOURNALS LLC )  6 ( 30 ) 29975 - 29990  2015.10  [Refereed]

    　View Summary

    Our aim was to identify DNA methylation changes associated with the growth pattern and invasiveness of colorectal cancers (CRCs). Comparison of the methylation statuses of large (>= 20 mm in diameter along the colonic surface) noninvasive tumors (NTs) and small (<20 mm in diameter along the colonic surface) invasive tumors (ITs) using CpG island microarray analysis showed neurotensin receptor 1 (NTSR1) to be hypermethylated in large NTs. Quantitative bisulfite pyrosequencing revealed that NTSR1 is frequently methylated in colorectal tumors, with large NTs exhibiting the highest methylation levels. The higher NTSR1 methylation levels were associated with better prognoses. By contrast, NTSR1 copy number gains were most frequent among small ITs. Methylation of NTSR1 was associated with the gene's silencing in CRC cell lines, whereas ectopic expression of NTSR1 promoted proliferation and invasion by CRC cells. Analysis of primary tumors composed of adenomatous and malignant portions revealed that NTSR1 is frequently methylated in the adenomatous portion, while methylation levels are generally lower in the cancerous portions. These results suggest that NTSR1 methylation is associated with lateral and noninvasive growth of colorectal tumors, while low levels of methylation may contribute to the malignant potential through activation of NTSR1. Our data also indicate that NTSR1 methylation may be a prognostic biomarker in CRC.

    DOI PubMed

  • Endoscopic diagnosis and clinical management for serrated lesions of the large intestine

    Hiroo Yamano, Yoshihito Tanaka, Hiroo Matsushita, Kenjiro Yoshikawa, Ryo Takagi, Eiji Harada, Michiko Nakaoka, Ryogo Himori, Yuko Yoshida, Daiki Tanaka, Kentaro Sato, Yasushi Imai, Tamotsu Sugai, Makoto Eizuka, Eiichiro Yamamoto, Hironori Aoki, Hiromu Suzuki

    Journal of Japanese Society of Gastroenterology ( Japanese Society of Gastroenterology )  112 ( 4 ) 676 - 682  2015  [Refereed]

    DOI PubMed

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Misc 【 display / non-display 】

  • COLLISION TUMOR OF A SERRATED LESION AND ADENOMA IN THE RECTUM

    YOSHIDA Yuko, YAMAMOTO Ei-ichiro, YAMANO Hiro-o, MATSUSHITA Hiro-o, YOSHIKAWA Kenjiro, HARADA Eiji, TAKAGI Ryo, TANAKA Yoshihito, SUGAI Tamotsu, EIZUKA Makoto

    Gastroenterol. Endosc. ( Japan Gastroenterological Endoscopy Society )  59 ( 10 ) 2521 - 2525  2017

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    <p>During a secondary screening visit by an 81-year-old man at our hospital, we detected a 5-mm flat elevated lesion in the rectum while performing total colonoscopy. The lesion consisted of a white, flat, elevated portion and a reddened protruding portion. On magnified endoscopy, the white, flat, elevated portion showed a type Ⅱ pit pattern and the reddened protruding portion showed a type Ⅲ<sub>L</sub> pit pattern. To assess the possibilities of a partial change in the serrated lesion or the development of a collision tumor in the serrated lesion along with adenoma, endoscopic mucosal resection was performed. Pathological examination determined that the flat elevated portion was a hyperplastic polyp and that the protruding portion was tubular adenoma. Molecular biological analysis indicated a <i>K-ras</i> mutation only in the white flat elevated portion, and neither a <i>K-ras</i> mutation nor a <i>BRAF</i> mutation was observed in the reddened protruding portion. The findings on endoscopy, pathology, and molecular biology analysis indicated that the growth was a collision tumor of a hyperplastic polyp and tubular adenoma.</p>

    DOI CiNii

  • 大腸癌の内視鏡Up-to-date 安全かつ確実な大腸EMRテクニック

    松下 弘雄, 山野 泰穂, 吉川 健二郎, 髙木 亮, 原田 英嗣, 田中 義人, 中岡 宙子, 吉田 優子, 佐藤 健太郎, 今井 靖

    大腸がんperspective : new perspectives in the treatment of colorectal cancer ( メディカルレビュー社 )  3 ( 3 ) 208 - 211  2017

    CiNii

  • NBI MAGNIFYING ENDOSCOPIC CLASSIFICATION OF COLORECTAL TUMORS PROPOSED BY THE JAPAN NBI EXPERT TEAM (JNET)

    SAITO Yutaka, KAWANO Hiroshi, SANO Yasushi, TANAKA Shinji, FUJII Takahiro, KUDO Shin-ei, URAOKA Toshio, KOBAYASHI Nozomu, NAKAMURA Hisashi, HOTTA Kinichi, HORIMATSU Takahiro, MATSUDA Takahisa, SAKAMOTO Naoto, FU Kuang-I, TSURUTA Osamu, KASHIDA Hiroshi, TAKEUCHI Yoji, MACHIDA Hirohisa, KUSAKA Toshihiro, YOSHIDA Naohisa, HIRATA Ichiro, TERAI Takeshi, NAKAJIMA Takeshi, YAMANO Hiro-o, KANEKO Kazuhiro, YAMAGUCHI Yuichiro, TAMAI Naoto, NAKANO (MARUYAMA) Naoko, HAYASHI Nana, IWATATE Mineo, ISHIKAWA Hideki, YOSHIDA Shigeaki, The Japan, NBI Expert, Team (JNET, SAKAMOTO Taku, YAMADA Masayoshi, SAITO Shoichi, IKEMATSU Hiroaki, WADA Yoshiki, OKA Shiro

    Gastroenterol. Endosc. ( Japan Gastroenterological Endoscopy Society )  58 ( 11 ) 2314 - 2322  2016

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    <p>Many clinical studies on narrow-band imaging (NBI) have reported the usefulness of NBI magnifying endoscopy for qualitative and quantitative diagnosis of colorectal lesions in Japan. However, critical discussions have raised issues such as i) the presence of multiple terms for similar findings, ii) the necessity of taking into account surface patterns, and iii) differences in NBI findings between elevated (polypoid growth, PG) and superficial lesions (non-polypoid growth, NPG).</p><p>The Japan NBI Expert Team (JNET) was constituted with the aim of establishing a universal NBI magnifying endoscopic classification of colorectal tumors (JNET classification) in 2011.</p><p>To establish a universal NBI magnifying endoscopic classification of colorectal tumors, the JNET, consisting of 38 NBI expert members, was formed within the "Research Group of the National Cancer Center Research and Development Fund" (Yutaka Saito Group) in 2011.</p><p>First, a working group was organized consisting of young but experienced researchers from six institutions in order to establish common evaluation criteria of the JNET classification. Consequently, normal/hyperplastic lesions were classified as type 1, low-grade adenomas as type 2A, high-grade adenomas as type 2B, and deep submucosal invasive cancers as type 3, and a magnifying NBI scale that took into account the vascular and surface patterns was created for both PG and NPG tumors.</p><p>A web-based interpretation study was conducted by a JNET member in order to determine the NBI findings and diagnostic criteria to be used in the universal classification system in 2013. A JNET classification system was established based on the results of univariate/multivariate analyses using a modified Delphi method at a consensus meeting on June 6, 2014.</p><p>The JNET classification consists of four categories of vessel and surface patterns, i.e., Types 1, 2A, 2B, and 3. Types 1, 2A, 2B, and 3 are correlated with the histopathological findings of hyperplastic polyp/sessile serrated polyp (SSA/P), low-grade intramucosal neoplasia, high-grade intramucosal neoplasia/superficial submucosal invasive cancer, and deep submucosal invasive cancer, respectively.</p><p>At present, validation studies for the JNET classification have been proposed to be conducted. </p>

    DOI CiNii

  • Basic techniques of endoscopic mucosal resection for colorectal lesion

    松下 弘雄, 山野 泰穂, 吉川 健二郎, 高木 亮, 原田 英嗣, 田中 義人, 中岡 宙子, 吉田 優子, 佐藤 健太郎, 今井 靖

    日本大腸検査学会雑誌 = Journal of colon examination ( 日本大腸検査学会 )  32 ( 2 ) 117 - 122  2016

    CiNii

  • 大腸癌の内視鏡Up-to-date SSAﾉPの内視鏡診断と臨床的取り扱い

    山野 泰穂, 青木 敬則, 松下 弘雄

    大腸がんperspective : new perspectives in the treatment of colorectal cancer ( メディカルレビュー社 )  1 ( 2 ) 122 - 127  2014

    CiNii

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Awards 【 display / non-display 】

  • Best Doctors in Japan 2018-2019

    2018   法研  

    Winner： 山野 泰穂

  • Best Doctors in Japan 2016-2017

    2016   法研  

    Winner： 山野 泰穂

  • Best Doctors in Japan 2014-2015

    2014   法研  

    Winner： 山野 泰穂

  • 第19回白壁賞

    2013   雑誌「胃と腸」（医学書院）  

    Winner： 山野 泰穂

  • 平成19年度早期胃癌研究会 年間最優秀症例賞

    2007   早期胃癌研究会  

    Winner： 山野 泰穂

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