Details of a Researcher - UHARA Hisashi

Papers - UHARA Hisashi

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日本人のメラノーマのおけるBRAF、NRAS、KITの遺伝子変異の解析

芦田敦子, 宇原久, 奥山隆平

日本皮膚悪性腫瘍学会学術大会プログラム・抄録集 ( (一社)日本皮膚悪性腫瘍学会 ) 29回 137 - 137 2013.08

芦田敦子, 木庭幸子, 宇原久, 奥山隆平

日本臨床 ( (株)日本臨床社 ) 71 ( 増刊4 皮膚悪性腫瘍 ) 134 - 138 2013.08

A case of hypocomplementaemic urticarial vasculitis with a high serum level of rheumatoid factor

Atsuko Ashida, Hiroshi Murata, Atsuko Ohashi, Eisaku Ogawa, Hisashi Uhara, Ryuhei Okuyama

Australasian Journal of Dermatology 54 ( 3 ) e62 - e63 2013.08 [Refereed]

We report a case of hypocomplementaemic urticarial vasculitis with an elevated serum rheumatoid factor level. Hypocomplementaemic urticarial vasculitis is an immune complex-mediated disease characterised by urticarial eruptions. High levels of rheumatoid factor may be associated with hypocomplementaemia due to the consumption of complement, because the rheumatoid factor can form immune complexes with immunoglobulin. It is necessary to pay attention to the amounts of complement in cases of urticarial eruptions with elevated rheumatoid factor level. The eruptions were relieved with a combination of prednisolone and colchicine. © 2012 The Australasian College of Dermatologists.

DOI PubMed

古賀弘志, 宇原久, 奥山隆平

日本臨床 ( (株)日本臨床社 ) 71 ( 増刊4 皮膚悪性腫瘍 ) 507 - 511 2013.08

古賀弘志, 宇原久, 奥山隆平

日本臨床 ( (株)日本臨床社 ) 71 ( 増刊4 皮膚悪性腫瘍 ) 392 - 396 2013.08

汗孔角化症のダーモスコピー所見

宇原久, 古賀弘志, 奥山隆平, 斎田俊明

日本皮膚科学会雑誌 ( (公社)日本皮膚科学会 ) 123 ( 8 ) 1559 - 1559 2013.07

Clinical course of drug-induced hypersensitivity syndrome treated without systemic corticosteroids

H. Uhara, M. Saiki, S. Kawachi, A. Ashida, S. Oguchi, R. Okuyama

Journal of the European Academy of Dermatology and Venereology 27 ( 6 ) 722 - 726 2013.06 [Refereed]

Background/aim Drug-induced hypersensitivity syndrome (DIHS) is a severe reaction to drugs which characteristically occurs after a long latency period. In addition, human herpes virus 6 (HHV-6) reactivation is a characteristic finding in DIHS, which has been known to be related to disease severity. Because DIHS has generally been treated by systemic corticosteroids, the natural clinical course is not clear. Methods Data for patients with both DIHS and HHV-6 reactivation were retrospectively collected from four hospitals. Results Data were collected on 12 patients ranging in age from 21 to 76 years (median, 65.5). All cases had been suspected of DIHS at their initial visit, and the elevation of serum anti-HHV-6 antibody had been confirmed (4-256 times: median 32). The culprit drugs were carbamazepine (6), salazosulfapyridine (4), mexiletine (1) and zonisamide (1). The period of latency from the first administration of the drug ranged from 15 to 50 days (median, 30). All patients were treated conservatively for DIHS without systemic corticosteroids. The peaks of the patients' symptoms and laboratory findings were as follows (days from the onset of skin lesions): fever, 4-16 (median, 10.5) liver abnormality, 3-22 (median, 7.5) leukocytosis, 7-20 (median, 9). All patients recovered without pneumonia, myocarditis, nephritis or other systemic disease, from 7 to 37 days (median, 18) after withdrawal of the drug and from 11 to 44 days (median, 21) after the onset of skin lesions. Conclusion It might be unnecessary to give systemic corticosteroids immediately to all patients suspected of having DIHS. © 2012 The Authors. Journal of the European Academy of Dermatology and Venereology © 2012 European Academy of Dermatology and Venereology.

DOI PubMed

Platinum and anthracycline therapy for advanced cutaneous squamous cell carcinoma

Kenta Nakamura, Ryuhei Okuyama, Toshiaki Saida, Hisashi Uhara

International Journal of Clinical Oncology 18 ( 3 ) 506 - 509 2013.06 [Refereed]

Background: Because metastatic cutaneous squamous cell carcinoma (CSCC) is rare, standard chemotherapy has not been fully established. In Japan, combination platinum and anthracycline chemotherapy has been used for elderly patients with advanced CSCC because of its low toxicity. However, the clinical benefit of this therapy has not been fully examined. Methods: We retrospectively examined the response rate of combination platinum and anthracycline chemotherapy for metastatic CSCC. Results: Eight patients received combination chemotherapy for metastatic lesions there were lymph node lesions in 6 patients and skin and lung lesions in one patient each. The combination regimens were as follows: cisplatin (CDDP) (60-90 mg/m2/day, day 1) and adriamycin (ADM) (20-40 mg/m2/day, day 1 or 2) was administered in 5 patients CDDP (10-15 mg/m2/day, days 1-5) and epirubicin (epi-ADM) (10-15 mg/m2/day, days 1-5) was administered in 2 patients and carboplatin (CBDCA) (200-400 mg/m2/day, day 1) and ADM (20-40 mg/m 2/day, day 1 or 2) was administered in one patient. The responses were as follows: complete response in 2 patients (CDDP + ADM for lung metastasis, CDDP + epi-ADM for lymph node metastasis), partial response in 1 (CDDP + ADM for lymph node metastasis), stable disease in 2, and progressive disease in 3. A durable response was observed in 2 patients showing complete responses (58 and 112 months). Conclusions: The clinical effect of the combination of platinum and anthracycline for metastatic CSCC was limited despite the findings of two patients showing durable complete responses. © 2012 Japan Society of Clinical Oncology.

DOI PubMed

マイコプラズマ感染により発症したStevens Johnson症候群(SJS)の1例

御子柴育朋, 大橋敦子, 芦田敦子, 村田浩, 宇原久, 奥山隆平

日本皮膚科学会雑誌 ( (公社)日本皮膚科学会 ) 123 ( 2 ) 171 - 171 2013.02

腹部に生じた隆起性皮膚線維肉腫(DFSP)病変を伴う線維肉腫の1例

大橋敦子, 芦田敦子, 村田浩, 宇原久, 奥山隆平, 吉田香奈子

日本皮膚科学会雑誌 ( (公社)日本皮膚科学会 ) 123 ( 2 ) 172 - 172 2013.02

喉頭狭窄をきたした後天性表皮水疱症の1例

木庭幸子, 大橋敦子, 芦田敦子, 宇原久, 奥山隆平, 小口真司

日本皮膚科学会雑誌 ( (公社)日本皮膚科学会 ) 123 ( 2 ) 171 - 171 2013.02

魚介による口腔アレルギー症候群の1例

御子柴育朋, 斉藤奈那, 大橋敦子, 芦田敦子, 村田浩, 宇原久, 奥山隆平

日本皮膚科学会雑誌 ( (公社)日本皮膚科学会 ) 123 ( 2 ) 173 - 173 2013.02

小児膿疱性乾癬の1例

御子柴育朋, 村田浩, 赤羽聡子, 佐藤勇樹, 芦田敦子, 宇原久, 奥山隆平

日本皮膚科学会雑誌 ( (公社)日本皮膚科学会 ) 123 ( 2 ) 174 - 174 2013.02

全身性サルコイドーシスに伴った刺青サルコイドーシスの1例

中村謙太, 大橋敦子, 古賀弘志, 宇原久, 奥山隆平

日本皮膚科学会雑誌 ( (公社)日本皮膚科学会 ) 123 ( 2 ) 174 - 174 2013.02

Dermoscopic characteristics of acquired melanocytic naevus in childhood affecting the acral region

Akane Minagawa, Hiroshi Koga, Hisashi Uhara, Ryuhei Okuyama

Acta Dermato-Venereologica 93 ( 6 ) 751 - 752 2013 [Refereed]

Dermoscopic findings in melanocytic naevus show characteristic patterns depending on age of onset and location (1, 2). On the trunk and extremities, a globular pattern is characteristic in both acquired melanocytic naevus (AMN) of childhood and in small-sized congenital melanocytic naevus (CMN), whereas a reticular pattern is common in melanocytic naevus in adulthood. Individual AMN on the back rarely change their dermoscopic patterns during adolescence (3) but the situation for AMN of the acral region has not been fully explored. We report here the results of dermoscopic analysis of acral AMN in children. © 2013 Acta Dermato-Venereologica.

DOI PubMed

Epidermal-type FABP is a predictive marker of clinical response to systemic treatment and ultraviolet therapy in psoriatic skin lesions.

Miyake T, Ogawa E, Mikoshiba A, Kobayashi A, Hosoe H, Kashiwabara S, Uhara H, Owada Y, Okuyama R

Journal of dermatological science 68 ( 3 ) 199 - 202 2012.12 [Refereed]

DOI PubMed

Cutaneous angiosarcoma of the leg showing radiation sensitivity

Atsuko Ohashi, Hitomi Kubo, Maiko Iwade, Junko Shiohara, Minoru Takata, Hisashi Uhara, Ryuhei Okuyama

Australasian Journal of Dermatology 53 ( 3 ) e51 - e53 2012.08 [Refereed]

We report a case of cutaneous angiosarcoma occurring on the leg of a 97-year-old Japanese woman. Considering the patient's age and general condition, she was treated with electron beam irradiation, which led to the almost complete disappearance of the tumour. Because cutaneous angiosarcoma is an aggressive tumour with a high propensity for local recurrence and distant metastases, therapy preferably involves a multimodal approach. However, monotherapy with radiation may be effective in some cases of cutaneous angiosarcoma. © 2011 The Australasian College of Dermatologists.

DOI PubMed

日本人の悪性黒色腫患者におけるBRAF、KIT遺伝子変異の解析(Assessment of BRAF and KIT mutations in Japanese melanoma patients)

芦田敦子, 宇原久, 村田浩, 後藤康文, 奥山隆平

日本癌学会総会記事 ( (一社)日本癌学会 ) 71回 359 - 359 2012.08

シクロスポリンが著効した小児膿疱性乾癬の1例

御子柴育朋, 村田浩, 赤羽聡子, 佐藤勇樹, 芦田敦子, 宇原久, 奥山隆平

日本皮膚科学会雑誌 ( (公社)日本皮膚科学会 ) 122 ( 9 ) 2336 - 2336 2012.08

【膿疱を伴う皮膚疾患(2)】<臨床例>治療に難渋した小児膿疱性乾癬

御子柴育朋, 芦田敦子, 村田浩, 宇原久, 奥山隆平

皮膚病診療 ( (株)協和企画 ) 34 ( 7 ) 683 - 686 2012.07

＜症例のポイント＞・膿疱性乾癬は乾癬全体の1%程度といわれ、比較的少数である。しかし、膿疱性乾癬は小児例が11.7%を占めることから、小児期に発症することが少なくないと思われる。・自験例ではステロイド薬、活性型ビタミンD3製剤の外用に反応せず、シクロスポリンの内服を行った。・シクロスポリン投与後、全身状態は安定し皮疹の改善は図られた。しかし、寛解には至らずときどき再燃がみられる。・乾癬は慢性的に継続するため、継続した治療が必要である。一方、小児の場合、治療の選択肢が限られ、治療に難渋する症例も少なくない。(著者抄録)

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