Degree 【 display / non-display 】

Degree 【 display / non-display 】

• 札幌医科大学   医学博士

Research Areas 【 display / non-display 】

Research Areas 【 display / non-display 】

• Life sciences   Obstetrics and gynecology  

Affiliation 【 display / non-display 】

Affiliation 【 display / non-display 】

• 札幌医科大学   産婦人科   講師  

Research Interests 【 display / non-display 】

Research Interests 【 display / non-display 】

• 婦人科腫瘍

Papers 【 display / non-display 】

Papers 【 display / non-display 】

• Identification of cancer driver mutations in liquid-based cytology samples for the screening of endometrial diseases

  Motoki Matsuura, Kiyoko Takane, Kiyoshi Yamaguchi, Tsuneo Ikenoue, Seira Hatakeyama, Shoko Kurokawa, Masato Tamate, Taishi Akimoto, Masahiro Iwasaki, Shintaro Sugita, Tadashi Hasegawa, Yasunori Ota, Tsuyoshi Saito, Yoichi Furukawa

  BJC Reports ( Springer Science and Business Media LLC )  1 ( 1 )  2023.11

  　View Summary

  Abstract Background Endometrial cancer (EC) is one of the leading causes of cancer death among women and early detection is crucial for its successful treatment. We previously showed that cytological examination combined with genetic analysis using liquid-based cytology (LBC) samples improved the diagnostic sensitivity of EC. Methods Among 218 individuals who underwent endometrial screening by LBC, 208 samples were analysed by cancer-panel sequencing. Excluding 13 samples with low sequence coverage, we further analysed 195 samples. Results Among the 195 women analysed, 39 and 15 were eventually shown to suffer from malignant endometrial and non-endometrial neoplasms, respectively. Driver mutation(s) were found in nine of the 15 cytology-negative patients with endometrial malignancy, corroborating that combination of cytological and genetic analyses should increase the sensitivity of the diagnosis of malignant endometrial neoplasms. Importantly, driver alterations were found in 32 of 125 women without malignant or premalignant diseases, which raises caution for the interpretation of genetic alterations detected in the endometrial samples. Comparison between the driver mutations in the 32 subjects and those in the 29 endometrial malignancies unveiled that the number of mutations and mutations in PTEN, CTNNB1, and TP53 may be applied for the assessment and prediction of development of EC. Conclusions The genetic analysis combined with liquid-based cytology is useful to improve the diagnostic sensitivity of endometrial neoplasms. However, caution must be taken when cancer-associated mutation(s) are detected in the genetic analysis. Further investigation may clarify the risk of malignant endometrial neoplasms in women with driver mutation(s).

  DOI

• 【婦人科悪性腫瘍手術-トラブルシューティングとその予防法-】単純外陰切除術

  齋藤 豪, 松浦 基樹, 玉手 雅人, 真里谷 奨

  産婦人科の実際 ( 金原出版(株) )  72 ( 12 ) 1397 - 1401  2023.11

• Laparoscopic retrovesical lower uterine segment bypass for hysterectomy with previous caesarean section: Hung Up the Bladder Bypass (HUBB) technique.

  Masato Tamate, Motoki Matsuura, Nagisa Wada, Takaki Adachi, Kazuma Yorozu, Chihiro Arimoto, Tsuyoshi Saito

  Journal of gynecology obstetrics and human reproduction     102629 - 102629  2023.07  [International journal]

  　View Summary

  Patients with a history of cesarean section and a highly adherent bladder may have difficulty in bladder dissection and may suffer damage. It may also be difficult to orient the patient for repair in the event of damage. In such cases, dissection from the side between the bladder and cervix is a good way to avoid complication. This video reviews the steps of the HUBB technique procedure, provides tips and tricks for performing a successful adhesiolysis, and illustrates the procedure's adaptability. The first is the identification of the uterine artery and its position. Step2, a Laparoscopic retrovesical lower uterine segment bypass is created. Step3 a Hung Up the Bladder Bypass is created, the bladder is completely dissected. Step4, an adhesiolysis and leak test is performed. In this report, we would like to introduce a technique for creating a retrovesical lower uterine segment bypass using a laparoscope and traction on the bypass to dissect the bladder.

  DOI PubMed

• 【AIがもたらす婦人科癌医療の新展開】深層学習を利用したHE染色からの子宮内膜癌MMR status判定の可否に関する検討

  梅本 美菜, 真里谷 奨, 永田 舞, 堀米 俊弘, 新開 翔太, 杉田 真太朗, 金関 貴幸, 松浦 基樹, 岩崎 雅宏, 廣橋 良彦, 長谷川 匡, 藤野 雄一, 鳥越 俊彦, 齋藤 豪

  日本婦人科腫瘍学会学術講演会プログラム・抄録集 ( (公社)日本婦人科腫瘍学会 )  65回   153 - 153  2023.07

• 当院における婦人科癌に対するがん遺伝子パネル検査の現状と課題

  野藤 五沙, 真里谷 奨, 田中 佑弥, 室田 文子, 寺本 瑞絵, 松浦 基樹, 岩崎 雅宏, 石川 亜貴, 高田 弘一, 櫻井 晃洋, 齋藤 豪

  日本婦人科腫瘍学会学術講演会プログラム・抄録集 ( (公社)日本婦人科腫瘍学会 )  65回   288 - 288  2023.07

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Misc 【 display / non-display 】

Misc 【 display / non-display 】

• Identification of cancer driver mutations in liquid endometrial biopsy for the screening of endometrial diseases.

  高根希世子, 松浦基樹, 山口貴世志, 池上恒雄, 畠山晴良, 黒川晶子, 玉手雅人, 秋元太志, 岩崎雅宏, 杉田慎太郎, 長谷川匡, 大田泰徳, 齋藤豪, 古川洋一

  日本癌学会学術総会抄録集(Web)   82nd  2023

  J-GLOBAL

• LBC検体によるNGSを子宮体癌早期スクリーニングにどう応用するべきか

  松浦基樹, 玉手雅人, 秋元太志, 幅田周太朗, 岩崎雅宏, 畠山晴良, 高根希世子, 山口貴世志, 古川洋一, 齋藤豪

  日本臨床細胞学会雑誌(Web)   62  2023

  J-GLOBAL

• プラチナ製剤感受性の日本人再発卵巣癌患者を対象としたニラパリブの第II相臨床試験の最終結果(The Final Results of a Phase 2 Study of Niraparib in Japanese Patients with Platinum-Sensitive Recurrent Ovarian Cancer)

  竹島 信宏, 安岡 稔晃, 濱西 潤三, 長谷川 幸清, 松浦 基樹, 三浦 清徳, 長尾 昌二, 中井 英勝, 田中 尚武, 徳永 英樹, 牛嶋 公生, 渡利 英道, 横山 良仁, 加瀬 陽一, 角野 修司, Suri Ajit, 板持 広明, 竹原 和宏

  日本婦人科腫瘍学会学術講演会プログラム・抄録集 ( (公社)日本婦人科腫瘍学会 )  64回   192 - 192  2022.07

• 前治療歴を有する高悪性度漿液性卵巣癌患者を対象としたニラパリブの国内第II相臨床試験の最終結果(The Final Results of a Japanese Phase 2 Study of Niraparib in Heavily Pretreated, HRd High-grade Serous Ovarian Cancer Patients)

  中村 俊昭, 田畑 務, 柳田 聡, 近藤 英司, 濱西 潤三, 原野 謙一, 長谷川 幸清, 平澤 猛, 堀 謙輔, 小宮山 慎一, 松浦 基樹, 中井 英勝, 中村 紘子, 坂田 純, 竹原 和宏, 武隈 宗孝, 横山 良仁, 加瀬 陽一, 杉山 徹, 青木 大輔

  日本婦人科腫瘍学会学術講演会プログラム・抄録集 ( (公社)日本婦人科腫瘍学会 )  64回   193 - 193  2022.07

• 血中エクソソーム由来miRNAを用いた子宮頸癌の治療効果予測

  染谷正則, 土屋高旭, 福島悠希, 長谷川智一, 井戸川雅史, 松浦基樹, 岩崎雅宏, 廣橋良彦, 鳥越俊彦, 齋藤豪, 坂田耕一

  日本癌治療学会学術集会(Web)   60th  2022

  J-GLOBAL

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