Updated on 2025/08/22

写真a

 
YAMAMOTO Keisuke
 
Organization
School of Medicine Department of Otolaryngology Lecturer
Title
Lecturer
ORCID ID
0000-0001-7758-2254
External link

MISC

  • Simulation Training to Ward Airway Emergencies

    Obata Kazufumi, Kakiuchi Akito, Yamamoto Keisuke, Kurose Makoto, Takano Kenichi

    Nippon Jibiinkoka Tokeibugeka Gakkai Kaiho(Tokyo)   128 ( 3 )   215 - 222   2025.3

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    Language：Japanese   Publisher：Japanese Society of Otorhinolaryngology-Head and Neck Surgery  

    Airway obstruction following head and neck surgery can result from bleeding, edema, or hematoma, potentially leading to serious complications. An effective response for postoperative airway emergencies in the ward requires not only technical skills, such as skills in performing tracheal intubation and tracheotomy, but also essential non-technical skills. These non-technical skills, including the ability to leverage individual capabilities within a team, complement technical expertise to promote safe and efficient care. Because executing non-technical skills in ward emergencies can be challenging, we considered that regular team-based training is crucial. To enhance the effectiveness of simulation, we conducted a rubric-based survey before and after the simulation to assess the achievement, the satisfaction level of the trainees, and areas that could be improved.

    This article outlines a ward emergency simulation program implemented in our department as a part of an exploration of ways to improve responses to airway emergencies in the ward.

    Other Link:： https://ndlsearch.ndl.go.jp/books/R000000004-I034066030

    DOI： 10.3950/jibiinkotokeibu.128.3_215

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  • 「複雑」で「直視できない」，前頭洞へのアプローチ

    山本 圭佑

    日本鼻科学会会誌   64 ( 1 )   184 - 185   2025

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    Language：Japanese   Publisher：日本鼻科学会  

    DOI： 10.7248/jjrhi.64.184

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  • 「複雑」で「直視できない」,前頭洞へのアプローチ

    山本圭佑

    日本鼻科学会会誌(Web)   64 ( 1 )   2025

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  • A Case of Killian-Jamieson Diverticulum Treated by Surgical Resection

    Sugaya Taiki, Yamamoto Keisuke, Kurose Makoto, Kakuki Takuya, Okuni Tsuyoshi, Takano Kenichi

    Nihon Kikan Shokudoka Gakkai Kaiho   75 ( 6 )   334 - 342   2024.12

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    Language：Japanese   Publisher：The Japan Broncho-esophagological Society  

    Pharyngoesophageal diverticulum is an infrequent type of diverticulum among all gastrointestinal diverticula, and among them, Killian-Jamieson diverticulum, which occurs between the inferior margin of the cricopharyngeal muscle and the longitudinal esophageal muscle, has been rarely reported. We report a case of Killian-Jamieson diverticulum treated by cervical incision. Preoperative cervical contrast-enhanced CT scan showed that the base of the diverticulum was located on the left side of the esophagus, caudal to the cricopharyngeal cartilage, which led us to suspect a Killian-Jamieson diverticulum. Many reports indicate that it is difficult to differentiate Zenker's diverticulum from Killian-Jamieson diverticulum in preoperative imaging studies. However, the location of the base of the diverticulum with reference to the cricopharyngeal cartilage to which the cricopharyngeal muscle attaches may provide a means of differentiation. The space where the Killian-Jamieson diverticulum originates is also the entrance to the recurrent nerve and is anatomically quite close. Therefore, it may be useful to safely exfoliate the thyroid gland by capsular dissection, and to ensure confirmation and preservation of the recurrent nerve by Nerve Integrity Monitor.

    Other Link:： https://ndlsearch.ndl.go.jp/books/R000000004-I033867895

    DOI： 10.2468/jbes.75.334

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  • Narrow band imaging accentuates differences in contrast between cartilage and perichondrium in the elevation of the muco-perichondrium flap during septoplasty and open septorhinoplasty.

    Keisuke Yamamoto, Tsuyoshi Okuni, Makoto Kurose, Takuya Kakuki, Masaya Nakano, Hiroshi Sakamoto, Kenichi Takano

    Nippon Jibiinkoka Tokeibugeka Gakkai Kaiho(Tokyo)   127 ( 5 )   686 - 688   2024.5

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    Language：Japanese   Publisher：Japanese Society of Otorhinolaryngology-Head and Neck Surgery  

    Other Link:： https://ndlsearch.ndl.go.jp/books/R000000004-I033546980

    DOI： 10.3950/jibiinkotokeibu.127.5_686

    ORCID Put Code : 110521915

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  • 特集 ポストコロナ時代のアレルギー性鼻炎診療 コロナ禍における話題 オンライン診療における課題

    高野 賢一, 山本 圭佑

    JOHNS   40 ( 5 )   487 - 490   2024.5

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  • 鼻腔に発生したPEComaの一例

    立花愛響, 立花愛響, 山本圭佑, 宮田遼, 大國毅, 高野賢一

    日本鼻科学会会誌(Web)   63 ( 3 )   2024

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  • Application of the VANS method in endoscopic-assisted thyroid surgery: a clinical experience

    Kurose Makoto, Kakiuchi Akito, Yamamoto Keisuke, Obata Kazufumi, Oyanagi Masahiko, Yorozu Akira, Okuni Tsuyoshi, Takano Kenichi

    JOURNAL OF JAPAN SOCIETY FOR HEAD AND NECK SURGERY   34 ( 2 )   165 - 169   2024

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    Language：Japanese   Publisher：JAPAN SOCIETY FOR HEAD AND NECK SURGERY  

    Video-assisted neck surgery （VANS） is a surgical technique that offers superior cosmetic outcomes and is gaining popularity. In this study, we retrospectively reviewed 31 cases （1 male, 30 females） who underwent VANS at our department from June 1, 2019 to July 31, 2023. The patients’ ages ranged from 16 to 66 years, with a median age of 38 years. Preoperative diagnoses included 24 cases of benign nodules and 7 cases of malignant tumors. The surgeries were performed via a subclavian approach for partial thyroidectomy. Tumor sizes ranged from 7 to 45mm （median: 35mm）, and operative times ranged from 89 to 250 minutes （median: 139 minutes）. Most cases exhibited minimal blood loss. Two cases experienced transient recurrent laryngeal nerve palsy, and one case required additional cervical incision. However, there were no cases of postoperative infection or reoperation due to postoperative hemorrhage.

    Other Link:： https://search.jamas.or.jp/link/ui/2025047192

    DOI： 10.5106/jjshns.34.165

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  • 内視鏡下鼻副鼻腔手術―前頭洞病変の治療戦略―

    司会:鴻 信義, 和田 弘太, 演者:山本 圭佑, 青石 邦秀, 青木 聡, 寺西 裕一

    日本鼻科学会会誌   63 ( 3 )   292 - 296   2024

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    Language：Japanese   Publisher：日本鼻科学会  

    DOI： 10.7248/jjrhi.63.292

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  • 経口的ロボット支援手術におけるDa Vinci SPの使用経験

    黒瀬誠, 垣内晃人, 山本圭佑, 小幡和史, 大國毅, 高野賢一

    日本頭頸部外科学会総会ならびに学術講演会プログラム・予稿集(CD-ROM)   33rd   2024

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  • シリンジ吸引法が有用であった頭頸部脂肪腫症例

    垣内晃人, 黒瀬誠, 山本圭佑, 小幡和史, 大國毅, 高野賢一

    日本頭頸部外科学会総会ならびに学術講演会プログラム・予稿集(CD-ROM)   33rd   2024

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  • ダニ舌下免疫療法の新しい効果発現のメカニズムの検証

    亀倉隆太, 重原克則, 山本圭佑, 大國毅, 高野賢一

    アレルギー   73 ( 6/7 )   2024

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  • 経鼻または経鼻・経頭蓋コンバインドアプローチで切除した前頭蓋底悪性腫瘍症例の検討

    大國毅, 山本圭佑, 高野賢一

    日本鼻科学会会誌(Web)   63 ( 3 )   2024

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  • 当科における経口的ロボット支援手術の現況

    黒瀬誠, 垣内晃人, 山本圭佑, 小幡和史, 高野賢一

    日本耳鼻咽喉科頭頚部外科学会会報   127 ( 4 )   2024

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  • 下咽頭から甲状腺に刺入した魚骨異物の1例

    浜淵永友, 垣内晃人, 黒瀬誠, 大國毅, 亀倉隆太, 山本圭佑, 高野賢一

    口腔・咽頭科(Web)   37 ( 3 )   2024

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  • 頭頸部術後気道トラブルに対する病棟緊急時シミュレーション

    小幡和史, 黒瀬誠, 山本圭佑, 垣内晃人, 高野賢一

    日本耳鼻咽喉科頭頚部外科学会会報   127 ( 4 )   2024

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  • レンバチニブ導入における至適マネジメント導入前後の比較

    高柳心, 高柳心, 黒瀬誠, 小幡和史, 山本圭佑, 垣内晃人, 高野賢一

    日本内分泌外科学会雑誌   41 ( Supplement 1 )   2024

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  • Narrow Band Imagingを併用した被膜間摘出術によって経鼻内視鏡手術を行った頭蓋外三叉神経鞘腫症例

    山本圭佑, 大國毅, 黒瀬誠, 垣内晃人, 小幡和史, 高野賢一

    日本頭頸部外科学会総会ならびに学術講演会プログラム・予稿集(CD-ROM)   33rd   2024

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  • 「複雑」で「直視できない」,前頭洞へのアプローチ

    山本圭佑

    日本鼻科学会会誌(Web)   63 ( 3 )   2024

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  • 甲状腺手術における一過性反回神経麻痺の改善時期についての検討

    小幡和史, 黒瀬誠, 山本圭佑, 垣内晃人, 高野賢一

    日本頭頸部外科学会総会ならびに学術講演会プログラム・予稿集(CD-ROM)   33rd   2024

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  • レンバチニブ導入における至適マネジメント導入前後の比較

    高柳心, 實川純人, 黒瀬誠, 山本圭佑, 小幡和史, 高野賢一

    耳鼻咽喉科臨床 補冊   ( 166 )   2024

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  • 特集 副鼻腔炎診療は変わったか? 知っておくべき副鼻腔炎を伴う全身疾患 IgG4関連疾患

    山本 圭佑, 高野 賢一

    JOHNS   39 ( 2 )   189 - 193   2023.2

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  • レンバチニブ導入における至適マネジメント導入前後の比較

    實川純人, 黒瀬誠, 村山公介, 垣内晃人, 山本圭佑, 小幡和史, 高野賢一

    頭頸部癌   49 ( 2 )   2023

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  • 当科における経口的ロボット支援手術(TORS)の初期経験

    黒瀬誠, 小幡和史, 山本圭佑, 垣内晃人, 大柳政彦, 高野賢一

    日本ロボット外科学会学術集会プログラム・抄録集   15th   2023

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  • Three cases of pyriform sinus fistula treated with transoral fistula cauterization

    菅谷泰樹, 山本圭佑, 角木拓也, 大國毅, 黒瀬誠, 高野賢一

    口腔・咽頭科(Web)   36 ( 1 )   2023

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  • 頭頸部扁平上皮癌におけるタイト結合分子と細胞周期の調整に着目したHDAC阻害剤作用機序の解析

    垣内晃人, 黒瀬誠, 小幡和史, 山本圭佑, 實川純人, 村山公介, 大柳政彦, 高野賢一

    頭頸部癌   49 ( 2 )   2023

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  • ZigZag flap incisionを加えた有茎鼻中隔粘・骨膜弁およびinverted edges flapにて閉鎖した再発性鼻中隔穿孔

    田村尚也, 大國毅, 山本圭佑, 吉田有梨枝, 黒瀬誠, 黒瀬誠, 高野賢一

    耳鼻咽喉科臨床 補冊   ( 161 )   2023

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  • レンバチニブ導入における至適マネジメント導入前後の比較

    實川純人, 黒瀬誠, 村山公介, 垣内晃人, 山本圭佑, 高野賢一

    耳鼻咽喉科臨床 補冊   ( 161 )   2023

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  • 咽頭食道憩室(Killian-Jamieson憩室)の1例

    菅谷泰樹, 山本圭佑, 黒瀬誠, 角木拓也, 大國毅, 高野賢一

    口腔・咽頭科(Web)   36 ( 3 )   2023

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  • 掌蹠膿疱症に対する口蓋扁桃摘出術の効果発現の免疫学的メカニズムの解明

    亀倉隆太, 酒本博史, 山本圭佑, 大國毅, 高野賢一

    日本耳鼻咽喉科頭頚部外科学会会報   126 ( 4 )   2023

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  • スパルフロキサシンによるRespiratory syncytial virus複製抑制機構の解明

    谷向由佳, 谷向由佳, 小笠原徳子, 小笠原徳子, 山本圭佑, 山本圭佑, 横田伸一, 高野賢一

    日本耳鼻咽喉科免疫アレルギー感染症学会総会・学術講演会プログラム・抄録集(CD-ROM)   3rd   2023

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  • デュピルマブが有効であった好酸球性副鼻腔炎合併IgG4関連疾患症例の検討

    亀倉隆太, 山本圭佑, 大國毅, 高野賢一

    日本耳鼻咽喉科免疫アレルギー感染症学会総会・学術講演会プログラム・抄録集(CD-ROM)   3rd   2023

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  • 抗zic4抗体陽性の傍腫瘍性神経症候群を呈した耳下腺癌の一例

    大柳政彦, 垣内晃人, 山本圭佑, 黒瀬誠, 高野賢一

    頭頸部癌   49 ( 2 )   2023

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  • 当科における経口的ロボット支援手術(TORS)の初期経験

    黒瀬誠, 小幡和史, 山本圭佑, 垣内晃人, 實川純人, 村山公介, 大柳政彦, 高野賢一

    頭頸部癌   49 ( 2 )   2023

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  • Hemitransfixionアプローチにて矯正術を施行した鼻中隔前弯症例の術前後CT変化の検討

    大國毅, 山本圭佑, 高野賢一

    日本鼻科学会会誌(Web)   62 ( 3 )   2023

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  • 当院における上咽頭癌治療11年間のまとめと放射性晩期障害として認めた舌線維束性攣縮についての報告

    垣内晃人, 小幡和史, 黒瀬誠, 大國毅, 山本圭佑, 村山公介, 大柳政彦, 高野賢一

    日本頭頸部外科学会総会ならびに学術講演会プログラム・予稿集(CD-ROM)   32nd   2023

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  • 生物学的製剤が奏功したと思われる難治性AFRSの1例

    萬顕, 大和田築, 伊藤史恵, 矢島諒人, 角木拓也, 宮田遼, 山本圭佑, 吉岡巌, 高野賢一

    日本鼻科学会会誌(Web)   62 ( 3 )   2023

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  • 好酸球性副鼻腔炎合併IgG4関連疾患に対するデュピルマブ投与の臨床的有用性の検証

    亀倉隆太, 山本圭佑, 大國毅, 高野賢一

    日本鼻科学会会誌(Web)   62 ( 3 )   2023

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  • Partial thyroidectomy: Preserving the function of the recurrent laryngeal nerve and parathyroid gland

    Kurose Makoto, Kakiuchi Akito, Ohkuni Tsuyoshi, Obata Kazufumi, Yamamoto Keisuke, Murayama Kosuke, Takano Kenichi

    JOURNAL OF JAPAN SOCIETY FOR HEAD AND NECK SURGERY   32 ( 3 )   221 - 226   2023

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    Language：Japanese   Publisher：JAPAN SOCIETY FOR HEAD AND NECK SURGERY  

    The prevalence of thyroid cancer is on the rise in Japan. Thyroid surgery is often selected as an introduction to head and neck surgery. However, when complications such as recurrent laryngeal nerve palsy and hypoparathyroidism occur, the patient’s QOL is significantly reduced. It is necessary to preserve not only the morphology of the recurrent laryngeal nerve but also its function. The reliability of intraoperative nerve monitoring has been greatly improved by establishing guidelines. In particular, intraoperative continuous nerve monitoring by vagus nerve stimulation is expected to reduce the occurrence of recurrent laryngeal nerve palsy. Preservation of the parathyroid gland is also important. In recent years, the usefulness of a method for detecting the parathyroid gland using an infrared observation camera system utilizing the autofluorescence characteristics of the parathyroid gland has been reported.

    Other Link:： https://search.jamas.or.jp/link/ui/2023142364

    DOI： 10.5106/jjshns.32.221

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  • 鼻閉改善手術におけるコストパフォーマンスとタイムパフォーマンス

    山本圭佑, 大國毅, 高野賢一

    日本鼻科学会会誌(Web)   62 ( 3 )   2023

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  • デュピルマブ投与によるIgG4関連疾患の臨床的有用性と免疫学的変化の検証

    亀倉隆太, 山本圭佑, 神田真聡, 山本元久, 高橋裕樹, 高野賢一

    日本シェーグレン症候群学会学術集会プログラム・抄録集   31st   2023

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  • ダニ舌下免疫療法の新しい効果発現のメカニズムの解明

    亀倉隆太, 亀倉隆太, 重原克則, 山本圭佑, 一宮慎吾, 高野賢一

    アレルギー   72 ( 6/7 )   2023

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  • IgG4関連疾患に伴う鼻副鼻腔病変

    山本 圭佑

    日本鼻科学会会誌   61 ( 1 )   229 - 230   2022

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    Language：Japanese   Publisher：日本鼻科学会  

    Other Link:： https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-22K09670/

    DOI： 10.7248/jjrhi.61.229

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  • Usefulness of Dual Knot Fixation Method for Correcting Nasal Septum Deviation Hemitransfixion Approach

    Okuni Tsuyoshi, Yamamoto Keisuke, Takano Kenichi

    Nihon Bika Gakkai Kaishi (Japanese Journal of Rhinology)   61 ( 4 )   632 - 639   2022

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    Language：Japanese   Publisher：Japan Rhinologic Society  

    Correction of caudal septum deviation requires surgical manipulation from the caudal side of the septum. In a case of concomitant external nasal deformity, an external method (i.e. – open septorhinoplasty) is selected, whereas in other cases, an endoscopic method (i.e. a hemitransfixion approach) is indicated. This type of nasal septal deviation is caused by an excessive cartilaginous nasal septum in relation to the bony septum. After the surgeon has separated the nasal septum cartilage from the anterior nasal spine (ANS) and trimmed the cartilage at the posterior nasal angle to ensure proper cartilage size, an anchoring suture is performed to reattach the cartilage and ANS. However suture manipulation is often difficult in the nasal endoscopic method due to the narrow surgical area. In this study, we compared the figure-8 suture and dual knot fixation (DKF) technique as methods of anchor suture for nasal endoscopic septoplasty. Our results show that DKF may be useful as a low-stress suture method for surgeons performing endonasal septoplasty.

    Other Link:： https://search.jamas.or.jp/link/ui/2023108931

    DOI： 10.7248/jjrhi.61.632

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  • 客観性を重視し,効率的な手術記載を目指して

    黒瀬誠, 近藤敦, 小幡和史, 山本圭佑, 高野賢一

    頭頸部癌   48 ( 2 )   2022

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  • Drug-repositioningによる抗RSV治療薬開発のための基礎研究

    谷向由佳, 小笠原徳子, 小笠原徳子, 山本圭佑, 山本圭佑, 高野賢一

    日本耳鼻咽喉科免疫アレルギー感染症学会総会・学術講演会プログラム・抄録集(CD-ROM)   2nd   2022

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  • ゼロから始める甲状腺半切除術 反回神経・副甲状腺の機能温存

    黒瀬誠, 近藤敦, 小幡和史, 山本圭佑, 高野賢一

    日本頭頸部外科学会総会ならびに学術講演会プログラム・予稿集   31st   2022

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  • 生物学的製剤が奏功したと思われる難治性AFRSの1例

    萬顕, 宮田遼, 山本圭佑, 吉岡巌, 高野賢一

    日本鼻科学会会誌(Web)   61 ( 3 )   2022

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  • 好酸球性副鼻腔炎患者における嗅覚障害と嗅球の検討

    山本圭佑, 宮田遼, 小笠原徳子, 亀倉隆太, 大國毅, 高野賢一

    日本鼻科学会会誌(Web)   61 ( 3 )   2022

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  • アレルギー性鼻炎の病態形成における鼻粘膜上皮の役割

    亀倉隆太, 亀倉隆太, 山本圭佑, 一宮慎吾, 高野賢一

    アレルギー   71 ( 6/7 )   2022

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  • IgG4関連疾患に関連した鼻副鼻腔炎の1例

    酒本博史, 亀倉隆太, 村山公介, 山本圭佑, 大國毅, 高野賢一

    日本鼻科学会会誌(Web)   61 ( 3 )   2022

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  • 上咽頭癌に対する化学放射線療法施行後に舌の線維束性攣縮を生じた1例

    大柳政彦, 垣内晃人, 大國毅, 黒瀬誠, 亀倉隆太, 山本圭祐, 菅谷泰樹, 高野賢一

    口腔・咽頭科(Web)   35 ( 3 )   2022

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  • IgG4関連疾患における末梢ヘルパーT細胞と濾胞外B細胞の機能的役割

    亀倉隆太, 山本圭佑, 神田真聡, 山本元久, 高橋裕樹, 高野賢一

    日本シェーグレン症候群学会学術集会プログラム・抄録集   30th   2022

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  • 内視鏡下鼻副鼻腔手術に対する術中視覚誘発電位の使用経験

    山本圭佑, 大國毅, 小幡和史, 黒瀬誠, 近藤敦, 高野賢一

    日本頭頸部外科学会総会ならびに学術講演会プログラム・予稿集   31st   2022

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  • 末梢ヘルパーT細胞と濾胞外B細胞の相互作用がIgG4関連疾患の病態形成に関与する

    亀倉隆太, 酒本博史, 村山公介, 山本圭佑, 高野賢一

    口腔・咽頭科(Web)   35 ( 3 )   2022

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  • 前頭洞のう胞症例の臨床的検討

    大國毅, 山本圭佑, 中野雅也, 高野賢一

    日本鼻科学会会誌(Web)   61 ( 3 )   2022

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  • 副甲状腺癌症例

    山本圭佑, 山下智久, 長南新太, 赤澤史子, 角木拓也, 黒瀬誠, 高野賢一

    日本耳鼻咽喉科免疫アレルギー感染症学会総会・学術講演会プログラム・抄録集(CD-ROM)   2nd   2022

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  • 前頭洞乳頭腫の臨床的検討

    大國毅, 山本圭佑, 角木拓也, 関伸彦, 高野賢一

    日本耳鼻咽喉科頭頚部外科学会会報   125 ( 4 )   2022

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  • Association between olfactory cleft obstruction and olfactory dysfunction in coronavirus disease patients Reviewed

    Yamamoto Keisuke, Fujiya Yoshihiro, Yama Naoya, Kuronuma Koji, Ogasawara Noriko, Yokota Shin-ichi, Takahashi Satoshi, Takano Kenichi

    Journal of Immunology, Allergy and Infection in Otorhinolaryngology   2 ( 2 )   49 - 54   2022

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    Language：Japanese   Publisher：Japan Society of Immunology, Allergology and Infection in Otorhinolaryngology  

    Background: Impaired olfaction is one of the characteristic symptoms of coronavirus disease (COVID-19). The olfactory cleft of COVID-19 patients with olfactory dysfunction reportedly appears closed on sinus computed tomography (CT). However, the etiology of olfactory cleft obstruction in these patients, including its frequency, severity, and mechanism, has not been fully elucidated. This study investigated the relationship between the olfactory dysfunction and olfactory cleft obstruction in COVID-19 patients.

    Methods: Among the COVID-19 patients treated at our hospital between April 2020 and January 2021, this study included 91 patients who underwent sinus CT examination. The data on the presence or absence of olfactory dysfunction was collected retrospectively from electronic medical records. Olfactory cleft obstruction was scored on a scale of 0–4, depending on the degree of obstruction. In patients with olfactory dysfunction, changes over time were evaluated using the visual analogue scale (VAS), self-administered odor questionnaire, open essence test, and CT score of the olfactory cleft.

    Results: Olfactory dysfunction was noted in 15 patients (16.5%). The CT score was significantly higher in patients with olfactory dysfunction than in those without, and the olfactory cleft tended to be closed in the former. The overall and perfume-related olfactory VAS scores, open-essence test, and CT scores improved significantly over time. There was a correlation between the changes in the olfactory dysfunction and changes in the CT scores.

    Conclusions: COVID-19 patients with olfactory dysfunction showed significant olfactory cleft obstruction on sinus CT, which could prevent the improvement of olfactory dysfunction in them.

    Other Link:： https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-22K09670/

    DOI： 10.24805/jiaio.2.2_49

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  • A case of suspected sarcoidosis with bilateral simultaneous facial nerve paralysis

    Nishida Soshi, Jitsukawa Sumito, Kakuki Takuya, Yamamoto Keisuke, Takano Kenichi

    Journal of Immunology, Allergy and Infection in Otorhinolaryngology   2 ( 4 )   197 - 202   2022

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    Language：Japanese   Publisher：Japan Society of Immunology, Allergology and Infection in Otorhinolaryngology  

    Bilateral facial nerve palsy is a rare condition accounting for approximately 5% of all facial palsies. Various systemic diseases may cause bilateral facial nerve palsy, one of which is sarcoidosis. Sarcoidosis is a systemic granulomatous disease that commonly affects the lungs, heart, and eyes, and may also involve the nervous system. The facial nerve is the most frequently affected cranial nerve in patients with neurosarcoidosis, with 40–60% of cases manifesting with facial paralysis.

    A 50-year-old man presented with right-sided facial weakness and consulted another hospital the next day. Bell’s palsy was diagnosed and treated with prednisolone. However, a week later, the facial palsy extended to the left side of the face. He was admitted to our hospital and was diagnosed with bilateral facial nerve paralysis. We investigated the cause of bilateral facial nerve palsy but were unable to reach a conclusive diagnosis. Sarcoidosis was believed to be the cause of bilateral facial palsy, given the disease’s progression and the presence of bilateral hilar lymphadenopathy. He was given steroids, and his palsy improved five months later. This study highlights that the involvement of systemic disease should be considered in patients with bilateral facial nerve palsy.

    DOI： 10.24805/jiaio.2.4_197

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  • 外鼻切除を行った鼻前庭癌の1例

    中野雅也, 山本圭佑, 大國毅, 高野賢一

    日本鼻科学会会誌(Web)   61 ( 3 )   2022

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  • Usefulness of Dual Knot Fixation Method for Correcting Nasal Septum Deviation Hemitransfixion Approach

    大國毅, 山本圭佑, 高野賢一

    日本鼻科学会会誌(Web)   61 ( 4 )   2022

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  • IgG4関連疾患に伴う鼻副鼻腔病変

    山本圭佑

    日本鼻科学会会誌(Web)   61 ( 1 )   2022

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  • 下咽頭梨状陥凹瘻に対して経口腔的瘻管焼灼術を施行した2例

    菅谷泰樹, 角木拓也, 山本圭佑, 大國毅, 黒瀬誠, 近藤敦, 高野賢一

    口腔・咽頭科   34 ( 3 )   2021

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  • 診断困難な鼻副鼻腔疾患に挑む

    司会:竹内 万彦, 吉田 尚弘, 演者:千代延 和貴, 常見 泰弘, 吉原 晋太郎, 山本 圭佑, 立山 香織

    日本鼻科学会会誌   60 ( 3 )   290 - 295   2021

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    Language：Japanese   Publisher：日本鼻科学会  

    DOI： 10.7248/jjrhi.60.290

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  • Classification of the Travel of the Anterior Superior Alveolar Nerve and Postoperative Symptoms in Endoscopic Modified Medial Maxillectomy

    Yamamoto Keisuke, Okuni Tsuyoshi, Takano Kenichi

    Nihon Bika Gakkai Kaishi (Japanese Journal of Rhinology)   60 ( 2 )   138 - 145   2021

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    Language：Japanese   Publisher：Japan Rhinologic Society  

    Endoscopic modified medial maxillectomy (EMMM) is a direct endoscopic approach to the maxillary sinus that preserves the nasal structure and allows for a large working space. EMMM is considered to have relatively few complications because it preserves the nasal structure, but sometimes patients experience pain and numbness in the lips, teeth, and cheeks. The cause of these symptoms is thought to be damage to the anterior superior alveolar nerve (ASAN), but the symptoms and the pathway of the ASAN have not been sufficiently investigated. In this study, we investigated the relationship between the presence or absence of symptoms after EMMM surgery and the travel classification of the ASAN. A total of 58 patients who underwent EMMM at the Department of Otorhinolaryngology, Sapporo Medical University between April 2013 and August 2019 were included in the study, excluding postoperative maxillary cysts and trauma cases in which the anterior wall of the maxillary sinus could not be evaluated. The total number of patients with nasolabial pain or numbness, dental pain or numbness, and buccal pain or numbness, which may be related to ASAN injury, was 7 (17.5%). Sinus CT revealed that 18 patients (45.0%) had no ASAN exposure in the maxillary sinus, and 22 patients (55.0%) had some ASAN exposure in the maxillary sinus. Statistical analysis showed a significant association between the presence of symptoms and ASAN travel classification. In papilloma cases with long-term persistent symptoms, the tumor was located directly above the “exposed” ASAN. Although ASAN injury in EMMM is one of the sequelae that has not received much attention, it is important to evaluate the risk of ASAN injury preoperatively based on the ASAN travel classification, and to obtain adequate explanation and consent from patients.

    Other Link:： https://search.jamas.or.jp/link/ui/2022007167

    DOI： 10.7248/jjrhi.60.138

    DOI： 10.7248/jjrhi.63.507_references_DOI_Wt94HUvgmIZOMNQrnfthydE7JZ4

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  • 当院で入院加療を受けたCOVID-19患者における嗅覚障害・味覚障害の疫学的検討

    山本圭佑, 小笠原徳子, 大國毅, 高野賢一

    日本耳鼻咽喉科学会会報   124 ( 4 )   2021

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  • 頭頸部扁平上皮癌の癌微小環境におけるAEBP1の解析

    萬顕, 山本圭佑, 小幡和史, 大國毅, 黒瀬誠, 近藤敦, 高澤啓, 小島隆, 鈴木拓, 高野賢一

    日本耳鼻咽喉科学会会報   124 ( 4 )   2021

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  • 顔面神経麻痺を来した頸部膿瘍症例

    酒本博史, 角木拓也, 山本圭佑, 大國毅, 黒瀬誠, 高野賢一

    耳鼻咽喉科臨床 補冊   ( 157 )   2021

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  • A Study on Fourteen Cases of Sinonasal Mucosal Malignant Melanoma

    Yamamoto Keisuke, Obata Kazufumi, Kondo Atsushi, Okuni Tsuyoshi, Kurose Makoto, Nakano Masaya, Sasaki Ayaka, Kakuki Takuya, Takano Kenichi

    Practica Oto-Rhino-Laryngologica   114 ( 9 )   659 - 667   2021

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    Language：Japanese   Publisher：The Society of Practical Otolaryngology  

    We reviewed the clinical data of 14 patients with mucosal malignant melanoma of the nasal/paranasal cavity from among 78 patients diagnosed as having malignant nasal/paranasal cavity tumors at our hospital between 2008 and 2018. There were 4 men and 10 women, aged 49–85 years (median: 69.0). The clinical TNM classification according to the 8th American Joint Committee on Cancer and the International Union Against Cancer Control (AJCC/UICC) was as follows: T3, 9 cases; T4a, 4 cases; T4b, 1 case; N0, 13 cases; N1, 1 case; stage III, 9 cases; stage IVA, 4 cases; stage IVc, 1 case. The overall 2-year, 3-year and 5-year survival rates (Kaplan-Meier method) were 50.0%, 42.9%, and 42.9%, respectively. The 2-year, 3-year and 5-year local control rates (Kaplan-Meier method) were 42.9%, 42.9%, 32.1%, respectively. Examination of the prognostic factors by univariate analysis showed that the prognosis was significantly poor in patients with cT4 or higher, with tumors in the sinuses, and with distant metastases. Examination of the surgical cases showed that distant metastases developed in 58.3% of cases even after complete resection by surgery. Control of distant metastasis is considered as being a problem that needs to be resolved in order to improve the treatment results of mucosal malignant melanoma of the nasal/paranasal cavity.

    Other Link:： https://ndlsearch.ndl.go.jp/books/R000000004-I031700364

    DOI： 10.5631/jibirin.114.659

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  • A comparison of modified Blair and esthetic incisions for benign parotid surgery: V-shaped incision for parotidectomy

    Yamamoto Keisuke, Kurose Makoto, Kakiuchi Akito, Kakuki Takuya, Takahashi Ayumi, Obata Kazufumi, Okuni Tsuyoshi, Kondo Atsushi, Takano Kenichi

    JOURNAL OF JAPAN SOCIETY FOR HEAD AND NECK SURGERY   31 ( 2 )   147 - 155   2021

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    Language：Japanese   Publisher：JAPAN SOCIETY FOR HEAD AND NECK SURGERY  

    Objective: The purpose of this study was to propose a V-shaped incision （VSI） and to compare cosmetic incisions, including modified facelift incision （mFLI）, retroauricular hairline incision （RAHI）, and VSI, with the conventional modified Blair incision （MBI） in terms of complications and esthetic outcomes for the treatment of benign parotid gland tumors.<br>Methods: We reviewed the clinical data of 37 patients who underwent partial parotidectomy as the primary treatment for benign parotid tumors between January 2017 and September 2019. The patients were divided into the MBI and mFLI/RAHI/VSI groups. Operation variables and cosmetic satisfaction of matched pairs were compared between the two groups.<br>Results: Twenty patients underwent conventional MBI, five patients mFLI, seven patients RAHI, and five patients VSI. The external ear canal cartilage, mastoids, the anterior edge of the sternocleidomastoid muscle, and the posterior belly of the digastric muscle could be visualized using VSI and therefore the tumor could be resected while identifying the main facial nerve trunk. The postoperative wound was localized around the ear lobe because there was no incision line from the posterior auricle to the mastoid process. We selected mFLI/RAHI/VSI over MBI for tumors that were significantly small and not anterior. The operation time and complications, including facial palsy, Frey’s syndrome, salivary fistulas, and wound problems, did not differ between the two groups. Reponses to the questions “Is the scar visible?” and “Do you want more esthetic surgery?” did not significantly differ between the two groups.<br>Conclusion: mFLI, RAHI, and VSI are safe and preferable approaches for parotidectomy, especially for tumors that are small and not anterior.

    Other Link:： https://search.jamas.or.jp/link/ui/2022066509

    DOI： 10.5106/jjshns.31.147

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  • IgG4関連疾患に伴う鼻副鼻腔病変

    山本圭佑

    日本鼻科学会会誌(Web)   60 ( 3 )   2021

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  • Hemitransfixionアプローチにて鼻中隔矯正術を行った前弯症例の臨床的検討

    大國毅, 宮田遼, 山本圭佑, 高野賢一

    日本鼻科学会会誌(Web)   60 ( 3 )   2021

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  • 鼻炎合併喘息患者におけるダニ舌下免疫療法の濾胞ヘルパー及び濾胞制御性T細胞を中心とした解析

    重原克則, 亀倉隆太, 亀倉隆太, 池上一平, 柳昌弘, 山本圭佑, 一宮慎吾

    アレルギー   70 ( 6/7 )   2021

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  • 細胞傷害性Tph細胞のオリゴクローナルな増殖がIgG4関連疾患の病態形成に関与する

    亀倉隆太, 亀倉隆太, 村山公介, 村山公介, 山本圭佑, 重原克則, 高野賢一, 一宮慎吾

    アレルギー   70 ( 6/7 )   2021

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  • プラークアッセイ法を用いたRSウイルス感染力価定量

    工由佳, 小笠原徳子, 小笠原徳子, 山本圭佑, 山本圭佑, 高野賢一, 横田伸一

    日本耳鼻咽喉科免疫アレルギー感染症学会総会・学術講演会プログラム・抄録集(CD-ROM)   1st   2021

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  • 末梢ヘルパーT細胞とIgG4関連疾患

    亀倉隆太, 亀倉隆太, 池上一平, 山本圭佑, 山本元久, 高橋裕樹, 高野賢一, 一宮慎吾

    日本シェーグレン症候群学会学術集会プログラム・抄録集   29th   2021

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  • 頭頸部癌における腫瘍浸潤免疫細胞タイプとICI効果の相関性

    黒瀬誠, 金関貴幸, 近藤敦, 大國毅, 小幡和史, 山本圭佑, 角木拓也, 酒本博史, 高野賢一

    日本耳鼻咽喉科学会会報   124 ( 4 )   2021

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  • RSウイルスが結合する核内タンパク質の機能解明

    小笠原徳子, 小笠原徳子, 山本圭佑, 山本圭佑, 工由佳, 高野賢一, 横田伸一

    日本耳鼻咽喉科免疫アレルギー感染症学会総会・学術講演会プログラム・抄録集(CD-ROM)   1st   2021

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  • Classification of the Travel of the Anterior Superior Alveolar Nerve and Postoperative Symptoms in Endoscopic Modified Medial Maxillectomy

    山本圭佑, 大國毅, 高野賢一

    日本鼻科学会会誌(Web)   60 ( 2 )   2021

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  • 上鼻甲介内側粘膜温存した蝶形骨洞開放症例の臨床的検討

    大國毅, 山本圭佑, 高野賢一

    日本鼻科学会会誌(Web)   59 ( Supplement )   2020

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  • 鼻中隔矯正術に対するNarrow band imaging(NBI)の応用

    山本圭佑, 黒瀬誠, 大國毅, 角木拓也, 中野雅也, 高野賢一

    日本耳鼻咽喉科学会会報   123 ( 4 )   2020

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  • Double Mucoperiosteal Flap Approach to Prevent Neo-ostial Restenosis after Draf IIb Surgery

    大國毅, 山本圭佑, 高野賢一

    日本鼻科学会会誌(Web)   59 ( 2 )   2020

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  • 下咽頭癌予後予測におけるCAR・NLRの有用性についての検討

    小幡和史, 山本圭佑, 黒瀬誠, 近藤敦, 高野賢一

    頭頸部癌   46 ( 2 )   2020

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  • 頭頸部がん組織におけるHLA提示ペプチドの網羅的解析

    黒瀬誠, 金関貴幸, 金関貴幸, 近藤敦, 大國毅, 小幡和史, 山本圭佑, 角木拓也, 中野雅也, 高野賢一

    日本耳鼻咽喉科学会会報   123 ( 4 )   2020

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  • 側頭骨に発生した修復性巨細胞肉芽腫の1例

    工由佳, 山本圭佑, 小幡和史, 大國毅, 黒瀬誠, 近藤敦, 高野賢一

    日本頭頸部外科学会総会ならびに学術講演会プログラム・予稿集   30th   2020

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  • 人工神経(神経再生誘導管)による副神経再建を施行した2例

    黒瀬誠, 近藤敦, 大國毅, 小幡和史, 山本圭祐, 角木拓也, 高野賢一

    日本頭頸部外科学会総会ならびに学術講演会プログラム・予稿集   30th   2020

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  • Examination of invasive fungal sinusitis for the past 5 years

    Yorozu Akira, Okuni Tsuyoshi, Yamamoto Keisuke, Takano Kenichi, Kurose Makoto, Himi Tetsuo

    JOURNAL OF JAPAN SOCIETY FOR HEAD AND NECK SURGERY   30 ( 1 )   35 - 41   2020

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    Language：Japanese   Publisher：JAPAN SOCIETY FOR HEAD AND NECK SURGERY  

    Invasive fungal sinusitis still has a poor prognosis, although removal of the lesion and infusion of antifungal drugs have been successfully applied to treat the disease in recent years. Here, we describe six cases of invasive fungal sinusitis that we experienced in the last 5 years. In case 1, MRI findings initially indicated a brain tumor spreading into the paranasal sinuses. Examination of a brain biopsy obtained by craniotomy resulted in the diagnosis of invasive fungal sinusitis, and skull base and reconstructive surgery were performed. Endoscopic sinus surgery was used to treat the other five cases. Two cases were diagnosed pathologically, resulting in a diagnosis of fungal invasion of the mucosa. In the other four cases, CT images indicated bone destruction and disease progression into the pterygopalatine fossa. Five patients survived but one patient died from underlying disease. This study demonstrates that this type of lesion can be removed by endoscopic sinus surgery and that appropriate infusion of Voriconazole is effective.

    Other Link:： https://search.jamas.or.jp/link/ui/2020327929

    DOI： 10.5106/jjshns.30.35

    DOI： 10.7248/jjrhi.63.486_references_DOI_M4GAXyxhf167vacA6uJ0K0yCsqS

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  • Double Mucoperiosteal Flap Approach to Prevent Neo-ostial Restenosis after Draf IIb Surgery

    Okuni Tsuyoshi, Yamamoto Keisuke, Takano Kenichi

    Nihon Bika Gakkai Kaishi (Japanese Journal of Rhinology)   59 ( 2 )   124 - 131   2020

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    Language：Japanese   Publisher：Japan Rhinologic Society  

    Draf type IIb and III are surgical approaches that are widely used to treat recalcitrant frontal sinusitis, frontal mucocele, and skull base tumors. The largest unilateral neo-ostium of the frontal sinus is created by Draf IIb surgery without affecting the intact side. This procedure involves resection of the frontal sinus floor between the lamina papyracea and the nasal septum anterior to the first olfactory fiber. Restenosis of the frontal sinus neo-ostium is a serious drawback associated with Draf IIb surgery. The double mucoperiosteal flap approach involves use of a lateral-nasoseptal flap and a septoturbinal flap harvested from the same nasal cavity. These double flaps can effectively cover the anterior and posterior walls of the frontal sinus neo-ostium. In this study, we performed Draf IIb surgery using the double flap technique in 6 patients, all of whom had patent neo-ostia at 6 months postoperatively. We report the feasibility of the double flap approach to prevent neo-ostial restenosis after Draf IIb surgery.

    DOI： 10.7248/jjrhi.59.124

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  • 私の新しい耳鼻咽喉科診療スタンダードー10～20年前とどう変わったかーIgG4 関連疾患の診断と治療の進歩．

    山本 圭佑

    MB ENT, 245   245 ( 245 )   82 - 89   2020

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  • 超音波検査による経過観察が診断に有用であった甲状腺原発悪性リンパ腫の1例

    宮谷, 政江, 菅原, 由佳, 渡邊, 紗規子, 岩村, 美樹, 山本, 圭佑, 今, 信一郎

    市立室蘭総合病院医誌 = Journal of Muroran City General Hospital   44 ( 1 )   24 - 29   2019.9

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    Language：Japanese   Publisher：市立室蘭総合病院  

    今回、慢性甲状腺炎の経過観察中に甲状腺腫大を認めず、可溶性インターロイキン2受容体（sIL-2R）も正常範囲であったが、超音波検査による経時的変化が甲状腺原発悪性リンパ腫の診断に有用であった1例を報告する。症例は69 歳女性。2016年6月、頚部腫大を自覚し当院耳鼻咽喉科を受診。血液検査から甲状腺機能は正常であったが、抗サイログロブリン抗体の上昇が認められた。超音波検査では両葉に嚢胞様低エコー腫瘤が多発していた。慢性甲状腺炎が疑われ半年毎の経過観察となっていた。2017年6月、3回目の定期超音波検査の際に、左葉の低エコーサイズ増大と、エコーレベルが極めて低く後方エコーの増強する偽嚢胞所見を認め、血流は豊富であった。気管前に多発する腫大リンパ節も認められた為、甲状腺原発悪性リンパ腫が疑われ精査が行われた。穿刺吸引細胞診でも悪性リンパ腫が疑われ、消化器内科を紹介受診した。各種検査が追加され、FDG-PETでも左葉のみ集積を認めた為、core needle biopsy を施行し、diffuse large B cell lymphoma（DLBCL）と診断された。経過観察中の超音波検査では、両葉低エコー病変の様々な変化と縮小増大を繰り返す経過を追う事が出来た。橋本病の経過観察中に低エコーの濃度変化を確認した時は悪性リンパ腫を念頭に置く必要があると考えられた。

    Other Link:： http://id.nii.ac.jp/1599/00016348/

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  • 札幌医科大学における過去10年間の下咽頭癌症例の検討

    山本 圭佑, 近藤 敦, 小幡 和史, 黒瀬 誠, 高野 賢一, 氷見 徹夫

    耳鼻咽喉科展望   62 ( Supplement1 )   s14 - s15   2019.6

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  • 特集 初診時に必要十分な 問診･検査オーダー虎の巻 《鼻領域》 後鼻漏

    山本 圭佑, 高野 賢一

    耳鼻咽喉科・頭頸部外科   91 ( 4 )   344 - 346   2019.4

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  • 当科で経験した大唾液腺腫瘍の術前診断に関する検討

    大國毅, 近藤敦, 黒瀬誠, 小幡和史, 山本圭佑, 高野賢一

    口腔・咽頭科   32 ( 3 )   2019

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  • A study of cervical lymph node metastasis from an unknown primary site diagnosed using core needle biopsy

    黒瀬誠, 近藤敦, 高野賢一, 大國毅, 小幡和史, 山本圭祐, 垣内晃人, 氷見徹夫

    頭頸部外科   29 ( 2 )   2019

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  • 頭頸部領域におけるコア針生検(core needle biopsy)の有用性

    黒瀬誠, 近藤敦, 大國毅, 小幡和史, 山本圭祐, 垣内晃人, 高野賢一, 氷見徹夫

    日本頭頸部外科学会総会ならびに学術講演会プログラム・予稿集   29th   2019

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  • Utility of V-Loc 180 closure device in oral pharyngeal reconstruction

    黒瀬誠, 近藤敦, 高野賢一, 大國毅, 小幡和史, 山本圭祐, 垣内晃人, 氷見徹夫

    口腔・咽頭科   32 ( 2 )   2019

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  • 気管原発軟骨肉腫の1例

    佐々木彩花, 黒瀬誠, 山本圭佑, 大國毅, 近藤敦, 高野賢一

    日本気管食道科学会総会ならびに学術講演会プログラム・予稿集   71st   2019

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  • 耳下腺良性腫瘍に対する皮膚切開線の検討

    山本圭佑, 黒瀬誠, 小幡和史, 大國毅, 近藤敦, 高野賢一

    口腔・咽頭科   32 ( 3 )   2019

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  • A Case of Endoscopic Endonasal Repair for Spontaneous Cerebrospinal Fluid Rhinorrhea of the Olfactory Cleft

    大國毅, 関伸彦, 山本圭佑, 高野賢一

    日本鼻科学会会誌(Web)   58 ( 2 )   2019

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  • Draf IIb後の前頭頭洞排泄路再狭窄予防の工夫-double mucoperiosteal flap法-

    大國毅, 山本圭祐, 宮田遼, 高野賢一

    日本鼻科学会会誌(Web)   58 ( 3 )   2019

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  • A Case of Endoscopic Endonasal Repair for Spontaneous Cerebrospinal Fluid Rhinorrhea of the Olfactory Cleft

    Okuni Tsuyoshi, Seki Nobuhiko, Yamamoto Keisuke, Takano Kenichi

    Nihon Bika Gakkai Kaishi (Japanese Journal of Rhinology)   58 ( 2 )   180 - 186   2019

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    Language：Japanese   Publisher：Japan Rhinologic Society  

    In spontaneous cerebrospinal fluid (CSF) rhinorrhea, nasal discharge containing CSF is partially caused by skull base defects unrelated to trauma, surgery, malformation, or tumor. Typically, this condition occurs in middle-aged overweight women and is associated with a high frequency of idiopathic intracranial hypertension. The most common symptom is persistent unilateral watery nasal discharge. Since, patients with spontaneous CSF rhinorrhea are at risk for developing purulent meningitis, it important for otolaryngologists to be familiar with this condition.

    Management of idiopathic CSF leaks often requires surgery, because skull base defects rarely resolve without intervention. Recently, endoscopic endonasal surgery with multilayer closure has become the gold standard for stopping spontaneous CSF leaks. For successful surgery, it is important to detect the sites of the fistula accurately before surgery. High-resolution CT (HRCT) should be performed initially for localizing skull base defects, and MR cisternography (MRC) is also a common diagnostic modality. CSF leaks can be visualized as a hypersignal intensity on coronal MRC images.

    Herein, we report the successful management of a case of spontaneous CSF rhinorrhea in the olfactory cleft that was treated with endonasal endoscopic management. We recommend using MRC for localizing small skull base fistulas followed endoscopic repair with the multilayer closure technique including local pedicle flaps for treatment.

    Other Link:： https://search.jamas.or.jp/link/ui/2020005277

    DOI： 10.7248/jjrhi.58.180

    DOI： 10.5631/jibirin.116.141_references_DOI_2gmutfZwjfOX7sqMZKeW0BYnxUu

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  • ナビゲーションシステム下にNBIを併用し内視鏡下経口腔的被膜間摘出術を行った副咽頭間隙神経鞘腫症例

    山本圭佑, 黒瀬誠, 宿村莉沙, 大國毅, 高野賢一

    日本頭頸部外科学会総会ならびに学術講演会プログラム・予稿集   29th   2019

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  • A Study on Head and Neck Malignant Lymphoma Diagnosed by Core Needle Biopsy

    Yamamoto Keisuke, Okuni Tsuyoshi, Kurose Makoto, Yorozu Akira, Owada Kizuku, Yajima Ryoto, Takahashi Ayumi, Obata Kazufumi, Kondo Atsushi, Takano Kenichi

    Practica Oto-Rhino-Laryngologica   112 ( 9 )   609 - 617   2019

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    Language：Japanese   Publisher：The Society of Practical Otolaryngology  

    Head and neck malignant lymphoma accounts for less than 10% of case of head and neck malignancies. Because patients with head and neck malignant lymphoma often present with neck swellings, they are often examined by otolaryngologists. Fine-needle aspiration cytology (FNAC) may yield useful clue to the ­diagnosis, although tissue biopsy is required for reliable diagnosis and classification of lymphoma, so that appropriate treatment can be administered. Although open biopsy of lymph nodes has been regarded as the standard method of tissue sampling, this method has drawbacks, including the risks associated with general anesthesia and surgical invasion, as well as the high cost and relatively long time to diagnosis. Core needle biopsy (CNB) provides a possible alternative to traditional FNAC and open biopsy. In this study, we assessed the usefulness of CNB in determining the histology of head and neck malignant lymphomas.

    Seven patients with suspected head and neck malignant lymphoma were examined by CNB between June 2017 and November 2018. Indications for CNB included a lesion diameter of ≥1.5 cm, lesion location at a distance from important blood vessels as judged by prior imaging examination, and the absence of bleeding tendency. US-guided CNB was performed using a Bard<sup>®</sup> Monopty<sup>®</sup> 14 G×90 mm, with a stroke length of 11 mm, or a Temno Evolution<sup>®</sup> 14 G×60 mm, with a stroke length of 10/20 mm.

    Of the seven lesions, four were in the neck, one was in the thyroid, and one was in the parotid gland. The mean lesion size was 4.3 cm (range, 2.5–6.8 cm). In all patients, the US-guided CNB was performed under local anesthesia. Histopathologically, four patients had diffuse large cell lymphoma, one had follicular lymphoma, one had MALT lymphoma, and one had ALK-negative anaplastic large cell lymphoma. The ­histopathological diagnosis could be made in all the patients by examination of the US-guided CNB, with none of the patients requiring further open biopsy. The shortest time from the first visit to biopsy was 0 day, with the CNB samples taken at the first outpatient consultation. None of the patients developed compli­cations such as hemorrhage, hematoma, infection, or facial nerve palsy.

    Lesions suspected as being malignant lymphoma not requiring surgical excision may be diagnosed by US-guided CNB, reducing the burden of invasion on the patients.

    Other Link:： https://ndlsearch.ndl.go.jp/books/R000000004-I029971380

    DOI： 10.5631/jibirin.112.609

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  • 当科におけるEndoscopic modified medial maxillectomy症例の検討

    山本圭佑, 大國毅, 村山公介, 宮田遼, 高野賢一

    日本鼻科学会会誌(Web)   58 ( 3 )   2019

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  • 原発不明頸部転移癌に対するコア針生検(core needle biopsy)

    黒瀬誠, 近藤敦, 小幡和史, 山本圭祐, 垣内晃人, 氷見徹夫

    頭頸部癌   44 ( 2 )   2018

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  • Experience of continuous intraoperative nerve monitoring in thyroid surgery

    黒瀬誠, 近藤敦, 高野賢一, 大國毅, 小幡和史, 山本圭祐, 垣内晃人, 萬顕, 氷見徹夫

    頭頸部外科   28 ( 2 )   2018

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  • 当科における頭頸部悪性リンパ腫に対するコア針生検(core needle biopsy)の経験

    山本圭佑, 大國毅, 大和田築, 高野賢一, 黒瀬誠, 氷見徹夫

    耳鼻咽喉科臨床 補冊   ( 153 )   2018

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  • 当科で経験した浸潤性副鼻腔真菌症の2例

    萬顕, 大國毅, 山本圭佑, 高野賢一, 黒瀬誠, 氷見徹夫

    日本頭頸部外科学会総会ならびに学術講演会プログラム・予稿集   28th   2018

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  • 甲状腺手術における術中持続神経モニタリング(CIONM)の使用経験

    黒瀬誠, 近藤敦, 高野賢一, 大國毅, 小幡和史, 山本圭祐, 萬顕, 氷見徹夫

    日本頭頸部外科学会総会ならびに学術講演会プログラム・予稿集   28th   2018

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  • 喉頭垂直部分切除症例におけるV-Locクロージャーデバイスの使用経験

    黒瀬誠, 近藤敦, 高野賢一, 大國毅, 小幡和史, 山本圭祐, 垣内晃人, 萬顕, 氷見徹夫

    頭頸部外科   28 ( 2 )   2018

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  • 外転神経麻痺単独で発症した急性蝶形骨洞炎の1例

    大和田築, 大國毅, 山本圭佑, 高野賢一, 黒瀬誠, 氷見徹夫

    日本頭頸部外科学会総会ならびに学術講演会プログラム・予稿集   28th   2018

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  • 当院における鼻副鼻腔悪性リンパ腫の検討

    山本圭佑, 宮田遼, 大國毅, 高野賢一

    日本鼻科学会会誌(Web)   57 ( 3 )   2018

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  • 内視鏡下経鼻手術にて閉鎖しえた特発性髄液鼻漏の一例

    大國毅, 白崎英明, 高野賢一, 関伸彦, 山本圭祐, 氷見徹男, 氷見徹男

    日本鼻科学会会誌(Web)   57 ( 3 )   2018

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  • 頭蓋・眼窩に進展した鼻副鼻腔内反性乳頭腫の一例

    大國毅, 黒瀬誠, 高野賢一, 山本圭祐, 萬顕, 氷見徹夫

    日本頭頸部外科学会総会ならびに学術講演会プログラム・予稿集   28th   2018

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  • 口蓋扁桃に発症した胚中心進展性異形成の1例

    長屋朋典, 坪松ちえ子, 小幡和史, 山本圭佑, 佐藤里奈, 近藤敦, 氷見徹夫

    耳鼻咽喉科臨床 補冊   ( 150 )   2017

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  • 下咽頭癌における重複癌症例の検討

    近藤敦, 山本圭祐, 小幡和史, 黒瀬誠, 氷見徹夫

    頭頸部癌   43 ( 2 )   2017

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  • 当科における過去10年間の浸潤性副鼻腔真菌症

    萬顕, 山本圭佑, 伊藤史恵, 高野賢一, 氷見徹夫

    日本耳鼻咽喉科感染症・エアロゾル学会会誌   5 ( 3 )   2017

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  • クラリスロマイシンは気道上皮細胞でRSウイルスによって誘導されるインターフェロンの産生をIRF-3を介して調整する

    山本圭佑, 小笠原徳子, 高野賢一, 氷見徹夫

    日本耳鼻咽喉科免疫アレルギー学会プログラム・抄録集   35th   2017

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  • 当科における下咽頭癌,重複癌症例の検討

    山本圭佑, 近藤敦, 佐藤里奈, 小幡和史, 長屋朋典, 黒瀬誠, 坪松ちえ子, 氷見徹夫

    耳鼻咽喉科臨床 補冊   ( 150 )   2017

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  • クラリスロマイシンは気道上皮でRSVによって誘導されるインターフェロンをIRF-3を介して調整する

    山本圭佑, 小笠原徳子, 高野賢一, 宮田遼, 角木拓也, 亀倉隆太, 氷見徹夫

    日本耳鼻咽喉科学会会報   120 ( 4 )   2017

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  • 当科における頭頸部癌遊離再建症例の検討

    今野信宏, 垣内晃人, 山本圭佑

    頭頸部癌   42 ( 2 )   2016

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  • 函館地区におけるアレルギー性鼻炎の実態調査 MAST33を用いたアレルゲンの検討

    今野信宏, 垣内晃人, 山本圭佑, 計良宗, 坪田大

    函館医学誌   40 ( 1 )   2016

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  • 当科における鼻副鼻腔乳頭腫症例の検討

    大國毅, 白崎英明, 高野賢一, 野村一顕, 山本圭佑, 氷見徹夫

    日本鼻科学会会誌(Web)   55 ( 3 )   2016

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  • ウイルス性呼吸器感染症 : 冬期のRSウイルス流行に備えて—特集 これからを見据えた呼吸器感染症治療 ; 最新動向から見直す呼吸器感染症マネジメント

    小笠原 徳子, 横田 伸一, 山本 圭佑

    感染と抗菌薬 = Infection and antimicrobials   18 ( 3 )   242 - 246   2015.9

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    Language：Japanese   Publisher：東京 : ヴァンメディカル  

    Other Link:： https://ndlsearch.ndl.go.jp/books/R000000004-I026750234

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  • A case of foreign body(toothbrush)located in the retropharyngeal space

    山本圭佑, 山本圭佑, 大國毅, 小笠原徳子, 今野信宏, 坪田大, 氷見徹夫

    耳鼻咽喉科・頭頚部外科   87 ( 2 )   183 - 188   2015.2

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  • RSウィルス感染時のヒト気道上皮細胞における抗菌薬の抗炎症効果とその作用点の検討

    山本圭佑, 山本圭佑, 小笠原徳子, 小笠原徳子, 高野賢一, 氷見徹夫

    日本耳鼻咽喉科感染症・エアロゾル学会会誌   3 ( 3 )   2015

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  • P-212 函館地区におけるアレルギー性鼻炎の実態調査 : MAST33を用いたアレルゲンの検討(アレルギー性鼻炎 疫学,口演30,第26回日本アレルギー学会春季臨床大会)

    今野 信宏, 山本 圭佑, 坪田 大

    アレルギー   63 ( 3-4 )   595   2014

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    Language：Japanese   Publisher：一般社団法人 日本アレルギー学会  

    DOI： 10.15036/arerugi.63.595_4

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  • ヒト気道上皮細胞におけるRSウイルス感染によるサイトカイン産生誘導と抗生剤による阻害効果の検討

    山本圭佑, 高野賢一, 小笠原徳子, 黒瀬誠, 野村一顕, 宮田遼, 角木拓也, 氷見徹夫

    日本鼻科学会会誌(Web)   53 ( 3 )   2014

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  • 頭頸部癌治療中に発症した敗血症性DICに対して,リコンビナント・トロンボモジュリン製剤が著効した1例

    今野信宏, 山本圭佑, 垣内晃人, 坪田大

    頭頸部癌   40 ( 2 )   2014

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  • ヒト気道上皮細胞に対するRSウイルス感染によるサイトカイン産生能と抗生剤投与による阻害効果の検討

    高野賢一, 山本圭佑, 山本圭佑, 小笠原徳子, 小笠原徳子, 小泉純一, 氷見徹夫

    日本耳鼻咽喉科感染症・エアロゾル学会会誌   2 ( 3 )   2014

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  • 耳鼻咽喉科とウイルス 上気道粘膜とウイルス感染

    氷見徹夫, 高野賢一, 大國毅, 小笠原徳子, 山本圭佑, 高橋希

    JOHNS   30 ( 11 )   2014

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  • 下咽頭に発生したリンパ上皮癌の1例

    今野信宏, 山本圭佑, 坪田大

    日本頭頸部外科学会総会ならびに学術講演会プログラム・予稿集   24th   2014

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  • 外耳道に限局して発生した血管性病変の3症例

    山本圭佑, 山本圭佑, 今野信宏, 坪田大, 氷見徹夫

    日本耳鼻咽喉科学会会報   117 ( 4 )   2014

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  • 降下性壊死性縦隔炎に対し胸腔鏡下縦隔ドレナージ術を施行した1例

    小泉純一, 高野賢一, 小笠原徳子, 山本圭佑, 氷見徹夫

    日本耳鼻咽喉科感染症・エアロゾル学会会誌   2 ( 3 )   2014

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  • A case of thyroglossal duct cyst requiring a tracheostomy

    山本圭佑, 関伸彦, 白崎英明, 近藤敦, 長屋朋典, 宮田遼, 氷見徹夫

    耳鼻咽喉科・頭頚部外科   85 ( 8 )   633 - 637   2013.7

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  • well-differentiated tumor of uncertain malignant potential(WDT-UMP)の1例

    山本圭佑, 今野信宏, 坪田大

    耳鼻咽喉科臨床 補冊   ( 135 )   2013

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  • 歯ブラシによる口腔,咽頭腔外異物の2例

    山本圭佑, 坪田大, 高橋佑美, 今野信宏, 柿崎隆一郎, 三上昭廣, 太田知明

    道南医学会大会並びに総会プログラム・抄録集   66th   2013

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  • 口腔底腺様嚢胞癌多発肺転移症例に対するCDDP,TXT,S-1併用療法の使用経験

    今野信宏, 山本圭佑, 坪田大

    日本頭頸部外科学会総会ならびに学術講演会プログラム・予稿集   23rd   2013

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  • カテーテル感染に続発した血栓性静脈炎による発熱と鑑別を要した薬剤熱の1例

    今野信宏, 山本圭佑, 坪田大

    頭頸部癌   39 ( 2 )   2013

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  • 気管切開を要した甲状舌管嚢胞の1例

    山本圭佑, 関伸彦, 白崎英明, 近藤敦, 長屋朋典, 宮田遼, 氷見徹夫

    耳鼻咽喉科臨床 補冊   ( 133 )   2012

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Research Projects

  • T 細胞疲弊を標的としたアレルギー性鼻炎の新規治療戦略

    Grant number：22K09670  2022.4 - 2026.3

    日本学術振興会  科学研究費助成事業  基盤研究(C)

    山本 圭佑, 一宮 慎吾, 高野 賢一, 亀倉 隆太

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    Grant amount：\4160000 （ Direct Cost: \3200000 、 Indirect Cost：\960000 ）

    アレルゲン免疫療法(allergen immunotherapy, AIT) は根治が期待できる唯一のアレルギー性鼻炎の治療法である。しかし、無効例が存在することや治療効果を予測するバイオマーカーが確立していない問題点がある。AIT の更なる普及のためには、奏効率の向上とバイオマーカーの発見が喫緊の課題である。われわれはこれまでの舌下免疫療法施行例の検討で、特定の CD4 T 細胞サブセットの免疫疲弊(exhaustion) が AIT の新たな免疫学的メカニズムとして重要な役割を担っていると仮説を立てた。T細胞疲弊とはT 細胞の機能低下状態であり、慢性感染症やがんにおいて T 細胞受容体を介する抗原特異的シグナルの持続および不安定な共刺激・共抑制シグナル（CD28 や PD-1 など）が引き起こす。自己免疫疾患やアレルギー疾患に対して、 T 細胞疲弊が治療標的となる可能性がある。
    免疫療法に伴い増加する疲弊 CD 4 T 細胞の機能を明らかにすることで、AIT の免疫学的メカニズムの全容解明と治療効果を予測するバイオマーカーの発見に繋げたい。本研究では、T 細胞疲弊の観点からAIT の免疫学的メカニズム、特殊な機能をもったアレルギー関連細胞としてのTfh2 細胞によるアレルギー性鼻炎の病態を明らかにし、新規治療法の開発や免疫疲弊を人為的に制御する新たなモダリティの開発に繋げることを目的としている。すなわち、AIT によりCD4 陽性T 細胞サブセット、特にTfh2 細胞に疲弊現象が起きているのか？ 治療によりどのようなTfh2 細胞の機能変容が起きて治療効果に結びついているのか？ T細胞疲弊の誘導がアレルゲン免疫療法の奏効率の上昇に繋がるのか？を明らかにする。

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  • Novel Therapeutic Strategies for Birch Pollinosis by Targeting Functional Lymphocytes

    Grant number：18K16898  2018.4 - 2022.3

    Japan Society for the Promotion of Science  Grants-in-Aid for Scientific Research  Grant-in-Aid for Early-Career Scientists

    Yamamoto Keisuke

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    Grant amount：\4160000 （ Direct Cost: \3200000 、 Indirect Cost：\960000 ）

    It was found that Tfh2 cells are increased in patients with birch pollinosis compared to healthy controls, and that allergen immunotherapy (AIT) corrects the Tfh2 shift in the peripheral blood of patients and increases regulatory lymphocytes, the brake of the immune response. Observations of long-term AIT patients revealed that correction of Tfh2 shift in patients' peripheral blood is clearly observed at 12 months, that continuous allergen immunotherapy increases regulatory T cells, the brake of immune response, and that regulatory B cells may regulate antigen-specific IgE production. The results of the study revealed that the regulatory B cells may regulate the production of antigen-specific IgE.

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  • The mechanisms of salivary gland fibrosis in IgG4-related disease

    Grant number：18K09324  2018.4 - 2021.3

    Japan Society for the Promotion of Science  Grants-in-Aid for Scientific Research  Grant-in-Aid for Scientific Research (C)

    Takano Kenichi

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    Grant amount：\4290000 （ Direct Cost: \3300000 、 Indirect Cost：\990000 ）

    The aim of this study was to investigate the mechanisms driving fibrosis in the submandibular glands (SMG) of patients with IgG4-related disease (IgG4-RD). Our results suggest fibrosis in the SMG of affected patients is closely linked to the proliferation of fibroblasts following induction of IL-6 and WISP1 by inflammatory cytokines. The Th2 cytokines TSLP and IL-33 are also upregulated in affected SMG, and thus may cause chronic inflammation and IgG4 accumulation.

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  • Usefulness of disease-specific microRNA for respiratory syncytial virus induced lower respiratory tract inflammation

    Grant number：16K20266  2016.4 - 2018.3

    Japan Society for the Promotion of Science  Grants-in-Aid for Scientific Research  Grant-in-Aid for Young Scientists (B)

    Yamamoto Keisuke, HIMI Tetsuo, YOKOTA Shin-ichi, Takano Kenichi, KUROSE Makoto, KAMEKURA Ryuta, OHKUNI Tsuyoshi, OGASAWARA Noriko, YAMAMOTO Soh

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    Grant amount：\3900000 （ Direct Cost: \3000000 、 Indirect Cost：\900000 ）

    (1)Clarithromycin (CAM) as a treatment of RSV infection and (2)disease-specific microRNA as an index of disease evaluation were examined.CAM treatment led to a significant reduction in RSV-mediated IL-8, CCL5, IFN-βand -λ production.Furthermore,IFN-β promoter activity (activated by poly I:C and RSV infection) was significantly reduced after treatment with CAM.CAM also inhibited IRF-3 dimerization and subsequent translocation to the nucleus.
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    RSV infection-specific secreted miRNAs were identified. Housekeeping gene of nasal secreted miRNA was identified.

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