YOSHII Shinji

写真a

Affiliation

School of Medicine, Department of Gastroenterology

Job title

Lecturer
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Research Experience 【 display / non-display 】

  • 2019.07
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    Sapporo Medical University   School of Medicine   助教

    助教

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Professional Memberships 【 display / non-display 】

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    日本消化管学会

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    THE JAPANESE SOCIETY OF INTERNAL MEDICINE

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    The Japanese Society of Gastroenterology

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    JAPAN GASTROENTEROLOGICAL ENDOSCOPY SOCIETY

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Research Areas 【 display / non-display 】

  • Life sciences   Gastroenterology  

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Affiliation 【 display / non-display 】

  • -   消化器内科学講座  

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Research Interests 【 display / non-display 】

  • helicobacter pylori

  • colorectal neoplasm

  • endoscopy

  • colorectal T1 cancer

  • submucosal invasive cancer

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Papers 【 display / non-display 】

  • Validity of endoscopic features for the diagnosis of Helicobacter pylori infection status based on the Kyoto classification of gastritis.

    Yoshii S, Mabe K, Watano K, Ohno M, Matsumoto M, Ono S, Kudo T, Nojima M, Kato M, Sakamoto N

    Digestive endoscopy : official journal of the Japan Gastroenterological Endoscopy Society   32 ( 1 ) 74 - 83  2019.07  [Refereed]  [International journal]

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    OBJECTIVES: Evaluation of Helicobacter pylori infection status (non-infection, past infection, current infection) has become important. This study aimed to determine the usefulness of the Kyoto classification of gastritis for diagnosing H. pylori infection status by endoscopy. METHODS: In this prospective study, 498 subjects were recruited. Seven well-experienced endoscopists blinded to the history of eradication therapy performed the examinations. Endoscopic findings were assessed according to the Kyoto classification of gastritis: diffuse redness, regular arrangement of collecting venules (RAC), fundic gland polyp (FGP), atrophy, xanthoma, hyperplastic polyp, map-like redness, intestinal metaplasia, nodularity, mucosal swelling, white and flat elevated lesion, sticky mucus, depressive erosion, raised erosion, red streak, and enlarged folds. We established prediction models according to a machine learning procedure and compared them with general assessment by endoscopists using the Kyoto classification of gastritis. RESULTS: Significantly higher diagnostic odds were obtained for RAC (32.2), FGP (7.7), and red streak (4.7) in subjects with non-infection, map-like redness (12.9) in subjects with past infection, and diffuse redness (26.8), mucosal swelling (13.3), sticky mucus (10.2) and enlarged fold (8.6) in subjects with current infection. The overall diagnostic accuracy rate was 82.9% with the Kyoto classification of gastritis. The diagnostic accuracy of the prediction model was 88.6% for the model without H. pylori eradication history and 93.4% for the model with eradication history. CONCLUSIONS: The Kyoto classification of gastritis is useful for diagnosing H. pylori infection status based on endoscopic findings. Our prediction model is helpful for novice endoscopists. (UMIN000016674).

    DOI PubMed

  • Continuous Anticoagulation and Cold Snare Polypectomy Versus Heparin Bridging and Hot Snare Polypectomy in Patients on Anticoagulants With Subcentimeter Polyps: A Randomized Controlled Trial.

    Takeuchi Y, Mabe K, Shimodate Y, Yoshii S, Yamada S, Iwatate M, Kawamura T, Hotta K, Nagaike K, Ikezawa N, Yamasaki T, Komeda Y, Asai S, Abe Y, Akamatsu T, Sakakibara Y, Ikehara H, Kinjo Y, Ohta T, Kitamura Y, Shono T, Inoue T, Ohda Y, Kobayashi N, Tanuma T, Sato R, Sakamoto T, Harada N, Chino A, Ishikawa H, Nojima M, Uraoka T, Madowazu, Study Group

    Annals of internal medicine   171 ( 4 ) 229 - 237  2019.07  [Refereed]  [International journal]

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    BACKGROUND: Management of anticoagulants for patients undergoing polypectomy is still controversial. Cold snare polypectomy (CSP) is reported to cause less bleeding than hot snare polypectomy (HSP). OBJECTIVE: To compare outcomes between continuous administration of anticoagulants (CA) with CSP (CA+CSP) and periprocedural heparin bridging (HB) with HSP (HB+HSP) for subcentimeter colorectal polyps. DESIGN: Multicenter, parallel, noninferiority randomized controlled trial. (University Hospital Medical Information Network Clinical Trials Registry: UMIN000019355). SETTING: 30 Japanese institutions. PATIENTS: Patients receiving anticoagulant therapy (warfarin or direct oral anticoagulants) who had at least 1 nonpedunculated subcentimeter colorectal polyp. INTERVENTION: Patients were randomly assigned to undergo HB+HSP or CA+CSP and followed up 28 days after polypectomy. MEASUREMENTS: The primary end point was incidence of polypectomy-related major bleeding (based on the incidence of poorly controlled intraprocedural bleeding or postpolypectomy bleeding requiring endoscopic hemostasis). The prespecified inferiority margin was -5% (CA+CSP vs. HB+HSP). RESULTS: A total of 184 patients were enrolled: 90 in the HB+HSP group, 92 in the CA+CSP group, and 2 who declined to participate after enrollment. The incidence of polypectomy-related major bleeding in the HB+HSP and CA+CSP groups was 12.0% (95% CI, 5.0% to 19.1%) and 4.7% (CI, 0.2% to 9.2%), respectively. The intergroup difference for the primary end point was +7.3% (CI, -1.0% to 15.7%), with a 0.4% lower limit of 2-sided 90% CI, demonstrating the noninferiority of CA+CSP. The mean procedure time for each polyp and the hospitalization period were longer in the HB+HSP than in the CA+CSP group. LIMITATION: An open-label trial assessing 2 factors (anticoagulation approach and polypectomy procedure type) simultaneously. CONCLUSION: Patients having CA+CSP for subcentimeter colorectal polyps who were receiving oral anticoagulants did not have an increased incidence of polypectomy-related major bleeding, and procedure time and hospitalization were shorter than in those having HB+HSP. PRIMARY FUNDING SOURCE: Japanese Gastroenterological Association.

    DOI PubMed

  • Concise Commentary: Caution, Not Cauterization-Management of Post-ESD Colorectal Hemorrhage.

    Yoshii S

    Digestive diseases and sciences   64 ( 3 ) 888 - 889  2019.03  [Refereed]

    DOI PubMed

  • Cold snare polypectomy technique is a procedure with a low bleeding risk

    Shinji Yoshii, Mio Matsumoto

    Digestive Endoscopy ( Blackwell Publishing )  30   51 - 52  2018.04  [Refereed]

    DOI PubMed

  • Endoscopic management of colorectal tumors less than 10 mm in size: Current status and future perspectives in Japan from a questionnaire survey.

    Toshio Uraoka, Shiro Oka, Shin Ichihara, Mineo Iwatate, Naoto Tamai, Takuji Kawamura, Yoji Takeuchi, Yuichi Mori, Shinji Yoshii, Shinichi Hashimoto, Shiaw Hooi Ho, Han-Mo Chiu

    Digestive endoscopy : official journal of the Japan Gastroenterological Endoscopy Society   30 Suppl 1   36 - 40  2018.04  [Refereed]  [International journal]

    DOI PubMed

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Books and Other Publications 【 display / non-display 】

  • これだけは読んでおきたい！ 消化器内視鏡医のための重要論文200篇〈消化管腫瘍編〉

    吉井 新二( Part： Contributor)

    株式会社シービーアール  2018

  • 下部消化管内視鏡スクリーニング検査マニュアル

    吉井 新二( Part： Contributor)

    医学図書出版株式会社  2018

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Misc 【 display / non-display 】

  • 10mm以下の大腸ポリープに対する抗凝固薬継続コールドスネアポリペクトミーの安全性の検討 多施設無作為化比較試験

    松本 美桜, 吉井 新二, 田沼 徳真, 佐藤 龍, 間部 克裕, 野島 正寛, 竹内 洋司

    日本消化器病学会北海道支部例会プログラム・抄録集 ( 日本消化器病学会-北海道支部 )  125回   32 - 32  2019.09

  • 【早期大腸癌内視鏡治療後の転移再発と予後】先行する内視鏡治療は追加手術後の予後に影響するか? 予後に影響させないための注意点

    吉井 新二, 奥田 博介, 久須美 貴哉, 塚越 洋元

    Intestine ( (株)日本メディカルセンター )  23 ( 3 ) 253 - 256  2019.05

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    ＜文献概要＞転移の可能性のある大腸T1癌に内視鏡治療を行うことが追加手術後の予後に影響を与えないか危惧される.内視鏡治療の熱焼灼によって遺残腫瘍の増殖能が上がるという報告や,切除後検体からは評価できない非連続性脈管侵襲の報告等,慎重な意見がある一方,長期成績,周術期の合併症,死亡例の比較において先行する内視鏡治療は予後に影響しないと考えられている.しかし,SM 浸潤度以外のリスク因子はすべて腫瘍先進部の組織所見であることから,確実に一括完全摘除することがきわめて重要である.また,精度の高い内視鏡診断を行い,適切な切除標本の取り扱いができるように病理側と密接に連携することが重要である.

  • IBDの超音波によるモニタリング 潰瘍性大腸炎に対する超音波検査の有用性 多施設共同前向き研究

    桂田 武彦, 木下 賢治, 西田 睦, 表原 里実, 大西 礼造, 前本 篤男, 江藤 和範, 吉井 新二, 山本 純司, 坂本 直哉

    超音波医学 ( (公社)日本超音波医学会 )  46 ( Suppl. ) S309 - S309  2019.04

  • groove膵癌の2例

    古川 龍太郎, 久保 茉理奈, 太宰 昌佳, 小野寺 学, 横山 朗子, 工藤 真弓, 吉井 新二

    日本消化器病学会北海道支部例会プログラム・抄録集 ( 日本消化器病学会-北海道支部 )  124回   73 - 73  2019.03

  • 総胆管結石に対するESWLの治療成績の検討

    小野寺 学, 久保 茉理奈, 古川 龍太郎, 太宰 昌佳, 横山 朗子, 工藤 真弓, 吉井 新二

    日本消化器病学会雑誌 ( (一財)日本消化器病学会 )  116 ( 臨増総会 ) A321 - A321  2019.03

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Awards 【 display / non-display 】

  • Travel grant in IDEN2018

    2018.06   Efficacy of a multifunctional snare (SOUTEN) for precutting endoscopic mucosal resection and endoscopic submucosal dissection.

    Winner： 吉井 新二

  • 第81回大腸癌研究会 優秀発表賞

    2013.07   大腸癌研究会   T1大腸癌に対する内視鏡治療の適応拡大

    Winner： 吉井 新二

  • 平成24年度日本消化器内視鏡学会 学会賞

    2012.10   日本消化器内視鏡学会   大腸SM癌内視鏡的摘除後経過観察例の予後

    Winner： 吉井 新二

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Committee Memberships 【 display / non-display 】

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      学術評議員

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